Hub : Genes

MRPL23

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.0930	0.0360	3.1e-03	0.004	NA	-0.003	NA	-0.003	1.3e-01	NA	7.2e-01	NA	6.5e-01
2	ROSMAP	Brain Pre-frontal Cortex	0.1484	0.0340	2.4e-09	0.111	0.090	0.110	0.109	0.108	3.8e-14	1.4e-11	5.9e-14	7.2e-14	1.0e-13
3	YFS	Blood	0.2237	0.0326	0.0e+00	0.037	0.089	0.103	0.089	0.071	3.6e-12	1.9e-27	6.9e-32	1.0e-27	4.2e-22
4	TCGA	Brain Lower Grade Glioma	0.0379	0.0199	4.7e-05	0.062	0.044	0.036	NA	0.055	1.4e-07	9.2e-06	6.0e-05	NA	7.5e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.1	3.4	0.6	-0.4	1.8	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.5	0.9	-0.6	0.1	0.9	0.8
Depressed Affect (Nagel 2018)	0.3	0.6	1.0	0.8	-0.8	-0.3	-1.0
Depression (Nagel 2018)	1.3	2.0	4.0	1.5	-1.1	0.7	-2.0
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.1	0.7	-0.5	-1.0	-1.0
Neuroticism (Nagel 2018)	0.7	1.7	2.8	1.5	-1.3	0.1	-1.7
Schizophrenia (2018)	0.5	0.9	1.8	-1.3	0.5	-0.4	1.3
Schizophrenia vs Biploar Disorder	1.5	2.0	5.9	-1.1	-0.2	-2.4	0.9
Worry (Nagel 2018)	0.5	1.1	1.7	1.2	-1.2	0.0	-1.3
Alzheimer’s Disease (in mother)	1.0	1.2	4.5	-0.4	-0.3	-2.1	0.4
Alzheimer’s Disease (in father)	0.4	0.4	0.8	-0.6	0.5	-0.4	0.9
Alzheimer’s Disease (including proxy)	1.0	1.4	4.2	-0.7	0.2	-2.1	0.9
Crohns Disease (2017)	0.3	0.6	1.4	1.2	-0.4	-0.2	-1.0
Irritable Bowel Disease (IBD)	0.7	1.7	3.5	1.9	-0.7	-0.5	-1.6
Ulcerative Colitis (UC)	0.3	0.5	1.2	1.1	0.3	-0.3	-0.9
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.2	0.4	1.3	0.1	0.4	-1.1	-0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.1	4.1	-0.4	0.3	-2.0	0.4
Breast Cancer	9.7	23.4	37.8	5.6	-4.9	-0.5	-6.2
Ovarian Cancer	0.8	1.0	3.7	-0.4	0.3	1.9	0.1
Prostate Cancer	0.7	1.0	3.4	0.4	-0.4	1.8	-0.6
Age at First Birth	0.7	1.1	1.8	1.3	-0.4	-1.0	-1.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	2.7	-0.0	0.1	-1.6	0.3
Coronary Artery Disease (CAD)	2.3	2.8	8.2	2.9	-1.6	0.6	0.0
Crohns Disease (2012)	0.3	0.5	1.3	0.5	1.1	-0.5	-0.1
Mean Putamen Volume	3.5	4.0	5.4	2.1	-1.9	1.7	-2.3
Fasting Glucose	1.2	1.4	2.0	1.3	-0.4	1.4	-1.4
HbA1C	0.6	0.7	1.5	0.8	-0.3	1.2	-0.7
HDL Cholesterol	0.2	0.3	0.4	0.6	-0.4	-0.5	-0.6
LDL Cholesterol	0.4	0.6	2.4	-0.3	0.3	-1.5	0.2
Lupus	0.8	1.2	2.2	-0.4	1.5	1.5	0.6
Neuroticism (2016)	0.3	0.4	0.7	-0.5	-0.7	0.8	0.6
Primary Biliary Cirrhosis	1.7	2.4	5.1	1.3	-2.3	0.2	-1.7
Rheumatoid Arthritis	0.4	0.6	1.1	0.3	1.0	-1.0	0.1
Schizophrenia (2014)	0.1	0.1	0.3	-0.4	-0.3	-0.1	0.5
Triglycerides	0.7	1.2	4.2	-0.5	0.5	-2.0	0.5
Type 2 Diabetes (T2D) (2012)	1.8	2.1	3.8	1.9	-1.3	-0.0	-1.7
Ulcerative Colitis	0.3	0.4	0.8	0.9	-0.2	0.5	-0.7
Blood Eosinophil Count	0.1	0.9	1.4	-1.1	0.8	-0.7	1.2
Blood Platelet Count	0.8	8.9	12.7	-3.3	3.6	-0.9	3.3
Blood Red Count	0.5	4.8	8.1	-1.9	2.8	0.9	2.6
Blood White Count	0.3	2.0	5.2	-0.9	2.3	0.1	1.4
Heel T-Score	0.0	0.3	0.7	0.5	0.3	-0.8	-0.3
BMI	0.4	2.2	3.5	-1.3	1.7	0.8	1.9
Height	0.6	10.8	16.6	4.1	-3.9	0.2	-3.4
Waist Hip Ratio (WHR)	0.3	1.4	2.1	-1.4	0.8	0.9	1.4
Systolic Blood Pressure	4.5	22.5	37.9	5.5	-4.7	0.6	-6.2
Smoking Status	0.5	1.1	3.2	-0.7	0.6	1.8	0.4
Allergy or Eczema	0.6	1.5	2.9	-0.7	1.2	-1.7	1.0
Cardiovascular Disease	1.9	6.2	8.6	2.8	-2.5	1.3	-2.9
Hypothyroidism (self reported)	0.7	1.7	2.2	1.2	-1.5	-1.4	-1.1
Respiratory disease	4.6	10.2	15.8	-4.0	3.4	0.2	3.6
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.4	1.4	-0.1	1.8	-0.9
Lung FEV1/FVC ratio	0.7	3.6	8.9	-1.8	-0.2	-3.0	1.4
Lung FVC	0.0	0.2	0.8	-0.1	0.2	0.9	0.3
Neuroticism	0.6	1.4	1.8	1.1	-1.0	1.1	-1.3
Chronotype (morning person)	0.4	1.0	2.1	-0.9	-0.3	-1.4	0.9
Hair Pigment	0.1	2.8	11.1	-0.1	0.1	-3.3	-0.1
Tanning	0.3	3.4	4.1	-1.6	1.9	2.0	1.7
Hand grip strength (left)	0.5	1.4	2.0	1.0	-1.4	-1.2	-1.0
Number of treatments/medications taken	0.5	1.0	2.3	-0.9	0.6	1.5	0.7
Average weekly spirits intake	0.3	0.3	0.7	-0.2	0.8	0.7	0.1
Sensitivity / hurt feelings	0.2	0.4	0.9	-0.2	1.0	0.6	0.4
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.8	1.2	-0.8	0.5	-1.4
Hearing difficulty/problems: Yes	0.3	0.4	1.2	0.5	0.1	-1.1	-0.5
Relative age of first facial hair	1.1	2.2	2.9	1.3	-1.3	-1.7	-1.6
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	3.7	1.9	-1.7	-0.9	-1.9
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.7	0.6	-0.1	1.3	-0.7
Ever had hysterectomy (womb removed)	0.3	0.4	0.7	-0.4	-0.8	0.8	-0.3
Systolic blood pressure, automated reading	1.0	2.8	5.8	1.7	-1.4	0.8	-2.4
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.3	-1.5	0.1	-1.0	1.4
Angina	0.2	0.3	0.5	-0.7	0.1	-0.6	0.6
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.2	-0.3	0.5	-0.2
Vitamin and mineral supplements	0.0	0.0	0.1	-0.0	-0.2	0.3	0.1
Supplements: Zinc	2.3	2.5	4.5	2.1	-1.6	0.2	-1.7
Medication: Co-codamol	1.3	1.5	2.0	-1.2	1.0	-1.4	1.2
Medication: Metformin	0.4	0.6	1.1	0.8	-0.6	1.0	-0.5
Diabetes (father)	0.1	0.1	0.4	0.6	0.2	0.0	-0.3
Diabetes (mother)	0.5	0.6	1.0	-0.5	1.0	0.9	0.6
Severe depression (siblings)	0.6	0.6	1.1	0.9	-1.0	0.2	-0.8
Pack years adult smoking proportion	0.1	0.1	0.5	0.1	0.2	-0.7	-0.1
Impedance of leg (right)	0.9	4.1	8.5	0.8	-2.2	-2.9	-1.6
Leg fat-free mass (left)	0.1	0.3	0.7	0.5	0.6	0.8	0.2
Trunk fat percentage	1.7	6.7	9.5	-3.0	2.8	0.6	3.1
Hand grip strength (right)	0.3	0.9	1.4	0.7	-1.2	-1.1	-0.7
Townsend deprivation index at recruitment	0.6	0.8	2.4	0.4	-0.7	1.5	-0.2
Current tobacco smoking	1.1	1.8	2.8	1.6	-1.1	0.8	-1.7
Average weekly fortified wine intake	0.0	0.1	0.1	-0.3	-0.3	0.0	0.2
Maternal smoking around birth	0.2	0.3	0.6	-0.8	0.3	0.4	0.7
Fed-up feelings	1.1	2.0	2.9	1.7	-1.4	0.6	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.1	1.0	-0.6	0.4	-1.0
Relative age voice broke	0.4	0.7	2.2	0.4	0.4	-1.5	-0.4
Taking other prescription medications	0.2	0.3	0.7	-0.4	0.3	0.8	0.4
Age when periods started (menarche)	2.4	5.7	9.9	-3.0	1.9	0.5	3.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.5	-0.3	-0.7	-0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.0	-0.9	0.7	0.1	1.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.7	0.4	-0.2	-0.8	-0.7
Qualifications: CSEs or equivalent	0.3	0.4	0.8	0.6	-0.9	-0.2	-0.8
Serious illness, injury or assault to yourself	0.4	0.5	0.9	0.6	0.8	0.9	-0.3
High blood pressure	3.8	10.7	13.8	3.6	-3.7	1.5	-3.7
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.1	-0.3	0.9	-1.0	0.5
Multivitamins +/- minerals	0.3	0.4	0.6	-0.8	0.6	-0.5	0.5
Stomach or abdominal pain in last month	0.7	0.9	1.2	-1.0	0.5	1.1	1.0
Supplements: Glucosamine	0.1	0.1	0.4	-0.6	-0.4	-0.1	0.2
Diverticular disease/diverticulitis (self-reported)	3.2	3.8	5.8	-1.5	2.4	2.1	1.7
Medication: Atenolol	3.3	4.1	6.3	2.4	-2.1	0.3	-2.5
Medication: Levothyroxine sodium	1.2	2.0	3.5	1.4	-1.9	-0.9	-1.2
Sitting height	1.1	8.0	13.0	3.6	-2.2	-2.5	-2.9
Chronic bronchitis/emphysema (father)	1.8	2.1	3.8	-1.4	1.9	0.8	1.4
High blood pressure (mother)	3.9	5.5	8.4	2.6	-1.2	-2.9	-2.4
Body mass index (BMI)	0.8	3.2	4.5	-1.9	2.0	0.9	2.1
Impedance of leg (left)	0.7	3.3	10.4	0.1	-1.4	-3.2	-0.9
Leg predicted mass (left)	0.1	0.3	0.7	0.5	0.4	0.9	0.2
Trunk fat mass	0.8	3.2	4.9	-1.9	2.1	0.4	2.2
Waist circumference	0.8	2.9	4.8	-1.8	1.8	0.5	2.2
Number of incorrect matches in round	4.8	8.0	11.6	3.4	-3.3	0.1	-3.1
Past tobacco smoking	1.4	2.6	7.6	1.0	-0.8	-2.8	-0.9
Alcohol usually taken with meals	0.2	0.4	0.7	-0.6	0.9	-0.6	0.3
Nervous feelings	2.0	3.7	5.9	2.0	-2.4	-1.1	-1.9
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.8	2.0	1.4	-1.1	1.4	-1.4
Hearing difficulty/problems with background noise	1.1	1.8	2.4	1.6	-1.2	-1.1	-1.5
Hair/balding pattern: Pattern 2	0.4	0.4	1.5	0.5	0.2	1.2	-0.1
Had menopause	1.8	2.2	5.1	-1.1	0.9	2.3	1.2
Had other major operations	0.6	0.8	1.6	-0.6	1.3	1.0	0.5
Forced vital capacity (FVC)	0.2	0.9	1.7	1.3	-0.3	-0.9	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.4	-0.7	0.6	-0.9	1.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	0.9	-0.6	0.7	1.0	0.7
Qualifications: None of the above	0.5	1.1	2.9	-0.9	-0.0	1.7	0.9
Financial difficulties in last 2 years	0.2	0.3	1.2	-0.1	0.4	1.1	0.2
Mouth/teeth dental problems	0.3	0.4	1.1	-0.4	1.0	-0.5	0.3
Heart attack	0.3	0.4	1.2	-0.1	0.6	-1.1	0.2
Allergy	1.7	3.9	4.8	2.1	-2.2	1.3	-2.2
Pain all over the body in last month	0.5	0.6	1.9	-0.1	-0.5	1.4	-0.3
Diabetes (self-reported)	0.6	0.9	1.5	1.2	-0.7	0.8	-0.8
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.8	0.3	-0.6	-1.9	-0.1
Medication: Ramipril	2.9	3.7	5.1	2.0	-2.1	1.1	-2.2
Medication: Simvastatin	0.4	0.5	1.3	1.1	0.2	0.6	-0.6
Fluid intelligence score	0.8	1.6	3.7	1.0	-0.8	-1.9	-1.0
Illnesses of siblings	0.2	0.2	0.8	0.0	0.5	0.9	-0.1
Neuroticism score	0.9	1.9	2.3	1.5	-1.4	1.0	-1.5
Weight	0.1	0.3	0.6	-0.1	0.7	0.6	0.6
Impedance of arm (right)	0.4	2.0	3.9	-2.0	1.2	-0.4	1.6
Arm fat percentage (right)	1.9	7.6	10.4	-3.2	2.9	1.2	3.2
Trunk fat-free mass	0.9	5.2	9.8	3.1	-2.2	-0.5	-2.4
Hip circumference	0.1	0.6	1.0	-0.5	0.9	-0.5	1.0
Time employed in main current job	0.1	0.1	0.3	-0.2	-0.3	0.5	-0.1
Alcohol intake versus 10 years previously	1.0	1.5	3.5	1.1	-1.9	-0.6	-1.0
Father’s age at death	0.8	1.1	1.4	-1.2	1.1	-0.6	1.2
Worrier / anxious feelings	0.1	0.3	0.5	0.7	0.1	0.6	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	2.1	1.2	-1.5	1.4	-1.3
Falls in the last year	2.8	3.8	5.9	2.4	-1.7	0.9	-2.4
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	-0.3	0.7	-0.4	0.2
Number of live births	0.8	1.1	3.1	-0.7	0.7	1.8	0.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	5.8	0.6	-0.0	-2.4	-0.3
Pulse rate	0.5	0.8	1.3	-0.6	1.1	-0.9	0.9
Happiness	3.9	4.8	7.4	2.7	-2.2	-0.1	-2.7
Noisy workplace	0.2	0.3	0.4	0.5	0.4	0.4	-0.7
Qualifications: A levels/AS levels or equivalent	1.0	2.3	3.9	2.0	-1.1	-1.2	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.8	-0.7	0.3	0.9	0.3
Mouth/teeth dental problems: Dentures	0.4	0.6	2.4	-0.1	0.3	1.6	0.2
Asthma	2.8	5.5	9.2	-3.0	2.2	-0.4	2.8
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.2	-0.5	0.3	-0.2
Medication: Cholesterol lowering	0.8	1.2	2.6	1.6	-0.0	0.4	-1.4
Depression (self-reported)	1.2	1.4	2.8	1.0	-1.0	1.7	-0.9
Medication: Lansoprazole	1.0	1.1	1.8	-0.9	1.3	1.0	1.0
Prospective memory result	0.9	1.1	2.4	-0.6	0.8	1.6	1.0
Lung cancer (father)	0.3	0.4	0.5	0.5	-0.7	-0.5	-0.7
Illnesses of mother	2.5	3.0	4.1	-2.0	1.3	1.9	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	3.4	0.0	0.6	-1.9	0.4
Pulse wave Arterial Stiffness index	0.2	0.3	0.4	-0.3	0.6	-0.5	0.7
Impedance of arm (left)	0.6	2.8	5.0	-2.2	1.6	-0.2	1.9
Arm fat mass (right)	0.9	3.8	5.3	-2.1	2.2	0.8	2.3
Trunk predicted mass	1.0	5.6	10.5	3.2	-2.3	-0.4	-2.5
Standing height	0.8	8.0	13.4	3.7	-2.8	-0.9	-3.2
Length of working week for main job	0.4	0.5	1.5	-0.4	1.2	-0.5	0.3
Exposure to tobacco smoke at home	0.7	0.8	2.7	0.4	-0.4	1.6	-0.5
Breastfed as a baby	0.1	0.1	0.2	0.3	-0.5	0.3	-0.0
Tense / ‘highly strung’	0.3	0.5	0.6	0.6	-0.8	0.8	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.5	3.8	1.9	-1.4	1.2	-1.7
Hair/balding pattern: Pattern 4	0.1	0.3	0.8	-0.3	-0.7	0.9	-0.1
Birth weight of first child	1.7	3.1	8.0	1.3	-0.9	2.8	-1.3
Peak expiratory flow (PEF)	1.1	2.5	3.5	-1.4	1.2	-1.9	1.8
Pulse wave reflection index	0.0	0.0	0.1	-0.2	-0.2	-0.3	0.2
Ever highly irritable/argumentative for 2 days	0.8	1.0	1.9	1.4	-0.5	0.1	-1.3
Loud music exposure frequency	1.2	1.3	2.1	1.1	-1.4	0.2	-1.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.1	0.3	1.0	-1.5	0.0
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.4	1.1	-1.2	-0.6	-1.0
Blood clot in the leg (DVT)	0.3	0.4	0.7	-0.9	0.8	0.3	0.4
Medication: Paracetamol	0.1	0.2	0.3	0.1	-0.6	0.5	-0.2
Headache pain in last month	0.1	0.2	0.2	-0.5	0.3	0.4	0.4
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.4	-1.6	0.3	-0.7	1.5
Glaucoma (self-reported)	0.5	0.6	0.8	-0.7	0.9	0.8	0.7
Gout (self-reported)	0.3	0.5	0.7	-0.5	0.9	0.7	0.7
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	4.1	1.2	-2.0	-1.3	-1.1
Medication: Amlodipine	1.9	2.6	5.0	1.6	-1.5	0.9	-2.2
Medication: Ventolin 100micrograms inhaler	1.6	2.1	3.2	-1.8	1.5	0.2	1.7
Birth weight	0.6	1.4	4.3	0.8	0.2	2.1	-0.7
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.8	-0.5	0.9	0.3	0.8
High blood pressure (siblings)	2.2	3.1	4.5	1.9	-1.9	0.7	-2.1
Forced vital capacity (FVC), Best measure	0.1	0.2	0.4	0.7	0.5	-0.5	-0.2
Body fat percentage	1.3	5.2	7.5	-2.7	2.4	0.5	2.7
Leg fat percentage (right)	0.5	1.9	3.2	-1.8	1.1	-0.1	1.8
Arm fat-free mass (right)	0.6	3.2	6.6	2.6	-1.6	-0.1	-1.9
Exposure to tobacco smoke outside home	1.9	2.6	3.5	-1.8	1.6	1.1	1.9
Comparative body size at age 10	0.1	0.3	0.8	0.5	0.2	0.9	-0.3
Number of full brothers	1.0	1.2	1.8	0.8	-1.3	0.8	-1.3
Worry too long after embarrassment	0.7	1.2	1.8	1.3	-1.1	-0.2	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	2.4	1.6	-1.2	-0.1	-1.5
Wheeze or whistling in the chest in last year	3.1	5.5	7.2	-2.6	2.6	1.2	2.7
Number of children fathered	0.9	1.0	1.7	-1.3	0.9	0.9	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.8	-0.5	0.9	-0.1	0.7
Age at first live birth	1.8	3.2	6.4	-1.4	1.3	-2.5	1.6
Pulse wave peak to peak time	0.3	0.3	0.6	0.4	-0.7	0.4	-0.7
Health satisfaction	0.2	0.2	0.5	0.7	-0.2	0.4	-0.4
Shortness of breath walking on level ground	0.4	0.4	0.8	-0.9	-0.2	0.1	0.9
Qualifications: College or University degree	0.2	0.8	1.7	-0.1	1.2	-1.3	0.2
Eye problems/disorders: None of the above	4.0	4.7	8.1	2.8	-2.0	-0.0	-2.6
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.0	0.0	-1.0	0.8	-0.4
Emphysema/chronic bronchitis	1.0	1.1	2.3	-1.2	0.8	-0.3	1.5
Medication for pain relief, constipation, heartburn	0.4	0.6	1.8	0.3	-0.6	-1.3	-0.3
Neck or shoulder pain in last month	0.1	0.2	0.7	-0.1	-0.8	-0.1	0.2
Medication: Blood pressure	1.6	2.8	4.5	2.0	-1.4	0.9	-2.1
Angina (self-reported)	0.2	0.2	0.4	-0.7	0.1	-0.3	0.6
Migraine (self-reported)	1.6	2.0	2.9	-1.2	1.4	1.3	1.7
Medication: Ibuprofen	0.1	0.1	0.3	-0.4	-0.1	0.0	0.6
Medication: Allopurinol	0.3	0.5	0.5	-0.7	0.7	0.7	0.6
Medication: Omeprazole	0.8	0.9	3.3	0.5	0.2	1.8	-0.4
Medication: Seretide 50 evohaler	3.0	3.5	6.4	-2.5	1.8	-0.2	2.1
Mean time to correctly identify matches	0.1	0.1	0.4	-0.2	0.6	-0.4	0.3
Heart disease (mother)	0.1	0.1	0.4	0.3	0.1	-0.6	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.0	-0.6	0.1	-1.4	0.2
Whole body fat mass	0.7	3.0	4.3	-1.9	2.0	0.4	2.1
Leg fat mass (right)	0.3	1.2	2.0	-1.2	1.2	0.1	1.4
Arm predicted mass (right)	0.5	2.6	5.8	2.4	-1.3	-0.4	-1.7
Pulse rate, automated reading	0.4	1.3	1.9	-0.9	0.9	-1.4	1.2
Alcohol intake frequency.	0.1	0.1	0.2	0.1	-0.4	0.4	-0.4
Comparative height size at age 10	1.5	8.5	14.4	3.8	-2.4	0.7	-3.7
Number of full sisters	1.3	1.5	2.2	-1.5	1.4	0.1	1.5
Suffer from ‘nerves’	0.5	0.7	2.3	0.5	-0.6	1.5	-0.0
Overall health rating	1.6	3.4	4.4	2.1	-1.9	1.4	-1.9
Chest pain or discomfort	0.4	0.6	1.1	-1.1	-0.2	-0.1	1.0
Had major operations	0.6	0.7	0.9	0.7	-1.0	-0.8	-1.0
Age at last live birth	1.6	2.3	3.1	-1.3	1.4	-1.7	1.8
Family relationship satisfaction	1.4	1.8	2.9	1.7	-1.2	-0.5	-1.6
Leg pain on walking	0.2	0.3	0.6	-0.4	0.7	-0.4	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.0	0.8	-1.4	-0.6	-0.8
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.6	-0.6	-0.0	-1.6	-0.1
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	2.7	-1.6	0.9	-1.5	1.6
Medication: Aspirin	0.6	0.7	1.5	-0.6	1.2	-0.7	0.7
Supplements: Vitamin C	1.1	1.2	3.1	-0.8	1.8	0.1	1.1
Knee pain experienced in last month	0.1	0.1	0.2	0.3	-0.4	0.5	-0.0
Hypertension (Self-reported)	4.3	11.8	15.9	3.8	-3.8	1.6	-4.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.2	-0.6	1.1	0.4	0.9
Illnesses of father: Heart disease	2.8	3.9	5.6	2.3	-2.1	0.4	-2.4
Illnesses of siblings: Diabetes	1.4	1.7	3.1	-1.3	1.1	0.8	1.8
Smoking status: Previous	1.3	1.9	4.6	-1.2	0.8	2.1	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.2	0.6	-0.6	-1.1	-0.8
Whole body fat-free mass	0.4	2.1	4.7	2.2	-1.2	-0.0	-1.5
Leg fat-free mass (right)	0.1	0.4	0.7	0.2	0.9	0.8	0.5
Arm fat percentage (left)	2.2	8.7	12.0	-3.3	3.2	1.2	3.5
Average weekly red wine intake	1.1	1.6	2.6	-1.4	1.6	-0.2	1.3
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.8	1.3	-1.1	0.2	-1.0
Mood swings	0.5	1.0	1.6	1.3	-0.8	-0.2	-1.2
Loneliness, isolation	0.3	0.4	0.9	0.6	-1.0	0.5	-0.3
Long-standing illness, disability or infirmity	0.9	1.4	4.0	1.1	-0.5	2.0	-0.4
Ever had bowel cancer screening	0.5	0.6	1.3	0.7	-0.6	1.1	-0.5
Diabetes diagnosed by doctor	0.9	1.5	2.8	1.7	-0.7	1.3	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	5.1	-1.5	2.3	0.2	1.3
Friendships satisfaction	6.0	7.4	10.4	3.2	-2.9	-0.7	-3.2
Qualifications: nursing, teaching	0.7	1.2	1.5	0.9	-1.2	-0.9	-1.2
Commuting to job workplace: Walk	0.1	0.2	0.5	-0.0	-0.2	0.7	0.2
Eye problems/disorders: Cataract	2.5	2.9	4.9	-1.7	2.2	0.8	1.8
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	2.4	-1.1	1.5	0.8	1.5
Medication for cholesterol	1.7	2.6	3.6	-1.9	1.0	-1.6	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	1.8	-1.1	1.4	1.1	1.3
Back pain experienced in last month	0.1	0.2	0.4	-0.1	0.4	-0.2	0.7
Mineral and other dietary supplements	2.0	2.7	3.9	-1.7	1.9	0.8	2.0
Breast cancer (self-reported)	1.5	1.8	2.7	-1.4	1.3	-0.9	1.6
Asthma (self-reported)	2.6	5.2	9.1	-3.0	2.1	-0.2	2.7
Osteoporosis (self-reported)	1.4	1.8	2.6	1.0	-1.6	1.5	-1.1
Osteoarthritis (self-reported)	0.2	0.3	0.8	-0.6	0.1	0.9	0.3
Medication: Aspirin	0.5	0.6	1.1	-0.5	1.1	-0.9	0.7
Medication: Gliclazide	0.2	0.3	0.6	0.4	-0.5	0.7	-0.2
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	-1.0	0.7	0.5	0.9
Smoking status: Current	1.1	1.7	2.5	1.6	-1.0	0.9	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	2.9	-1.3	1.3	1.7	1.3
Whole body water mass	0.4	2.4	5.4	2.3	-1.3	0.1	-1.6
Leg predicted mass (right)	0.1	0.4	0.6	0.3	0.8	0.8	0.5
Arm fat mass (left)	0.6	2.7	3.8	-1.7	1.9	0.7	2.0
Number of self-reported non-cancer illnesses	0.4	0.8	2.0	-0.7	0.1	1.4	0.7
Average weekly champagne plus white wine intake	0.5	0.7	1.1	1.1	-0.8	-0.1	-0.9
Miserableness	0.5	0.8	1.7	-0.9	1.3	0.4	0.8
Guilty feelings	0.1	0.2	0.3	-0.5	-0.2	0.5	0.0
Wears glasses or contact lenses	0.7	0.8	2.1	-0.4	1.4	0.8	0.4
Ever taken oral contraceptive pill	0.4	0.5	0.8	0.6	-0.9	-0.5	-0.7
Hearing aid user	0.3	0.3	0.5	0.7	0.2	0.3	-0.7
Mother’s age at death	0.5	0.6	1.0	1.0	-0.8	0.1	-0.9
Financial situation satisfaction	1.0	1.2	3.5	0.7	-0.4	1.9	-0.7
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.8	0.7	-0.9	0.9	-0.6
Commuting to job workplace: Public transport	0.8	1.0	3.7	0.3	0.1	1.9	-0.3
Eye problems/disorders: Glaucoma	0.7	0.9	1.2	-1.0	1.0	0.6	1.1
Medication: Blood pressure	6.1	11.7	17.9	4.2	-3.1	1.6	-4.1
Pain type(s) experienced in last month: Hip pain	1.9	2.4	3.9	1.7	-2.0	-0.3	-1.6
Supplements: Fish oil (including cod liver oil)	2.4	3.2	3.6	1.8	-1.9	-1.6	-1.8
High cholesterol (Self-reported)	0.7	1.2	3.5	0.7	-0.3	1.9	-0.9
Medication: Bendroflumethiazide	6.4	9.8	14.1	3.6	-3.4	0.8	-3.8
Medication: Paracetamol	0.1	0.2	0.3	-0.5	-0.3	-0.5	0.4
Medication: Lisinopril	4.2	5.5	9.7	3.1	-1.6	0.5	-3.1
Medication: Atorvastatin	0.3	0.4	0.7	-0.8	0.9	-0.0	0.6
Illnesses of father: High blood pressure	2.6	3.2	6.3	2.5	-1.3	0.2	-2.1
Alcohol drinker status: Never	1.1	1.3	2.4	1.5	-0.8	0.4	-1.5
Ever smoked	1.1	1.9	5.9	-0.8	0.8	2.4	0.6
Basal metabolic rate	0.2	0.9	2.4	1.6	-0.6	0.1	-0.9
Leg fat percentage (left)	0.9	3.4	5.3	-2.3	1.8	-0.2	2.3
Arm fat-free mass (left)	0.6	3.0	6.0	2.5	-1.6	-0.0	-1.9
Number of operations (self-reported)	0.1	0.2	0.5	-0.7	-0.1	-0.4	0.2
Average weekly beer plus cider intake	0.4	0.6	1.5	-0.5	0.2	1.2	0.7
Irritability	2.7	4.6	8.3	2.9	-1.9	0.1	-2.5
Risk taking	2.0	3.0	4.0	-2.0	1.8	1.0	1.9
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.7	0.2	0.3	0.8	0.3
Fractured/broken bones in last 5 years	0.5	0.7	1.0	-0.6	0.7	-0.9	1.0
Age started oral contraceptive pill	0.5	0.6	1.1	-1.1	0.5	0.6	0.8
Diastolic blood pressure, automated reading	0.1	0.2	0.5	-0.7	0.2	0.3	0.4
Ever depressed for a whole week	0.3	0.4	0.6	0.8	-0.4	0.5	-0.6
Unable to work because of sickness or disability	0.4	0.6	0.8	0.7	-0.3	0.8	-0.9
Commuting to job workplace: Cycle	0.8	0.9	2.3	-0.6	1.5	0.5	0.9
Myopia	0.7	1.0	1.9	1.4	0.1	-0.9	-1.1
Vascular/heart problems diagnosed by doctor	2.5	6.8	9.2	-3.0	2.9	-1.0	3.0
Cholesterol lowering medication	0.9	1.3	4.8	0.4	-0.4	2.2	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.5	0.4	0.2	1.6	-0.4
Pain experienced in last month	0.1	0.1	0.2	0.1	-0.3	0.4	-0.4
Supplements: Calcium	0.4	0.5	1.2	0.7	-0.1	1.1	-0.4
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.5	-0.3	-0.4	0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.7	-0.1	0.8	-0.9	0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	-0.7	0.7	0.1	0.2
Heart disease (siblings)	0.3	0.4	0.5	-0.5	0.7	0.7	0.6
Alcohol drinker status: Previous	0.4	0.4	0.8	-0.9	0.6	0.1	0.8
Pack years of smoking	0.0	0.0	0.1	0.1	0.1	-0.3	0.0
Impedance of whole body	0.2	1.1	2.5	-1.2	0.2	-1.6	0.6
Leg fat mass (left)	0.4	1.6	2.5	-1.4	1.4	0.0	1.6
Arm predicted mass (left)	0.6	2.9	5.4	2.3	-1.7	-0.0	-1.8