Hub : Genes

MRPL23

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Skin Sun Exposed Lower leg 0.0930 0.0360 3.1e-03 0.004 NA -0.003 NA -0.003 1.3e-01 NA 7.2e-01 NA 6.5e-01
2 ROSMAP Brain Pre-frontal Cortex 0.1484 0.0340 2.4e-09 0.111 0.090 0.110 0.109 0.108 3.8e-14 1.4e-11 5.9e-14 7.2e-14 1.0e-13
3 YFS Blood 0.2237 0.0326 0.0e+00 0.037 0.089 0.103 0.089 0.071 3.6e-12 1.9e-27 6.9e-32 1.0e-27 4.2e-22
4 TCGA Brain Lower Grade Glioma 0.0379 0.0199 4.7e-05 0.062 0.044 0.036 NA 0.055 1.4e-07 9.2e-06 6.0e-05 NA 7.5e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.7 1.1 3.4 0.6 -0.4 1.8 -0.5
Bipolar Disorder or Schizophrenia 0.2 0.5 0.9 -0.6 0.1 0.9 0.8
Depressed Affect (Nagel 2018) 0.3 0.6 1.0 0.8 -0.8 -0.3 -1.0
Depression (Nagel 2018) 1.3 2.0 4.0 1.5 -1.1 0.7 -2.0
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.1 0.7 -0.5 -1.0 -1.0
Neuroticism (Nagel 2018) 0.7 1.7 2.8 1.5 -1.3 0.1 -1.7
Schizophrenia (2018) 0.5 0.9 1.8 -1.3 0.5 -0.4 1.3
Schizophrenia vs Biploar Disorder 1.5 2.0 5.9 -1.1 -0.2 -2.4 0.9
Worry (Nagel 2018) 0.5 1.1 1.7 1.2 -1.2 0.0 -1.3
Alzheimer’s Disease (in mother) 1.0 1.2 4.5 -0.4 -0.3 -2.1 0.4
Alzheimer’s Disease (in father) 0.4 0.4 0.8 -0.6 0.5 -0.4 0.9
Alzheimer’s Disease (including proxy) 1.0 1.4 4.2 -0.7 0.2 -2.1 0.9
Crohns Disease (2017) 0.3 0.6 1.4 1.2 -0.4 -0.2 -1.0
Irritable Bowel Disease (IBD) 0.7 1.7 3.5 1.9 -0.7 -0.5 -1.6
Ulcerative Colitis (UC) 0.3 0.5 1.2 1.1 0.3 -0.3 -0.9
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.2 0.4 1.3 0.1 0.4 -1.1 -0.1
Verbal and Numeric Reasoning (VNR) 0.5 1.1 4.1 -0.4 0.3 -2.0 0.4
Breast Cancer 9.7 23.4 37.8 5.6 -4.9 -0.5 -6.2
Ovarian Cancer 0.8 1.0 3.7 -0.4 0.3 1.9 0.1
Prostate Cancer 0.7 1.0 3.4 0.4 -0.4 1.8 -0.6
Age at First Birth 0.7 1.1 1.8 1.3 -0.4 -1.0 -1.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 2.7 -0.0 0.1 -1.6 0.3
Coronary Artery Disease (CAD) 2.3 2.8 8.2 2.9 -1.6 0.6 0.0
Crohns Disease (2012) 0.3 0.5 1.3 0.5 1.1 -0.5 -0.1
Mean Putamen Volume 3.5 4.0 5.4 2.1 -1.9 1.7 -2.3
Fasting Glucose 1.2 1.4 2.0 1.3 -0.4 1.4 -1.4
HbA1C 0.6 0.7 1.5 0.8 -0.3 1.2 -0.7
HDL Cholesterol 0.2 0.3 0.4 0.6 -0.4 -0.5 -0.6
LDL Cholesterol 0.4 0.6 2.4 -0.3 0.3 -1.5 0.2
Lupus 0.8 1.2 2.2 -0.4 1.5 1.5 0.6
Neuroticism (2016) 0.3 0.4 0.7 -0.5 -0.7 0.8 0.6
Primary Biliary Cirrhosis 1.7 2.4 5.1 1.3 -2.3 0.2 -1.7
Rheumatoid Arthritis 0.4 0.6 1.1 0.3 1.0 -1.0 0.1
Schizophrenia (2014) 0.1 0.1 0.3 -0.4 -0.3 -0.1 0.5
Triglycerides 0.7 1.2 4.2 -0.5 0.5 -2.0 0.5
Type 2 Diabetes (T2D) (2012) 1.8 2.1 3.8 1.9 -1.3 -0.0 -1.7
Ulcerative Colitis 0.3 0.4 0.8 0.9 -0.2 0.5 -0.7
Blood Eosinophil Count 0.1 0.9 1.4 -1.1 0.8 -0.7 1.2
Blood Platelet Count 0.8 8.9 12.7 -3.3 3.6 -0.9 3.3
Blood Red Count 0.5 4.8 8.1 -1.9 2.8 0.9 2.6
Blood White Count 0.3 2.0 5.2 -0.9 2.3 0.1 1.4
Heel T-Score 0.0 0.3 0.7 0.5 0.3 -0.8 -0.3
BMI 0.4 2.2 3.5 -1.3 1.7 0.8 1.9
Height 0.6 10.8 16.6 4.1 -3.9 0.2 -3.4
Waist Hip Ratio (WHR) 0.3 1.4 2.1 -1.4 0.8 0.9 1.4
Systolic Blood Pressure 4.5 22.5 37.9 5.5 -4.7 0.6 -6.2
Smoking Status 0.5 1.1 3.2 -0.7 0.6 1.8 0.4
Allergy or Eczema 0.6 1.5 2.9 -0.7 1.2 -1.7 1.0
Cardiovascular Disease 1.9 6.2 8.6 2.8 -2.5 1.3 -2.9
Hypothyroidism (self reported) 0.7 1.7 2.2 1.2 -1.5 -1.4 -1.1
Respiratory disease 4.6 10.2 15.8 -4.0 3.4 0.2 3.6
Type 2 Diabetes (T2D) (2018) 0.8 1.5 3.4 1.4 -0.1 1.8 -0.9
Lung FEV1/FVC ratio 0.7 3.6 8.9 -1.8 -0.2 -3.0 1.4
Lung FVC 0.0 0.2 0.8 -0.1 0.2 0.9 0.3
Neuroticism 0.6 1.4 1.8 1.1 -1.0 1.1 -1.3
Chronotype (morning person) 0.4 1.0 2.1 -0.9 -0.3 -1.4 0.9
Hair Pigment 0.1 2.8 11.1 -0.1 0.1 -3.3 -0.1
Tanning 0.3 3.4 4.1 -1.6 1.9 2.0 1.7
Hand grip strength (left) 0.5 1.4 2.0 1.0 -1.4 -1.2 -1.0
Number of treatments/medications taken 0.5 1.0 2.3 -0.9 0.6 1.5 0.7
Average weekly spirits intake 0.3 0.3 0.7 -0.2 0.8 0.7 0.1
Sensitivity / hurt feelings 0.2 0.4 0.9 -0.2 1.0 0.6 0.4
Frequency of depressed mood in last 2 weeks 0.7 1.0 1.8 1.2 -0.8 0.5 -1.4
Hearing difficulty/problems: Yes 0.3 0.4 1.2 0.5 0.1 -1.1 -0.5
Relative age of first facial hair 1.1 2.2 2.9 1.3 -1.3 -1.7 -1.6
Other serious medical condition/disability diagnosed by doctor 2.1 2.7 3.7 1.9 -1.7 -0.9 -1.9
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.7 0.6 -0.1 1.3 -0.7
Ever had hysterectomy (womb removed) 0.3 0.4 0.7 -0.4 -0.8 0.8 -0.3
Systolic blood pressure, automated reading 1.0 2.8 5.8 1.7 -1.4 0.8 -2.4
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 2.3 -1.5 0.1 -1.0 1.4
Angina 0.2 0.3 0.5 -0.7 0.1 -0.6 0.6
Medication for hormone replacement therapy 0.1 0.1 0.3 -0.2 -0.3 0.5 -0.2
Vitamin and mineral supplements 0.0 0.0 0.1 -0.0 -0.2 0.3 0.1
Supplements: Zinc 2.3 2.5 4.5 2.1 -1.6 0.2 -1.7
Medication: Co-codamol 1.3 1.5 2.0 -1.2 1.0 -1.4 1.2
Medication: Metformin 0.4 0.6 1.1 0.8 -0.6 1.0 -0.5
Diabetes (father) 0.1 0.1 0.4 0.6 0.2 0.0 -0.3
Diabetes (mother) 0.5 0.6 1.0 -0.5 1.0 0.9 0.6
Severe depression (siblings) 0.6 0.6 1.1 0.9 -1.0 0.2 -0.8
Pack years adult smoking proportion 0.1 0.1 0.5 0.1 0.2 -0.7 -0.1
Impedance of leg (right) 0.9 4.1 8.5 0.8 -2.2 -2.9 -1.6
Leg fat-free mass (left) 0.1 0.3 0.7 0.5 0.6 0.8 0.2
Trunk fat percentage 1.7 6.7 9.5 -3.0 2.8 0.6 3.1
Hand grip strength (right) 0.3 0.9 1.4 0.7 -1.2 -1.1 -0.7
Townsend deprivation index at recruitment 0.6 0.8 2.4 0.4 -0.7 1.5 -0.2
Current tobacco smoking 1.1 1.8 2.8 1.6 -1.1 0.8 -1.7
Average weekly fortified wine intake 0.0 0.1 0.1 -0.3 -0.3 0.0 0.2
Maternal smoking around birth 0.2 0.3 0.6 -0.8 0.3 0.4 0.7
Fed-up feelings 1.1 2.0 2.9 1.7 -1.4 0.6 -1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 1.1 1.0 -0.6 0.4 -1.0
Relative age voice broke 0.4 0.7 2.2 0.4 0.4 -1.5 -0.4
Taking other prescription medications 0.2 0.3 0.7 -0.4 0.3 0.8 0.4
Age when periods started (menarche) 2.4 5.7 9.9 -3.0 1.9 0.5 3.1
Bilateral oophorectomy (both ovaries removed) 0.1 0.2 0.5 -0.3 -0.7 -0.2 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 2.0 -0.9 0.7 0.1 1.4
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.7 0.4 -0.2 -0.8 -0.7
Qualifications: CSEs or equivalent 0.3 0.4 0.8 0.6 -0.9 -0.2 -0.8
Serious illness, injury or assault to yourself 0.4 0.5 0.9 0.6 0.8 0.9 -0.3
High blood pressure 3.8 10.7 13.8 3.6 -3.7 1.5 -3.7
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.1 -0.3 0.9 -1.0 0.5
Multivitamins +/- minerals 0.3 0.4 0.6 -0.8 0.6 -0.5 0.5
Stomach or abdominal pain in last month 0.7 0.9 1.2 -1.0 0.5 1.1 1.0
Supplements: Glucosamine 0.1 0.1 0.4 -0.6 -0.4 -0.1 0.2
Diverticular disease/diverticulitis (self-reported) 3.2 3.8 5.8 -1.5 2.4 2.1 1.7
Medication: Atenolol 3.3 4.1 6.3 2.4 -2.1 0.3 -2.5
Medication: Levothyroxine sodium 1.2 2.0 3.5 1.4 -1.9 -0.9 -1.2
Sitting height 1.1 8.0 13.0 3.6 -2.2 -2.5 -2.9
Chronic bronchitis/emphysema (father) 1.8 2.1 3.8 -1.4 1.9 0.8 1.4
High blood pressure (mother) 3.9 5.5 8.4 2.6 -1.2 -2.9 -2.4
Body mass index (BMI) 0.8 3.2 4.5 -1.9 2.0 0.9 2.1
Impedance of leg (left) 0.7 3.3 10.4 0.1 -1.4 -3.2 -0.9
Leg predicted mass (left) 0.1 0.3 0.7 0.5 0.4 0.9 0.2
Trunk fat mass 0.8 3.2 4.9 -1.9 2.1 0.4 2.2
Waist circumference 0.8 2.9 4.8 -1.8 1.8 0.5 2.2
Number of incorrect matches in round 4.8 8.0 11.6 3.4 -3.3 0.1 -3.1
Past tobacco smoking 1.4 2.6 7.6 1.0 -0.8 -2.8 -0.9
Alcohol usually taken with meals 0.2 0.4 0.7 -0.6 0.9 -0.6 0.3
Nervous feelings 2.0 3.7 5.9 2.0 -2.4 -1.1 -1.9
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.8 2.0 1.4 -1.1 1.4 -1.4
Hearing difficulty/problems with background noise 1.1 1.8 2.4 1.6 -1.2 -1.1 -1.5
Hair/balding pattern: Pattern 2 0.4 0.4 1.5 0.5 0.2 1.2 -0.1
Had menopause 1.8 2.2 5.1 -1.1 0.9 2.3 1.2
Had other major operations 0.6 0.8 1.6 -0.6 1.3 1.0 0.5
Forced vital capacity (FVC) 0.2 0.9 1.7 1.3 -0.3 -0.9 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 1.4 -0.7 0.6 -0.9 1.2
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 0.9 -0.6 0.7 1.0 0.7
Qualifications: None of the above 0.5 1.1 2.9 -0.9 -0.0 1.7 0.9
Financial difficulties in last 2 years 0.2 0.3 1.2 -0.1 0.4 1.1 0.2
Mouth/teeth dental problems 0.3 0.4 1.1 -0.4 1.0 -0.5 0.3
Heart attack 0.3 0.4 1.2 -0.1 0.6 -1.1 0.2
Allergy 1.7 3.9 4.8 2.1 -2.2 1.3 -2.2
Pain all over the body in last month 0.5 0.6 1.9 -0.1 -0.5 1.4 -0.3
Diabetes (self-reported) 0.6 0.9 1.5 1.2 -0.7 0.8 -0.8
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 3.8 0.3 -0.6 -1.9 -0.1
Medication: Ramipril 2.9 3.7 5.1 2.0 -2.1 1.1 -2.2
Medication: Simvastatin 0.4 0.5 1.3 1.1 0.2 0.6 -0.6
Fluid intelligence score 0.8 1.6 3.7 1.0 -0.8 -1.9 -1.0
Illnesses of siblings 0.2 0.2 0.8 0.0 0.5 0.9 -0.1
Neuroticism score 0.9 1.9 2.3 1.5 -1.4 1.0 -1.5
Weight 0.1 0.3 0.6 -0.1 0.7 0.6 0.6
Impedance of arm (right) 0.4 2.0 3.9 -2.0 1.2 -0.4 1.6
Arm fat percentage (right) 1.9 7.6 10.4 -3.2 2.9 1.2 3.2
Trunk fat-free mass 0.9 5.2 9.8 3.1 -2.2 -0.5 -2.4
Hip circumference 0.1 0.6 1.0 -0.5 0.9 -0.5 1.0
Time employed in main current job 0.1 0.1 0.3 -0.2 -0.3 0.5 -0.1
Alcohol intake versus 10 years previously 1.0 1.5 3.5 1.1 -1.9 -0.6 -1.0
Father’s age at death 0.8 1.1 1.4 -1.2 1.1 -0.6 1.2
Worrier / anxious feelings 0.1 0.3 0.5 0.7 0.1 0.6 -0.5
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 2.1 1.2 -1.5 1.4 -1.3
Falls in the last year 2.8 3.8 5.9 2.4 -1.7 0.9 -2.4
Hair/balding pattern: Pattern 3 0.1 0.2 0.5 -0.3 0.7 -0.4 0.2
Number of live births 0.8 1.1 3.1 -0.7 0.7 1.8 0.7
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 5.8 0.6 -0.0 -2.4 -0.3
Pulse rate 0.5 0.8 1.3 -0.6 1.1 -0.9 0.9
Happiness 3.9 4.8 7.4 2.7 -2.2 -0.1 -2.7
Noisy workplace 0.2 0.3 0.4 0.5 0.4 0.4 -0.7
Qualifications: A levels/AS levels or equivalent 1.0 2.3 3.9 2.0 -1.1 -1.2 -1.6
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.8 -0.7 0.3 0.9 0.3
Mouth/teeth dental problems: Dentures 0.4 0.6 2.4 -0.1 0.3 1.6 0.2
Asthma 2.8 5.5 9.2 -3.0 2.2 -0.4 2.8
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 0.2 -0.5 0.3 -0.2
Medication: Cholesterol lowering 0.8 1.2 2.6 1.6 -0.0 0.4 -1.4
Depression (self-reported) 1.2 1.4 2.8 1.0 -1.0 1.7 -0.9
Medication: Lansoprazole 1.0 1.1 1.8 -0.9 1.3 1.0 1.0
Prospective memory result 0.9 1.1 2.4 -0.6 0.8 1.6 1.0
Lung cancer (father) 0.3 0.4 0.5 0.5 -0.7 -0.5 -0.7
Illnesses of mother 2.5 3.0 4.1 -2.0 1.3 1.9 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 3.4 0.0 0.6 -1.9 0.4
Pulse wave Arterial Stiffness index 0.2 0.3 0.4 -0.3 0.6 -0.5 0.7
Impedance of arm (left) 0.6 2.8 5.0 -2.2 1.6 -0.2 1.9
Arm fat mass (right) 0.9 3.8 5.3 -2.1 2.2 0.8 2.3
Trunk predicted mass 1.0 5.6 10.5 3.2 -2.3 -0.4 -2.5
Standing height 0.8 8.0 13.4 3.7 -2.8 -0.9 -3.2
Length of working week for main job 0.4 0.5 1.5 -0.4 1.2 -0.5 0.3
Exposure to tobacco smoke at home 0.7 0.8 2.7 0.4 -0.4 1.6 -0.5
Breastfed as a baby 0.1 0.1 0.2 0.3 -0.5 0.3 -0.0
Tense / ‘highly strung’ 0.3 0.5 0.6 0.6 -0.8 0.8 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.7 2.5 3.8 1.9 -1.4 1.2 -1.7
Hair/balding pattern: Pattern 4 0.1 0.3 0.8 -0.3 -0.7 0.9 -0.1
Birth weight of first child 1.7 3.1 8.0 1.3 -0.9 2.8 -1.3
Peak expiratory flow (PEF) 1.1 2.5 3.5 -1.4 1.2 -1.9 1.8
Pulse wave reflection index 0.0 0.0 0.1 -0.2 -0.2 -0.3 0.2
Ever highly irritable/argumentative for 2 days 0.8 1.0 1.9 1.4 -0.5 0.1 -1.3
Loud music exposure frequency 1.2 1.3 2.1 1.1 -1.4 0.2 -1.3
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.1 0.3 1.0 -1.5 0.0
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 1.4 1.1 -1.2 -0.6 -1.0
Blood clot in the leg (DVT) 0.3 0.4 0.7 -0.9 0.8 0.3 0.4
Medication: Paracetamol 0.1 0.2 0.3 0.1 -0.6 0.5 -0.2
Headache pain in last month 0.1 0.2 0.2 -0.5 0.3 0.4 0.4
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 2.4 -1.6 0.3 -0.7 1.5
Glaucoma (self-reported) 0.5 0.6 0.8 -0.7 0.9 0.8 0.7
Gout (self-reported) 0.3 0.5 0.7 -0.5 0.9 0.7 0.7
Hypothyroidism/myxoedema (self-reported) 1.1 2.1 4.1 1.2 -2.0 -1.3 -1.1
Medication: Amlodipine 1.9 2.6 5.0 1.6 -1.5 0.9 -2.2
Medication: Ventolin 100micrograms inhaler 1.6 2.1 3.2 -1.8 1.5 0.2 1.7
Birth weight 0.6 1.4 4.3 0.8 0.2 2.1 -0.7
Chronic bronchitis/emphysema (mother) 0.4 0.4 0.8 -0.5 0.9 0.3 0.8
High blood pressure (siblings) 2.2 3.1 4.5 1.9 -1.9 0.7 -2.1
Forced vital capacity (FVC), Best measure 0.1 0.2 0.4 0.7 0.5 -0.5 -0.2
Body fat percentage 1.3 5.2 7.5 -2.7 2.4 0.5 2.7
Leg fat percentage (right) 0.5 1.9 3.2 -1.8 1.1 -0.1 1.8
Arm fat-free mass (right) 0.6 3.2 6.6 2.6 -1.6 -0.1 -1.9
Exposure to tobacco smoke outside home 1.9 2.6 3.5 -1.8 1.6 1.1 1.9
Comparative body size at age 10 0.1 0.3 0.8 0.5 0.2 0.9 -0.3
Number of full brothers 1.0 1.2 1.8 0.8 -1.3 0.8 -1.3
Worry too long after embarrassment 0.7 1.2 1.8 1.3 -1.1 -0.2 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.5 2.4 1.6 -1.2 -0.1 -1.5
Wheeze or whistling in the chest in last year 3.1 5.5 7.2 -2.6 2.6 1.2 2.7
Number of children fathered 0.9 1.0 1.7 -1.3 0.9 0.9 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.8 -0.5 0.9 -0.1 0.7
Age at first live birth 1.8 3.2 6.4 -1.4 1.3 -2.5 1.6
Pulse wave peak to peak time 0.3 0.3 0.6 0.4 -0.7 0.4 -0.7
Health satisfaction 0.2 0.2 0.5 0.7 -0.2 0.4 -0.4
Shortness of breath walking on level ground 0.4 0.4 0.8 -0.9 -0.2 0.1 0.9
Qualifications: College or University degree 0.2 0.8 1.7 -0.1 1.2 -1.3 0.2
Eye problems/disorders: None of the above 4.0 4.7 8.1 2.8 -2.0 -0.0 -2.6
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.0 0.0 -1.0 0.8 -0.4
Emphysema/chronic bronchitis 1.0 1.1 2.3 -1.2 0.8 -0.3 1.5
Medication for pain relief, constipation, heartburn 0.4 0.6 1.8 0.3 -0.6 -1.3 -0.3
Neck or shoulder pain in last month 0.1 0.2 0.7 -0.1 -0.8 -0.1 0.2
Medication: Blood pressure 1.6 2.8 4.5 2.0 -1.4 0.9 -2.1
Angina (self-reported) 0.2 0.2 0.4 -0.7 0.1 -0.3 0.6
Migraine (self-reported) 1.6 2.0 2.9 -1.2 1.4 1.3 1.7
Medication: Ibuprofen 0.1 0.1 0.3 -0.4 -0.1 0.0 0.6
Medication: Allopurinol 0.3 0.5 0.5 -0.7 0.7 0.7 0.6
Medication: Omeprazole 0.8 0.9 3.3 0.5 0.2 1.8 -0.4
Medication: Seretide 50 evohaler 3.0 3.5 6.4 -2.5 1.8 -0.2 2.1
Mean time to correctly identify matches 0.1 0.1 0.4 -0.2 0.6 -0.4 0.3
Heart disease (mother) 0.1 0.1 0.4 0.3 0.1 -0.6 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 2.0 -0.6 0.1 -1.4 0.2
Whole body fat mass 0.7 3.0 4.3 -1.9 2.0 0.4 2.1
Leg fat mass (right) 0.3 1.2 2.0 -1.2 1.2 0.1 1.4
Arm predicted mass (right) 0.5 2.6 5.8 2.4 -1.3 -0.4 -1.7
Pulse rate, automated reading 0.4 1.3 1.9 -0.9 0.9 -1.4 1.2
Alcohol intake frequency. 0.1 0.1 0.2 0.1 -0.4 0.4 -0.4
Comparative height size at age 10 1.5 8.5 14.4 3.8 -2.4 0.7 -3.7
Number of full sisters 1.3 1.5 2.2 -1.5 1.4 0.1 1.5
Suffer from ‘nerves’ 0.5 0.7 2.3 0.5 -0.6 1.5 -0.0
Overall health rating 1.6 3.4 4.4 2.1 -1.9 1.4 -1.9
Chest pain or discomfort 0.4 0.6 1.1 -1.1 -0.2 -0.1 1.0
Had major operations 0.6 0.7 0.9 0.7 -1.0 -0.8 -1.0
Age at last live birth 1.6 2.3 3.1 -1.3 1.4 -1.7 1.8
Family relationship satisfaction 1.4 1.8 2.9 1.7 -1.2 -0.5 -1.6
Leg pain on walking 0.2 0.3 0.6 -0.4 0.7 -0.4 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 2.0 0.8 -1.4 -0.6 -0.8
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.6 -0.6 -0.0 -1.6 -0.1
Illness, injury, bereavement, stress in last 2 years 1.7 2.1 2.7 -1.6 0.9 -1.5 1.6
Medication: Aspirin 0.6 0.7 1.5 -0.6 1.2 -0.7 0.7
Supplements: Vitamin C 1.1 1.2 3.1 -0.8 1.8 0.1 1.1
Knee pain experienced in last month 0.1 0.1 0.2 0.3 -0.4 0.5 -0.0
Hypertension (Self-reported) 4.3 11.8 15.9 3.8 -3.8 1.6 -4.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.2 -0.6 1.1 0.4 0.9
Illnesses of father: Heart disease 2.8 3.9 5.6 2.3 -2.1 0.4 -2.4
Illnesses of siblings: Diabetes 1.4 1.7 3.1 -1.3 1.1 0.8 1.8
Smoking status: Previous 1.3 1.9 4.6 -1.2 0.8 2.1 1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.2 0.6 -0.6 -1.1 -0.8
Whole body fat-free mass 0.4 2.1 4.7 2.2 -1.2 -0.0 -1.5
Leg fat-free mass (right) 0.1 0.4 0.7 0.2 0.9 0.8 0.5
Arm fat percentage (left) 2.2 8.7 12.0 -3.3 3.2 1.2 3.5
Average weekly red wine intake 1.1 1.6 2.6 -1.4 1.6 -0.2 1.3
Handedness (chirality/laterality): Left-handed 0.8 1.0 1.8 1.3 -1.1 0.2 -1.0
Mood swings 0.5 1.0 1.6 1.3 -0.8 -0.2 -1.2
Loneliness, isolation 0.3 0.4 0.9 0.6 -1.0 0.5 -0.3
Long-standing illness, disability or infirmity 0.9 1.4 4.0 1.1 -0.5 2.0 -0.4
Ever had bowel cancer screening 0.5 0.6 1.3 0.7 -0.6 1.1 -0.5
Diabetes diagnosed by doctor 0.9 1.5 2.8 1.7 -0.7 1.3 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 2.1 2.3 5.1 -1.5 2.3 0.2 1.3
Friendships satisfaction 6.0 7.4 10.4 3.2 -2.9 -0.7 -3.2
Qualifications: nursing, teaching 0.7 1.2 1.5 0.9 -1.2 -0.9 -1.2
Commuting to job workplace: Walk 0.1 0.2 0.5 -0.0 -0.2 0.7 0.2
Eye problems/disorders: Cataract 2.5 2.9 4.9 -1.7 2.2 0.8 1.8
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 2.4 -1.1 1.5 0.8 1.5
Medication for cholesterol 1.7 2.6 3.6 -1.9 1.0 -1.6 1.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 1.8 -1.1 1.4 1.1 1.3
Back pain experienced in last month 0.1 0.2 0.4 -0.1 0.4 -0.2 0.7
Mineral and other dietary supplements 2.0 2.7 3.9 -1.7 1.9 0.8 2.0
Breast cancer (self-reported) 1.5 1.8 2.7 -1.4 1.3 -0.9 1.6
Asthma (self-reported) 2.6 5.2 9.1 -3.0 2.1 -0.2 2.7
Osteoporosis (self-reported) 1.4 1.8 2.6 1.0 -1.6 1.5 -1.1
Osteoarthritis (self-reported) 0.2 0.3 0.8 -0.6 0.1 0.9 0.3
Medication: Aspirin 0.5 0.6 1.1 -0.5 1.1 -0.9 0.7
Medication: Gliclazide 0.2 0.3 0.6 0.4 -0.5 0.7 -0.2
Illnesses of father: None of the above (group 1) 0.5 0.6 1.1 -1.0 0.7 0.5 0.9
Smoking status: Current 1.1 1.7 2.5 1.6 -1.0 0.9 -1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 2.0 2.9 -1.3 1.3 1.7 1.3
Whole body water mass 0.4 2.4 5.4 2.3 -1.3 0.1 -1.6
Leg predicted mass (right) 0.1 0.4 0.6 0.3 0.8 0.8 0.5
Arm fat mass (left) 0.6 2.7 3.8 -1.7 1.9 0.7 2.0
Number of self-reported non-cancer illnesses 0.4 0.8 2.0 -0.7 0.1 1.4 0.7
Average weekly champagne plus white wine intake 0.5 0.7 1.1 1.1 -0.8 -0.1 -0.9
Miserableness 0.5 0.8 1.7 -0.9 1.3 0.4 0.8
Guilty feelings 0.1 0.2 0.3 -0.5 -0.2 0.5 0.0
Wears glasses or contact lenses 0.7 0.8 2.1 -0.4 1.4 0.8 0.4
Ever taken oral contraceptive pill 0.4 0.5 0.8 0.6 -0.9 -0.5 -0.7
Hearing aid user 0.3 0.3 0.5 0.7 0.2 0.3 -0.7
Mother’s age at death 0.5 0.6 1.0 1.0 -0.8 0.1 -0.9
Financial situation satisfaction 1.0 1.2 3.5 0.7 -0.4 1.9 -0.7
Tinnitus: Yes, now most or all of the time 0.5 0.6 0.8 0.7 -0.9 0.9 -0.6
Commuting to job workplace: Public transport 0.8 1.0 3.7 0.3 0.1 1.9 -0.3
Eye problems/disorders: Glaucoma 0.7 0.9 1.2 -1.0 1.0 0.6 1.1
Medication: Blood pressure 6.1 11.7 17.9 4.2 -3.1 1.6 -4.1
Pain type(s) experienced in last month: Hip pain 1.9 2.4 3.9 1.7 -2.0 -0.3 -1.6
Supplements: Fish oil (including cod liver oil) 2.4 3.2 3.6 1.8 -1.9 -1.6 -1.8
High cholesterol (Self-reported) 0.7 1.2 3.5 0.7 -0.3 1.9 -0.9
Medication: Bendroflumethiazide 6.4 9.8 14.1 3.6 -3.4 0.8 -3.8
Medication: Paracetamol 0.1 0.2 0.3 -0.5 -0.3 -0.5 0.4
Medication: Lisinopril 4.2 5.5 9.7 3.1 -1.6 0.5 -3.1
Medication: Atorvastatin 0.3 0.4 0.7 -0.8 0.9 -0.0 0.6
Illnesses of father: High blood pressure 2.6 3.2 6.3 2.5 -1.3 0.2 -2.1
Alcohol drinker status: Never 1.1 1.3 2.4 1.5 -0.8 0.4 -1.5
Ever smoked 1.1 1.9 5.9 -0.8 0.8 2.4 0.6
Basal metabolic rate 0.2 0.9 2.4 1.6 -0.6 0.1 -0.9
Leg fat percentage (left) 0.9 3.4 5.3 -2.3 1.8 -0.2 2.3
Arm fat-free mass (left) 0.6 3.0 6.0 2.5 -1.6 -0.0 -1.9
Number of operations (self-reported) 0.1 0.2 0.5 -0.7 -0.1 -0.4 0.2
Average weekly beer plus cider intake 0.4 0.6 1.5 -0.5 0.2 1.2 0.7
Irritability 2.7 4.6 8.3 2.9 -1.9 0.1 -2.5
Risk taking 2.0 3.0 4.0 -2.0 1.8 1.0 1.9
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.7 0.2 0.3 0.8 0.3
Fractured/broken bones in last 5 years 0.5 0.7 1.0 -0.6 0.7 -0.9 1.0
Age started oral contraceptive pill 0.5 0.6 1.1 -1.1 0.5 0.6 0.8
Diastolic blood pressure, automated reading 0.1 0.2 0.5 -0.7 0.2 0.3 0.4
Ever depressed for a whole week 0.3 0.4 0.6 0.8 -0.4 0.5 -0.6
Unable to work because of sickness or disability 0.4 0.6 0.8 0.7 -0.3 0.8 -0.9
Commuting to job workplace: Cycle 0.8 0.9 2.3 -0.6 1.5 0.5 0.9
Myopia 0.7 1.0 1.9 1.4 0.1 -0.9 -1.1
Vascular/heart problems diagnosed by doctor 2.5 6.8 9.2 -3.0 2.9 -1.0 3.0
Cholesterol lowering medication 0.9 1.3 4.8 0.4 -0.4 2.2 -0.2
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 2.5 0.4 0.2 1.6 -0.4
Pain experienced in last month 0.1 0.1 0.2 0.1 -0.3 0.4 -0.4
Supplements: Calcium 0.4 0.5 1.2 0.7 -0.1 1.1 -0.4
Basal cell carcinoma (self-reported) 0.1 0.1 0.2 -0.5 -0.3 -0.4 0.1
Heart attack/myocardial infarction (self-reported) 0.3 0.3 0.7 -0.1 0.8 -0.9 0.2
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.5 -0.7 0.7 0.1 0.2
Heart disease (siblings) 0.3 0.4 0.5 -0.5 0.7 0.7 0.6
Alcohol drinker status: Previous 0.4 0.4 0.8 -0.9 0.6 0.1 0.8
Pack years of smoking 0.0 0.0 0.1 0.1 0.1 -0.3 0.0
Impedance of whole body 0.2 1.1 2.5 -1.2 0.2 -1.6 0.6
Leg fat mass (left) 0.4 1.6 2.5 -1.4 1.4 0.0 1.6
Arm predicted mass (left) 0.6 2.9 5.4 2.3 -1.7 -0.0 -1.8