[Hub]/) : Traits : Rheumatoid Arthritis :

chr1:113,236,087-115,222,434

Best TWAS P=8.56e-49 · Best GWAS P=1.66e-102 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex MAGI3 0.06 0.00 blup 554 0.03 1.9e-04 4.19 -8.3 1.1e-16 -0.33 0.74 0.01 FALSE
2 CommonMind Brain Pre-frontal Cortex PHTF1 0.07 0.06 blup 517 0.05 1.2e-06 10.25 -8.7 4.6e-18 -0.32 0.99 0.00 FALSE
3 CommonMind Brain Pre-frontal Cortex PTPN22 0.09 0.11 lasso 2 0.12 2.7e-14 10.43 6.6 5.1e-11 0.19 1.00 0.00 FALSE
4 GTEx Artery Aorta RP4-730K3.3 0.14 0.00 lasso 7 0.00 7.0e-01 1.59 7.3 2.5e-13 0.24 0.10 0.08 FALSE
5 GTEx Artery Tibial AP4B1 0.09 0.13 lasso 1 0.13 4.0e-10 -5.49 5.5 4.1e-08 0.14 1.00 0.00 FALSE
6 GTEx Artery Tibial HIPK1 0.13 0.00 enet 39 0.00 1.3e-01 -3.46 6.8 1.2e-11 0.16 0.04 0.40 FALSE
7 GTEx Artery Tibial AP4B1-AS1 0.14 0.13 lasso 2 0.12 4.9e-10 -5.49 5.5 3.3e-08 0.14 1.00 0.00 FALSE
8 GTEx Brain Cerebellar Hemisphere AP4B1 0.29 0.22 lasso 5 0.14 1.8e-04 -5.74 6.2 7.8e-10 0.14 0.26 0.04 FALSE
9 GTEx Breast Mammary Tissue DCLRE1B 0.19 0.02 lasso 5 0.03 9.1e-03 10.29 -10.3 9.1e-25 -0.39 0.27 0.37 FALSE
10 GTEx Cells Transformed fibroblasts OLFML3 0.12 0.00 enet 23 0.00 3.0e-01 -5.24 -7.3 2.8e-13 -0.39 0.04 0.49 FALSE
11 GTEx Cells Transformed fibroblasts PHTF1 0.22 0.09 lasso 5 0.19 2.2e-14 13.37 -10.0 9.5e-24 -0.47 1.00 0.00 FALSE
12 GTEx Cells Transformed fibroblasts DCLRE1B 0.06 0.04 lasso 5 0.02 1.5e-02 10.46 -8.6 9.8e-18 -0.33 0.36 0.02 FALSE
13 GTEx Cells Transformed fibroblasts AP4B1-AS1 0.12 0.09 lasso 6 0.10 4.1e-08 10.33 -7.8 9.5e-15 -0.27 0.99 0.00 FALSE
14 GTEx Colon Transverse PTPN22 0.19 0.16 lasso 5 0.21 2.5e-10 10.43 7.4 1.1e-13 0.24 1.00 0.00 TRUE
15 GTEx Esophagus Gastroesophageal Junction AP4B1 0.13 0.00 lasso 4 0.01 2.0e-01 -6.18 -11.1 1.9e-28 -0.47 0.10 0.19 FALSE
16 GTEx Muscle Skeletal HIPK1 0.07 0.00 enet 23 0.02 9.5e-03 5.09 -7.8 5.9e-15 -0.27 0.23 0.07 FALSE
17 GTEx Nerve Tibial AP4B1-AS1 0.17 0.09 lasso 3 0.07 8.2e-06 -5.49 6.1 1.4e-09 0.12 0.75 0.03 FALSE
18 GTEx Testis RSBN1 0.09 0.09 enet 6 0.09 8.9e-05 10.36 -10.7 1.6e-26 -0.37 0.51 0.08 FALSE
19 GTEx Testis AP4B1-AS1 0.21 0.19 lasso 5 0.19 5.9e-09 -5.74 5.5 2.9e-08 0.13 1.00 0.00 FALSE
20 METSIM Adipose MAGI3 0.04 0.01 blup 549 0.03 5.5e-05 0.19 -7.4 1.4e-13 -0.31 0.74 0.01 FALSE
21 METSIM Adipose PHTF1 0.10 0.03 blup 517 0.04 1.1e-06 -1.19 -8.5 1.8e-17 -0.36 0.83 0.09 TRUE
22 ROSMAP Brain Pre-frontal Cortex OLFML3 0.10 0.02 enet 27 0.04 9.7e-06 10.92 -10.0 1.4e-23 -0.35 0.86 0.05 FALSE
23 ROSMAP Brain Pre-frontal Cortex DCLRE1B 0.08 0.04 enet 14 0.05 2.6e-07 13.73 -13.1 5.0e-39 -0.50 0.97 0.03 FALSE
24 YFS Blood PHTF1 0.03 0.02 enet 12 0.02 1.3e-06 -6.18 -5.9 3.2e-09 -0.24 0.50 0.01 FALSE
25 The Cancer Genome Atlas Breast Invasive Carcinoma DCLRE1B 0.02 0.00 blup 39 0.01 5.2e-03 10.23 -12.5 7.9e-36 -0.47 0.01 0.45 TRUE
26 The Cancer Genome Atlas Breast Invasive Carcinoma PHTF1 0.05 0.02 enet 7 0.03 3.1e-07 13.37 -10.5 1.2e-25 -0.48 0.22 0.63 FALSE
27 The Cancer Genome Atlas Breast Invasive Carcinoma PTPN22 0.02 0.01 blup 67 0.01 9.6e-03 13.48 13.1 3.5e-39 0.57 0.11 0.37 FALSE
28 The Cancer Genome Atlas Esophageal Carcinoma DCLRE1B 0.13 0.02 blup 39 0.08 1.8e-03 -4.95 -11.1 9.8e-29 -0.46 0.01 0.54 FALSE
29 The Cancer Genome Atlas Glioblastoma Multiforme DCLRE1B 0.20 -0.01 blup 39 0.04 3.0e-02 13.73 -13.7 1.1e-42 -0.54 0.00 0.52 FALSE
30 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PHTF1 0.36 0.09 lasso 8 0.12 3.5e-13 -1.36 -6.5 8.8e-11 -0.35 1.00 0.00 FALSE
31 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma BCL2L15 0.09 0.00 blup 42 0.04 1.1e-02 10.43 11.4 3.4e-30 0.37 0.02 0.05 FALSE
32 The Cancer Genome Atlas Prostate Adenocarcinoma PHTF1 0.08 0.03 blup 62 0.05 2.1e-06 12.53 -7.9 3.9e-15 -0.39 0.75 0.01 TRUE
33 The Cancer Genome Atlas Thyroid Carcinoma DCLRE1B 0.06 0.04 enet 11 0.04 4.3e-05 13.48 -14.7 8.6e-49 -0.58 0.01 0.98 TRUE