Hub : Genes

PXK

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1190 0.0480 1.8e-04 0.003 0.028 0.005 0.028 0.002 1.3e-01 2.0e-04 6.9e-02 1.9e-04 1.8e-01
2 GTEx Adipose Subcutaneous 0.0930 0.0320 1.4e-04 0.049 NA 0.024 NA 0.042 6.7e-05 NA 4.5e-03 NA 2.2e-04
3 GTEx Adipose Visceral Omentum 0.1770 0.0600 8.6e-05 0.123 NA 0.008 NA 0.050 6.1e-07 NA 1.1e-01 NA 1.3e-03
4 GTEx Adrenal Gland 0.1783 0.0689 2.7e-03 0.099 NA 0.013 NA 0.065 2.1e-04 NA 1.1e-01 NA 2.4e-03
5 GTEx Artery Aorta 0.2550 0.0970 8.5e-04 0.002 NA 0.012 NA 0.021 2.4e-01 NA 7.1e-02 NA 2.3e-02
6 GTEx Artery Tibial 0.1418 0.0418 2.5e-06 0.071 NA 0.102 NA 0.086 2.9e-06 NA 2.1e-08 NA 2.7e-07
7 GTEx Brain Cerebellar Hemisphere 0.2490 0.0830 8.3e-04 0.016 NA 0.024 NA 0.045 1.2e-01 NA 7.8e-02 NA 2.7e-02
8 GTEx Breast Mammary Tissue 0.1640 0.0700 2.3e-03 0.047 NA 0.057 NA 0.033 1.8e-03 NA 6.7e-04 NA 7.7e-03
9 GTEx Breast Mammary Tissue (Male) 0.0891 0.1058 2.1e-01 -0.005 NA -0.013 NA 0.000 4.3e-01 NA 9.4e-01 NA 3.2e-01
10 GTEx Breast Mammary Tissue (Female) 0.0799 0.0651 1.3e-01 -0.010 NA 0.006 NA -0.002 8.6e-01 NA 2.1e-01 NA 3.8e-01
11 GTEx Cells EBV-transformed lymphocytes 0.1500 0.0640 6.6e-03 0.133 NA -0.003 NA 0.039 4.2e-05 NA 4.0e-01 NA 2.1e-02
12 GTEx Cells Transformed fibroblasts 0.1170 0.0390 3.3e-05 0.130 NA 0.110 NA 0.121 5.7e-10 NA 1.4e-08 NA 2.5e-09
13 GTEx Esophagus Muscularis 0.1000 0.0490 9.4e-03 0.051 NA 0.023 NA 0.053 4.9e-04 NA 1.4e-02 NA 3.8e-04
14 GTEx Liver 0.2360 0.0820 3.0e-03 0.000 NA 0.020 NA 0.011 3.1e-01 NA 9.2e-02 NA 1.5e-01
15 GTEx Muscle Skeletal 0.0675 0.0249 4.5e-04 0.036 NA 0.028 NA 0.030 1.7e-04 NA 9.2e-04 NA 6.0e-04
16 GTEx Nerve Tibial 0.4658 0.0675 0.0e+00 0.274 NA 0.299 NA 0.277 1.5e-19 NA 1.6e-21 NA 9.4e-20
17 GTEx Pancreas 0.1370 0.0510 2.5e-03 0.081 NA 0.109 NA 0.094 2.7e-04 NA 2.6e-05 NA 8.9e-05
18 GTEx Pituitary 0.3080 0.0970 1.4e-04 0.110 NA 0.090 NA 0.091 1.1e-03 NA 2.9e-03 NA 2.8e-03
19 GTEx Small Intestine Terminal Ileum 0.3560 0.1430 7.8e-03 0.239 NA 0.158 NA 0.177 4.3e-06 NA 2.2e-04 NA 9.2e-05
20 GTEx Spleen 0.3340 0.0830 1.1e-05 0.126 NA 0.170 NA 0.180 4.1e-04 NA 3.8e-05 NA 2.2e-05
21 GTEx Thyroid 0.1130 0.0360 2.9e-05 0.090 NA 0.045 NA 0.066 2.0e-07 NA 2.2e-04 NA 9.4e-06
22 GTEx Whole Blood 0.0550 0.0260 7.4e-03 0.065 NA 0.061 NA 0.062 1.3e-06 NA 2.7e-06 NA 2.4e-06
23 METSIM Adipose 0.0369 0.0147 5.2e-04 0.018 0.018 0.023 0.018 0.025 9.5e-04 9.7e-04 1.9e-04 8.7e-04 8.9e-05
24 NTR Blood 0.0403 0.0113 2.2e-10 0.034 0.032 0.040 0.033 0.038 3.5e-11 1.4e-10 8.5e-13 8.0e-11 2.8e-12
25 ROSMAP Brain Pre-frontal Cortex 0.2368 0.0392 0.0e+00 0.266 0.271 0.304 0.300 0.297 4.1e-34 8.7e-35 1.1e-39 4.4e-39 1.1e-38
26 TCGA Breast Invasive Carcinoma 0.0226 0.0129 8.1e-04 0.011 0.017 0.009 NA 0.011 2.4e-03 1.5e-04 4.3e-03 NA 1.9e-03
27 TCGA Kidney Renal Clear Cell Carcinoma 0.0547 0.0273 3.4e-06 0.027 0.049 0.053 NA 0.049 4.1e-04 2.8e-06 1.2e-06 NA 3.0e-06
28 TCGA Prostate Adenocarcinoma 0.1233 0.0582 6.2e-06 0.010 0.060 0.064 NA 0.043 2.9e-02 6.6e-07 2.9e-07 NA 2.6e-05
29 TCGA Testicular Germ Cell Tumors 0.0950 0.0530 3.2e-03 0.052 0.071 0.083 NA 0.052 6.3e-03 1.6e-03 7.4e-04 NA 6.5e-03
30 TCGA Thyroid Carcinoma 0.1170 0.0460 3.7e-08 0.100 0.101 0.103 NA 0.101 6.2e-10 5.0e-10 3.5e-10 NA 5.1e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
Bipolar Disorder (2018) 0.7 1.1 4.4 0.9 -0.2 -1.1 -1.5 -1.0 -1.2 -0.3 -1.1 0.7 0.0 -1.1 -0.4 0.1 -0.9 -1.0 -1.3 -1.3 -1.0 -0.1 -1.7 -0.0 0.5 -1.9 -2.1 -0.4 -0.0 -0.9 -1.7 -1.0 0.4
Bipolar Disorder or Schizophrenia 0.4 1.0 5.0 1.5 1.1 0.1 0.1 0.1 0.0 -0.2 0.1 -0.5 0.0 0.1 -1.9 1.7 -0.3 0.8 0.3 0.7 0.7 1.1 -0.3 1.5 1.9 -0.9 -1.1 0.8 -1.5 -0.2 -2.2 -1.0 0.4
Depressed Affect (Nagel 2018) 0.6 1.4 5.0 -1.6 -0.6 1.1 2.0 1.3 1.0 -1.6 1.7 0.7 0.0 1.1 0.7 0.3 -1.3 1.4 2.2 2.2 1.0 1.2 0.9 0.0 -0.6 0.1 0.4 -0.4 -1.5 -0.5 0.4 -1.2 -0.9
Depression (Nagel 2018) 0.5 0.7 2.3 0.6 0.9 0.6 0.5 0.7 1.4 0.1 0.4 -0.6 0.0 0.6 -0.8 0.8 0.9 0.6 0.5 0.4 0.6 1.5 1.1 0.7 1.0 1.3 1.2 1.1 0.0 1.4 0.8 1.2 0.6
Intelligence (Savage-Jansen 2018) 0.1 0.4 2.0 1.1 0.7 0.5 -0.4 -0.2 -1.0 1.4 -0.5 -0.6 0.0 0.5 -0.3 0.3 1.2 0.0 -0.7 -0.1 -0.3 -0.8 -0.7 0.3 0.2 -0.9 -0.6 -0.3 0.8 0.2 -0.5 0.2 0.9
Neuroticism (Nagel 2018) 0.8 1.9 6.2 -2.0 -0.3 1.3 2.5 1.5 1.2 -1.5 1.7 -0.8 0.0 1.3 0.4 0.6 -1.9 1.9 2.5 2.5 1.6 1.1 1.1 0.4 -0.4 0.6 0.8 -0.4 -1.8 -0.3 0.1 -1.2 -1.3
Schizophrenia (2018) 0.8 1.8 4.4 1.4 1.6 1.1 1.4 0.8 1.0 -0.1 1.0 -0.8 0.0 1.1 -2.0 2.1 0.3 1.9 1.4 2.0 1.7 1.5 1.0 1.9 2.1 0.3 0.2 1.4 -2.0 0.4 -1.5 -0.4 0.3
Schizophrenia vs Biploar Disorder 1.6 2.1 5.0 1.3 1.5 2.0 2.0 1.4 0.8 0.0 1.4 -0.4 0.0 2.0 -1.2 1.8 1.2 2.1 2.2 1.8 1.9 0.9 2.0 1.8 1.4 1.2 1.4 1.4 -1.0 1.4 0.5 0.7 0.5
Worry (Nagel 2018) 2.3 4.9 14.7 -1.3 1.1 2.4 3.8 2.6 1.9 -1.5 2.5 -1.7 0.0 2.4 -1.3 2.2 -2.4 3.5 3.7 3.2 3.1 0.8 2.8 2.0 1.3 2.3 2.2 1.2 -3.3 0.7 -0.1 -0.6 -1.0
Alzheimer’s Disease (in mother) 0.3 0.4 1.7 -0.3 -0.4 -0.3 -0.2 -1.3 -0.3 1.0 0.3 -0.6 0.0 -0.3 0.4 -1.0 -0.0 -0.4 -1.2 -1.1 -0.0 0.3 0.1 -0.8 -0.5 0.5 0.6 -0.3 0.6 0.3 -0.3 0.3 -1.0
Alzheimer’s Disease (in father) 0.7 0.7 2.2 0.6 1.1 0.6 0.8 -1.1 0.9 1.5 1.1 -0.9 0.0 0.6 -1.2 0.6 1.4 0.9 0.4 -0.0 1.0 -0.0 1.0 0.7 1.1 0.8 0.9 0.8 -0.6 0.7 -0.3 0.9 0.5
Alzheimer’s Disease (including proxy) 0.4 0.6 3.0 0.2 0.6 0.4 0.5 -1.7 0.1 1.7 1.0 -0.9 0.0 0.4 -0.6 -0.4 0.5 0.5 -0.5 -0.8 1.0 0.5 0.7 -0.0 0.8 0.7 1.2 0.4 -0.2 0.7 -0.7 0.7 -0.6
Crohns Disease (2017) 0.3 0.7 5.7 -0.2 -0.2 -0.6 -0.8 -1.1 -0.6 0.2 -0.6 0.1 0.0 -0.6 -0.1 -0.5 -0.4 -0.5 -0.9 -0.7 -0.4 -2.4 -1.4 -0.4 0.1 -1.5 -1.3 -0.9 -0.2 -1.1 -1.4 -0.8 0.1
Irritable Bowel Disease (IBD) 0.5 1.2 6.2 0.2 -0.4 -0.6 -0.7 -0.6 -1.2 0.2 -0.8 0.2 0.0 -0.6 -0.1 -0.6 -1.0 -0.4 -0.8 -1.2 -0.3 -2.1 -1.6 -0.5 0.2 -2.1 -1.9 -1.4 -0.4 -1.5 -2.5 -1.6 -0.2
Ulcerative Colitis (UC) 0.5 0.8 5.2 1.0 -0.0 -0.1 -0.5 -0.4 -1.2 1.0 -0.5 0.1 0.0 -0.1 -0.2 -0.5 -1.0 -0.2 -0.9 -1.4 -0.2 -1.4 -1.2 -0.3 0.3 -1.6 -1.6 -1.0 0.1 -0.8 -2.3 -1.3 0.1
Major Depression (MDD) 1.9 2.3 4.7 1.0 1.8 2.1 1.6 0.6 2.1 1.2 1.3 -0.0 0.0 2.1 -1.2 1.6 1.7 1.8 1.3 2.2 1.8 1.6 1.7 1.6 1.2 1.7 1.9 1.8 0.1 1.6 0.9 2.0 0.9
Reaction Time 3.4 6.5 20.5 1.2 -2.0 -2.1 -3.8 -2.2 -2.2 1.9 -2.9 0.9 0.0 -2.1 2.7 -3.2 0.9 -3.5 -4.0 -3.8 -4.3 -1.8 -2.7 -3.2 -2.6 -0.1 -1.5 -1.9 4.5 1.0 2.7 0.8 1.5
Verbal and Numeric Reasoning (VNR) 0.3 0.7 3.7 1.8 1.0 0.1 -0.8 -0.2 -0.8 1.8 -1.0 -0.6 0.0 0.1 -0.9 0.2 1.3 -0.3 -1.2 -0.4 -0.3 -1.9 -0.4 0.4 0.7 0.0 0.2 0.0 0.8 0.7 -0.7 0.7 0.8
Breast Cancer 1.2 2.8 9.0 0.9 -1.1 -1.4 -2.5 -0.8 -2.5 1.2 -1.8 0.7 0.0 -1.4 1.3 -2.0 0.6 -2.2 -2.5 -3.0 -2.2 -1.6 -2.6 -1.9 -1.1 -1.7 -2.0 -1.5 2.2 -0.5 -0.0 -0.2 0.6
Ovarian Cancer 1.4 1.8 4.9 0.2 -1.4 -1.5 -2.0 -1.4 -1.3 -0.3 -2.2 0.3 0.0 -1.5 1.5 -1.6 -0.7 -2.1 -1.6 -1.1 -2.0 0.8 -2.0 -1.7 -1.5 -1.3 -1.2 -0.8 1.8 -0.8 1.0 0.0 0.3
Prostate Cancer 0.7 1.0 2.6 -0.9 -1.6 -1.0 -0.5 -0.1 -0.3 -1.3 -0.9 -1.2 0.0 -1.0 1.4 -1.0 -1.3 -0.9 -0.1 0.4 -1.2 1.3 -0.7 -1.3 -1.4 -0.9 -1.0 -0.9 -0.1 -1.1 0.5 -1.3 -0.5
Age at First Birth 0.7 1.0 3.7 1.1 1.4 0.6 -0.0 0.5 0.4 1.8 1.0 0.8 0.0 0.6 -1.4 1.0 1.9 0.6 -0.5 -0.2 0.2 0.6 0.9 1.0 1.5 0.9 1.2 1.4 -0.0 1.1 -0.6 1.2 0.9
Bipolar Disorder (2011) 1.7 1.7 3.6 -0.2 -1.4 -1.6 -1.3 -1.6 -1.8 -0.5 -1.2 0.0 0.0 -1.6 0.9 -1.2 -1.5 -1.4 -1.6 -1.3 -1.3 -0.2 -1.8 -1.3 -0.9 -1.7 -1.9 -1.7 -0.2 -1.4 -1.0 -1.6 -1.1
Body Mass Index (BMI) (2010) 2.6 3.6 10.0 -1.9 -2.9 -1.5 -1.1 -0.5 -2.1 -1.4 -1.8 0.5 0.0 -1.5 3.1 -2.8 -0.7 -2.0 -1.6 -0.8 -2.2 -0.6 -2.0 -2.9 -3.2 -1.9 -2.0 -3.0 1.3 -1.8 0.4 -2.0 -1.2
Coronary Artery Disease (CAD) 0.4 0.5 3.2 -0.8 -0.7 -0.3 0.5 0.2 0.2 -1.4 -0.3 0.9 0.0 -0.3 0.5 -0.1 -0.8 0.1 0.7 1.0 0.6 -0.7 0.6 -0.2 -0.5 -0.3 0.5 -0.5 -1.1 -1.1 -0.6 -0.8 -1.8
Crohns Disease (2012) 0.6 1.0 3.9 -0.3 -0.6 -0.8 -1.3 -1.1 0.3 -0.5 -2.0 0.0 0.0 -0.8 0.5 -0.6 0.2 -1.0 -0.9 -0.6 -1.2 -1.8 -1.5 -0.6 -0.4 -1.8 -2.0 -0.8 0.5 -1.0 -0.5 -0.9 0.8
Mean Putamen Volume 6.7 7.7 16.9 1.2 3.2 4.1 2.9 3.0 3.9 2.0 3.0 2.3 0.0 4.1 -2.1 3.1 2.8 3.6 2.8 3.4 2.1 -1.0 3.2 3.2 1.9 2.9 2.2 2.2 0.3 3.5 2.2 2.5 3.2
Fasting Glucose 0.6 0.7 2.7 1.6 1.4 0.5 0.3 0.2 0.3 0.1 -0.2 0.1 0.0 0.5 -1.6 1.6 -0.7 0.9 0.7 0.4 0.7 0.1 -0.1 1.6 1.6 0.3 -0.5 1.2 -0.8 0.5 -0.7 -0.2 1.1
HbA1C 3.7 4.1 9.6 -1.1 -2.0 -1.9 -3.0 -2.3 -1.4 0.4 -2.8 -0.6 0.0 -1.9 2.1 -2.7 -0.5 -2.9 -3.1 -2.7 -3.1 -0.3 -2.6 -2.6 -2.3 -2.0 -2.3 -1.7 2.4 -1.2 0.2 -1.0 -0.4
HDL Cholesterol 0.9 1.5 4.1 -1.1 -1.8 -0.9 0.1 0.2 -1.5 -1.3 -0.0 -1.2 0.0 -0.9 1.7 -1.5 -1.3 -0.5 0.1 -0.0 -0.7 -1.0 -0.8 -1.3 -1.8 -1.6 -1.4 -2.0 -0.5 -1.8 -0.6 -2.0 -1.7
LDL Cholesterol 2.6 4.1 13.4 -1.0 -2.0 -2.5 -1.1 -1.2 -2.9 -2.5 -1.6 -1.0 0.0 -2.5 0.5 -0.7 -2.4 -1.3 -1.1 -1.2 -0.4 -0.4 -2.0 -1.2 -0.6 -2.9 -2.3 -1.7 -2.2 -3.3 -3.7 -3.4 -3.1
Lupus 10.9 16.5 31.7 2.4 5.6 4.6 4.1 1.7 4.5 2.8 3.9 0.3 0.0 4.6 -5.1 5.0 2.4 5.0 3.7 3.3 4.8 2.8 5.2 5.1 5.0 5.2 5.3 5.6 -2.0 4.7 1.0 4.1 2.6
Neuroticism (2016) 0.5 0.8 3.4 -0.4 0.5 1.2 1.6 0.9 0.2 -0.0 1.9 -0.2 0.0 1.2 -0.4 0.6 0.2 1.4 1.7 1.6 1.5 -0.1 0.2 0.6 0.4 -0.1 0.2 0.1 -1.1 -0.2 -0.4 -0.6 0.1
Primary Biliary Cirrhosis 1.4 2.0 6.5 1.2 1.3 -0.5 0.5 -0.8 1.3 -1.4 -0.2 -0.7 0.0 -0.5 -2.5 2.5 -0.4 0.8 1.2 0.8 1.8 1.6 1.2 2.0 2.5 0.9 1.3 2.3 -2.5 0.0 -1.6 0.5 -0.5
Rheumatoid Arthritis 1.2 1.7 9.7 -1.2 -0.8 0.3 1.6 1.0 1.6 -3.1 0.8 -1.4 0.0 0.3 0.8 0.1 -0.9 0.8 2.3 2.5 1.0 2.2 1.3 0.1 -0.8 0.2 0.8 0.2 -1.5 -0.9 0.9 -0.6 -1.6
Schizophrenia (2014) 1.0 2.2 6.9 1.9 1.9 0.9 1.3 1.0 0.6 -0.1 0.7 -0.4 0.0 0.9 -2.5 2.4 0.2 1.9 1.4 1.9 1.9 1.5 1.1 2.3 2.6 0.1 0.2 1.8 -2.3 0.5 -2.0 -0.5 0.2
Triglycerides 0.2 0.3 1.4 1.2 0.5 -0.3 -0.9 -0.5 0.2 -0.5 -0.7 0.3 0.0 -0.3 -0.6 0.6 -0.0 -0.2 -0.5 -0.6 -0.2 1.2 -0.6 0.5 0.7 -0.3 -0.4 0.5 0.1 0.2 -0.3 -0.1 0.2
Type 2 Diabetes (T2D) (2012) 0.9 1.1 9.1 0.9 0.8 -0.6 -0.0 -0.9 -0.2 -0.1 0.4 -2.0 0.0 -0.6 -1.7 0.7 -0.7 0.3 -0.1 -0.2 0.7 -0.6 0.1 1.0 1.3 -0.8 -0.2 0.1 -2.0 -0.9 -3.0 -0.6 -1.2
Ulcerative Colitis 0.4 0.6 3.0 1.0 0.8 0.5 0.5 0.1 0.1 -0.3 -0.4 -0.7 0.0 0.5 -1.1 0.9 -1.3 0.8 0.7 0.3 0.9 0.4 -0.0 1.1 1.3 -0.8 -0.7 0.2 -1.1 -0.3 -1.7 -0.9 0.3
Blood Eosinophil Count 0.6 4.3 15.3 3.1 2.8 0.4 0.9 0.9 2.1 0.0 0.2 -1.5 0.0 0.4 -3.9 3.2 -0.5 1.5 1.0 -0.1 2.5 1.8 1.9 3.0 3.9 2.3 2.5 3.4 -2.4 1.6 -1.7 1.4 -0.2
Blood Platelet Count 3.5 40.9 153.8 -12.4 -5.1 4.2 10.8 7.1 4.0 -9.8 6.5 -0.2 0.0 4.2 5.9 -0.6 -7.7 5.8 9.4 10.5 5.9 5.8 5.8 -1.2 -6.0 1.7 3.5 -3.5 -7.4 -4.6 1.6 -6.1 -9.1
Blood Red Count 4.5 43.0 102.0 6.5 10.1 6.9 4.9 3.0 7.1 4.2 6.4 -0.6 0.0 6.9 -9.7 9.4 4.7 7.6 5.6 3.5 6.6 2.7 7.5 9.6 9.6 6.3 6.0 9.6 -2.7 7.5 0.4 6.4 6.5
Blood White Count 0.1 0.5 1.5 -0.9 -0.4 0.4 1.2 -0.6 -0.9 -0.9 0.7 -0.7 0.0 0.4 0.3 -0.1 -1.1 0.7 0.3 -0.3 1.2 -1.2 -0.3 -0.1 -0.3 -0.1 0.1 -0.5 -1.1 -0.8 -1.0 -0.7 -1.1
Heel T-Score 0.4 3.4 21.6 -1.7 -0.7 2.0 0.5 2.3 1.6 0.5 1.5 -0.8 0.0 2.0 2.5 -1.1 2.4 0.6 0.7 1.4 -2.3 2.5 0.7 -1.1 -2.4 0.7 -1.0 -0.9 2.6 1.6 4.7 0.0 3.2
BMI 1.3 7.5 18.1 -2.9 -4.2 -2.4 -1.8 -1.3 -2.9 -2.4 -2.0 -1.4 0.0 -2.4 4.1 -3.4 -2.2 -2.7 -1.9 -1.4 -3.2 -1.3 -2.6 -3.8 -4.2 -3.0 -3.3 -4.2 1.0 -3.0 -0.1 -3.6 -2.5
Height 0.4 8.5 36.2 5.6 5.0 0.7 -0.4 1.6 -1.1 2.3 1.5 -0.3 0.0 0.7 -6.0 4.8 3.4 1.8 0.5 -0.2 2.2 -2.6 -0.0 4.8 5.5 -0.4 0.2 3.6 -1.6 1.6 -3.5 2.0 3.5
Waist Hip Ratio (WHR) 0.6 2.8 11.8 1.4 1.4 -0.1 1.6 1.0 1.6 -0.6 1.5 1.4 0.0 -0.1 -2.5 2.2 -0.5 1.6 1.4 0.7 2.4 0.2 2.2 2.2 2.5 1.1 2.1 2.0 -3.4 0.4 -2.1 -0.6 -1.8
Systolic Blood Pressure 0.8 3.9 11.4 -1.3 -3.3 -2.1 -1.2 -2.3 -1.4 -2.5 -1.4 0.1 0.0 -2.1 3.1 -2.6 -2.1 -2.4 -1.2 -0.7 -1.7 0.4 -2.0 -2.9 -3.4 -1.5 -0.9 -2.2 0.6 -2.5 0.6 -1.5 -2.2
Smoking Status 0.7 1.7 5.2 -0.9 0.4 0.8 2.0 1.4 0.9 -1.0 0.6 -0.4 0.0 0.8 -0.7 1.1 -0.9 1.4 1.7 2.2 2.3 2.2 1.6 1.0 0.8 0.9 1.7 0.9 -2.2 -0.1 -1.0 -0.4 -1.7
Allergy or Eczema 0.3 0.8 4.2 -0.7 -0.2 -0.1 0.9 1.2 0.3 -2.0 0.7 1.0 0.0 -0.1 -0.1 0.5 -1.9 0.5 1.3 1.5 0.9 -0.5 0.3 0.5 0.2 -0.2 0.5 -0.1 -1.5 -1.1 -0.7 -0.8 -1.1
Cardiovascular Disease 0.6 2.1 9.4 -2.1 -2.2 -1.1 0.3 0.8 -1.0 -2.8 -0.3 0.0 0.0 -1.1 1.7 -1.0 -3.1 -0.5 0.1 0.5 -0.5 0.9 -0.4 -1.3 -1.8 -1.0 -0.7 -1.5 -1.4 -2.1 -0.3 -2.3 -2.6
Hypothyroidism (self reported) 5.7 13.1 23.8 0.9 4.1 3.5 4.0 2.7 4.5 -0.8 3.9 -1.1 0.0 3.5 -4.2 4.9 0.4 4.4 4.8 4.7 4.5 3.8 4.8 4.8 4.3 3.9 4.3 4.8 -3.4 3.0 0.6 2.3 1.1
Respiratory disease 0.2 0.5 2.5 0.0 -0.7 -0.2 -0.4 -0.3 -0.3 -0.4 -0.6 0.4 0.0 -0.2 0.7 -1.0 -0.1 -0.3 -0.8 0.1 -0.7 -0.4 -1.2 -0.8 -0.7 -1.1 -1.2 -1.6 0.2 -1.2 -0.8 -0.9 -0.1
Type 2 Diabetes (T2D) (2018) 1.5 2.8 10.3 2.1 2.5 0.7 0.8 1.4 1.8 -0.3 0.2 0.1 0.0 0.7 -3.2 3.0 -0.2 1.5 1.3 1.2 2.0 1.1 1.5 2.8 3.0 0.9 1.2 2.9 -2.0 1.0 -1.4 1.1 0.2
Lung FEV1/FVC ratio 1.3 6.7 14.6 -2.2 -3.5 -3.2 -2.4 -0.2 -2.2 -2.0 -2.9 0.5 0.0 -3.2 2.6 -2.4 -1.6 -2.9 -2.2 -2.1 -3.1 -3.7 -2.4 -3.0 -2.9 -2.8 -3.3 -3.5 -0.2 -2.7 -1.6 -3.8 -2.4
Lung FVC 0.4 2.0 10.4 -1.5 -1.5 0.4 -0.4 1.3 0.2 -1.2 -0.4 1.2 0.0 0.4 2.7 -1.6 0.2 -0.8 0.3 0.4 -1.8 -1.9 -0.9 -1.5 -2.6 -0.3 -1.3 -1.7 2.5 0.0 3.2 0.2 1.4
Neuroticism 0.5 1.3 4.5 -1.2 -0.2 1.1 2.1 1.3 1.0 -1.3 1.4 -0.6 0.0 1.1 0.1 0.8 -1.6 1.7 2.0 1.9 1.3 0.9 0.8 0.5 -0.2 0.4 0.5 -0.4 -1.9 -0.2 -0.4 -1.3 -1.0
Chronotype (morning person) 1.1 2.4 10.0 1.1 -0.4 -1.5 -2.5 -1.0 -2.6 0.9 -2.0 -1.5 0.0 -1.5 0.3 -1.2 0.6 -1.9 -2.6 -3.2 -2.1 -1.5 -2.2 -1.0 -0.4 -1.5 -2.1 -1.0 1.5 -0.3 -0.7 -0.5 0.7
Hair Pigment 0.1 3.6 9.0 0.9 2.4 0.5 1.5 0.3 1.8 0.3 1.8 1.3 0.0 0.5 -2.8 2.7 0.5 1.6 1.4 2.1 2.8 -0.3 3.0 2.5 3.0 2.3 2.7 2.3 -1.6 2.0 -0.9 2.4 -0.2
Tanning 0.2 2.0 6.1 -1.2 -1.6 0.0 -0.9 0.9 -1.1 0.5 -1.0 -1.8 0.0 0.0 2.4 -2.2 0.4 -1.1 -0.9 -0.6 -2.3 -0.5 -1.6 -2.2 -2.5 -1.0 -1.5 -1.7 2.2 -0.2 2.0 -0.5 1.1
Hand grip strength (left) 1.0 2.7 13.8 0.5 1.5 2.0 1.3 1.5 1.4 1.5 2.2 0.6 0.0 2.0 -0.7 1.2 2.4 1.5 1.1 0.8 0.7 -3.7 1.8 1.2 0.6 2.2 1.9 0.7 0.6 2.2 2.0 1.9 2.1
Number of treatments/medications taken 0.6 1.0 6.0 -2.5 -1.2 -0.4 0.5 -0.0 0.2 -2.0 -0.5 0.9 0.0 -0.4 1.0 -0.8 -2.0 -0.2 0.3 0.4 0.3 0.8 -0.4 -0.9 -1.1 -0.8 -0.2 -0.9 -0.8 -1.8 -0.5 -1.0 -1.6
Average weekly spirits intake 1.9 2.3 4.5 -1.1 -1.7 -1.9 -1.7 -1.3 -1.4 0.2 -1.8 2.0 0.0 -1.9 1.4 -2.1 -1.7 -1.8 -2.1 -1.2 -1.8 -0.2 -1.6 -2.1 -1.3 -1.2 -1.6 -1.8 0.5 -1.1 -0.9 -1.8 -1.3
Sensitivity / hurt feelings 1.1 1.9 5.2 -1.9 -2.0 -1.3 -0.7 -0.4 -1.6 -0.3 -0.9 -1.1 0.0 -1.3 1.7 -1.8 -1.5 -1.2 -1.3 -0.4 -0.8 -0.5 -1.7 -1.8 -1.6 -1.5 -1.1 -2.3 0.1 -1.6 -1.1 -1.7 -1.8
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.4 0.4 0.3 -0.2 -0.5 0.1 0.7 0.7 -0.3 -1.0 0.0 -0.2 -0.3 0.0 0.2 -0.3 -0.7 -0.2 -0.3 1.2 0.2 -0.1 0.2 0.5 0.3 0.5 0.7 0.8 0.4 0.7 0.4
Hearing difficulty/problems: Yes 0.4 0.6 2.5 0.5 0.8 1.0 0.6 1.4 -0.2 -0.2 1.4 -1.6 0.0 1.0 -0.6 1.0 -0.8 0.9 1.2 0.6 0.5 0.3 0.0 1.0 0.7 0.0 -0.5 0.7 -0.1 0.5 0.3 -0.1 0.9
Relative age of first facial hair 0.6 1.3 6.9 -0.6 0.0 0.0 1.4 0.2 0.6 -2.6 0.9 -0.2 0.0 0.0 -0.6 1.5 -0.9 0.8 1.9 1.1 1.9 0.4 1.3 1.2 0.6 0.2 1.1 0.8 -2.3 -1.0 -0.8 -0.3 -2.1
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 3.6 0.6 1.3 0.4 -0.0 -0.4 0.4 1.3 -0.5 0.3 0.0 0.4 -1.5 1.0 -0.7 0.6 -0.2 -0.7 0.5 1.9 0.1 1.1 1.6 0.7 0.2 1.0 -0.1 1.1 -0.4 0.9 1.1
Ever used hormone-replacement therapy (HRT) 1.5 1.9 5.9 -2.3 -0.0 2.2 2.0 2.0 2.0 -0.4 2.1 -0.2 0.0 2.2 1.1 0.2 -0.6 1.6 1.8 1.8 0.4 2.4 1.3 0.2 -1.0 0.9 -0.2 -0.2 0.1 0.4 1.8 -0.7 0.7
Ever had hysterectomy (womb removed) 0.9 1.0 4.2 -0.6 0.1 0.2 1.3 1.7 0.5 -1.7 0.9 0.1 0.0 0.2 -0.5 0.9 -1.5 0.9 1.7 1.0 1.4 1.0 1.1 0.9 0.5 0.6 0.8 0.6 -2.0 -0.3 -0.3 -0.7 -1.7
Systolic blood pressure, automated reading 0.7 2.0 5.5 -1.6 -2.2 -1.1 -0.5 -2.0 -0.5 -2.1 -0.3 -0.6 0.0 -1.1 2.1 -1.6 -2.0 -1.4 -0.4 0.3 -0.7 2.3 -1.1 -1.9 -2.2 -0.9 -0.6 -1.2 0.3 -2.0 0.3 -0.8 -1.7
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 2.8 0.3 -0.3 0.2 0.5 -0.0 0.3 -1.7 0.0 -0.3 0.0 0.2 0.2 0.4 -0.7 0.2 1.0 1.0 0.5 0.1 -0.4 0.3 -0.3 -1.1 -0.8 -0.1 -0.8 -1.3 -0.2 -0.7 -0.5
Angina 1.0 1.3 4.0 -1.6 -1.7 -1.0 -1.1 0.2 -0.4 -0.2 -1.6 0.7 0.0 -1.0 2.0 -1.4 0.1 -1.7 -1.2 -0.4 -1.4 -1.0 -0.5 -1.8 -2.0 -0.6 -0.5 -1.2 1.7 -0.5 1.4 0.0 -0.7
Medication for hormone replacement therapy 0.5 0.6 1.4 0.3 0.8 0.6 0.7 1.2 1.2 0.1 0.9 -0.3 0.0 0.6 -0.8 0.8 -0.2 0.9 0.8 0.9 0.9 1.1 1.0 0.8 1.1 0.9 0.7 0.9 -0.8 0.5 -0.1 -0.1 -0.1
Vitamin and mineral supplements 0.8 1.1 4.7 -0.1 0.7 1.7 1.5 2.2 0.9 0.6 1.2 0.9 0.0 1.7 -0.1 1.0 0.1 1.6 1.6 1.1 0.5 0.4 1.0 0.8 0.0 1.0 0.3 0.4 -0.2 1.3 1.2 -0.1 1.2
Supplements: Zinc 1.1 1.2 2.9 -0.2 -0.8 -1.5 -1.2 -0.7 -1.1 -0.2 -1.4 1.7 0.0 -1.5 0.3 -1.3 -1.0 -1.3 -1.5 -1.2 -0.7 -0.4 -1.4 -1.1 -0.3 -1.5 -1.3 -1.0 -0.1 -1.1 -1.7 -1.2 -1.2
Medication: Co-codamol 0.3 0.4 2.9 -0.4 -0.3 0.2 0.1 0.6 1.1 -0.8 -0.5 1.7 0.0 0.2 0.5 0.0 0.3 0.1 0.8 0.6 -0.4 1.4 -0.2 -0.1 -0.6 -0.3 -0.8 0.1 0.2 -0.0 0.7 -0.6 0.4
Medication: Metformin 1.5 2.1 6.6 2.0 2.4 1.2 0.1 0.7 1.3 1.3 0.2 1.3 0.0 1.2 -2.2 1.9 1.4 1.0 0.7 0.4 0.6 1.2 1.0 2.0 2.0 1.2 0.7 2.6 0.4 2.1 0.6 1.8 2.2
Diabetes (father) 0.4 0.5 9.0 0.0 0.1 -0.4 -0.0 0.3 0.9 -0.9 -0.5 -0.5 0.0 -0.4 -0.5 0.6 -0.2 -0.0 0.6 0.2 -0.0 3.0 0.9 0.4 0.3 0.5 0.3 0.8 -0.7 0.5 0.3 -0.2 -0.6
Diabetes (mother) 1.3 1.7 6.4 0.4 0.9 1.8 1.8 2.0 1.8 -1.7 0.1 0.1 0.0 1.8 -0.8 1.6 -0.4 2.1 2.5 1.5 1.1 -0.6 0.3 1.7 0.8 -0.3 -0.8 0.3 -1.9 0.1 -0.3 -1.7 0.5
Severe depression (siblings) 1.7 1.9 5.0 0.2 1.5 2.1 1.3 0.9 2.1 1.2 1.8 1.6 0.0 2.1 -1.0 1.3 1.1 1.8 1.8 1.5 0.9 1.9 0.9 1.3 1.0 0.6 0.4 1.3 -0.0 1.3 1.1 0.7 2.2
Pack years adult smoking proportion 0.8 1.3 4.2 -0.1 0.4 0.5 1.2 2.0 1.3 -1.9 1.1 1.0 0.0 0.5 -0.5 1.6 -0.8 1.0 1.9 1.9 1.0 0.6 1.7 1.4 0.5 1.0 1.3 1.2 -1.1 0.4 1.1 0.4 -0.1
Impedance of leg (right) 0.7 3.4 10.0 1.4 1.8 0.7 2.0 1.7 1.2 -0.9 2.2 -0.2 0.0 0.7 -2.7 2.6 0.0 2.1 1.8 1.6 2.8 1.2 2.5 2.4 2.8 1.9 2.5 2.2 -3.2 0.9 -1.7 0.5 -1.0
Leg fat-free mass (left) 0.3 1.6 6.3 0.2 -1.0 -0.9 -1.3 -0.5 -2.3 -0.3 -1.2 -0.7 0.0 -0.9 1.0 -0.9 -0.3 -1.1 -0.9 -0.9 -1.9 -2.5 -1.9 -1.0 -1.3 -1.9 -2.4 -1.7 0.7 -0.9 -0.2 -1.7 0.5
Trunk fat percentage 0.8 3.2 8.7 -1.0 -2.6 -1.7 -1.0 -0.7 -2.3 -1.6 -1.1 -1.0 0.0 -1.7 2.1 -2.0 -1.9 -1.5 -0.9 -0.9 -1.9 -1.8 -1.9 -2.3 -2.4 -2.1 -2.4 -2.6 -0.2 -2.0 -0.6 -2.9 -1.7
Hand grip strength (right) 0.2 0.7 5.4 0.0 0.2 0.8 1.1 1.4 0.5 -0.1 1.0 0.4 0.0 0.8 -0.0 0.6 0.5 0.8 0.9 1.0 0.7 -2.3 0.9 0.5 -0.1 0.9 1.4 -0.1 -0.5 0.3 0.8 0.4 0.1
Townsend deprivation index at recruitment 0.7 0.9 5.4 1.4 0.7 0.9 0.4 2.3 0.5 -0.6 0.7 0.4 0.0 0.9 -0.3 1.2 1.2 0.7 1.0 0.5 0.0 1.6 0.3 1.1 0.3 0.0 -0.4 0.9 0.5 0.8 1.5 0.7 1.9
Current tobacco smoking 0.6 0.9 4.1 -0.7 -0.1 0.7 1.4 1.1 0.8 -1.2 0.6 0.9 0.0 0.7 0.2 0.6 -1.4 0.9 1.4 1.7 1.1 2.0 1.1 0.5 -0.1 0.9 1.0 0.5 -1.2 0.2 0.2 -0.7 -1.2
Average weekly fortified wine intake 0.6 0.7 4.2 1.3 1.2 0.3 -0.5 -0.3 -0.1 2.1 0.4 -0.1 0.0 0.3 -1.1 0.5 0.6 0.2 -0.8 -0.7 -0.3 0.4 0.1 0.8 0.9 0.7 0.3 0.9 0.9 1.4 0.1 1.2 1.5
Maternal smoking around birth 0.3 0.5 2.2 0.1 0.5 0.4 0.4 0.2 1.0 0.5 1.1 0.6 0.0 0.4 -0.5 0.4 0.8 0.5 0.5 0.6 0.1 0.4 1.1 0.3 0.5 1.2 0.7 0.7 0.0 1.5 1.0 0.5 0.7
Fed-up feelings 0.6 1.0 3.4 -0.9 0.2 1.1 1.4 0.5 1.7 -0.7 1.4 0.9 0.0 1.1 0.1 0.3 -0.1 1.2 1.5 1.5 0.6 -0.1 1.7 0.1 -0.0 1.5 1.5 0.6 -0.4 0.8 1.8 0.5 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.8 0.7 0.5 0.2 -0.3 -0.9 1.0 1.3 -0.4 -0.4 0.0 0.2 -0.3 -0.1 1.2 0.0 -0.5 -0.7 -0.2 0.6 0.1 -0.2 0.3 0.3 0.3 0.6 0.9 0.8 0.5 1.0 1.1
Relative age voice broke 1.2 1.9 9.2 -0.4 0.2 -0.6 1.2 0.4 0.6 -3.0 0.6 -0.0 0.0 -0.6 -1.3 1.8 -2.0 0.8 2.0 0.9 2.0 0.4 1.5 1.5 1.4 0.6 1.2 1.1 -3.0 -0.7 -1.3 -0.5 -2.3
Taking other prescription medications 1.4 2.1 5.6 -2.0 0.4 2.2 2.3 1.7 2.3 0.0 2.4 1.2 0.0 2.2 0.4 0.4 -0.2 2.0 1.9 2.2 0.9 0.2 1.6 0.4 -0.5 1.5 1.2 0.1 -0.0 0.9 2.2 0.9 1.1
Age when periods started (menarche) 2.1 5.1 13.2 3.0 3.6 2.9 1.4 0.8 1.6 3.2 1.7 0.0 0.0 2.9 -3.1 2.6 2.1 2.7 1.5 0.6 1.4 -0.7 1.8 3.0 2.9 2.3 1.2 2.8 0.1 3.3 0.6 2.2 3.5
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 1.5 0.3 0.4 0.9 0.3 -0.1 0.6 1.2 0.3 0.2 0.0 0.9 0.1 0.2 0.3 0.5 0.3 -0.2 -0.1 -0.9 0.1 0.2 -0.0 0.2 -0.2 -0.1 0.4 0.3 0.6 0.1 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 2.0 -0.4 0.8 1.2 1.0 1.1 1.3 -0.2 1.2 0.8 0.0 1.2 -0.7 1.0 0.5 1.4 1.2 1.4 0.5 0.8 1.1 0.9 0.6 0.8 0.4 0.6 -0.9 0.7 0.1 -0.4 0.8
Tinnitus: Yes, but not now, but have in the past 3.3 3.5 9.1 0.1 2.4 2.0 1.9 0.5 2.7 1.4 3.0 0.3 0.0 2.0 -2.1 2.0 1.4 2.2 1.3 1.9 2.2 1.6 2.4 2.2 2.1 2.0 2.7 2.5 -0.6 1.8 0.4 2.1 0.8
Qualifications: CSEs or equivalent 1.3 1.7 5.7 -1.2 0.7 1.6 2.3 1.7 1.1 -0.4 2.1 0.6 0.0 1.6 -0.6 1.0 -0.5 2.1 2.1 2.4 1.7 -0.3 1.8 1.1 0.7 1.1 1.0 0.5 -1.7 0.4 -0.2 -0.4 -0.3
Serious illness, injury or assault to yourself 0.5 0.7 2.4 -0.1 0.6 0.9 0.9 0.4 1.4 0.1 -0.1 0.2 0.0 0.9 -0.4 0.6 0.2 0.9 0.8 0.9 0.7 0.6 1.6 0.6 0.3 1.5 1.2 0.8 -0.0 1.3 1.0 0.8 0.3
High blood pressure 0.5 1.3 4.9 -0.9 -1.6 -0.3 -0.5 0.4 -1.0 -0.9 -0.7 0.6 0.0 -0.3 2.1 -1.7 -0.9 -0.9 -0.7 -0.0 -1.4 1.3 -1.4 -1.6 -2.2 -1.1 -0.8 -1.4 1.2 -1.2 1.4 -0.5 -0.3
Hayfever, allergic rhinitis or eczema 0.2 0.4 2.2 -0.3 -0.2 -0.5 0.3 0.9 0.0 -1.0 0.2 1.5 0.0 -0.5 -0.2 0.3 -1.2 0.0 0.5 0.7 0.7 -0.0 0.4 0.2 0.4 0.1 1.0 0.2 -1.1 -0.6 -0.6 -0.2 -1.1
Multivitamins +/- minerals 1.2 1.5 7.6 1.1 -0.4 -1.3 -2.1 -2.8 -0.7 0.6 -1.2 -0.7 0.0 -1.3 0.4 -1.3 0.7 -1.6 -2.2 -1.7 -1.8 -0.7 -1.5 -1.1 -0.4 -0.7 -0.9 -0.5 1.6 -0.2 0.2 0.6 0.9
Stomach or abdominal pain in last month 4.9 6.1 15.0 -0.6 1.9 2.6 3.8 2.6 2.8 -0.8 3.0 0.6 0.0 2.6 -2.0 3.0 0.6 3.5 3.9 3.2 3.5 2.0 3.7 2.7 1.9 3.0 3.2 2.2 -2.7 1.7 0.6 1.0 0.2
Supplements: Glucosamine 2.5 3.3 8.7 -0.7 -1.7 -2.3 -2.5 -2.6 -2.3 0.6 -2.3 0.3 0.0 -2.3 1.3 -2.8 -0.9 -2.6 -2.9 -2.4 -1.8 -0.7 -2.2 -2.5 -1.3 -1.3 -1.1 -1.6 1.3 -1.3 -1.1 -0.7 -1.2
Diverticular disease/diverticulitis (self-reported) 1.8 2.1 8.1 -0.3 1.2 2.9 2.4 1.7 2.0 0.7 2.3 0.9 0.0 2.9 -0.6 1.3 0.4 2.6 1.9 2.1 1.2 0.1 0.9 1.4 0.5 -0.3 -0.8 -0.1 -0.6 0.5 -0.2 -0.5 1.6
Medication: Atenolol 0.3 0.4 1.6 -1.1 -0.3 0.3 0.4 0.7 0.8 -0.2 0.5 0.4 0.0 0.3 0.5 -0.0 1.1 0.1 0.4 1.2 0.1 0.9 0.6 -0.2 -0.6 0.3 0.6 0.3 0.4 0.2 1.3 0.6 0.0
Medication: Levothyroxine sodium 4.5 7.7 14.7 0.3 3.2 3.5 2.8 2.2 3.4 1.5 2.9 -1.7 0.0 3.5 -2.4 2.5 2.4 3.1 2.8 2.7 2.4 1.7 3.8 2.8 2.4 3.8 3.5 3.2 -0.2 3.7 2.9 3.5 2.8
Sitting height 0.3 2.2 8.3 2.0 1.9 -1.1 -1.6 -0.3 -2.6 1.0 -0.5 -0.1 0.0 -1.1 -2.9 2.0 1.9 -0.5 -0.6 -0.9 0.1 -2.8 -0.3 1.9 2.6 -0.2 0.5 1.4 -0.5 0.7 -2.2 1.1 1.0
Chronic bronchitis/emphysema (father) 1.9 2.2 9.6 0.9 1.4 1.4 0.5 0.6 1.7 1.1 1.3 1.3 0.0 1.4 -0.6 0.8 1.8 0.8 0.8 1.5 0.1 3.1 1.6 1.0 0.6 1.9 1.2 1.8 1.2 2.4 2.5 2.1 2.2
High blood pressure (mother) 2.7 3.8 15.0 -2.2 -2.8 -1.3 -0.1 0.8 -1.9 -3.3 -0.9 -0.3 0.0 -1.3 2.4 -1.0 -2.8 -0.9 0.1 1.1 -0.8 0.1 -1.7 -1.5 -2.5 -2.5 -2.1 -2.6 -1.4 -3.2 -1.6 -3.9 -2.4
Body mass index (BMI) 0.8 3.3 9.1 -1.6 -2.7 -1.4 -1.2 -0.9 -1.4 -1.4 -1.6 -0.2 0.0 -1.4 2.8 -2.5 -2.0 -1.8 -1.2 -1.0 -2.3 -1.1 -1.7 -2.7 -3.0 -1.8 -2.2 -2.6 0.8 -1.8 0.5 -2.4 -1.5
Impedance of leg (left) 0.7 3.2 7.7 1.6 1.9 0.8 1.8 1.6 1.2 -0.3 2.1 0.1 0.0 0.8 -2.7 2.4 0.3 2.0 1.5 1.4 2.7 0.6 2.5 2.4 2.8 2.1 2.7 2.3 -2.7 1.2 -1.4 0.9 -0.7
Leg predicted mass (left) 0.3 1.7 6.6 0.2 -1.1 -0.9 -1.4 -0.5 -2.3 -0.2 -1.2 -0.6 0.0 -0.9 1.1 -0.9 -0.2 -1.2 -0.9 -1.0 -2.0 -2.6 -2.0 -1.1 -1.4 -1.9 -2.4 -1.7 0.9 -0.9 -0.1 -1.6 0.6
Trunk fat mass 0.6 2.6 7.1 -0.6 -2.1 -1.5 -1.1 -0.8 -2.4 -1.4 -1.1 -0.9 0.0 -1.5 1.7 -1.6 -1.5 -1.4 -0.9 -1.0 -1.9 -2.2 -1.8 -1.9 -2.0 -2.0 -2.3 -2.2 -0.1 -1.6 -0.7 -2.7 -1.3
Waist circumference 0.2 0.8 2.7 -0.3 -1.1 -1.1 -0.4 -0.5 -1.0 -1.3 -0.4 0.2 0.0 -1.1 0.6 -0.6 -1.5 -0.7 -0.3 -0.6 -0.8 -1.3 -0.5 -0.8 -0.9 -0.9 -0.7 -0.8 -0.7 -0.9 -0.5 -1.6 -1.4
Number of incorrect matches in round 0.4 0.6 3.2 0.5 -0.0 0.5 -0.4 -0.8 0.4 0.7 0.8 -0.7 0.0 0.5 0.7 -0.7 0.7 -0.2 -0.4 -0.8 -0.9 1.0 -0.4 -0.5 -0.7 0.3 -0.5 0.0 1.8 0.8 1.6 1.0 1.6
Past tobacco smoking 0.2 0.4 2.9 1.7 0.7 0.7 0.1 -0.5 0.6 0.5 0.6 -0.1 0.0 0.7 -0.3 0.4 -0.1 0.5 0.4 0.3 -0.2 -0.4 0.3 0.5 0.3 0.8 0.3 0.7 0.5 1.0 1.2 0.6 1.3
Alcohol usually taken with meals 1.1 1.7 8.1 0.5 -0.3 -1.8 -2.2 -2.8 -1.5 1.7 -1.7 0.5 0.0 -1.8 -0.1 -1.0 0.1 -2.0 -2.4 -2.5 -1.1 -0.4 -1.5 -1.0 0.1 -0.6 -0.3 -0.1 1.3 -0.1 -0.7 0.8 0.1
Nervous feelings 2.2 4.0 12.1 -0.0 1.4 1.3 2.7 2.2 1.1 -1.3 1.3 -3.5 0.0 1.3 -2.1 2.7 -2.4 2.6 2.9 2.0 3.1 0.4 2.2 2.4 2.2 1.6 1.8 1.5 -3.4 0.5 -1.6 -0.7 -1.5
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.7 0.5 -0.0 0.2 0.5 -0.1 0.1 0.3 -0.1 0.4 0.0 0.2 0.0 -0.1 -0.8 0.5 0.5 0.5 0.2 0.8 0.4 -0.2 -0.0 0.6 0.6 0.2 -0.3 0.4 0.7 0.0 -0.0
Hearing difficulty/problems with background noise 0.5 0.7 2.6 -0.5 -0.9 -1.0 -0.6 -0.3 -1.4 -0.8 -0.6 -1.4 0.0 -1.0 0.5 -0.7 -1.2 -0.8 -0.4 -0.5 -0.2 0.3 -1.6 -0.7 -0.4 -1.4 -1.0 -0.9 -0.1 -1.2 -0.9 -0.7 -0.6
Hair/balding pattern: Pattern 2 2.1 2.7 13.0 -0.2 1.0 1.9 1.8 1.4 1.8 1.9 2.6 -0.4 0.0 1.9 -0.3 0.3 0.7 1.6 0.7 0.3 1.0 -1.4 2.5 0.5 0.3 3.6 2.9 1.0 0.5 3.1 2.4 1.7 0.8
Had menopause 0.5 0.6 3.8 0.2 0.5 1.2 0.9 1.9 0.7 0.1 1.0 -1.0 0.0 1.2 -0.1 0.6 -0.2 0.8 0.8 0.9 0.5 0.7 0.9 0.6 0.1 0.7 0.1 0.4 0.2 0.7 0.8 0.4 0.7
Had other major operations 0.3 0.4 3.6 1.9 0.9 0.3 -0.3 0.5 0.2 -0.3 -0.8 0.1 0.0 0.3 -0.7 1.0 0.4 0.1 0.3 0.1 -0.0 0.3 -0.2 0.9 0.6 0.0 -0.2 1.0 0.4 0.2 0.7 1.0 1.2
Forced vital capacity (FVC) 0.2 0.8 8.0 0.1 -0.6 -0.4 -0.9 0.5 -1.1 -0.4 -0.2 1.0 0.0 -0.4 0.8 -0.2 1.1 -0.7 -0.3 0.1 -1.3 -2.8 -0.9 -0.3 -0.9 -0.8 -1.1 -1.1 0.9 -0.1 0.4 -0.4 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.1 1.0 -0.2 0.1 0.3 0.2 0.5 0.5 -0.1 0.2 -0.1 0.0 0.3 -0.1 0.1 -0.6 0.6 0.2 0.5 -0.3 0.2 0.3 0.2 0.1 0.2 -0.3 -0.1 -0.7 0.2 -0.1 -1.0 0.3
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 2.6 0.5 0.9 1.6 1.1 0.3 1.6 0.4 1.2 0.8 0.0 1.6 -0.4 1.0 0.8 1.2 1.1 1.0 1.0 0.9 0.7 1.0 0.3 0.0 0.3 1.0 0.3 0.3 0.6 0.7 0.9
Qualifications: None of the above 0.3 0.7 5.0 -0.3 -0.2 0.3 1.0 1.2 0.9 -1.5 0.7 0.2 0.0 0.3 0.1 0.5 -0.9 0.6 1.2 1.0 0.8 2.2 0.9 0.4 0.0 0.3 0.3 0.7 -0.9 -0.4 0.4 -0.3 -1.0
Financial difficulties in last 2 years 0.6 0.8 3.5 0.1 0.4 0.1 0.9 0.5 1.3 -1.1 -0.0 -0.4 0.0 0.1 -0.8 1.0 -1.2 0.8 1.3 0.8 1.0 1.9 1.1 0.9 0.8 1.0 1.3 1.0 -1.6 0.1 -0.1 -0.2 -0.7
Mouth/teeth dental problems 0.4 0.7 2.3 0.6 -0.1 -0.1 -0.9 -1.3 -0.2 1.5 -0.6 -1.2 0.0 -0.1 0.4 -0.6 0.8 -0.5 -1.2 -0.5 -1.5 -1.5 -0.4 -0.6 -0.4 -0.3 -0.9 -0.7 1.1 0.8 0.8 -0.2 1.2
Heart attack 1.3 1.7 4.6 -0.3 -2.1 -1.9 -1.2 -0.8 -1.3 -1.0 -1.5 1.0 0.0 -1.9 1.8 -1.7 -0.7 -1.9 -1.2 -1.1 -1.3 -1.0 -0.7 -2.0 -1.7 -0.8 -0.4 -1.5 0.4 -1.1 0.3 -0.9 -1.8
Allergy 0.2 0.4 2.1 0.5 0.5 0.6 -0.1 -0.9 -0.1 1.3 0.3 -1.4 0.0 0.6 -0.1 -0.2 1.4 0.1 -0.2 -0.9 -0.5 0.2 -0.0 -0.1 -0.0 0.2 -0.5 0.4 0.8 1.1 0.6 0.2 1.0
Pain all over the body in last month 0.7 0.7 3.1 -0.5 -1.1 -0.2 -0.3 -0.3 -0.1 -1.1 -0.7 0.7 0.0 -0.2 1.3 -0.9 -1.8 -0.4 0.1 0.1 -1.0 1.6 -1.1 -0.8 -1.2 -0.7 -1.3 -0.9 0.3 -0.6 0.6 -1.4 0.1
Diabetes (self-reported) 0.4 0.7 2.7 1.1 1.4 0.4 -0.3 0.0 0.9 0.4 -0.7 1.5 0.0 0.4 -1.4 1.1 0.3 0.4 0.2 0.1 0.2 0.6 0.3 1.1 1.4 0.2 -0.1 1.7 0.0 0.9 0.2 0.9 1.2
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 0.6 -0.4 -0.8 -0.7 -0.1 0.3 -0.0 -0.0 0.3 0.8 0.0 -0.7 0.5 -0.2 -0.7 -0.4 0.1 0.2 -0.3 0.1 0.4 -0.5 -0.4 0.4 0.3 -0.1 -0.4 0.1 0.2 -0.7 -0.5
Medication: Ramipril 1.0 1.3 4.0 -0.0 -1.3 -0.5 -1.0 0.7 -0.6 0.1 -1.8 1.6 0.0 -0.5 1.8 -1.2 0.1 -0.9 -1.0 -0.4 -2.0 -0.6 -1.5 -1.3 -1.7 -1.0 -1.8 -1.4 1.4 -0.3 1.5 -1.1 0.5
Medication: Simvastatin 0.9 1.3 8.0 -0.6 -1.4 -1.0 -0.0 1.2 -0.1 -2.8 -0.6 -0.4 0.0 -1.0 1.0 -0.0 -2.4 -0.6 0.3 0.3 -0.2 0.6 -0.7 -0.4 -0.9 -1.5 -1.1 -0.7 -1.1 -2.0 -0.6 -1.7 -1.8
Fluid intelligence score 0.6 1.3 5.0 0.8 -0.4 -1.2 -1.6 -1.6 -1.5 1.3 -1.5 1.2 0.0 -1.2 0.2 -0.9 0.7 -1.4 -2.2 -1.6 -1.3 -2.2 -1.1 -0.9 -0.3 -0.5 -0.5 -1.0 1.0 0.3 -0.8 -0.3 -0.2
Illnesses of siblings 1.5 2.0 8.2 -0.4 1.6 1.2 0.6 -0.3 1.5 2.4 0.6 1.4 0.0 1.2 -1.2 1.0 1.5 0.9 0.2 0.5 1.1 -0.4 1.7 1.0 1.3 2.3 2.5 1.9 0.8 1.9 1.6 2.9 1.5
Neuroticism score 0.6 1.2 4.7 -0.9 -0.3 0.4 1.4 1.1 0.2 -1.3 0.6 -0.9 0.0 0.4 -0.1 0.8 -2.1 1.2 1.7 1.5 1.2 0.9 0.3 0.5 0.2 -0.5 -0.1 -0.4 -2.2 -1.0 -1.4 -1.9 -1.4
Weight 0.3 1.4 4.9 0.3 -1.1 -1.1 -1.1 -0.5 -1.9 -0.8 -1.0 -0.5 0.0 -1.1 0.9 -0.8 -1.0 -1.0 -0.7 -0.8 -1.7 -2.2 -1.6 -1.0 -1.3 -1.7 -2.0 -1.5 0.2 -1.0 -0.4 -1.9 -0.4
Impedance of arm (right) 0.3 1.4 6.5 -0.3 0.8 0.2 1.5 0.7 0.3 -0.5 1.4 -0.3 0.0 0.2 -1.6 1.5 -0.2 1.4 1.3 1.4 2.0 0.9 1.2 1.3 1.8 1.2 1.5 1.2 -2.5 0.4 -1.5 -0.1 -1.0
Arm fat percentage (right) 0.9 3.5 8.8 -1.9 -3.0 -1.7 -0.7 -0.9 -1.9 -1.8 -1.5 -0.3 0.0 -1.7 2.6 -2.3 -2.5 -1.6 -0.8 -0.7 -1.7 -1.2 -1.7 -2.6 -2.8 -1.8 -1.9 -2.6 -0.2 -2.1 -0.3 -2.9 -2.3
Trunk fat-free mass 0.1 0.8 5.6 1.9 0.8 0.1 -0.9 0.1 -1.1 0.7 -0.3 -0.3 0.0 0.1 -0.8 0.8 1.2 -0.1 -0.4 -0.6 -0.7 -2.4 -0.8 0.7 0.5 -0.8 -1.0 0.1 0.7 0.4 -0.3 0.1 1.6
Hip circumference 0.2 0.9 2.7 -0.3 -0.8 -0.7 -0.4 -0.3 -1.3 -1.0 -0.6 -1.0 0.0 -0.7 0.4 -0.3 -1.2 -0.5 -0.3 -0.1 -0.9 -1.6 -1.0 -0.5 -0.8 -1.5 -1.6 -1.3 -0.5 -1.2 -0.9 -1.6 -0.5
Time employed in main current job 0.5 0.6 3.5 -0.5 -0.1 0.3 -0.1 -1.2 0.3 0.9 0.6 0.5 0.0 0.3 0.7 -0.7 0.5 -0.4 -0.4 -0.5 -0.2 0.2 0.3 -0.7 -0.6 1.1 1.1 0.1 1.5 1.1 1.9 1.5 0.4
Alcohol intake versus 10 years previously 2.4 3.5 10.5 -0.9 1.4 1.8 2.8 2.3 2.5 -0.9 2.3 0.2 0.0 1.8 -1.6 2.0 -0.4 2.7 2.8 3.2 2.2 1.6 3.1 2.0 1.5 1.9 2.0 1.3 -2.5 1.0 -0.1 0.1 -0.5
Father’s age at death 1.1 1.5 3.7 -0.9 -1.0 -1.2 -1.6 -1.7 -0.7 0.8 -1.2 0.9 0.0 -1.2 1.3 -1.9 0.3 -1.9 -1.8 -1.8 -1.2 -1.3 -1.3 -1.7 -1.3 -0.6 -0.2 -1.0 1.9 -0.6 0.1 0.5 -0.6
Worrier / anxious feelings 1.4 2.6 8.6 -0.8 0.9 1.6 2.5 1.9 1.5 -1.2 1.6 -1.4 0.0 1.6 -1.0 2.0 -2.1 2.5 2.9 2.9 2.1 0.9 1.5 1.9 1.1 0.7 0.8 0.6 -2.6 -0.2 -0.6 -1.0 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 3.6 -1.9 0.2 1.2 1.9 1.0 1.9 -0.3 1.0 1.4 0.0 1.2 0.1 0.6 -0.5 1.5 1.6 1.7 0.9 1.7 1.8 0.5 -0.3 1.2 1.5 0.3 -0.8 0.8 1.2 0.1 -0.1
Falls in the last year 0.8 1.0 2.4 -1.2 -1.4 -1.1 -1.1 -0.7 -0.8 -0.0 -0.8 1.4 0.0 -1.1 1.4 -1.5 -0.5 -1.4 -1.1 -1.0 -1.3 0.2 -1.1 -1.6 -1.4 -0.9 -0.6 -1.1 1.1 -0.6 0.8 -0.2 -0.4
Hair/balding pattern: Pattern 3 0.3 0.5 4.0 0.3 0.6 0.8 -0.0 0.4 -0.5 0.8 0.6 2.0 0.0 0.8 -0.0 0.1 1.6 0.4 -0.1 0.3 -0.4 0.4 -0.0 0.2 -0.1 0.1 0.2 0.1 1.1 0.9 0.9 0.8 1.4
Number of live births 0.3 0.4 1.6 -1.3 -0.9 -0.3 0.2 0.3 -0.6 -1.2 0.0 -0.4 0.0 -0.3 1.0 -0.5 -0.0 -0.4 0.3 -0.2 0.2 -0.5 -0.2 -0.4 -0.9 -0.9 -0.2 -1.1 0.1 -1.2 -0.3 -0.3 -1.2
Forced expiratory volume in 1-second (FEV1) 0.6 2.0 14.4 -0.9 -1.7 -1.2 -1.3 0.2 -1.4 -0.9 -0.6 1.3 0.0 -1.2 1.7 -1.1 0.6 -1.4 -0.9 -0.5 -2.1 -3.8 -1.5 -1.4 -1.9 -1.5 -1.9 -2.2 0.9 -0.8 0.0 -1.5 -0.1
Pulse rate 2.6 4.5 15.3 1.5 2.2 2.7 0.9 0.2 2.8 2.6 2.4 -0.6 0.0 2.7 -0.8 0.6 2.4 1.5 1.1 0.6 0.2 0.1 1.6 1.1 0.9 3.2 2.2 2.2 2.1 3.8 3.9 3.1 3.6
Happiness 0.6 0.7 3.4 -0.1 0.3 -0.6 0.3 -0.2 -0.4 -1.2 -0.3 -0.7 0.0 -0.6 -1.2 1.2 -0.4 0.4 0.9 0.6 1.0 0.7 0.5 0.9 1.4 -0.8 -0.1 0.7 -1.9 -0.7 -1.7 -0.8 -1.3
Noisy workplace 0.8 1.0 7.2 -2.7 -1.5 -0.2 0.2 -0.3 -0.2 -0.7 -0.2 -1.1 0.0 -0.2 1.8 -1.6 -0.9 -0.4 -0.1 0.0 -0.7 0.1 -0.4 -1.6 -1.7 -0.5 -0.4 -1.2 0.6 -1.1 1.3 -0.0 0.1
Qualifications: A levels/AS levels or equivalent 2.0 4.5 12.3 -0.0 -1.6 -2.9 -2.2 -2.3 -3.1 -0.4 -2.9 -0.0 0.0 -2.9 0.6 -1.7 -2.3 -2.3 -2.9 -2.5 -1.2 -1.6 -2.7 -1.7 -0.7 -2.6 -1.7 -2.1 -0.3 -3.0 -3.5 -1.9 -2.5
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 2.6 0.1 -0.3 0.1 0.2 -0.2 0.2 0.4 0.8 0.1 0.0 0.1 0.4 -0.2 0.5 0.1 0.0 0.5 -0.2 1.6 -0.1 -0.3 -0.4 0.1 0.2 -0.2 0.4 0.3 0.5 0.3 0.6
Mouth/teeth dental problems: Dentures 0.2 0.4 1.6 0.4 0.3 0.0 0.2 1.2 0.5 -1.2 -0.5 0.5 0.0 0.0 -0.4 0.6 -0.2 0.2 0.7 0.6 0.9 1.0 -0.4 0.6 0.5 -0.9 -0.2 0.6 -0.6 -1.2 -1.0 -0.0 -0.6
Asthma 0.2 0.3 1.4 0.3 -0.4 -0.4 0.0 -0.6 -0.2 -0.5 -1.0 0.9 0.0 -0.4 0.1 -0.4 -0.5 -0.1 -0.4 0.0 0.2 -0.8 -0.5 -0.3 -0.1 -0.6 -0.2 -0.9 -0.5 -1.2 -0.9 -0.4 -0.6
Medication: Ibuprofen (e.g. Nurofen) 1.7 2.2 5.0 -1.0 -2.1 -1.8 -1.3 -1.4 -1.9 -1.3 -1.8 -0.5 0.0 -1.8 1.8 -1.6 0.0 -1.9 -0.9 -1.0 -1.3 0.5 -2.0 -1.9 -1.6 -2.2 -1.7 -1.7 0.5 -1.9 -0.3 -1.2 -0.7
Medication: Cholesterol lowering 2.8 4.4 11.8 -1.8 -2.8 -2.0 -1.3 -0.1 -1.5 -2.4 -2.4 -0.4 0.0 -2.0 2.2 -1.9 -2.5 -1.8 -1.4 -0.8 -1.7 0.4 -2.5 -2.1 -2.3 -3.4 -3.2 -2.7 -0.4 -3.3 -1.7 -3.1 -2.0
Depression (self-reported) 1.6 1.9 4.7 1.2 2.1 1.3 0.7 1.0 1.3 1.3 0.6 1.5 0.0 1.3 -1.9 2.0 0.4 1.2 1.0 1.5 1.3 -0.7 1.6 2.0 1.8 1.3 1.9 2.2 -0.2 1.5 0.5 1.6 0.8
Medication: Lansoprazole 0.4 0.5 1.2 -0.4 -0.6 -0.4 -0.7 0.1 -0.5 0.6 0.1 -1.1 0.0 -0.4 0.9 -1.1 -1.0 -0.8 -0.5 -0.9 -1.1 0.0 -0.4 -1.0 -0.8 -0.0 -0.5 -0.5 0.9 0.2 1.1 -0.4 -0.1
Prospective memory result 0.5 0.7 3.4 0.9 0.0 -0.3 -1.1 -0.6 0.1 -0.2 -0.2 -1.7 0.0 -0.3 0.1 -0.2 0.6 -0.7 -0.3 -1.4 -1.1 1.4 -0.5 -0.2 0.0 -0.0 -0.6 0.6 1.0 0.2 1.8 0.7 1.3
Lung cancer (father) 1.7 2.0 4.5 -0.2 -1.6 -1.6 -1.7 -1.0 -2.1 -0.3 -1.0 2.1 0.0 -1.6 1.4 -1.8 -0.8 -2.0 -1.8 -1.7 -1.5 -0.8 -2.1 -1.9 -1.4 -1.5 -1.4 -1.4 1.2 -1.2 0.0 -0.4 -0.6
Illnesses of mother 1.9 2.4 6.5 1.9 2.2 1.3 0.6 0.7 1.8 2.1 1.2 0.7 0.0 1.3 -1.9 1.3 1.2 1.1 0.3 0.1 0.9 0.2 1.7 1.6 1.9 2.3 1.9 2.1 0.5 2.5 1.3 2.5 1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.8 11.3 -0.3 -0.8 -0.2 -0.5 0.8 -0.5 -0.8 0.3 0.4 0.0 -0.2 1.0 -0.2 0.9 -0.4 -0.0 0.3 -1.2 -3.4 -0.5 -0.4 -1.2 -0.7 -1.1 -1.2 0.7 -0.1 0.7 -0.6 0.5
Pulse wave Arterial Stiffness index 0.4 0.5 2.1 1.2 0.5 -0.3 -1.4 -0.5 -0.1 0.3 -0.7 0.7 0.0 -0.3 -0.4 0.1 0.7 -0.7 -1.0 -1.3 -1.0 -0.1 -0.7 0.2 0.6 -0.2 -0.9 0.6 1.1 0.6 0.0 0.4 1.4
Impedance of arm (left) 0.2 0.8 4.8 0.1 0.4 -0.0 0.9 0.7 -0.3 -0.7 1.0 -0.7 0.0 -0.0 -1.1 1.1 -0.5 0.9 1.0 1.0 1.3 0.4 0.4 1.0 1.3 0.2 0.5 0.6 -2.2 -0.2 -1.6 -0.8 -0.9
Arm fat mass (right) 0.9 3.6 7.6 -1.0 -2.8 -1.9 -1.4 -0.9 -2.2 -1.4 -1.8 -0.7 0.0 -1.9 2.5 -2.2 -1.7 -2.0 -1.3 -1.3 -2.4 -1.9 -2.2 -2.5 -2.7 -2.2 -2.5 -2.7 0.5 -1.8 -0.1 -2.6 -1.4
Trunk predicted mass 0.1 0.8 4.8 1.9 0.9 0.0 -0.9 0.0 -1.1 0.7 -0.3 -0.3 0.0 0.0 -0.9 0.8 1.2 -0.2 -0.4 -0.6 -0.7 -2.2 -0.8 0.8 0.6 -0.8 -1.0 0.2 0.7 0.4 -0.4 0.2 1.6
Standing height 0.4 4.1 16.1 4.0 3.3 0.9 0.1 1.1 -1.3 1.2 1.3 -0.7 0.0 0.9 -3.9 3.5 2.2 1.6 1.0 0.3 1.3 -2.7 0.2 3.4 3.6 0.2 0.3 2.3 -1.3 1.5 -2.0 0.8 2.4
Length of working week for main job 0.7 0.8 2.9 -1.5 -0.8 0.4 1.1 1.2 0.6 -1.7 1.1 0.9 0.0 0.4 0.8 0.2 -0.2 0.7 1.1 1.7 0.1 1.4 0.9 -0.0 -0.8 -0.1 0.0 -0.7 -0.9 -0.5 0.7 -0.9 -0.3
Exposure to tobacco smoke at home 0.6 0.7 3.7 1.6 1.0 0.3 0.1 0.7 0.4 -0.4 0.5 1.9 0.0 0.3 -1.1 0.5 0.0 0.5 0.5 -0.8 0.2 -0.3 0.6 0.8 1.2 1.0 1.0 1.2 -0.6 1.1 0.6 0.6 0.1
Breastfed as a baby 0.5 0.6 4.2 -0.7 0.5 0.4 -0.4 0.2 -0.3 1.8 0.4 0.4 0.0 0.4 -0.1 -0.4 2.0 -0.2 -1.0 -0.9 -0.5 -1.0 0.3 -0.1 0.1 0.4 0.6 -0.0 1.2 0.8 0.7 1.1 1.2
Tense / ‘highly strung’ 0.2 0.3 1.3 -0.1 0.0 0.2 0.7 0.9 0.2 -0.5 0.3 -0.4 0.0 0.2 -0.2 0.3 -1.1 0.6 0.7 0.8 0.7 0.7 0.7 0.2 0.4 0.7 0.7 0.2 -1.1 0.2 -0.3 -0.6 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.6 2.5 5.5 -0.1 2.0 1.6 1.5 0.4 2.3 1.0 1.5 1.1 0.0 1.6 -1.9 2.2 1.7 1.9 1.6 1.9 1.9 1.0 1.8 2.0 1.8 1.5 1.8 2.2 -0.7 1.2 0.4 1.8 1.1
Hair/balding pattern: Pattern 4 1.1 2.7 8.2 -0.2 -1.5 -2.1 -1.5 -0.8 -1.8 -2.6 -2.2 0.8 0.0 -2.1 0.6 -0.4 -1.1 -1.7 -0.6 -0.5 -0.8 -0.3 -2.2 -0.7 -0.6 -2.9 -2.7 -1.4 -0.9 -2.8 -2.2 -2.2 -1.5
Birth weight of first child 0.3 0.6 6.9 0.8 0.5 0.1 -0.2 -0.4 -0.0 0.6 -0.8 0.3 0.0 0.1 -0.7 0.7 0.2 0.2 -0.1 -0.6 0.3 -2.6 -0.9 0.7 0.6 -1.2 -0.9 -0.4 -0.2 -0.8 -1.3 -0.3 0.5
Peak expiratory flow (PEF) 0.2 0.5 2.4 -1.2 -0.6 0.5 0.5 0.3 0.0 -0.2 0.5 0.4 0.0 0.5 0.9 -0.2 -0.2 0.4 0.3 1.4 -0.6 -1.5 -0.2 -0.4 -1.1 -0.3 -0.8 -1.2 -0.1 -0.2 0.3 -1.2 0.2
Pulse wave reflection index 0.9 1.1 3.1 -0.8 -1.3 -1.8 -1.3 0.3 -1.4 -1.6 -0.7 1.3 0.0 -1.8 0.7 -0.6 -0.1 -1.5 -1.2 -0.7 -0.8 0.3 -0.6 -0.9 -0.6 -1.1 -1.1 -0.9 -0.0 -1.4 -1.2 -0.7 -1.1
Ever highly irritable/argumentative for 2 days 0.9 1.1 5.1 -1.3 -0.1 1.4 1.3 1.3 1.6 -0.5 2.0 2.3 0.0 1.4 0.8 0.2 0.0 0.9 1.4 1.9 0.5 1.2 0.8 0.2 -0.8 0.4 0.3 -0.1 0.4 0.2 1.4 0.3 0.6
Loud music exposure frequency 0.2 0.3 1.1 -0.8 0.2 0.1 0.6 -1.0 0.4 -0.1 0.3 -0.1 0.0 0.1 -0.4 0.2 -0.6 0.4 0.7 0.6 0.9 0.2 0.3 0.3 0.4 -0.2 0.3 0.3 -0.8 -0.5 -0.8 -0.3 -0.9
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 6.0 -0.2 -1.0 -1.2 -1.3 -2.3 -1.8 1.0 -1.7 0.5 0.0 -1.2 0.8 -1.7 -0.8 -1.2 -1.6 -2.0 -1.2 -2.3 -2.4 -1.5 -0.9 -1.9 -1.8 -1.8 0.6 -1.4 -1.3 -1.2 -0.1
Mouth/teeth dental problems: Bleeding gums 0.7 1.0 2.8 -0.5 0.5 0.7 1.3 1.6 0.6 -0.8 1.5 1.2 0.0 0.7 -0.6 1.1 -0.5 0.9 1.3 0.9 1.5 -0.1 1.6 1.0 0.6 1.3 1.7 0.8 -1.0 0.5 0.1 0.6 -0.6
Blood clot in the leg (DVT) 0.2 0.2 1.7 -0.8 -0.2 -0.0 -0.1 -0.6 -0.3 -0.3 -0.0 1.2 0.0 -0.0 0.3 -0.1 -1.3 -0.2 -0.1 -0.5 0.1 0.4 -0.4 -0.1 -0.4 -0.2 -0.1 -0.2 0.4 -0.4 0.2 0.4 -0.1
Medication: Paracetamol 0.6 1.0 3.9 -1.5 0.2 0.9 1.8 0.1 0.9 -0.9 0.7 0.4 0.0 0.9 -0.3 0.6 -1.2 1.4 1.4 2.0 1.7 0.8 1.3 0.6 0.2 0.5 1.2 -0.0 -1.5 -0.5 -0.4 0.1 -0.7
Headache pain in last month 1.0 1.7 4.8 -0.7 1.3 1.4 1.9 -1.0 2.1 1.1 0.4 0.0 0.0 1.4 -1.2 1.1 -1.0 1.9 1.4 1.5 2.2 2.0 1.4 1.1 1.3 1.4 1.8 1.2 -1.2 0.8 -0.6 0.6 -0.1
Medication for cholesterol, blood pressure or diabetes 1.4 2.4 6.2 0.9 2.2 1.1 1.3 0.3 1.0 0.5 1.6 0.2 0.0 1.1 -2.3 2.1 0.6 1.6 1.6 1.4 2.1 -0.2 2.2 2.2 2.5 2.0 2.2 2.2 -1.3 1.5 -0.4 1.3 0.1
Glaucoma (self-reported) 1.9 2.2 6.6 1.4 2.0 2.1 0.9 0.5 2.0 1.9 1.8 0.7 0.0 2.1 -1.1 1.4 1.8 1.3 0.5 1.2 1.2 0.0 1.2 1.6 1.0 1.3 1.7 1.6 1.2 1.7 0.9 2.6 1.8
Gout (self-reported) 1.0 1.4 4.5 -0.1 -1.3 -1.1 -1.4 -0.9 -1.4 0.2 -1.5 0.0 0.0 -1.1 1.2 -1.4 1.2 -1.3 -1.2 -1.1 -1.7 -2.1 -1.5 -1.5 -1.4 -1.2 -1.7 -1.6 1.1 -0.7 -0.0 -0.7 0.4
Hypothyroidism/myxoedema (self-reported) 5.6 11.0 20.4 0.6 4.1 3.9 3.7 2.5 4.1 0.5 3.7 -0.9 0.0 3.9 -3.6 4.2 1.0 4.2 4.0 3.8 3.7 2.3 4.5 4.3 3.6 4.1 3.9 4.2 -1.8 3.5 1.7 2.9 2.2
Medication: Amlodipine 1.3 1.8 4.5 0.8 -1.4 -1.1 -1.8 -1.3 -0.9 0.3 -1.4 -1.1 0.0 -1.1 1.7 -1.9 0.3 -1.8 -1.9 -1.5 -2.1 0.7 -1.8 -1.9 -1.6 -1.0 -1.3 -1.3 1.9 -0.5 1.1 -0.1 0.1
Medication: Ventolin 100micrograms inhaler 0.5 0.7 2.7 -1.6 -1.2 -0.2 0.0 -0.3 -0.4 0.1 -0.1 0.2 0.0 -0.2 1.4 -1.3 -0.3 -0.3 -0.3 0.1 -0.6 -1.3 -0.5 -1.2 -1.4 -0.7 -0.8 -1.6 0.4 -1.2 0.2 -0.7 -0.2
Birth weight 0.3 0.6 2.9 -0.0 0.5 -0.6 -0.1 -0.3 0.2 -0.8 -0.9 0.2 0.0 -0.6 -1.2 0.8 -0.9 0.0 0.3 0.1 0.9 -0.3 0.1 0.8 1.2 0.0 0.8 0.7 -1.5 -0.6 -1.7 -0.3 -1.2
Chronic bronchitis/emphysema (mother) 0.4 0.5 2.2 -0.4 -0.9 -0.5 -0.1 1.1 -1.2 -1.3 0.4 -0.7 0.0 -0.5 0.8 -0.3 -0.1 -0.4 0.3 0.8 -0.3 -0.9 -0.5 -0.5 -0.9 -1.2 -0.5 -0.8 -0.3 -1.5 0.1 -0.6 -0.2
High blood pressure (siblings) 2.6 3.7 12.0 -0.4 -2.6 -1.4 -0.3 0.3 -1.8 -3.5 -0.8 -1.1 0.0 -1.4 2.2 -1.5 -2.4 -1.1 0.2 0.2 -0.8 0.4 -2.3 -1.6 -2.2 -3.0 -2.5 -2.6 -1.1 -3.1 -1.8 -3.5 -2.5
Forced vital capacity (FVC), Best measure 0.1 0.5 5.6 0.4 -0.1 0.4 -0.1 0.9 -0.4 -0.4 0.6 -0.1 0.0 0.4 0.5 0.3 1.0 0.0 0.4 0.8 -0.7 -2.4 -0.4 0.2 -0.6 -0.6 -1.0 -0.7 0.7 0.1 0.6 -0.3 1.1
Body fat percentage 0.6 2.4 7.2 -1.0 -2.3 -1.4 -0.6 -0.5 -1.8 -1.7 -0.9 -0.7 0.0 -1.4 1.9 -1.7 -2.2 -1.2 -0.6 -0.7 -1.4 -1.4 -1.3 -2.0 -2.1 -1.6 -1.7 -2.1 -0.5 -1.7 -0.5 -2.7 -2.0
Leg fat percentage (right) 0.4 1.6 5.5 -1.3 -2.1 -1.1 -0.1 -0.4 -0.9 -1.7 -0.6 -0.4 0.0 -1.1 1.7 -1.5 -2.3 -0.9 -0.5 -0.3 -1.0 -0.4 -0.4 -1.8 -1.9 -0.6 -0.7 -1.7 -0.6 -1.2 -0.2 -2.1 -2.2
Arm fat-free mass (right) 0.2 1.0 6.8 1.9 0.2 -0.2 -1.2 -0.1 -1.6 0.5 -0.7 -0.5 0.0 -0.2 -0.1 0.2 0.7 -0.6 -0.8 -1.2 -1.5 -2.6 -1.3 0.1 -0.3 -1.4 -1.8 -0.6 1.1 0.0 -0.0 -0.5 1.5
Exposure to tobacco smoke outside home 0.4 0.5 5.1 -0.2 -0.1 0.1 -0.0 0.4 0.8 0.4 0.2 0.4 0.0 0.1 0.4 -0.6 0.7 -0.0 0.0 0.6 -0.6 2.3 0.4 -0.6 -0.4 1.2 0.7 0.3 0.6 1.2 1.6 0.5 0.6
Comparative body size at age 10 1.4 3.9 13.9 -2.9 -3.4 -1.5 -0.8 -0.8 -1.6 -1.7 -1.4 0.4 0.0 -1.5 3.6 -2.8 -0.9 -2.0 -1.0 -1.0 -2.0 -0.3 -1.3 -3.0 -3.7 -1.7 -1.3 -2.9 1.3 -2.0 1.2 -1.6 -1.7
Number of full brothers 1.9 2.4 7.6 1.2 1.9 1.3 1.3 1.0 2.1 -1.1 2.4 0.1 0.0 1.3 -2.0 2.8 0.9 1.6 1.9 1.6 1.8 -1.0 2.1 2.6 2.0 0.8 1.4 1.8 -1.3 0.8 -0.5 0.6 -0.2
Worry too long after embarrassment 0.3 0.5 1.9 -0.5 -0.4 -0.3 -0.2 -0.7 -0.2 0.2 -0.8 -0.6 0.0 -0.3 0.2 -0.1 -1.4 -0.1 -0.2 -0.2 -0.2 -0.7 -1.1 -0.2 -0.3 -1.3 -1.2 -1.0 -0.5 -0.8 -1.3 -1.4 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.9 2.5 7.2 1.3 2.4 1.1 0.9 1.2 1.9 1.1 0.3 1.0 0.0 1.1 -2.7 2.3 0.5 1.6 1.2 1.1 1.8 0.1 1.6 2.2 2.7 2.0 1.7 2.6 -1.1 1.8 -0.3 1.2 0.7
Wheeze or whistling in the chest in last year 1.2 2.2 8.4 -0.8 1.0 2.5 2.9 1.2 1.7 0.5 2.1 0.5 0.0 2.5 -0.3 0.5 -0.2 2.4 1.6 2.1 2.3 1.3 1.5 0.8 0.3 1.8 2.0 0.3 -0.6 0.7 0.6 0.9 0.3
Number of children fathered 0.7 0.8 3.0 -0.9 -1.0 -0.9 -0.5 -0.1 -0.7 -0.8 -0.7 -1.4 0.0 -0.9 0.8 -0.8 -0.9 -0.8 -0.3 -0.2 -0.4 0.2 -0.5 -0.9 -0.9 -1.1 -0.7 -0.9 -0.4 -1.3 -1.0 -1.5 -1.7
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.7 -0.7 -0.4 -0.1 -0.1 -0.2 -0.6 -0.1 0.7 0.8 0.0 -0.1 0.4 -0.8 -0.2 -0.2 -0.4 0.2 0.0 -0.2 -0.5 -0.6 -0.3 -0.8 -0.4 -0.5 0.1 -0.8 -0.7 -0.4 -0.4
Age at first live birth 1.5 2.7 9.4 0.9 -0.8 -2.6 -2.8 -2.6 -2.3 0.8 -2.7 -0.4 0.0 -2.6 0.0 -1.4 0.4 -2.6 -3.1 -2.9 -1.5 -0.5 -1.8 -1.3 -0.1 -0.7 -0.2 -0.4 0.9 -0.6 -1.5 0.2 -0.6
Pulse wave peak to peak time 0.4 0.4 2.0 -0.7 -0.2 0.5 1.4 0.6 0.0 -0.0 0.8 -0.9 0.0 0.5 0.1 0.1 -0.2 0.9 1.0 1.4 1.0 -0.2 0.7 0.1 -0.4 0.2 0.8 -0.4 -1.0 -0.3 -0.0 -0.3 -0.9
Health satisfaction 0.6 0.8 5.1 -0.7 0.7 1.2 1.1 0.0 2.3 -0.0 0.9 0.5 0.0 1.2 -0.4 0.4 0.3 1.2 1.3 1.3 0.9 1.1 0.9 0.6 0.5 0.7 0.6 0.7 -0.1 0.6 0.8 0.7 0.5
Shortness of breath walking on level ground 0.5 0.6 2.8 0.6 0.5 -0.1 -0.7 -0.8 0.3 0.1 -0.3 -0.2 0.0 -0.1 -0.3 -0.0 1.2 -0.4 -0.4 -0.3 -0.5 1.4 0.2 -0.0 0.3 0.9 0.9 1.1 1.1 0.9 1.7 1.5 1.1
Qualifications: College or University degree 1.6 5.1 12.8 0.8 -1.8 -3.6 -3.0 -2.0 -2.9 -0.8 -2.8 1.1 0.0 -3.6 0.5 -1.6 -2.3 -3.0 -3.1 -2.1 -1.6 0.2 -3.3 -1.7 -0.6 -3.0 -2.1 -1.6 -0.3 -3.0 -3.5 -1.8 -2.2
Eye problems/disorders: None of the above 5.4 6.2 11.2 -0.6 -3.1 -3.2 -2.8 -1.8 -2.8 -0.9 -3.4 -1.3 0.0 -3.2 2.4 -2.9 -1.8 -3.2 -2.8 -3.0 -2.7 -1.5 -2.7 -3.1 -2.2 -2.2 -2.7 -2.9 0.4 -2.3 -1.8 -3.3 -2.6
Mouth/teeth dental problems: Loose teeth 0.8 0.9 3.9 -1.6 -0.7 0.3 1.4 0.9 1.0 -1.1 1.3 -0.6 0.0 0.3 0.7 -0.3 -1.8 0.5 1.0 1.2 1.1 0.7 1.0 -0.3 -0.6 0.5 1.0 -0.2 -1.1 -0.7 -0.2 -0.7 -2.0
Emphysema/chronic bronchitis 6.3 7.1 17.0 -0.6 2.4 2.9 3.4 3.5 3.5 -0.9 3.5 1.5 0.0 2.9 -2.0 2.9 0.8 3.3 3.6 4.1 3.1 3.0 3.5 3.0 2.1 2.7 3.0 3.0 -1.6 1.9 2.0 2.3 1.2
Medication for pain relief, constipation, heartburn 0.8 1.5 5.0 2.2 1.8 0.7 0.2 1.0 0.0 2.0 1.2 0.0 0.0 0.7 -1.9 1.1 1.2 0.9 -0.2 -0.2 0.7 -1.5 1.1 1.4 1.8 1.6 1.3 1.5 -0.2 1.8 -0.5 1.0 0.8
Neck or shoulder pain in last month 7.4 10.6 27.6 -0.1 3.1 5.3 4.2 2.6 4.7 1.8 4.6 0.4 0.0 5.3 -1.4 2.8 2.4 4.5 3.8 4.4 2.7 2.8 4.0 2.9 1.5 3.5 2.8 2.5 0.1 3.5 3.2 2.4 3.8
Medication: Blood pressure 1.2 2.1 8.7 -0.9 -1.9 -0.3 -0.9 -0.1 -0.0 0.1 -0.8 0.4 0.0 -0.3 2.7 -2.2 0.0 -1.3 -1.1 -0.8 -2.4 0.0 -1.5 -2.2 -2.9 -0.7 -1.2 -1.8 2.3 -0.3 2.7 -0.2 0.8
Angina (self-reported) 0.6 0.7 2.6 -1.2 -1.1 -0.5 -0.7 0.3 0.0 0.0 -1.2 1.0 0.0 -0.5 1.4 -0.8 0.6 -1.2 -0.8 -0.0 -1.0 -0.8 -0.0 -1.1 -1.4 -0.1 0.0 -0.6 1.6 -0.0 1.6 0.6 -0.3
Migraine (self-reported) 0.3 0.4 1.3 -0.5 -0.5 0.1 -0.2 0.7 0.7 0.9 0.0 -1.1 0.0 0.1 0.8 -1.0 1.0 -0.1 -0.5 -0.0 -0.8 0.3 -0.2 -0.9 -1.0 -0.4 -0.3 -0.8 0.8 -0.0 0.3 -0.2 0.7
Medication: Ibuprofen 0.8 0.9 3.6 -0.9 -1.3 -1.3 -0.6 -0.9 -0.8 -1.3 -1.2 -0.1 0.0 -1.3 0.8 -0.5 -0.4 -0.9 -0.2 -0.2 -0.5 0.9 -1.2 -0.8 -0.6 -1.9 -1.4 -0.9 -0.4 -1.6 -0.9 -1.2 -0.7
Medication: Allopurinol 0.5 0.6 2.1 -0.2 -1.1 -0.5 -0.6 0.3 -1.2 -0.2 -0.5 0.4 0.0 -0.5 1.0 -0.8 0.6 -0.5 -0.3 0.1 -1.4 -1.4 -0.9 -1.0 -1.2 -0.5 -1.4 -1.2 0.4 -0.1 0.5 -1.1 0.6
Medication: Omeprazole 1.7 2.0 6.2 -0.1 1.4 2.1 1.8 1.3 2.5 0.1 1.1 1.4 0.0 2.1 -0.7 1.2 0.6 2.0 1.8 1.4 1.1 1.3 1.8 1.3 0.7 1.8 1.2 1.4 -0.1 1.5 1.7 0.9 1.3
Medication: Seretide 50 evohaler 0.8 0.9 3.1 -0.2 0.9 0.7 0.4 -0.5 1.5 1.1 0.2 0.1 0.0 0.7 -0.5 0.1 0.9 0.4 0.4 0.6 0.4 1.2 1.2 0.4 0.5 1.7 1.7 1.2 0.6 1.3 1.6 1.7 0.6
Mean time to correctly identify matches 3.2 6.1 25.3 1.2 -1.5 -1.4 -3.6 -2.0 -1.1 2.4 -2.7 1.0 0.0 -1.4 2.5 -3.0 1.2 -3.2 -3.8 -3.5 -4.2 -1.3 -2.6 -2.9 -2.5 -0.0 -1.7 -1.5 5.0 1.3 3.0 1.1 2.0
Heart disease (mother) 0.2 0.2 1.9 -1.2 -0.3 -0.2 -0.3 -0.2 0.3 -0.3 -0.5 1.4 0.0 -0.2 0.3 -0.4 -0.2 -0.3 -0.1 0.8 -0.6 0.9 -0.1 -0.4 -0.3 0.4 -0.1 -0.0 0.4 0.2 0.4 -0.0 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 5.4 -1.5 0.4 1.3 1.9 2.2 0.7 -0.9 2.3 1.6 0.0 1.3 -0.2 0.8 -0.4 1.5 1.8 1.8 1.3 0.9 1.4 0.8 0.1 1.0 0.7 0.4 -1.1 0.3 0.4 -0.2 -0.4
Whole body fat mass 0.5 2.2 6.0 -0.6 -2.1 -1.4 -0.9 -0.5 -2.0 -1.5 -0.9 -0.5 0.0 -1.4 1.7 -1.5 -1.8 -1.3 -0.7 -0.8 -1.8 -1.8 -1.6 -1.8 -2.0 -1.7 -2.0 -2.0 -0.1 -1.5 -0.3 -2.5 -1.3
Leg fat mass (right) 0.5 1.8 4.7 -0.8 -2.0 -1.3 -0.7 -0.3 -1.5 -1.6 -0.9 -0.3 0.0 -1.3 1.7 -1.5 -2.0 -1.2 -0.7 -0.7 -1.6 -1.5 -1.0 -1.7 -2.0 -1.1 -1.4 -1.9 -0.1 -1.1 -0.0 -2.2 -1.5
Arm predicted mass (right) 0.2 1.1 7.2 1.7 -0.0 -0.5 -1.4 -0.1 -1.6 0.4 -0.8 -0.5 0.0 -0.5 0.1 -0.1 0.7 -0.8 -0.9 -1.2 -1.7 -2.7 -1.3 -0.1 -0.5 -1.4 -1.7 -0.7 1.1 -0.0 0.0 -0.5 1.3
Pulse rate, automated reading 2.4 7.7 18.1 1.5 3.6 3.8 2.7 1.4 3.4 1.7 3.0 -1.0 0.0 3.8 -2.4 2.5 0.8 3.3 3.1 2.0 2.1 0.9 3.4 3.1 2.4 4.2 3.2 3.4 -0.0 4.2 3.1 2.9 2.9
Alcohol intake frequency. 1.9 4.4 11.1 0.1 1.5 2.7 2.9 3.2 2.6 -1.3 2.6 -0.1 0.0 2.7 -1.1 2.4 -0.7 3.0 3.3 2.9 2.0 1.4 3.0 2.2 1.4 2.5 1.9 2.0 -1.6 1.8 1.7 0.2 0.8
Comparative height size at age 10 0.5 2.5 8.9 2.4 2.8 0.9 -0.3 0.4 -0.0 1.6 1.0 -0.4 0.0 0.9 -3.0 2.3 2.4 1.1 0.3 -0.6 0.5 -1.9 0.2 2.4 2.8 0.6 -0.0 2.1 -0.2 2.1 -0.5 1.1 2.8
Number of full sisters 0.6 0.7 3.4 -0.5 -0.8 0.3 0.5 1.8 -0.1 -1.6 0.9 0.2 0.0 0.3 0.8 -0.1 -0.2 0.4 1.4 0.7 -0.4 1.1 -0.5 -0.1 -0.6 -1.2 -1.8 -0.5 -0.6 -0.7 0.5 -1.6 0.4
Suffer from ‘nerves’ 2.0 3.1 10.6 -0.1 1.5 1.8 2.6 1.8 1.8 -1.2 0.9 -1.0 0.0 1.8 -1.9 2.6 -1.4 2.9 3.3 2.5 2.2 0.3 1.5 2.4 1.8 0.1 -0.1 1.0 -3.0 0.0 -1.4 -1.6 -0.3
Overall health rating 2.4 5.1 14.2 -1.5 1.2 3.2 3.2 2.3 3.4 -0.4 2.6 2.6 0.0 3.2 -0.2 1.2 0.9 3.0 3.0 3.8 1.7 3.6 3.1 1.3 0.1 2.3 1.9 1.5 -0.4 1.9 2.8 1.1 1.3
Chest pain or discomfort 1.5 2.1 6.8 -2.0 0.9 1.8 2.3 1.6 2.1 -1.1 1.0 0.1 0.0 1.8 -0.8 1.6 0.2 2.1 2.6 1.9 2.0 2.1 1.6 1.5 0.8 0.8 1.1 1.1 -1.5 0.2 0.2 0.2 0.3
Had major operations 0.6 0.7 2.3 0.4 0.8 1.2 1.1 0.7 0.8 0.1 0.6 0.9 0.0 1.2 -0.6 1.1 -0.4 1.2 1.3 1.1 1.3 1.5 0.0 1.0 0.6 -0.2 -0.0 0.8 -0.5 -0.0 -0.1 0.3 0.8
Age at last live birth 1.6 2.3 8.0 0.8 -1.0 -2.8 -1.8 -1.9 -2.0 -1.0 -2.3 -0.6 0.0 -2.8 -0.4 -0.7 -0.9 -1.9 -1.7 -2.0 -0.4 -0.1 -1.5 -0.8 0.4 -1.2 -0.2 -0.7 -1.3 -1.7 -2.8 -1.1 -2.1
Family relationship satisfaction 0.1 0.1 1.1 -0.6 0.1 -0.1 -0.3 -0.1 0.7 0.0 -0.1 1.0 0.0 -0.1 -0.2 0.3 0.7 -0.1 -0.3 0.0 -0.2 0.4 0.2 0.1 0.4 0.1 -0.1 0.3 0.5 0.6 0.4 0.4 0.3
Leg pain on walking 0.4 0.5 2.2 1.5 -0.3 -0.6 -1.1 -1.1 -0.4 0.1 0.3 -0.8 0.0 -0.6 0.4 -0.6 1.3 -1.1 -0.8 -0.1 -0.8 0.1 -0.6 -0.7 -0.3 -0.3 -0.0 -0.0 1.1 -0.1 1.0 1.0 0.9
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.6 6.0 -0.7 0.5 2.0 1.5 1.6 1.4 0.5 1.5 -0.9 0.0 2.0 0.4 0.4 1.8 1.7 1.7 1.8 -0.1 0.3 1.0 0.5 -0.5 1.1 0.1 0.2 0.6 1.5 2.5 0.4 2.3
Commuting to job workplace: Car/motor vehicle 0.3 0.4 1.9 0.3 0.3 -0.3 0.1 -1.2 0.3 0.3 -0.4 1.4 0.0 -0.3 -0.6 -0.1 -1.2 0.1 -0.2 -0.5 0.5 -0.9 0.3 0.1 0.5 0.4 0.7 0.4 -0.8 -0.0 -1.0 -0.4 -0.9
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 2.9 1.6 0.7 0.4 -0.7 0.3 -0.7 0.8 -0.2 0.5 0.0 0.4 -0.4 0.4 0.5 -0.0 -0.4 -0.8 -0.5 -1.6 -1.3 0.4 0.3 -1.3 -1.7 -0.3 0.6 -0.2 -0.8 -0.6 1.2
Medication: Aspirin 1.0 1.4 3.8 -0.9 -1.2 -0.7 -1.4 -0.7 -0.6 0.2 -0.9 0.3 0.0 -0.7 1.7 -1.4 0.2 -1.4 -1.4 -1.4 -1.9 0.7 -1.6 -1.6 -1.7 -1.2 -1.7 -1.2 1.9 -0.4 1.0 -0.3 0.2
Supplements: Vitamin C 0.5 0.6 3.0 0.4 0.2 -0.9 -0.6 -1.5 -0.8 0.2 -0.8 -0.9 0.0 -0.9 -0.7 -0.0 0.0 -0.7 -0.9 -1.1 0.7 -0.8 -0.3 0.2 0.8 -0.3 0.5 0.3 -0.4 -0.6 -1.7 0.4 -1.4
Knee pain experienced in last month 0.3 0.4 2.3 0.3 -0.8 -0.7 -0.4 0.8 -0.4 -1.5 -0.8 0.2 0.0 -0.7 0.6 -0.2 -0.4 -0.5 0.2 0.8 -0.5 0.4 -0.7 -0.4 -0.7 -1.3 -0.8 -0.5 -0.2 -0.9 -0.0 -0.9 -0.5
Hypertension (Self-reported) 0.6 1.5 6.7 -1.4 -2.0 -0.2 -0.1 0.8 -0.9 -1.4 -0.3 0.6 0.0 -0.2 2.5 -1.7 -1.2 -0.8 -0.3 0.4 -1.3 1.2 -1.1 -1.8 -2.6 -0.9 -0.7 -1.6 1.0 -1.4 1.7 -0.7 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 3.9 -0.2 0.4 1.3 1.5 1.0 0.7 -0.5 2.0 -0.3 0.0 1.3 -0.1 0.5 -0.0 1.3 1.9 1.3 0.9 1.0 1.3 0.6 0.1 0.4 0.3 0.6 -0.7 0.0 0.7 -0.2 0.0
Illnesses of father: Heart disease 0.4 0.5 3.1 1.4 0.8 -0.5 -0.4 -0.6 -0.0 -0.2 0.0 -1.8 0.0 -0.5 -1.3 1.0 0.7 0.0 -0.3 -0.6 0.2 -0.2 0.5 0.8 1.3 0.6 0.6 0.9 -0.5 0.5 -0.1 0.9 0.3
Illnesses of siblings: Diabetes 0.5 0.6 2.6 0.6 0.9 -0.3 0.2 -0.0 0.8 -0.8 0.5 0.5 0.0 -0.3 -1.5 1.3 -0.3 0.4 0.3 0.2 0.9 0.4 0.6 1.1 1.4 -0.0 0.2 1.1 -1.4 0.2 -1.6 -0.2 -0.9
Smoking status: Previous 0.1 0.2 1.4 -0.8 -0.1 -0.3 -0.0 0.3 -0.2 0.1 -0.3 -0.7 0.0 -0.3 -0.3 -0.0 0.7 -0.1 -0.3 -0.2 0.3 0.7 -0.3 -0.1 0.2 -0.6 -0.3 -0.4 -0.4 -0.5 -1.2 -0.0 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 5.7 1.1 1.5 1.2 1.6 1.1 1.0 -0.3 1.4 -0.9 0.0 1.2 -2.0 2.4 -0.1 2.1 2.2 1.8 1.6 0.3 1.1 2.2 1.8 0.0 0.3 1.2 -2.3 0.4 -1.3 -0.9 0.4
Whole body fat-free mass 0.1 0.8 6.3 1.2 0.1 -0.2 -1.0 -0.1 -1.6 0.4 -0.6 -0.4 0.0 -0.2 -0.0 0.1 0.7 -0.5 -0.5 -0.7 -1.3 -2.5 -1.2 0.0 -0.3 -1.3 -1.6 -0.7 0.8 -0.1 -0.1 -0.6 1.3
Leg fat-free mass (right) 0.3 1.7 8.4 0.3 -0.9 -0.7 -1.3 -0.6 -2.3 0.2 -1.2 -0.7 0.0 -0.7 1.0 -0.9 -0.1 -1.1 -0.9 -1.1 -1.9 -2.9 -2.0 -1.0 -1.3 -1.9 -2.4 -1.7 1.1 -0.8 -0.0 -1.5 0.8
Arm fat percentage (left) 1.1 4.5 10.9 -1.9 -3.3 -1.9 -1.0 -1.0 -2.2 -2.0 -1.6 -0.6 0.0 -1.9 2.9 -2.6 -2.8 -1.9 -1.0 -1.0 -2.1 -1.3 -2.0 -2.9 -3.1 -2.3 -2.5 -3.0 -0.1 -2.4 -0.4 -3.3 -2.4
Average weekly red wine intake 1.9 2.8 12.3 0.8 -0.3 -2.1 -2.9 -3.5 -2.4 1.1 -2.4 -0.3 0.0 -2.1 -0.1 -0.8 0.6 -2.3 -2.6 -2.8 -1.8 -1.1 -2.1 -1.0 0.0 -1.5 -1.4 -0.4 1.6 -0.4 -0.9 0.4 0.4
Handedness (chirality/laterality): Left-handed 1.2 1.5 7.0 -1.0 -0.8 0.3 -0.4 -0.1 -0.1 1.5 -0.7 1.8 0.0 0.3 1.7 -1.8 2.6 -0.6 -0.9 -0.5 -1.4 -1.2 -0.7 -1.5 -1.8 0.4 -0.1 -1.1 2.1 0.9 1.8 0.5 1.3
Mood swings 1.0 1.8 6.9 -2.3 -1.1 -0.1 1.8 0.9 0.2 -2.1 1.2 0.3 0.0 -0.1 0.5 0.3 -2.0 1.1 1.9 1.9 1.4 1.1 0.6 -0.1 -0.3 -0.5 0.2 -0.8 -2.6 -1.8 -1.2 -1.8 -2.2
Loneliness, isolation 1.2 1.6 5.4 -0.3 0.8 1.9 2.1 1.7 1.9 -0.3 1.6 0.3 0.0 1.9 -0.6 1.5 -0.4 2.1 2.2 2.3 1.5 0.9 1.3 1.3 0.7 -0.1 0.1 0.6 -1.5 0.2 -0.2 -0.8 0.2
Long-standing illness, disability or infirmity 0.6 0.9 5.3 -0.3 0.6 1.4 0.7 1.0 1.0 0.1 0.5 1.8 0.0 1.4 -0.0 0.3 -0.4 1.0 1.0 1.6 0.1 2.3 0.4 0.5 0.1 0.4 -0.2 0.6 0.4 0.8 1.4 0.4 1.6
Ever had bowel cancer screening 1.5 1.8 5.8 -1.3 0.2 1.5 1.9 2.4 0.6 -1.6 1.8 1.3 0.0 1.5 -0.1 0.9 -1.8 1.8 1.9 2.1 1.0 0.8 0.6 0.9 0.1 -0.5 -0.9 -0.6 -1.8 -1.0 -1.0 -2.1 -0.5
Diabetes diagnosed by doctor 0.6 1.0 3.6 1.6 1.6 0.7 0.1 1.0 1.2 -0.0 -0.5 1.4 0.0 0.7 -1.8 1.6 0.2 0.7 0.8 0.6 0.7 0.8 0.7 1.6 1.7 0.3 0.2 1.9 -0.4 0.8 -0.1 0.8 0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.6 0.9 0.4 0.5 0.2 -0.2 0.4 0.6 0.7 -0.8 0.0 0.5 -0.2 0.3 1.2 0.3 0.1 -0.1 -0.1 -1.1 0.8 0.2 0.1 0.7 0.6 0.2 0.4 0.6 0.7 0.6 0.8
Friendships satisfaction 0.4 0.5 4.6 -2.1 -0.1 -0.4 0.2 -0.0 0.9 -0.1 0.2 0.3 0.0 -0.4 -0.3 0.4 0.4 0.3 0.6 1.3 0.4 1.7 0.7 0.2 0.5 -0.2 -0.2 0.3 -0.9 -0.1 -0.4 -0.4 -0.5
Qualifications: nursing, teaching 1.3 2.1 7.0 0.5 -1.0 -1.7 -2.5 -1.3 -1.3 0.8 -1.6 -0.2 0.0 -1.7 1.0 -1.4 0.1 -2.1 -2.5 -2.6 -2.5 -0.2 -1.7 -1.5 -1.3 -0.9 -1.5 -1.1 1.7 -0.3 -0.1 -0.3 0.7
Commuting to job workplace: Walk 0.8 0.8 3.4 0.4 -0.7 -1.2 -1.5 -0.3 -0.7 -0.4 0.1 -1.6 0.0 -1.2 0.5 -0.4 1.8 -1.5 -1.1 -1.1 -1.3 -0.2 -1.0 -0.6 -0.4 -0.9 -1.1 -0.5 1.2 -0.2 0.4 0.6 0.5
Eye problems/disorders: Cataract 0.3 0.3 2.4 -0.7 0.0 0.3 0.6 0.0 0.2 -0.3 1.0 1.1 0.0 0.3 0.0 -0.1 -1.0 0.4 0.6 1.0 0.5 1.6 0.1 -0.0 -0.2 -0.2 0.4 0.3 -0.3 -0.5 0.2 0.3 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 3.0 1.0 0.7 -0.4 -0.6 -1.0 -0.4 0.7 0.2 0.1 0.0 -0.4 -0.9 0.2 0.2 -0.2 -0.6 -0.5 -0.1 1.7 0.1 0.2 0.8 0.8 0.6 1.1 0.2 0.7 -0.0 0.9 0.3
Medication for cholesterol 0.3 0.5 3.3 0.1 0.1 -0.3 -0.6 -1.8 -0.7 0.8 -0.2 0.6 0.0 -0.3 -0.1 -0.4 0.9 -0.5 -0.5 -1.0 -0.4 -1.6 -0.3 -0.2 0.1 0.1 0.2 -0.1 0.8 0.5 0.2 0.9 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 3.2 -1.4 -1.3 -1.5 -1.0 -1.8 -0.4 -0.2 -0.6 1.0 0.0 -1.5 0.8 -1.2 -1.4 -1.1 -1.3 -1.1 -0.8 -0.2 -1.0 -1.3 -0.8 -0.9 -0.8 -1.1 0.0 -1.2 -0.8 -0.6 -0.9
Back pain experienced in last month 0.5 0.7 3.1 -1.8 -0.5 0.8 0.9 -0.2 1.0 -0.9 0.4 1.3 0.0 0.8 1.1 -0.7 0.7 0.4 0.7 1.2 -0.2 0.3 0.8 -0.7 -1.1 0.6 0.7 -0.5 0.5 0.4 1.8 0.3 0.0
Mineral and other dietary supplements 3.0 4.0 7.7 0.9 1.9 2.7 2.3 2.6 2.6 0.7 2.7 0.7 0.0 2.7 -1.2 2.4 1.4 2.6 2.8 2.0 1.2 0.2 2.6 2.1 1.2 2.4 1.6 1.9 -0.4 2.6 2.5 1.2 2.2
Breast cancer (self-reported) 0.5 0.6 2.4 0.3 0.7 0.9 0.5 -0.1 1.5 -0.1 0.0 -0.2 0.0 0.9 -0.3 0.6 -0.4 0.6 0.9 0.9 0.4 1.2 1.0 0.6 0.2 1.4 0.9 1.0 0.4 1.3 1.0 0.7 0.5
Asthma (self-reported) 0.2 0.5 1.9 0.3 -0.5 -0.7 -0.2 -1.0 -0.3 -0.6 -1.3 0.7 0.0 -0.7 0.1 -0.6 -0.7 -0.4 -0.7 -0.1 0.2 -1.0 -0.6 -0.4 -0.0 -0.7 -0.2 -0.9 -0.6 -1.4 -1.3 -0.5 -0.9
Osteoporosis (self-reported) 0.5 0.6 2.1 0.2 -0.9 -1.5 -0.9 -1.4 -0.8 -1.1 -0.1 1.2 0.0 -1.5 0.4 -0.5 -1.0 -1.2 -1.0 -0.9 -0.2 -0.2 -0.3 -0.7 -0.5 -0.2 0.4 -0.2 -0.0 -0.8 -0.2 0.3 -1.4
Osteoarthritis (self-reported) 0.6 0.7 3.7 -0.4 0.1 1.2 0.7 0.9 1.0 -0.6 0.2 1.3 0.0 1.2 0.4 0.5 0.4 0.9 1.1 1.3 -0.4 0.7 -0.4 0.5 -0.6 -1.4 -1.9 -0.5 0.1 -0.3 0.2 -1.3 1.0
Medication: Aspirin 1.2 1.6 4.6 -0.8 -1.3 -0.8 -1.5 -1.2 -0.6 0.4 -1.1 0.5 0.0 -0.8 1.7 -1.6 0.5 -1.6 -1.7 -1.5 -2.1 0.6 -1.6 -1.8 -1.8 -1.1 -1.6 -1.3 2.2 -0.3 1.2 -0.1 0.4
Medication: Gliclazide 1.2 1.3 4.2 1.1 1.8 0.7 -0.4 -0.4 1.5 1.3 0.7 1.7 0.0 0.7 -1.6 1.3 1.7 0.6 -0.0 -0.3 -0.1 1.4 0.6 1.3 1.5 0.4 -0.1 1.8 0.7 1.7 0.2 1.5 2.0
Illnesses of father: None of the above (group 1) 0.5 0.7 2.9 -0.7 -0.1 -0.3 -0.4 -1.0 -0.9 0.7 -0.9 0.7 0.0 -0.3 -0.0 -0.6 -1.7 -0.4 -0.6 -1.2 0.2 -1.6 -1.2 -0.4 0.0 -0.9 -0.7 -0.6 -0.0 -0.8 -1.6 -0.7 -0.7
Smoking status: Current 0.5 0.8 2.8 -0.9 -0.2 0.5 1.4 1.0 0.6 -1.0 0.6 0.9 0.0 0.5 0.3 0.4 -1.2 0.7 1.2 1.4 1.1 1.7 1.2 0.3 -0.2 0.9 1.1 0.4 -1.2 0.0 0.1 -0.7 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.3 6.3 -1.7 -2.1 -1.0 -1.3 -0.7 -0.9 -0.6 -1.6 0.2 0.0 -1.0 2.5 -2.2 -0.8 -1.5 -1.2 -0.9 -2.4 -0.4 -1.8 -2.2 -2.5 -1.5 -2.1 -2.2 1.5 -1.0 1.0 -1.2 -0.0
Whole body water mass 0.1 0.8 5.7 1.3 0.1 -0.2 -1.0 0.0 -1.6 0.3 -0.7 -0.4 0.0 -0.2 -0.0 0.1 0.7 -0.5 -0.5 -0.8 -1.3 -2.4 -1.3 0.0 -0.3 -1.3 -1.7 -0.6 0.9 -0.1 -0.1 -0.7 1.4
Leg predicted mass (right) 0.3 1.7 8.7 0.4 -0.8 -0.7 -1.4 -0.6 -2.3 0.2 -1.3 -0.7 0.0 -0.7 1.0 -0.9 0.0 -1.1 -1.0 -1.2 -1.9 -2.9 -2.0 -0.9 -1.3 -1.9 -2.4 -1.6 1.1 -0.8 -0.1 -1.4 0.8
Arm fat mass (left) 0.8 3.4 7.8 -1.1 -2.6 -1.7 -1.2 -0.6 -2.1 -1.6 -1.6 -0.6 0.0 -1.7 2.4 -2.0 -1.9 -1.7 -1.0 -1.1 -2.2 -2.0 -2.0 -2.3 -2.7 -2.2 -2.6 -2.7 0.3 -1.9 -0.2 -2.8 -1.4
Number of self-reported non-cancer illnesses 1.0 1.7 5.6 -1.4 0.1 1.9 2.1 2.4 1.3 -1.0 1.5 2.2 0.0 1.9 0.4 0.7 -1.6 1.9 2.2 2.2 1.0 0.1 0.7 0.6 -0.5 -0.1 -0.2 -0.3 -0.9 -0.4 0.8 -0.7 0.4
Average weekly champagne plus white wine intake 3.1 4.3 12.4 1.2 -1.4 -2.7 -2.6 -2.8 -3.5 -0.4 -2.7 0.9 0.0 -2.7 0.6 -1.3 -2.5 -2.6 -2.7 -2.9 -1.6 -2.7 -3.0 -1.4 -0.6 -2.3 -1.9 -1.6 0.4 -2.2 -2.1 -1.2 -1.5
Miserableness 0.5 0.8 2.7 -1.7 -1.3 -0.3 0.1 0.5 -0.7 -0.3 0.3 1.1 0.0 -0.3 1.4 -0.9 -1.4 -0.3 0.1 0.4 -0.5 0.4 -0.8 -1.1 -1.6 -1.0 -0.8 -1.3 -0.0 -1.2 -0.1 -1.4 -0.9
Guilty feelings 1.1 1.7 4.9 0.2 -0.9 -1.9 -1.8 -1.6 -1.6 -0.1 -1.1 -0.9 0.0 -1.9 0.2 -0.8 -0.9 -1.6 -1.3 -1.6 -0.9 -1.1 -2.2 -0.9 -0.2 -2.2 -1.6 -1.1 0.1 -1.6 -1.8 -0.9 -0.8
Wears glasses or contact lenses 0.4 0.4 1.7 0.1 -0.2 -0.2 -0.8 -0.6 -0.1 0.1 -0.9 1.2 0.0 -0.2 0.5 -0.4 -0.5 -0.8 -0.9 -1.3 -0.5 -0.3 -0.9 -0.4 -0.5 -0.6 -0.6 -0.5 1.3 -0.6 0.1 0.4 0.5
Ever taken oral contraceptive pill 0.8 0.9 2.7 -0.8 0.0 0.7 1.6 1.6 0.6 -1.6 1.0 1.4 0.0 0.7 -0.1 0.5 -1.0 1.2 1.6 1.4 1.1 0.4 1.3 0.5 0.1 0.6 1.0 0.3 -1.4 -0.0 0.2 -0.4 -1.0
Hearing aid user 0.6 0.7 2.9 0.3 0.9 0.8 0.0 -0.8 1.2 0.8 0.3 -1.0 0.0 0.8 -0.4 0.6 0.3 0.3 -0.1 -0.0 -0.2 0.3 1.0 0.5 0.6 1.2 0.7 1.2 1.0 1.4 1.7 1.3 1.5
Mother’s age at death 0.3 0.4 1.7 0.6 0.9 0.4 0.0 -0.1 0.4 -0.1 -0.5 1.3 0.0 0.4 -0.8 1.0 0.8 0.3 0.6 -0.3 0.7 -1.1 -0.1 1.0 0.8 -1.0 -0.3 0.7 0.0 -0.8 -0.4 0.7 0.5
Financial situation satisfaction 0.4 0.5 2.3 0.3 1.2 0.3 0.1 -0.6 1.2 0.4 -0.0 -0.6 0.0 0.3 -1.5 1.0 0.6 0.6 0.4 0.4 0.7 0.1 0.4 1.1 1.5 -0.0 0.1 1.1 -0.4 0.6 -0.5 0.7 0.7
Tinnitus: Yes, now most or all of the time 0.5 0.6 2.9 1.2 0.2 -0.6 -1.3 -1.7 -0.1 0.7 -0.8 -1.0 0.0 -0.6 -0.4 0.1 -0.6 -0.7 -0.9 -0.9 -1.2 -0.7 -0.9 -0.0 0.5 -0.1 -1.2 0.1 0.5 0.5 0.3 -0.2 1.3
Commuting to job workplace: Public transport 0.5 0.7 2.4 1.0 1.1 0.3 -0.0 0.6 0.5 0.9 0.3 1.5 0.0 0.3 -1.2 1.2 0.4 0.4 -0.0 -0.1 0.5 -0.8 0.5 1.0 1.2 1.0 0.8 1.1 0.1 1.2 0.1 1.2 0.8
Eye problems/disorders: Glaucoma 1.4 1.7 4.3 0.9 1.5 2.0 1.1 1.1 1.6 1.3 1.6 0.1 0.0 2.0 -0.7 1.1 1.7 1.3 0.8 1.5 1.0 -0.3 1.3 1.4 0.5 1.0 1.5 1.0 0.9 1.3 1.2 2.1 1.8
Medication: Blood pressure 0.9 1.6 3.7 -0.5 -1.7 -1.0 -1.3 -0.1 -1.3 -0.4 -1.6 -0.7 0.0 -1.0 1.8 -1.6 -0.9 -1.4 -1.6 -0.7 -1.9 -0.0 -1.8 -1.7 -1.9 -1.4 -1.6 -1.7 1.1 -1.3 0.3 -1.2 -0.6
Pain type(s) experienced in last month: Hip pain 0.6 0.8 3.2 -1.1 0.7 0.8 1.4 -0.0 0.9 0.2 0.3 -0.8 0.0 0.8 -0.7 0.5 -0.4 1.1 0.9 1.1 1.5 0.4 1.6 0.7 0.8 1.1 1.8 0.6 -0.9 0.6 -0.2 0.6 -0.6
Supplements: Fish oil (including cod liver oil) 3.3 4.3 8.6 -0.8 -2.1 -2.7 -2.6 -2.2 -2.4 -0.6 -2.9 -1.1 0.0 -2.7 1.6 -2.5 -1.0 -2.8 -2.9 -1.8 -1.8 0.0 -2.9 -2.3 -1.6 -2.7 -2.1 -2.0 1.0 -2.7 -2.0 -1.2 -1.8
High cholesterol (Self-reported) 3.2 5.7 23.0 -1.8 -2.2 -1.8 0.2 1.2 -1.0 -4.1 -1.4 -0.7 0.0 -1.8 0.8 0.1 -4.6 -0.4 0.5 1.2 0.1 0.4 -1.4 -0.4 -0.7 -3.5 -3.3 -2.2 -3.5 -4.2 -3.8 -4.8 -3.8
Medication: Bendroflumethiazide 0.5 0.8 3.9 -1.1 -0.9 -0.0 -0.3 -0.8 0.8 0.3 -0.4 -0.6 0.0 -0.0 1.5 -1.2 0.3 -0.7 -0.7 0.0 -1.0 1.7 -0.3 -1.2 -1.6 0.3 0.2 -0.4 1.5 0.0 2.0 0.7 0.5
Medication: Paracetamol 0.8 1.3 5.0 -1.7 0.1 0.4 1.7 -0.7 0.8 -1.2 0.6 1.0 0.0 0.4 -0.6 0.7 -2.0 1.2 1.4 1.7 1.8 1.1 1.2 0.6 0.5 0.4 1.1 0.1 -2.2 -0.8 -1.2 -0.4 -1.3
Medication: Lisinopril 1.4 1.8 3.9 -1.7 -1.8 -1.9 -1.4 -1.3 -0.9 -0.3 -1.7 1.0 0.0 -1.9 1.5 -1.8 -1.3 -2.0 -1.7 -1.6 -1.3 -0.1 -1.2 -1.9 -1.6 -0.6 0.2 -1.2 0.5 -1.4 0.0 -0.3 -1.4
Medication: Atorvastatin 1.0 1.3 4.5 -1.2 -1.6 -0.9 -0.5 0.3 -0.5 -1.4 -1.4 -0.9 0.0 -0.9 1.2 -1.1 -0.9 -0.7 -0.4 0.1 -1.2 0.9 -1.1 -1.3 -1.3 -1.8 -2.0 -1.6 -0.3 -1.3 -0.5 -2.1 -0.8
Illnesses of father: High blood pressure 1.2 1.4 5.1 -2.1 -1.6 0.5 1.3 1.7 0.2 -2.1 1.0 0.4 0.0 0.5 2.0 -0.5 -0.1 0.5 1.5 2.3 -0.1 0.5 0.9 -0.8 -1.9 0.5 0.6 -0.9 -0.4 -0.6 2.2 -0.9 -0.6
Alcohol drinker status: Never 0.3 0.4 2.2 1.5 -0.2 -0.5 -0.3 0.3 -0.0 -1.4 0.5 -1.2 0.0 -0.5 0.1 0.4 -0.3 -0.4 0.1 1.1 -0.3 0.9 0.4 0.2 0.0 0.7 0.9 0.5 0.0 0.3 1.0 0.4 0.1
Ever smoked 0.4 0.7 3.0 -1.7 -1.1 -1.0 -0.4 -0.2 -0.7 -0.3 -1.0 0.5 0.0 -1.0 0.8 -0.9 -0.2 -0.9 -0.8 -1.1 -0.1 -0.1 -0.6 -1.0 -0.7 -0.7 -0.1 -0.8 -0.1 -1.1 -0.8 -0.4 -1.5
Basal metabolic rate 0.2 0.9 6.2 1.0 -0.3 -0.4 -1.1 -0.1 -1.8 0.0 -0.8 -0.4 0.0 -0.4 0.3 -0.2 0.3 -0.6 -0.6 -0.8 -1.4 -2.5 -1.4 -0.3 -0.7 -1.5 -1.8 -1.0 0.7 -0.4 -0.2 -1.1 0.9
Leg fat percentage (left) 0.4 1.5 4.7 -1.3 -2.0 -1.1 -0.2 -0.5 -0.8 -1.4 -0.7 -0.1 0.0 -1.1 1.7 -1.6 -2.1 -0.9 -0.6 -0.5 -1.1 -0.8 -0.3 -1.8 -1.9 -0.6 -0.7 -1.7 -0.4 -1.1 -0.1 -2.0 -2.2
Arm fat-free mass (left) 0.1 0.6 5.6 1.4 0.3 -0.3 -1.0 0.1 -1.3 0.4 -0.6 -0.3 0.0 -0.3 -0.2 0.2 0.5 -0.5 -0.6 -0.8 -1.1 -2.4 -0.9 0.2 -0.1 -1.0 -1.3 -0.4 0.7 0.1 -0.2 -0.4 1.1
Number of operations (self-reported) 0.6 0.9 3.0 0.7 1.3 1.0 0.8 0.9 1.1 -0.2 0.0 0.6 0.0 1.0 -1.2 1.6 -0.4 1.0 1.1 0.8 1.4 1.7 0.2 1.4 1.0 -0.0 0.4 1.6 -0.4 -0.2 -0.2 1.1 0.7
Average weekly beer plus cider intake 0.4 0.5 6.0 0.7 -0.3 -1.2 -0.5 0.1 0.1 -0.8 -0.5 -0.6 0.0 -1.2 -0.5 -0.0 1.2 -0.4 -0.5 -0.1 -0.1 2.4 0.4 -0.0 0.4 -0.4 0.1 0.3 -0.7 -0.2 -0.9 0.1 -0.6
Irritability 0.5 0.8 3.7 -0.1 -0.4 0.7 1.5 1.8 0.3 -1.3 1.0 -0.4 0.0 0.7 0.5 0.4 -0.4 1.0 1.4 1.9 1.1 0.8 0.4 0.3 -0.6 -0.4 0.0 -0.6 -0.9 -0.8 -0.5 -0.7 -0.8
Risk taking 0.5 0.7 3.2 0.2 0.2 -0.5 -0.1 1.0 0.7 -1.8 -0.5 1.0 0.0 -0.5 -0.9 1.2 -1.0 0.1 0.5 0.9 0.2 1.8 -0.1 0.9 0.8 -0.6 -0.5 0.6 -1.3 -0.3 -1.3 -0.9 -0.3
Ever had prostate specific antigen (PSA) test 1.0 1.1 3.6 -0.3 -0.7 -1.0 -1.7 -0.7 -0.8 0.2 -1.3 0.3 0.0 -1.0 0.5 -1.0 0.7 -1.3 -1.4 -1.1 -1.3 1.1 -1.9 -1.0 -0.5 -1.8 -1.7 -0.8 0.9 -1.0 -1.2 -0.8 0.0
Fractured/broken bones in last 5 years 0.9 1.2 5.9 0.3 1.5 0.2 -0.3 -0.3 0.5 1.4 -0.4 -0.2 0.0 0.2 -1.4 0.8 0.6 0.0 -0.5 -1.1 0.8 1.4 1.4 1.0 1.4 1.6 1.9 2.1 0.6 1.5 0.3 2.4 0.4
Age started oral contraceptive pill 1.8 2.2 13.1 0.4 0.7 1.4 0.0 -0.1 1.1 2.4 0.9 -0.3 0.0 1.4 0.7 -0.6 2.2 0.1 -0.3 -0.2 -0.9 -0.4 0.7 -0.3 -0.6 1.9 0.9 0.3 2.9 2.6 3.6 2.5 2.6
Diastolic blood pressure, automated reading 0.5 1.5 6.5 -0.7 -2.0 -1.2 -0.6 -0.8 -0.8 -2.0 -0.5 1.0 0.0 -1.2 1.8 -1.3 -2.5 -1.2 -0.1 0.4 -1.1 -0.1 -1.0 -1.6 -2.0 -0.8 -0.4 -1.3 -0.1 -1.6 0.5 -1.2 -1.3
Ever depressed for a whole week 0.2 0.2 1.1 0.9 0.4 -0.2 -0.4 -1.1 0.8 -0.5 -0.2 0.7 0.0 -0.2 -0.5 0.5 0.1 -0.1 0.1 -0.5 0.1 0.9 -0.4 0.4 0.4 -0.4 -0.0 0.8 0.1 0.0 -0.0 0.4 0.4
Unable to work because of sickness or disability 1.4 1.9 5.7 1.2 2.2 0.9 0.4 -0.1 1.7 0.3 0.7 -0.3 0.0 0.9 -2.4 2.0 0.8 1.1 0.9 0.3 1.3 0.3 1.7 2.0 2.4 1.6 1.6 2.4 -0.6 1.7 0.2 1.7 0.9
Commuting to job workplace: Cycle 0.4 0.5 2.4 -0.5 -0.8 0.4 0.5 1.5 -0.4 -0.6 -0.1 -0.2 0.0 0.4 1.1 -0.2 -0.1 0.3 0.3 0.3 -0.3 0.1 -1.0 -0.3 -0.9 -1.1 -1.6 -1.5 0.1 -0.8 -0.2 -1.2 0.4
Myopia 1.1 1.6 5.9 -0.2 -1.1 -0.5 -1.6 -0.3 -0.4 1.1 -0.4 1.3 0.0 -0.5 1.8 -1.7 1.6 -1.5 -1.8 -1.3 -2.3 0.3 -1.1 -1.7 -1.8 -0.5 -1.5 -1.2 2.4 0.3 1.3 -0.2 0.9
Vascular/heart problems diagnosed by doctor 0.7 1.9 6.8 1.2 2.2 0.7 0.7 -0.7 1.0 1.2 1.1 -0.4 0.0 0.7 -2.6 1.9 1.0 1.2 0.9 0.3 1.7 -0.9 1.6 2.0 2.6 1.3 1.2 1.9 -1.2 1.4 -1.4 0.9 0.5
Cholesterol lowering medication 1.0 1.5 6.8 -0.8 -1.4 -1.1 -0.0 1.7 -0.3 -2.6 -0.6 0.1 0.0 -1.1 0.8 -0.0 -2.6 -0.4 0.5 0.5 -0.3 1.0 -0.5 -0.5 -0.8 -1.4 -1.5 -0.8 -1.5 -1.7 -0.9 -2.4 -2.1
Medication: Omeprazole (e.g. Zanprol) 1.6 1.9 6.2 0.0 1.2 2.0 1.4 0.8 2.5 0.9 1.4 0.8 0.0 2.0 -0.5 0.8 1.0 1.7 1.4 1.3 0.5 1.2 1.8 0.9 0.5 2.1 1.2 1.3 0.5 2.1 2.3 1.1 1.5
Pain experienced in last month 0.8 1.4 4.4 1.7 -0.2 -1.7 -2.1 -0.3 -1.9 0.7 -0.9 -1.0 0.0 -1.7 -0.3 -0.1 0.7 -1.8 -1.9 -2.1 -1.1 -1.6 -1.3 -0.2 0.4 -1.0 -1.1 0.0 0.7 -0.5 -1.1 0.1 0.0
Supplements: Calcium 0.6 0.7 3.8 -0.1 0.0 -1.1 -0.6 -1.9 -0.2 0.4 -0.5 1.4 0.0 -1.1 -0.5 -0.4 -0.9 -0.8 -1.1 -0.9 0.7 0.2 -0.1 -0.3 0.7 0.3 1.1 0.6 -0.4 -0.4 -1.3 0.7 -1.6
Basal cell carcinoma (self-reported) 0.9 1.0 3.7 -0.7 -1.1 -1.1 -0.2 -0.3 -1.2 -1.4 -1.3 -0.8 0.0 -1.1 0.5 -0.3 -1.9 -0.6 -0.2 -0.7 0.1 -0.6 -1.0 -0.4 -0.5 -1.5 -1.0 -0.8 -1.0 -1.4 -1.4 -1.5 -1.7
Heart attack/myocardial infarction (self-reported) 1.2 1.5 3.9 -0.4 -2.0 -1.8 -1.0 -0.9 -1.2 -0.8 -1.2 1.2 0.0 -1.8 1.7 -1.6 -0.8 -1.8 -1.2 -0.9 -1.1 -1.0 -0.6 -1.9 -1.5 -0.7 -0.2 -1.4 0.3 -1.0 0.1 -0.9 -1.9
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 1.3 -0.6 0.2 0.3 0.0 -0.5 -0.2 0.1 0.2 1.1 0.0 0.3 0.1 0.0 -1.1 0.1 -0.1 -0.4 0.2 0.0 -0.3 0.1 -0.1 0.0 0.0 -0.0 0.5 -0.1 0.2 0.6 0.3
Heart disease (siblings) 1.0 1.3 5.4 -1.2 -1.5 -0.2 0.9 0.9 -0.9 -2.0 0.1 -1.8 0.0 -0.2 1.2 -0.6 -1.6 0.3 0.6 0.8 -0.2 0.1 -0.2 -0.7 -1.3 -1.0 -1.1 -1.6 -1.3 -1.3 -0.6 -2.3 -1.7
Alcohol drinker status: Previous 0.6 0.7 3.4 -0.3 0.8 0.7 0.8 1.3 0.9 -0.7 0.1 1.8 0.0 0.7 -1.0 0.9 -0.3 1.0 1.0 0.2 1.0 0.9 0.9 0.9 1.2 0.8 0.8 1.1 -1.1 0.6 -0.3 -0.0 -0.0
Pack years of smoking 0.7 1.1 3.8 -0.0 0.5 0.6 1.0 1.9 1.3 -1.5 1.0 0.8 0.0 0.6 -0.4 1.4 -0.5 0.9 1.6 1.7 0.8 0.5 1.6 1.3 0.4 1.1 1.3 1.2 -0.5 0.6 1.5 0.7 0.3
Impedance of whole body 0.4 2.2 8.6 0.7 1.3 0.6 1.8 1.3 0.5 -0.6 1.7 -0.3 0.0 0.6 -2.1 2.0 -0.3 1.8 1.6 1.5 2.5 0.4 1.6 1.9 2.2 1.1 1.7 1.5 -2.9 0.3 -1.9 -0.2 -1.1
Leg fat mass (left) 0.5 2.0 4.3 -0.8 -2.1 -1.5 -0.9 -0.6 -1.6 -1.4 -1.1 -0.3 0.0 -1.5 1.8 -1.7 -1.8 -1.4 -1.0 -1.0 -1.7 -1.7 -1.1 -1.9 -2.0 -1.1 -1.4 -2.0 0.1 -1.1 -0.0 -2.0 -1.5
Arm predicted mass (left) 0.1 0.6 5.8 1.1 0.2 -0.2 -0.8 0.2 -1.2 0.1 -0.5 -0.2 0.0 -0.2 -0.2 0.3 0.4 -0.3 -0.3 -0.7 -0.9 -2.4 -0.9 0.2 -0.2 -1.1 -1.3 -0.5 0.5 -0.1 -0.4 -0.6 0.9