Hub : Genes

DNMT3A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Colon Sigmoid 0.186 0.0780 0.00510 -0.008 NA -0.005 NA -0.003 0.940 NA 0.5200 NA 0.45000
2 YFS Blood 0.037 0.0156 0.00081 0.002 0.011 0.005 0.012 0.009 0.048 9.7e-05 0.0054 4.2e-05 0.00041

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.3 2.1 2.9 -1.1 -1.7
Bipolar Disorder or Schizophrenia 0.1 0.3 0.5 -0.7 -0.2
Depressed Affect (Nagel 2018) 0.2 0.4 0.5 0.5 0.7
Depression (Nagel 2018) 1.0 1.4 2.1 -0.9 1.5
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.3 -0.6 0.1
Neuroticism (Nagel 2018) 0.4 1.0 1.6 -1.3 0.6
Schizophrenia (2018) 0.3 0.6 1.1 0.0 1.1
Schizophrenia vs Biploar Disorder 2.1 2.7 4.7 2.2 0.9
Worry (Nagel 2018) 2.2 4.7 7.4 -2.7 1.4
Alzheimer’s Disease (in mother) 0.1 0.1 0.1 -0.4 -0.1
Alzheimer’s Disease (in father) 3.2 3.4 5.6 2.4 1.1
Alzheimer’s Disease (including proxy) 0.3 0.4 0.5 0.7 -0.5
Crohns Disease (2017) 0.7 1.5 1.6 -1.2 -1.3
Irritable Bowel Disease (IBD) 0.3 0.6 0.7 -0.8 -0.7
Ulcerative Colitis (UC) 0.1 0.1 0.2 0.2 0.4
Major Depression (MDD) 0.4 0.5 1.1 -0.1 -1.0
Reaction Time 0.6 1.1 2.2 -0.0 -1.5
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.3 0.3 1.5
Breast Cancer 1.6 4.0 6.9 2.6 -1.0
Ovarian Cancer 1.2 1.6 2.9 0.6 1.7
Prostate Cancer 0.8 1.2 2.3 1.5 0.2
Age at First Birth 0.4 0.5 1.0 -0.1 1.0
Bipolar Disorder (2011) 2.2 2.1 3.5 -1.9 -0.8
Body Mass Index (BMI) (2010) 2.5 3.4 6.8 2.6 -0.0
Coronary Artery Disease (CAD) 0.1 0.1 0.2 -0.0 -0.5
Crohns Disease (2012) 0.9 1.4 2.1 -1.4 -0.9
Mean Putamen Volume 0.8 0.9 1.6 -0.4 1.2
Fasting Glucose 0.5 0.7 1.3 -0.1 1.1
HbA1C 0.2 0.3 0.5 0.7 0.1
HDL Cholesterol 0.6 1.0 1.1 1.1 -1.0
LDL Cholesterol 0.8 1.3 2.6 0.2 1.6
Lupus 2.0 3.0 5.8 -2.4 -0.5
Neuroticism (2016) 0.6 0.9 1.6 -1.3 0.4
Primary Biliary Cirrhosis 0.1 0.1 0.3 0.1 0.5
Rheumatoid Arthritis 0.7 1.0 1.0 1.0 -1.0
Schizophrenia (2014) 0.3 0.6 0.7 -0.6 0.8
Triglycerides 0.2 0.4 0.4 -0.6 0.6
Type 2 Diabetes (T2D) (2012) 0.5 0.6 0.7 -0.8 0.6
Ulcerative Colitis 0.1 0.2 0.4 0.2 0.6
Blood Eosinophil Count 0.2 1.3 1.8 -1.3 -0.9
Blood Platelet Count 0.3 3.7 4.5 2.1 1.7
Blood Red Count 3.3 31.8 62.3 -7.9 -1.1
Blood White Count 0.8 6.0 8.1 -2.0 -2.8
Heel T-Score 1.9 15.1 15.5 3.9 3.8
BMI 0.5 2.9 5.3 2.3 -0.7
Height 8.5 164.7 272.2 -16.5 -7.6
Waist Hip Ratio (WHR) 9.3 41.9 76.9 -8.8 2.6
Systolic Blood Pressure 2.3 11.5 22.9 -4.8 0.4
Smoking Status 1.4 3.3 5.7 2.4 -1.0
Allergy or Eczema 2.0 5.2 10.2 -3.2 -0.5
Cardiovascular Disease 0.9 3.1 5.6 -2.4 0.7
Hypothyroidism (self reported) 0.6 1.4 2.6 0.4 1.6
Respiratory disease 0.4 0.9 1.2 -0.7 1.1
Type 2 Diabetes (T2D) (2018) 3.7 6.8 7.1 -2.7 2.6
Lung FEV1/FVC ratio 1.3 6.4 12.8 3.6 -0.2
Lung FVC 0.8 4.1 7.1 1.1 -2.7
Neuroticism 0.1 0.3 0.4 -0.6 0.5
Chronotype (morning person) 1.4 3.3 3.4 -1.8 1.9
Hair Pigment 0.1 2.0 3.0 1.0 -1.7
Tanning 0.6 7.9 15.5 -3.9 -0.5
Hand grip strength (left) 2.2 5.9 6.4 -2.3 -2.5
Number of treatments/medications taken 1.4 2.5 4.8 -2.2 0.4
Average weekly spirits intake 4.2 5.2 8.7 -2.9 1.3
Sensitivity / hurt feelings 0.1 0.2 0.2 0.4 -0.5
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.0 -1.0 0.7
Hearing difficulty/problems: Yes 0.8 1.3 1.4 1.2 -1.1
Relative age of first facial hair 0.7 1.4 2.5 1.6 0.5
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.4 -1.2 0.2
Ever used hormone-replacement therapy (HRT) 3.4 4.3 8.3 -2.9 0.6
Ever had hysterectomy (womb removed) 0.5 0.6 1.2 -1.1 -0.1
Systolic blood pressure, automated reading 2.8 8.3 15.6 -3.9 1.0
Eye problems/disorders: Diabetes related eye disease 2.3 2.5 4.6 -0.7 2.1
Angina 0.7 0.9 1.7 1.3 -0.3
Medication for hormone replacement therapy 0.3 0.4 0.7 -0.8 -0.1
Vitamin and mineral supplements 0.2 0.2 0.3 0.3 0.6
Supplements: Zinc 0.1 0.1 0.2 -0.3 -0.4
Medication: Co-codamol 0.2 0.3 0.5 -0.2 0.7
Medication: Metformin 4.5 6.3 9.6 -1.7 3.1
Diabetes (father) 1.8 2.3 4.5 0.2 2.1
Diabetes (mother) 2.5 3.1 5.4 -0.9 2.3
Severe depression (siblings) 0.4 0.5 0.9 -0.1 1.0
Pack years adult smoking proportion 0.1 0.1 0.2 -0.4 -0.2
Impedance of leg (right) 0.3 1.6 3.1 -0.4 -1.8
Leg fat-free mass (left) 2.3 12.2 22.0 -4.7 -1.5
Trunk fat percentage 0.1 0.3 0.6 0.3 -0.8
Hand grip strength (right) 2.7 7.5 8.1 -2.8 -2.6
Townsend deprivation index at recruitment 1.5 2.1 3.8 -0.6 1.9
Current tobacco smoking 0.6 0.9 1.5 1.2 -0.6
Average weekly fortified wine intake 0.0 0.0 0.0 0.2 0.0
Maternal smoking around birth 0.0 0.0 0.0 -0.2 -0.0
Fed-up feelings 0.4 0.7 1.0 -0.7 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 1.9 -0.2 1.4
Relative age voice broke 2.9 4.4 8.5 2.9 -0.5
Taking other prescription medications 0.9 1.4 1.6 -1.1 1.3
Age when periods started (menarche) 0.4 0.9 1.0 1.0 -1.0
Bilateral oophorectomy (both ovaries removed) 2.8 3.2 6.4 -2.5 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 3.1 1.2 1.8
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 2.4 1.6 -0.5
Qualifications: CSEs or equivalent 0.5 0.6 1.0 1.0 -0.5
Serious illness, injury or assault to yourself 0.1 0.2 0.3 0.6 0.0
High blood pressure 2.5 7.1 13.2 -3.6 0.9
Hayfever, allergic rhinitis or eczema 1.6 3.4 6.7 -2.6 -0.3
Multivitamins +/- minerals 0.2 0.3 0.5 -0.7 0.3
Stomach or abdominal pain in last month 1.7 2.2 4.1 -2.0 0.5
Supplements: Glucosamine 0.6 0.8 1.0 -0.8 -1.0
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.1 0.3 -0.3
Medication: Atenolol 1.3 1.6 2.3 -1.5 1.0
Medication: Levothyroxine sodium 0.1 0.1 0.1 -0.4 0.3
Sitting height 1.5 10.8 21.5 -4.6 0.1
Chronic bronchitis/emphysema (father) 0.1 0.2 0.2 -0.3 -0.5
High blood pressure (mother) 0.1 0.1 0.1 -0.4 0.2
Body mass index (BMI) 0.5 2.0 3.7 1.9 0.6
Impedance of leg (left) 0.3 1.4 2.7 -0.2 -1.6
Leg predicted mass (left) 2.3 12.4 22.2 -4.7 -1.6
Trunk fat mass 0.4 1.6 2.1 -1.4 -1.1
Waist circumference 1.4 5.3 10.5 -3.2 0.2
Number of incorrect matches in round 1.9 3.1 5.7 0.7 -2.4
Past tobacco smoking 0.1 0.2 0.2 -0.5 0.5
Alcohol usually taken with meals 1.0 1.7 2.9 -0.6 -1.7
Nervous feelings 0.2 0.3 0.6 -0.7 -0.3
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.0 4.0 -2.0 -0.1
Hearing difficulty/problems with background noise 0.2 0.3 0.4 0.4 -0.6
Hair/balding pattern: Pattern 2 0.9 1.2 2.3 1.5 0.2
Had menopause 0.7 0.9 1.5 -0.5 1.2
Had other major operations 0.7 0.8 1.4 -1.2 -0.4
Forced vital capacity (FVC) 3.9 15.1 18.1 -3.5 -4.2
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 1.3 1.1 1.0
Ever unenthusiastic/disinterested for a whole week 0.0 0.1 0.1 -0.2 0.3
Qualifications: None of the above 0.9 1.9 2.6 1.1 -1.6
Financial difficulties in last 2 years 1.5 2.0 2.1 1.5 1.4
Mouth/teeth dental problems 1.2 1.8 2.8 1.7 -0.8
Heart attack 0.1 0.2 0.4 0.6 -0.0
Allergy 0.5 1.2 2.2 1.5 -0.5
Pain all over the body in last month 0.2 0.2 0.4 0.2 0.6
Diabetes (self-reported) 8.0 12.4 18.0 -2.6 4.2
Hayfever/allergic rhinitis (self-reported) 0.6 0.7 1.1 -1.1 0.6
Medication: Ramipril 0.0 0.0 0.1 0.3 0.1
Medication: Simvastatin 1.5 2.2 2.5 -1.6 1.4
Fluid intelligence score 1.8 3.7 7.1 -0.6 2.7
Illnesses of siblings 1.2 1.7 1.7 1.3 -1.3
Neuroticism score 0.2 0.4 0.4 -0.7 -0.5
Weight 1.6 7.7 12.4 -3.5 -1.7
Impedance of arm (right) 0.5 2.5 4.1 1.0 -2.0
Arm fat percentage (right) 0.7 2.6 5.0 2.2 -0.5
Trunk fat-free mass 5.0 28.6 52.0 -7.2 -2.3
Hip circumference 0.4 1.9 3.8 -0.2 -1.9
Time employed in main current job 0.6 0.6 1.3 -1.1 0.0
Alcohol intake versus 10 years previously 0.3 0.4 0.5 -0.7 0.6
Father’s age at death 0.1 0.1 0.2 0.4 -0.0
Worrier / anxious feelings 0.6 1.1 1.9 -1.4 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.6 1.1 -0.2 1.1
Falls in the last year 0.5 0.7 1.1 -0.6 -1.1
Hair/balding pattern: Pattern 3 1.3 1.9 2.7 1.1 -1.6
Number of live births 0.8 1.1 2.3 1.5 0.1
Forced expiratory volume in 1-second (FEV1) 2.7 9.0 13.8 -2.0 -3.7
Pulse rate 0.3 0.6 1.1 0.2 1.1
Happiness 1.7 2.0 3.0 -1.7 1.0
Noisy workplace 0.6 0.8 0.8 0.9 -0.9
Qualifications: A levels/AS levels or equivalent 1.0 2.3 4.5 -2.1 0.2
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.3 -0.5 -0.2
Mouth/teeth dental problems: Dentures 2.6 4.4 4.5 -2.1 2.1
Asthma 0.5 1.0 1.3 -0.9 1.1
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 1.6 -1.3 -0.6
Medication: Cholesterol lowering 0.7 1.1 2.2 0.1 1.5
Depression (self-reported) 1.3 1.6 3.0 0.4 1.7
Medication: Lansoprazole 2.0 2.3 3.2 -1.8 1.1
Prospective memory result 0.4 0.5 1.1 -0.1 -1.0
Lung cancer (father) 0.6 0.7 0.7 -0.9 0.8
Illnesses of mother 0.7 0.9 1.7 1.3 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 2.1 6.6 9.9 -1.9 -3.1
Pulse wave Arterial Stiffness index 0.2 0.2 0.4 -0.7 -0.0
Impedance of arm (left) 0.8 3.6 6.8 0.6 -2.6
Arm fat mass (right) 0.1 0.3 0.5 -0.2 -0.7
Trunk predicted mass 5.1 29.2 53.3 -7.3 -2.2
Standing height 8.4 82.9 139.2 -11.8 -5.2
Length of working week for main job 1.2 1.3 2.4 -1.5 -0.4
Exposure to tobacco smoke at home 0.1 0.1 0.1 -0.3 -0.3
Breastfed as a baby 2.1 2.6 3.2 -1.8 1.4
Tense / ‘highly strung’ 1.9 3.1 6.1 -2.5 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 3.5 -0.2 1.9
Hair/balding pattern: Pattern 4 0.7 1.7 2.7 1.6 -0.8
Birth weight of first child 0.5 0.9 1.7 -1.3 0.5
Peak expiratory flow (PEF) 2.1 5.0 6.4 -1.9 -2.5
Pulse wave reflection index 0.5 0.7 0.9 -0.9 -0.7
Ever highly irritable/argumentative for 2 days 0.9 1.1 1.8 -1.4 0.5
Loud music exposure frequency 0.7 0.8 1.4 1.2 0.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 0.7 -0.8 0.2
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 1.4 -1.2 0.6
Blood clot in the leg (DVT) 0.1 0.1 0.2 0.2 -0.4
Medication: Paracetamol 1.2 2.0 2.1 -1.4 -1.5
Headache pain in last month 4.1 7.0 13.6 -3.7 0.6
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 2.5 1.6 -1.4
Glaucoma (self-reported) 0.0 0.0 0.0 -0.1 0.0
Gout (self-reported) 0.1 0.1 0.1 -0.3 0.3
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.6 0.5 0.7
Medication: Amlodipine 0.9 1.3 2.1 -1.5 0.6
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.7 -0.2 -0.8
Birth weight 0.7 1.6 2.9 -1.7 0.5
Chronic bronchitis/emphysema (mother) 3.2 3.7 6.5 -2.5 -1.0
High blood pressure (siblings) 2.0 2.8 4.7 -2.2 1.0
Forced vital capacity (FVC), Best measure 3.1 11.5 13.0 -3.1 -3.6
Body fat percentage 0.3 1.0 1.4 1.2 -0.8
Leg fat percentage (right) 0.4 1.4 2.8 1.7 -0.3
Arm fat-free mass (right) 4.0 20.5 39.3 -6.3 -1.3
Exposure to tobacco smoke outside home 0.3 0.5 0.9 -1.0 -0.1
Comparative body size at age 10 2.5 6.9 10.4 3.2 1.9
Number of full brothers 0.4 0.5 1.0 1.0 -0.1
Worry too long after embarrassment 1.3 2.1 2.9 -1.1 -1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 2.1 2.7 4.9 -0.7 2.2
Wheeze or whistling in the chest in last year 0.0 0.0 0.0 -0.1 -0.1
Number of children fathered 0.0 0.0 0.0 0.2 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 0.9 0.2 -1.0
Age at first live birth 0.0 0.0 0.0 -0.0 -0.1
Pulse wave peak to peak time 0.0 0.0 0.0 -0.2 -0.2
Health satisfaction 1.4 1.8 2.5 -1.6 1.1
Shortness of breath walking on level ground 0.3 0.4 0.8 -0.2 -0.9
Qualifications: College or University degree 0.4 1.2 2.2 -1.5 0.3
Eye problems/disorders: None of the above 0.7 0.8 1.1 0.7 -1.1
Mouth/teeth dental problems: Loose teeth 1.3 1.5 3.1 1.8 -0.0
Emphysema/chronic bronchitis 0.6 0.7 1.3 0.2 -1.1
Medication for pain relief, constipation, heartburn 2.1 3.7 6.6 2.6 0.9
Neck or shoulder pain in last month 0.1 0.1 0.2 -0.4 -0.1
Medication: Blood pressure 3.0 5.3 8.2 -2.9 1.6
Angina (self-reported) 0.8 1.0 2.0 1.4 -0.1
Migraine (self-reported) 1.2 1.5 2.3 -1.5 -0.8
Medication: Ibuprofen 1.1 1.3 2.3 -1.5 -0.5
Medication: Allopurinol 1.0 1.4 2.5 0.5 1.6
Medication: Omeprazole 3.9 4.7 5.9 -2.4 1.8
Medication: Seretide 50 evohaler 0.4 0.5 0.5 0.7 0.7
Mean time to correctly identify matches 0.1 0.2 0.3 -0.6 -0.4
Heart disease (mother) 1.0 1.2 1.6 -1.3 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.2 -0.1 1.1
Whole body fat mass 0.3 1.2 1.3 -1.1 -1.0
Leg fat mass (right) 0.0 0.1 0.2 -0.1 -0.5
Arm predicted mass (right) 3.8 19.3 36.5 -6.0 -1.4
Pulse rate, automated reading 0.0 0.1 0.2 -0.5 -0.2
Alcohol intake frequency. 1.8 4.3 7.2 -2.7 1.2
Comparative height size at age 10 7.7 42.6 82.6 -9.1 -1.6
Number of full sisters 0.4 0.5 0.7 0.9 0.6
Suffer from ‘nerves’ 2.6 4.0 6.0 -2.4 1.4
Overall health rating 0.9 1.9 3.5 -1.9 0.5
Chest pain or discomfort 0.6 0.9 1.3 0.7 -1.1
Had major operations 0.1 0.1 0.1 -0.3 0.4
Age at last live birth 0.3 0.5 0.9 -0.1 -0.9
Family relationship satisfaction 3.4 4.1 8.1 -2.8 0.4
Leg pain on walking 0.2 0.2 0.3 -0.4 -0.5
Qualifications: NVQ or HND or HNC or equivalent 1.6 1.9 3.0 0.9 1.7
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.5 0.7 -0.4
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 1.5 -0.7 1.2
Medication: Aspirin 0.3 0.5 0.9 -0.9 0.1
Supplements: Vitamin C 0.3 0.4 0.4 -0.6 -0.6
Knee pain experienced in last month 0.7 1.1 1.2 -1.1 -1.0
Hypertension (Self-reported) 2.5 7.0 13.5 -3.7 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.2 2.2 -1.5 -0.6
Illnesses of father: Heart disease 0.1 0.2 0.4 0.6 -0.2
Illnesses of siblings: Diabetes 4.7 5.8 9.5 -1.4 3.1
Smoking status: Previous 0.1 0.1 0.2 0.4 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 6.9 14.4 17.7 -4.2 -3.3
Whole body fat-free mass 3.9 22.6 41.6 -6.5 -1.9
Leg fat-free mass (right) 2.4 12.7 22.8 -4.8 -1.6
Arm fat percentage (left) 0.6 2.5 4.8 2.2 -0.5
Average weekly red wine intake 1.7 2.5 4.7 -0.5 -2.2
Handedness (chirality/laterality): Left-handed 0.5 0.6 0.7 0.8 0.6
Mood swings 1.4 2.5 4.8 0.5 -2.2
Loneliness, isolation 0.4 0.5 0.7 0.9 0.5
Long-standing illness, disability or infirmity 0.6 1.0 1.5 -1.2 0.6
Ever had bowel cancer screening 1.7 2.0 3.3 -1.8 0.8
Diabetes diagnosed by doctor 5.5 9.0 12.8 -2.3 3.6
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 1.9 -1.4 0.1
Friendships satisfaction 1.5 1.8 3.0 -1.7 0.8
Qualifications: nursing, teaching 0.7 1.0 1.2 -1.1 -0.9
Commuting to job workplace: Walk 0.2 0.2 0.3 0.4 0.6
Eye problems/disorders: Cataract 0.7 0.8 1.1 -0.7 1.1
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.4 -0.4 -0.7
Medication for cholesterol 0.2 0.4 0.6 0.8 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.9 3.4 3.6 -1.8 1.9
Back pain experienced in last month 0.8 1.1 2.1 -0.4 -1.4
Mineral and other dietary supplements 0.8 1.1 1.3 1.2 0.9
Breast cancer (self-reported) 0.3 0.3 0.6 -0.8 -0.2
Asthma (self-reported) 0.5 0.9 1.3 -0.7 1.1
Osteoporosis (self-reported) 1.8 2.2 4.4 -2.1 -0.2
Osteoarthritis (self-reported) 1.3 1.7 3.4 0.1 -1.8
Medication: Aspirin 0.2 0.2 0.5 -0.7 0.1
Medication: Gliclazide 0.7 0.8 1.5 -1.2 0.4
Illnesses of father: None of the above (group 1) 0.9 1.1 1.5 -0.8 1.2
Smoking status: Current 0.8 1.2 1.8 1.3 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.9 -0.1 -0.9
Whole body water mass 4.0 22.8 41.9 -6.5 -1.9
Leg predicted mass (right) 2.4 12.7 22.6 -4.8 -1.7
Arm fat mass (left) 0.1 0.3 0.6 -0.2 -0.7
Number of self-reported non-cancer illnesses 0.9 1.6 2.9 -1.7 0.5
Average weekly champagne plus white wine intake 2.9 4.0 7.9 0.2 -2.8
Miserableness 0.4 0.8 1.3 1.1 -0.5
Guilty feelings 0.9 1.4 1.8 -1.3 -1.0
Wears glasses or contact lenses 1.7 1.9 2.2 -1.5 1.3
Ever taken oral contraceptive pill 0.0 0.0 0.1 -0.0 -0.3
Hearing aid user 0.3 0.3 0.6 0.8 0.1
Mother’s age at death 0.0 0.0 0.0 0.1 0.1
Financial situation satisfaction 0.6 0.7 1.2 0.5 1.1
Tinnitus: Yes, now most or all of the time 0.4 0.5 0.9 0.1 -1.0
Commuting to job workplace: Public transport 1.9 2.2 4.2 -2.1 0.5
Eye problems/disorders: Glaucoma 0.2 0.2 0.3 -0.6 -0.1
Medication: Blood pressure 0.3 0.5 1.0 -1.0 0.2
Pain type(s) experienced in last month: Hip pain 0.0 0.0 0.0 -0.1 -0.0
Supplements: Fish oil (including cod liver oil) 1.0 1.3 1.5 -1.1 1.2
High cholesterol (Self-reported) 0.9 1.7 2.2 -1.5 1.0
Medication: Bendroflumethiazide 3.2 4.8 8.8 -3.0 0.9
Medication: Paracetamol 1.9 2.9 3.4 -1.9 -1.5
Medication: Lisinopril 1.8 2.4 3.9 -0.9 2.0
Medication: Atorvastatin 0.3 0.3 0.6 0.8 0.2
Illnesses of father: High blood pressure 1.1 1.3 1.8 -1.3 -0.9
Alcohol drinker status: Never 2.9 3.4 6.4 -2.5 0.7
Ever smoked 0.5 0.9 1.5 1.2 -0.6
Basal metabolic rate 3.4 18.8 33.4 -5.8 -2.1
Leg fat percentage (left) 0.5 1.9 3.8 2.0 -0.2
Arm fat-free mass (left) 3.9 19.6 37.1 -6.1 -1.4
Number of operations (self-reported) 2.5 3.7 6.7 -2.6 -0.9
Average weekly beer plus cider intake 0.0 0.0 0.1 0.2 -0.1
Irritability 0.7 1.1 2.1 -0.4 -1.5
Risk taking 2.1 3.0 5.2 2.3 -0.9
Ever had prostate specific antigen (PSA) test 2.7 3.1 5.2 2.3 -1.0
Fractured/broken bones in last 5 years 1.1 1.4 2.2 -0.7 -1.5
Age started oral contraceptive pill 0.8 1.0 1.9 0.4 1.4
Diastolic blood pressure, automated reading 1.1 3.5 6.8 -2.6 0.5
Ever depressed for a whole week 0.2 0.3 0.4 -0.6 0.4
Unable to work because of sickness or disability 0.2 0.2 0.3 -0.5 0.3
Commuting to job workplace: Cycle 0.3 0.4 0.5 0.5 -0.7
Myopia 1.2 1.8 3.4 0.3 1.9
Vascular/heart problems diagnosed by doctor 1.6 4.4 8.2 2.9 -0.8
Cholesterol lowering medication 1.7 2.5 4.4 -2.1 0.8
Medication: Omeprazole (e.g. Zanprol) 3.0 3.7 4.7 -2.2 1.6
Pain experienced in last month 0.8 1.3 1.3 1.1 1.1
Supplements: Calcium 1.6 1.8 2.6 -1.0 -1.6
Basal cell carcinoma (self-reported) 0.5 0.6 0.8 0.9 -0.7
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.3 0.6 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.1 -0.3 -0.2
Heart disease (siblings) 0.3 0.4 0.6 0.5 0.7
Alcohol drinker status: Previous 0.2 0.2 0.3 0.5 0.3
Pack years of smoking 0.2 0.3 0.5 -0.7 -0.0
Impedance of whole body 0.4 1.9 3.5 0.5 -1.9
Leg fat mass (left) 0.0 0.1 0.2 0.1 -0.5
Arm predicted mass (left) 4.3 21.7 40.3 -6.3 -1.7