[Hub]/) : Traits : Rheumatoid Arthritis : ← →

chr1:113,236,087-115,222,434

Best TWAS P=8.56e-49 · Best GWAS P=1.66e-102 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MAGI3	0.06	0.00	blup	554	0.03	1.9e-04	4.19	-8.3	1.1e-16	-0.33	0.74	0.01	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PHTF1	0.07	0.06	blup	517	0.05	1.2e-06	10.25	-8.7	4.6e-18	-0.32	0.99	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PTPN22	0.09	0.11	lasso	2	0.12	2.7e-14	10.43	6.6	5.1e-11	0.19	1.00	0.00	FALSE
4	GTEx	Artery Aorta	RP4-730K3.3	0.14	0.00	lasso	7	0.00	7.0e-01	1.59	7.3	2.5e-13	0.24	0.10	0.08	FALSE
5	GTEx	Artery Tibial	AP4B1	0.09	0.13	lasso	1	0.13	4.0e-10	-5.49	5.5	4.1e-08	0.14	1.00	0.00	FALSE
6	GTEx	Artery Tibial	HIPK1	0.13	0.00	enet	39	0.00	1.3e-01	-3.46	6.8	1.2e-11	0.16	0.04	0.40	FALSE
7	GTEx	Artery Tibial	AP4B1-AS1	0.14	0.13	lasso	2	0.12	4.9e-10	-5.49	5.5	3.3e-08	0.14	1.00	0.00	FALSE
8	GTEx	Brain Cerebellar Hemisphere	AP4B1	0.29	0.22	lasso	5	0.14	1.8e-04	-5.74	6.2	7.8e-10	0.14	0.26	0.04	FALSE
9	GTEx	Breast Mammary Tissue	DCLRE1B	0.19	0.02	lasso	5	0.03	9.1e-03	10.29	-10.3	9.1e-25	-0.39	0.27	0.37	FALSE
10	GTEx	Cells Transformed fibroblasts	OLFML3	0.12	0.00	enet	23	0.00	3.0e-01	-5.24	-7.3	2.8e-13	-0.39	0.04	0.49	FALSE
11	GTEx	Cells Transformed fibroblasts	PHTF1	0.22	0.09	lasso	5	0.19	2.2e-14	13.37	-10.0	9.5e-24	-0.47	1.00	0.00	FALSE
12	GTEx	Cells Transformed fibroblasts	DCLRE1B	0.06	0.04	lasso	5	0.02	1.5e-02	10.46	-8.6	9.8e-18	-0.33	0.36	0.02	FALSE
13	GTEx	Cells Transformed fibroblasts	AP4B1-AS1	0.12	0.09	lasso	6	0.10	4.1e-08	10.33	-7.8	9.5e-15	-0.27	0.99	0.00	FALSE
14	GTEx	Colon Transverse	PTPN22	0.19	0.16	lasso	5	0.21	2.5e-10	10.43	7.4	1.1e-13	0.24	1.00	0.00	TRUE
15	GTEx	Esophagus Gastroesophageal Junction	AP4B1	0.13	0.00	lasso	4	0.01	2.0e-01	-6.18	-11.1	1.9e-28	-0.47	0.10	0.19	FALSE
16	GTEx	Muscle Skeletal	HIPK1	0.07	0.00	enet	23	0.02	9.5e-03	5.09	-7.8	5.9e-15	-0.27	0.23	0.07	FALSE
17	GTEx	Nerve Tibial	AP4B1-AS1	0.17	0.09	lasso	3	0.07	8.2e-06	-5.49	6.1	1.4e-09	0.12	0.75	0.03	FALSE
18	GTEx	Testis	RSBN1	0.09	0.09	enet	6	0.09	8.9e-05	10.36	-10.7	1.6e-26	-0.37	0.51	0.08	FALSE
19	GTEx	Testis	AP4B1-AS1	0.21	0.19	lasso	5	0.19	5.9e-09	-5.74	5.5	2.9e-08	0.13	1.00	0.00	FALSE
20	METSIM	Adipose	MAGI3	0.04	0.01	blup	549	0.03	5.5e-05	0.19	-7.4	1.4e-13	-0.31	0.74	0.01	FALSE
21	METSIM	Adipose	PHTF1	0.10	0.03	blup	517	0.04	1.1e-06	-1.19	-8.5	1.8e-17	-0.36	0.83	0.09	TRUE
22	ROSMAP	Brain Pre-frontal Cortex	OLFML3	0.10	0.02	enet	27	0.04	9.7e-06	10.92	-10.0	1.4e-23	-0.35	0.86	0.05	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	DCLRE1B	0.08	0.04	enet	14	0.05	2.6e-07	13.73	-13.1	5.0e-39	-0.50	0.97	0.03	FALSE
24	YFS	Blood	PHTF1	0.03	0.02	enet	12	0.02	1.3e-06	-6.18	-5.9	3.2e-09	-0.24	0.50	0.01	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	DCLRE1B	0.02	0.00	blup	39	0.01	5.2e-03	10.23	-12.5	7.9e-36	-0.47	0.01	0.45	TRUE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	PHTF1	0.05	0.02	enet	7	0.03	3.1e-07	13.37	-10.5	1.2e-25	-0.48	0.22	0.63	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	PTPN22	0.02	0.01	blup	67	0.01	9.6e-03	13.48	13.1	3.5e-39	0.57	0.11	0.37	FALSE
28	The Cancer Genome Atlas	Esophageal Carcinoma	DCLRE1B	0.13	0.02	blup	39	0.08	1.8e-03	-4.95	-11.1	9.8e-29	-0.46	0.01	0.54	FALSE
29	The Cancer Genome Atlas	Glioblastoma Multiforme	DCLRE1B	0.20	-0.01	blup	39	0.04	3.0e-02	13.73	-13.7	1.1e-42	-0.54	0.00	0.52	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PHTF1	0.36	0.09	lasso	8	0.12	3.5e-13	-1.36	-6.5	8.8e-11	-0.35	1.00	0.00	FALSE
31	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	BCL2L15	0.09	0.00	blup	42	0.04	1.1e-02	10.43	11.4	3.4e-30	0.37	0.02	0.05	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	PHTF1	0.08	0.03	blup	62	0.05	2.1e-06	12.53	-7.9	3.9e-15	-0.39	0.75	0.01	TRUE
33	The Cancer Genome Atlas	Thyroid Carcinoma	DCLRE1B	0.06	0.04	enet	11	0.04	4.3e-05	13.48	-14.7	8.6e-49	-0.58	0.01	0.98	TRUE