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chr10:103,527,782-105,897,979

Best TWAS P=1.37e-14 · Best GWAS P=4.32e-13 conditioned to 0.589

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
45	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C10orf32	0.06	0.06	blup	54	0.08	1.2e-07	-6.49	7.7	1.4e-14	-0.74	0.02	0.98	TRUE
69	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMEM180	0.13	0.03	blup	52	0.02	5.7e-02	-4.00	-5.8	5.4e-09	0.21	0.02	0.19	TRUE
24	GTEx	Esophagus Muscularis	SUFU	0.07	0.04	enet	18	0.03	5.2e-03	4.43	7.6	4.1e-14	-0.46	0.26	0.55	FALSE
75	The Cancer Genome Atlas	Rectum Adenocarcinoma	C10orf32	0.17	0.14	blup	52	0.14	3.2e-04	-6.30	7.3	2.6e-13	-0.64	0.04	0.54	FALSE
62	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C10orf32	0.08	0.07	blup	54	0.07	4.2e-04	-6.67	7.3	2.8e-13	-0.71	0.01	0.98	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	C10orf32	0.27	0.27	enet	13	0.29	1.3e-28	-6.49	7.2	4.3e-13	-0.67	0.06	0.94	FALSE
15	GTEx	Brain Cerebellar Hemisphere	NT5C2	0.15	0.10	enet	8	0.07	9.2e-03	-6.48	7.2	4.7e-13	-0.78	0.07	0.52	FALSE
8	GTEx	Adipose Visceral Omentum	NT5C2	0.13	0.07	enet	12	0.08	5.0e-05	-6.13	-7.2	7.3e-13	0.84	0.04	0.95	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C10orf32	0.21	0.21	enet	11	0.25	3.1e-28	-6.67	7.1	9.7e-13	-0.59	0.01	0.99	FALSE
6	GTEx	Adipose Subcutaneous	NT5C2	0.09	0.05	lasso	2	0.04	6.5e-04	-7.02	-7.1	1.5e-12	0.97	0.03	0.97	FALSE
40	NTR	Blood	C10orf32	0.02	0.03	lasso	6	0.02	1.7e-08	-6.70	7.1	1.5e-12	-0.67	0.20	0.80	FALSE
3	CommonMind	Brain Pre-frontal Cortex	AS3MT	0.17	0.16	lasso	9	0.15	4.5e-18	-6.67	7.1	1.6e-12	-0.65	0.23	0.77	FALSE
25	GTEx	Liver	ACTR1A	0.15	0.00	lasso	10	0.00	4.6e-01	3.27	7.1	1.7e-12	-0.52	0.06	0.26	FALSE
23	GTEx	Esophagus Mucosa	SUFU	0.08	0.02	enet	18	0.01	4.2e-02	5.28	7.0	1.8e-12	-0.27	0.59	0.21	FALSE
53	The Cancer Genome Atlas	Glioblastoma Multiforme	C10orf32	0.27	0.09	lasso	8	0.17	7.3e-06	-5.89	7.0	3.5e-12	-0.57	0.08	0.71	FALSE
64	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C10orf32	0.11	0.16	lasso	4	0.15	1.4e-16	-6.49	6.9	4.6e-12	-0.66	0.06	0.94	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	C10orf32	0.18	0.19	lasso	4	0.19	4.1e-19	-6.49	6.9	4.6e-12	-0.67	0.02	0.98	FALSE
34	METSIM	Adipose	ARL3	0.04	0.00	bslmm	364	0.01	1.4e-02	-3.46	-6.9	6.2e-12	0.37	0.13	0.18	FALSE
4	CommonMind	Brain Pre-frontal Cortex	C10orf32	0.43	0.54	bslmm	348	0.54	2.2e-78	-6.49	6.9	6.5e-12	-0.67	0.30	0.70	FALSE
48	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C10orf32	0.16	0.06	blup	54	0.10	1.3e-05	-6.49	6.9	6.8e-12	-0.43	0.02	0.96	FALSE
19	GTEx	Brain Cortex	CYP17A1-AS1	0.15	0.13	lasso	7	0.14	1.3e-04	-5.33	-6.8	7.4e-12	0.43	0.16	0.51	FALSE
63	The Cancer Genome Atlas	Lung Adenocarcinoma	C10orf32	0.14	0.21	enet	12	0.21	5.0e-24	-6.67	6.8	7.6e-12	-0.60	0.09	0.91	FALSE
18	GTEx	Brain Cerebellum	ARL3	0.20	0.09	enet	32	0.07	3.7e-03	-5.33	-6.8	8.9e-12	0.41	0.21	0.51	FALSE
13	GTEx	Artery Tibial	WBP1L	0.07	0.06	lasso	5	0.03	9.7e-04	-6.18	-6.8	9.5e-12	0.62	0.06	0.92	FALSE
35	METSIM	Adipose	AS3MT	0.24	0.28	lasso	12	0.28	6.1e-43	-6.70	6.8	1.1e-11	-0.60	0.20	0.80	FALSE
60	The Cancer Genome Atlas	Brain Lower Grade Glioma	AS3MT	0.34	0.38	lasso	6	0.38	4.4e-46	-6.49	6.8	1.1e-11	-0.63	0.24	0.76	FALSE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	C10orf32	0.21	0.19	lasso	6	0.19	2.2e-21	-6.70	6.8	1.2e-11	-0.66	0.09	0.91	FALSE
51	The Cancer Genome Atlas	Esophageal Carcinoma	C10orf32	0.19	0.25	enet	7	0.23	8.1e-08	-6.70	6.7	1.7e-11	-0.66	0.06	0.94	FALSE
78	The Cancer Genome Atlas	Thyroid Carcinoma	AS3MT	0.23	0.18	lasso	3	0.18	1.8e-17	-6.53	6.7	1.8e-11	-0.60	0.24	0.76	FALSE
67	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	AS3MT	0.15	0.21	lasso	2	0.19	1.4e-08	-6.67	6.7	2.5e-11	-0.68	0.09	0.91	FALSE
77	The Cancer Genome Atlas	Stomach Adenocarcinoma	C10orf32	0.19	0.21	lasso	2	0.20	1.8e-14	-6.49	6.6	4.1e-11	-0.67	0.09	0.91	FALSE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AS3MT	0.04	0.05	enet	3	0.04	8.6e-06	-6.57	6.6	5.3e-11	-0.57	0.15	0.82	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	C10orf32	0.12	0.14	enet	6	0.14	8.2e-27	-6.49	6.6	5.7e-11	-0.67	0.14	0.86	FALSE
71	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C10orf32	0.30	0.29	lasso	3	0.28	1.8e-11	-6.67	6.5	7.7e-11	-0.64	0.07	0.93	FALSE
50	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM180	0.04	0.02	enet	9	0.05	4.2e-04	-5.11	-6.5	7.8e-11	0.23	0.02	0.72	FALSE
65	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C10orf32	0.09	0.10	lasso	2	0.10	2.2e-07	-6.49	6.5	8.3e-11	-0.66	0.10	0.89	FALSE
33	GTEx	Uterus	TMEM180	0.22	0.00	enet	23	0.00	2.6e-01	4.42	6.5	8.4e-11	-0.31	0.06	0.15	FALSE
12	GTEx	Artery Tibial	NT5C2	0.06	0.04	lasso	9	0.02	1.5e-02	-6.30	6.4	1.3e-10	-0.52	0.16	0.57	FALSE
9	GTEx	Adipose Visceral Omentum	WBP1L	0.08	0.00	enet	13	0.01	8.1e-02	-5.20	-6.4	1.4e-10	0.29	0.10	0.34	FALSE
55	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C10orf32	0.18	0.16	enet	9	0.17	8.0e-19	-6.49	6.4	1.4e-10	-0.60	0.11	0.89	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	CYP17A1	0.04	0.02	lasso	1	0.02	3.9e-03	-6.42	6.4	1.4e-10	-0.49	0.06	0.34	FALSE
14	GTEx	Artery Tibial	CYP17A1-AS1	0.08	0.08	lasso	8	0.06	2.8e-05	-6.30	-6.4	1.5e-10	0.53	0.35	0.59	FALSE
26	GTEx	Liver	TMEM180	0.28	0.17	enet	36	0.17	1.7e-05	4.79	6.4	1.6e-10	-0.29	0.68	0.15	FALSE
70	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	AS3MT	0.13	0.14	blup	62	0.13	5.6e-06	-6.30	6.4	1.7e-10	-0.51	0.27	0.71	FALSE
68	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C10orf32	0.36	0.32	enet	10	0.32	8.3e-14	-6.49	6.4	2.0e-10	-0.69	0.09	0.91	FALSE
31	GTEx	Pancreas	CYP17A1-AS1	0.11	0.06	lasso	5	0.06	1.1e-03	-6.57	-6.4	2.2e-10	0.31	0.09	0.38	FALSE
72	The Cancer Genome Atlas	Prostate Adenocarcinoma	AS3MT	0.16	0.21	lasso	9	0.24	2.5e-24	-6.53	6.2	4.4e-10	-0.50	0.20	0.80	FALSE
56	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM180	0.03	0.03	blup	52	0.04	3.9e-05	4.75	-6.2	6.0e-10	0.11	0.03	0.95	FALSE
28	GTEx	Muscle Skeletal	SFXN2	0.07	0.02	lasso	3	0.03	4.6e-04	-6.18	-6.2	6.9e-10	0.50	0.20	0.34	FALSE
11	GTEx	Artery Coronary	CYP17A1-AS1	0.20	-0.01	enet	21	0.04	2.3e-02	-0.48	-6.1	1.1e-09	0.61	0.04	0.43	FALSE
74	The Cancer Genome Atlas	Prostate Adenocarcinoma	NT5C2	0.14	0.13	lasso	5	0.12	4.4e-12	-6.61	6.1	1.1e-09	-0.51	0.11	0.89	FALSE
36	METSIM	Adipose	C10orf32	0.20	0.24	lasso	6	0.26	2.2e-38	-6.70	6.0	2.1e-09	-0.53	0.21	0.79	FALSE
54	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AS3MT	0.05	0.05	blup	62	0.06	1.1e-07	-6.42	6.0	2.2e-09	-0.43	0.15	0.85	FALSE
20	GTEx	Brain Hypothalamus	CYP17A1-AS1	0.34	0.10	lasso	10	0.05	2.6e-02	-4.75	-5.9	3.4e-09	0.36	0.10	0.37	FALSE
17	GTEx	Brain Cerebellum	NT5C2	0.23	0.15	lasso	4	0.09	1.4e-03	-6.48	5.9	3.5e-09	-0.52	0.16	0.46	FALSE
52	The Cancer Genome Atlas	Glioblastoma Multiforme	AS3MT	0.15	0.05	blup	62	0.10	5.1e-04	-6.49	5.8	6.7e-09	-0.42	0.05	0.45	FALSE
7	GTEx	Adipose Subcutaneous	WBP1L	0.05	0.00	enet	8	0.00	5.3e-01	4.77	-5.8	7.4e-09	0.05	0.11	0.13	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	RP11-18I14.11	0.17	0.08	lasso	8	0.09	8.7e-04	4.82	-5.8	7.7e-09	0.17	0.20	0.18	FALSE
16	GTEx	Brain Cerebellar Hemisphere	ARL3	0.15	0.02	enet	18	0.11	1.1e-03	5.65	-5.8	8.1e-09	0.20	0.12	0.08	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	AS3MT	0.44	0.40	enet	15	0.45	2.1e-63	-6.67	5.8	8.6e-09	-0.48	0.26	0.74	FALSE
49	The Cancer Genome Atlas	Colon Adenocarcinoma	C10orf32	0.34	0.25	blup	54	0.32	1.1e-18	-6.49	5.7	9.4e-09	-0.47	0.15	0.85	FALSE
59	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C10orf32	0.36	0.21	blup	54	0.23	1.6e-13	-6.49	5.7	1.1e-08	-0.53	0.03	0.97	FALSE
32	GTEx	Skin Sun Exposed Lower leg	ACTR1A	0.08	0.06	enet	10	0.07	2.7e-06	5.07	-5.6	1.6e-08	0.18	0.91	0.01	FALSE
39	NTR	Blood	AS3MT	0.03	0.01	bslmm	351	0.02	4.4e-06	-6.67	5.6	2.1e-08	-0.56	0.15	0.85	FALSE
10	GTEx	Artery Coronary	TMEM180	0.14	0.05	enet	13	0.04	2.4e-02	4.42	5.6	2.4e-08	-0.18	0.20	0.26	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	AS3MT	0.05	0.05	enet	10	0.05	4.7e-11	-6.57	5.6	2.5e-08	-0.40	0.23	0.77	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ACTR1A	0.03	0.01	blup	347	0.01	5.6e-02	-5.00	-5.5	3.1e-08	0.32	0.14	0.24	FALSE
43	YFS	Blood	TRIM8	0.04	0.04	lasso	6	0.05	1.2e-15	4.77	-5.5	3.1e-08	0.11	1.00	0.00	FALSE
21	GTEx	Brain Nucleus accumbens basal ganglia	CYP17A1-AS1	0.39	0.22	lasso	3	0.19	8.2e-06	-5.25	-5.5	3.8e-08	0.40	0.23	0.09	FALSE
76	The Cancer Genome Atlas	Soft Tissue Sarcoma	C10orf32	0.07	0.03	blup	52	0.03	6.4e-03	-6.49	5.5	4.6e-08	-0.48	0.01	0.88	FALSE
38	NTR	Blood	ACTR1A	0.03	0.03	enet	19	0.03	1.4e-09	4.43	-5.5	5.0e-08	0.14	1.00	0.00	FALSE
29	GTEx	Nerve Tibial	SFXN2	0.30	0.22	lasso	11	0.22	1.7e-15	-4.94	-5.4	7.7e-08	0.28	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SUFU	0.03	0.02	blup	90	0.02	1.5e-02	5.05	5.4	8.7e-08	-0.08	0.06	0.50	FALSE
44	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AS3MT	0.06	0.09	enet	6	0.07	1.3e-06	-6.57	5.3	9.9e-08	-0.42	0.22	0.77	FALSE
5	CommonMind	Brain Pre-frontal Cortex	TMEM180	0.21	0.07	lasso	6	0.14	1.9e-16	-3.99	-5.3	1.0e-07	0.10	1.00	0.00	FALSE
27	GTEx	Lung	CYP17A1-AS1	0.06	0.08	lasso	3	0.06	1.6e-05	-5.25	-5.3	1.2e-07	0.40	0.74	0.07	FALSE
37	METSIM	Adipose	PDCD11	0.04	0.02	bslmm	367	0.02	9.4e-04	4.02	-5.3	1.2e-07	0.37	0.21	0.08	FALSE
30	GTEx	Nerve Tibial	CYP17A1-AS1	0.14	0.08	lasso	6	0.06	7.2e-05	-5.25	-5.2	1.9e-07	0.35	0.58	0.09	FALSE
41	NTR	Blood	TRIM8	0.02	0.01	enet	11	0.01	2.1e-03	4.43	-5.2	2.3e-07	0.11	0.78	0.01	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ARL3	0.03	0.03	lasso	6	0.03	1.8e-04	4.28	-5.1	3.1e-07	0.04	0.90	0.02	FALSE