Hub : Genes

RPP14

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0840	0.0270	9.9e-07	0.053	0.058	0.068	0.059	0.077	4.2e-07	1.3e-07	1.2e-08	1.1e-07	1.3e-09
2	GTEx	Colon Transverse	0.2040	0.0700	7.1e-04	0.109	NA	0.062	NA	0.120	7.3e-06	NA	6.6e-04	NA	2.6e-06
3	GTEx	Heart Atrial Appendage	0.3780	0.0790	9.3e-09	0.244	NA	0.207	NA	0.217	2.6e-11	NA	1.1e-09	NA	4.0e-10
4	GTEx	Heart Left Ventricle	0.2330	0.0566	1.7e-07	0.233	NA	0.241	NA	0.225	1.1e-12	NA	4.6e-13	NA	3.4e-12
5	GTEx	Muscle Skeletal	0.2579	0.0509	9.4e-15	0.173	NA	0.190	NA	0.191	1.0e-16	NA	2.6e-18	NA	2.0e-18
6	GTEx	Stomach	0.1340	0.0580	6.9e-03	0.056	NA	0.009	NA	0.040	1.1e-03	NA	1.1e-01	NA	5.5e-03
7	NTR	Blood	0.0140	0.0062	3.7e-03	0.010	0.004	0.003	0.003	0.007	2.1e-04	1.4e-02	3.1e-02	2.2e-02	2.1e-03
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0892	0.0429	1.2e-05	0.047	0.052	0.039	NA	0.043	4.8e-06	1.7e-06	2.9e-05	NA	1.3e-05
9	TCGA	Kidney Renal Papillary Cell Carcinoma	0.7720	0.1180	2.9e-09	0.062	0.148	0.173	NA	0.158	2.0e-04	7.9e-09	3.6e-10	NA	2.4e-09
10	TCGA	Brain Lower Grade Glioma	0.1226	0.0705	1.8e-07	0.022	0.063	0.057	NA	0.056	1.2e-03	1.2e-07	4.4e-07	NA	6.0e-07
11	TCGA	Prostate Adenocarcinoma	0.0369	0.0219	1.9e-03	0.031	0.022	0.016	NA	0.022	3.4e-04	2.2e-03	7.3e-03	NA	1.9e-03
12	TCGA	Rectum Adenocarcinoma	0.1840	0.1000	3.8e-03	0.121	0.051	0.135	NA	0.097	9.3e-04	2.5e-02	4.6e-04	NA	2.8e-03
13	TCGA	Testicular Germ Cell Tumors	0.1030	0.0620	7.5e-03	0.064	0.069	0.063	NA	0.076	2.7e-03	2.0e-03	2.9e-03	NA	1.2e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	1.0	1.6	9.7	2.0	0.5	0.7	-0.1	0.9	1.1	-1.5	-0.5	-0.3	-0.2	-3.1	0.4	-1.1
Bipolar Disorder or Schizophrenia	1.3	3.1	9.9	1.4	-0.8	-0.1	-0.8	0.3	-0.5	-2.8	-2.1	-2.0	-1.9	-3.2	-0.8	-2.5
Depressed Affect (Nagel 2018)	1.4	2.9	6.8	-2.6	-2.3	-2.1	-1.1	-2.1	-2.3	0.2	-1.6	-1.7	-1.4	1.7	0.3	0.4
Depression (Nagel 2018)	0.2	0.3	1.3	0.1	-0.1	-0.1	0.0	-0.2	-0.5	-1.0	-0.4	0.4	-0.4	0.1	-1.0	-1.1
Intelligence (Savage-Jansen 2018)	0.2	0.8	1.7	1.3	0.9	1.0	1.2	1.2	0.6	-0.3	0.6	0.9	0.9	-0.7	0.5	-0.2
Neuroticism (Nagel 2018)	1.5	3.5	9.0	-3.0	-2.5	-2.1	-1.2	-2.0	-2.9	-0.1	-1.7	-1.7	-1.5	2.0	0.4	0.2
Schizophrenia (2018)	1.3	2.8	5.7	0.2	-1.3	-0.6	-0.9	-0.3	-1.5	-2.4	-2.2	-2.3	-2.2	-1.5	-1.4	-2.3
Schizophrenia vs Biploar Disorder	0.7	1.0	3.4	-1.0	-1.0	-0.6	-0.3	-0.9	-1.9	-0.7	-1.1	-1.0	-1.1	0.9	-0.7	-0.9
Worry (Nagel 2018)	4.6	9.8	17.5	-3.7	-3.9	-3.5	-3.2	-3.5	-4.2	-1.8	-3.4	-3.3	-3.5	1.7	-1.8	-1.6
Alzheimer’s Disease (in mother)	0.8	1.0	2.3	-0.4	0.7	0.9	0.5	0.8	0.4	1.4	1.3	1.5	0.9	1.1	0.9	1.2
Alzheimer’s Disease (in father)	0.3	0.3	0.7	-0.1	-0.5	-0.5	-0.6	-0.1	-0.4	-0.7	-0.6	-0.5	-0.8	-0.1	-0.1	-0.9
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	-0.4	0.2	0.6	0.3	0.6	-0.2	0.6	0.6	0.9	0.1	0.6	0.8	0.2
Crohns Disease (2017)	0.4	0.9	4.3	1.5	0.6	1.3	0.5	1.3	0.5	-0.8	-0.3	-0.4	0.1	-2.1	0.3	-0.6
Irritable Bowel Disease (IBD)	0.5	1.3	6.2	1.6	0.6	1.2	0.5	1.5	0.2	-1.0	-0.5	-0.6	0.0	-2.5	1.2	-0.6
Ulcerative Colitis (UC)	0.4	0.8	3.5	1.3	0.5	0.7	0.4	1.2	0.2	-0.9	-0.3	-0.3	0.2	-1.9	1.0	-0.5
Major Depression (MDD)	0.5	0.6	1.8	-0.4	0.4	0.3	0.6	0.1	-1.2	0.2	1.0	1.0	0.8	1.4	0.5	0.1
Reaction Time	1.9	3.7	17.2	1.2	1.6	1.3	1.0	1.2	4.2	0.9	2.1	3.1	2.4	0.7	-0.2	1.0
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.9	1.7	1.4	1.6	1.2	1.4	0.9	-0.7	0.7	0.9	0.6	-1.1	-0.7	-0.7
Breast Cancer	1.2	2.9	5.2	2.2	2.0	1.9	1.6	2.1	2.3	0.6	1.6	1.7	1.9	-1.0	1.2	0.7
Ovarian Cancer	2.0	2.6	4.6	1.3	1.9	1.3	2.0	1.4	2.0	1.3	1.9	1.8	2.2	0.1	1.2	1.4
Prostate Cancer	0.7	1.0	3.6	-1.2	-1.1	-1.9	-1.4	-1.2	0.4	0.4	-0.8	-1.0	-0.7	0.3	-0.0	0.5
Age at First Birth	0.3	0.5	1.6	0.7	0.3	-0.1	-0.2	0.3	0.3	-1.2	-0.2	-0.3	-0.5	-0.7	-1.2	-1.3
Bipolar Disorder (2011)	0.3	0.3	2.0	0.5	-0.1	0.1	-0.3	0.5	0.8	-0.2	-0.3	-0.1	-0.1	-1.4	0.9	0.1
Body Mass Index (BMI) (2010)	1.2	1.7	6.3	-1.0	-0.1	0.2	0.2	0.0	0.7	2.2	0.9	1.0	1.5	1.1	2.1	2.5
Coronary Artery Disease (CAD)	0.4	0.4	1.8	-1.4	-0.2	0.2	-0.5	-0.5	-0.3	0.6	0.2	0.5	0.0	0.8	1.2	0.8
Crohns Disease (2012)	0.4	0.6	3.0	1.3	0.4	0.4	-0.8	0.4	1.1	-0.7	-0.4	-0.6	0.2	-1.7	0.2	-0.4
Mean Putamen Volume	2.9	3.3	6.8	-1.0	-1.7	-2.0	-1.9	-1.9	-2.6	-2.3	-1.4	-1.0	-1.0	1.8	-1.9	-2.1
Fasting Glucose	1.7	2.0	6.2	1.2	-0.1	0.2	-0.9	-0.3	-0.5	-2.5	-1.4	-1.6	-1.1	-1.8	-1.8	-2.1
HbA1C	3.4	3.8	10.2	1.3	2.1	1.1	2.2	1.7	2.6	0.8	2.0	2.5	2.1	-0.8	3.2	1.3
HDL Cholesterol	0.5	0.9	3.8	-1.2	-0.6	0.0	0.1	-0.3	-0.3	1.5	-0.1	-0.4	0.1	0.7	1.9	1.6
LDL Cholesterol	0.7	1.1	6.0	0.5	-0.1	0.1	-0.3	0.4	0.4	0.2	-1.1	-1.2	-1.3	-2.4	1.6	0.2
Lupus	4.6	7.0	16.2	-0.6	-1.6	-2.5	-2.1	-2.4	-3.5	-3.6	-1.9	-1.5	-2.7	0.8	-3.9	-4.0
Neuroticism (2016)	0.5	0.7	3.5	-1.0	-1.0	-0.3	0.1	-0.5	-1.9	0.2	-0.6	-1.7	-0.3	0.3	-0.3	0.5
Primary Biliary Cirrhosis	1.6	2.2	6.6	1.3	0.1	-0.1	-1.0	0.1	-0.7	-2.0	-1.5	-1.4	-2.1	-2.5	-0.5	-2.6
Rheumatoid Arthritis	1.6	2.1	6.2	-2.5	-1.5	-1.6	-1.0	-1.8	-1.6	1.5	-0.5	-0.9	-0.6	1.8	1.1	1.3
Schizophrenia (2014)	1.7	3.8	7.3	0.4	-1.4	-0.8	-1.2	-0.5	-1.6	-2.6	-2.5	-2.7	-2.7	-2.2	-1.8	-2.6
Triglycerides	0.3	0.5	1.7	1.2	0.5	0.6	-0.3	0.6	0.8	-0.9	-0.0	0.5	-0.0	-1.3	-0.6	-0.8
Type 2 Diabetes (T2D) (2012)	1.5	1.7	7.5	0.8	-0.5	-0.3	-1.0	0.1	-0.1	-1.6	-1.6	-0.9	-1.9	-2.7	0.3	-1.7
Ulcerative Colitis	0.9	1.4	3.7	0.9	-0.4	-0.2	-0.9	-0.1	-0.8	-1.8	-1.5	-1.4	-1.2	-1.9	-0.0	-1.6
Blood Eosinophil Count	0.4	2.9	9.5	1.4	0.3	0.5	-0.7	-0.2	-0.7	-2.3	-1.3	-1.3	-2.5	-2.3	-2.1	-3.1
Blood Platelet Count	7.3	84.9	275.6	-16.6	-10.1	-9.2	-6.6	-10.4	-11.2	7.7	-3.8	-6.3	-3.9	12.9	2.8	7.8
Blood Red Count	2.4	22.8	82.1	2.9	-1.2	-1.9	-3.4	-1.9	-4.2	-8.7	-4.0	-2.9	-4.6	-3.0	-6.2	-9.1
Blood White Count	0.1	0.8	3.0	-0.9	-0.4	0.7	-0.1	-0.4	-1.5	1.2	0.1	-0.7	0.1	0.6	1.7	1.2
Heel T-Score	0.8	6.5	22.2	-2.5	-3.1	-4.7	-3.0	-4.1	-0.6	-1.4	-2.0	-1.0	-0.5	3.1	-2.1	-0.6
BMI	0.4	2.3	9.0	-1.8	-0.7	-0.1	0.3	-0.2	1.2	2.6	0.5	0.7	1.0	0.9	2.6	3.0
Height	0.7	13.4	45.8	6.1	2.3	3.0	2.2	2.3	-0.1	-5.2	-1.4	-1.9	-1.6	-6.8	-1.8	-5.2
Waist Hip Ratio (WHR)	1.2	5.3	13.8	-0.9	-1.8	-2.1	-3.4	-2.2	-1.7	-1.6	-2.6	-2.5	-3.7	-1.5	-2.0	-2.2
Systolic Blood Pressure	0.7	3.4	12.0	-1.2	0.6	0.3	0.8	0.3	1.3	3.3	2.0	0.9	2.0	1.6	2.3	3.5
Smoking Status	0.6	1.3	3.6	-1.7	-1.1	-1.1	-0.8	-1.3	-1.9	0.5	-0.9	-1.4	-1.5	0.8	-0.3	0.1
Allergy or Eczema	0.1	0.4	1.3	-0.7	-0.7	-0.4	0.1	-0.8	-1.1	0.2	-0.6	-1.0	-0.7	-0.0	0.1	0.2
Cardiovascular Disease	0.7	2.3	5.8	-2.4	-2.0	-1.9	-1.7	-1.9	-0.6	1.0	-1.3	-1.1	-1.3	0.8	1.7	1.0
Hypothyroidism (self reported)	4.4	10.2	17.1	-1.7	-2.8	-4.1	-2.9	-3.3	-3.7	-3.2	-3.3	-3.1	-4.0	0.2	-3.3	-3.7
Respiratory disease	0.2	0.4	1.8	0.6	0.1	1.4	0.8	1.1	0.1	-0.0	0.0	0.1	0.6	-0.5	0.9	0.2
Type 2 Diabetes (T2D) (2018)	1.2	2.3	7.3	1.5	0.1	0.0	-0.5	-0.4	-0.7	-2.3	-1.4	-0.9	-2.0	-2.6	-0.5	-2.7
Lung FEV1/FVC ratio	0.4	2.3	9.9	-0.7	-1.4	-2.3	-3.1	-1.0	1.5	-0.1	-1.7	-1.0	-1.4	-1.6	0.5	0.2
Lung FVC	0.4	1.9	7.7	-1.1	-0.2	-0.9	-0.4	-0.7	0.7	1.5	1.2	1.3	2.1	2.8	0.5	1.9
Neuroticism	1.5	3.6	7.3	-2.4	-2.4	-2.0	-1.6	-2.2	-2.7	-0.8	-2.2	-2.4	-2.0	1.0	-0.5	-0.6
Chronotype (morning person)	1.0	2.4	6.4	2.5	1.6	1.8	1.2	2.1	2.2	-0.6	0.6	1.1	0.8	-2.3	-0.0	-0.6
Hair Pigment	0.0	1.0	3.5	-0.0	-0.2	-0.4	-0.9	-0.5	-1.0	-1.2	-0.6	0.5	-1.5	-0.8	-1.6	-1.9
Tanning	0.1	0.7	2.3	-0.3	0.1	-0.1	0.7	0.0	0.5	0.8	0.7	0.6	1.5	1.4	0.7	1.2
Hand grip strength (left)	0.5	1.2	3.4	-0.7	-0.6	-1.0	-1.5	-1.2	-1.0	-1.0	-0.6	-0.5	-0.5	1.6	-1.8	-1.2
Number of treatments/medications taken	0.5	0.9	3.2	-0.7	0.1	0.4	1.1	0.2	-0.5	1.5	0.6	0.1	0.7	0.9	1.8	1.6
Average weekly spirits intake	0.2	0.3	2.3	-0.2	-0.2	-0.3	-0.3	-0.1	1.5	0.4	-0.3	0.2	-0.3	-0.6	0.2	0.5
Sensitivity / hurt feelings	0.5	0.9	2.7	-0.6	0.2	0.9	1.1	0.8	0.2	1.6	0.6	0.2	0.7	0.4	1.4	1.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.0	0.6	0.5	0.4	0.8	0.6	0.4	-0.2	0.5	1.0	0.4	-0.2	-0.3	-0.3
Hearing difficulty/problems: Yes	0.2	0.4	1.2	0.0	-0.6	-0.8	-0.2	-0.9	-0.7	-1.1	-0.5	-0.6	-0.2	-0.3	-0.2	-0.6
Relative age of first facial hair	0.2	0.5	1.6	-1.0	-0.3	-0.1	-0.4	-0.1	-1.2	1.0	-0.1	-0.5	-0.6	0.4	1.1	0.7
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	3.9	1.7	0.6	0.7	0.7	0.8	0.2	-1.8	-0.4	-0.1	-0.4	-1.3	-0.8	-2.0
Ever used hormone-replacement therapy (HRT)	3.4	4.4	9.9	-2.9	-2.8	-3.2	-2.1	-2.9	-2.1	-0.4	-1.7	-1.4	-1.1	2.5	-1.1	0.1
Ever had hysterectomy (womb removed)	1.1	1.2	3.1	-1.4	-1.2	-0.8	-0.9	-1.1	-1.4	-0.0	-1.3	-1.4	-1.8	0.4	-0.8	-0.3
Systolic blood pressure, automated reading	1.1	3.1	8.9	-0.6	1.0	0.8	1.4	0.7	0.5	2.9	2.1	1.1	2.1	1.5	2.5	3.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	2.5	-0.1	0.0	0.2	0.4	0.3	-0.8	0.5	0.3	-0.2	0.5	-0.2	1.6	0.8
Angina	2.4	3.2	6.7	-0.3	1.2	0.5	1.3	0.8	1.1	2.6	2.3	2.4	2.2	1.6	2.2	2.5
Medication for hormone replacement therapy	1.4	1.6	4.0	-0.7	-1.1	-2.0	-1.9	-1.4	-0.8	-0.8	-1.2	-1.1	-1.4	0.1	-1.4	-0.9
Vitamin and mineral supplements	2.3	3.1	5.1	-1.7	-2.1	-2.1	-2.3	-2.0	-1.6	-1.4	-1.9	-1.9	-1.5	1.1	-2.0	-1.1
Supplements: Zinc	0.6	0.6	2.1	0.8	0.8	1.0	0.3	0.8	0.9	0.3	0.4	0.7	0.3	-1.4	1.1	0.4
Medication: Co-codamol	0.2	0.3	0.9	-0.3	-0.6	-0.6	-0.8	-0.6	-0.1	-0.1	-0.6	-1.0	-0.4	0.2	-0.6	-0.0
Medication: Metformin	1.1	1.5	6.1	1.5	0.2	-0.3	-0.2	-0.3	0.2	-2.5	-0.6	-0.1	-0.7	-1.4	-1.8	-2.4
Diabetes (father)	0.6	0.7	2.2	-0.5	-0.7	-1.2	-0.7	-1.0	0.1	-0.5	-1.0	-0.7	-1.5	-0.3	-0.9	-0.9
Diabetes (mother)	5.4	6.8	13.6	-1.2	-2.9	-2.7	-3.7	-2.9	-2.3	-2.7	-3.5	-3.2	-2.8	-0.8	-1.3	-2.1
Severe depression (siblings)	1.2	1.3	2.5	-0.2	-1.1	-1.6	-0.8	-1.0	-1.5	-1.6	-1.2	-1.4	-0.6	0.1	-1.4	-1.3
Pack years adult smoking proportion	0.7	1.1	3.0	-1.3	-1.1	-1.5	-1.2	-1.7	-1.1	-0.1	-0.8	-1.0	-1.0	0.9	-0.5	-0.3
Impedance of leg (right)	0.8	3.7	9.2	-0.3	-1.1	-0.6	-1.9	-0.8	-2.0	-2.2	-2.3	-2.5	-3.0	-1.1	-1.9	-2.8
Leg fat-free mass (left)	0.1	0.3	1.4	0.3	-0.5	-0.3	-0.1	-0.6	0.8	-0.5	-0.8	-0.6	-0.3	-1.2	0.1	-0.1
Trunk fat percentage	0.2	0.6	1.7	-1.2	-1.3	-0.2	-0.2	-0.7	0.4	0.6	-1.0	-0.8	-0.7	-0.3	0.9	0.9
Hand grip strength (right)	0.3	0.8	1.8	-1.4	-0.9	-0.9	-1.1	-1.1	-1.0	0.4	-0.5	-1.0	-0.7	1.3	-0.5	0.2
Townsend deprivation index at recruitment	0.3	0.5	1.7	0.4	-0.6	-0.5	-0.8	-0.7	-0.5	-1.3	-0.8	-0.4	-0.0	-0.2	-0.6	-1.0
Current tobacco smoking	1.3	2.1	4.8	-2.2	-1.7	-1.9	-1.7	-1.8	-1.3	0.3	-1.2	-1.2	-1.5	1.3	-1.0	0.1
Average weekly fortified wine intake	0.5	0.6	1.6	1.3	0.6	-0.2	0.4	0.7	0.7	-1.1	0.2	0.7	0.2	-0.9	-1.0	-1.1
Maternal smoking around birth	0.7	1.0	3.4	-0.5	-0.8	-0.1	-0.7	-0.8	-0.3	-1.3	-1.1	-0.7	-1.2	0.2	-1.9	-1.4
Fed-up feelings	1.0	1.7	4.2	-2.1	-1.6	-1.5	-1.2	-1.8	-1.3	-0.0	-0.8	-0.7	-0.9	2.0	-1.1	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	1.0	0.8	0.6	0.7	0.9	0.3	-0.4	0.6	0.9	0.7	-0.3	0.0	-0.4
Relative age voice broke	1.0	1.5	5.2	-1.1	-1.1	-0.8	-1.2	-1.2	-1.2	-0.4	-1.5	-1.7	-2.3	-0.6	-0.3	-0.8
Taking other prescription medications	1.3	2.0	7.0	-2.0	-1.6	-1.6	-0.6	-1.4	-2.4	-0.3	-0.9	-0.7	-0.2	2.6	-0.2	-0.2
Age when periods started (menarche)	2.0	4.7	17.0	0.9	-1.1	-1.3	-1.8	-1.2	-1.1	-4.1	-2.1	-1.1	-1.7	-1.1	-3.1	-3.9
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.8	-0.1	-0.3	-0.3	-0.2	-0.1	-0.3	-0.5	-0.4	-0.8	-0.0	0.3	-0.9	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.4	8.5	-0.7	-1.8	-2.6	-2.9	-2.2	-1.3	-2.2	-2.5	-2.4	-2.2	-0.1	-2.3	-2.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	2.2	0.1	0.3	0.4	0.8	0.3	-1.5	-0.6	0.2	0.5	-0.2	0.8	-0.4	-1.0
Qualifications: CSEs or equivalent	2.8	3.7	6.2	-2.1	-2.3	-2.1	-2.2	-2.5	-2.4	-0.9	-2.0	-2.2	-2.0	1.0	-1.1	-0.8
Serious illness, injury or assault to yourself	0.3	0.4	1.4	-0.8	-0.3	-0.4	-0.9	-0.6	-0.7	-0.2	-0.2	-0.1	-0.4	1.2	-0.9	-0.4
High blood pressure	0.7	1.9	5.8	-0.8	0.2	-0.0	0.7	-0.0	0.2	1.8	1.3	1.3	1.8	1.6	2.4	2.1
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	-0.3	-0.0	0.1	0.3	-0.1	-0.3	0.5	-0.1	-0.5	-0.5	-0.1	0.0	0.2
Multivitamins +/- minerals	1.5	1.9	4.9	2.1	1.6	1.4	1.2	1.2	2.2	-0.2	1.1	1.6	1.3	-1.3	1.0	-0.2
Stomach or abdominal pain in last month	5.5	6.9	12.7	-2.8	-2.9	-2.3	-2.6	-2.9	-3.6	-1.7	-2.6	-3.0	-2.9	1.7	-2.5	-1.9
Supplements: Glucosamine	2.5	3.3	5.8	1.4	2.2	2.4	2.2	2.1	2.4	1.6	1.9	1.8	1.6	-0.7	1.1	1.3
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	7.4	-0.9	-2.0	-1.4	-2.0	-1.6	-2.7	-1.7	-1.9	-1.7	-0.9	0.3	-0.4	-1.1
Medication: Atenolol	0.4	0.5	1.9	-0.5	0.4	-0.2	0.3	0.1	-0.4	1.0	0.9	0.6	0.9	1.4	0.8	0.9
Medication: Levothyroxine sodium	2.3	3.9	7.8	-1.4	-1.7	-2.8	-1.8	-2.3	-2.3	-1.9	-1.3	-0.7	-1.4	2.0	-2.8	-2.2
Sitting height	0.7	5.2	16.3	3.9	2.2	2.1	2.3	2.2	1.6	-2.2	-0.1	-0.2	-0.7	-4.0	-1.4	-2.6
Chronic bronchitis/emphysema (father)	0.4	0.5	1.5	-0.3	-0.4	-1.1	-0.5	-0.8	-0.2	-0.7	0.1	0.5	0.2	1.1	-1.2	-0.7
High blood pressure (mother)	1.0	1.4	5.8	-1.6	-1.4	-1.0	-0.8	-0.8	-0.6	1.0	-1.1	-2.4	-0.8	0.0	0.1	1.4
Body mass index (BMI)	0.3	1.1	3.6	-1.6	-0.9	-0.6	-0.3	-0.9	0.8	1.6	0.1	0.5	0.4	0.8	1.2	1.9
Impedance of leg (left)	0.6	2.7	6.8	-0.1	-0.8	-0.2	-1.6	-0.5	-1.7	-2.0	-1.8	-2.0	-2.6	-0.8	-1.9	-2.5
Leg predicted mass (left)	0.1	0.3	1.4	0.4	-0.5	-0.3	-0.1	-0.5	0.9	-0.5	-0.8	-0.5	-0.2	-1.2	0.1	-0.1
Trunk fat mass	0.1	0.5	1.5	-0.8	-1.1	-0.2	-0.3	-0.8	0.5	0.1	-1.2	-0.9	-0.9	-0.7	0.6	0.3
Waist circumference	0.2	0.6	1.5	-0.8	-1.0	-0.6	-1.1	-1.2	0.1	0.1	-1.0	-0.7	-1.2	-0.6	0.0	0.0
Number of incorrect matches in round	0.3	0.5	2.3	0.4	0.4	0.1	0.4	0.2	0.7	0.0	0.9	1.0	1.5	1.0	-0.1	0.3
Past tobacco smoking	0.3	0.6	2.2	-0.4	-0.8	-1.1	-1.0	-0.9	0.1	-0.9	-0.6	-0.3	-0.5	0.4	-1.5	-0.8
Alcohol usually taken with meals	2.5	4.1	7.8	2.3	2.8	2.4	2.3	2.7	2.2	0.9	2.4	1.9	1.9	-1.3	0.3	0.8
Nervous feelings	2.7	5.1	10.6	-1.9	-2.4	-1.6	-2.1	-2.0	-3.2	-1.7	-2.8	-2.9	-3.3	-0.1	-1.6	-2.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	-1.1	-1.1	-0.9	-0.5	-1.1	-0.4	-0.1	-0.7	-0.6	-0.8	0.7	-0.3	-0.2
Hearing difficulty/problems with background noise	0.5	0.9	2.8	0.7	0.7	1.0	1.6	0.8	0.2	0.5	0.7	0.1	0.9	-0.8	1.7	0.8
Hair/balding pattern: Pattern 2	2.7	3.4	11.3	-2.8	-1.7	-1.9	-1.7	-2.4	-1.1	0.0	-0.6	-0.2	-1.1	3.4	-2.6	-0.5
Had menopause	0.3	0.4	1.0	-0.8	-0.8	-1.0	-0.6	-0.6	-0.8	-0.4	-0.4	-0.0	-0.2	0.8	-0.5	-0.3
Had other major operations	0.5	0.6	2.0	1.3	0.9	1.4	0.7	1.0	0.2	-0.3	0.7	0.5	0.8	-0.7	0.3	-0.2
Forced vital capacity (FVC)	0.0	0.1	0.6	0.5	0.0	-0.3	-0.3	-0.2	0.8	-0.4	-0.3	-0.4	0.2	-0.3	-0.3	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.8	7.5	-0.5	-1.8	-2.3	-2.7	-1.9	-0.6	-2.0	-2.6	-2.1	-2.3	-0.5	-2.1	-2.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.8	0.2	0.6	0.8	0.8	0.4	-0.9	0.5	1.0	0.7	1.3	0.8	1.0	0.8
Qualifications: None of the above	0.2	0.4	1.5	-1.2	-0.7	-0.3	-0.3	-0.6	-1.0	0.7	-0.1	-0.0	-0.3	1.0	0.3	0.6
Financial difficulties in last 2 years	1.3	1.7	3.8	-1.1	-1.3	-1.3	-1.3	-1.4	-0.8	-0.8	-1.5	-1.6	-2.0	0.0	-1.7	-1.1
Mouth/teeth dental problems	0.4	0.7	1.7	-0.0	-0.7	-0.7	-1.1	-0.8	0.9	-1.1	-0.9	-0.2	-0.6	-0.3	-1.3	-0.9
Heart attack	0.8	1.1	4.0	-0.7	0.5	0.2	-0.1	0.4	1.3	2.0	1.1	1.0	0.7	1.0	0.9	1.7
Allergy	0.1	0.2	0.6	-0.0	-0.3	-0.7	-0.8	-0.4	0.2	-0.7	-0.3	0.2	-0.1	0.0	-0.7	-0.6
Pain all over the body in last month	0.6	0.6	1.2	-0.8	-1.1	-1.0	-0.9	-0.9	0.2	-0.3	-0.9	-1.0	-0.4	0.3	-0.9	0.1
Diabetes (self-reported)	0.5	0.8	2.8	1.4	0.2	-0.1	0.1	-0.3	0.4	-1.7	-0.5	0.1	-0.6	-1.5	-0.6	-1.7
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	4.4	-1.1	-1.0	-1.5	-1.1	-1.1	0.4	-0.1	-1.0	-1.7	-1.4	0.4	-2.1	-0.3
Medication: Ramipril	0.3	0.4	1.3	-0.6	-0.8	-0.7	-1.2	-0.4	0.8	0.4	-0.3	0.1	0.4	0.7	0.1	0.7
Medication: Simvastatin	0.4	0.6	3.6	-0.6	-0.6	-0.5	-0.5	-0.6	-0.2	0.9	-0.4	-0.5	-0.4	-0.2	1.9	0.9
Fluid intelligence score	0.6	1.3	3.1	1.4	1.3	1.8	1.3	1.5	1.7	-0.2	0.6	0.8	0.4	-1.0	-0.7	-0.3
Illnesses of siblings	0.6	0.8	2.3	0.4	1.1	0.7	0.9	0.7	-0.2	0.6	1.4	0.9	0.9	1.5	-1.2	0.1
Neuroticism score	1.1	2.3	5.9	-1.6	-1.9	-1.4	-1.1	-1.4	-2.0	-0.6	-2.0	-2.4	-1.9	-0.1	-0.4	-0.4
Weight	0.1	0.4	1.3	-0.1	-0.8	-0.3	-0.4	-0.8	0.7	-0.4	-1.0	-0.6	-0.7	-1.2	0.1	-0.2
Impedance of arm (right)	0.5	2.3	6.1	-0.6	-1.2	-0.7	-0.5	-0.5	-1.7	-1.5	-2.0	-2.5	-2.5	-0.6	-1.6	-1.9
Arm fat percentage (right)	0.3	1.1	3.7	-1.9	-1.3	-0.6	-0.2	-0.9	0.2	1.5	-0.6	-0.5	-0.4	0.6	1.1	1.6
Trunk fat-free mass	0.2	0.9	3.5	1.7	0.5	0.4	-0.1	0.1	0.6	-1.5	-0.4	-0.1	-0.0	-1.9	-0.3	-1.2
Hip circumference	0.1	0.4	1.6	0.0	-0.6	0.2	0.2	-0.4	-0.0	-0.5	-1.1	-0.8	-0.8	-1.3	0.6	-0.3
Time employed in main current job	1.8	2.1	4.5	-0.4	1.0	0.8	1.8	0.6	0.4	1.7	2.1	2.1	1.8	2.1	0.4	1.6
Alcohol intake versus 10 years previously	4.2	6.3	10.0	-2.4	-3.0	-2.9	-2.8	-3.0	-2.9	-1.8	-3.0	-2.4	-3.2	0.6	-1.5	-2.0
Father’s age at death	4.2	5.7	9.8	0.8	2.3	2.4	2.7	2.4	2.0	2.7	3.1	3.0	2.9	0.7	1.7	2.6
Worrier / anxious feelings	2.4	4.6	8.8	-1.9	-2.6	-2.3	-1.9	-2.2	-2.9	-1.4	-2.6	-3.0	-2.5	0.4	-1.2	-1.3
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	7.1	-2.5	-2.2	-2.7	-1.8	-2.3	-1.8	-0.2	-1.4	-1.2	-1.3	2.0	-0.8	-0.2
Falls in the last year	1.0	1.4	2.8	0.1	0.8	1.3	1.5	1.1	0.8	1.7	1.3	1.3	1.3	0.5	1.1	1.6
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	0.5	0.4	0.4	0.7	0.2	0.1	-0.5	0.3	0.8	0.7	0.4	-0.3	-0.4
Number of live births	2.5	3.5	7.5	-0.3	1.1	2.3	2.5	1.7	-0.2	2.7	1.9	1.3	1.8	1.1	2.7	2.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.9	-0.1	-0.5	-1.0	-1.4	-0.6	1.0	-0.1	-0.7	-0.5	-0.2	-0.4	0.0	0.2
Pulse rate	1.0	1.7	6.2	-0.5	-0.7	-1.5	-1.1	-1.5	-0.1	-1.8	-0.2	0.6	0.1	2.0	-2.5	-1.6
Happiness	0.5	0.6	3.0	0.5	0.1	0.5	0.5	0.1	-0.5	-0.5	-0.7	-0.6	-1.0	-1.7	0.9	-0.7
Noisy workplace	0.8	1.0	3.0	-0.8	-0.1	-0.1	0.5	-0.2	-0.2	1.5	0.7	0.0	1.1	1.7	1.4	1.6
Qualifications: A levels/AS levels or equivalent	1.8	4.0	9.2	1.9	2.3	2.3	2.1	2.7	1.8	1.4	1.5	1.2	1.1	-2.3	3.0	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.1	-0.2	-0.3	0.6	-0.1	-0.2	-0.4	-0.2	-0.2	0.2	0.5	-0.1	-0.2
Mouth/teeth dental problems: Dentures	0.8	1.4	4.8	1.0	1.1	0.9	1.3	1.5	-0.3	1.1	1.2	0.8	1.2	-0.7	2.2	1.1
Asthma	0.2	0.4	1.9	0.5	0.5	1.4	0.5	1.0	-0.2	0.5	0.3	-0.0	0.4	-0.3	0.8	0.5
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	4.7	0.5	1.2	1.3	1.5	1.2	0.9	2.1	1.3	0.0	1.6	-0.2	1.5	2.2
Medication: Cholesterol lowering	0.9	1.3	11.6	0.1	-0.2	-0.4	-0.2	0.1	0.6	1.2	-0.3	-0.3	0.4	-1.1	3.4	1.5
Depression (self-reported)	0.4	0.5	1.0	0.9	0.8	1.0	0.7	0.5	-0.3	-0.6	0.5	0.8	0.0	-0.2	-0.9	-0.9
Medication: Lansoprazole	0.2	0.2	0.9	-0.5	-0.2	-0.1	-0.0	-0.4	0.6	0.5	0.3	0.6	0.2	0.7	-1.0	0.4
Prospective memory result	0.3	0.3	1.3	0.9	0.3	0.1	0.0	0.1	1.1	-0.5	0.3	0.8	0.6	-0.4	-0.7	-0.4
Lung cancer (father)	2.7	3.1	6.1	1.1	1.8	2.5	2.2	2.2	1.4	1.7	2.0	1.6	2.0	-0.2	1.4	1.7
Illnesses of mother	0.7	0.8	4.1	0.4	-0.0	0.1	-0.4	-0.2	-0.2	-1.4	-0.2	0.7	-0.6	0.3	-2.0	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.6	-0.2	-0.5	-1.0	-1.3	-0.7	0.4	-0.2	-0.5	-0.3	-0.1	0.2	0.1	-0.0
Pulse wave Arterial Stiffness index	1.1	1.2	4.0	2.0	1.1	0.5	-0.1	0.9	1.6	-1.4	0.2	0.5	0.4	-1.7	-0.8	-1.2
Impedance of arm (left)	0.4	1.8	5.2	-0.4	-1.1	-0.3	-0.2	-0.3	-1.2	-1.3	-1.9	-2.3	-2.2	-1.1	-1.1	-1.5
Arm fat mass (right)	0.1	0.5	1.6	-1.0	-0.8	-0.2	0.0	-0.6	1.0	1.1	-0.4	-0.3	-0.1	-0.1	0.9	1.3
Trunk predicted mass	0.2	1.0	3.9	1.9	0.6	0.5	-0.0	0.2	0.7	-1.5	-0.4	-0.1	-0.1	-2.0	-0.3	-1.3
Standing height	0.7	6.9	19.7	3.2	0.3	0.7	-0.1	0.2	-0.4	-4.4	-2.4	-2.4	-2.3	-4.3	-2.2	-4.4
Length of working week for main job	2.4	2.7	5.3	-1.9	-2.2	-2.2	-1.9	-2.3	-1.4	-0.4	-2.0	-1.7	-1.6	1.0	-0.1	-0.4
Exposure to tobacco smoke at home	1.0	1.1	3.0	-0.2	-0.8	-0.5	-1.3	-0.8	0.0	-1.4	-1.2	-0.0	-1.6	-0.4	-1.5	-1.7
Breastfed as a baby	0.3	0.3	1.0	0.5	0.7	0.5	0.6	0.6	0.4	0.3	0.8	1.0	0.8	0.5	0.1	0.1
Tense / ‘highly strung’	0.8	1.4	2.5	-1.2	-1.2	-1.3	-1.6	-1.3	-1.1	-0.8	-1.4	-1.1	-1.6	0.3	-0.9	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	2.3	0.5	0.3	0.1	0.4	0.2	-1.5	-0.7	0.2	0.0	0.1	0.1	-0.1	-0.7
Hair/balding pattern: Pattern 4	0.6	1.6	6.9	1.6	1.2	1.1	0.8	1.3	0.8	0.4	0.3	-0.6	0.4	-2.6	2.0	0.7
Birth weight of first child	0.4	0.8	2.6	1.5	0.8	0.9	0.9	1.0	0.0	-0.5	0.1	-0.2	0.5	-1.6	1.0	-0.3
Peak expiratory flow (PEF)	1.1	2.7	6.7	-1.6	-2.1	-2.5	-2.6	-2.1	-0.8	-1.0	-1.9	-1.5	-1.3	0.6	-0.8	-0.6
Pulse wave reflection index	0.7	0.9	2.1	1.1	1.2	0.9	0.7	1.5	1.1	0.5	0.7	0.6	0.7	-1.1	0.9	0.5
Ever highly irritable/argumentative for 2 days	0.8	1.0	3.9	-1.4	-0.6	-1.0	0.3	-0.9	-1.1	0.9	0.3	0.0	0.8	2.0	0.7	1.2
Loud music exposure frequency	0.2	0.2	0.5	0.1	0.6	0.1	0.4	0.3	-0.7	0.7	0.5	0.1	0.1	-0.1	0.7	0.5
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.6	1.0	0.7	0.6	0.4	1.0	1.1	0.3	0.4	0.0	0.8	-1.3	1.2	0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	1.7	-1.0	-0.4	-0.4	-0.3	-0.4	-1.3	0.4	0.0	-0.2	-0.5	0.9	-0.2	0.1
Blood clot in the leg (DVT)	0.8	1.0	1.9	0.3	1.1	1.1	1.2	0.8	0.0	1.1	1.3	0.9	1.4	0.6	1.3	1.1
Medication: Paracetamol	0.4	0.7	3.4	-1.4	-0.8	0.1	-0.1	-0.6	-1.8	0.6	-0.3	-1.0	-0.3	0.9	0.5	0.6
Headache pain in last month	0.4	0.7	3.2	-1.1	-0.9	-1.0	-0.2	-0.8	-1.8	-0.3	-0.4	-0.8	-0.6	0.8	-0.7	-0.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	5.0	-0.1	-0.3	0.0	-0.5	-0.3	-1.1	-1.0	-0.4	-0.5	-1.3	-0.4	-2.2	-1.2
Glaucoma (self-reported)	1.3	1.5	3.7	1.0	1.4	1.2	1.6	1.2	-0.3	0.4	1.8	1.9	1.8	1.0	0.5	0.2
Gout (self-reported)	0.4	0.5	1.4	0.9	0.5	1.0	0.6	1.1	1.2	0.1	0.3	0.2	0.8	-0.6	0.5	0.4
Hypothyroidism/myxoedema (self-reported)	3.6	7.0	13.5	-1.6	-2.4	-3.7	-2.6	-3.0	-3.2	-2.8	-2.3	-1.9	-2.7	1.0	-2.9	-3.0
Medication: Amlodipine	1.2	1.7	3.5	0.5	0.9	0.6	1.0	1.2	1.9	1.2	1.5	1.9	1.8	0.3	1.5	1.3
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.0	-0.9	-0.3	0.2	0.1	0.2	-0.2	1.1	0.4	-0.3	0.8	1.1	0.8	1.4
Birth weight	0.1	0.3	1.9	0.4	0.3	0.4	-0.0	0.3	0.1	-0.3	-0.2	-0.3	-0.9	-1.4	-0.3	-0.6
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.7	-0.2	0.0	0.2	0.6	0.2	-0.2	1.0	0.4	-0.5	0.7	0.0	1.3	1.2
High blood pressure (siblings)	0.7	1.1	6.2	-1.0	-0.8	-0.5	-0.0	-0.5	-0.1	1.1	-0.6	-1.1	-0.1	-0.5	2.5	1.6
Forced vital capacity (FVC), Best measure	0.0	0.1	0.3	0.1	-0.2	-0.6	-0.5	-0.4	0.1	-0.4	-0.3	-0.4	0.2	0.0	0.1	-0.1
Body fat percentage	0.2	0.8	2.6	-1.6	-1.4	-0.4	-0.5	-1.0	0.1	0.7	-1.0	-0.8	-1.0	0.0	0.6	0.8
Leg fat percentage (right)	0.3	1.2	4.0	-2.0	-1.5	-0.9	-1.4	-1.5	-0.2	0.7	-1.0	-0.5	-1.2	0.7	0.2	0.6
Arm fat-free mass (right)	0.1	0.6	2.9	1.4	0.3	0.3	-0.2	-0.1	0.9	-1.1	-0.4	-0.0	0.1	-1.7	-0.0	-0.8
Exposure to tobacco smoke outside home	0.8	1.1	2.7	-0.9	-1.2	-1.4	-1.1	-1.7	0.1	-0.7	-0.9	-0.1	-0.8	1.0	-1.6	-0.8
Comparative body size at age 10	1.7	4.8	16.2	-1.9	0.4	0.8	1.8	0.7	0.7	4.0	2.1	1.3	2.3	2.6	2.0	4.0
Number of full brothers	0.2	0.3	0.9	0.4	0.1	0.2	-0.2	-0.2	-0.9	-0.6	-0.3	0.2	-0.7	-0.7	0.4	-1.0
Worry too long after embarrassment	0.1	0.2	0.8	0.2	-0.2	0.4	-0.1	0.2	-0.2	-0.4	-0.6	-0.9	-0.3	-0.9	-0.0	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	5.9	0.5	-0.5	-0.7	-1.5	-0.7	-0.9	-2.2	-1.2	-0.8	-1.7	-1.1	-2.2	-2.4
Wheeze or whistling in the chest in last year	0.9	1.6	8.9	-1.8	-0.8	-0.2	-0.0	-0.9	-3.0	0.5	0.0	-0.3	0.3	2.6	0.3	0.5
Number of children fathered	0.5	0.5	2.4	-0.5	0.4	0.6	0.7	0.4	0.3	1.6	0.6	0.1	0.3	0.1	0.7	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.4	0.1	0.5	0.6	1.0	0.6	-0.0	1.0	0.8	0.3	1.0	0.1	1.2	1.1
Age at first live birth	1.9	3.3	8.5	2.4	2.5	1.9	2.2	2.3	2.9	0.5	1.6	1.3	0.9	-2.0	-0.3	0.1
Pulse wave peak to peak time	0.8	1.0	3.0	-1.7	-1.1	-0.4	0.0	-0.9	-1.6	1.0	-0.3	-0.6	-0.5	1.4	0.6	0.9
Health satisfaction	0.2	0.3	0.8	-0.3	0.1	0.3	0.7	-0.2	-0.9	0.3	0.3	0.3	0.4	0.9	0.8	0.2
Shortness of breath walking on level ground	0.7	0.8	1.8	0.9	1.3	0.9	1.2	0.4	0.8	0.3	1.3	1.3	1.1	0.4	0.0	0.1
Qualifications: College or University degree	1.5	4.6	11.3	2.7	2.3	2.3	2.3	2.9	2.7	0.9	1.2	0.5	0.8	-3.4	2.3	0.8
Eye problems/disorders: None of the above	0.7	0.9	6.4	-0.1	-0.2	0.1	-0.7	0.3	2.5	0.9	-0.1	0.1	-0.2	-1.3	0.4	1.2
Mouth/teeth dental problems: Loose teeth	1.0	1.2	4.5	-2.1	-0.8	-0.4	-0.1	-0.7	-1.2	1.6	0.2	-0.2	-0.2	1.8	0.4	1.5
Emphysema/chronic bronchitis	2.2	2.5	10.4	-1.6	-1.4	-1.6	-0.8	-1.8	-3.2	-0.5	-1.0	-1.4	-1.2	2.0	-1.1	-0.9
Medication for pain relief, constipation, heartburn	1.0	1.8	5.6	0.7	-0.3	-0.7	-1.3	-0.4	0.1	-2.2	-1.1	-0.3	-1.5	-0.9	-2.3	-2.4
Neck or shoulder pain in last month	5.5	7.8	15.3	-2.6	-2.9	-3.6	-2.7	-3.6	-3.9	-2.4	-2.1	-2.0	-1.3	3.3	-2.7	-1.9
Medication: Blood pressure	0.9	1.5	5.1	-0.9	-0.2	-0.6	0.3	-0.4	1.0	1.4	0.9	1.2	1.7	2.3	1.6	1.6
Angina (self-reported)	2.1	2.7	5.7	-0.2	1.1	0.5	1.2	0.8	0.9	2.2	2.2	2.4	2.1	1.7	1.9	2.1
Migraine (self-reported)	0.1	0.1	0.2	-0.4	-0.5	-0.3	-0.3	-0.3	0.1	-0.1	-0.2	-0.3	0.3	0.4	0.3	0.2
Medication: Ibuprofen	0.4	0.5	1.2	0.5	0.6	0.5	0.7	0.6	0.1	1.0	0.3	-0.6	0.5	-0.8	1.1	1.1
Medication: Allopurinol	0.9	1.2	3.0	-0.2	-1.3	-1.1	-1.3	-1.0	0.3	-1.3	-1.7	-1.5	-1.0	-0.3	-0.7	-1.0
Medication: Omeprazole	1.2	1.4	2.8	-1.2	-1.3	-1.1	-1.4	-1.6	-1.7	-1.1	-1.0	-0.4	-0.7	1.7	-0.9	-1.0
Medication: Seretide 50 evohaler	0.4	0.4	1.7	-0.2	0.5	-0.0	0.8	-0.1	0.2	0.5	0.9	1.2	0.6	1.3	-0.4	0.2
Mean time to correctly identify matches	2.6	5.0	16.6	1.5	1.9	1.5	1.5	1.5	4.1	0.9	2.6	4.0	3.1	0.9	0.5	1.1
Heart disease (mother)	0.1	0.2	1.3	-0.2	-0.2	-1.1	-0.4	-0.3	0.5	-0.5	-0.3	0.2	-0.2	0.0	-0.0	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	3.8	-1.7	-1.6	-1.5	-1.1	-1.9	-2.0	-0.4	-1.2	-1.2	-1.1	1.2	-0.5	-0.3
Whole body fat mass	0.1	0.5	1.4	-1.1	-1.2	-0.3	-0.3	-1.0	0.4	0.4	-1.1	-0.7	-0.8	-0.3	0.5	0.5
Leg fat mass (right)	0.2	0.8	2.0	-1.4	-1.3	-0.8	-1.0	-1.4	0.3	0.3	-1.1	-0.7	-1.1	0.2	0.0	0.3
Arm predicted mass (right)	0.1	0.6	2.5	1.4	0.4	0.4	-0.1	0.0	1.1	-0.9	-0.3	0.2	0.1	-1.6	0.1	-0.6
Pulse rate, automated reading	1.8	5.8	12.5	-1.7	-2.3	-2.9	-2.3	-3.2	-1.8	-2.7	-2.0	-0.9	-2.1	1.8	-3.5	-2.8
Alcohol intake frequency.	4.0	9.3	15.8	-2.9	-3.5	-3.7	-3.9	-4.0	-2.8	-2.0	-3.2	-2.8	-3.2	1.7	-2.9	-2.1
Comparative height size at age 10	0.9	4.7	15.7	2.6	0.1	-0.0	-0.6	-0.1	-0.2	-4.0	-1.9	-1.4	-1.8	-3.1	-2.0	-3.9
Number of full sisters	1.4	1.7	5.0	-0.7	-1.6	-1.5	-1.5	-1.2	-1.2	-0.9	-2.0	-2.2	-1.2	-0.3	-0.3	-0.6
Suffer from ‘nerves’	4.4	7.0	13.0	-1.4	-3.0	-2.4	-2.7	-2.2	-3.2	-2.6	-3.5	-3.6	-3.3	-1.1	-1.0	-2.3
Overall health rating	2.5	5.4	10.8	-3.1	-2.8	-3.3	-2.3	-3.2	-3.0	-0.7	-1.6	-1.2	-1.2	3.2	-1.0	-0.5
Chest pain or discomfort	1.1	1.7	6.7	-1.3	-1.4	-1.4	-1.1	-1.4	-2.6	-0.6	-1.1	-1.5	-0.8	0.8	0.4	-0.4
Had major operations	0.2	0.2	1.3	0.4	0.2	0.0	0.7	0.3	-1.2	-0.2	0.0	-0.6	0.4	-0.0	0.7	-0.0
Age at last live birth	0.9	1.3	6.5	1.4	1.0	1.1	0.9	1.4	1.6	0.0	-0.1	-0.7	-0.8	-2.6	-0.2	-0.3
Family relationship satisfaction	0.2	0.3	1.1	0.6	0.5	1.0	0.8	0.5	0.3	0.0	0.4	0.7	0.4	-0.1	-0.0	-0.2
Leg pain on walking	1.1	1.4	2.3	1.1	1.3	1.5	1.5	1.1	1.3	0.8	1.4	1.2	1.5	-0.1	1.1	0.7
Qualifications: NVQ or HND or HNC or equivalent	3.4	4.1	8.1	-1.8	-2.6	-2.8	-2.6	-2.7	-1.7	-1.7	-2.1	-1.9	-1.2	1.7	-1.6	-1.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.4	-0.3	-0.1	0.1	-0.7	-0.2	0.0	-0.0	-0.4	-0.8	-1.0	-0.3	-1.2	-0.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	3.1	1.6	0.4	0.4	-0.2	0.5	0.6	-1.0	-0.2	-0.1	0.3	-1.8	-0.0	-0.6
Medication: Aspirin	1.3	1.7	4.3	0.3	0.7	0.1	1.1	0.8	1.3	1.2	1.4	2.1	1.8	0.5	2.0	1.4
Supplements: Vitamin C	2.1	2.5	4.5	1.2	2.0	2.1	1.9	2.1	0.8	1.4	1.9	1.7	1.2	-1.0	1.3	1.0
Knee pain experienced in last month	0.1	0.1	0.6	0.1	-0.1	0.0	0.3	0.3	0.2	0.3	-0.2	-0.2	0.0	-0.4	0.8	0.3
Hypertension (Self-reported)	0.8	2.2	6.2	-1.5	-0.3	-0.5	0.4	-0.5	-0.1	2.0	1.0	1.1	1.6	2.2	2.5	2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.3	-1.1	-1.1	-1.0	-0.9	-0.8	-1.5	0.1	-0.4	-0.6	-0.3	1.1	-0.1	0.4
Illnesses of father: Heart disease	0.6	0.8	2.7	1.1	0.2	-0.0	-0.9	0.3	0.5	-1.3	-0.7	-0.2	-1.0	-1.3	-0.5	-1.6
Illnesses of siblings: Diabetes	0.6	0.7	3.2	0.7	-0.1	0.1	-0.8	-0.1	-0.2	-1.1	-0.8	-0.2	-1.2	-1.8	0.0	-1.2
Smoking status: Previous	0.4	0.7	1.6	1.0	0.9	1.3	1.1	1.1	-0.2	0.0	0.4	0.3	0.5	-0.8	1.2	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	2.7	5.6	10.2	-0.2	-2.2	-2.0	-2.4	-1.9	-1.9	-2.8	-3.2	-3.2	-3.1	-1.8	-1.6	-2.7
Whole body fat-free mass	0.1	0.5	2.2	1.1	0.0	0.1	-0.2	-0.3	0.7	-1.1	-0.6	-0.3	-0.1	-1.5	-0.1	-0.7
Leg fat-free mass (right)	0.0	0.2	1.1	0.5	-0.3	-0.1	0.1	-0.4	0.9	-0.3	-0.5	-0.4	0.1	-1.1	0.2	0.1
Arm fat percentage (left)	0.3	1.2	3.8	-1.9	-1.3	-0.4	-0.1	-0.8	0.4	1.7	-0.6	-0.5	-0.3	0.5	1.3	1.9
Average weekly red wine intake	4.0	6.0	11.6	3.4	3.1	3.2	3.1	3.1	2.9	0.3	1.9	2.1	1.8	-2.4	1.0	0.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	3.7	-0.4	0.1	-0.5	-0.2	-0.4	0.5	0.5	0.6	0.7	1.3	1.9	0.2	0.7
Mood swings	1.2	2.1	5.3	-2.1	-1.8	-1.2	-0.5	-1.2	-2.3	0.6	-1.5	-2.3	-1.5	0.7	0.7	0.5
Loneliness, isolation	1.7	2.4	5.8	-1.4	-2.0	-1.7	-1.2	-1.7	-2.4	-0.8	-1.9	-2.0	-1.6	0.3	-0.4	-0.7
Long-standing illness, disability or infirmity	0.3	0.4	1.3	-0.1	-0.5	-0.6	0.0	-0.5	-0.8	-1.2	-0.6	-0.7	-0.1	0.6	-0.9	-0.9
Ever had bowel cancer screening	3.1	3.6	6.3	-1.6	-2.5	-1.9	-2.0	-2.1	-2.5	-1.5	-2.5	-2.4	-2.0	-0.1	-0.5	-1.0
Diabetes diagnosed by doctor	0.5	0.9	3.0	1.2	0.1	0.2	0.3	-0.2	0.0	-1.7	-0.6	0.0	-0.8	-1.5	-0.4	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.0	-0.3	-0.3	-0.3	-1.0	-0.3	-0.0	-0.2	-0.2	0.0	-0.2	0.4	-0.8	-0.2
Friendships satisfaction	0.4	0.5	1.2	-0.5	-0.7	-1.1	-0.2	-1.1	-0.5	-0.0	-0.8	-1.0	-1.0	-0.3	-0.2	-0.2
Qualifications: nursing, teaching	0.7	1.1	6.4	1.6	1.0	0.4	0.6	1.0	2.5	-0.4	0.3	0.5	0.5	-1.3	-0.5	-0.4
Commuting to job workplace: Walk	2.0	2.2	3.9	1.8	1.7	1.7	1.9	2.0	1.6	0.4	1.3	1.4	1.5	-0.9	1.5	0.3
Eye problems/disorders: Cataract	0.5	0.6	2.5	-0.0	0.6	0.7	1.6	0.8	-0.8	0.8	0.7	0.2	0.7	0.6	0.8	0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.5	1.0	0.6	0.6	0.7	0.5	0.8	-0.7	0.1	0.4	-0.3	-0.7	-1.2	-1.0
Medication for cholesterol	0.4	0.6	1.2	1.1	1.1	0.9	1.1	0.8	0.9	0.1	0.8	0.5	0.9	-0.3	0.1	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.1	0.4	0.7	0.8	0.7	0.7	0.6	0.7	0.4	0.1	0.5	-0.5	1.4	0.6
Back pain experienced in last month	0.6	0.9	4.5	-1.4	-0.5	-0.6	-0.2	-1.0	-1.0	0.6	0.2	0.7	0.6	2.1	0.6	0.6
Mineral and other dietary supplements	4.7	6.3	11.4	-2.0	-2.7	-3.2	-3.4	-3.3	-2.2	-2.3	-2.5	-1.9	-2.1	1.4	-2.7	-2.1
Breast cancer (self-reported)	0.3	0.4	1.1	-0.7	-0.5	-0.4	-0.6	-0.9	-0.0	-0.5	-0.1	0.5	-0.1	0.9	-1.0	-0.3
Asthma (self-reported)	0.3	0.6	2.4	0.7	0.8	1.5	0.6	1.2	0.1	0.7	0.5	0.1	0.5	-0.5	1.0	0.6
Osteoporosis (self-reported)	1.1	1.4	3.0	0.4	1.3	1.1	1.1	1.0	0.9	1.7	1.4	1.4	1.0	0.2	1.6	1.3
Osteoarthritis (self-reported)	0.6	0.7	1.6	-0.4	-1.3	-0.8	-1.0	-0.9	-1.1	-0.9	-1.2	-1.0	-0.3	-0.2	0.8	-0.3
Medication: Aspirin	1.2	1.6	4.8	0.4	0.7	0.1	1.1	0.8	1.6	1.1	1.3	2.2	1.7	0.5	1.7	1.2
Medication: Gliclazide	1.4	1.6	5.6	2.2	0.6	0.1	0.3	0.1	0.7	-2.4	-0.5	0.3	-0.3	-1.7	-0.7	-2.3
Illnesses of father: None of the above (group 1)	0.8	1.0	2.5	1.0	1.2	1.6	1.6	1.2	0.2	0.5	1.0	0.8	1.0	-0.6	0.6	0.6
Smoking status: Current	1.2	1.8	5.2	-2.3	-1.5	-1.8	-1.5	-1.6	-1.1	0.8	-0.9	-1.0	-1.4	1.5	-0.7	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.5	-0.5	-0.3	-0.9	-0.8	-0.3	1.1	1.0	0.2	0.7	0.8	0.9	1.2	1.2
Whole body water mass	0.1	0.5	2.4	1.2	0.0	0.1	-0.2	-0.3	0.7	-1.1	-0.6	-0.3	-0.1	-1.6	-0.2	-0.8
Leg predicted mass (right)	0.0	0.3	1.3	0.6	-0.2	0.0	0.2	-0.3	1.0	-0.3	-0.4	-0.3	0.2	-1.2	0.3	0.1
Arm fat mass (left)	0.2	0.6	1.5	-1.2	-1.2	-0.4	-0.3	-0.9	0.7	0.9	-0.8	-0.5	-0.4	-0.1	0.8	1.1
Number of self-reported non-cancer illnesses	1.2	2.0	5.8	-1.7	-2.0	-1.5	-1.3	-1.5	-2.4	-0.6	-1.4	-1.5	-0.7	1.5	0.4	-0.1
Average weekly champagne plus white wine intake	3.1	4.3	7.4	2.4	2.3	2.7	1.9	2.7	2.5	1.0	1.7	1.8	1.5	-2.5	2.1	1.1
Miserableness	0.4	0.7	2.3	-1.2	-0.7	-0.7	0.4	-0.2	-0.5	1.3	0.0	-0.4	0.3	0.9	0.7	1.5
Guilty feelings	2.2	3.3	6.8	2.4	2.1	2.4	2.3	2.6	1.3	0.6	1.2	0.7	1.3	-2.2	2.1	0.5
Wears glasses or contact lenses	2.5	2.9	5.2	1.1	1.8	1.9	2.3	2.0	1.1	1.4	2.1	1.7	2.3	0.1	1.9	1.5
Ever taken oral contraceptive pill	1.6	1.7	4.2	-2.0	-1.8	-1.4	-1.4	-1.9	-1.6	0.1	-1.1	-1.0	-1.2	1.1	0.3	0.1
Hearing aid user	0.2	0.3	1.4	0.2	0.1	-0.3	-0.2	-0.4	0.3	-0.6	0.2	0.4	0.1	0.6	-1.2	-0.7
Mother’s age at death	1.9	2.4	5.1	1.6	1.8	1.7	1.5	1.9	-0.0	1.0	1.8	1.3	1.9	-0.8	2.3	1.1
Financial situation satisfaction	0.4	0.5	1.9	1.3	0.6	0.6	0.5	0.5	-0.2	-1.0	-0.0	0.0	-0.1	-1.4	0.4	-1.0
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.4	1.1	-0.3	-0.7	-1.2	-0.6	1.2	-1.8	-1.2	-0.7	-1.0	-1.7	-1.4	-1.7
Commuting to job workplace: Public transport	0.3	0.4	1.4	0.9	0.4	0.0	-0.1	0.1	0.1	-1.0	-0.1	0.4	-0.3	-0.7	-0.6	-1.2
Eye problems/disorders: Glaucoma	0.7	0.8	2.3	0.3	0.9	0.7	1.1	0.4	-0.7	0.5	1.3	1.2	1.5	1.2	0.5	0.4
Medication: Blood pressure	0.3	0.6	1.6	-0.1	0.2	0.5	0.2	0.6	0.9	1.0	0.7	0.9	1.0	0.2	0.8	1.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.8	-0.9	-0.3	-0.7	0.2	-0.5	-1.3	0.4	-0.1	-0.2	-0.6	1.0	0.1	0.1
Supplements: Fish oil (including cod liver oil)	6.5	8.5	14.3	2.2	3.1	3.4	3.8	3.7	2.4	2.7	3.1	2.4	3.0	-1.2	3.2	2.7
High cholesterol (Self-reported)	2.4	4.3	10.0	-1.3	-2.4	-1.7	-2.3	-1.7	-1.2	-0.4	-3.0	-3.2	-2.7	-2.4	1.9	-0.0
Medication: Bendroflumethiazide	0.8	1.3	4.4	-0.9	0.2	-0.2	0.6	-0.1	0.5	1.7	1.3	1.1	1.4	2.1	0.5	1.7
Medication: Paracetamol	0.6	0.9	2.9	-1.3	-1.1	-0.5	-0.6	-0.8	-1.7	0.1	-0.9	-1.5	-1.1	0.2	0.3	0.0
Medication: Lisinopril	1.2	1.6	4.0	-0.1	1.2	1.1	1.4	1.1	1.4	2.0	1.6	1.0	1.1	0.5	0.5	1.8
Medication: Atorvastatin	0.8	1.0	2.7	-0.6	-1.3	-1.6	-1.4	-0.8	-0.0	-0.6	-1.5	-1.1	-1.0	-0.6	0.5	-0.2
Illnesses of father: High blood pressure	3.8	4.7	14.1	-3.8	-2.6	-2.8	-2.2	-3.0	-1.4	1.3	-1.0	-1.4	-0.7	2.9	-0.5	1.6
Alcohol drinker status: Never	0.1	0.2	1.0	-0.3	-0.1	-0.2	0.0	-0.4	0.7	-0.0	-0.1	-0.3	-0.4	0.4	-1.0	-0.2
Ever smoked	0.9	1.6	3.5	0.3	1.3	1.4	1.3	1.3	0.4	1.9	1.4	1.0	1.1	0.2	1.8	1.6
Basal metabolic rate	0.1	0.4	2.0	0.8	-0.2	-0.1	-0.3	-0.4	0.7	-0.9	-0.7	-0.5	-0.3	-1.4	-0.0	-0.5
Leg fat percentage (left)	0.3	1.1	4.0	-2.0	-1.4	-0.8	-1.3	-1.4	-0.1	0.9	-0.8	-0.2	-0.9	0.8	0.5	0.8
Arm fat-free mass (left)	0.1	0.5	2.3	1.2	0.1	0.2	-0.3	-0.2	0.7	-1.1	-0.5	-0.2	-0.2	-1.5	-0.1	-0.9
Number of operations (self-reported)	0.9	1.4	2.7	1.3	1.4	1.6	1.5	1.3	-0.8	0.4	1.3	0.5	1.4	-0.3	1.7	0.5
Average weekly beer plus cider intake	0.3	0.4	1.7	0.9	0.3	0.4	-0.5	0.4	0.5	-0.4	-0.5	-0.4	-0.7	-1.3	0.5	-0.8
Irritability	0.5	0.9	3.1	-1.2	-0.6	-0.4	0.0	-0.4	-1.8	0.8	-0.0	-0.8	0.3	1.1	1.5	1.1
Risk taking	1.1	1.6	3.8	0.6	-0.7	-0.8	-0.8	-0.8	-0.3	-1.7	-1.8	-1.4	-1.7	-2.0	-0.3	-1.7
Ever had prostate specific antigen (PSA) test	2.1	2.4	4.9	2.2	1.7	1.9	2.0	2.1	1.3	-0.1	1.0	1.0	1.4	-1.9	1.4	0.2
Fractured/broken bones in last 5 years	1.1	1.4	4.6	1.3	1.7	1.0	1.6	1.1	0.8	0.2	1.7	2.1	1.0	0.1	0.3	-0.3
Age started oral contraceptive pill	1.0	1.2	7.1	-0.6	-0.1	-0.2	0.7	-0.4	0.5	0.1	1.0	1.9	1.4	2.7	-0.9	0.2
Diastolic blood pressure, automated reading	0.2	0.7	2.5	-1.0	-0.2	-0.8	-0.7	-0.6	0.6	1.5	0.4	-0.3	0.3	0.8	0.4	1.6
Ever depressed for a whole week	0.6	0.7	2.4	1.6	1.2	1.1	0.8	1.0	0.5	-0.2	0.6	0.5	0.6	-0.8	0.5	-0.3
Unable to work because of sickness or disability	0.9	1.2	5.0	1.2	0.3	0.4	-0.3	-0.2	-0.3	-1.9	-0.6	-0.0	-1.0	-1.1	-1.7	-2.2
Commuting to job workplace: Cycle	0.2	0.3	0.8	-0.5	-0.9	-0.2	-0.2	-0.2	-0.7	-0.3	-0.7	-0.9	0.2	0.4	0.7	0.2
Myopia	0.5	0.7	3.2	0.1	0.4	0.3	0.1	0.4	1.8	0.6	0.9	1.3	1.3	0.8	0.3	0.8
Vascular/heart problems diagnosed by doctor	0.6	1.7	6.2	1.0	0.1	0.3	-0.3	0.3	-0.3	-1.8	-1.0	-1.1	-1.6	-1.6	-2.5	-2.1
Cholesterol lowering medication	0.7	1.1	2.3	-1.2	-1.4	-1.0	-1.3	-1.1	-0.3	-0.0	-1.5	-1.3	-1.5	-0.5	0.5	0.1
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	3.7	-1.4	-1.6	-1.7	-1.8	-1.9	-1.3	-1.3	-1.1	-0.1	-0.8	1.8	-1.8	-1.2
Pain experienced in last month	1.2	2.0	4.9	2.2	1.7	1.6	1.0	1.7	2.1	0.1	1.1	1.1	0.7	-2.2	0.3	0.0
Supplements: Calcium	1.7	1.9	3.6	0.9	1.9	1.9	1.8	1.5	0.8	1.3	1.7	1.8	0.8	-0.4	1.1	0.8
Basal cell carcinoma (self-reported)	0.3	0.4	1.5	-0.2	0.1	0.6	0.6	0.4	-0.0	1.0	0.2	-0.4	0.0	-0.7	1.2	1.0
Heart attack/myocardial infarction (self-reported)	0.8	1.1	4.0	-0.6	0.6	0.2	-0.0	0.5	1.2	2.0	1.1	1.1	0.7	0.9	1.0	1.7
Deep venous thrombosis (DVT) (self-reported)	0.7	1.0	2.1	0.5	1.1	1.0	1.1	0.7	-0.1	0.9	1.3	1.0	1.4	0.5	1.1	0.9
Heart disease (siblings)	1.8	2.2	4.6	-1.9	-2.1	-1.9	-1.7	-1.8	-1.2	-0.3	-1.9	-1.3	-1.5	0.4	1.0	0.0
Alcohol drinker status: Previous	1.3	1.5	2.7	-0.3	-1.0	-1.1	-1.6	-1.2	-0.9	-1.5	-1.5	-0.9	-1.6	-0.5	-1.1	-1.6
Pack years of smoking	0.4	0.6	2.0	-1.0	-0.8	-1.2	-0.7	-1.4	-0.9	0.0	-0.3	-0.5	-0.5	1.1	-0.4	-0.1
Impedance of whole body	0.5	2.6	6.9	-0.4	-1.1	-0.3	-0.9	-0.5	-1.9	-1.7	-2.1	-2.5	-2.6	-1.0	-1.3	-2.0
Leg fat mass (left)	0.1	0.5	1.5	-1.2	-1.0	-0.4	-0.7	-1.0	0.6	0.6	-0.8	-0.3	-0.8	0.2	0.3	0.6
Arm predicted mass (left)	0.1	0.4	2.1	1.0	0.0	-0.0	-0.4	-0.3	0.5	-0.9	-0.6	-0.3	-0.2	-1.4	0.1	-0.7