Hub : Genes

ACOX2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.5197	0.0973	1.8e-05	0.015	NA	0.086	NA	0.013	0.09400	NA	0.00054	NA	0.1000
2	GTEx	Heart Atrial Appendage	0.1280	0.0550	2.9e-03	0.003	NA	0.016	NA	-0.005	0.22000	NA	0.05900	NA	0.6900
3	GTEx	Muscle Skeletal	0.1103	0.0482	4.8e-03	0.003	NA	0.004	NA	0.000	0.14000	NA	0.11000	NA	0.3400
4	METSIM	Adipose	0.0624	0.0240	4.5e-04	0.021	0.022	0.010	0.024	0.013	0.00038	0.00024	0.01100	0.00013	0.0044
5	TCGA	Colon Adenocarcinoma	0.1700	0.0620	3.7e-04	0.003	0.039	0.054	NA	0.013	0.22000	0.00260	0.00047	NA	0.0580
6	TCGA	Brain Lower Grade Glioma	0.0423	0.0205	7.9e-03	-0.002	0.020	-0.002	NA	-0.002	0.88000	0.00240	0.56000	NA	0.9100
7	TCGA	Thyroid Carcinoma	0.0620	0.0300	2.2e-03	-0.003	0.014	0.021	NA	-0.002	0.81000	0.01600	0.00330	NA	0.6300

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.5	0.8	2.5	0.9	0.3	-0.5	-0.4	-1.1	1.6	0.9
Bipolar Disorder or Schizophrenia	0.5	1.1	3.0	0.0	1.1	-0.7	-0.1	-0.6	1.7	1.7
Depressed Affect (Nagel 2018)	0.6	1.3	2.2	0.9	-0.8	1.0	-1.5	-1.5	-1.4	-0.6
Depression (Nagel 2018)	0.3	0.4	1.2	0.1	1.1	-0.5	0.5	0.7	-0.7	-0.6
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.2	1.1	1.0	-0.3	0.6	0.5	-0.5	0.3
Neuroticism (Nagel 2018)	0.5	1.1	2.8	0.6	-0.9	-0.2	-1.7	-1.4	-1.2	-0.5
Schizophrenia (2018)	0.3	0.7	1.8	-0.9	1.1	-0.5	0.4	-0.1	0.8	1.4
Schizophrenia vs Biploar Disorder	1.1	1.4	3.2	-1.8	0.6	-0.5	-1.2	0.8	-1.7	-1.1
Worry (Nagel 2018)	1.1	2.4	10.3	0.3	-1.1	-1.2	-3.2	-1.8	-0.7	-0.3
Alzheimer’s Disease (in mother)	0.9	1.0	2.5	-0.9	-0.3	0.3	1.0	0.7	1.5	1.6
Alzheimer’s Disease (in father)	0.7	0.8	2.0	0.1	0.8	0.2	0.9	0.7	1.4	1.2
Alzheimer’s Disease (including proxy)	1.6	2.4	6.4	-0.5	0.8	0.5	1.6	0.8	2.4	2.5
Crohns Disease (2017)	0.3	0.7	1.5	0.6	0.6	0.5	1.2	-0.2	1.0	1.1
Irritable Bowel Disease (IBD)	0.3	0.8	2.8	0.6	1.2	0.5	-0.1	0.2	1.0	1.7
Ulcerative Colitis (UC)	0.6	1.1	3.2	0.2	1.6	0.3	-0.9	0.7	0.7	1.8
Major Depression (MDD)	0.5	0.6	2.0	-0.4	0.3	-1.4	-0.5	0.9	-0.6	-0.6
Reaction Time	0.6	1.2	3.6	-1.9	-0.7	-0.7	1.2	-0.4	-1.0	-1.1
Verbal and Numeric Reasoning (VNR)	1.1	2.7	9.9	0.3	3.1	0.2	2.1	1.7	0.3	1.2
Breast Cancer	0.1	0.2	0.6	-0.1	0.2	0.8	0.4	0.4	0.1	-0.2
Ovarian Cancer	0.8	1.1	3.0	-1.3	-0.5	-0.6	1.0	-0.5	-1.0	-1.7
Prostate Cancer	0.2	0.3	1.1	0.7	-1.0	-0.3	0.2	-0.3	-0.2	-0.5
Age at First Birth	0.6	0.9	1.9	0.5	1.4	0.6	1.3	0.7	0.7	1.1
Bipolar Disorder (2011)	0.4	0.4	1.2	1.1	-0.2	0.7	-1.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.3	2.2	-1.4	-1.5	-0.1	-0.8	-0.9	-1.5	-1.0
Coronary Artery Disease (CAD)	0.5	0.6	1.6	-1.3	-0.9	0.1	-0.4	0.2	-1.0	-0.6
Crohns Disease (2012)	0.8	1.2	5.0	-0.2	-1.1	-0.6	-0.4	-2.2	-0.2	-1.3
Mean Putamen Volume	1.2	1.4	6.1	-0.5	-0.2	-2.5	0.8	-0.9	-1.3	0.1
Fasting Glucose	0.9	1.1	3.8	-0.2	1.3	-0.8	0.8	-1.9	1.0	-0.3
HbA1C	2.1	2.3	7.5	-2.3	-0.7	-1.3	2.7	0.3	-0.2	-1.2
HDL Cholesterol	0.3	0.5	1.2	0.1	-0.6	1.1	0.2	-0.6	0.6	1.1
LDL Cholesterol	1.0	1.6	4.2	-0.0	-0.4	1.0	0.0	-2.1	1.7	1.7
Lupus	3.0	4.6	19.2	-0.7	4.4	-1.4	0.9	2.8	0.4	1.2
Neuroticism (2016)	0.5	0.8	3.1	-0.4	-0.0	-1.8	0.1	0.1	-1.1	-1.1
Primary Biliary Cirrhosis	1.0	1.4	4.6	0.4	2.1	0.4	1.4	0.3	1.3	1.1
Rheumatoid Arthritis	0.9	1.2	2.9	-0.9	-1.5	-0.4	-0.5	-1.7	-0.8	-1.2
Schizophrenia (2014)	0.3	0.7	2.3	-0.5	1.5	-0.2	-0.2	-0.7	0.7	1.1
Triglycerides	0.4	0.6	2.7	-0.3	-0.2	-1.0	0.3	-1.6	-0.4	-0.7
Type 2 Diabetes (T2D) (2012)	2.0	2.3	4.6	0.6	1.7	1.4	1.1	1.1	2.1	2.1
Ulcerative Colitis	0.6	0.8	2.9	0.4	1.0	-0.4	-1.7	-0.5	0.6	0.9
Blood Eosinophil Count	0.3	2.6	7.1	1.0	2.7	0.7	0.5	1.4	2.2	1.7
Blood Platelet Count	2.9	33.3	102.0	-0.7	-10.1	1.5	-8.3	-6.4	-3.9	-1.6
Blood Red Count	1.1	10.7	53.1	1.4	7.3	-2.2	0.9	2.5	1.3	2.5
Blood White Count	0.1	0.8	3.0	-1.4	-0.2	0.6	1.7	0.2	0.3	0.6
Heel T-Score	0.8	6.4	13.9	-2.2	-1.9	-3.5	-1.3	-0.4	-3.7	-2.9
BMI	0.4	2.2	9.0	-0.8	-3.0	-0.2	0.9	-2.1	0.2	0.8
Height	0.9	16.5	44.6	0.5	6.2	2.8	6.7	2.6	2.6	3.2
Waist Hip Ratio (WHR)	0.4	1.7	8.0	-0.5	2.8	0.8	0.5	0.4	0.5	1.6
Systolic Blood Pressure	0.6	3.1	9.2	-3.0	-2.6	0.6	0.9	-1.4	-1.1	-1.2
Smoking Status	0.5	1.3	2.9	1.7	-0.3	1.3	-1.6	-0.2	0.8	1.0
Allergy or Eczema	0.2	0.6	1.0	0.9	0.5	1.0	-0.9	-1.0	-0.3	0.5
Cardiovascular Disease	0.5	1.6	5.3	-0.4	-2.1	0.4	-0.4	-2.3	0.4	0.9
Hypothyroidism (self reported)	0.8	1.7	5.7	1.9	2.4	-0.3	-0.1	0.6	0.9	1.3
Respiratory disease	0.3	0.7	3.0	-0.4	0.5	-0.9	0.2	1.7	-0.6	0.1
Type 2 Diabetes (T2D) (2018)	0.6	1.0	3.0	0.9	1.7	-0.2	0.4	-0.2	1.6	0.8
Lung FEV1/FVC ratio	0.3	1.7	4.2	0.2	-2.1	-0.9	-1.0	-1.9	-0.3	-1.5
Lung FVC	1.1	5.8	12.4	-0.2	-3.5	-1.1	-2.3	-1.6	-2.8	-3.4
Neuroticism	0.7	1.7	6.4	1.1	-1.1	0.1	-1.7	-2.5	-0.7	-0.3
Chronotype (morning person)	0.3	0.6	1.2	0.1	0.8	-1.1	0.7	0.9	-0.3	-0.9
Hair Pigment	0.0	1.0	2.6	1.0	0.9	0.5	-1.6	1.1	0.7	0.7
Tanning	0.1	0.9	3.4	-0.1	-0.9	-0.2	0.9	0.0	-1.8	-1.2
Hand grip strength (left)	0.2	0.6	1.6	-0.3	0.4	-0.1	1.0	0.5	-1.3	-1.0
Number of treatments/medications taken	0.3	0.6	2.9	-0.1	-1.7	0.4	0.1	-0.8	0.3	-0.3
Average weekly spirits intake	1.9	2.3	6.3	1.6	0.1	2.5	-1.3	-0.4	2.0	1.3
Sensitivity / hurt feelings	0.5	0.9	3.6	1.4	-0.4	1.9	0.1	-0.6	0.1	0.5
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.3	1.0	0.6	0.4	1.1	-0.5	0.6	0.2
Hearing difficulty/problems: Yes	0.2	0.2	0.7	0.3	-0.6	-0.3	-0.6	0.2	-0.2	-0.9
Relative age of first facial hair	0.2	0.4	2.4	-0.4	-1.5	0.5	0.2	-0.0	-0.1	-0.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.4	1.0	0.5	0.4	0.1	0.5	1.2	0.8
Ever used hormone-replacement therapy (HRT)	3.2	4.1	12.8	1.6	-3.6	-0.8	-1.9	-2.3	-1.3	-1.2
Ever had hysterectomy (womb removed)	1.1	1.3	3.6	1.2	-1.5	0.6	-1.9	-1.0	0.3	-0.4
Systolic blood pressure, automated reading	0.9	2.5	7.7	-2.6	-2.8	-0.3	0.7	-0.6	-0.7	-1.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.5	-1.0	-1.2	-0.2	0.3	-1.6	0.3	-0.2
Angina	1.0	1.3	3.5	-0.8	-1.9	-1.2	-0.4	-0.7	-1.0	-1.4
Medication for hormone replacement therapy	0.1	0.1	0.2	0.5	0.2	0.3	0.2	-0.2	-0.1	-0.3
Vitamin and mineral supplements	0.7	1.0	3.0	-0.9	-0.7	-0.8	-0.5	-0.3	-1.7	-1.2
Supplements: Zinc	0.5	0.5	1.1	-0.2	0.6	-0.9	-1.1	0.9	0.4	-0.4
Medication: Co-codamol	2.1	2.4	5.6	-1.0	-2.1	-1.2	-0.4	-2.4	-1.0	-1.9
Medication: Metformin	0.5	0.7	1.9	-0.2	1.3	-0.9	1.4	0.4	-0.3	-0.2
Diabetes (father)	0.1	0.1	0.2	0.0	-0.0	0.5	-0.1	-0.4	0.2	-0.3
Diabetes (mother)	1.0	1.2	5.5	0.4	0.1	-0.6	-1.5	-2.3	-0.3	-0.4
Severe depression (siblings)	1.4	1.5	6.4	-0.3	1.2	-0.8	2.5	-1.2	0.3	0.7
Pack years adult smoking proportion	0.4	0.6	1.2	-1.0	-0.5	-0.2	-0.4	-1.0	-1.1	-0.8
Impedance of leg (right)	0.4	1.7	5.5	0.3	2.3	0.9	-1.4	1.9	-0.3	0.3
Leg fat-free mass (left)	0.3	1.5	5.4	0.1	-0.2	0.8	2.3	-1.5	0.9	1.1
Trunk fat percentage	0.3	1.1	2.7	-0.2	-1.2	0.8	1.6	-0.9	0.8	1.1
Hand grip strength (right)	0.2	0.6	1.9	-0.3	0.5	1.4	0.6	0.1	-1.1	-0.5
Townsend deprivation index at recruitment	1.0	1.4	3.7	-1.0	-0.7	-1.9	-0.5	-1.2	-1.4	-1.0
Current tobacco smoking	0.8	1.2	3.5	0.4	-1.5	0.5	-1.9	-1.6	-0.5	-0.2
Average weekly fortified wine intake	0.5	0.6	2.3	-0.2	1.5	-0.2	1.1	0.2	0.2	0.6
Maternal smoking around birth	0.5	0.7	1.5	0.1	0.9	-0.0	-1.2	1.1	-0.3	-1.0
Fed-up feelings	0.7	1.3	3.2	-1.1	0.3	-0.4	-1.1	1.0	-1.8	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.2	-1.2	1.4	-1.3	2.1	1.4	0.0	-0.1
Relative age voice broke	0.4	0.7	1.3	-0.0	-0.9	1.1	-0.8	-0.7	1.1	0.7
Taking other prescription medications	0.4	0.6	2.3	-0.7	-0.9	-1.5	0.2	-0.2	-0.7	-0.2
Age when periods started (menarche)	1.0	2.5	9.9	-0.4	3.1	-1.7	0.1	1.9	-0.4	0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.8	0.9	-0.0	-0.5	-0.2	-0.0	-0.5	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	4.0	-1.8	0.2	-2.0	0.8	-0.2	-1.4	-1.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	3.4	0.5	1.8	0.6	0.0	1.4	-0.3	0.6
Qualifications: CSEs or equivalent	0.2	0.3	0.8	0.9	-0.9	-0.4	-0.3	-0.6	0.0	0.1
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.5	-0.3	-0.1	-0.4	0.2	-0.3	-0.2
High blood pressure	0.7	1.8	4.5	-2.1	-1.5	-1.3	0.2	-1.1	-1.5	-1.0
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.2	0.5	0.8	1.1	0.3	-0.6	-0.2	0.5
Multivitamins +/- minerals	0.9	1.1	2.8	-0.9	1.2	-0.0	1.3	0.0	1.7	1.2
Stomach or abdominal pain in last month	0.7	0.8	4.8	0.6	-0.3	-0.7	-2.2	-0.0	0.0	0.5
Supplements: Glucosamine	0.9	1.1	2.7	1.6	0.5	1.6	0.4	0.9	1.1	0.6
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	5.9	-0.4	-1.1	-2.4	-0.7	-1.6	-0.1	0.3
Medication: Atenolol	0.3	0.4	0.8	-0.5	-0.9	-0.7	0.3	-0.4	-0.2	-0.9
Medication: Levothyroxine sodium	0.8	1.3	3.0	1.0	1.6	-1.4	0.7	1.7	0.2	0.4
Sitting height	1.1	8.0	19.6	1.8	4.2	2.7	4.4	2.7	0.5	1.0
Chronic bronchitis/emphysema (father)	1.8	2.1	4.6	-1.7	-0.5	-2.1	-1.2	1.0	-1.6	-1.5
High blood pressure (mother)	2.0	2.9	8.5	-0.0	-2.1	0.1	-2.1	-2.9	-1.4	-0.7
Body mass index (BMI)	0.3	1.3	4.3	0.0	-2.1	0.1	0.7	-1.8	0.6	0.6
Impedance of leg (left)	0.4	2.0	6.4	-0.1	2.5	0.7	-0.9	2.4	-0.6	-0.0
Leg predicted mass (left)	0.3	1.4	5.1	0.2	-0.2	0.7	2.2	-1.5	0.8	1.0
Trunk fat mass	0.3	1.3	4.1	-0.3	-0.7	1.0	2.0	-1.0	1.0	1.3
Waist circumference	0.4	1.4	2.7	-0.1	0.0	1.0	1.3	-1.5	1.3	1.6
Number of incorrect matches in round	0.2	0.4	1.1	-0.3	-0.9	-1.0	-0.1	-0.4	-0.5	-0.4
Past tobacco smoking	0.9	1.7	5.7	-2.4	0.6	-1.6	1.1	-0.2	-1.1	-0.7
Alcohol usually taken with meals	1.8	2.9	8.8	-0.2	1.2	1.4	3.0	1.3	1.9	1.7
Nervous feelings	0.7	1.3	3.8	2.0	-0.1	-0.6	-1.7	-1.5	0.3	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.5	-0.6	-0.1	0.0	0.4	-1.2	0.3	0.2
Hearing difficulty/problems with background noise	0.4	0.7	2.7	0.1	-0.1	1.6	1.3	0.4	0.3	0.0
Hair/balding pattern: Pattern 2	0.3	0.3	0.8	-0.4	-0.8	0.1	-0.5	-0.6	0.4	0.9
Had menopause	0.8	1.0	2.9	1.0	-1.3	-0.4	-1.7	-0.1	-0.7	-0.8
Had other major operations	0.9	1.2	4.0	-0.1	-0.6	-0.8	-0.4	0.6	-1.6	-2.0
Forced vital capacity (FVC)	0.2	0.9	3.0	-0.5	-0.4	0.6	0.8	-0.6	-1.7	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.0	-1.0	0.6	-0.9	-0.2	-0.8	-0.3	-0.5
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.8	-0.7	-0.6	-0.3	-1.1	-0.1	-1.9	-1.3
Qualifications: None of the above	0.9	1.9	3.7	-0.6	-1.9	-0.6	-1.9	-1.0	-1.5	-1.5
Financial difficulties in last 2 years	0.3	0.4	1.3	-0.0	0.1	1.1	0.1	-0.8	0.6	0.5
Mouth/teeth dental problems	0.9	1.4	4.9	-2.2	0.7	-1.4	1.0	0.8	0.5	0.6
Heart attack	0.6	0.8	2.6	0.0	-1.6	1.1	-0.0	-1.0	0.9	0.3
Allergy	0.1	0.2	0.8	-0.2	0.1	-0.8	-0.2	0.3	0.9	0.2
Pain all over the body in last month	1.7	1.9	3.4	-1.5	-1.6	-1.3	-0.8	-1.8	-1.2	-1.1
Diabetes (self-reported)	0.6	0.9	2.6	-1.6	1.0	-1.1	0.9	0.5	0.1	-0.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.2	1.0	0.2	0.5	0.6	-1.1	0.8	0.8
Medication: Ramipril	2.6	3.3	7.4	-1.2	-2.3	-1.9	-0.3	-1.6	-1.6	-2.7
Medication: Simvastatin	1.0	1.5	4.7	-0.3	-2.2	0.9	-1.0	-2.0	-0.3	-0.4
Fluid intelligence score	0.7	1.5	4.7	-0.0	2.2	0.7	1.5	0.8	0.5	1.4
Illnesses of siblings	0.5	0.7	2.5	-0.0	1.1	-0.3	0.9	1.6	0.1	-0.1
Neuroticism score	0.6	1.2	4.2	1.6	-0.6	0.4	-1.2	-2.0	-0.4	-0.0
Weight	0.3	1.7	5.7	-0.1	-0.1	1.0	2.4	-1.3	1.1	1.4
Impedance of arm (right)	0.1	0.5	1.2	-0.5	0.7	0.7	0.6	1.1	0.5	0.6
Arm fat percentage (right)	0.5	1.9	4.3	-0.3	-2.1	0.6	1.3	-2.1	1.1	1.3
Trunk fat-free mass	0.2	1.3	5.1	0.0	1.5	0.6	2.2	-0.6	0.4	1.0
Hip circumference	0.4	1.7	3.3	0.5	-0.0	0.8	1.8	-1.3	1.6	1.8
Time employed in main current job	0.6	0.6	2.3	-1.2	-1.5	-0.7	0.1	-0.4	-0.3	-0.3
Alcohol intake versus 10 years previously	0.8	1.2	2.7	1.3	1.6	0.3	-1.2	0.7	0.3	1.5
Father’s age at death	0.9	1.2	6.5	-0.9	-0.5	0.3	2.6	0.8	0.2	0.4
Worrier / anxious feelings	0.3	0.6	1.8	0.5	-0.2	-0.0	-1.4	-1.3	-0.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	-0.3	-0.4	-0.7	0.2	-0.6	-0.5	0.0
Falls in the last year	0.6	0.9	3.6	-0.9	-0.2	1.0	1.9	-0.7	0.1	0.2
Hair/balding pattern: Pattern 3	0.9	1.4	3.5	-1.0	1.4	-0.6	0.4	1.9	-1.5	-0.4
Number of live births	0.4	0.6	2.1	-0.1	-1.5	1.2	-0.4	-0.2	-0.3	0.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.3	-0.6	-1.5	-0.0	0.6	-1.4	-1.4	-1.5
Pulse rate	1.4	2.3	3.5	-1.3	1.2	-1.9	1.7	1.9	-1.5	-1.1
Happiness	0.2	0.3	0.7	0.8	0.8	0.3	-0.5	-0.1	0.3	0.3
Noisy workplace	1.4	1.8	4.9	-0.1	-2.2	-0.6	-1.5	-0.1	-1.0	-2.0
Qualifications: A levels/AS levels or equivalent	1.9	4.1	9.1	1.2	2.1	2.4	1.3	0.9	2.3	3.0
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.7	0.1	0.1	-0.1	0.5	-0.4	-0.0	0.9
Mouth/teeth dental problems: Dentures	0.6	1.0	2.3	1.5	-0.7	0.4	-1.0	-1.2	-0.7	-1.2
Asthma	0.2	0.5	1.7	-0.7	0.8	-0.3	0.3	1.3	-0.5	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.0	0.9	-0.9	1.0	-0.6	-0.9	-0.1	-0.7
Medication: Cholesterol lowering	1.0	1.5	4.7	-0.2	-1.8	0.6	-1.2	-2.2	0.8	-0.1
Depression (self-reported)	1.0	1.2	4.1	0.7	2.0	0.6	0.5	1.3	-1.1	-0.8
Medication: Lansoprazole	0.5	0.6	2.7	1.6	0.4	0.7	-0.2	-0.3	0.8	0.5
Prospective memory result	0.6	0.8	2.1	0.1	-0.4	1.0	-1.5	0.8	-0.3	-1.2
Lung cancer (father)	0.3	0.4	1.4	-0.3	-0.2	1.2	0.8	0.5	0.3	-0.2
Illnesses of mother	1.1	1.4	2.7	1.2	1.6	0.3	1.0	1.5	1.0	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.8	3.8	-0.9	-1.3	-0.9	0.3	-1.2	-1.9	-1.9
Pulse wave Arterial Stiffness index	1.3	1.5	2.8	-0.7	1.1	-1.4	0.7	1.2	-1.5	-1.7
Impedance of arm (left)	0.1	0.3	0.8	-0.4	0.5	0.7	0.5	0.9	0.1	0.2
Arm fat mass (right)	0.4	1.7	3.8	-0.4	-1.6	0.6	1.9	-1.8	0.8	1.0
Trunk predicted mass	0.3	1.5	5.6	0.1	1.7	0.8	2.4	-0.5	0.5	1.1
Standing height	0.6	6.2	17.2	-0.3	4.1	2.0	4.2	1.1	1.0	1.9
Length of working week for main job	0.6	0.6	1.7	0.3	-0.8	0.6	-1.2	-1.3	-0.4	0.4
Exposure to tobacco smoke at home	0.1	0.1	0.4	0.2	0.4	-0.4	0.6	-0.3	0.3	-0.3
Breastfed as a baby	0.9	1.2	3.3	0.4	1.2	0.5	1.1	1.8	0.2	1.3
Tense / ‘highly strung’	1.2	2.0	8.6	0.3	-0.9	-0.8	-2.9	-1.1	-0.8	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	4.2	0.2	0.8	-0.9	2.0	0.7	-0.1	-0.4
Hair/balding pattern: Pattern 4	0.3	0.7	2.6	0.3	-1.1	0.3	0.8	-1.6	0.6	-0.2
Birth weight of first child	1.4	2.5	5.6	0.7	1.4	2.4	2.4	-0.8	0.9	1.6
Peak expiratory flow (PEF)	0.1	0.3	0.8	-0.2	-0.8	-0.9	-0.0	-0.6	-0.6	-0.2
Pulse wave reflection index	0.2	0.2	0.6	0.2	0.1	-0.4	-0.6	0.1	-0.6	-0.8
Ever highly irritable/argumentative for 2 days	3.8	4.6	8.6	-2.9	-1.7	-2.5	1.3	-0.4	-2.6	-2.4
Loud music exposure frequency	0.2	0.2	0.8	0.9	0.2	0.5	-0.0	-0.5	0.2	0.1
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.2	-0.3	0.9	0.8	1.5	-0.3	1.8	1.6
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.3	0.8	-0.4	-0.3	-0.7	-0.4	-1.1	-0.7
Blood clot in the leg (DVT)	0.2	0.3	1.4	0.1	-1.2	0.3	0.5	-0.4	0.0	-0.0
Medication: Paracetamol	0.3	0.6	1.4	0.3	0.3	-0.9	1.0	0.2	0.7	1.2
Headache pain in last month	1.5	2.6	7.0	1.5	0.7	-0.4	0.3	-1.6	2.4	2.6
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	4.5	0.9	2.1	0.4	0.0	1.8	-0.2	0.2
Glaucoma (self-reported)	1.4	1.6	3.1	-1.4	0.9	-1.6	1.2	1.1	-1.8	0.2
Gout (self-reported)	0.3	0.4	1.2	-0.3	-1.1	-0.6	1.1	-0.4	-0.0	-0.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	3.4	0.5	1.8	-1.1	0.1	1.4	0.4	0.7
Medication: Amlodipine	0.2	0.3	1.4	-0.1	-0.4	-0.3	-1.2	0.5	-0.2	-0.3
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.8	-0.9	-1.0	-1.7	0.6	0.9	-1.1	-1.0
Birth weight	0.8	1.8	4.0	0.8	1.3	2.0	1.7	-0.6	1.2	1.3
Chronic bronchitis/emphysema (mother)	0.7	0.8	3.2	0.1	-0.1	0.4	-0.8	0.1	-1.8	-1.3
High blood pressure (siblings)	1.2	1.8	4.9	0.3	-1.5	2.0	-0.4	-2.2	0.0	1.0
Forced vital capacity (FVC), Best measure	0.4	1.3	4.1	-1.1	-0.8	-0.7	0.7	-0.9	-2.0	-1.4
Body fat percentage	0.2	1.0	1.7	-0.1	-1.1	0.8	1.3	-0.9	0.9	1.3
Leg fat percentage (right)	0.1	0.5	1.3	-0.1	-0.7	0.6	-0.1	-0.7	0.8	1.2
Arm fat-free mass (right)	0.1	0.8	2.9	0.0	1.2	0.5	1.7	-0.4	0.1	0.6
Exposure to tobacco smoke outside home	0.2	0.3	0.7	0.7	-0.1	0.1	-0.9	-0.7	0.2	-0.4
Comparative body size at age 10	1.1	2.9	11.4	0.0	-3.4	0.7	-0.8	-1.9	-1.7	-1.2
Number of full brothers	0.4	0.5	1.5	0.1	1.2	-0.3	-0.4	-0.0	-1.1	-0.3
Worry too long after embarrassment	0.3	0.6	3.3	0.0	0.2	-0.5	1.8	-0.2	0.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.1	1.4	1.2	-0.4	1.1	-0.3	1.3	0.1
Wheeze or whistling in the chest in last year	0.6	1.0	3.5	-1.0	0.2	-1.9	0.4	0.9	-0.9	0.9
Number of children fathered	0.2	0.2	0.8	0.5	-0.1	0.9	0.3	-0.4	0.1	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	1.4	0.7	-0.5	1.2	-1.0	0.0	1.1	0.4
Age at first live birth	1.7	3.0	5.7	0.7	2.2	2.3	2.4	0.2	1.4	1.6
Pulse wave peak to peak time	1.0	1.2	2.6	0.6	-0.8	1.4	-0.3	-1.0	1.3	1.6
Health satisfaction	0.7	0.9	4.7	0.1	-0.8	-0.4	2.2	-0.7	0.6	0.2
Shortness of breath walking on level ground	0.7	0.9	2.3	-1.5	0.4	0.0	1.4	1.0	-0.7	-0.7
Qualifications: College or University degree	1.5	4.8	11.4	1.2	1.1	3.4	1.6	-1.4	3.0	2.5
Eye problems/disorders: None of the above	1.3	1.5	2.9	1.2	-1.0	1.7	-0.9	-1.4	1.4	0.4
Mouth/teeth dental problems: Loose teeth	1.2	1.4	3.5	1.9	-1.3	0.8	-1.8	-0.9	0.4	-0.0
Emphysema/chronic bronchitis	1.1	1.3	5.3	-0.4	-0.2	-2.3	-0.2	0.8	-1.2	-1.1
Medication for pain relief, constipation, heartburn	0.8	1.4	5.4	0.6	2.3	0.8	-0.6	1.3	0.3	1.2
Neck or shoulder pain in last month	3.4	4.8	19.8	-2.6	-0.1	-4.4	0.8	0.4	-2.4	-0.9
Medication: Blood pressure	1.7	3.0	9.9	-1.4	-3.1	-1.2	0.1	-1.9	-0.9	-1.8
Angina (self-reported)	1.1	1.4	2.7	-1.0	-1.6	-1.5	-0.5	-0.5	-1.1	-1.4
Migraine (self-reported)	0.4	0.5	0.8	0.4	0.6	-0.9	0.6	0.8	-0.9	-0.4
Medication: Ibuprofen	0.3	0.3	1.2	0.6	-0.3	0.6	-0.3	-1.1	0.3	-0.1
Medication: Allopurinol	0.3	0.4	1.3	-0.3	-1.1	-0.6	0.4	-0.9	-0.1	-0.4
Medication: Omeprazole	0.7	0.9	2.6	-0.0	0.1	-1.0	-1.6	-0.4	-1.2	-1.0
Medication: Seretide 50 evohaler	1.9	2.2	4.8	-2.0	1.0	-0.5	2.2	1.7	-0.8	-1.1
Mean time to correctly identify matches	1.0	1.8	4.3	-2.1	-1.2	-1.3	1.3	-0.8	-1.1	-1.4
Heart disease (mother)	0.5	0.6	2.3	-1.5	0.2	-0.6	0.4	0.5	-0.4	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.1	0.3	-1.4	-0.8	-1.4	-1.1	0.0	-0.1
Whole body fat mass	0.3	1.2	2.3	-0.0	-1.0	0.9	1.5	-1.4	0.9	1.2
Leg fat mass (right)	0.2	0.8	1.8	-0.1	-0.9	0.8	0.8	-1.4	0.8	1.1
Arm predicted mass (right)	0.2	0.8	3.0	0.3	1.2	0.8	1.7	-0.3	0.1	0.7
Pulse rate, automated reading	0.6	2.0	3.8	-1.4	1.5	-1.8	0.6	1.9	-1.3	-0.7
Alcohol intake frequency.	1.0	2.4	6.2	-0.6	-0.6	-2.5	-1.8	-0.9	-2.0	-1.2
Comparative height size at age 10	0.6	3.2	9.2	0.3	3.0	0.5	2.7	1.0	1.9	1.0
Number of full sisters	0.7	0.9	3.3	-0.1	-1.4	0.7	-0.1	-1.8	-0.2	-0.8
Suffer from ‘nerves’	1.5	2.4	8.6	0.6	-0.9	-2.5	-0.3	-2.9	-0.2	-0.8
Overall health rating	1.4	3.0	7.8	-1.6	-1.7	-2.8	-0.6	-1.4	-1.9	-1.4
Chest pain or discomfort	0.4	0.6	1.6	0.2	-0.8	-1.3	-0.4	-1.1	-0.8	-0.1
Had major operations	0.2	0.2	0.7	-0.5	-0.1	-0.8	-0.4	-0.3	0.1	0.4
Age at last live birth	2.1	3.1	10.0	1.2	2.2	3.2	0.7	0.3	1.4	1.6
Family relationship satisfaction	0.2	0.3	1.1	-0.1	0.3	-0.4	1.0	-0.7	0.0	0.2
Leg pain on walking	0.3	0.4	1.7	0.4	-0.2	0.4	0.4	1.3	0.0	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	4.0	-0.4	-1.1	-1.5	-0.2	-0.3	-2.0	-1.4
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.3	-1.1	0.7	0.7	0.7	0.5	0.7	0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.9	0.9	0.3	-0.5	-0.6	-0.4	-0.1	-0.1
Medication: Aspirin	1.3	1.8	6.6	-0.6	-2.6	-1.5	0.0	-1.1	-0.4	-1.3
Supplements: Vitamin C	0.8	0.9	3.5	1.9	0.9	0.7	0.1	0.9	0.7	0.5
Knee pain experienced in last month	0.4	0.6	2.2	-0.4	-0.7	0.1	0.4	-1.5	-1.1	-0.4
Hypertension (Self-reported)	0.9	2.6	5.2	-2.3	-2.0	-1.4	-0.0	-1.2	-1.9	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	5.8	0.5	-0.8	-0.7	-2.4	-0.8	-0.8	-1.1
Illnesses of father: Heart disease	0.6	0.9	2.7	1.3	1.0	0.3	-0.3	0.3	1.6	0.7
Illnesses of siblings: Diabetes	0.9	1.2	4.0	0.9	0.4	0.3	0.7	-1.0	2.0	1.2
Smoking status: Previous	0.8	1.2	3.4	1.8	0.5	0.9	-0.1	1.0	1.3	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.9	-0.5	1.4	-0.6	2.0	-0.4	-0.1	0.6
Whole body fat-free mass	0.2	1.2	5.0	0.1	0.8	0.7	2.2	-0.8	0.5	1.0
Leg fat-free mass (right)	0.3	1.5	6.2	0.1	-0.3	0.7	2.5	-1.4	0.8	1.0
Arm fat percentage (left)	0.5	1.9	4.8	-0.3	-2.2	0.6	1.2	-2.0	1.0	1.1
Average weekly red wine intake	0.9	1.3	2.8	-0.1	1.2	1.7	0.8	1.3	1.5	0.5
Handedness (chirality/laterality): Left-handed	2.6	3.2	7.5	-2.7	0.3	-2.3	0.6	1.7	-2.1	-1.2
Mood swings	0.9	1.7	3.8	2.0	-0.6	1.7	-1.8	-1.2	-0.0	0.3
Loneliness, isolation	1.0	1.4	4.9	0.7	-0.7	-0.8	-1.1	-2.2	-1.2	-0.6
Long-standing illness, disability or infirmity	1.0	1.5	3.7	-1.7	-0.9	-1.9	0.3	-0.2	-1.0	-1.3
Ever had bowel cancer screening	1.0	1.2	3.7	0.4	-0.1	-1.0	-1.9	-1.8	-0.5	-0.1
Diabetes diagnosed by doctor	0.3	0.5	1.4	-1.2	0.8	-1.0	0.5	0.1	-0.2	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.9	-1.4	0.7	-0.8	0.5	1.3	-0.7	-0.4
Friendships satisfaction	0.4	0.5	1.7	-0.1	-0.2	-0.9	1.3	-0.2	0.9	-0.2
Qualifications: nursing, teaching	0.4	0.7	1.9	-0.8	0.8	0.4	1.4	-0.3	1.0	0.4
Commuting to job workplace: Walk	0.1	0.1	0.3	0.2	-0.2	0.5	-0.4	0.3	0.3	-0.4
Eye problems/disorders: Cataract	0.5	0.5	1.6	-1.3	0.5	0.1	1.1	0.7	-0.2	0.1
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.6	0.2	1.6	1.0	0.9	1.4	0.7	0.2
Medication for cholesterol	0.2	0.2	0.6	0.2	0.8	0.4	0.2	-0.1	0.8	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.4	7.2	0.3	-0.3	1.1	2.7	-1.1	2.1	1.6
Back pain experienced in last month	1.5	2.1	6.7	-2.6	-0.0	-1.2	2.1	0.2	-1.4	-0.8
Mineral and other dietary supplements	1.3	1.8	4.5	-1.4	-0.2	-1.8	-0.6	-0.1	-2.1	-1.5
Breast cancer (self-reported)	0.7	0.8	4.0	0.9	-0.4	0.4	-2.0	-0.1	-0.5	-0.4
Asthma (self-reported)	0.3	0.6	2.1	-0.7	1.0	-0.3	0.6	1.4	-0.5	-0.1
Osteoporosis (self-reported)	0.9	1.2	3.1	0.2	-0.4	1.5	-1.8	-0.9	1.2	0.6
Osteoarthritis (self-reported)	1.2	1.6	5.2	0.0	-1.7	-0.8	-1.1	-2.3	-0.9	-0.3
Medication: Aspirin	1.4	1.8	6.2	-1.0	-2.5	-1.6	0.6	-1.1	-0.3	-1.3
Medication: Gliclazide	0.3	0.3	1.5	-0.0	0.8	-1.2	0.2	0.3	0.3	0.0
Illnesses of father: None of the above (group 1)	0.2	0.2	0.8	-0.2	0.1	-0.1	0.9	0.2	0.5	0.6
Smoking status: Current	0.7	1.1	3.2	0.4	-1.5	0.7	-1.8	-1.3	-0.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	5.6	-0.2	-2.4	-0.7	-0.8	-2.3	-0.4	-1.2
Whole body water mass	0.2	1.1	5.1	0.0	0.8	0.6	2.3	-0.9	0.3	0.9
Leg predicted mass (right)	0.3	1.5	6.7	0.1	-0.2	0.7	2.6	-1.3	0.8	1.0
Arm fat mass (left)	0.4	1.7	4.0	-0.1	-1.7	0.6	1.6	-2.0	0.8	1.0
Number of self-reported non-cancer illnesses	0.8	1.4	3.5	-0.5	-1.7	-1.9	-0.6	-1.3	-0.9	-0.3
Average weekly champagne plus white wine intake	0.5	0.7	1.9	-0.3	0.5	1.1	0.7	-0.4	0.8	1.4
Miserableness	0.8	1.4	3.1	1.1	-1.5	0.7	1.6	-1.7	0.0	0.4
Guilty feelings	1.8	2.8	6.0	1.4	0.8	2.3	2.5	-0.6	1.9	1.2
Wears glasses or contact lenses	0.4	0.5	1.4	-0.3	-1.2	0.9	0.3	-0.7	-0.5	-0.5
Ever taken oral contraceptive pill	0.9	1.0	4.4	0.4	-0.8	0.4	-2.1	-1.0	-0.7	-0.1
Hearing aid user	0.7	0.8	1.5	-0.8	0.9	-1.0	0.2	0.8	-1.0	-1.2
Mother’s age at death	0.9	1.1	4.0	0.3	-0.7	0.2	-1.2	0.2	-1.4	-2.0
Financial situation satisfaction	0.7	0.8	1.9	1.1	0.9	0.1	1.4	-0.1	1.1	0.8
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.9	0.1	-0.1	-0.9	0.1	0.3	0.8	-1.4
Commuting to job workplace: Public transport	0.3	0.4	1.2	0.6	1.1	0.1	-0.4	0.0	0.9	0.7
Eye problems/disorders: Glaucoma	1.5	1.8	6.4	-1.3	0.5	-1.6	0.8	0.9	-2.5	-0.6
Medication: Blood pressure	0.5	1.0	2.6	-1.6	-0.8	-1.1	1.1	0.1	-1.1	-0.6
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.5	0.8	1.0	0.4	1.9	0.3	1.1	1.9
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.6	-0.1	-0.3	1.3	0.9	0.8	0.7	-0.0
High cholesterol (Self-reported)	2.5	4.3	15.4	1.2	-2.6	0.6	-2.1	-3.9	1.5	0.3
Medication: Bendroflumethiazide	0.8	1.2	3.3	-1.2	-1.8	-0.7	0.5	-0.6	-0.9	-1.3
Medication: Paracetamol	0.9	1.3	4.2	0.2	0.4	-0.1	1.3	-0.1	1.8	2.0
Medication: Lisinopril	1.7	2.2	8.0	-2.4	-0.8	0.4	2.8	-0.0	-0.5	-0.5
Medication: Atorvastatin	1.0	1.2	3.8	1.3	-0.6	0.1	-1.5	-1.9	0.5	-0.0
Illnesses of father: High blood pressure	1.3	1.6	3.5	0.2	-1.3	-0.1	-1.2	-1.7	-1.9	-1.2
Alcohol drinker status: Never	0.6	0.8	2.0	-0.1	1.1	0.7	-0.2	0.9	-1.4	-0.9
Ever smoked	0.9	1.6	5.0	2.0	-1.0	2.2	-0.8	0.0	0.9	0.4
Basal metabolic rate	0.2	1.3	5.7	0.1	0.6	0.7	2.4	-1.0	0.6	1.1
Leg fat percentage (left)	0.1	0.3	0.9	-0.3	-0.6	0.4	0.3	-0.5	0.5	0.9
Arm fat-free mass (left)	0.2	1.2	4.2	0.3	1.4	0.8	2.1	-0.3	0.6	1.1
Number of operations (self-reported)	0.2	0.2	1.2	-0.1	-0.3	-0.5	1.1	-0.1	0.2	0.2
Average weekly beer plus cider intake	1.1	1.6	3.9	0.9	2.0	0.8	-1.6	1.8	-0.2	-0.4
Irritability	1.1	1.9	5.7	0.4	-1.0	-0.4	-2.4	-1.2	-1.8	-1.3
Risk taking	0.9	1.3	3.0	1.2	0.4	1.2	-1.6	-1.7	0.7	0.3
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.4	-0.8	0.7	-0.9	1.2	-0.4	-0.5	-0.7
Fractured/broken bones in last 5 years	0.4	0.6	2.0	-0.3	0.9	-0.1	-0.7	1.4	0.5	0.5
Age started oral contraceptive pill	1.2	1.5	3.5	-1.5	-0.9	-1.3	0.3	1.9	-1.3	-0.8
Diastolic blood pressure, automated reading	0.5	1.4	4.0	-0.8	-1.0	0.7	-0.6	-1.1	-1.6	-2.0
Ever depressed for a whole week	0.5	0.6	3.1	0.2	0.8	1.8	0.4	-0.6	-0.4	0.0
Unable to work because of sickness or disability	0.6	0.8	2.4	0.4	1.6	0.7	0.6	0.7	1.2	0.3
Commuting to job workplace: Cycle	1.4	1.7	5.7	0.1	-2.3	-0.8	-0.2	-2.4	-0.1	0.5
Myopia	2.3	3.3	6.3	-1.6	-2.3	-1.3	-2.3	0.3	-1.4	-2.5
Vascular/heart problems diagnosed by doctor	0.8	2.2	4.8	2.1	2.2	1.0	-0.1	1.5	1.4	1.1
Cholesterol lowering medication	1.2	1.7	4.8	0.6	-2.2	0.7	-1.6	-1.6	-0.5	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	3.1	-0.0	0.4	-1.8	-1.5	0.0	-1.1	-0.8
Pain experienced in last month	0.5	0.8	2.2	1.5	0.8	1.2	0.1	0.9	0.5	0.1
Supplements: Calcium	1.0	1.1	3.8	0.3	1.1	0.4	-0.6	1.9	1.4	-0.0
Basal cell carcinoma (self-reported)	2.6	3.1	7.5	2.3	-0.8	2.3	-2.7	-1.4	0.7	0.6
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.0	0.1	-1.4	1.1	0.2	-1.0	1.3	0.7
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.8	0.1	-0.9	-0.0	0.5	-0.1	-0.1	0.1
Heart disease (siblings)	1.6	2.0	10.0	0.0	-1.2	0.4	-3.2	-1.3	-0.8	-0.4
Alcohol drinker status: Previous	0.3	0.4	0.8	-0.6	0.1	-0.5	-0.9	-0.5	-0.4	-0.9
Pack years of smoking	0.4	0.6	1.4	-1.2	-0.6	-0.4	-0.5	-0.6	-1.1	-0.9
Impedance of whole body	0.2	0.9	2.6	-0.4	1.6	0.9	-0.0	1.6	-0.2	0.4
Leg fat mass (left)	0.2	0.8	1.6	-0.2	-0.7	0.9	1.2	-1.1	0.7	1.1
Arm predicted mass (left)	0.2	1.1	4.3	0.4	1.1	0.7	2.1	-0.6	0.5	1.1