Hub : Genes

ACOX2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.5197 0.0973 1.8e-05 0.015 NA 0.086 NA 0.013 0.09400 NA 0.00054 NA 0.1000
2 GTEx Heart Atrial Appendage 0.1280 0.0550 2.9e-03 0.003 NA 0.016 NA -0.005 0.22000 NA 0.05900 NA 0.6900
3 GTEx Muscle Skeletal 0.1103 0.0482 4.8e-03 0.003 NA 0.004 NA 0.000 0.14000 NA 0.11000 NA 0.3400
4 METSIM Adipose 0.0624 0.0240 4.5e-04 0.021 0.022 0.010 0.024 0.013 0.00038 0.00024 0.01100 0.00013 0.0044
5 TCGA Colon Adenocarcinoma 0.1700 0.0620 3.7e-04 0.003 0.039 0.054 NA 0.013 0.22000 0.00260 0.00047 NA 0.0580
6 TCGA Brain Lower Grade Glioma 0.0423 0.0205 7.9e-03 -0.002 0.020 -0.002 NA -0.002 0.88000 0.00240 0.56000 NA 0.9100
7 TCGA Thyroid Carcinoma 0.0620 0.0300 2.2e-03 -0.003 0.014 0.021 NA -0.002 0.81000 0.01600 0.00330 NA 0.6300

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.5 0.8 2.5 0.9 0.3 -0.5 -0.4 -1.1 1.6 0.9
Bipolar Disorder or Schizophrenia 0.5 1.1 3.0 0.0 1.1 -0.7 -0.1 -0.6 1.7 1.7
Depressed Affect (Nagel 2018) 0.6 1.3 2.2 0.9 -0.8 1.0 -1.5 -1.5 -1.4 -0.6
Depression (Nagel 2018) 0.3 0.4 1.2 0.1 1.1 -0.5 0.5 0.7 -0.7 -0.6
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.2 1.1 1.0 -0.3 0.6 0.5 -0.5 0.3
Neuroticism (Nagel 2018) 0.5 1.1 2.8 0.6 -0.9 -0.2 -1.7 -1.4 -1.2 -0.5
Schizophrenia (2018) 0.3 0.7 1.8 -0.9 1.1 -0.5 0.4 -0.1 0.8 1.4
Schizophrenia vs Biploar Disorder 1.1 1.4 3.2 -1.8 0.6 -0.5 -1.2 0.8 -1.7 -1.1
Worry (Nagel 2018) 1.1 2.4 10.3 0.3 -1.1 -1.2 -3.2 -1.8 -0.7 -0.3
Alzheimer’s Disease (in mother) 0.9 1.0 2.5 -0.9 -0.3 0.3 1.0 0.7 1.5 1.6
Alzheimer’s Disease (in father) 0.7 0.8 2.0 0.1 0.8 0.2 0.9 0.7 1.4 1.2
Alzheimer’s Disease (including proxy) 1.6 2.4 6.4 -0.5 0.8 0.5 1.6 0.8 2.4 2.5
Crohns Disease (2017) 0.3 0.7 1.5 0.6 0.6 0.5 1.2 -0.2 1.0 1.1
Irritable Bowel Disease (IBD) 0.3 0.8 2.8 0.6 1.2 0.5 -0.1 0.2 1.0 1.7
Ulcerative Colitis (UC) 0.6 1.1 3.2 0.2 1.6 0.3 -0.9 0.7 0.7 1.8
Major Depression (MDD) 0.5 0.6 2.0 -0.4 0.3 -1.4 -0.5 0.9 -0.6 -0.6
Reaction Time 0.6 1.2 3.6 -1.9 -0.7 -0.7 1.2 -0.4 -1.0 -1.1
Verbal and Numeric Reasoning (VNR) 1.1 2.7 9.9 0.3 3.1 0.2 2.1 1.7 0.3 1.2
Breast Cancer 0.1 0.2 0.6 -0.1 0.2 0.8 0.4 0.4 0.1 -0.2
Ovarian Cancer 0.8 1.1 3.0 -1.3 -0.5 -0.6 1.0 -0.5 -1.0 -1.7
Prostate Cancer 0.2 0.3 1.1 0.7 -1.0 -0.3 0.2 -0.3 -0.2 -0.5
Age at First Birth 0.6 0.9 1.9 0.5 1.4 0.6 1.3 0.7 0.7 1.1
Bipolar Disorder (2011) 0.4 0.4 1.2 1.1 -0.2 0.7 -1.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.9 1.3 2.2 -1.4 -1.5 -0.1 -0.8 -0.9 -1.5 -1.0
Coronary Artery Disease (CAD) 0.5 0.6 1.6 -1.3 -0.9 0.1 -0.4 0.2 -1.0 -0.6
Crohns Disease (2012) 0.8 1.2 5.0 -0.2 -1.1 -0.6 -0.4 -2.2 -0.2 -1.3
Mean Putamen Volume 1.2 1.4 6.1 -0.5 -0.2 -2.5 0.8 -0.9 -1.3 0.1
Fasting Glucose 0.9 1.1 3.8 -0.2 1.3 -0.8 0.8 -1.9 1.0 -0.3
HbA1C 2.1 2.3 7.5 -2.3 -0.7 -1.3 2.7 0.3 -0.2 -1.2
HDL Cholesterol 0.3 0.5 1.2 0.1 -0.6 1.1 0.2 -0.6 0.6 1.1
LDL Cholesterol 1.0 1.6 4.2 -0.0 -0.4 1.0 0.0 -2.1 1.7 1.7
Lupus 3.0 4.6 19.2 -0.7 4.4 -1.4 0.9 2.8 0.4 1.2
Neuroticism (2016) 0.5 0.8 3.1 -0.4 -0.0 -1.8 0.1 0.1 -1.1 -1.1
Primary Biliary Cirrhosis 1.0 1.4 4.6 0.4 2.1 0.4 1.4 0.3 1.3 1.1
Rheumatoid Arthritis 0.9 1.2 2.9 -0.9 -1.5 -0.4 -0.5 -1.7 -0.8 -1.2
Schizophrenia (2014) 0.3 0.7 2.3 -0.5 1.5 -0.2 -0.2 -0.7 0.7 1.1
Triglycerides 0.4 0.6 2.7 -0.3 -0.2 -1.0 0.3 -1.6 -0.4 -0.7
Type 2 Diabetes (T2D) (2012) 2.0 2.3 4.6 0.6 1.7 1.4 1.1 1.1 2.1 2.1
Ulcerative Colitis 0.6 0.8 2.9 0.4 1.0 -0.4 -1.7 -0.5 0.6 0.9
Blood Eosinophil Count 0.3 2.6 7.1 1.0 2.7 0.7 0.5 1.4 2.2 1.7
Blood Platelet Count 2.9 33.3 102.0 -0.7 -10.1 1.5 -8.3 -6.4 -3.9 -1.6
Blood Red Count 1.1 10.7 53.1 1.4 7.3 -2.2 0.9 2.5 1.3 2.5
Blood White Count 0.1 0.8 3.0 -1.4 -0.2 0.6 1.7 0.2 0.3 0.6
Heel T-Score 0.8 6.4 13.9 -2.2 -1.9 -3.5 -1.3 -0.4 -3.7 -2.9
BMI 0.4 2.2 9.0 -0.8 -3.0 -0.2 0.9 -2.1 0.2 0.8
Height 0.9 16.5 44.6 0.5 6.2 2.8 6.7 2.6 2.6 3.2
Waist Hip Ratio (WHR) 0.4 1.7 8.0 -0.5 2.8 0.8 0.5 0.4 0.5 1.6
Systolic Blood Pressure 0.6 3.1 9.2 -3.0 -2.6 0.6 0.9 -1.4 -1.1 -1.2
Smoking Status 0.5 1.3 2.9 1.7 -0.3 1.3 -1.6 -0.2 0.8 1.0
Allergy or Eczema 0.2 0.6 1.0 0.9 0.5 1.0 -0.9 -1.0 -0.3 0.5
Cardiovascular Disease 0.5 1.6 5.3 -0.4 -2.1 0.4 -0.4 -2.3 0.4 0.9
Hypothyroidism (self reported) 0.8 1.7 5.7 1.9 2.4 -0.3 -0.1 0.6 0.9 1.3
Respiratory disease 0.3 0.7 3.0 -0.4 0.5 -0.9 0.2 1.7 -0.6 0.1
Type 2 Diabetes (T2D) (2018) 0.6 1.0 3.0 0.9 1.7 -0.2 0.4 -0.2 1.6 0.8
Lung FEV1/FVC ratio 0.3 1.7 4.2 0.2 -2.1 -0.9 -1.0 -1.9 -0.3 -1.5
Lung FVC 1.1 5.8 12.4 -0.2 -3.5 -1.1 -2.3 -1.6 -2.8 -3.4
Neuroticism 0.7 1.7 6.4 1.1 -1.1 0.1 -1.7 -2.5 -0.7 -0.3
Chronotype (morning person) 0.3 0.6 1.2 0.1 0.8 -1.1 0.7 0.9 -0.3 -0.9
Hair Pigment 0.0 1.0 2.6 1.0 0.9 0.5 -1.6 1.1 0.7 0.7
Tanning 0.1 0.9 3.4 -0.1 -0.9 -0.2 0.9 0.0 -1.8 -1.2
Hand grip strength (left) 0.2 0.6 1.6 -0.3 0.4 -0.1 1.0 0.5 -1.3 -1.0
Number of treatments/medications taken 0.3 0.6 2.9 -0.1 -1.7 0.4 0.1 -0.8 0.3 -0.3
Average weekly spirits intake 1.9 2.3 6.3 1.6 0.1 2.5 -1.3 -0.4 2.0 1.3
Sensitivity / hurt feelings 0.5 0.9 3.6 1.4 -0.4 1.9 0.1 -0.6 0.1 0.5
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.3 1.0 0.6 0.4 1.1 -0.5 0.6 0.2
Hearing difficulty/problems: Yes 0.2 0.2 0.7 0.3 -0.6 -0.3 -0.6 0.2 -0.2 -0.9
Relative age of first facial hair 0.2 0.4 2.4 -0.4 -1.5 0.5 0.2 -0.0 -0.1 -0.2
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.4 1.0 0.5 0.4 0.1 0.5 1.2 0.8
Ever used hormone-replacement therapy (HRT) 3.2 4.1 12.8 1.6 -3.6 -0.8 -1.9 -2.3 -1.3 -1.2
Ever had hysterectomy (womb removed) 1.1 1.3 3.6 1.2 -1.5 0.6 -1.9 -1.0 0.3 -0.4
Systolic blood pressure, automated reading 0.9 2.5 7.7 -2.6 -2.8 -0.3 0.7 -0.6 -0.7 -1.3
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 2.5 -1.0 -1.2 -0.2 0.3 -1.6 0.3 -0.2
Angina 1.0 1.3 3.5 -0.8 -1.9 -1.2 -0.4 -0.7 -1.0 -1.4
Medication for hormone replacement therapy 0.1 0.1 0.2 0.5 0.2 0.3 0.2 -0.2 -0.1 -0.3
Vitamin and mineral supplements 0.7 1.0 3.0 -0.9 -0.7 -0.8 -0.5 -0.3 -1.7 -1.2
Supplements: Zinc 0.5 0.5 1.1 -0.2 0.6 -0.9 -1.1 0.9 0.4 -0.4
Medication: Co-codamol 2.1 2.4 5.6 -1.0 -2.1 -1.2 -0.4 -2.4 -1.0 -1.9
Medication: Metformin 0.5 0.7 1.9 -0.2 1.3 -0.9 1.4 0.4 -0.3 -0.2
Diabetes (father) 0.1 0.1 0.2 0.0 -0.0 0.5 -0.1 -0.4 0.2 -0.3
Diabetes (mother) 1.0 1.2 5.5 0.4 0.1 -0.6 -1.5 -2.3 -0.3 -0.4
Severe depression (siblings) 1.4 1.5 6.4 -0.3 1.2 -0.8 2.5 -1.2 0.3 0.7
Pack years adult smoking proportion 0.4 0.6 1.2 -1.0 -0.5 -0.2 -0.4 -1.0 -1.1 -0.8
Impedance of leg (right) 0.4 1.7 5.5 0.3 2.3 0.9 -1.4 1.9 -0.3 0.3
Leg fat-free mass (left) 0.3 1.5 5.4 0.1 -0.2 0.8 2.3 -1.5 0.9 1.1
Trunk fat percentage 0.3 1.1 2.7 -0.2 -1.2 0.8 1.6 -0.9 0.8 1.1
Hand grip strength (right) 0.2 0.6 1.9 -0.3 0.5 1.4 0.6 0.1 -1.1 -0.5
Townsend deprivation index at recruitment 1.0 1.4 3.7 -1.0 -0.7 -1.9 -0.5 -1.2 -1.4 -1.0
Current tobacco smoking 0.8 1.2 3.5 0.4 -1.5 0.5 -1.9 -1.6 -0.5 -0.2
Average weekly fortified wine intake 0.5 0.6 2.3 -0.2 1.5 -0.2 1.1 0.2 0.2 0.6
Maternal smoking around birth 0.5 0.7 1.5 0.1 0.9 -0.0 -1.2 1.1 -0.3 -1.0
Fed-up feelings 0.7 1.3 3.2 -1.1 0.3 -0.4 -1.1 1.0 -1.8 -1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 4.2 -1.2 1.4 -1.3 2.1 1.4 0.0 -0.1
Relative age voice broke 0.4 0.7 1.3 -0.0 -0.9 1.1 -0.8 -0.7 1.1 0.7
Taking other prescription medications 0.4 0.6 2.3 -0.7 -0.9 -1.5 0.2 -0.2 -0.7 -0.2
Age when periods started (menarche) 1.0 2.5 9.9 -0.4 3.1 -1.7 0.1 1.9 -0.4 0.4
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.8 0.9 -0.0 -0.5 -0.2 -0.0 -0.5 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.7 4.0 -1.8 0.2 -2.0 0.8 -0.2 -1.4 -1.4
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 3.4 0.5 1.8 0.6 0.0 1.4 -0.3 0.6
Qualifications: CSEs or equivalent 0.2 0.3 0.8 0.9 -0.9 -0.4 -0.3 -0.6 0.0 0.1
Serious illness, injury or assault to yourself 0.1 0.1 0.2 -0.5 -0.3 -0.1 -0.4 0.2 -0.3 -0.2
High blood pressure 0.7 1.8 4.5 -2.1 -1.5 -1.3 0.2 -1.1 -1.5 -1.0
Hayfever, allergic rhinitis or eczema 0.2 0.4 1.2 0.5 0.8 1.1 0.3 -0.6 -0.2 0.5
Multivitamins +/- minerals 0.9 1.1 2.8 -0.9 1.2 -0.0 1.3 0.0 1.7 1.2
Stomach or abdominal pain in last month 0.7 0.8 4.8 0.6 -0.3 -0.7 -2.2 -0.0 0.0 0.5
Supplements: Glucosamine 0.9 1.1 2.7 1.6 0.5 1.6 0.4 0.9 1.1 0.6
Diverticular disease/diverticulitis (self-reported) 1.3 1.5 5.9 -0.4 -1.1 -2.4 -0.7 -1.6 -0.1 0.3
Medication: Atenolol 0.3 0.4 0.8 -0.5 -0.9 -0.7 0.3 -0.4 -0.2 -0.9
Medication: Levothyroxine sodium 0.8 1.3 3.0 1.0 1.6 -1.4 0.7 1.7 0.2 0.4
Sitting height 1.1 8.0 19.6 1.8 4.2 2.7 4.4 2.7 0.5 1.0
Chronic bronchitis/emphysema (father) 1.8 2.1 4.6 -1.7 -0.5 -2.1 -1.2 1.0 -1.6 -1.5
High blood pressure (mother) 2.0 2.9 8.5 -0.0 -2.1 0.1 -2.1 -2.9 -1.4 -0.7
Body mass index (BMI) 0.3 1.3 4.3 0.0 -2.1 0.1 0.7 -1.8 0.6 0.6
Impedance of leg (left) 0.4 2.0 6.4 -0.1 2.5 0.7 -0.9 2.4 -0.6 -0.0
Leg predicted mass (left) 0.3 1.4 5.1 0.2 -0.2 0.7 2.2 -1.5 0.8 1.0
Trunk fat mass 0.3 1.3 4.1 -0.3 -0.7 1.0 2.0 -1.0 1.0 1.3
Waist circumference 0.4 1.4 2.7 -0.1 0.0 1.0 1.3 -1.5 1.3 1.6
Number of incorrect matches in round 0.2 0.4 1.1 -0.3 -0.9 -1.0 -0.1 -0.4 -0.5 -0.4
Past tobacco smoking 0.9 1.7 5.7 -2.4 0.6 -1.6 1.1 -0.2 -1.1 -0.7
Alcohol usually taken with meals 1.8 2.9 8.8 -0.2 1.2 1.4 3.0 1.3 1.9 1.7
Nervous feelings 0.7 1.3 3.8 2.0 -0.1 -0.6 -1.7 -1.5 0.3 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.5 -0.6 -0.1 0.0 0.4 -1.2 0.3 0.2
Hearing difficulty/problems with background noise 0.4 0.7 2.7 0.1 -0.1 1.6 1.3 0.4 0.3 0.0
Hair/balding pattern: Pattern 2 0.3 0.3 0.8 -0.4 -0.8 0.1 -0.5 -0.6 0.4 0.9
Had menopause 0.8 1.0 2.9 1.0 -1.3 -0.4 -1.7 -0.1 -0.7 -0.8
Had other major operations 0.9 1.2 4.0 -0.1 -0.6 -0.8 -0.4 0.6 -1.6 -2.0
Forced vital capacity (FVC) 0.2 0.9 3.0 -0.5 -0.4 0.6 0.8 -0.6 -1.7 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.0 -1.0 0.6 -0.9 -0.2 -0.8 -0.3 -0.5
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 3.8 -0.7 -0.6 -0.3 -1.1 -0.1 -1.9 -1.3
Qualifications: None of the above 0.9 1.9 3.7 -0.6 -1.9 -0.6 -1.9 -1.0 -1.5 -1.5
Financial difficulties in last 2 years 0.3 0.4 1.3 -0.0 0.1 1.1 0.1 -0.8 0.6 0.5
Mouth/teeth dental problems 0.9 1.4 4.9 -2.2 0.7 -1.4 1.0 0.8 0.5 0.6
Heart attack 0.6 0.8 2.6 0.0 -1.6 1.1 -0.0 -1.0 0.9 0.3
Allergy 0.1 0.2 0.8 -0.2 0.1 -0.8 -0.2 0.3 0.9 0.2
Pain all over the body in last month 1.7 1.9 3.4 -1.5 -1.6 -1.3 -0.8 -1.8 -1.2 -1.1
Diabetes (self-reported) 0.6 0.9 2.6 -1.6 1.0 -1.1 0.9 0.5 0.1 -0.5
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 1.2 1.0 0.2 0.5 0.6 -1.1 0.8 0.8
Medication: Ramipril 2.6 3.3 7.4 -1.2 -2.3 -1.9 -0.3 -1.6 -1.6 -2.7
Medication: Simvastatin 1.0 1.5 4.7 -0.3 -2.2 0.9 -1.0 -2.0 -0.3 -0.4
Fluid intelligence score 0.7 1.5 4.7 -0.0 2.2 0.7 1.5 0.8 0.5 1.4
Illnesses of siblings 0.5 0.7 2.5 -0.0 1.1 -0.3 0.9 1.6 0.1 -0.1
Neuroticism score 0.6 1.2 4.2 1.6 -0.6 0.4 -1.2 -2.0 -0.4 -0.0
Weight 0.3 1.7 5.7 -0.1 -0.1 1.0 2.4 -1.3 1.1 1.4
Impedance of arm (right) 0.1 0.5 1.2 -0.5 0.7 0.7 0.6 1.1 0.5 0.6
Arm fat percentage (right) 0.5 1.9 4.3 -0.3 -2.1 0.6 1.3 -2.1 1.1 1.3
Trunk fat-free mass 0.2 1.3 5.1 0.0 1.5 0.6 2.2 -0.6 0.4 1.0
Hip circumference 0.4 1.7 3.3 0.5 -0.0 0.8 1.8 -1.3 1.6 1.8
Time employed in main current job 0.6 0.6 2.3 -1.2 -1.5 -0.7 0.1 -0.4 -0.3 -0.3
Alcohol intake versus 10 years previously 0.8 1.2 2.7 1.3 1.6 0.3 -1.2 0.7 0.3 1.5
Father’s age at death 0.9 1.2 6.5 -0.9 -0.5 0.3 2.6 0.8 0.2 0.4
Worrier / anxious feelings 0.3 0.6 1.8 0.5 -0.2 -0.0 -1.4 -1.3 -0.1 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.5 -0.3 -0.4 -0.7 0.2 -0.6 -0.5 0.0
Falls in the last year 0.6 0.9 3.6 -0.9 -0.2 1.0 1.9 -0.7 0.1 0.2
Hair/balding pattern: Pattern 3 0.9 1.4 3.5 -1.0 1.4 -0.6 0.4 1.9 -1.5 -0.4
Number of live births 0.4 0.6 2.1 -0.1 -1.5 1.2 -0.4 -0.2 -0.3 0.1
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 2.3 -0.6 -1.5 -0.0 0.6 -1.4 -1.4 -1.5
Pulse rate 1.4 2.3 3.5 -1.3 1.2 -1.9 1.7 1.9 -1.5 -1.1
Happiness 0.2 0.3 0.7 0.8 0.8 0.3 -0.5 -0.1 0.3 0.3
Noisy workplace 1.4 1.8 4.9 -0.1 -2.2 -0.6 -1.5 -0.1 -1.0 -2.0
Qualifications: A levels/AS levels or equivalent 1.9 4.1 9.1 1.2 2.1 2.4 1.3 0.9 2.3 3.0
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.7 0.1 0.1 -0.1 0.5 -0.4 -0.0 0.9
Mouth/teeth dental problems: Dentures 0.6 1.0 2.3 1.5 -0.7 0.4 -1.0 -1.2 -0.7 -1.2
Asthma 0.2 0.5 1.7 -0.7 0.8 -0.3 0.3 1.3 -0.5 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.0 0.9 -0.9 1.0 -0.6 -0.9 -0.1 -0.7
Medication: Cholesterol lowering 1.0 1.5 4.7 -0.2 -1.8 0.6 -1.2 -2.2 0.8 -0.1
Depression (self-reported) 1.0 1.2 4.1 0.7 2.0 0.6 0.5 1.3 -1.1 -0.8
Medication: Lansoprazole 0.5 0.6 2.7 1.6 0.4 0.7 -0.2 -0.3 0.8 0.5
Prospective memory result 0.6 0.8 2.1 0.1 -0.4 1.0 -1.5 0.8 -0.3 -1.2
Lung cancer (father) 0.3 0.4 1.4 -0.3 -0.2 1.2 0.8 0.5 0.3 -0.2
Illnesses of mother 1.1 1.4 2.7 1.2 1.6 0.3 1.0 1.5 1.0 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.8 3.8 -0.9 -1.3 -0.9 0.3 -1.2 -1.9 -1.9
Pulse wave Arterial Stiffness index 1.3 1.5 2.8 -0.7 1.1 -1.4 0.7 1.2 -1.5 -1.7
Impedance of arm (left) 0.1 0.3 0.8 -0.4 0.5 0.7 0.5 0.9 0.1 0.2
Arm fat mass (right) 0.4 1.7 3.8 -0.4 -1.6 0.6 1.9 -1.8 0.8 1.0
Trunk predicted mass 0.3 1.5 5.6 0.1 1.7 0.8 2.4 -0.5 0.5 1.1
Standing height 0.6 6.2 17.2 -0.3 4.1 2.0 4.2 1.1 1.0 1.9
Length of working week for main job 0.6 0.6 1.7 0.3 -0.8 0.6 -1.2 -1.3 -0.4 0.4
Exposure to tobacco smoke at home 0.1 0.1 0.4 0.2 0.4 -0.4 0.6 -0.3 0.3 -0.3
Breastfed as a baby 0.9 1.2 3.3 0.4 1.2 0.5 1.1 1.8 0.2 1.3
Tense / ‘highly strung’ 1.2 2.0 8.6 0.3 -0.9 -0.8 -2.9 -1.1 -0.8 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 4.2 0.2 0.8 -0.9 2.0 0.7 -0.1 -0.4
Hair/balding pattern: Pattern 4 0.3 0.7 2.6 0.3 -1.1 0.3 0.8 -1.6 0.6 -0.2
Birth weight of first child 1.4 2.5 5.6 0.7 1.4 2.4 2.4 -0.8 0.9 1.6
Peak expiratory flow (PEF) 0.1 0.3 0.8 -0.2 -0.8 -0.9 -0.0 -0.6 -0.6 -0.2
Pulse wave reflection index 0.2 0.2 0.6 0.2 0.1 -0.4 -0.6 0.1 -0.6 -0.8
Ever highly irritable/argumentative for 2 days 3.8 4.6 8.6 -2.9 -1.7 -2.5 1.3 -0.4 -2.6 -2.4
Loud music exposure frequency 0.2 0.2 0.8 0.9 0.2 0.5 -0.0 -0.5 0.2 0.1
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 3.2 -0.3 0.9 0.8 1.5 -0.3 1.8 1.6
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.3 0.8 -0.4 -0.3 -0.7 -0.4 -1.1 -0.7
Blood clot in the leg (DVT) 0.2 0.3 1.4 0.1 -1.2 0.3 0.5 -0.4 0.0 -0.0
Medication: Paracetamol 0.3 0.6 1.4 0.3 0.3 -0.9 1.0 0.2 0.7 1.2
Headache pain in last month 1.5 2.6 7.0 1.5 0.7 -0.4 0.3 -1.6 2.4 2.6
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 4.5 0.9 2.1 0.4 0.0 1.8 -0.2 0.2
Glaucoma (self-reported) 1.4 1.6 3.1 -1.4 0.9 -1.6 1.2 1.1 -1.8 0.2
Gout (self-reported) 0.3 0.4 1.2 -0.3 -1.1 -0.6 1.1 -0.4 -0.0 -0.4
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 3.4 0.5 1.8 -1.1 0.1 1.4 0.4 0.7
Medication: Amlodipine 0.2 0.3 1.4 -0.1 -0.4 -0.3 -1.2 0.5 -0.2 -0.3
Medication: Ventolin 100micrograms inhaler 0.9 1.1 2.8 -0.9 -1.0 -1.7 0.6 0.9 -1.1 -1.0
Birth weight 0.8 1.8 4.0 0.8 1.3 2.0 1.7 -0.6 1.2 1.3
Chronic bronchitis/emphysema (mother) 0.7 0.8 3.2 0.1 -0.1 0.4 -0.8 0.1 -1.8 -1.3
High blood pressure (siblings) 1.2 1.8 4.9 0.3 -1.5 2.0 -0.4 -2.2 0.0 1.0
Forced vital capacity (FVC), Best measure 0.4 1.3 4.1 -1.1 -0.8 -0.7 0.7 -0.9 -2.0 -1.4
Body fat percentage 0.2 1.0 1.7 -0.1 -1.1 0.8 1.3 -0.9 0.9 1.3
Leg fat percentage (right) 0.1 0.5 1.3 -0.1 -0.7 0.6 -0.1 -0.7 0.8 1.2
Arm fat-free mass (right) 0.1 0.8 2.9 0.0 1.2 0.5 1.7 -0.4 0.1 0.6
Exposure to tobacco smoke outside home 0.2 0.3 0.7 0.7 -0.1 0.1 -0.9 -0.7 0.2 -0.4
Comparative body size at age 10 1.1 2.9 11.4 0.0 -3.4 0.7 -0.8 -1.9 -1.7 -1.2
Number of full brothers 0.4 0.5 1.5 0.1 1.2 -0.3 -0.4 -0.0 -1.1 -0.3
Worry too long after embarrassment 0.3 0.6 3.3 0.0 0.2 -0.5 1.8 -0.2 0.5 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 2.1 1.4 1.2 -0.4 1.1 -0.3 1.3 0.1
Wheeze or whistling in the chest in last year 0.6 1.0 3.5 -1.0 0.2 -1.9 0.4 0.9 -0.9 0.9
Number of children fathered 0.2 0.2 0.8 0.5 -0.1 0.9 0.3 -0.4 0.1 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.6 1.4 0.7 -0.5 1.2 -1.0 0.0 1.1 0.4
Age at first live birth 1.7 3.0 5.7 0.7 2.2 2.3 2.4 0.2 1.4 1.6
Pulse wave peak to peak time 1.0 1.2 2.6 0.6 -0.8 1.4 -0.3 -1.0 1.3 1.6
Health satisfaction 0.7 0.9 4.7 0.1 -0.8 -0.4 2.2 -0.7 0.6 0.2
Shortness of breath walking on level ground 0.7 0.9 2.3 -1.5 0.4 0.0 1.4 1.0 -0.7 -0.7
Qualifications: College or University degree 1.5 4.8 11.4 1.2 1.1 3.4 1.6 -1.4 3.0 2.5
Eye problems/disorders: None of the above 1.3 1.5 2.9 1.2 -1.0 1.7 -0.9 -1.4 1.4 0.4
Mouth/teeth dental problems: Loose teeth 1.2 1.4 3.5 1.9 -1.3 0.8 -1.8 -0.9 0.4 -0.0
Emphysema/chronic bronchitis 1.1 1.3 5.3 -0.4 -0.2 -2.3 -0.2 0.8 -1.2 -1.1
Medication for pain relief, constipation, heartburn 0.8 1.4 5.4 0.6 2.3 0.8 -0.6 1.3 0.3 1.2
Neck or shoulder pain in last month 3.4 4.8 19.8 -2.6 -0.1 -4.4 0.8 0.4 -2.4 -0.9
Medication: Blood pressure 1.7 3.0 9.9 -1.4 -3.1 -1.2 0.1 -1.9 -0.9 -1.8
Angina (self-reported) 1.1 1.4 2.7 -1.0 -1.6 -1.5 -0.5 -0.5 -1.1 -1.4
Migraine (self-reported) 0.4 0.5 0.8 0.4 0.6 -0.9 0.6 0.8 -0.9 -0.4
Medication: Ibuprofen 0.3 0.3 1.2 0.6 -0.3 0.6 -0.3 -1.1 0.3 -0.1
Medication: Allopurinol 0.3 0.4 1.3 -0.3 -1.1 -0.6 0.4 -0.9 -0.1 -0.4
Medication: Omeprazole 0.7 0.9 2.6 -0.0 0.1 -1.0 -1.6 -0.4 -1.2 -1.0
Medication: Seretide 50 evohaler 1.9 2.2 4.8 -2.0 1.0 -0.5 2.2 1.7 -0.8 -1.1
Mean time to correctly identify matches 1.0 1.8 4.3 -2.1 -1.2 -1.3 1.3 -0.8 -1.1 -1.4
Heart disease (mother) 0.5 0.6 2.3 -1.5 0.2 -0.6 0.4 0.5 -0.4 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 2.1 0.3 -1.4 -0.8 -1.4 -1.1 0.0 -0.1
Whole body fat mass 0.3 1.2 2.3 -0.0 -1.0 0.9 1.5 -1.4 0.9 1.2
Leg fat mass (right) 0.2 0.8 1.8 -0.1 -0.9 0.8 0.8 -1.4 0.8 1.1
Arm predicted mass (right) 0.2 0.8 3.0 0.3 1.2 0.8 1.7 -0.3 0.1 0.7
Pulse rate, automated reading 0.6 2.0 3.8 -1.4 1.5 -1.8 0.6 1.9 -1.3 -0.7
Alcohol intake frequency. 1.0 2.4 6.2 -0.6 -0.6 -2.5 -1.8 -0.9 -2.0 -1.2
Comparative height size at age 10 0.6 3.2 9.2 0.3 3.0 0.5 2.7 1.0 1.9 1.0
Number of full sisters 0.7 0.9 3.3 -0.1 -1.4 0.7 -0.1 -1.8 -0.2 -0.8
Suffer from ‘nerves’ 1.5 2.4 8.6 0.6 -0.9 -2.5 -0.3 -2.9 -0.2 -0.8
Overall health rating 1.4 3.0 7.8 -1.6 -1.7 -2.8 -0.6 -1.4 -1.9 -1.4
Chest pain or discomfort 0.4 0.6 1.6 0.2 -0.8 -1.3 -0.4 -1.1 -0.8 -0.1
Had major operations 0.2 0.2 0.7 -0.5 -0.1 -0.8 -0.4 -0.3 0.1 0.4
Age at last live birth 2.1 3.1 10.0 1.2 2.2 3.2 0.7 0.3 1.4 1.6
Family relationship satisfaction 0.2 0.3 1.1 -0.1 0.3 -0.4 1.0 -0.7 0.0 0.2
Leg pain on walking 0.3 0.4 1.7 0.4 -0.2 0.4 0.4 1.3 0.0 -0.8
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.4 4.0 -0.4 -1.1 -1.5 -0.2 -0.3 -2.0 -1.4
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.3 -1.1 0.7 0.7 0.7 0.5 0.7 0.5
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.9 0.9 0.3 -0.5 -0.6 -0.4 -0.1 -0.1
Medication: Aspirin 1.3 1.8 6.6 -0.6 -2.6 -1.5 0.0 -1.1 -0.4 -1.3
Supplements: Vitamin C 0.8 0.9 3.5 1.9 0.9 0.7 0.1 0.9 0.7 0.5
Knee pain experienced in last month 0.4 0.6 2.2 -0.4 -0.7 0.1 0.4 -1.5 -1.1 -0.4
Hypertension (Self-reported) 0.9 2.6 5.2 -2.3 -2.0 -1.4 -0.0 -1.2 -1.9 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 5.8 0.5 -0.8 -0.7 -2.4 -0.8 -0.8 -1.1
Illnesses of father: Heart disease 0.6 0.9 2.7 1.3 1.0 0.3 -0.3 0.3 1.6 0.7
Illnesses of siblings: Diabetes 0.9 1.2 4.0 0.9 0.4 0.3 0.7 -1.0 2.0 1.2
Smoking status: Previous 0.8 1.2 3.4 1.8 0.5 0.9 -0.1 1.0 1.3 1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 3.9 -0.5 1.4 -0.6 2.0 -0.4 -0.1 0.6
Whole body fat-free mass 0.2 1.2 5.0 0.1 0.8 0.7 2.2 -0.8 0.5 1.0
Leg fat-free mass (right) 0.3 1.5 6.2 0.1 -0.3 0.7 2.5 -1.4 0.8 1.0
Arm fat percentage (left) 0.5 1.9 4.8 -0.3 -2.2 0.6 1.2 -2.0 1.0 1.1
Average weekly red wine intake 0.9 1.3 2.8 -0.1 1.2 1.7 0.8 1.3 1.5 0.5
Handedness (chirality/laterality): Left-handed 2.6 3.2 7.5 -2.7 0.3 -2.3 0.6 1.7 -2.1 -1.2
Mood swings 0.9 1.7 3.8 2.0 -0.6 1.7 -1.8 -1.2 -0.0 0.3
Loneliness, isolation 1.0 1.4 4.9 0.7 -0.7 -0.8 -1.1 -2.2 -1.2 -0.6
Long-standing illness, disability or infirmity 1.0 1.5 3.7 -1.7 -0.9 -1.9 0.3 -0.2 -1.0 -1.3
Ever had bowel cancer screening 1.0 1.2 3.7 0.4 -0.1 -1.0 -1.9 -1.8 -0.5 -0.1
Diabetes diagnosed by doctor 0.3 0.5 1.4 -1.2 0.8 -1.0 0.5 0.1 -0.2 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 1.9 -1.4 0.7 -0.8 0.5 1.3 -0.7 -0.4
Friendships satisfaction 0.4 0.5 1.7 -0.1 -0.2 -0.9 1.3 -0.2 0.9 -0.2
Qualifications: nursing, teaching 0.4 0.7 1.9 -0.8 0.8 0.4 1.4 -0.3 1.0 0.4
Commuting to job workplace: Walk 0.1 0.1 0.3 0.2 -0.2 0.5 -0.4 0.3 0.3 -0.4
Eye problems/disorders: Cataract 0.5 0.5 1.6 -1.3 0.5 0.1 1.1 0.7 -0.2 0.1
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.6 0.2 1.6 1.0 0.9 1.4 0.7 0.2
Medication for cholesterol 0.2 0.2 0.6 0.2 0.8 0.4 0.2 -0.1 0.8 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.0 2.4 7.2 0.3 -0.3 1.1 2.7 -1.1 2.1 1.6
Back pain experienced in last month 1.5 2.1 6.7 -2.6 -0.0 -1.2 2.1 0.2 -1.4 -0.8
Mineral and other dietary supplements 1.3 1.8 4.5 -1.4 -0.2 -1.8 -0.6 -0.1 -2.1 -1.5
Breast cancer (self-reported) 0.7 0.8 4.0 0.9 -0.4 0.4 -2.0 -0.1 -0.5 -0.4
Asthma (self-reported) 0.3 0.6 2.1 -0.7 1.0 -0.3 0.6 1.4 -0.5 -0.1
Osteoporosis (self-reported) 0.9 1.2 3.1 0.2 -0.4 1.5 -1.8 -0.9 1.2 0.6
Osteoarthritis (self-reported) 1.2 1.6 5.2 0.0 -1.7 -0.8 -1.1 -2.3 -0.9 -0.3
Medication: Aspirin 1.4 1.8 6.2 -1.0 -2.5 -1.6 0.6 -1.1 -0.3 -1.3
Medication: Gliclazide 0.3 0.3 1.5 -0.0 0.8 -1.2 0.2 0.3 0.3 0.0
Illnesses of father: None of the above (group 1) 0.2 0.2 0.8 -0.2 0.1 -0.1 0.9 0.2 0.5 0.6
Smoking status: Current 0.7 1.1 3.2 0.4 -1.5 0.7 -1.8 -1.3 -0.3 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 2.0 5.6 -0.2 -2.4 -0.7 -0.8 -2.3 -0.4 -1.2
Whole body water mass 0.2 1.1 5.1 0.0 0.8 0.6 2.3 -0.9 0.3 0.9
Leg predicted mass (right) 0.3 1.5 6.7 0.1 -0.2 0.7 2.6 -1.3 0.8 1.0
Arm fat mass (left) 0.4 1.7 4.0 -0.1 -1.7 0.6 1.6 -2.0 0.8 1.0
Number of self-reported non-cancer illnesses 0.8 1.4 3.5 -0.5 -1.7 -1.9 -0.6 -1.3 -0.9 -0.3
Average weekly champagne plus white wine intake 0.5 0.7 1.9 -0.3 0.5 1.1 0.7 -0.4 0.8 1.4
Miserableness 0.8 1.4 3.1 1.1 -1.5 0.7 1.6 -1.7 0.0 0.4
Guilty feelings 1.8 2.8 6.0 1.4 0.8 2.3 2.5 -0.6 1.9 1.2
Wears glasses or contact lenses 0.4 0.5 1.4 -0.3 -1.2 0.9 0.3 -0.7 -0.5 -0.5
Ever taken oral contraceptive pill 0.9 1.0 4.4 0.4 -0.8 0.4 -2.1 -1.0 -0.7 -0.1
Hearing aid user 0.7 0.8 1.5 -0.8 0.9 -1.0 0.2 0.8 -1.0 -1.2
Mother’s age at death 0.9 1.1 4.0 0.3 -0.7 0.2 -1.2 0.2 -1.4 -2.0
Financial situation satisfaction 0.7 0.8 1.9 1.1 0.9 0.1 1.4 -0.1 1.1 0.8
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.9 0.1 -0.1 -0.9 0.1 0.3 0.8 -1.4
Commuting to job workplace: Public transport 0.3 0.4 1.2 0.6 1.1 0.1 -0.4 0.0 0.9 0.7
Eye problems/disorders: Glaucoma 1.5 1.8 6.4 -1.3 0.5 -1.6 0.8 0.9 -2.5 -0.6
Medication: Blood pressure 0.5 1.0 2.6 -1.6 -0.8 -1.1 1.1 0.1 -1.1 -0.6
Pain type(s) experienced in last month: Hip pain 1.1 1.4 3.5 0.8 1.0 0.4 1.9 0.3 1.1 1.9
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.6 -0.1 -0.3 1.3 0.9 0.8 0.7 -0.0
High cholesterol (Self-reported) 2.5 4.3 15.4 1.2 -2.6 0.6 -2.1 -3.9 1.5 0.3
Medication: Bendroflumethiazide 0.8 1.2 3.3 -1.2 -1.8 -0.7 0.5 -0.6 -0.9 -1.3
Medication: Paracetamol 0.9 1.3 4.2 0.2 0.4 -0.1 1.3 -0.1 1.8 2.0
Medication: Lisinopril 1.7 2.2 8.0 -2.4 -0.8 0.4 2.8 -0.0 -0.5 -0.5
Medication: Atorvastatin 1.0 1.2 3.8 1.3 -0.6 0.1 -1.5 -1.9 0.5 -0.0
Illnesses of father: High blood pressure 1.3 1.6 3.5 0.2 -1.3 -0.1 -1.2 -1.7 -1.9 -1.2
Alcohol drinker status: Never 0.6 0.8 2.0 -0.1 1.1 0.7 -0.2 0.9 -1.4 -0.9
Ever smoked 0.9 1.6 5.0 2.0 -1.0 2.2 -0.8 0.0 0.9 0.4
Basal metabolic rate 0.2 1.3 5.7 0.1 0.6 0.7 2.4 -1.0 0.6 1.1
Leg fat percentage (left) 0.1 0.3 0.9 -0.3 -0.6 0.4 0.3 -0.5 0.5 0.9
Arm fat-free mass (left) 0.2 1.2 4.2 0.3 1.4 0.8 2.1 -0.3 0.6 1.1
Number of operations (self-reported) 0.2 0.2 1.2 -0.1 -0.3 -0.5 1.1 -0.1 0.2 0.2
Average weekly beer plus cider intake 1.1 1.6 3.9 0.9 2.0 0.8 -1.6 1.8 -0.2 -0.4
Irritability 1.1 1.9 5.7 0.4 -1.0 -0.4 -2.4 -1.2 -1.8 -1.3
Risk taking 0.9 1.3 3.0 1.2 0.4 1.2 -1.6 -1.7 0.7 0.3
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.4 -0.8 0.7 -0.9 1.2 -0.4 -0.5 -0.7
Fractured/broken bones in last 5 years 0.4 0.6 2.0 -0.3 0.9 -0.1 -0.7 1.4 0.5 0.5
Age started oral contraceptive pill 1.2 1.5 3.5 -1.5 -0.9 -1.3 0.3 1.9 -1.3 -0.8
Diastolic blood pressure, automated reading 0.5 1.4 4.0 -0.8 -1.0 0.7 -0.6 -1.1 -1.6 -2.0
Ever depressed for a whole week 0.5 0.6 3.1 0.2 0.8 1.8 0.4 -0.6 -0.4 0.0
Unable to work because of sickness or disability 0.6 0.8 2.4 0.4 1.6 0.7 0.6 0.7 1.2 0.3
Commuting to job workplace: Cycle 1.4 1.7 5.7 0.1 -2.3 -0.8 -0.2 -2.4 -0.1 0.5
Myopia 2.3 3.3 6.3 -1.6 -2.3 -1.3 -2.3 0.3 -1.4 -2.5
Vascular/heart problems diagnosed by doctor 0.8 2.2 4.8 2.1 2.2 1.0 -0.1 1.5 1.4 1.1
Cholesterol lowering medication 1.2 1.7 4.8 0.6 -2.2 0.7 -1.6 -1.6 -0.5 -1.0
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 3.1 -0.0 0.4 -1.8 -1.5 0.0 -1.1 -0.8
Pain experienced in last month 0.5 0.8 2.2 1.5 0.8 1.2 0.1 0.9 0.5 0.1
Supplements: Calcium 1.0 1.1 3.8 0.3 1.1 0.4 -0.6 1.9 1.4 -0.0
Basal cell carcinoma (self-reported) 2.6 3.1 7.5 2.3 -0.8 2.3 -2.7 -1.4 0.7 0.6
Heart attack/myocardial infarction (self-reported) 0.7 0.9 2.0 0.1 -1.4 1.1 0.2 -1.0 1.3 0.7
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.8 0.1 -0.9 -0.0 0.5 -0.1 -0.1 0.1
Heart disease (siblings) 1.6 2.0 10.0 0.0 -1.2 0.4 -3.2 -1.3 -0.8 -0.4
Alcohol drinker status: Previous 0.3 0.4 0.8 -0.6 0.1 -0.5 -0.9 -0.5 -0.4 -0.9
Pack years of smoking 0.4 0.6 1.4 -1.2 -0.6 -0.4 -0.5 -0.6 -1.1 -0.9
Impedance of whole body 0.2 0.9 2.6 -0.4 1.6 0.9 -0.0 1.6 -0.2 0.4
Leg fat mass (left) 0.2 0.8 1.6 -0.2 -0.7 0.9 1.2 -1.1 0.7 1.1
Arm predicted mass (left) 0.2 1.1 4.3 0.4 1.1 0.7 2.1 -0.6 0.5 1.1