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chr17:37,083,464-39,502,398

Best TWAS P=3.88e-17 · Best GWAS P=7.18e-18 conditioned to 0.0388

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Brain Nucleus accumbens basal ganglia	RAPGEFL1	0.16	0.06	lasso	4	0.07	7.7e-03	8.57	8.4	3.9e-17	0.87	0.02	0.87	TRUE
52	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SMARCE1	0.13	0.11	lasso	4	0.11	2.6e-05	-5.38	-5.6	2.6e-08	-0.05	0.01	0.99	TRUE
51	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GSDMB	0.14	0.16	lasso	4	0.14	2.4e-06	8.52	-7.7	1.0e-14	-0.99	0.00	1.00	FALSE
21	GTEx	Whole Blood	GSDMB	0.15	0.10	lasso	4	0.10	4.5e-09	-7.48	-7.6	2.8e-14	-0.94	0.22	0.78	FALSE
11	GTEx	Heart Atrial Appendage	PNMT	0.14	-0.01	lasso	8	0.00	5.3e-01	8.57	-7.6	3.2e-14	-0.85	0.03	0.87	FALSE
57	The Cancer Genome Atlas	Rectum Adenocarcinoma	GSDMB	0.14	0.09	blup	39	0.17	7.0e-05	7.57	-7.4	1.2e-13	-0.93	0.02	0.91	FALSE
47	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GSDMB	0.02	0.01	blup	39	0.01	1.5e-02	-5.81	-7.3	2.0e-13	-0.97	0.02	0.81	FALSE
33	The Cancer Genome Atlas	Colon Adenocarcinoma	GSDMB	0.10	0.15	blup	40	0.14	1.2e-08	8.61	-7.2	4.9e-13	-0.95	0.01	0.99	FALSE
48	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ORMDL3	0.03	0.04	lasso	2	0.04	2.9e-05	8.15	-7.2	4.9e-13	-0.96	0.04	0.95	FALSE
60	The Cancer Genome Atlas	Stomach Adenocarcinoma	GSDMB	0.06	0.08	enet	7	0.08	1.1e-06	-5.82	-7.2	7.1e-13	-0.95	0.03	0.97	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ORMDL3	0.01	0.01	blup	36	0.00	8.5e-02	8.61	-7.2	7.4e-13	-0.94	0.01	0.83	FALSE
5	GTEx	Colon Transverse	GSDMB	0.14	0.11	enet	18	0.12	2.0e-06	8.02	-7.1	9.7e-13	-0.91	0.16	0.84	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	ORMDL3	0.08	0.13	blup	37	0.15	3.8e-14	-5.77	-7.0	1.9e-12	-0.90	0.66	0.34	FALSE
25	NTR	Blood	GSDMB	0.09	0.10	enet	16	0.12	3.8e-36	-7.37	-7.0	2.1e-12	-0.88	0.65	0.35	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	GSDMB	0.08	0.08	blup	40	0.09	6.6e-09	-5.88	-7.0	2.6e-12	-0.84	0.10	0.90	FALSE
22	GTEx	Whole Blood	ORMDL3	0.18	0.12	lasso	5	0.14	1.8e-12	-5.77	-6.9	4.9e-12	-0.93	0.07	0.93	FALSE
27	NTR	Blood	ORMDL3	0.10	0.10	enet	24	0.12	4.4e-36	8.52	-6.9	5.7e-12	-0.91	0.01	0.99	FALSE
26	NTR	Blood	IKZF3	0.04	0.03	blup	319	0.02	1.5e-08	8.54	6.9	6.3e-12	0.89	0.01	0.99	FALSE
29	YFS	Blood	GSDMB	0.36	0.41	lasso	12	0.49	4.0e-186	-7.54	-6.8	1.0e-11	-0.91	0.95	0.05	FALSE
17	GTEx	Skin Sun Exposed Lower leg	ERBB2	0.10	0.01	enet	8	0.01	3.5e-02	-4.42	-6.7	1.9e-11	-0.77	0.04	0.89	FALSE
30	YFS	Blood	ORMDL3	0.31	0.36	lasso	9	0.45	2.2e-165	-7.54	-6.7	2.3e-11	-0.88	0.96	0.04	FALSE
19	GTEx	Spleen	ORMDL3	0.40	0.44	enet	11	0.39	5.7e-11	-5.86	-6.5	5.8e-11	-0.88	0.64	0.36	FALSE
6	GTEx	Esophagus Mucosa	GSDMB	0.06	0.04	lasso	3	0.03	4.7e-03	-5.58	-6.4	1.8e-10	-0.69	0.16	0.39	FALSE
59	The Cancer Genome Atlas	Skin Cutaneous Melanoma	GSDMA	0.23	0.16	blup	47	0.18	1.3e-05	-6.01	6.3	2.7e-10	0.61	0.02	0.91	FALSE
4	GTEx	Breast Mammary Tissue	ORMDL3	0.17	0.04	enet	27	0.06	7.2e-04	6.77	6.3	2.9e-10	0.78	0.03	0.94	FALSE
18	GTEx	Spleen	GSDMB	0.50	0.45	enet	14	0.43	1.9e-12	-5.86	-6.3	3.0e-10	-0.87	0.69	0.31	FALSE
45	The Cancer Genome Atlas	Lung Adenocarcinoma	GSDMB	0.05	0.07	blup	39	0.05	1.4e-06	-5.81	-6.3	3.0e-10	-0.86	0.50	0.50	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	C17orf37	0.04	0.01	enet	3	0.01	2.3e-02	-2.91	6.3	3.2e-10	0.62	0.01	0.50	FALSE
61	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZPBP2	0.08	0.09	enet	5	0.10	6.1e-08	-7.22	6.2	4.2e-10	0.89	0.46	0.54	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GSDMA	0.15	0.19	enet	9	0.19	1.7e-21	-6.01	6.2	4.9e-10	0.55	0.98	0.02	FALSE
23	METSIM	Adipose	GSDMA	0.14	0.16	lasso	7	0.17	2.6e-24	-5.58	6.2	7.5e-10	0.60	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	GSDMB	0.06	0.05	enet	7	0.05	2.2e-06	-5.88	-6.1	8.0e-10	-0.87	0.47	0.50	FALSE
58	The Cancer Genome Atlas	Soft Tissue Sarcoma	GSDMA	0.44	0.45	lasso	4	0.44	3.2e-28	-6.01	6.1	9.9e-10	0.51	0.98	0.02	FALSE
31	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	GSDMA	0.05	0.06	lasso	4	0.05	7.8e-05	-6.01	6.1	1.2e-09	0.54	0.20	0.27	FALSE
43	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	GSDMA	0.41	0.37	lasso	2	0.38	3.7e-19	-6.01	6.1	1.3e-09	0.54	0.98	0.02	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CASC3	0.08	0.00	bslmm	319	0.01	1.2e-02	4.28	-6.0	1.7e-09	-0.34	0.13	0.05	FALSE
38	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GSDMA	0.37	0.44	lasso	1	0.44	3.3e-27	-6.01	6.0	1.8e-09	0.50	0.98	0.02	FALSE
50	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GSDMA	0.23	0.29	enet	6	0.24	2.8e-10	-6.01	6.0	2.1e-09	0.49	0.96	0.04	FALSE
44	The Cancer Genome Atlas	Lung Adenocarcinoma	GSDMA	0.30	0.35	lasso	4	0.35	6.3e-43	-6.01	5.9	3.9e-09	0.46	0.98	0.02	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	GSDMA	0.19	0.21	lasso	4	0.24	5.5e-23	-6.01	5.8	6.3e-09	0.54	0.98	0.02	FALSE
24	METSIM	Adipose	RP11-387H17.4	0.04	0.00	bslmm	286	0.01	8.4e-03	-0.28	5.8	7.1e-09	0.71	0.03	0.67	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	GSDMA	0.61	0.49	lasso	5	0.51	5.0e-124	-6.01	5.8	7.5e-09	0.50	0.98	0.02	FALSE
7	GTEx	Esophagus Mucosa	ORMDL3	0.09	0.01	enet	20	0.00	1.8e-01	-5.04	-5.7	9.1e-09	-0.53	0.10	0.15	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	GSDMA	0.65	0.56	lasso	4	0.58	1.5e-81	-6.01	5.7	9.2e-09	0.49	0.98	0.02	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	GSDMA	0.16	0.12	lasso	2	0.12	1.1e-12	-6.01	5.7	9.2e-09	0.48	0.98	0.02	FALSE
9	GTEx	Heart Atrial Appendage	PPP1R1B	0.09	0.04	enet	10	0.08	2.2e-04	-5.30	-5.7	1.3e-08	-0.74	0.18	0.68	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GSDMA	0.66	0.48	enet	21	0.51	1.2e-65	-6.01	5.7	1.5e-08	0.49	0.98	0.02	FALSE
62	The Cancer Genome Atlas	Testicular Germ Cell Tumors	GSDMA	0.38	0.32	enet	7	0.32	5.9e-12	-6.01	5.6	2.0e-08	0.50	0.98	0.02	FALSE
20	GTEx	Thyroid	PGAP3	0.19	0.21	lasso	10	0.24	3.5e-18	-4.68	-5.5	4.0e-08	-0.61	1.00	0.00	FALSE
10	GTEx	Heart Atrial Appendage	ERBB2	0.13	0.04	enet	18	0.02	4.8e-02	-3.54	-5.5	4.1e-08	-0.66	0.11	0.60	FALSE
53	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	GSDMA	0.52	0.34	lasso	4	0.36	5.1e-15	-6.01	5.4	5.5e-08	0.46	0.98	0.02	FALSE
34	The Cancer Genome Atlas	Glioblastoma Multiforme	GSDMA	0.58	0.33	enet	10	0.34	5.3e-11	-6.01	5.4	6.6e-08	0.47	0.97	0.02	FALSE
12	GTEx	Liver	PGAP3	0.27	0.17	lasso	4	0.13	1.7e-04	-4.44	-5.4	7.1e-08	-0.59	0.31	0.57	FALSE
39	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PGAP3	0.16	0.16	enet	14	0.15	5.1e-09	-4.44	-5.4	8.3e-08	-0.49	0.02	0.97	FALSE
49	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GSDMA	0.50	0.37	enet	15	0.43	4.2e-31	-6.01	5.4	8.4e-08	0.45	0.98	0.02	FALSE
15	GTEx	Pancreas	PGAP3	0.37	0.25	lasso	6	0.21	1.9e-09	-4.44	-5.3	1.0e-07	-0.61	0.43	0.57	FALSE
13	GTEx	Lung	GSDMB	0.07	0.07	lasso	4	0.05	1.5e-04	-5.77	-5.3	1.2e-07	-0.81	0.44	0.28	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	KRT222	0.02	0.01	lasso	5	0.01	6.8e-02	-4.84	5.3	1.3e-07	0.03	0.01	0.81	FALSE
14	GTEx	Lung	CASC3	0.10	0.00	enet	47	0.02	2.2e-02	1.48	-5.3	1.4e-07	-0.35	0.05	0.41	FALSE
2	GTEx	Adipose Subcutaneous	KRT222	0.11	0.09	lasso	4	0.10	1.3e-08	-4.85	5.3	1.5e-07	0.05	0.05	0.95	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	KRT222	0.06	0.04	enet	7	0.06	9.7e-07	-4.85	5.3	1.5e-07	0.06	0.02	0.98	FALSE
54	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PGAP3	0.17	0.13	blup	41	0.10	6.8e-05	-4.79	-5.2	1.9e-07	-0.58	0.01	0.97	FALSE
16	GTEx	Prostate	PGAP3	0.23	0.03	enet	26	0.06	1.6e-02	-3.60	-5.2	2.1e-07	-0.53	0.14	0.41	FALSE
28	NTR	Blood	SMARCE1	0.04	0.03	lasso	4	0.04	6.5e-13	-5.38	-5.2	2.1e-07	-0.06	0.01	0.99	FALSE
8	GTEx	Esophagus Mucosa	KRT222	0.18	0.12	enet	8	0.12	1.1e-08	-5.38	5.1	2.9e-07	0.07	0.01	0.99	FALSE