Hub : Genes

RHOBTB1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.404 0.063 1.6e-10 0.115 0.129 0.150 0.15 0.145 7.9e-14 1.9e-15 8.5e-18 7.6e-18 2.9e-17
2 GTEx Testis 0.174 0.055 1.4e-04 0.091 NA 0.146 NA 0.158 7.4e-05 NA 5.0e-07 NA 1.7e-07
3 TCGA Stomach Adenocarcinoma 0.075 0.038 8.9e-03 -0.003 0.017 0.001 NA 0.001 6.5e-01 2.1e-02 2.8e-01 NA 2.7e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.6 1.0 1.6 0.1 -1.3 1.1
Bipolar Disorder or Schizophrenia 0.3 0.8 1.7 0.1 -0.8 1.3
Depressed Affect (Nagel 2018) 1.7 3.6 9.1 0.6 3.0 -1.2
Depression (Nagel 2018) 4.2 6.4 14.7 0.8 3.8 -2.0
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.4 1.6 -0.6 -0.0
Neuroticism (Nagel 2018) 0.3 0.7 1.8 -0.2 1.4 -0.5
Schizophrenia (2018) 0.1 0.2 0.5 0.0 0.0 0.7
Schizophrenia vs Biploar Disorder 1.9 2.4 5.4 -1.2 2.3 0.7
Worry (Nagel 2018) 0.2 0.5 1.0 -1.0 0.5 0.5
Alzheimer’s Disease (in mother) 2.1 2.5 3.5 -1.4 -1.4 1.9
Alzheimer’s Disease (in father) 0.9 1.0 1.5 1.2 1.1 -0.3
Alzheimer’s Disease (including proxy) 0.3 0.4 0.7 -0.6 -0.1 0.9
Crohns Disease (2017) 0.4 0.8 2.0 -0.5 -1.4 -0.3
Irritable Bowel Disease (IBD) 1.2 2.8 5.2 -1.2 -2.3 1.3
Ulcerative Colitis (UC) 1.6 2.9 4.7 -0.8 -2.2 1.8
Major Depression (MDD) 1.0 1.3 3.1 -0.0 1.8 -0.8
Reaction Time 0.2 0.4 1.2 -0.0 -0.2 -1.1
Verbal and Numeric Reasoning (VNR) 0.8 1.8 3.5 1.4 -1.9 -0.3
Breast Cancer 0.3 0.6 1.2 -1.1 0.1 0.9
Ovarian Cancer 1.0 1.3 3.8 0.2 -1.9 0.4
Prostate Cancer 1.2 1.6 3.5 1.9 -1.1 0.2
Age at First Birth 0.5 0.8 2.3 1.5 -0.2 -0.1
Bipolar Disorder (2011) 2.3 2.2 3.3 -0.6 -1.7 1.8
Body Mass Index (BMI) (2010) 3.3 4.5 8.2 0.5 2.9 -2.3
Coronary Artery Disease (CAD) 0.9 1.1 1.2 0.9 -1.1 -1.1
Crohns Disease (2012) 0.3 0.6 1.3 0.6 0.1 -1.1
Mean Putamen Volume 0.6 0.6 1.6 -0.3 1.2 -0.5
Fasting Glucose 0.2 0.2 0.5 -0.1 -0.7 -0.3
HbA1C 0.6 0.7 1.5 -1.2 -0.6 -0.6
HDL Cholesterol 1.1 1.8 2.4 -1.4 1.0 1.5
LDL Cholesterol 0.1 0.1 0.3 -0.2 0.5 -0.1
Lupus 1.2 1.9 5.0 2.2 0.7 0.4
Neuroticism (2016) 1.2 1.7 2.9 -1.7 -1.1 1.1
Primary Biliary Cirrhosis 0.2 0.2 0.3 0.5 -0.3 -0.6
Rheumatoid Arthritis 0.1 0.1 0.2 -0.4 -0.4 -0.2
Schizophrenia (2014) 0.1 0.3 0.7 0.3 0.1 0.9
Triglycerides 0.1 0.1 0.3 -0.0 -0.3 -0.5
Type 2 Diabetes (T2D) (2012) 1.0 1.1 2.5 -0.1 0.9 -1.6
Ulcerative Colitis 0.2 0.3 0.5 -0.4 -0.5 0.7
Blood Eosinophil Count 0.2 1.8 3.1 -1.5 -0.5 1.8
Blood Platelet Count 0.7 8.0 20.2 1.7 4.5 -0.9
Blood Red Count 0.0 0.0 0.0 -0.2 -0.2 -0.0
Blood White Count 0.3 2.5 4.5 2.1 1.7 -0.6
Heel T-Score 0.7 5.4 9.3 -0.1 -2.6 -3.0
BMI 1.4 8.0 17.2 1.3 4.2 -2.3
Height 0.3 6.5 10.8 -1.6 -3.3 2.5
Waist Hip Ratio (WHR) 0.3 1.2 2.5 -0.2 -1.0 1.6
Systolic Blood Pressure 1.9 9.3 27.9 -0.2 -5.3 0.3
Smoking Status 0.2 0.4 1.1 0.4 1.0 0.3
Allergy or Eczema 0.6 1.6 2.7 -1.5 -1.6 -0.2
Cardiovascular Disease 0.6 2.0 3.6 -1.0 -1.9 -1.1
Hypothyroidism (self reported) 0.4 1.0 1.5 -1.2 -1.2 0.2
Respiratory disease 0.3 0.6 1.0 -1.0 0.5 0.8
Type 2 Diabetes (T2D) (2018) 0.8 1.4 2.2 -0.8 -1.5 1.2
Lung FEV1/FVC ratio 0.6 2.9 8.5 -2.9 0.5 -0.3
Lung FVC 1.1 5.4 7.4 2.7 -1.6 2.5
Neuroticism 0.3 0.8 1.6 -0.8 1.3 0.3
Chronotype (morning person) 0.2 0.4 1.0 1.0 0.2 -0.1
Hair Pigment 0.0 0.1 0.4 0.0 0.2 0.6
Tanning 0.1 1.6 3.2 1.0 0.8 1.8
Hand grip strength (left) 0.1 0.3 0.6 0.8 -0.4 -0.2
Number of treatments/medications taken 1.0 1.8 4.2 -0.4 1.1 -2.0
Average weekly spirits intake 0.2 0.2 0.5 -0.5 -0.7 0.1
Sensitivity / hurt feelings 1.5 2.6 3.4 -1.8 -1.5 1.4
Frequency of depressed mood in last 2 weeks 2.9 4.1 12.1 -0.3 3.5 0.0
Hearing difficulty/problems: Yes 0.9 1.4 1.8 1.4 1.1 -1.1
Relative age of first facial hair 1.0 2.1 5.3 0.9 -0.1 -2.3
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.2 0.6 -1.1 -0.7
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.6 -0.1 0.8 -0.8
Ever had hysterectomy (womb removed) 1.4 1.6 3.2 0.3 1.2 -1.8
Systolic blood pressure, automated reading 1.2 3.6 10.7 -0.3 -3.3 -0.2
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 2.1 -0.0 -1.5 0.9
Angina 0.5 0.7 1.5 0.5 -1.2 -0.6
Medication for hormone replacement therapy 1.1 1.2 3.0 0.1 1.7 -0.8
Vitamin and mineral supplements 1.5 2.1 4.8 -1.2 -2.2 -0.2
Supplements: Zinc 0.2 0.2 0.6 0.8 0.0 -0.2
Medication: Co-codamol 0.2 0.2 0.3 -0.5 0.5 -0.1
Medication: Metformin 0.6 0.9 1.1 -0.9 -0.9 1.1
Diabetes (father) 0.3 0.3 0.6 0.5 -0.2 0.8
Diabetes (mother) 1.1 1.4 2.4 -0.1 1.5 1.3
Severe depression (siblings) 1.2 1.4 2.5 1.0 -0.8 -1.6
Pack years adult smoking proportion 1.3 1.9 3.6 0.9 1.9 -1.2
Impedance of leg (right) 1.4 6.8 15.3 -2.1 -3.9 0.8
Leg fat-free mass (left) 0.9 4.5 9.3 1.7 3.1 -1.2
Trunk fat percentage 1.0 3.9 7.7 0.2 2.0 -2.8
Hand grip strength (right) 0.1 0.3 0.6 0.7 0.8 0.2
Townsend deprivation index at recruitment 0.6 0.9 2.4 -0.3 1.6 -0.5
Current tobacco smoking 1.4 2.3 5.8 -0.2 2.4 -1.1
Average weekly fortified wine intake 1.0 1.2 2.2 -0.6 1.5 1.0
Maternal smoking around birth 1.6 2.3 6.0 0.4 2.5 -0.9
Fed-up feelings 1.5 2.7 7.4 0.4 2.7 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.8 2.4 4.6 1.4 2.1 -0.8
Relative age voice broke 0.8 1.3 2.0 0.7 -1.4 -1.2
Taking other prescription medications 0.9 1.5 2.4 1.1 0.8 -1.6
Age when periods started (menarche) 0.6 1.5 3.6 0.7 -1.9 0.6
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 1.9 -0.0 1.4 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 5.0 -2.2 0.2 -1.4
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.5 0.7 0.4 -0.3
Qualifications: CSEs or equivalent 1.0 1.3 2.3 -1.2 1.5 0.6
Serious illness, injury or assault to yourself 0.3 0.4 0.7 -0.8 -0.3 -0.7
High blood pressure 0.8 2.3 6.3 0.0 -0.9 -2.5
Hayfever, allergic rhinitis or eczema 0.5 1.1 1.7 -1.0 -1.3 -0.7
Multivitamins +/- minerals 4.0 5.0 10.8 2.0 3.3 -0.7
Stomach or abdominal pain in last month 0.2 0.3 0.7 -0.3 0.1 0.8
Supplements: Glucosamine 1.4 1.9 3.1 -1.4 0.8 1.8
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 2.0 0.2 1.4 -0.9
Medication: Atenolol 0.3 0.4 0.6 -0.6 -0.4 0.8
Medication: Levothyroxine sodium 0.3 0.5 0.6 -0.8 0.7 -0.5
Sitting height 0.0 0.0 0.0 0.1 -0.1 -0.1
Chronic bronchitis/emphysema (father) 2.1 2.5 6.7 -0.9 0.1 -2.6
High blood pressure (mother) 0.4 0.6 0.9 0.8 -0.9 -0.6
Body mass index (BMI) 1.8 7.7 16.2 1.4 4.0 -2.2
Impedance of leg (left) 1.6 7.7 17.5 -2.2 -4.2 1.0
Leg predicted mass (left) 0.8 4.4 9.2 1.6 3.0 -1.2
Trunk fat mass 1.0 4.2 6.2 0.6 2.5 -2.5
Waist circumference 1.0 3.6 6.2 1.2 2.5 -1.8
Number of incorrect matches in round 1.2 1.9 5.4 -2.3 0.1 0.6
Past tobacco smoking 0.4 0.8 1.6 -1.3 0.7 -0.6
Alcohol usually taken with meals 0.6 0.9 2.0 0.1 -0.9 1.4
Nervous feelings 0.2 0.3 0.7 -0.5 -0.8 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 3.7 -0.0 1.9 -0.8
Hearing difficulty/problems with background noise 1.1 1.8 3.7 1.9 0.9 1.0
Hair/balding pattern: Pattern 2 0.0 0.0 0.1 -0.1 -0.3 0.1
Had menopause 0.8 1.0 2.3 -1.5 -0.9 0.1
Had other major operations 0.2 0.2 0.4 0.4 -0.4 -0.7
Forced vital capacity (FVC) 1.0 3.8 7.8 1.5 -1.1 2.8
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.5 2.1 -1.3 -0.7 -1.4
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 1.0 -0.8 0.9 -1.0
Qualifications: None of the above 5.0 10.7 14.6 2.5 3.8 -3.4
Financial difficulties in last 2 years 2.1 2.9 4.9 -0.0 1.9 -2.2
Mouth/teeth dental problems 0.4 0.5 1.1 0.7 -1.0 0.2
Heart attack 1.9 2.4 6.6 2.6 -0.5 -0.6
Allergy 0.3 0.7 1.0 0.9 0.5 1.0
Pain all over the body in last month 0.9 0.9 2.4 -1.5 -0.5 -0.4
Diabetes (self-reported) 0.6 0.9 1.5 -1.2 -0.5 0.9
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 4.5 -0.5 -2.1 1.3
Medication: Ramipril 0.5 0.6 1.4 -0.4 0.5 -1.2
Medication: Simvastatin 0.9 1.3 1.8 -0.9 -1.1 -1.4
Fluid intelligence score 0.7 1.5 3.5 0.9 -1.9 0.3
Illnesses of siblings 0.5 0.7 2.1 -0.3 -0.0 1.5
Neuroticism score 0.4 0.8 1.3 -1.0 0.4 1.2
Weight 0.9 4.5 9.2 1.4 3.0 -1.5
Impedance of arm (right) 0.6 3.0 8.4 -0.7 -2.9 0.3
Arm fat percentage (right) 1.2 4.6 8.8 0.9 3.0 -2.1
Trunk fat-free mass 0.7 3.8 9.4 1.4 3.1 0.5
Hip circumference 0.7 3.0 4.4 0.9 2.0 -2.1
Time employed in main current job 0.9 1.1 1.6 -0.9 1.3 0.9
Alcohol intake versus 10 years previously 1.7 2.6 6.3 -1.2 2.5 0.0
Father’s age at death 0.6 0.9 2.0 -0.1 -1.4 0.8
Worrier / anxious feelings 2.8 5.2 11.4 -3.4 -1.5 1.4
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.7 4.7 -0.5 2.2 -0.5
Falls in the last year 2.3 3.1 7.2 -0.2 1.5 -2.7
Hair/balding pattern: Pattern 3 1.1 1.6 3.5 0.9 -1.9 -0.6
Number of live births 1.0 1.4 3.5 1.9 0.7 -0.6
Forced expiratory volume in 1-second (FEV1) 0.8 2.8 7.4 0.6 -0.8 2.7
Pulse rate 2.5 4.1 8.9 1.4 3.0 -1.3
Happiness 0.9 1.0 3.1 -0.1 1.7 -0.2
Noisy workplace 2.1 2.6 4.5 0.2 1.8 -2.1
Qualifications: A levels/AS levels or equivalent 2.1 4.6 13.2 0.3 -3.6 -0.8
Serious illness, injury or assault of a close relative in last 2 years 3.7 4.2 8.5 1.8 0.9 -2.9
Mouth/teeth dental problems: Dentures 5.7 9.6 18.9 2.6 4.3 -1.8
Asthma 0.2 0.4 1.2 -1.1 -0.2 0.3
Medication: Ibuprofen (e.g. Nurofen) 1.8 2.3 3.3 -1.8 1.7 -0.9
Medication: Cholesterol lowering 0.8 1.2 2.1 -1.2 -1.4 -0.2
Depression (self-reported) 0.9 1.0 2.1 -1.5 1.0 -0.2
Medication: Lansoprazole 0.5 0.5 0.6 0.8 -0.8 -0.6
Prospective memory result 2.6 3.2 6.0 0.8 2.5 -1.7
Lung cancer (father) 1.0 1.2 2.5 -1.6 -1.0 0.2
Illnesses of mother 0.8 1.0 3.0 0.2 1.7 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.4 6.3 0.8 -0.6 2.5
Pulse wave Arterial Stiffness index 0.8 0.9 1.6 1.1 -0.2 -1.3
Impedance of arm (left) 0.8 3.6 9.9 -1.0 -3.1 0.1
Arm fat mass (right) 1.2 5.1 10.1 1.2 3.2 -1.9
Trunk predicted mass 0.6 3.7 8.9 1.3 3.0 0.5
Standing height 0.1 1.0 1.7 -0.2 -1.3 1.1
Length of working week for main job 2.2 2.5 4.5 1.4 2.1 1.1
Exposure to tobacco smoke at home 2.2 2.5 7.0 0.2 2.7 -0.7
Breastfed as a baby 0.7 0.8 2.0 0.5 -0.5 -1.4
Tense / ‘highly strung’ 0.8 1.3 2.0 1.1 0.8 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.4 2.1 4.5 0.1 2.1 -1.3
Hair/balding pattern: Pattern 4 1.4 3.3 9.7 0.4 -3.1 -0.2
Birth weight of first child 0.5 0.9 2.5 0.1 -1.6 0.6
Peak expiratory flow (PEF) 0.6 1.3 2.6 0.8 -0.8 1.6
Pulse wave reflection index 0.6 0.8 0.9 0.9 -0.8 -0.9
Ever highly irritable/argumentative for 2 days 1.9 2.3 4.9 0.9 2.2 -1.1
Loud music exposure frequency 0.5 0.6 1.7 0.2 -0.1 1.3
Qualifications: O levels/GCSEs or equivalent 2.6 4.1 9.9 -0.4 -3.1 1.5
Mouth/teeth dental problems: Bleeding gums 2.7 3.6 5.7 -2.4 -2.1 0.9
Blood clot in the leg (DVT) 0.8 1.0 1.6 1.2 0.3 -1.3
Medication: Paracetamol 0.6 0.9 2.1 -0.3 1.4 -0.8
Headache pain in last month 1.8 3.1 8.4 0.9 2.9 0.0
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.5 0.1 1.2 0.5
Glaucoma (self-reported) 0.3 0.3 0.6 -0.6 0.1 -0.8
Gout (self-reported) 0.4 0.5 0.8 0.3 0.8 -0.9
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.3 -0.6 0.1 0.1
Medication: Amlodipine 0.9 1.3 2.7 1.6 -0.6 -1.0
Medication: Ventolin 100micrograms inhaler 0.8 1.1 1.7 1.2 0.2 -1.3
Birth weight 0.3 0.6 1.7 0.1 0.5 1.3
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.0 0.2 1.4 -0.7
High blood pressure (siblings) 0.3 0.4 1.3 1.1 0.0 -0.2
Forced vital capacity (FVC), Best measure 0.8 3.0 6.2 1.6 -0.6 2.5
Body fat percentage 1.1 4.3 7.3 0.6 2.3 -2.7
Leg fat percentage (right) 1.1 4.1 6.2 0.5 2.4 -2.5
Arm fat-free mass (right) 0.4 2.1 4.7 1.2 2.2 -0.7
Exposure to tobacco smoke outside home 2.6 3.4 4.6 1.2 2.1 -2.0
Comparative body size at age 10 1.4 3.8 8.4 0.8 2.9 -1.5
Number of full brothers 1.8 2.3 3.0 1.1 1.7 -1.7
Worry too long after embarrassment 1.1 1.8 2.4 -1.2 -1.5 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 2.4 -0.7 1.5 -1.2
Wheeze or whistling in the chest in last year 0.8 1.5 3.3 -0.0 1.1 -1.8
Number of children fathered 0.1 0.1 0.2 -0.3 -0.5 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.1 0.1 -0.9 1.0
Age at first live birth 0.3 0.6 1.0 -0.9 -1.0 -0.1
Pulse wave peak to peak time 0.8 1.0 1.8 -1.0 -0.1 1.4
Health satisfaction 1.6 2.0 4.9 0.5 2.2 -0.9
Shortness of breath walking on level ground 2.7 3.2 4.4 1.8 1.4 -2.1
Qualifications: College or University degree 0.6 1.8 4.5 -0.4 -2.1 0.9
Eye problems/disorders: None of the above 0.1 0.1 0.1 0.3 -0.1 -0.3
Mouth/teeth dental problems: Loose teeth 0.4 0.5 0.9 -0.3 -0.7 -0.9
Emphysema/chronic bronchitis 1.2 1.4 2.7 -1.6 0.1 1.2
Medication for pain relief, constipation, heartburn 0.3 0.6 0.8 0.7 -0.7 0.9
Neck or shoulder pain in last month 2.1 2.9 6.6 1.4 2.6 -0.5
Medication: Blood pressure 0.6 1.0 1.6 1.3 -1.1 -0.5
Angina (self-reported) 0.5 0.7 1.1 0.6 -1.0 -0.7
Migraine (self-reported) 1.0 1.3 3.2 0.8 1.8 0.1
Medication: Ibuprofen 0.8 1.0 1.9 -1.4 1.0 -0.3
Medication: Allopurinol 0.8 1.1 1.7 1.3 0.8 -0.9
Medication: Omeprazole 0.4 0.4 1.2 -0.1 -1.1 -0.3
Medication: Seretide 50 evohaler 1.0 1.2 1.9 -1.4 -0.5 -1.2
Mean time to correctly identify matches 0.5 1.0 3.1 -0.1 -0.1 -1.8
Heart disease (mother) 0.4 0.5 0.6 -0.6 -0.7 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.6 -0.7 1.3 -0.1
Whole body fat mass 1.1 4.6 7.2 0.8 2.7 -2.5
Leg fat mass (right) 1.5 5.8 10.5 1.0 3.2 -2.4
Arm predicted mass (right) 0.4 2.1 5.3 1.0 2.3 -0.3
Pulse rate, automated reading 1.2 4.0 7.6 2.1 2.7 -0.1
Alcohol intake frequency. 2.9 6.6 16.1 1.1 4.0 -1.6
Comparative height size at age 10 0.4 2.4 3.6 -1.7 0.9 1.9
Number of full sisters 0.7 0.9 1.9 1.4 0.7 -0.5
Suffer from ‘nerves’ 0.1 0.2 0.4 -0.3 0.7 -0.4
Overall health rating 0.7 1.6 2.4 -1.6 1.1 -1.0
Chest pain or discomfort 0.7 1.0 1.7 1.0 0.5 -1.3
Had major operations 1.9 2.2 3.3 0.6 1.8 -1.7
Age at last live birth 0.5 0.8 1.6 -1.3 -0.1 0.8
Family relationship satisfaction 1.1 1.3 3.1 0.7 1.8 -0.6
Leg pain on walking 0.7 0.9 2.3 0.4 1.5 -0.6
Qualifications: NVQ or HND or HNC or equivalent 2.5 3.1 5.9 -2.4 -0.6 1.7
Commuting to job workplace: Car/motor vehicle 2.1 2.5 5.6 2.4 0.2 -1.3
Illness, injury, bereavement, stress in last 2 years 2.5 3.0 6.8 -0.1 -1.5 2.6
Medication: Aspirin 0.1 0.1 0.2 0.5 0.1 -0.0
Supplements: Vitamin C 0.3 0.4 0.8 -0.6 0.0 0.9
Knee pain experienced in last month 4.2 6.5 17.1 -0.7 4.1 -1.4
Hypertension (Self-reported) 0.8 2.1 5.0 -0.0 -1.1 -2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.8 2.2 2.3 1.4 1.5 -1.5
Illnesses of father: Heart disease 1.7 2.4 4.5 2.1 0.7 -1.4
Illnesses of siblings: Diabetes 0.2 0.2 0.4 0.4 0.2 -0.6
Smoking status: Previous 0.7 1.0 1.4 0.6 -1.2 1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.1 0.8 1.0 -0.3
Whole body fat-free mass 0.7 3.9 9.4 1.5 3.1 -0.1
Leg fat-free mass (right) 0.7 3.9 8.4 1.6 2.9 -1.0
Arm fat percentage (left) 1.3 5.3 8.9 0.9 3.0 -2.5
Average weekly red wine intake 3.2 4.8 6.0 -1.9 -2.4 2.2
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.9 -0.2 -0.9 -0.3
Mood swings 0.2 0.3 0.8 0.0 0.2 0.9
Loneliness, isolation 1.7 2.4 5.0 -1.2 2.2 -0.8
Long-standing illness, disability or infirmity 1.1 1.7 4.7 0.0 0.5 -2.2
Ever had bowel cancer screening 1.7 2.0 3.8 -2.0 -1.5 0.2
Diabetes diagnosed by doctor 0.3 0.4 0.6 -0.6 -0.6 0.8
Ever had stillbirth, spontaneous miscarriage or termination 1.8 1.9 3.1 1.8 -0.5 -1.6
Friendships satisfaction 0.1 0.2 0.3 -0.1 0.5 0.4
Qualifications: nursing, teaching 1.9 3.0 8.0 -0.9 -2.8 0.3
Commuting to job workplace: Walk 1.6 1.7 4.2 -0.9 0.3 2.0
Eye problems/disorders: Cataract 0.3 0.3 0.6 -0.7 -0.1 0.7
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 1.8 -0.7 -1.4 1.3
Medication for cholesterol 0.9 1.4 4.0 0.4 0.0 2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 2.6 -0.7 -1.0 -1.6
Back pain experienced in last month 1.4 2.0 4.9 0.3 2.2 -1.0
Mineral and other dietary supplements 0.9 1.2 2.3 0.4 -1.5 -1.1
Breast cancer (self-reported) 0.3 0.3 0.9 0.1 0.9 0.1
Asthma (self-reported) 0.4 0.7 1.5 -1.2 -0.7 0.3
Osteoporosis (self-reported) 1.0 1.3 1.9 -0.1 -1.4 1.4
Osteoarthritis (self-reported) 1.1 1.4 2.8 0.8 0.8 -1.7
Medication: Aspirin 0.0 0.0 0.1 0.4 -0.0 -0.1
Medication: Gliclazide 0.6 0.6 1.0 -1.0 -1.0 0.1
Illnesses of father: None of the above (group 1) 4.0 4.9 8.2 -2.5 0.6 2.9
Smoking status: Current 1.2 2.0 4.7 0.2 2.2 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.6 4.3 1.4 -1.2 2.1
Whole body water mass 0.7 3.8 9.1 1.5 3.0 -0.1
Leg predicted mass (right) 0.7 3.9 8.4 1.6 2.9 -0.9
Arm fat mass (left) 1.4 5.7 11.6 1.1 3.4 -2.1
Number of self-reported non-cancer illnesses 0.7 1.2 3.3 0.2 0.4 -1.8
Average weekly champagne plus white wine intake 0.5 0.7 1.2 -1.1 -0.7 0.6
Miserableness 1.5 2.7 6.7 1.0 2.6 -0.6
Guilty feelings 0.4 0.6 1.1 -0.6 -0.4 1.1
Wears glasses or contact lenses 2.1 2.4 3.1 1.8 -1.6 -1.2
Ever taken oral contraceptive pill 0.0 0.1 0.1 0.2 0.3 0.1
Hearing aid user 0.1 0.1 0.1 0.3 0.0 -0.3
Mother’s age at death 0.2 0.2 0.5 0.7 -0.1 0.3
Financial situation satisfaction 0.9 1.2 3.5 0.1 1.9 -0.1
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.9 -0.1 0.7 -1.4
Commuting to job workplace: Public transport 0.2 0.3 0.7 -0.8 0.3 0.2
Eye problems/disorders: Glaucoma 0.1 0.1 0.2 -0.3 0.4 -0.0
Medication: Blood pressure 0.4 0.8 2.0 -0.6 -0.1 -1.4
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.2 1.1 0.4 -1.0
Supplements: Fish oil (including cod liver oil) 1.5 2.0 5.8 -0.3 2.4 -0.4
High cholesterol (Self-reported) 0.8 1.4 3.6 -1.9 -0.7 -0.1
Medication: Bendroflumethiazide 0.7 1.0 1.3 1.2 -1.0 0.9
Medication: Paracetamol 0.9 1.4 2.6 0.1 1.6 -1.3
Medication: Lisinopril 0.1 0.1 0.3 -0.1 0.3 -0.6
Medication: Atorvastatin 0.9 1.1 2.1 1.4 -0.1 1.1
Illnesses of father: High blood pressure 1.6 2.0 4.2 1.3 -2.0 0.3
Alcohol drinker status: Never 1.7 2.0 2.7 1.6 1.5 -1.0
Ever smoked 0.3 0.5 1.3 1.1 0.2 0.3
Basal metabolic rate 0.7 3.8 8.9 1.5 3.0 -0.4
Leg fat percentage (left) 1.0 3.8 5.9 0.5 2.3 -2.4
Arm fat-free mass (left) 0.5 2.7 6.7 1.2 2.6 -0.4
Number of operations (self-reported) 0.4 0.6 0.7 0.8 0.8 -0.6
Average weekly beer plus cider intake 0.7 1.0 1.7 1.3 -0.3 -1.0
Irritability 0.6 1.0 2.5 0.6 1.6 0.3
Risk taking 1.3 1.9 2.9 1.3 1.7 1.1
Ever had prostate specific antigen (PSA) test 0.4 0.4 0.8 0.9 -0.3 -0.6
Fractured/broken bones in last 5 years 1.0 1.3 3.0 0.2 0.9 1.7
Age started oral contraceptive pill 0.4 0.6 1.2 0.1 -0.7 1.1
Diastolic blood pressure, automated reading 0.4 1.3 2.4 0.6 -1.6 -1.0
Ever depressed for a whole week 0.2 0.3 0.6 0.1 0.8 0.4
Unable to work because of sickness or disability 0.4 0.5 1.1 -0.5 1.1 -0.2
Commuting to job workplace: Cycle 0.4 0.4 0.8 -0.7 -0.3 0.9
Myopia 0.8 1.1 2.7 0.7 0.4 -1.6
Vascular/heart problems diagnosed by doctor 0.7 1.8 4.2 -0.4 1.1 2.0
Cholesterol lowering medication 0.4 0.7 1.4 -0.3 -0.7 -1.2
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.5 0.4 -0.7 -0.1
Pain experienced in last month 2.1 3.6 10.0 -0.7 -3.2 0.5
Supplements: Calcium 0.9 1.0 1.9 1.4 -0.9 0.5
Basal cell carcinoma (self-reported) 1.3 1.5 3.0 -1.7 -0.8 0.9
Heart attack/myocardial infarction (self-reported) 1.9 2.5 6.4 2.5 -0.9 -0.5
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 2.1 1.4 0.4 -1.2
Heart disease (siblings) 0.8 0.9 1.5 -1.1 -0.2 -1.2
Alcohol drinker status: Previous 0.5 0.6 1.4 1.2 0.0 -0.6
Pack years of smoking 1.6 2.3 3.9 0.9 2.0 -1.5
Impedance of whole body 1.4 7.2 17.9 -1.9 -4.2 0.5
Leg fat mass (left) 1.4 5.6 9.9 1.0 3.1 -2.4
Arm predicted mass (left) 0.4 2.2 5.2 1.2 2.3 -0.3