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chr10:103,313,599-105,647,095

Best TWAS P=5.34e-17 · Best GWAS P=4.68e-15 conditioned to 0.00412

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	CYP17A1-AS1	0.05	0.02	enet	10	0.03	2.8e-03	-5.25	-6.4	2.0e-10	0.68	0.20	0.47	FALSE
2	GTEx	Artery Aorta	NT5C2	0.08	0.02	lasso	7	0.01	1.2e-01	2.93	5.2	1.8e-07	-0.17	0.26	0.26	FALSE
3	GTEx	Artery Aorta	ARL3	0.19	0.07	lasso	6	0.06	4.8e-04	-4.85	5.5	4.4e-08	-0.72	0.31	0.48	FALSE
4	GTEx	Artery Tibial	NT5C2	0.06	0.04	lasso	9	0.02	1.5e-02	-6.12	6.6	3.2e-11	-0.40	0.13	0.67	FALSE
5	GTEx	Artery Tibial	CYP17A1-AS1	0.08	0.08	lasso	8	0.06	2.8e-05	-6.12	-6.0	1.5e-09	0.36	0.18	0.80	FALSE
6	GTEx	Brain Cortex	CYP17A1-AS1	0.15	0.13	lasso	7	0.14	1.3e-04	-5.59	-5.6	1.8e-08	0.35	0.16	0.50	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	CYP17A1-AS1	0.39	0.22	lasso	3	0.19	8.2e-06	-5.57	-5.1	3.0e-07	0.37	0.21	0.16	FALSE
8	GTEx	Breast Mammary Tissue	CYP17A1-AS1	0.10	-0.01	enet	28	0.00	2.4e-01	-3.92	-6.4	1.6e-10	0.52	0.08	0.60	FALSE
9	GTEx	Breast Mammary Tissue (Female)	CYP17A1-AS1	0.14	0.01	lasso	11	0.00	4.7e-01	-6.75	-7.3	3.2e-13	0.87	0.04	0.57	FALSE
10	GTEx	Cells Transformed fibroblasts	GBF1	0.07	0.00	enet	2	0.00	1.4e-01	-5.25	-5.2	2.1e-07	0.78	0.08	0.07	FALSE
11	GTEx	Cells Transformed fibroblasts	SUFU	0.07	0.04	lasso	3	0.04	3.5e-04	-6.55	-5.4	7.2e-08	0.84	0.38	0.16	FALSE
12	GTEx	Cells Transformed fibroblasts	ARL3	0.07	0.00	enet	13	0.04	1.2e-03	-5.57	5.4	6.2e-08	-0.59	0.04	0.77	FALSE
13	GTEx	Colon Sigmoid	ARL3	0.13	0.10	lasso	6	0.05	5.5e-03	-4.85	5.2	1.9e-07	-0.63	0.13	0.46	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	CYP17A1-AS1	0.23	0.08	enet	23	0.13	1.9e-05	-5.51	-6.3	2.2e-10	0.64	0.16	0.33	FALSE
15	GTEx	Liver	ACTR1A	0.15	0.00	lasso	10	0.00	4.6e-01	0.49	5.6	2.0e-08	-0.25	0.04	0.50	FALSE
16	GTEx	Lung	CYP17A1-AS1	0.06	0.08	lasso	3	0.06	1.6e-05	-5.57	-5.4	7.1e-08	0.37	0.61	0.22	FALSE
17	GTEx	Nerve Tibial	CYP17A1-AS1	0.14	0.08	lasso	6	0.06	7.2e-05	-5.56	-5.7	1.2e-08	0.44	0.48	0.26	FALSE
18	GTEx	Pancreas	CYP17A1-AS1	0.11	0.06	lasso	5	0.06	1.1e-03	-7.60	-6.3	3.1e-10	0.28	0.06	0.56	FALSE
19	GTEx	Testis	NT5C2	0.20	0.03	lasso	8	0.08	2.8e-04	-6.55	-5.8	7.7e-09	0.86	0.05	0.89	FALSE
20	GTEx	Testis	CYP17A1-AS1	0.14	0.08	enet	5	0.10	2.3e-05	-6.91	6.8	1.2e-11	-0.98	0.05	0.93	FALSE
21	GTEx	Thyroid	WBP1L	0.26	0.10	enet	9	0.13	2.1e-10	-3.12	5.6	2.6e-08	-0.81	0.60	0.40	FALSE
22	METSIM	Adipose	AS3MT	0.24	0.28	lasso	12	0.28	6.1e-43	-3.89	5.2	2.5e-07	-0.04	0.96	0.04	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	ARL3	0.24	0.14	bslmm	368	0.16	3.9e-20	-4.85	5.5	3.4e-08	-0.53	1.00	0.00	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	CNNM2	0.11	0.08	lasso	3	0.07	2.2e-09	-7.36	-7.3	2.2e-13	0.99	0.02	0.98	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	CYP17A1-AS1	0.15	0.18	lasso	6	0.19	1.3e-23	-5.59	-6.4	2.0e-10	0.52	1.00	0.00	FALSE
26	YFS	Blood	NT5C2	0.13	0.10	bslmm	382	0.11	7.3e-35	-7.78	-6.2	5.4e-10	0.95	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AS3MT	0.06	0.09	enet	6	0.07	1.3e-06	-7.60	8.4	5.3e-17	-0.69	0.01	0.99	TRUE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	AS3MT	0.05	0.05	enet	10	0.05	4.7e-11	-7.60	6.9	3.7e-12	-0.34	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C10orf32	0.16	0.06	blup	54	0.10	1.3e-05	-3.63	5.3	1.2e-07	-0.11	0.02	0.97	FALSE
30	The Cancer Genome Atlas	Glioblastoma Multiforme	AS3MT	0.15	0.05	blup	62	0.10	5.1e-04	-3.63	5.7	1.2e-08	-0.13	0.02	0.83	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AS3MT	0.05	0.05	blup	62	0.06	1.1e-07	-6.10	5.7	1.1e-08	-0.16	0.02	0.98	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ARL3	0.03	0.02	lasso	3	0.02	1.1e-03	-5.35	5.4	7.1e-08	-0.62	0.01	0.86	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AS3MT	0.04	0.05	enet	3	0.04	8.6e-06	-7.60	7.6	2.3e-14	-0.44	0.00	1.00	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	AS3MT	0.34	0.38	lasso	6	0.38	4.4e-46	-3.63	5.4	6.5e-08	-0.09	0.27	0.73	FALSE
35	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	AS3MT	0.13	0.14	blup	62	0.13	5.6e-06	-6.12	6.3	3.0e-10	-0.27	0.02	0.98	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	AS3MT	0.16	0.21	lasso	9	0.24	2.5e-24	-7.73	5.9	3.1e-09	-0.18	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Rectum Adenocarcinoma	C10orf32	0.17	0.14	blup	52	0.14	3.2e-04	-6.12	6.4	1.4e-10	-0.29	0.02	0.84	FALSE
38	The Cancer Genome Atlas	Thyroid Carcinoma	AS3MT	0.23	0.18	lasso	3	0.18	1.8e-17	-7.73	7.2	4.7e-13	-0.36	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	C10orf26	0.06	0.05	lasso	5	0.04	4.1e-05	-5.51	6.1	1.2e-09	-0.57	0.15	0.74	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	CYP17A1	0.04	0.02	lasso	1	0.02	3.9e-03	-6.10	6.1	1.0e-09	-0.36	0.02	0.72	FALSE