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chr2:22,911,727-26,262,948

Best TWAS P=5.51e-48 · Best GWAS P=2.43e-46 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
19	GTEx	Cells EBV-transformed lymphocytes	PFN4	0.18	0.13	lasso	12	0.12	8.9e-05	12.73	14.6	5.5e-48	0.78	0.07	0.80	TRUE
42	GTEx	Nerve Tibial	PFN4	0.25	0.16	lasso	5	0.20	3.8e-14	12.73	13.0	1.7e-38	0.61	1.00	0.00	TRUE
66	The Cancer Genome Atlas	Glioblastoma Multiforme	PFN4	0.37	0.13	blup	43	0.16	1.4e-05	12.95	11.6	2.4e-31	0.52	0.00	0.94	TRUE
22	GTEx	Colon Sigmoid	DNMT3A	0.19	-0.01	lasso	8	0.00	4.5e-01	-5.37	-7.9	3.0e-15	-0.03	0.07	0.14	TRUE
52	ROSMAP	Brain Pre-frontal Cortex	TP53I3	0.11	0.11	bslmm	315	0.11	1.4e-13	-5.44	7.9	3.6e-15	0.38	1.00	0.00	TRUE
31	GTEx	Esophagus Muscularis	UBXN2A	0.08	0.07	lasso	6	0.06	2.4e-04	-7.24	-7.2	7.7e-13	-0.21	0.64	0.02	TRUE
23	GTEx	Colon Transverse	SF3B14	0.09	0.05	lasso	9	0.02	4.9e-02	5.12	6.4	1.6e-10	0.52	0.52	0.07	TRUE
36	GTEx	Heart Left Ventricle	PFN4	0.23	0.28	lasso	6	0.28	4.1e-15	12.77	13.9	5.2e-44	0.76	0.98	0.02	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	PFN4	0.13	0.01	lasso	12	0.01	9.7e-02	14.10	13.7	1.5e-42	0.73	0.06	0.47	FALSE
50	METSIM	Adipose	PFN4	0.04	0.01	blup	306	0.03	1.9e-05	12.95	13.5	2.5e-41	0.72	0.20	0.68	FALSE
30	GTEx	Esophagus Mucosa	PFN4	0.16	0.15	lasso	4	0.15	3.6e-10	12.73	13.4	6.2e-41	0.71	0.53	0.47	FALSE
40	GTEx	Muscle Skeletal	PFN4	0.12	0.09	lasso	4	0.09	5.6e-09	12.73	13.2	8.7e-40	0.66	0.72	0.28	FALSE
2	CommonMind	Brain Pre-frontal Cortex	UBXN2A	0.22	0.18	enet	28	0.24	3.0e-28	11.62	-13.2	1.1e-39	-0.93	0.01	0.99	FALSE
75	The Cancer Genome Atlas	Brain Lower Grade Glioma	UBXN2A	0.04	0.04	lasso	1	0.03	1.4e-04	13.13	-13.1	2.2e-39	-0.96	0.02	0.94	FALSE
7	GTEx	Adrenal Gland	PFN4	0.20	0.15	lasso	2	0.18	3.9e-07	12.95	13.1	3.4e-39	0.62	0.10	0.55	FALSE
79	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PFN4	0.10	0.07	enet	5	0.08	5.5e-09	12.95	13.1	5.0e-39	0.62	0.00	1.00	FALSE
84	The Cancer Genome Atlas	Prostate Adenocarcinoma	PFN4	0.12	0.08	lasso	6	0.07	6.3e-08	12.73	13.1	5.3e-39	0.65	0.00	1.00	FALSE
67	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PFN4	0.13	0.07	lasso	4	0.06	4.4e-07	12.73	13.0	1.3e-38	0.65	0.00	1.00	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	PFN4	0.05	0.03	lasso	1	0.03	1.7e-04	12.95	13.0	2.3e-38	0.66	0.31	0.25	FALSE
77	The Cancer Genome Atlas	Lung Adenocarcinoma	PFN4	0.15	0.09	lasso	3	0.09	7.3e-11	12.95	13.0	2.3e-38	0.66	0.00	1.00	FALSE
5	GTEx	Adipose Visceral Omentum	PFN4	0.08	0.02	enet	14	0.04	3.1e-03	12.73	12.9	3.0e-38	0.66	0.04	0.61	FALSE
47	GTEx	Thyroid	PFN4	0.17	0.05	lasso	8	0.14	6.1e-11	12.77	12.9	6.0e-38	0.55	0.72	0.24	FALSE
58	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PFN4	0.11	0.00	enet	8	0.03	9.2e-04	12.73	12.9	6.9e-38	0.61	0.01	0.98	FALSE
24	GTEx	Colon Transverse	PFN4	0.14	0.07	lasso	2	0.04	3.3e-03	12.77	12.8	1.6e-37	0.66	0.11	0.11	FALSE
86	The Cancer Genome Atlas	Rectum Adenocarcinoma	PFN4	0.38	0.11	lasso	5	0.05	2.8e-02	12.73	12.8	1.6e-37	0.66	0.01	0.71	FALSE
70	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PFN4	0.10	0.07	lasso	2	0.06	1.1e-07	12.73	12.8	1.7e-37	0.66	0.00	1.00	FALSE
82	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PFN4	0.20	0.18	lasso	1	0.16	4.3e-07	12.77	12.8	2.3e-37	0.66	0.00	1.00	FALSE
61	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PFN4	0.19	0.16	lasso	2	0.15	5.5e-08	12.73	12.7	3.8e-37	0.66	0.00	1.00	FALSE
39	GTEx	Lung	PFN4	0.14	0.12	enet	8	0.15	7.6e-12	12.73	12.7	5.1e-37	0.60	0.98	0.01	FALSE
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	PFN4	0.09	0.07	blup	43	0.08	5.3e-09	12.95	12.4	3.1e-35	0.58	0.00	1.00	FALSE
44	GTEx	Pituitary	PFN4	0.34	0.03	lasso	14	0.02	1.1e-01	12.95	12.3	6.2e-35	0.53	0.04	0.18	FALSE
14	GTEx	Brain Putamen basal ganglia	PFN4	0.32	0.17	lasso	5	0.12	1.1e-03	12.95	12.3	9.4e-35	0.63	0.06	0.27	FALSE
34	GTEx	Heart Atrial Appendage	PFN4	0.22	0.06	lasso	7	0.10	2.8e-05	-5.44	12.1	1.8e-33	0.62	0.20	0.71	FALSE
15	GTEx	Breast Mammary Tissue	PFN4	0.08	0.04	enet	16	0.05	1.0e-03	12.73	12.0	4.1e-33	0.59	0.04	0.62	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	UBXN2A	0.03	0.01	lasso	4	0.02	2.2e-03	13.17	-11.8	3.9e-32	-0.80	0.03	0.92	FALSE
33	GTEx	Heart Atrial Appendage	UBXN2A	0.08	0.02	lasso	3	0.02	5.2e-02	13.17	11.8	4.1e-32	0.93	0.03	0.91	FALSE
80	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PFN4	0.08	0.03	blup	43	0.03	6.0e-03	12.95	11.7	7.6e-32	0.50	0.00	0.61	FALSE
72	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PFN4	0.14	0.02	blup	43	0.03	5.4e-03	12.95	11.7	1.5e-31	0.54	0.00	0.96	FALSE
88	The Cancer Genome Atlas	Thyroid Carcinoma	PFN4	0.21	0.10	blup	43	0.15	8.4e-15	12.73	11.7	2.1e-31	0.51	0.00	1.00	FALSE
90	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	PFN4	0.27	0.02	blup	43	0.08	3.1e-03	12.73	11.5	1.2e-30	0.50	0.00	0.84	FALSE
21	GTEx	Cells Transformed fibroblasts	PFN4	0.15	0.05	enet	10	0.14	2.3e-10	12.73	11.5	1.8e-30	0.50	0.94	0.03	FALSE
38	GTEx	Lung	KLHL29	0.08	0.00	lasso	6	0.00	3.4e-01	12.73	11.2	3.0e-29	0.58	0.04	0.85	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	FKBP1B	0.04	0.02	enet	5	0.04	9.0e-05	-5.99	-11.2	6.7e-29	-0.44	0.09	0.34	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	PFN4	0.15	0.08	blup	43	0.11	1.9e-22	12.77	11.1	1.2e-28	0.49	0.00	1.00	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	FKBP1B	0.04	0.02	blup	41	0.02	3.6e-05	12.73	-10.8	2.1e-27	-0.38	0.44	0.03	FALSE
11	GTEx	Artery Tibial	PFN4	0.09	0.04	enet	15	0.09	9.1e-08	12.73	10.6	3.0e-26	0.42	0.13	0.31	FALSE
13	GTEx	Brain Cerebellum	FKBP1B	0.25	0.01	enet	16	0.20	1.6e-06	12.73	9.7	2.3e-22	0.48	0.04	0.55	FALSE
49	METSIM	Adipose	FKBP1B	0.20	0.04	blup	334	0.10	6.5e-15	-5.99	-8.9	6.3e-19	-0.20	1.00	0.00	FALSE
51	METSIM	Adipose	UBXN2A	0.07	0.03	bslmm	403	0.06	5.3e-10	2.85	8.9	6.5e-19	0.78	0.14	0.86	FALSE
56	ROSMAP	Brain Pre-frontal Cortex	FAM228B	0.23	0.01	enet	51	0.14	5.2e-18	12.73	8.4	3.6e-17	0.44	0.61	0.39	FALSE
65	The Cancer Genome Atlas	Glioblastoma Multiforme	C2orf84	0.13	0.07	blup	56	0.05	1.5e-02	6.56	8.3	1.3e-16	0.51	0.02	0.29	FALSE
18	GTEx	Breast Mammary Tissue (Female)	PFN4	0.11	0.12	enet	16	0.09	1.0e-03	6.04	8.2	1.7e-16	0.49	0.05	0.23	FALSE
46	GTEx	Testis	AC009228.1	0.27	0.34	lasso	5	0.38	5.4e-18	9.91	8.2	2.5e-16	0.54	1.00	0.00	FALSE
32	GTEx	Esophagus Muscularis	AC009228.1	0.11	0.06	enet	16	0.12	9.9e-08	5.71	8.2	3.0e-16	0.62	0.58	0.41	FALSE
28	GTEx	Esophagus Mucosa	TP53I3	0.16	0.03	enet	23	0.06	8.2e-05	-5.44	7.5	6.0e-14	0.38	0.08	0.36	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	FKBP1B	0.06	0.03	lasso	9	0.04	2.0e-05	-7.40	7.3	3.3e-13	0.17	0.96	0.00	FALSE
63	The Cancer Genome Atlas	Esophageal Carcinoma	C2orf84	0.13	0.04	lasso	3	0.06	4.8e-03	3.89	6.8	7.6e-12	0.49	0.22	0.08	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	SF3B14	0.10	0.01	lasso	8	0.00	3.5e-01	6.86	6.8	9.1e-12	0.42	0.10	0.15	FALSE
29	GTEx	Esophagus Mucosa	UBXN2A	0.12	0.06	lasso	6	0.05	1.9e-04	-7.24	-6.7	1.8e-11	-0.16	0.72	0.01	FALSE
3	GTEx	Adipose Subcutaneous	PFN4	0.12	0.11	lasso	6	0.10	1.3e-08	-5.60	6.7	2.2e-11	0.22	1.00	0.00	FALSE
57	ROSMAP	Brain Pre-frontal Cortex	RP11-507M3.1	0.11	0.12	enet	17	0.14	6.4e-17	5.38	6.4	2.0e-10	0.48	1.00	0.00	FALSE
17	GTEx	Breast Mammary Tissue (Male)	FAM228B	0.04	-0.01	lasso	13	0.00	4.3e-01	-5.99	6.0	2.1e-09	0.13	0.05	0.06	FALSE
68	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TP53I3	0.07	0.08	lasso	4	0.08	6.3e-09	-5.99	6.0	2.3e-09	0.14	1.00	0.00	FALSE
78	The Cancer Genome Atlas	Lung Adenocarcinoma	UBXN2A	0.05	0.00	blup	46	0.01	1.3e-02	-0.74	6.0	2.4e-09	0.69	0.01	0.34	FALSE
16	GTEx	Breast Mammary Tissue (Male)	PFN4	0.07	0.02	enet	3	0.03	6.1e-02	-5.44	5.8	6.4e-09	0.17	0.02	0.24	FALSE
71	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FKBP1B	0.10	0.01	blup	41	0.02	3.9e-02	-5.59	-5.7	9.5e-09	-0.09	0.06	0.04	FALSE
62	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TP53I3	0.06	0.05	enet	8	0.04	2.9e-03	-5.60	5.6	1.8e-08	0.14	0.06	0.10	FALSE
48	GTEx	Thyroid	ITSN2	0.10	0.06	enet	21	0.06	3.1e-05	4.45	5.6	2.3e-08	0.45	0.97	0.00	FALSE
64	The Cancer Genome Atlas	Esophageal Carcinoma	LOC375190	0.12	0.13	lasso	1	0.11	2.2e-04	-5.59	5.6	2.3e-08	0.14	0.47	0.06	FALSE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FKBP1B	0.05	0.07	lasso	7	0.06	2.3e-07	-5.58	-5.6	2.3e-08	-0.14	1.00	0.00	FALSE
35	GTEx	Heart Atrial Appendage	FAM228B	0.21	0.21	lasso	15	0.17	3.0e-08	-5.44	5.6	2.4e-08	0.14	1.00	0.00	FALSE
76	The Cancer Genome Atlas	Lung Adenocarcinoma	C2orf84	0.10	0.14	lasso	8	0.15	6.2e-17	5.38	5.6	2.6e-08	0.44	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	FAM228B	0.08	0.09	lasso	5	0.09	1.0e-07	-5.49	5.6	2.7e-08	0.14	1.00	0.00	FALSE
9	GTEx	Artery Aorta	AC009228.1	0.10	0.06	lasso	2	0.04	4.4e-03	5.73	5.6	2.7e-08	0.41	0.63	0.02	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	FAM228B	0.20	0.19	enet	21	0.20	1.1e-07	-5.99	5.6	2.7e-08	0.15	0.97	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TP53I3	0.19	0.12	lasso	5	0.12	5.1e-15	-5.99	5.5	3.4e-08	0.12	1.00	0.00	FALSE
20	GTEx	Cells EBV-transformed lymphocytes	FAM228B	0.17	0.02	lasso	4	0.05	7.7e-03	-5.44	5.5	3.5e-08	0.14	0.49	0.03	FALSE
37	GTEx	Heart Left Ventricle	FAM228B	0.12	0.13	lasso	1	0.10	6.2e-06	-5.44	5.4	5.2e-08	0.14	0.81	0.01	FALSE
41	GTEx	Muscle Skeletal	FAM228B	0.08	0.12	lasso	1	0.11	2.7e-11	-5.44	5.4	5.2e-08	0.14	1.00	0.00	FALSE
45	GTEx	Skin Sun Exposed Lower leg	FAM228B	0.07	0.05	lasso	1	0.02	1.1e-02	-5.44	5.4	5.2e-08	0.14	0.22	0.03	FALSE
83	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LOC375190	0.23	0.19	lasso	1	0.18	1.5e-07	-5.44	5.4	5.2e-08	0.14	0.82	0.01	FALSE
85	The Cancer Genome Atlas	Rectum Adenocarcinoma	LOC375190	0.31	0.18	lasso	1	0.13	5.5e-04	-5.44	5.4	5.2e-08	0.14	0.08	0.06	FALSE
89	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	LOC375190	0.18	0.17	lasso	1	0.14	8.7e-05	-5.44	5.4	5.2e-08	0.14	0.40	0.03	FALSE
6	GTEx	Adipose Visceral Omentum	FAM228B	0.13	0.11	lasso	4	0.11	2.5e-06	-5.44	5.4	5.4e-08	0.16	0.86	0.01	FALSE
81	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LOC375190	0.20	0.20	lasso	2	0.18	7.8e-08	-5.44	5.4	5.4e-08	0.14	0.93	0.00	FALSE
10	GTEx	Artery Tibial	FKBP1B	0.10	0.06	lasso	5	0.04	4.4e-04	-5.45	-5.4	6.7e-08	-0.12	0.47	0.02	FALSE
12	GTEx	Artery Tibial	FAM228B	0.23	0.24	lasso	6	0.23	8.8e-18	-5.44	5.4	6.9e-08	0.14	1.00	0.00	FALSE
8	GTEx	Artery Aorta	TP53I3	0.10	0.03	lasso	2	0.01	5.1e-02	-5.44	5.4	7.4e-08	0.15	0.29	0.03	FALSE
43	GTEx	Ovary	FAM228B	0.21	0.05	lasso	2	0.01	2.1e-01	-5.44	5.3	9.0e-08	0.14	0.14	0.07	FALSE
73	The Cancer Genome Atlas	Brain Lower Grade Glioma	C2orf44	0.04	0.01	enet	8	0.02	1.1e-03	-5.58	-5.3	1.2e-07	-0.13	0.17	0.03	FALSE