[Hub]/) : Traits : Pulse rate, automated reading : ←

chr22:38,192,452-40,338,284

Best TWAS P=2.51e-20 · Best GWAS P=2.86e-20 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
35	GTEx	Esophagus Mucosa	SUN2	0.12	0.14	lasso	3	0.14	1.3e-09	-9.22	9.2	2.5e-20	-0.98	0.01	0.99	TRUE
68	GTEx	Testis	GTPBP1	0.13	0.12	lasso	8	0.17	4.3e-08	-9.10	8.9	8.1e-19	-0.93	0.03	0.97	TRUE
69	GTEx	Testis	AL021707.1	0.12	0.02	lasso	4	0.05	3.4e-03	-7.92	8.3	1.0e-16	-0.92	0.04	0.81	TRUE
84	The Cancer Genome Atlas	Colon Adenocarcinoma	CBY1	0.07	0.11	enet	18	0.10	1.2e-06	-7.90	-8.0	9.7e-16	0.91	0.19	0.81	TRUE
12	GTEx	Artery Aorta	RP3-508I15.9	0.24	0.20	enet	33	0.20	3.0e-11	-7.92	7.5	4.7e-14	-0.83	0.26	0.74	TRUE
87	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CBX6	0.06	0.02	blup	23	0.04	8.7e-06	-4.61	5.3	1.2e-07	-0.24	0.01	0.98	TRUE
37	GTEx	Esophagus Mucosa	RP3-508I15.19	0.08	0.06	lasso	1	0.06	1.1e-04	-9.22	9.2	2.9e-20	-1.00	0.01	0.99	FALSE
32	GTEx	Esophagus Gastroesophageal Junction	RP3-508I15.9	0.12	0.12	lasso	2	0.09	3.2e-04	-9.22	9.2	3.5e-20	-1.00	0.01	0.97	FALSE
94	The Cancer Genome Atlas	Lung Adenocarcinoma	GTPBP1	0.02	0.04	lasso	3	0.03	2.5e-04	-9.22	9.2	4.1e-20	-1.00	0.01	0.97	FALSE
64	GTEx	Skin Sun Exposed Lower leg	RP3-508I15.14	0.06	0.06	lasso	3	0.04	3.3e-04	-9.22	9.1	6.4e-20	-1.00	0.01	0.99	FALSE
45	GTEx	Nerve Tibial	DDX17	0.10	0.09	lasso	5	0.07	1.2e-05	-9.10	-9.1	7.5e-20	0.99	0.01	0.99	FALSE
62	GTEx	Skin Sun Exposed Lower leg	SUN2	0.06	0.06	lasso	3	0.05	5.3e-05	-9.22	9.1	8.1e-20	-0.98	0.00	0.99	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TOMM22	0.15	0.26	lasso	7	0.27	4.0e-33	-9.05	9.1	1.1e-19	-0.95	0.02	0.98	FALSE
70	GTEx	Testis	RP3-508I15.9	0.13	0.11	lasso	4	0.13	1.6e-06	-9.22	9.1	1.2e-19	-0.98	0.02	0.98	FALSE
6	GTEx	Adipose Subcutaneous	TOMM22	0.11	0.02	lasso	5	0.01	6.5e-02	-9.05	9.1	1.3e-19	-0.93	0.02	0.82	FALSE
22	GTEx	Breast Mammary Tissue	CBY1	0.11	0.08	lasso	6	0.07	1.5e-04	-9.10	9.1	1.3e-19	-0.98	0.04	0.96	FALSE
60	GTEx	Skin Sun Exposed Lower leg	TOMM22	0.07	0.07	lasso	4	0.07	3.2e-06	-9.05	9.0	1.4e-19	-0.95	0.02	0.98	FALSE
73	GTEx	Uterus	RP3-508I15.9	0.15	0.09	lasso	4	0.09	8.2e-03	-9.05	9.0	1.7e-19	-0.95	0.04	0.81	FALSE
17	GTEx	Artery Tibial	RP3-508I15.9	0.18	0.21	lasso	8	0.21	1.3e-16	-8.86	9.0	1.8e-19	-0.97	0.04	0.96	FALSE
15	GTEx	Artery Tibial	CBY1	0.23	0.28	lasso	6	0.26	1.9e-20	-8.85	9.0	1.9e-19	-0.97	0.05	0.95	FALSE
92	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC646851	0.13	0.11	enet	18	0.12	2.9e-13	-8.86	-9.0	2.0e-19	0.88	0.01	0.99	FALSE
13	GTEx	Artery Coronary	CBY1	0.26	0.20	lasso	4	0.22	8.3e-08	-8.84	9.0	2.8e-19	-0.96	0.06	0.94	FALSE
42	GTEx	Lung	RP3-508I15.9	0.10	0.15	lasso	2	0.14	1.5e-10	-8.85	8.9	4.5e-19	-0.95	0.04	0.96	FALSE
47	GTEx	Nerve Tibial	TOMM22	0.11	0.08	lasso	4	0.08	5.2e-06	-9.10	8.9	5.4e-19	-0.95	0.02	0.97	FALSE
98	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TOMM22	0.07	0.03	blup	43	0.04	8.8e-03	-9.05	8.9	5.8e-19	-0.95	0.01	0.85	FALSE
34	GTEx	Esophagus Mucosa	JOSD1	0.16	0.24	lasso	2	0.25	1.3e-16	-9.22	8.9	6.1e-19	-0.99	0.01	0.99	FALSE
104	The Cancer Genome Atlas	Thyroid Carcinoma	TOMM22	0.06	0.04	lasso	3	0.04	1.1e-04	-9.05	8.9	6.3e-19	-0.94	0.01	0.98	FALSE
85	The Cancer Genome Atlas	Colon Adenocarcinoma	JOSD1	0.05	0.02	blup	50	0.04	2.7e-03	-8.26	8.9	6.7e-19	-0.95	0.03	0.86	FALSE
66	GTEx	Skin Sun Exposed Lower leg	RP3-508I15.19	0.05	0.04	lasso	2	0.04	4.9e-04	-9.22	8.9	6.8e-19	-0.95	0.01	0.99	FALSE
39	GTEx	Esophagus Muscularis	CBY1	0.15	0.16	lasso	2	0.14	1.2e-08	-8.85	8.9	8.5e-19	-0.94	0.03	0.97	FALSE
96	The Cancer Genome Atlas	Lung Adenocarcinoma	TOMM22	0.02	0.02	blup	43	0.02	1.7e-03	-9.05	8.8	8.9e-19	-0.95	0.01	0.92	FALSE
52	GTEx	Skin Not Sun Exposed Suprapubic	TOMM22	0.13	0.11	lasso	6	0.11	7.9e-07	-9.22	8.8	1.3e-18	-0.98	0.01	0.99	FALSE
8	GTEx	Adipose Visceral Omentum	CBY1	0.15	0.22	lasso	4	0.21	3.4e-11	-8.86	8.8	1.4e-18	-0.95	0.06	0.94	FALSE
7	GTEx	Adipose Subcutaneous	RP3-508I15.9	0.16	0.23	lasso	3	0.22	3.5e-18	-8.84	8.8	1.6e-18	-0.95	0.09	0.91	FALSE
51	GTEx	Pancreas	TOMM22	0.10	0.08	lasso	6	0.09	1.4e-04	-9.05	8.8	1.7e-18	-0.94	0.02	0.97	FALSE
11	GTEx	Artery Aorta	CBY1	0.30	0.24	lasso	5	0.25	4.8e-14	-7.92	8.8	2.1e-18	-0.97	0.05	0.95	FALSE
95	The Cancer Genome Atlas	Lung Adenocarcinoma	JOSD1	0.04	0.05	lasso	4	0.05	7.4e-07	-9.08	8.7	2.4e-18	-0.98	0.01	0.99	FALSE
36	GTEx	Esophagus Mucosa	RP3-508I15.14	0.11	0.08	lasso	7	0.07	2.1e-05	-8.05	8.7	2.9e-18	-0.95	0.06	0.94	FALSE
76	GTEx	Whole Blood	DDX17	0.05	0.00	lasso	4	0.00	4.1e-01	-6.78	-8.6	5.4e-18	0.92	0.03	0.78	FALSE
9	GTEx	Adipose Visceral Omentum	RP3-508I15.9	0.15	0.14	lasso	4	0.14	1.5e-07	-8.86	8.6	5.5e-18	-0.94	0.09	0.91	FALSE
40	GTEx	Esophagus Muscularis	RP3-508I15.9	0.13	0.12	enet	23	0.10	1.1e-06	-8.84	8.6	8.5e-18	-0.93	0.08	0.92	FALSE
46	GTEx	Nerve Tibial	CBY1	0.22	0.32	lasso	11	0.34	1.0e-24	-8.84	8.6	9.8e-18	-0.94	0.21	0.79	FALSE
10	GTEx	Artery Aorta	DDX17	0.07	0.03	lasso	4	0.04	2.1e-03	-8.12	-8.5	1.6e-17	0.96	0.03	0.93	FALSE
30	GTEx	Colon Sigmoid	RP3-508I15.9	0.10	0.11	lasso	15	0.09	5.8e-04	-8.86	8.5	1.9e-17	-0.94	0.09	0.88	FALSE
24	GTEx	Breast Mammary Tissue (Female)	CBY1	0.13	0.03	lasso	2	0.00	3.0e-01	-7.70	8.5	2.3e-17	-0.90	0.04	0.67	FALSE
105	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	LOC646851	0.16	0.05	lasso	9	0.04	2.7e-02	-8.06	-8.5	2.5e-17	0.83	0.01	0.50	FALSE
20	GTEx	Brain Cortex	RP3-508I15.9	0.21	0.12	lasso	7	0.10	1.1e-03	-8.12	8.5	2.6e-17	-0.95	0.10	0.83	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CBY1	0.04	0.02	blup	377	0.03	1.5e-04	-9.22	8.4	3.2e-17	-0.88	0.02	0.98	FALSE
5	GTEx	Adipose Subcutaneous	CBY1	0.21	0.22	lasso	5	0.23	1.5e-18	-8.85	8.4	3.2e-17	-0.94	0.24	0.76	FALSE
48	GTEx	Nerve Tibial	RP3-508I15.9	0.26	0.38	lasso	10	0.40	5.6e-30	-7.89	8.4	4.4e-17	-0.93	0.53	0.47	FALSE
97	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LOC646851	0.08	0.06	blup	47	0.07	8.1e-04	-7.14	-8.4	4.5e-17	0.93	0.03	0.91	FALSE
65	GTEx	Skin Sun Exposed Lower leg	RP3-508I15.9	0.22	0.28	lasso	10	0.30	1.6e-25	-8.02	8.4	4.7e-17	-0.93	0.53	0.47	FALSE
16	GTEx	Artery Tibial	TOMM22	0.07	0.10	lasso	3	0.09	8.2e-08	-8.01	8.4	5.1e-17	-0.85	0.14	0.85	FALSE
75	GTEx	Vagina	RP3-508I15.9	0.29	0.21	lasso	4	0.14	3.8e-04	-8.86	8.4	5.2e-17	-0.91	0.06	0.88	FALSE
44	GTEx	Muscle Skeletal	TOMM22	0.03	0.02	lasso	4	0.01	2.2e-02	-8.01	8.4	6.3e-17	-0.92	0.09	0.84	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DDX17	0.04	0.02	lasso	6	0.03	1.2e-04	-6.15	-8.3	7.8e-17	0.89	0.04	0.95	FALSE
78	NTR	Blood	SUN2	0.03	0.02	bslmm	388	0.03	4.3e-09	-6.16	-8.3	8.2e-17	0.72	0.93	0.07	FALSE
3	CommonMind	Brain Pre-frontal Cortex	JOSD1	0.06	0.06	lasso	2	0.07	1.3e-08	-7.91	8.3	9.2e-17	-0.92	0.18	0.82	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	RP3-508I15.9	0.17	0.17	lasso	3	0.17	1.4e-09	-7.91	8.3	1.1e-16	-0.93	0.17	0.83	FALSE
59	GTEx	Skin Sun Exposed Lower leg	CBY1	0.11	0.13	enet	22	0.12	2.1e-10	-8.84	8.3	1.5e-16	-0.91	0.03	0.97	FALSE
71	GTEx	Thyroid	TOMM22	0.06	0.09	lasso	1	0.07	9.8e-06	-8.26	8.3	1.5e-16	-0.87	0.03	0.96	FALSE
14	GTEx	Artery Coronary	RP3-508I15.9	0.22	0.24	lasso	4	0.24	1.6e-08	-7.92	8.2	2.6e-16	-0.92	0.15	0.85	FALSE
61	GTEx	Skin Sun Exposed Lower leg	JOSD1	0.09	0.15	lasso	2	0.14	1.7e-11	-8.05	8.1	6.2e-16	-0.91	0.58	0.42	FALSE
27	GTEx	Cells Transformed fibroblasts	CBY1	0.30	0.47	lasso	2	0.47	7.7e-39	-7.92	8.0	9.9e-16	-0.91	0.98	0.02	FALSE
86	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	JOSD1	0.08	0.03	enet	5	0.04	3.4e-05	-7.51	8.0	1.0e-15	-0.85	0.10	0.87	FALSE
53	GTEx	Skin Not Sun Exposed Suprapubic	JOSD1	0.12	0.13	lasso	4	0.12	4.9e-07	-7.92	8.0	1.1e-15	-0.91	0.39	0.60	FALSE
89	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC646851	0.02	0.03	lasso	1	0.02	1.2e-03	-8.02	-8.0	1.1e-15	0.90	0.03	0.75	FALSE
80	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	JOSD1	0.02	0.01	blup	49	0.02	1.4e-02	-8.05	8.0	1.2e-15	-0.92	0.03	0.59	FALSE
29	GTEx	Cells Transformed fibroblasts	RP3-508I15.9	0.31	0.43	lasso	15	0.43	6.2e-35	-7.92	8.0	1.5e-15	-0.92	0.97	0.03	FALSE
83	The Cancer Genome Atlas	Breast Invasive Carcinoma	TOMM22	0.02	0.01	enet	11	0.01	1.1e-03	-8.99	7.9	2.6e-15	-0.87	0.01	0.97	FALSE
72	GTEx	Thyroid	RP3-508I15.22	0.09	0.09	lasso	6	0.09	4.1e-07	-7.59	-7.8	4.2e-15	0.78	0.19	0.79	FALSE
49	GTEx	Ovary	CBY1	0.23	0.22	lasso	13	0.20	9.9e-06	-7.77	7.8	5.6e-15	-0.87	0.12	0.81	FALSE
23	GTEx	Breast Mammary Tissue	RP3-508I15.9	0.11	0.14	lasso	3	0.13	3.6e-07	-7.67	7.8	5.9e-15	-0.93	0.31	0.69	FALSE
50	GTEx	Ovary	RP3-508I15.9	0.19	0.28	lasso	2	0.24	1.1e-06	-7.77	7.8	7.3e-15	-0.83	0.08	0.89	FALSE
58	GTEx	Skin Sun Exposed Lower leg	DDX17	0.05	0.04	lasso	4	0.02	4.7e-03	-7.75	-7.8	7.8e-15	0.87	0.49	0.46	FALSE
25	GTEx	Breast Mammary Tissue (Female)	RP3-508I15.9	0.13	0.12	lasso	3	0.07	3.6e-03	-7.75	7.8	8.9e-15	-0.86	0.09	0.46	FALSE
100	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC646851	0.03	0.03	blup	48	0.03	2.7e-04	-7.14	-7.7	1.1e-14	0.89	0.06	0.87	FALSE
43	GTEx	Lung	RP3-508I15.22	0.05	0.04	lasso	1	0.03	1.8e-03	-7.70	-7.7	1.4e-14	0.80	0.18	0.43	FALSE
90	The Cancer Genome Atlas	Brain Lower Grade Glioma	GTPBP1	0.02	0.02	blup	57	0.02	8.6e-04	-7.14	7.6	2.5e-14	-0.85	0.07	0.58	FALSE
18	GTEx	Artery Tibial	RP3-508I15.22	0.06	0.00	enet	23	0.00	6.5e-01	-8.13	-7.6	2.8e-14	0.72	0.06	0.78	FALSE
41	GTEx	Lung	TOMM22	0.05	0.04	enet	11	0.04	3.8e-04	-7.14	7.5	7.4e-14	-0.86	0.06	0.91	FALSE
81	The Cancer Genome Atlas	Breast Invasive Carcinoma	JOSD1	0.02	0.01	lasso	3	0.02	2.0e-05	5.37	7.5	7.8e-14	-0.84	0.04	0.96	FALSE
77	NTR	Blood	DDX17	0.02	0.03	lasso	3	0.03	8.8e-10	-6.84	-7.4	9.8e-14	0.83	0.90	0.10	FALSE
56	GTEx	Skin Not Sun Exposed Suprapubic	RP3-508I15.19	0.14	0.06	enet	39	0.03	7.8e-03	-8.02	7.3	2.5e-13	-0.76	0.10	0.83	FALSE
99	The Cancer Genome Atlas	Prostate Adenocarcinoma	CBY1	0.03	0.01	blup	40	0.02	4.2e-03	-8.13	-7.3	3.6e-13	0.86	0.04	0.70	FALSE
103	The Cancer Genome Atlas	Thyroid Carcinoma	LOC646851	0.02	0.03	lasso	3	0.01	1.4e-02	-7.14	-7.3	4.1e-13	0.87	0.02	0.80	FALSE
38	GTEx	Esophagus Muscularis	DDX17	0.08	0.10	lasso	1	0.07	3.9e-05	-7.14	-7.1	9.6e-13	0.86	0.16	0.82	FALSE
93	The Cancer Genome Atlas	Lung Adenocarcinoma	DNAL4	0.03	0.01	blup	46	0.00	1.6e-01	3.03	7.1	1.1e-12	-0.67	0.02	0.34	FALSE
82	The Cancer Genome Atlas	Breast Invasive Carcinoma	SUN2	0.01	0.00	blup	60	0.00	1.4e-01	3.03	7.1	1.5e-12	-0.74	0.02	0.18	FALSE
26	GTEx	Cells EBV-transformed lymphocytes	JOSD1	0.12	0.12	lasso	7	0.07	2.0e-03	-7.14	7.1	1.7e-12	-0.87	0.13	0.67	FALSE
57	GTEx	Skin Not Sun Exposed Suprapubic	RP3-508I15.22	0.08	0.00	lasso	5	0.01	6.0e-02	-3.67	-7.0	2.0e-12	0.79	0.03	0.90	FALSE
31	GTEx	Esophagus Gastroesophageal Junction	CBY1	0.14	0.03	lasso	2	0.05	8.4e-03	4.19	7.0	3.0e-12	-0.67	0.04	0.79	FALSE
67	GTEx	Testis	TOMM22	0.10	0.00	enet	23	0.01	8.4e-02	-7.70	6.5	6.3e-11	-0.56	0.04	0.64	FALSE
101	The Cancer Genome Atlas	Stomach Adenocarcinoma	LOC646851	0.04	0.03	enet	10	0.04	1.1e-03	-8.02	-6.4	1.6e-10	0.70	0.02	0.69	FALSE
79	YFS	Blood	JOSD1	0.03	0.03	bslmm	347	0.03	1.9e-10	-7.89	6.4	1.9e-10	-0.77	0.19	0.81	FALSE
28	GTEx	Cells Transformed fibroblasts	JOSD1	0.07	0.02	enet	4	0.03	3.1e-03	-5.93	6.2	5.3e-10	-0.48	0.12	0.48	FALSE
88	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DNAL4	0.04	0.02	blup	46	0.03	1.1e-04	4.19	6.2	7.5e-10	-0.57	0.06	0.15	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	SUN2	0.13	0.00	enet	36	0.02	2.9e-02	-8.02	6.1	8.4e-10	-0.71	0.13	0.74	FALSE
33	GTEx	Esophagus Mucosa	TOMM22	0.10	0.02	enet	20	0.02	3.2e-02	-8.63	5.8	5.3e-09	-0.53	0.03	0.69	FALSE
19	GTEx	Brain Cerebellar Hemisphere	TOMM22	0.37	-0.01	lasso	11	-0.01	6.5e-01	-6.21	5.8	8.3e-09	-0.57	0.05	0.29	FALSE
21	GTEx	Brain Putamen basal ganglia	RP3-508I15.9	0.23	0.00	enet	9	0.05	2.6e-02	-6.78	5.5	2.9e-08	-0.66	0.06	0.41	FALSE
74	GTEx	Vagina	RP3-508I15.14	0.33	-0.01	lasso	5	0.02	1.4e-01	1.09	5.5	3.2e-08	-0.52	0.04	0.33	FALSE
91	The Cancer Genome Atlas	Brain Lower Grade Glioma	KDELR3	0.07	0.03	blup	49	0.02	8.2e-04	0.01	-5.3	1.1e-07	0.42	0.04	0.39	FALSE
63	GTEx	Skin Sun Exposed Lower leg	PDGFB	0.11	0.00	enet	22	0.01	2.2e-02	1.59	-5.2	1.6e-07	0.31	0.06	0.22	FALSE
102	The Cancer Genome Atlas	Thyroid Carcinoma	CBX6	0.13	0.02	enet	3	0.03	5.6e-04	-5.37	5.2	2.4e-07	-0.26	0.00	0.96	FALSE