TWAS hub - DNMT3A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Sigmoid	0.186	0.0780	0.00510	-0.008	NA	-0.005	NA	-0.003	0.940	NA	0.5200	NA	0.45000
2	YFS	Blood	0.037	0.0156	0.00081	0.002	0.011	0.005	0.012	0.009	0.048	9.7e-05	0.0054	4.2e-05	0.00041

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Waist Hip Ratio (WHR)	9.3	41.9	76.9	-8.8	2.6
Height	8.5	164.7	272.2	-16.5	-7.6
Standing height	8.4	82.9	139.2	-11.8	-5.2
Diabetes (self-reported)	8.0	12.4	18.0	-2.6	4.2
Comparative height size at age 10	7.7	42.6	82.6	-9.1	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	6.9	14.4	17.7	-4.2	-3.3
Diabetes diagnosed by doctor	5.5	9.0	12.8	-2.3	3.6
Trunk predicted mass	5.1	29.2	53.3	-7.3	-2.2
Trunk fat-free mass	5.0	28.6	52.0	-7.2	-2.3
Illnesses of siblings: Diabetes	4.7	5.8	9.5	-1.4	3.1
Medication: Metformin	4.5	6.3	9.6	-1.7	3.1
Arm predicted mass (left)	4.3	21.7	40.3	-6.3	-1.7
Average weekly spirits intake	4.2	5.2	8.7	-2.9	1.3
Headache pain in last month	4.1	7.0	13.6	-3.7	0.6
Arm fat-free mass (right)	4.0	20.5	39.3	-6.3	-1.3
Whole body water mass	4.0	22.8	41.9	-6.5	-1.9
Forced vital capacity (FVC)	3.9	15.1	18.1	-3.5	-4.2
Medication: Omeprazole	3.9	4.7	5.9	-2.4	1.8
Whole body fat-free mass	3.9	22.6	41.6	-6.5	-1.9
Arm fat-free mass (left)	3.9	19.6	37.1	-6.1	-1.4
Arm predicted mass (right)	3.8	19.3	36.5	-6.0	-1.4
Type 2 Diabetes (T2D) (2018)	3.7	6.8	7.1	-2.7	2.6
Ever used hormone-replacement therapy (HRT)	3.4	4.3	8.3	-2.9	0.6
Family relationship satisfaction	3.4	4.1	8.1	-2.8	0.4
Basal metabolic rate	3.4	18.8	33.4	-5.8	-2.1
Blood Red Count	3.3	31.8	62.3	-7.9	-1.1
Alzheimer’s Disease (in father)	3.2	3.4	5.6	2.4	1.1
Chronic bronchitis/emphysema (mother)	3.2	3.7	6.5	-2.5	-1.0
Medication: Bendroflumethiazide	3.2	4.8	8.8	-3.0	0.9
Forced vital capacity (FVC), Best measure	3.1	11.5	13.0	-3.1	-3.6
Medication: Blood pressure	3.0	5.3	8.2	-2.9	1.6
Medication: Omeprazole (e.g. Zanprol)	3.0	3.7	4.7	-2.2	1.6
Relative age voice broke	2.9	4.4	8.5	2.9	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.9	3.4	3.6	-1.8	1.9
Average weekly champagne plus white wine intake	2.9	4.0	7.9	0.2	-2.8
Alcohol drinker status: Never	2.9	3.4	6.4	-2.5	0.7
Systolic blood pressure, automated reading	2.8	8.3	15.6	-3.9	1.0
Bilateral oophorectomy (both ovaries removed)	2.8	3.2	6.4	-2.5	-0.1
Hand grip strength (right)	2.7	7.5	8.1	-2.8	-2.6
Forced expiratory volume in 1-second (FEV1)	2.7	9.0	13.8	-2.0	-3.7
Ever had prostate specific antigen (PSA) test	2.7	3.1	5.2	2.3	-1.0
Mouth/teeth dental problems: Dentures	2.6	4.4	4.5	-2.1	2.1
Suffer from ‘nerves’	2.6	4.0	6.0	-2.4	1.4
Body Mass Index (BMI) (2010)	2.5	3.4	6.8	2.6	-0.0
Diabetes (mother)	2.5	3.1	5.4	-0.9	2.3
High blood pressure	2.5	7.1	13.2	-3.6	0.9
Comparative body size at age 10	2.5	6.9	10.4	3.2	1.9
Hypertension (Self-reported)	2.5	7.0	13.5	-3.7	0.7
Number of operations (self-reported)	2.5	3.7	6.7	-2.6	-0.9
Leg fat-free mass (right)	2.4	12.7	22.8	-4.8	-1.6
Leg predicted mass (right)	2.4	12.7	22.6	-4.8	-1.7
Systolic Blood Pressure	2.3	11.5	22.9	-4.8	0.4
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	4.6	-0.7	2.1
Leg fat-free mass (left)	2.3	12.2	22.0	-4.7	-1.5
Leg predicted mass (left)	2.3	12.4	22.2	-4.7	-1.6
Worry (Nagel 2018)	2.2	4.7	7.4	-2.7	1.4
Bipolar Disorder (2011)	2.2	2.1	3.5	-1.9	-0.8
Hand grip strength (left)	2.2	5.9	6.4	-2.3	-2.5
Schizophrenia vs Biploar Disorder	2.1	2.7	4.7	2.2	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.6	9.9	-1.9	-3.1
Breastfed as a baby	2.1	2.6	3.2	-1.8	1.4
Peak expiratory flow (PEF)	2.1	5.0	6.4	-1.9	-2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	4.9	-0.7	2.2
Medication for pain relief, constipation, heartburn	2.1	3.7	6.6	2.6	0.9
Risk taking	2.1	3.0	5.2	2.3	-0.9
Lupus	2.0	3.0	5.8	-2.4	-0.5
Allergy or Eczema	2.0	5.2	10.2	-3.2	-0.5
Medication: Lansoprazole	2.0	2.3	3.2	-1.8	1.1
High blood pressure (siblings)	2.0	2.8	4.7	-2.2	1.0
Heel T-Score	1.9	15.1	15.5	3.9	3.8
Number of incorrect matches in round	1.9	3.1	5.7	0.7	-2.4
Tense / ‘highly strung’	1.9	3.1	6.1	-2.5	-0.2
Commuting to job workplace: Public transport	1.9	2.2	4.2	-2.1	0.5
Medication: Paracetamol	1.9	2.9	3.4	-1.9	-1.5
Diabetes (father)	1.8	2.3	4.5	0.2	2.1
Fluid intelligence score	1.8	3.7	7.1	-0.6	2.7
Alcohol intake frequency.	1.8	4.3	7.2	-2.7	1.2
Osteoporosis (self-reported)	1.8	2.2	4.4	-2.1	-0.2
Medication: Lisinopril	1.8	2.4	3.9	-0.9	2.0
Stomach or abdominal pain in last month	1.7	2.2	4.1	-2.0	0.5
Happiness	1.7	2.0	3.0	-1.7	1.0
Average weekly red wine intake	1.7	2.5	4.7	-0.5	-2.2
Ever had bowel cancer screening	1.7	2.0	3.3	-1.8	0.8
Wears glasses or contact lenses	1.7	1.9	2.2	-1.5	1.3
Cholesterol lowering medication	1.7	2.5	4.4	-2.1	0.8
Breast Cancer	1.6	4.0	6.9	2.6	-1.0
Hayfever, allergic rhinitis or eczema	1.6	3.4	6.7	-2.6	-0.3
Weight	1.6	7.7	12.4	-3.5	-1.7
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	3.0	0.9	1.7
Vascular/heart problems diagnosed by doctor	1.6	4.4	8.2	2.9	-0.8
Supplements: Calcium	1.6	1.8	2.6	-1.0	-1.6
Townsend deprivation index at recruitment	1.5	2.1	3.8	-0.6	1.9
Sitting height	1.5	10.8	21.5	-4.6	0.1
Financial difficulties in last 2 years	1.5	2.0	2.1	1.5	1.4
Medication: Simvastatin	1.5	2.2	2.5	-1.6	1.4
Friendships satisfaction	1.5	1.8	3.0	-1.7	0.8
Smoking Status	1.4	3.3	5.7	2.4	-1.0
Chronotype (morning person)	1.4	3.3	3.4	-1.8	1.9
Number of treatments/medications taken	1.4	2.5	4.8	-2.2	0.4
Waist circumference	1.4	5.3	10.5	-3.2	0.2
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	2.5	1.6	-1.4
Health satisfaction	1.4	1.8	2.5	-1.6	1.1
Mood swings	1.4	2.5	4.8	0.5	-2.2
Bipolar Disorder (2018)	1.3	2.1	2.9	-1.1	-1.7
Lung FEV1/FVC ratio	1.3	6.4	12.8	3.6	-0.2
Medication: Atenolol	1.3	1.6	2.3	-1.5	1.0
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	4.0	-2.0	-0.1
Hair/balding pattern: Pattern 3	1.3	1.9	2.7	1.1	-1.6
Depression (self-reported)	1.3	1.6	3.0	0.4	1.7
Worry too long after embarrassment	1.3	2.1	2.9	-1.1	-1.7
Mouth/teeth dental problems: Loose teeth	1.3	1.5	3.1	1.8	-0.0
Osteoarthritis (self-reported)	1.3	1.7	3.4	0.1	-1.8
Ovarian Cancer	1.2	1.6	2.9	0.6	1.7
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.4	1.6	-0.5
Mouth/teeth dental problems	1.2	1.8	2.8	1.7	-0.8
Illnesses of siblings	1.2	1.7	1.7	1.3	-1.3
Length of working week for main job	1.2	1.3	2.4	-1.5	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	3.5	-0.2	1.9
Medication: Paracetamol	1.2	2.0	2.1	-1.4	-1.5
Migraine (self-reported)	1.2	1.5	2.3	-1.5	-0.8
Myopia	1.2	1.8	3.4	0.3	1.9
Medication: Ibuprofen	1.1	1.3	2.3	-1.5	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	2.2	-1.5	-0.6
Illnesses of father: High blood pressure	1.1	1.3	1.8	-1.3	-0.9
Fractured/broken bones in last 5 years	1.1	1.4	2.2	-0.7	-1.5
Diastolic blood pressure, automated reading	1.1	3.5	6.8	-2.6	0.5
Depression (Nagel 2018)	1.0	1.4	2.1	-0.9	1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	3.1	1.2	1.8
Alcohol usually taken with meals	1.0	1.7	2.9	-0.6	-1.7
Qualifications: A levels/AS levels or equivalent	1.0	2.3	4.5	-2.1	0.2
Medication: Allopurinol	1.0	1.4	2.5	0.5	1.6
Heart disease (mother)	1.0	1.2	1.6	-1.3	-0.9
Supplements: Fish oil (including cod liver oil)	1.0	1.3	1.5	-1.1	1.2
Crohns Disease (2012)	0.9	1.4	2.1	-1.4	-0.9
Cardiovascular Disease	0.9	3.1	5.6	-2.4	0.7
Taking other prescription medications	0.9	1.4	1.6	-1.1	1.3
Hair/balding pattern: Pattern 2	0.9	1.2	2.3	1.5	0.2
Qualifications: None of the above	0.9	1.9	2.6	1.1	-1.6
Ever highly irritable/argumentative for 2 days	0.9	1.1	1.8	-1.4	0.5
Medication: Amlodipine	0.9	1.3	2.1	-1.5	0.6
Overall health rating	0.9	1.9	3.5	-1.9	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	1.9	-1.4	0.1
Illnesses of father: None of the above (group 1)	0.9	1.1	1.5	-0.8	1.2
Number of self-reported non-cancer illnesses	0.9	1.6	2.9	-1.7	0.5
Guilty feelings	0.9	1.4	1.8	-1.3	-1.0
High cholesterol (Self-reported)	0.9	1.7	2.2	-1.5	1.0
Prostate Cancer	0.8	1.2	2.3	1.5	0.2
Mean Putamen Volume	0.8	0.9	1.6	-0.4	1.2
LDL Cholesterol	0.8	1.3	2.6	0.2	1.6
Blood White Count	0.8	6.0	8.1	-2.0	-2.8
Lung FVC	0.8	4.1	7.1	1.1	-2.7
Hearing difficulty/problems: Yes	0.8	1.3	1.4	1.2	-1.1
Number of live births	0.8	1.1	2.3	1.5	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.6	-1.3	-0.6
Impedance of arm (left)	0.8	3.6	6.8	0.6	-2.6
Angina (self-reported)	0.8	1.0	2.0	1.4	-0.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.5	-0.7	1.2
Back pain experienced in last month	0.8	1.1	2.1	-0.4	-1.4
Mineral and other dietary supplements	0.8	1.1	1.3	1.2	0.9
Smoking status: Current	0.8	1.2	1.8	1.3	-0.8
Age started oral contraceptive pill	0.8	1.0	1.9	0.4	1.4
Pain experienced in last month	0.8	1.3	1.3	1.1	1.1
Crohns Disease (2017)	0.7	1.5	1.6	-1.2	-1.3
Rheumatoid Arthritis	0.7	1.0	1.0	1.0	-1.0
Relative age of first facial hair	0.7	1.4	2.5	1.6	0.5
Angina	0.7	0.9	1.7	1.3	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.9	-0.2	1.4
Had menopause	0.7	0.9	1.5	-0.5	1.2
Had other major operations	0.7	0.8	1.4	-1.2	-0.4
Arm fat percentage (right)	0.7	2.6	5.0	2.2	-0.5
Medication: Cholesterol lowering	0.7	1.1	2.2	0.1	1.5
Illnesses of mother	0.7	0.9	1.7	1.3	-0.3
Hair/balding pattern: Pattern 4	0.7	1.7	2.7	1.6	-0.8
Loud music exposure frequency	0.7	0.8	1.4	1.2	0.3
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.4	-1.2	0.6
Birth weight	0.7	1.6	2.9	-1.7	0.5
Eye problems/disorders: None of the above	0.7	0.8	1.1	0.7	-1.1
Knee pain experienced in last month	0.7	1.1	1.2	-1.1	-1.0
Qualifications: nursing, teaching	0.7	1.0	1.2	-1.1	-0.9
Eye problems/disorders: Cataract	0.7	0.8	1.1	-0.7	1.1
Medication: Gliclazide	0.7	0.8	1.5	-1.2	0.4
Irritability	0.7	1.1	2.1	-0.4	-1.5
Reaction Time	0.6	1.1	2.2	-0.0	-1.5
HDL Cholesterol	0.6	1.0	1.1	1.1	-1.0
Neuroticism (2016)	0.6	0.9	1.6	-1.3	0.4
Hypothyroidism (self reported)	0.6	1.4	2.6	0.4	1.6
Tanning	0.6	7.9	15.5	-3.9	-0.5
Current tobacco smoking	0.6	0.9	1.5	1.2	-0.6
Supplements: Glucosamine	0.6	0.8	1.0	-0.8	-1.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	1.1	-1.1	0.6
Time employed in main current job	0.6	0.6	1.3	-1.1	0.0
Worrier / anxious feelings	0.6	1.1	1.9	-1.4	-0.5
Noisy workplace	0.6	0.8	0.8	0.9	-0.9
Lung cancer (father)	0.6	0.7	0.7	-0.9	0.8
Emphysema/chronic bronchitis	0.6	0.7	1.3	0.2	-1.1
Chest pain or discomfort	0.6	0.9	1.3	0.7	-1.1
Arm fat percentage (left)	0.6	2.5	4.8	2.2	-0.5
Long-standing illness, disability or infirmity	0.6	1.0	1.5	-1.2	0.6
Financial situation satisfaction	0.6	0.7	1.2	0.5	1.1
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.3	0.3	1.5
Fasting Glucose	0.5	0.7	1.3	-0.1	1.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	0.7	-0.8	0.6
BMI	0.5	2.9	5.3	2.3	-0.7
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.0	-1.0	0.7
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.4	-1.2	0.2
Ever had hysterectomy (womb removed)	0.5	0.6	1.2	-1.1	-0.1
Qualifications: CSEs or equivalent	0.5	0.6	1.0	1.0	-0.5
Body mass index (BMI)	0.5	2.0	3.7	1.9	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	1.3	1.1	1.0
Allergy	0.5	1.2	2.2	1.5	-0.5
Impedance of arm (right)	0.5	2.5	4.1	1.0	-2.0
Falls in the last year	0.5	0.7	1.1	-0.6	-1.1
Asthma	0.5	1.0	1.3	-0.9	1.1
Birth weight of first child	0.5	0.9	1.7	-1.3	0.5
Pulse wave reflection index	0.5	0.7	0.9	-0.9	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.2	-0.1	1.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.7	0.8	0.6
Asthma (self-reported)	0.5	0.9	1.3	-0.7	1.1
Ever smoked	0.5	0.9	1.5	1.2	-0.6
Leg fat percentage (left)	0.5	1.9	3.8	2.0	-0.2
Basal cell carcinoma (self-reported)	0.5	0.6	0.8	0.9	-0.7
Neuroticism (Nagel 2018)	0.4	1.0	1.6	-1.3	0.6
Major Depression (MDD)	0.4	0.5	1.1	-0.1	-1.0
Age at First Birth	0.4	0.5	1.0	-0.1	1.0
Respiratory disease	0.4	0.9	1.2	-0.7	1.1
Severe depression (siblings)	0.4	0.5	0.9	-0.1	1.0
Fed-up feelings	0.4	0.7	1.0	-0.7	1.0
Age when periods started (menarche)	0.4	0.9	1.0	1.0	-1.0
Trunk fat mass	0.4	1.6	2.1	-1.4	-1.1
Hip circumference	0.4	1.9	3.8	-0.2	-1.9
Prospective memory result	0.4	0.5	1.1	-0.1	-1.0
Leg fat percentage (right)	0.4	1.4	2.8	1.7	-0.3
Number of full brothers	0.4	0.5	1.0	1.0	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.9	0.2	-1.0
Qualifications: College or University degree	0.4	1.2	2.2	-1.5	0.3
Medication: Seretide 50 evohaler	0.4	0.5	0.5	0.7	0.7
Number of full sisters	0.4	0.5	0.7	0.9	0.6
Loneliness, isolation	0.4	0.5	0.7	0.9	0.5
Miserableness	0.4	0.8	1.3	1.1	-0.5
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.9	0.1	-1.0
Impedance of whole body	0.4	1.9	3.5	0.5	-1.9
Schizophrenia (2018)	0.3	0.6	1.1	0.0	1.1
Alzheimer’s Disease (including proxy)	0.3	0.4	0.5	0.7	-0.5
Irritable Bowel Disease (IBD)	0.3	0.6	0.7	-0.8	-0.7
Schizophrenia (2014)	0.3	0.6	0.7	-0.6	0.8
Blood Platelet Count	0.3	3.7	4.5	2.1	1.7
Medication for hormone replacement therapy	0.3	0.4	0.7	-0.8	-0.1
Impedance of leg (right)	0.3	1.6	3.1	-0.4	-1.8
Impedance of leg (left)	0.3	1.4	2.7	-0.2	-1.6
Alcohol intake versus 10 years previously	0.3	0.4	0.5	-0.7	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.1	-0.2	1.1
Pulse rate	0.3	0.6	1.1	0.2	1.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.7	-0.2	-0.8
Body fat percentage	0.3	1.0	1.4	1.2	-0.8
Exposure to tobacco smoke outside home	0.3	0.5	0.9	-1.0	-0.1
Shortness of breath walking on level ground	0.3	0.4	0.8	-0.2	-0.9
Whole body fat mass	0.3	1.2	1.3	-1.1	-1.0
Age at last live birth	0.3	0.5	0.9	-0.1	-0.9
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.5	0.7	-0.4
Medication: Aspirin	0.3	0.5	0.9	-0.9	0.1
Supplements: Vitamin C	0.3	0.4	0.4	-0.6	-0.6
Breast cancer (self-reported)	0.3	0.3	0.6	-0.8	-0.2
Hearing aid user	0.3	0.3	0.6	0.8	0.1
Medication: Blood pressure	0.3	0.5	1.0	-1.0	0.2
Medication: Atorvastatin	0.3	0.3	0.6	0.8	0.2
Commuting to job workplace: Cycle	0.3	0.4	0.5	0.5	-0.7
Heart disease (siblings)	0.3	0.4	0.6	0.5	0.7
Depressed Affect (Nagel 2018)	0.2	0.4	0.5	0.5	0.7
HbA1C	0.2	0.3	0.5	0.7	0.1
Triglycerides	0.2	0.4	0.4	-0.6	0.6
Blood Eosinophil Count	0.2	1.3	1.8	-1.3	-0.9
Vitamin and mineral supplements	0.2	0.2	0.3	0.3	0.6
Medication: Co-codamol	0.2	0.3	0.5	-0.2	0.7
Multivitamins +/- minerals	0.2	0.3	0.5	-0.7	0.3
Nervous feelings	0.2	0.3	0.6	-0.7	-0.3
Hearing difficulty/problems with background noise	0.2	0.3	0.4	0.4	-0.6
Pain all over the body in last month	0.2	0.2	0.4	0.2	0.6
Neuroticism score	0.2	0.4	0.4	-0.7	-0.5
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	-0.7	-0.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.7	-0.8	0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.6	0.5	0.7
Leg pain on walking	0.2	0.2	0.3	-0.4	-0.5
Commuting to job workplace: Walk	0.2	0.2	0.3	0.4	0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.4	-0.4	-0.7
Medication for cholesterol	0.2	0.4	0.6	0.8	-0.3
Medication: Aspirin	0.2	0.2	0.5	-0.7	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.9	-0.1	-0.9
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	-0.6	-0.1
Ever depressed for a whole week	0.2	0.3	0.4	-0.6	0.4
Unable to work because of sickness or disability	0.2	0.2	0.3	-0.5	0.3
Alcohol drinker status: Previous	0.2	0.2	0.3	0.5	0.3
Pack years of smoking	0.2	0.3	0.5	-0.7	-0.0
Bipolar Disorder or Schizophrenia	0.1	0.3	0.5	-0.7	-0.2
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.3	-0.6	0.1
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	-0.4	-0.1
Ulcerative Colitis (UC)	0.1	0.1	0.2	0.2	0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.2	-0.0	-0.5
Primary Biliary Cirrhosis	0.1	0.1	0.3	0.1	0.5
Ulcerative Colitis	0.1	0.2	0.4	0.2	0.6
Neuroticism	0.1	0.3	0.4	-0.6	0.5
Hair Pigment	0.1	2.0	3.0	1.0	-1.7
Sensitivity / hurt feelings	0.1	0.2	0.2	0.4	-0.5
Supplements: Zinc	0.1	0.1	0.2	-0.3	-0.4
Pack years adult smoking proportion	0.1	0.1	0.2	-0.4	-0.2
Trunk fat percentage	0.1	0.3	0.6	0.3	-0.8
Serious illness, injury or assault to yourself	0.1	0.2	0.3	0.6	0.0
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	0.3	-0.3
Medication: Levothyroxine sodium	0.1	0.1	0.1	-0.4	0.3
Chronic bronchitis/emphysema (father)	0.1	0.2	0.2	-0.3	-0.5
High blood pressure (mother)	0.1	0.1	0.1	-0.4	0.2
Past tobacco smoking	0.1	0.2	0.2	-0.5	0.5
Heart attack	0.1	0.2	0.4	0.6	-0.0
Father’s age at death	0.1	0.1	0.2	0.4	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.3	-0.5	-0.2
Arm fat mass (right)	0.1	0.3	0.5	-0.2	-0.7
Exposure to tobacco smoke at home	0.1	0.1	0.1	-0.3	-0.3
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.2	-0.4
Gout (self-reported)	0.1	0.1	0.1	-0.3	0.3
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.4	-0.1
Mean time to correctly identify matches	0.1	0.2	0.3	-0.6	-0.4
Had major operations	0.1	0.1	0.1	-0.3	0.4
Illnesses of father: Heart disease	0.1	0.2	0.4	0.6	-0.2
Smoking status: Previous	0.1	0.1	0.2	0.4	-0.2
Arm fat mass (left)	0.1	0.3	0.6	-0.2	-0.7
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	0.6	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.1	-0.3	-0.2
Average weekly fortified wine intake	0.0	0.0	0.0	0.2	0.0
Maternal smoking around birth	0.0	0.0	0.0	-0.2	-0.0
Ever unenthusiastic/disinterested for a whole week	0.0	0.1	0.1	-0.2	0.3
Medication: Ramipril	0.0	0.0	0.1	0.3	0.1
Glaucoma (self-reported)	0.0	0.0	0.0	-0.1	0.0
Wheeze or whistling in the chest in last year	0.0	0.0	0.0	-0.1	-0.1
Number of children fathered	0.0	0.0	0.0	0.2	-0.1
Age at first live birth	0.0	0.0	0.0	-0.0	-0.1
Pulse wave peak to peak time	0.0	0.0	0.0	-0.2	-0.2
Leg fat mass (right)	0.0	0.1	0.2	-0.1	-0.5
Pulse rate, automated reading	0.0	0.1	0.2	-0.5	-0.2
Ever taken oral contraceptive pill	0.0	0.0	0.1	-0.0	-0.3
Mother’s age at death	0.0	0.0	0.0	0.1	0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	-0.1	-0.0
Average weekly beer plus cider intake	0.0	0.0	0.1	0.2	-0.1
Leg fat mass (left)	0.0	0.1	0.2	0.1	-0.5

Hub : Genes

DNMT3A

Models

Trait associations