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chr3:55,894,951-59,191,320

Best TWAS P=3.35e-26 · Best GWAS P=2.79e-45 conditioned to 7.49e-13

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Adipose Subcutaneous	FAM208A	0.12	0.09	enet	11	0.12	1.1e-09	-11.9	10.6	4.6e-26	-0.74	0.57	0.43	TRUE
5	GTEx	Adipose Subcutaneous	PXK	0.09	0.05	lasso	4	0.04	2.1e-04	-9.6	10.1	8.0e-24	0.01	0.02	0.98	TRUE
57	NTR	Blood	ARHGEF3	0.04	0.01	enet	21	0.01	9.1e-06	3.5	7.8	8.7e-15	-0.58	0.23	0.74	TRUE
54	METSIM	Adipose	APPL1	0.04	0.00	blup	416	0.02	2.1e-04	2.7	-5.4	5.7e-08	0.20	0.08	0.04	TRUE
70	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C3orf63	0.03	0.01	enet	4	0.01	1.3e-02	-8.6	10.6	3.4e-26	-0.72	0.03	0.66	FALSE
13	GTEx	Brain Cerebellum	CCDC66	0.27	0.13	enet	14	0.18	6.3e-06	-7.9	10.3	6.0e-25	-0.66	0.06	0.91	FALSE
42	GTEx	Skin Sun Exposed Lower leg	FAM208A	0.06	0.04	lasso	2	0.03	2.0e-03	-10.0	10.0	1.8e-23	-0.70	0.13	0.66	FALSE
27	GTEx	Cells Transformed fibroblasts	PXK	0.12	0.13	lasso	9	0.12	2.6e-09	-9.6	-9.7	2.8e-22	-0.02	0.02	0.98	FALSE
62	ROSMAP	Brain Pre-frontal Cortex	PXK	0.24	0.27	enet	38	0.30	1.1e-39	-9.8	9.6	6.2e-22	0.03	0.02	0.98	FALSE
49	GTEx	Thyroid	PXK	0.11	0.09	lasso	7	0.07	9.4e-06	-9.6	9.6	6.6e-22	0.02	0.02	0.98	FALSE
53	GTEx	Whole Blood	PXK	0.06	0.06	lasso	1	0.06	2.3e-06	-9.6	9.6	1.1e-21	0.02	0.02	0.98	FALSE
17	GTEx	Brain Hippocampus	CCDC66	0.23	0.23	lasso	3	0.20	2.1e-05	-9.2	9.4	3.2e-21	-0.69	0.18	0.40	FALSE
48	GTEx	Stomach	RP11-802O23.3	0.12	0.01	enet	19	0.02	5.2e-02	-9.8	-9.4	4.9e-21	-0.02	0.02	0.97	FALSE
29	GTEx	Esophagus Muscularis	PXK	0.10	0.05	lasso	4	0.05	3.8e-04	-9.8	9.4	5.3e-21	0.04	0.02	0.96	FALSE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	PDHB	0.11	0.15	lasso	7	0.15	1.3e-15	-9.6	-9.2	2.2e-20	-0.01	0.01	0.99	FALSE
16	GTEx	Brain Frontal Cortex BA9	CCDC66	0.16	0.18	lasso	3	0.14	1.3e-04	-7.9	9.2	2.7e-20	-0.68	0.03	0.89	FALSE
46	GTEx	Stomach	PDHB	0.13	0.05	enet	17	0.05	2.1e-03	-9.8	-9.2	2.7e-20	-0.03	0.02	0.98	FALSE
41	GTEx	Pituitary	CCDC66	0.16	0.16	enet	31	0.12	6.8e-04	-7.9	9.1	7.4e-20	-0.62	0.12	0.56	FALSE
85	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RPP14	0.10	0.06	lasso	8	0.08	1.2e-03	-8.6	-9.1	1.3e-19	0.02	0.02	0.36	FALSE
11	GTEx	Brain Caudate basal ganglia	CCDC66	0.18	0.16	lasso	5	0.16	3.3e-05	-7.9	8.9	3.5e-19	-0.64	0.19	0.40	FALSE
86	The Cancer Genome Atlas	Thyroid Carcinoma	ABHD6	0.15	0.17	lasso	4	0.16	1.4e-15	-8.8	8.9	3.8e-19	-0.02	0.00	1.00	FALSE
89	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ABHD6	0.18	0.13	lasso	3	0.13	1.8e-04	-8.9	8.9	4.5e-19	-0.01	0.01	0.93	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDHB	0.04	0.05	enet	7	0.06	8.3e-13	-9.8	-8.9	8.3e-19	-0.01	0.01	0.99	FALSE
26	GTEx	Cells Transformed fibroblasts	FAM208A	0.10	0.00	lasso	4	0.00	1.3e-01	-8.5	8.8	1.1e-18	-0.64	0.20	0.45	FALSE
50	GTEx	Thyroid	CCDC66	0.22	0.26	lasso	4	0.26	5.9e-20	-7.9	8.7	2.3e-18	-0.63	1.00	0.00	FALSE
61	NTR	Blood	RPP14	0.01	0.01	lasso	1	0.01	2.2e-03	-8.6	-8.7	5.3e-18	0.03	0.06	0.92	FALSE
66	YFS	Blood	ARHGEF3	0.13	0.04	bslmm	536	0.07	1.5e-20	-5.1	8.4	5.7e-17	-0.72	0.09	0.91	FALSE
18	GTEx	Brain Hypothalamus	CCDC66	0.18	0.26	lasso	3	0.22	5.6e-06	-7.9	8.1	6.2e-16	-0.59	0.12	0.34	FALSE
21	GTEx	Breast Mammary Tissue	CCDC66	0.19	0.21	lasso	3	0.19	5.7e-10	-7.9	8.0	1.0e-15	-0.60	0.93	0.07	FALSE
47	GTEx	Stomach	CCDC66	0.16	0.06	lasso	4	0.06	8.5e-04	-7.9	8.0	1.2e-15	-0.60	0.18	0.06	FALSE
75	The Cancer Genome Atlas	Brain Lower Grade Glioma	ABHD6	0.09	0.04	enet	8	0.04	5.1e-05	-8.7	-8.0	1.2e-15	0.02	0.01	0.99	FALSE
19	GTEx	Brain Putamen basal ganglia	CCDC66	0.36	0.28	lasso	3	0.25	1.3e-06	-7.9	8.0	1.3e-15	-0.58	0.10	0.44	FALSE
78	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PDHB	0.06	0.01	blup	40	0.04	1.8e-03	3.4	-8.0	1.5e-15	-0.02	0.02	0.83	FALSE
34	GTEx	Lung	CCDC66	0.13	0.15	lasso	2	0.15	1.4e-11	-7.9	8.0	1.9e-15	-0.59	1.00	0.00	FALSE
14	GTEx	Brain Cortex	CCDC66	0.18	0.24	lasso	1	0.20	3.8e-06	-7.9	7.9	2.0e-15	-0.59	0.07	0.76	FALSE
39	GTEx	Pancreas	CCDC66	0.19	0.16	lasso	3	0.15	9.1e-07	-7.9	7.9	2.0e-15	-0.59	0.45	0.04	FALSE
73	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ABHD6	0.09	0.07	lasso	3	0.03	4.3e-03	6.8	7.9	2.3e-15	0.01	0.18	0.46	FALSE
59	NTR	Blood	PDHB	0.02	0.01	bslmm	434	0.01	1.1e-03	-9.8	-7.9	2.5e-15	-0.01	0.02	0.98	FALSE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ABHD6	0.05	0.00	enet	15	0.02	1.1e-03	-8.7	7.8	4.6e-15	0.04	0.01	0.88	FALSE
7	GTEx	Artery Aorta	CCDC66	0.21	0.22	lasso	3	0.20	4.1e-11	-7.9	7.8	7.1e-15	-0.58	1.00	0.00	FALSE
23	GTEx	Breast Mammary Tissue (Female)	CCDC66	0.16	0.06	enet	10	0.14	4.3e-05	-7.9	7.7	1.1e-14	-0.58	0.11	0.36	FALSE
79	The Cancer Genome Atlas	Prostate Adenocarcinoma	ABHD6	0.10	0.09	lasso	3	0.07	5.3e-08	-7.6	7.7	1.9e-14	0.01	0.94	0.06	FALSE
35	GTEx	Muscle Skeletal	PXK	0.07	0.04	lasso	6	0.03	6.0e-04	6.9	7.6	2.2e-14	-0.01	0.08	0.90	FALSE
45	GTEx	Spleen	CCDC66	0.31	0.22	lasso	10	0.20	1.0e-05	-7.9	7.6	2.9e-14	-0.56	0.17	0.05	FALSE
43	GTEx	Skin Sun Exposed Lower leg	CCDC66	0.09	0.09	lasso	5	0.05	8.1e-05	-7.9	7.6	4.2e-14	-0.57	0.94	0.00	FALSE
44	GTEx	Spleen	PXK	0.33	0.13	lasso	18	0.18	2.2e-05	5.3	7.5	4.3e-14	-0.01	0.03	0.93	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	KCTD6	0.05	0.03	enet	11	0.04	2.5e-06	-9.6	7.5	4.3e-14	-0.01	0.02	0.98	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	PDHB	0.07	0.09	lasso	3	0.09	2.7e-09	5.3	-7.5	6.3e-14	-0.01	0.10	0.90	FALSE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PXK	0.05	0.03	enet	9	0.05	1.3e-06	4.9	7.5	8.0e-14	-0.01	0.49	0.46	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	CCDC66	0.24	0.24	lasso	6	0.25	1.0e-31	-7.9	7.4	1.0e-13	-0.56	1.00	0.00	FALSE
71	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDHB	0.05	0.03	enet	10	0.06	4.3e-07	4.2	-7.4	1.3e-13	0.01	0.32	0.67	FALSE
8	GTEx	Artery Tibial	ABHD6	0.10	0.05	lasso	4	0.08	1.0e-06	-8.8	-7.4	1.8e-13	0.01	0.47	0.50	FALSE
65	YFS	Blood	ABHD6	0.02	0.02	lasso	4	0.02	8.4e-07	7.1	7.3	2.2e-13	0.02	0.67	0.31	FALSE
31	GTEx	Heart Atrial Appendage	ACOX2	0.13	0.00	enet	11	0.02	5.9e-02	-3.1	7.3	3.1e-13	0.02	0.05	0.65	FALSE
58	NTR	Blood	C3orf63	0.02	0.01	enet	17	0.02	2.0e-06	-10.2	-7.2	4.8e-13	0.57	0.54	0.41	FALSE
37	GTEx	Nerve Tibial	CCDC66	0.30	0.27	lasso	4	0.27	2.1e-19	-7.9	7.1	9.2e-13	-0.54	1.00	0.00	FALSE
33	GTEx	Heart Left Ventricle	CCDC66	0.18	0.17	lasso	3	0.18	5.2e-10	-7.9	7.1	1.4e-12	-0.52	0.96	0.01	FALSE
10	GTEx	Artery Tibial	PXK	0.14	0.07	enet	22	0.10	2.1e-08	6.9	7.1	1.7e-12	0.00	0.17	0.83	FALSE
30	GTEx	Esophagus Muscularis	CCDC66	0.27	0.25	lasso	6	0.26	8.0e-16	-7.9	7.0	2.8e-12	-0.52	1.00	0.00	FALSE
51	GTEx	Thyroid	RP11-802O23.3	0.06	0.05	lasso	4	0.04	9.9e-04	6.8	7.0	3.1e-12	0.01	0.46	0.12	FALSE
38	GTEx	Ovary	CCDC66	0.47	0.22	lasso	7	0.14	2.5e-04	-7.9	7.0	3.5e-12	-0.51	0.07	0.22	FALSE
6	GTEx	Adipose Visceral Omentum	PXK	0.18	0.12	lasso	1	0.05	1.3e-03	6.9	6.9	5.4e-12	-0.03	0.45	0.46	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	PXK	0.15	0.13	lasso	1	0.04	2.1e-02	6.9	6.9	5.4e-12	-0.03	0.06	0.57	FALSE
28	GTEx	Esophagus Mucosa	CCDC66	0.23	0.14	lasso	3	0.17	2.9e-11	-7.9	6.9	6.0e-12	-0.54	0.99	0.00	FALSE
76	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PDHB	0.05	0.05	lasso	2	0.04	3.7e-03	4.4	-6.7	1.6e-11	0.00	0.02	0.74	FALSE
83	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PDHB	0.25	0.27	lasso	11	0.29	1.1e-10	4.4	-6.7	1.9e-11	0.01	0.09	0.91	FALSE
77	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PDHB	0.05	0.03	blup	40	0.05	1.2e-06	4.2	-6.6	4.5e-11	0.01	0.68	0.29	FALSE
40	GTEx	Pituitary	PXK	0.31	0.11	lasso	7	0.09	2.8e-03	3.4	6.6	4.7e-11	0.01	0.06	0.85	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PXK	0.12	0.00	bslmm	473	0.03	1.9e-04	6.8	6.5	1.1e-10	0.08	0.06	0.81	FALSE
88	The Cancer Genome Atlas	Thyroid Carcinoma	PXK	0.12	0.10	enet	14	0.10	3.5e-10	5.1	6.5	1.1e-10	-0.02	1.00	0.00	FALSE
20	GTEx	Breast Mammary Tissue	PXK	0.16	0.05	enet	18	0.06	6.7e-04	5.3	6.4	1.5e-10	-0.01	0.24	0.52	FALSE
84	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PXK	0.09	0.05	enet	23	0.08	7.4e-04	3.3	6.4	2.0e-10	0.01	0.05	0.30	FALSE
56	METSIM	Adipose	PXK	0.04	0.02	lasso	14	0.03	8.9e-05	4.6	6.3	3.0e-10	-0.02	0.14	0.84	FALSE
15	GTEx	Brain Cortex	RP11-802O23.3	0.34	0.06	lasso	7	0.05	1.8e-02	6.8	6.3	3.1e-10	0.02	0.09	0.17	FALSE
12	GTEx	Brain Cerebellar Hemisphere	PDHB	0.21	0.13	lasso	4	0.07	7.6e-03	6.8	6.3	3.7e-10	0.02	0.20	0.15	FALSE
82	The Cancer Genome Atlas	Rectum Adenocarcinoma	RPP14	0.18	0.12	enet	27	0.14	4.6e-04	-8.7	-6.2	4.0e-10	0.03	0.04	0.49	FALSE
32	GTEx	Heart Atrial Appendage	CCDC66	0.29	0.20	enet	29	0.20	2.4e-09	-7.9	6.2	6.7e-10	-0.43	0.89	0.05	FALSE
80	The Cancer Genome Atlas	Prostate Adenocarcinoma	FLNB	0.04	0.03	enet	6	0.03	3.0e-04	-5.7	6.2	7.6e-10	-0.02	0.01	0.98	FALSE
67	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PDHB	0.05	0.03	blup	40	0.06	1.4e-05	4.2	-6.1	9.8e-10	0.00	0.09	0.83	FALSE
60	NTR	Blood	PXK	0.04	0.03	enet	13	0.04	8.5e-13	4.4	6.0	2.6e-09	0.01	0.87	0.13	FALSE
74	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PDHB	0.10	0.01	enet	12	0.04	3.2e-03	7.0	-5.8	5.6e-09	-0.04	0.01	0.86	FALSE
22	GTEx	Breast Mammary Tissue (Male)	CCDC66	0.05	0.03	lasso	3	0.04	5.1e-02	-7.9	5.8	6.2e-09	-0.49	0.05	0.07	FALSE
9	GTEx	Artery Tibial	PDHB	0.12	0.11	lasso	6	0.11	7.4e-09	3.4	-5.7	1.4e-08	-0.01	0.16	0.84	FALSE
36	GTEx	Nerve Tibial	PXK	0.47	0.27	enet	34	0.30	1.7e-21	4.4	5.6	2.2e-08	0.01	1.00	0.00	FALSE
52	GTEx	Vagina	ARHGEF3	0.33	0.06	enet	19	0.12	9.8e-04	-5.8	-5.5	4.2e-08	0.26	0.10	0.21	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	PDHB	0.21	0.10	enet	9	0.06	5.1e-03	5.0	5.4	5.9e-08	0.00	0.14	0.04	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CCDC66	0.25	0.12	lasso	9	0.19	1.8e-22	-7.9	5.3	9.7e-08	-0.38	1.00	0.00	FALSE
55	METSIM	Adipose	PDHB	0.13	0.07	bslmm	434	0.09	1.4e-13	4.2	-5.2	1.6e-07	-0.01	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	KCTD6	0.05	0.02	lasso	9	0.01	8.1e-03	4.1	5.2	2.1e-07	0.02	0.19	0.52	FALSE