Hub : Genes

RHOBTB1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.404	0.063	1.6e-10	0.115	0.129	0.150	0.15	0.145	7.9e-14	1.9e-15	8.5e-18	7.6e-18	2.9e-17
2	GTEx	Testis	0.174	0.055	1.4e-04	0.091	NA	0.146	NA	0.158	7.4e-05	NA	5.0e-07	NA	1.7e-07
3	TCGA	Stomach Adenocarcinoma	0.075	0.038	8.9e-03	-0.003	0.017	0.001	NA	0.001	6.5e-01	2.1e-02	2.8e-01	NA	2.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	1.0	1.6	0.1	-1.3	1.1
Bipolar Disorder or Schizophrenia	0.3	0.8	1.7	0.1	-0.8	1.3
Depressed Affect (Nagel 2018)	1.7	3.6	9.1	0.6	3.0	-1.2
Depression (Nagel 2018)	4.2	6.4	14.7	0.8	3.8	-2.0
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.4	1.6	-0.6	-0.0
Neuroticism (Nagel 2018)	0.3	0.7	1.8	-0.2	1.4	-0.5
Schizophrenia (2018)	0.1	0.2	0.5	0.0	0.0	0.7
Schizophrenia vs Biploar Disorder	1.9	2.4	5.4	-1.2	2.3	0.7
Worry (Nagel 2018)	0.2	0.5	1.0	-1.0	0.5	0.5
Alzheimer’s Disease (in mother)	2.1	2.5	3.5	-1.4	-1.4	1.9
Alzheimer’s Disease (in father)	0.9	1.0	1.5	1.2	1.1	-0.3
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	-0.6	-0.1	0.9
Crohns Disease (2017)	0.4	0.8	2.0	-0.5	-1.4	-0.3
Irritable Bowel Disease (IBD)	1.2	2.8	5.2	-1.2	-2.3	1.3
Ulcerative Colitis (UC)	1.6	2.9	4.7	-0.8	-2.2	1.8
Major Depression (MDD)	1.0	1.3	3.1	-0.0	1.8	-0.8
Reaction Time	0.2	0.4	1.2	-0.0	-0.2	-1.1
Verbal and Numeric Reasoning (VNR)	0.8	1.8	3.5	1.4	-1.9	-0.3
Breast Cancer	0.3	0.6	1.2	-1.1	0.1	0.9
Ovarian Cancer	1.0	1.3	3.8	0.2	-1.9	0.4
Prostate Cancer	1.2	1.6	3.5	1.9	-1.1	0.2
Age at First Birth	0.5	0.8	2.3	1.5	-0.2	-0.1
Bipolar Disorder (2011)	2.3	2.2	3.3	-0.6	-1.7	1.8
Body Mass Index (BMI) (2010)	3.3	4.5	8.2	0.5	2.9	-2.3
Coronary Artery Disease (CAD)	0.9	1.1	1.2	0.9	-1.1	-1.1
Crohns Disease (2012)	0.3	0.6	1.3	0.6	0.1	-1.1
Mean Putamen Volume	0.6	0.6	1.6	-0.3	1.2	-0.5
Fasting Glucose	0.2	0.2	0.5	-0.1	-0.7	-0.3
HbA1C	0.6	0.7	1.5	-1.2	-0.6	-0.6
HDL Cholesterol	1.1	1.8	2.4	-1.4	1.0	1.5
LDL Cholesterol	0.1	0.1	0.3	-0.2	0.5	-0.1
Lupus	1.2	1.9	5.0	2.2	0.7	0.4
Neuroticism (2016)	1.2	1.7	2.9	-1.7	-1.1	1.1
Primary Biliary Cirrhosis	0.2	0.2	0.3	0.5	-0.3	-0.6
Rheumatoid Arthritis	0.1	0.1	0.2	-0.4	-0.4	-0.2
Schizophrenia (2014)	0.1	0.3	0.7	0.3	0.1	0.9
Triglycerides	0.1	0.1	0.3	-0.0	-0.3	-0.5
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.5	-0.1	0.9	-1.6
Ulcerative Colitis	0.2	0.3	0.5	-0.4	-0.5	0.7
Blood Eosinophil Count	0.2	1.8	3.1	-1.5	-0.5	1.8
Blood Platelet Count	0.7	8.0	20.2	1.7	4.5	-0.9
Blood Red Count	0.0	0.0	0.0	-0.2	-0.2	-0.0
Blood White Count	0.3	2.5	4.5	2.1	1.7	-0.6
Heel T-Score	0.7	5.4	9.3	-0.1	-2.6	-3.0
BMI	1.4	8.0	17.2	1.3	4.2	-2.3
Height	0.3	6.5	10.8	-1.6	-3.3	2.5
Waist Hip Ratio (WHR)	0.3	1.2	2.5	-0.2	-1.0	1.6
Systolic Blood Pressure	1.9	9.3	27.9	-0.2	-5.3	0.3
Smoking Status	0.2	0.4	1.1	0.4	1.0	0.3
Allergy or Eczema	0.6	1.6	2.7	-1.5	-1.6	-0.2
Cardiovascular Disease	0.6	2.0	3.6	-1.0	-1.9	-1.1
Hypothyroidism (self reported)	0.4	1.0	1.5	-1.2	-1.2	0.2
Respiratory disease	0.3	0.6	1.0	-1.0	0.5	0.8
Type 2 Diabetes (T2D) (2018)	0.8	1.4	2.2	-0.8	-1.5	1.2
Lung FEV1/FVC ratio	0.6	2.9	8.5	-2.9	0.5	-0.3
Lung FVC	1.1	5.4	7.4	2.7	-1.6	2.5
Neuroticism	0.3	0.8	1.6	-0.8	1.3	0.3
Chronotype (morning person)	0.2	0.4	1.0	1.0	0.2	-0.1
Hair Pigment	0.0	0.1	0.4	0.0	0.2	0.6
Tanning	0.1	1.6	3.2	1.0	0.8	1.8
Hand grip strength (left)	0.1	0.3	0.6	0.8	-0.4	-0.2
Number of treatments/medications taken	1.0	1.8	4.2	-0.4	1.1	-2.0
Average weekly spirits intake	0.2	0.2	0.5	-0.5	-0.7	0.1
Sensitivity / hurt feelings	1.5	2.6	3.4	-1.8	-1.5	1.4
Frequency of depressed mood in last 2 weeks	2.9	4.1	12.1	-0.3	3.5	0.0
Hearing difficulty/problems: Yes	0.9	1.4	1.8	1.4	1.1	-1.1
Relative age of first facial hair	1.0	2.1	5.3	0.9	-0.1	-2.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.2	0.6	-1.1	-0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.6	-0.1	0.8	-0.8
Ever had hysterectomy (womb removed)	1.4	1.6	3.2	0.3	1.2	-1.8
Systolic blood pressure, automated reading	1.2	3.6	10.7	-0.3	-3.3	-0.2
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.1	-0.0	-1.5	0.9
Angina	0.5	0.7	1.5	0.5	-1.2	-0.6
Medication for hormone replacement therapy	1.1	1.2	3.0	0.1	1.7	-0.8
Vitamin and mineral supplements	1.5	2.1	4.8	-1.2	-2.2	-0.2
Supplements: Zinc	0.2	0.2	0.6	0.8	0.0	-0.2
Medication: Co-codamol	0.2	0.2	0.3	-0.5	0.5	-0.1
Medication: Metformin	0.6	0.9	1.1	-0.9	-0.9	1.1
Diabetes (father)	0.3	0.3	0.6	0.5	-0.2	0.8
Diabetes (mother)	1.1	1.4	2.4	-0.1	1.5	1.3
Severe depression (siblings)	1.2	1.4	2.5	1.0	-0.8	-1.6
Pack years adult smoking proportion	1.3	1.9	3.6	0.9	1.9	-1.2
Impedance of leg (right)	1.4	6.8	15.3	-2.1	-3.9	0.8
Leg fat-free mass (left)	0.9	4.5	9.3	1.7	3.1	-1.2
Trunk fat percentage	1.0	3.9	7.7	0.2	2.0	-2.8
Hand grip strength (right)	0.1	0.3	0.6	0.7	0.8	0.2
Townsend deprivation index at recruitment	0.6	0.9	2.4	-0.3	1.6	-0.5
Current tobacco smoking	1.4	2.3	5.8	-0.2	2.4	-1.1
Average weekly fortified wine intake	1.0	1.2	2.2	-0.6	1.5	1.0
Maternal smoking around birth	1.6	2.3	6.0	0.4	2.5	-0.9
Fed-up feelings	1.5	2.7	7.4	0.4	2.7	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	4.6	1.4	2.1	-0.8
Relative age voice broke	0.8	1.3	2.0	0.7	-1.4	-1.2
Taking other prescription medications	0.9	1.5	2.4	1.1	0.8	-1.6
Age when periods started (menarche)	0.6	1.5	3.6	0.7	-1.9	0.6
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	1.9	-0.0	1.4	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	5.0	-2.2	0.2	-1.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	0.7	0.4	-0.3
Qualifications: CSEs or equivalent	1.0	1.3	2.3	-1.2	1.5	0.6
Serious illness, injury or assault to yourself	0.3	0.4	0.7	-0.8	-0.3	-0.7
High blood pressure	0.8	2.3	6.3	0.0	-0.9	-2.5
Hayfever, allergic rhinitis or eczema	0.5	1.1	1.7	-1.0	-1.3	-0.7
Multivitamins +/- minerals	4.0	5.0	10.8	2.0	3.3	-0.7
Stomach or abdominal pain in last month	0.2	0.3	0.7	-0.3	0.1	0.8
Supplements: Glucosamine	1.4	1.9	3.1	-1.4	0.8	1.8
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.0	0.2	1.4	-0.9
Medication: Atenolol	0.3	0.4	0.6	-0.6	-0.4	0.8
Medication: Levothyroxine sodium	0.3	0.5	0.6	-0.8	0.7	-0.5
Sitting height	0.0	0.0	0.0	0.1	-0.1	-0.1
Chronic bronchitis/emphysema (father)	2.1	2.5	6.7	-0.9	0.1	-2.6
High blood pressure (mother)	0.4	0.6	0.9	0.8	-0.9	-0.6
Body mass index (BMI)	1.8	7.7	16.2	1.4	4.0	-2.2
Impedance of leg (left)	1.6	7.7	17.5	-2.2	-4.2	1.0
Leg predicted mass (left)	0.8	4.4	9.2	1.6	3.0	-1.2
Trunk fat mass	1.0	4.2	6.2	0.6	2.5	-2.5
Waist circumference	1.0	3.6	6.2	1.2	2.5	-1.8
Number of incorrect matches in round	1.2	1.9	5.4	-2.3	0.1	0.6
Past tobacco smoking	0.4	0.8	1.6	-1.3	0.7	-0.6
Alcohol usually taken with meals	0.6	0.9	2.0	0.1	-0.9	1.4
Nervous feelings	0.2	0.3	0.7	-0.5	-0.8	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.7	-0.0	1.9	-0.8
Hearing difficulty/problems with background noise	1.1	1.8	3.7	1.9	0.9	1.0
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	-0.1	-0.3	0.1
Had menopause	0.8	1.0	2.3	-1.5	-0.9	0.1
Had other major operations	0.2	0.2	0.4	0.4	-0.4	-0.7
Forced vital capacity (FVC)	1.0	3.8	7.8	1.5	-1.1	2.8
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	2.1	-1.3	-0.7	-1.4
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.0	-0.8	0.9	-1.0
Qualifications: None of the above	5.0	10.7	14.6	2.5	3.8	-3.4
Financial difficulties in last 2 years	2.1	2.9	4.9	-0.0	1.9	-2.2
Mouth/teeth dental problems	0.4	0.5	1.1	0.7	-1.0	0.2
Heart attack	1.9	2.4	6.6	2.6	-0.5	-0.6
Allergy	0.3	0.7	1.0	0.9	0.5	1.0
Pain all over the body in last month	0.9	0.9	2.4	-1.5	-0.5	-0.4
Diabetes (self-reported)	0.6	0.9	1.5	-1.2	-0.5	0.9
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	4.5	-0.5	-2.1	1.3
Medication: Ramipril	0.5	0.6	1.4	-0.4	0.5	-1.2
Medication: Simvastatin	0.9	1.3	1.8	-0.9	-1.1	-1.4
Fluid intelligence score	0.7	1.5	3.5	0.9	-1.9	0.3
Illnesses of siblings	0.5	0.7	2.1	-0.3	-0.0	1.5
Neuroticism score	0.4	0.8	1.3	-1.0	0.4	1.2
Weight	0.9	4.5	9.2	1.4	3.0	-1.5
Impedance of arm (right)	0.6	3.0	8.4	-0.7	-2.9	0.3
Arm fat percentage (right)	1.2	4.6	8.8	0.9	3.0	-2.1
Trunk fat-free mass	0.7	3.8	9.4	1.4	3.1	0.5
Hip circumference	0.7	3.0	4.4	0.9	2.0	-2.1
Time employed in main current job	0.9	1.1	1.6	-0.9	1.3	0.9
Alcohol intake versus 10 years previously	1.7	2.6	6.3	-1.2	2.5	0.0
Father’s age at death	0.6	0.9	2.0	-0.1	-1.4	0.8
Worrier / anxious feelings	2.8	5.2	11.4	-3.4	-1.5	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	4.7	-0.5	2.2	-0.5
Falls in the last year	2.3	3.1	7.2	-0.2	1.5	-2.7
Hair/balding pattern: Pattern 3	1.1	1.6	3.5	0.9	-1.9	-0.6
Number of live births	1.0	1.4	3.5	1.9	0.7	-0.6
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	7.4	0.6	-0.8	2.7
Pulse rate	2.5	4.1	8.9	1.4	3.0	-1.3
Happiness	0.9	1.0	3.1	-0.1	1.7	-0.2
Noisy workplace	2.1	2.6	4.5	0.2	1.8	-2.1
Qualifications: A levels/AS levels or equivalent	2.1	4.6	13.2	0.3	-3.6	-0.8
Serious illness, injury or assault of a close relative in last 2 years	3.7	4.2	8.5	1.8	0.9	-2.9
Mouth/teeth dental problems: Dentures	5.7	9.6	18.9	2.6	4.3	-1.8
Asthma	0.2	0.4	1.2	-1.1	-0.2	0.3
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	3.3	-1.8	1.7	-0.9
Medication: Cholesterol lowering	0.8	1.2	2.1	-1.2	-1.4	-0.2
Depression (self-reported)	0.9	1.0	2.1	-1.5	1.0	-0.2
Medication: Lansoprazole	0.5	0.5	0.6	0.8	-0.8	-0.6
Prospective memory result	2.6	3.2	6.0	0.8	2.5	-1.7
Lung cancer (father)	1.0	1.2	2.5	-1.6	-1.0	0.2
Illnesses of mother	0.8	1.0	3.0	0.2	1.7	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	6.3	0.8	-0.6	2.5
Pulse wave Arterial Stiffness index	0.8	0.9	1.6	1.1	-0.2	-1.3
Impedance of arm (left)	0.8	3.6	9.9	-1.0	-3.1	0.1
Arm fat mass (right)	1.2	5.1	10.1	1.2	3.2	-1.9
Trunk predicted mass	0.6	3.7	8.9	1.3	3.0	0.5
Standing height	0.1	1.0	1.7	-0.2	-1.3	1.1
Length of working week for main job	2.2	2.5	4.5	1.4	2.1	1.1
Exposure to tobacco smoke at home	2.2	2.5	7.0	0.2	2.7	-0.7
Breastfed as a baby	0.7	0.8	2.0	0.5	-0.5	-1.4
Tense / ‘highly strung’	0.8	1.3	2.0	1.1	0.8	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	4.5	0.1	2.1	-1.3
Hair/balding pattern: Pattern 4	1.4	3.3	9.7	0.4	-3.1	-0.2
Birth weight of first child	0.5	0.9	2.5	0.1	-1.6	0.6
Peak expiratory flow (PEF)	0.6	1.3	2.6	0.8	-0.8	1.6
Pulse wave reflection index	0.6	0.8	0.9	0.9	-0.8	-0.9
Ever highly irritable/argumentative for 2 days	1.9	2.3	4.9	0.9	2.2	-1.1
Loud music exposure frequency	0.5	0.6	1.7	0.2	-0.1	1.3
Qualifications: O levels/GCSEs or equivalent	2.6	4.1	9.9	-0.4	-3.1	1.5
Mouth/teeth dental problems: Bleeding gums	2.7	3.6	5.7	-2.4	-2.1	0.9
Blood clot in the leg (DVT)	0.8	1.0	1.6	1.2	0.3	-1.3
Medication: Paracetamol	0.6	0.9	2.1	-0.3	1.4	-0.8
Headache pain in last month	1.8	3.1	8.4	0.9	2.9	0.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.5	0.1	1.2	0.5
Glaucoma (self-reported)	0.3	0.3	0.6	-0.6	0.1	-0.8
Gout (self-reported)	0.4	0.5	0.8	0.3	0.8	-0.9
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.3	-0.6	0.1	0.1
Medication: Amlodipine	0.9	1.3	2.7	1.6	-0.6	-1.0
Medication: Ventolin 100micrograms inhaler	0.8	1.1	1.7	1.2	0.2	-1.3
Birth weight	0.3	0.6	1.7	0.1	0.5	1.3
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.0	0.2	1.4	-0.7
High blood pressure (siblings)	0.3	0.4	1.3	1.1	0.0	-0.2
Forced vital capacity (FVC), Best measure	0.8	3.0	6.2	1.6	-0.6	2.5
Body fat percentage	1.1	4.3	7.3	0.6	2.3	-2.7
Leg fat percentage (right)	1.1	4.1	6.2	0.5	2.4	-2.5
Arm fat-free mass (right)	0.4	2.1	4.7	1.2	2.2	-0.7
Exposure to tobacco smoke outside home	2.6	3.4	4.6	1.2	2.1	-2.0
Comparative body size at age 10	1.4	3.8	8.4	0.8	2.9	-1.5
Number of full brothers	1.8	2.3	3.0	1.1	1.7	-1.7
Worry too long after embarrassment	1.1	1.8	2.4	-1.2	-1.5	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.4	-0.7	1.5	-1.2
Wheeze or whistling in the chest in last year	0.8	1.5	3.3	-0.0	1.1	-1.8
Number of children fathered	0.1	0.1	0.2	-0.3	-0.5	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.1	0.1	-0.9	1.0
Age at first live birth	0.3	0.6	1.0	-0.9	-1.0	-0.1
Pulse wave peak to peak time	0.8	1.0	1.8	-1.0	-0.1	1.4
Health satisfaction	1.6	2.0	4.9	0.5	2.2	-0.9
Shortness of breath walking on level ground	2.7	3.2	4.4	1.8	1.4	-2.1
Qualifications: College or University degree	0.6	1.8	4.5	-0.4	-2.1	0.9
Eye problems/disorders: None of the above	0.1	0.1	0.1	0.3	-0.1	-0.3
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.9	-0.3	-0.7	-0.9
Emphysema/chronic bronchitis	1.2	1.4	2.7	-1.6	0.1	1.2
Medication for pain relief, constipation, heartburn	0.3	0.6	0.8	0.7	-0.7	0.9
Neck or shoulder pain in last month	2.1	2.9	6.6	1.4	2.6	-0.5
Medication: Blood pressure	0.6	1.0	1.6	1.3	-1.1	-0.5
Angina (self-reported)	0.5	0.7	1.1	0.6	-1.0	-0.7
Migraine (self-reported)	1.0	1.3	3.2	0.8	1.8	0.1
Medication: Ibuprofen	0.8	1.0	1.9	-1.4	1.0	-0.3
Medication: Allopurinol	0.8	1.1	1.7	1.3	0.8	-0.9
Medication: Omeprazole	0.4	0.4	1.2	-0.1	-1.1	-0.3
Medication: Seretide 50 evohaler	1.0	1.2	1.9	-1.4	-0.5	-1.2
Mean time to correctly identify matches	0.5	1.0	3.1	-0.1	-0.1	-1.8
Heart disease (mother)	0.4	0.5	0.6	-0.6	-0.7	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.6	-0.7	1.3	-0.1
Whole body fat mass	1.1	4.6	7.2	0.8	2.7	-2.5
Leg fat mass (right)	1.5	5.8	10.5	1.0	3.2	-2.4
Arm predicted mass (right)	0.4	2.1	5.3	1.0	2.3	-0.3
Pulse rate, automated reading	1.2	4.0	7.6	2.1	2.7	-0.1
Alcohol intake frequency.	2.9	6.6	16.1	1.1	4.0	-1.6
Comparative height size at age 10	0.4	2.4	3.6	-1.7	0.9	1.9
Number of full sisters	0.7	0.9	1.9	1.4	0.7	-0.5
Suffer from ‘nerves’	0.1	0.2	0.4	-0.3	0.7	-0.4
Overall health rating	0.7	1.6	2.4	-1.6	1.1	-1.0
Chest pain or discomfort	0.7	1.0	1.7	1.0	0.5	-1.3
Had major operations	1.9	2.2	3.3	0.6	1.8	-1.7
Age at last live birth	0.5	0.8	1.6	-1.3	-0.1	0.8
Family relationship satisfaction	1.1	1.3	3.1	0.7	1.8	-0.6
Leg pain on walking	0.7	0.9	2.3	0.4	1.5	-0.6
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.1	5.9	-2.4	-0.6	1.7
Commuting to job workplace: Car/motor vehicle	2.1	2.5	5.6	2.4	0.2	-1.3
Illness, injury, bereavement, stress in last 2 years	2.5	3.0	6.8	-0.1	-1.5	2.6
Medication: Aspirin	0.1	0.1	0.2	0.5	0.1	-0.0
Supplements: Vitamin C	0.3	0.4	0.8	-0.6	0.0	0.9
Knee pain experienced in last month	4.2	6.5	17.1	-0.7	4.1	-1.4
Hypertension (Self-reported)	0.8	2.1	5.0	-0.0	-1.1	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.2	2.3	1.4	1.5	-1.5
Illnesses of father: Heart disease	1.7	2.4	4.5	2.1	0.7	-1.4
Illnesses of siblings: Diabetes	0.2	0.2	0.4	0.4	0.2	-0.6
Smoking status: Previous	0.7	1.0	1.4	0.6	-1.2	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.1	0.8	1.0	-0.3
Whole body fat-free mass	0.7	3.9	9.4	1.5	3.1	-0.1
Leg fat-free mass (right)	0.7	3.9	8.4	1.6	2.9	-1.0
Arm fat percentage (left)	1.3	5.3	8.9	0.9	3.0	-2.5
Average weekly red wine intake	3.2	4.8	6.0	-1.9	-2.4	2.2
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.9	-0.2	-0.9	-0.3
Mood swings	0.2	0.3	0.8	0.0	0.2	0.9
Loneliness, isolation	1.7	2.4	5.0	-1.2	2.2	-0.8
Long-standing illness, disability or infirmity	1.1	1.7	4.7	0.0	0.5	-2.2
Ever had bowel cancer screening	1.7	2.0	3.8	-2.0	-1.5	0.2
Diabetes diagnosed by doctor	0.3	0.4	0.6	-0.6	-0.6	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	3.1	1.8	-0.5	-1.6
Friendships satisfaction	0.1	0.2	0.3	-0.1	0.5	0.4
Qualifications: nursing, teaching	1.9	3.0	8.0	-0.9	-2.8	0.3
Commuting to job workplace: Walk	1.6	1.7	4.2	-0.9	0.3	2.0
Eye problems/disorders: Cataract	0.3	0.3	0.6	-0.7	-0.1	0.7
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	1.8	-0.7	-1.4	1.3
Medication for cholesterol	0.9	1.4	4.0	0.4	0.0	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.6	-0.7	-1.0	-1.6
Back pain experienced in last month	1.4	2.0	4.9	0.3	2.2	-1.0
Mineral and other dietary supplements	0.9	1.2	2.3	0.4	-1.5	-1.1
Breast cancer (self-reported)	0.3	0.3	0.9	0.1	0.9	0.1
Asthma (self-reported)	0.4	0.7	1.5	-1.2	-0.7	0.3
Osteoporosis (self-reported)	1.0	1.3	1.9	-0.1	-1.4	1.4
Osteoarthritis (self-reported)	1.1	1.4	2.8	0.8	0.8	-1.7
Medication: Aspirin	0.0	0.0	0.1	0.4	-0.0	-0.1
Medication: Gliclazide	0.6	0.6	1.0	-1.0	-1.0	0.1
Illnesses of father: None of the above (group 1)	4.0	4.9	8.2	-2.5	0.6	2.9
Smoking status: Current	1.2	2.0	4.7	0.2	2.2	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	4.3	1.4	-1.2	2.1
Whole body water mass	0.7	3.8	9.1	1.5	3.0	-0.1
Leg predicted mass (right)	0.7	3.9	8.4	1.6	2.9	-0.9
Arm fat mass (left)	1.4	5.7	11.6	1.1	3.4	-2.1
Number of self-reported non-cancer illnesses	0.7	1.2	3.3	0.2	0.4	-1.8
Average weekly champagne plus white wine intake	0.5	0.7	1.2	-1.1	-0.7	0.6
Miserableness	1.5	2.7	6.7	1.0	2.6	-0.6
Guilty feelings	0.4	0.6	1.1	-0.6	-0.4	1.1
Wears glasses or contact lenses	2.1	2.4	3.1	1.8	-1.6	-1.2
Ever taken oral contraceptive pill	0.0	0.1	0.1	0.2	0.3	0.1
Hearing aid user	0.1	0.1	0.1	0.3	0.0	-0.3
Mother’s age at death	0.2	0.2	0.5	0.7	-0.1	0.3
Financial situation satisfaction	0.9	1.2	3.5	0.1	1.9	-0.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.9	-0.1	0.7	-1.4
Commuting to job workplace: Public transport	0.2	0.3	0.7	-0.8	0.3	0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.3	0.4	-0.0
Medication: Blood pressure	0.4	0.8	2.0	-0.6	-0.1	-1.4
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.2	1.1	0.4	-1.0
Supplements: Fish oil (including cod liver oil)	1.5	2.0	5.8	-0.3	2.4	-0.4
High cholesterol (Self-reported)	0.8	1.4	3.6	-1.9	-0.7	-0.1
Medication: Bendroflumethiazide	0.7	1.0	1.3	1.2	-1.0	0.9
Medication: Paracetamol	0.9	1.4	2.6	0.1	1.6	-1.3
Medication: Lisinopril	0.1	0.1	0.3	-0.1	0.3	-0.6
Medication: Atorvastatin	0.9	1.1	2.1	1.4	-0.1	1.1
Illnesses of father: High blood pressure	1.6	2.0	4.2	1.3	-2.0	0.3
Alcohol drinker status: Never	1.7	2.0	2.7	1.6	1.5	-1.0
Ever smoked	0.3	0.5	1.3	1.1	0.2	0.3
Basal metabolic rate	0.7	3.8	8.9	1.5	3.0	-0.4
Leg fat percentage (left)	1.0	3.8	5.9	0.5	2.3	-2.4
Arm fat-free mass (left)	0.5	2.7	6.7	1.2	2.6	-0.4
Number of operations (self-reported)	0.4	0.6	0.7	0.8	0.8	-0.6
Average weekly beer plus cider intake	0.7	1.0	1.7	1.3	-0.3	-1.0
Irritability	0.6	1.0	2.5	0.6	1.6	0.3
Risk taking	1.3	1.9	2.9	1.3	1.7	1.1
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.8	0.9	-0.3	-0.6
Fractured/broken bones in last 5 years	1.0	1.3	3.0	0.2	0.9	1.7
Age started oral contraceptive pill	0.4	0.6	1.2	0.1	-0.7	1.1
Diastolic blood pressure, automated reading	0.4	1.3	2.4	0.6	-1.6	-1.0
Ever depressed for a whole week	0.2	0.3	0.6	0.1	0.8	0.4
Unable to work because of sickness or disability	0.4	0.5	1.1	-0.5	1.1	-0.2
Commuting to job workplace: Cycle	0.4	0.4	0.8	-0.7	-0.3	0.9
Myopia	0.8	1.1	2.7	0.7	0.4	-1.6
Vascular/heart problems diagnosed by doctor	0.7	1.8	4.2	-0.4	1.1	2.0
Cholesterol lowering medication	0.4	0.7	1.4	-0.3	-0.7	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	0.4	-0.7	-0.1
Pain experienced in last month	2.1	3.6	10.0	-0.7	-3.2	0.5
Supplements: Calcium	0.9	1.0	1.9	1.4	-0.9	0.5
Basal cell carcinoma (self-reported)	1.3	1.5	3.0	-1.7	-0.8	0.9
Heart attack/myocardial infarction (self-reported)	1.9	2.5	6.4	2.5	-0.9	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.1	1.4	0.4	-1.2
Heart disease (siblings)	0.8	0.9	1.5	-1.1	-0.2	-1.2
Alcohol drinker status: Previous	0.5	0.6	1.4	1.2	0.0	-0.6
Pack years of smoking	1.6	2.3	3.9	0.9	2.0	-1.5
Impedance of whole body	1.4	7.2	17.9	-1.9	-4.2	0.5
Leg fat mass (left)	1.4	5.6	9.9	1.0	3.1	-2.4
Arm predicted mass (left)	0.4	2.2	5.2	1.2	2.3	-0.3