Hub : Genes

PDCD11

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0367	0.0197	0.00280	0.017	0.017	0.017	0.018	0.013	1.3e-03	1.1e-03	0.00130	0.00094	3.8e-03
2	TCGA	Lung Squamous Cell Carcinoma	0.0370	0.0231	0.00940	0.000	0.010	0.004	NA	-0.001	3.1e-01	2.4e-02	0.11000	NA	4.1e-01
3	TCGA	Prostate Adenocarcinoma	0.0475	0.0237	0.00025	0.036	0.037	0.024	NA	0.026	1.0e-04	8.6e-05	0.00140	NA	8.8e-04
4	TCGA	Thyroid Carcinoma	0.0700	0.0360	0.00057	0.042	0.038	0.038	NA	0.044	5.7e-05	1.3e-04	0.00012	NA	3.7e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.8	1.8	-0.6	-0.9	-0.4	-1.3
Bipolar Disorder or Schizophrenia	1.0	2.5	3.7	0.0	-1.9	-1.8	-1.8
Depressed Affect (Nagel 2018)	0.5	1.1	2.8	0.9	-1.7	-0.8	0.4
Depression (Nagel 2018)	0.9	1.3	2.0	0.7	-1.4	-1.4	-0.8
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.8	-0.5	0.4	1.7	1.5
Neuroticism (Nagel 2018)	1.9	4.4	7.0	1.2	-2.6	-2.6	-1.6
Schizophrenia (2018)	1.0	2.2	3.9	0.5	-1.7	-2.0	-1.2
Schizophrenia vs Biploar Disorder	1.2	1.6	3.5	1.9	-0.6	-1.0	-1.3
Worry (Nagel 2018)	4.1	8.7	13.3	0.4	-3.6	-3.7	-2.9
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.5	-0.1	0.3	0.2
Alzheimer’s Disease (in father)	2.5	2.7	4.3	-1.7	2.1	1.9	0.3
Alzheimer’s Disease (including proxy)	0.6	0.9	2.5	-1.6	0.6	0.8	0.4
Crohns Disease (2017)	0.9	1.9	4.4	0.9	2.1	1.4	0.7
Irritable Bowel Disease (IBD)	1.6	3.8	8.2	-1.2	2.9	2.0	1.3
Ulcerative Colitis (UC)	2.2	4.2	6.7	-2.1	2.6	2.0	1.4
Major Depression (MDD)	0.4	0.5	1.0	0.5	-0.7	-1.0	-0.4
Reaction Time	0.1	0.2	0.3	-0.5	0.3	0.5	0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	0.2	-0.7	-0.2	-0.2
Breast Cancer	0.6	1.5	4.0	-2.0	0.8	0.8	0.8
Ovarian Cancer	0.2	0.3	0.5	-0.4	-0.7	-0.6	-0.4
Prostate Cancer	0.8	1.1	3.3	-0.1	-1.8	-0.9	-0.2
Age at First Birth	2.5	3.6	5.0	-2.2	1.1	2.1	1.9
Bipolar Disorder (2011)	1.2	1.2	1.7	-0.3	-1.2	-1.3	-1.3
Body Mass Index (BMI) (2010)	0.6	0.8	1.9	1.4	0.8	0.7	0.2
Coronary Artery Disease (CAD)	2.4	2.9	7.3	0.7	-1.2	-1.5	-2.7
Crohns Disease (2012)	0.5	0.8	2.0	1.4	0.2	-0.7	-0.9
Mean Putamen Volume	1.7	1.9	2.7	-1.6	1.4	0.8	1.6
Fasting Glucose	2.4	2.8	3.9	-0.5	1.9	2.0	1.9
HbA1C	2.2	2.4	5.1	-0.9	2.3	1.5	1.2
HDL Cholesterol	2.6	4.3	7.5	1.9	-2.7	-2.0	-1.5
LDL Cholesterol	0.2	0.3	0.6	-0.1	-0.7	-0.6	-0.3
Lupus	0.1	0.1	0.5	-0.1	-0.0	-0.3	-0.7
Neuroticism (2016)	1.2	1.7	2.6	-0.8	1.4	1.6	1.2
Primary Biliary Cirrhosis	0.6	0.8	1.1	1.0	-0.8	-0.9	-0.9
Rheumatoid Arthritis	0.4	0.5	1.1	1.1	-0.3	-0.8	-0.1
Schizophrenia (2014)	0.4	0.9	1.9	-0.5	-1.1	-1.4	-0.7
Triglycerides	0.8	1.2	3.3	-1.8	1.3	0.1	0.2
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.6	-0.9	-1.0	-1.2	-0.0
Ulcerative Colitis	0.6	0.8	1.5	-1.2	1.2	0.3	0.6
Blood Eosinophil Count	0.4	3.0	10.4	-3.2	0.1	-0.9	0.8
Blood Platelet Count	0.2	1.9	4.6	1.7	2.1	0.2	0.1
Blood Red Count	0.4	4.3	10.0	-3.2	2.4	1.0	0.7
Blood White Count	0.4	2.7	6.1	2.5	1.6	-1.3	-0.5
Heel T-Score	0.4	3.4	13.5	-3.7	0.0	0.3	-0.1
BMI	0.2	0.9	1.8	-0.2	1.0	1.0	1.3
Height	0.1	1.1	4.1	2.0	0.3	-0.2	0.1
Waist Hip Ratio (WHR)	0.3	1.3	4.9	2.2	0.2	0.2	0.3
Systolic Blood Pressure	1.7	8.3	17.4	1.0	-1.7	-3.4	-4.2
Smoking Status	4.4	10.4	39.7	6.3	1.0	0.4	1.0
Allergy or Eczema	1.9	5.0	12.8	-3.6	-1.8	-1.3	-1.4
Cardiovascular Disease	0.2	0.8	1.4	-0.6	1.2	-0.6	-1.0
Hypothyroidism (self reported)	0.8	1.9	3.9	0.0	2.0	1.1	1.6
Respiratory disease	0.9	2.1	7.3	-2.7	0.4	0.3	0.8
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.4	0.7	1.2	1.0	0.3
Lung FEV1/FVC ratio	0.6	3.0	10.2	3.2	0.2	-0.8	-1.1
Lung FVC	0.7	3.7	10.1	3.2	-0.7	-1.8	-1.0
Neuroticism	2.9	7.1	11.0	1.3	-3.3	-3.2	-2.3
Chronotype (morning person)	0.2	0.4	1.3	-0.4	-0.3	1.1	0.2
Hair Pigment	0.0	0.7	1.5	-0.5	-1.2	-1.1	-0.2
Tanning	0.6	6.8	16.5	4.1	-2.3	-2.1	-1.0
Hand grip strength (left)	0.5	1.4	3.6	1.9	0.0	-0.9	-1.1
Number of treatments/medications taken	0.3	0.6	2.0	0.5	1.4	0.2	-0.2
Average weekly spirits intake	3.1	3.9	7.0	1.6	-1.4	-2.0	-2.7
Sensitivity / hurt feelings	0.6	1.0	1.4	0.5	-1.2	-1.1	-1.0
Frequency of depressed mood in last 2 weeks	1.3	1.8	3.8	0.6	-1.9	-1.7	-0.7
Hearing difficulty/problems: Yes	1.1	1.6	2.4	1.6	1.0	1.2	1.3
Relative age of first facial hair	0.7	1.4	2.3	1.5	-0.7	-1.2	-1.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.4	-0.5	-0.5	-0.8	-1.2
Ever used hormone-replacement therapy (HRT)	0.9	1.2	4.1	-2.0	0.5	0.3	0.5
Ever had hysterectomy (womb removed)	0.2	0.2	0.8	-0.9	0.1	-0.1	0.2
Systolic blood pressure, automated reading	2.1	6.0	13.7	1.9	-1.4	-2.2	-3.7
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.2	0.4	1.0	-0.6	-1.1
Angina	0.7	0.9	3.2	1.8	0.4	-0.1	-0.4
Medication for hormone replacement therapy	0.5	0.5	1.1	-0.6	-0.1	-0.8	-1.0
Vitamin and mineral supplements	0.8	1.1	3.8	-1.9	0.0	-0.7	-0.3
Supplements: Zinc	0.9	0.9	2.5	1.6	-0.9	-0.7	0.1
Medication: Co-codamol	2.7	3.2	5.1	1.0	-1.9	-2.3	-1.8
Medication: Metformin	0.4	0.6	1.1	1.0	0.9	0.6	0.1
Diabetes (father)	1.4	1.7	3.0	0.9	-1.3	-1.7	-1.2
Diabetes (mother)	0.1	0.1	0.2	0.4	0.3	-0.2	0.2
Severe depression (siblings)	0.3	0.3	0.5	0.7	-0.2	-0.6	-0.7
Pack years adult smoking proportion	3.6	5.5	7.3	2.6	-2.4	-2.7	-1.5
Impedance of leg (right)	3.4	16.4	22.8	2.3	-4.5	-4.8	-4.2
Leg fat-free mass (left)	0.8	4.4	7.0	-0.5	2.6	2.1	2.4
Trunk fat percentage	0.1	0.3	1.1	0.1	-0.3	-0.3	-1.1
Hand grip strength (right)	1.2	3.3	4.4	2.1	-1.0	-1.9	-2.0
Townsend deprivation index at recruitment	0.3	0.4	0.7	0.6	-0.0	-0.8	0.8
Current tobacco smoking	2.3	3.8	13.9	3.7	0.4	-0.5	1.0
Average weekly fortified wine intake	1.0	1.1	3.5	-1.9	-0.4	-0.0	0.9
Maternal smoking around birth	0.6	0.9	2.4	1.6	0.3	-0.5	-0.9
Fed-up feelings	0.2	0.4	1.1	0.1	-1.0	-0.7	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	0.8	0.9	-0.5	-0.5	0.2
Relative age voice broke	2.9	4.4	4.9	2.0	-2.1	-2.0	-2.2
Taking other prescription medications	0.7	1.0	1.6	0.0	1.3	1.2	1.0
Age when periods started (menarche)	0.2	0.5	1.3	0.6	-0.5	-0.4	-1.1
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	2.9	-0.3	1.7	1.5	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	1.5	-1.2	-1.1	-1.1	-0.9
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.7	0.4	1.2	1.3	0.7
Qualifications: CSEs or equivalent	3.9	5.1	8.6	-2.3	2.9	1.7	1.9
Serious illness, injury or assault to yourself	3.4	4.1	6.4	1.8	-1.8	-1.9	-2.5
High blood pressure	0.4	1.2	2.2	0.6	1.4	0.0	-1.5
Hayfever, allergic rhinitis or eczema	1.5	3.2	9.3	-3.0	-1.5	-1.1	-0.5
Multivitamins +/- minerals	0.1	0.2	0.5	0.7	-0.3	0.4	0.2
Stomach or abdominal pain in last month	0.5	0.7	1.9	-1.4	0.6	0.6	0.3
Supplements: Glucosamine	1.0	1.3	3.1	1.8	-0.5	-0.3	-1.3
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.3	-1.5	-0.2	-0.5	-1.4
Medication: Atenolol	1.6	2.0	3.2	1.8	-0.9	-1.3	-1.6
Medication: Levothyroxine sodium	0.1	0.1	0.2	0.3	0.4	-0.1	0.3
Sitting height	0.1	0.8	1.8	0.2	1.4	0.4	1.0
Chronic bronchitis/emphysema (father)	0.6	0.7	1.3	-0.9	1.1	0.6	0.5
High blood pressure (mother)	0.1	0.1	0.3	-0.4	0.5	0.1	-0.2
Body mass index (BMI)	0.2	0.7	1.2	-0.1	1.1	1.1	0.8
Impedance of leg (left)	2.3	11.3	14.0	2.5	-3.7	-3.7	-3.4
Leg predicted mass (left)	0.8	4.4	7.1	-0.4	2.7	2.2	2.4
Trunk fat mass	0.0	0.2	0.4	0.3	0.6	0.4	-0.2
Waist circumference	0.3	1.3	1.5	1.2	1.2	1.0	1.1
Number of incorrect matches in round	1.2	2.0	4.8	-2.2	-1.1	-1.2	-0.7
Past tobacco smoking	3.8	7.0	27.9	-5.3	0.1	-0.1	0.3
Alcohol usually taken with meals	2.3	3.7	7.8	-0.7	-2.8	-1.4	-2.1
Nervous feelings	3.6	6.7	11.8	-1.1	-3.1	-3.4	-2.1
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	5.2	0.7	-2.3	-1.7	-0.9
Hearing difficulty/problems with background noise	0.9	1.5	5.6	2.4	-0.2	-0.3	0.5
Hair/balding pattern: Pattern 2	0.4	0.5	1.2	-1.1	-0.6	-0.4	-0.6
Had menopause	0.4	0.5	1.5	1.2	0.4	0.5	-0.0
Had other major operations	1.5	1.8	2.6	-1.0	1.3	1.4	1.6
Forced vital capacity (FVC)	1.3	4.9	14.6	3.8	-0.8	-1.7	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	3.5	-1.9	-1.1	-1.5	-1.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.3	1.1	-0.2	-1.1	-0.6
Qualifications: None of the above	0.5	1.1	3.7	1.9	0.5	0.4	-0.7
Financial difficulties in last 2 years	3.4	4.5	6.9	1.4	-2.3	-2.6	-1.9
Mouth/teeth dental problems	2.6	4.0	7.1	0.6	-2.7	-1.9	-2.2
Heart attack	0.7	0.9	2.7	0.9	0.4	-0.3	-1.6
Allergy	0.9	2.2	7.4	2.7	0.8	0.7	0.2
Pain all over the body in last month	0.6	0.6	2.2	-1.5	-0.2	-0.5	-0.3
Diabetes (self-reported)	0.3	0.5	0.9	0.9	0.2	-0.4	-0.9
Hayfever/allergic rhinitis (self-reported)	2.3	3.0	9.7	-3.1	1.1	1.0	0.5
Medication: Ramipril	0.8	1.1	1.6	-1.0	1.3	1.2	0.5
Medication: Simvastatin	0.9	1.3	3.3	-0.7	1.8	1.1	0.5
Fluid intelligence score	0.6	1.3	1.9	0.1	-1.4	-1.4	-1.3
Illnesses of siblings	1.4	2.0	6.2	0.1	-2.5	-1.3	0.4
Neuroticism score	1.6	3.4	6.1	0.9	-2.5	-2.2	-1.4
Weight	0.2	1.1	1.9	0.8	1.4	1.0	0.9
Impedance of arm (right)	1.9	9.0	13.8	-0.3	-3.4	-3.3	-3.7
Arm fat percentage (right)	0.0	0.2	0.6	-0.3	0.2	0.0	-0.8
Trunk fat-free mass	0.8	4.4	7.5	0.9	2.7	2.0	2.3
Hip circumference	0.2	0.7	1.2	0.6	1.1	0.8	0.9
Time employed in main current job	2.8	3.3	5.9	-2.4	2.1	1.4	0.9
Alcohol intake versus 10 years previously	0.9	1.3	4.4	2.1	0.5	-0.3	-0.8
Father’s age at death	0.6	0.7	1.7	1.1	-1.3	-0.3	-0.1
Worrier / anxious feelings	2.5	4.8	5.9	-2.2	-2.4	-2.0	-2.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.5	0.2	0.7	0.3	0.7
Falls in the last year	0.1	0.2	0.4	0.2	0.7	0.1	-0.4
Hair/balding pattern: Pattern 3	0.8	1.2	2.7	1.6	0.6	0.9	1.0
Number of live births	0.1	0.1	0.4	0.2	-0.0	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1)	1.6	5.4	13.8	3.7	-1.1	-2.0	-1.7
Pulse rate	0.3	0.5	0.9	-0.2	-0.9	-0.4	-0.9
Happiness	0.6	0.7	1.4	1.2	-0.7	-0.7	-0.7
Noisy workplace	0.3	0.4	0.7	0.2	0.7	0.8	0.4
Qualifications: A levels/AS levels or equivalent	0.6	1.4	3.1	-0.7	-1.8	-1.2	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.9	1.4	0.1	0.1	0.6
Mouth/teeth dental problems: Dentures	1.1	1.9	3.7	0.8	1.9	1.3	1.2
Asthma	0.4	0.8	1.9	-1.4	0.6	0.5	0.9
Medication: Ibuprofen (e.g. Nurofen)	2.6	3.3	7.2	0.9	-2.0	-2.7	-1.1
Medication: Cholesterol lowering	0.7	1.2	2.6	-0.3	1.6	1.4	0.2
Depression (self-reported)	0.6	0.7	1.3	1.2	0.2	0.5	1.1
Medication: Lansoprazole	1.4	1.6	4.5	-2.1	0.3	-0.6	-1.1
Prospective memory result	2.4	3.0	4.0	-2.0	2.0	1.6	1.2
Lung cancer (father)	3.0	3.5	5.6	-0.4	2.0	2.4	2.1
Illnesses of mother	0.3	0.4	0.7	0.3	0.7	0.9	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.2	8.5	2.9	-1.3	-2.2	-1.4
Pulse wave Arterial Stiffness index	2.0	2.3	3.9	-1.8	2.0	1.4	0.5
Impedance of arm (left)	1.7	7.6	11.6	-0.8	-3.0	-3.1	-3.4
Arm fat mass (right)	0.1	0.3	0.7	-0.1	0.9	0.7	0.2
Trunk predicted mass	0.8	4.4	7.6	0.9	2.8	2.0	2.2
Standing height	0.1	1.0	3.1	1.8	0.9	0.1	0.4
Length of working week for main job	1.6	1.8	3.5	0.4	-1.1	-1.9	-1.5
Exposure to tobacco smoke at home	1.2	1.3	2.7	1.0	-1.6	-1.2	0.2
Breastfed as a baby	0.5	0.6	1.4	-0.2	0.4	1.2	0.8
Tense / ‘highly strung’	1.9	3.2	7.6	2.8	-1.6	-1.3	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.3	7.2	0.3	-1.5	-2.7	-1.9
Hair/balding pattern: Pattern 4	0.2	0.5	1.1	-0.4	0.7	1.0	0.6
Birth weight of first child	2.9	5.3	7.5	0.7	2.7	2.6	2.5
Peak expiratory flow (PEF)	1.3	2.9	10.1	3.2	-0.1	-1.0	-0.8
Pulse wave reflection index	3.0	3.7	8.4	-0.9	2.9	1.9	1.4
Ever highly irritable/argumentative for 2 days	1.7	2.0	3.7	0.2	-1.3	-1.9	-1.6
Loud music exposure frequency	1.4	1.5	3.0	1.1	-1.7	-1.2	-0.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.5	-1.2	-0.4	-0.3	0.5
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	3.0	-0.7	1.0	1.2	1.7
Blood clot in the leg (DVT)	0.6	0.8	1.7	-1.3	-0.8	-1.0	-0.1
Medication: Paracetamol	2.5	4.1	8.8	-1.3	-0.9	-3.0	-2.2
Headache pain in last month	1.1	1.9	3.3	-1.8	-0.2	-1.4	-1.5
Medication for cholesterol, blood pressure or diabetes	2.1	3.5	7.3	0.8	-2.7	-2.3	-1.0
Glaucoma (self-reported)	0.7	0.8	1.4	0.8	-1.2	-0.7	-0.9
Gout (self-reported)	0.3	0.5	1.2	-1.1	0.1	-0.1	-0.8
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.0	0.3	1.4	0.8	1.2
Medication: Amlodipine	0.5	0.7	1.0	-1.0	-0.4	-0.9	-1.0
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.5	-1.6	-0.5	-0.5	-0.5
Birth weight	8.2	17.9	23.5	-2.0	4.6	4.9	4.8
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	-0.7	-0.3	-0.5	-0.3
High blood pressure (siblings)	1.8	2.6	6.9	-1.2	2.6	1.4	0.2
Forced vital capacity (FVC), Best measure	1.0	3.6	7.7	2.8	-1.2	-2.0	-1.0
Body fat percentage	0.2	0.6	1.4	0.8	-0.5	-0.3	-1.2
Leg fat percentage (right)	0.4	1.5	3.4	1.9	-0.9	-0.7	-1.1
Arm fat-free mass (right)	1.2	6.0	9.1	1.3	3.0	2.5	2.7
Exposure to tobacco smoke outside home	2.1	2.8	10.3	3.2	-0.5	-0.7	-0.4
Comparative body size at age 10	0.5	1.3	4.0	2.0	-0.9	-0.5	-0.5
Number of full brothers	1.0	1.2	2.6	-0.5	1.6	0.4	1.4
Worry too long after embarrassment	3.5	5.8	8.4	1.6	-2.9	-2.9	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	0.5	0.1	-0.3	0.8
Wheeze or whistling in the chest in last year	4.6	8.2	10.9	-2.3	3.3	2.8	3.0
Number of children fathered	1.7	1.9	2.9	1.6	-1.7	-1.2	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	2.2	-0.4	0.9	0.4	1.5
Age at first live birth	4.0	7.1	12.8	-1.4	2.3	3.6	2.9
Pulse wave peak to peak time	1.8	2.1	3.4	1.8	-1.8	-1.3	-0.4
Health satisfaction	0.3	0.4	0.8	-0.3	-0.3	-0.9	-0.7
Shortness of breath walking on level ground	1.3	1.5	3.0	-0.7	1.7	1.4	0.7
Qualifications: College or University degree	2.1	6.7	10.3	0.3	-3.2	-2.6	-3.2
Eye problems/disorders: None of the above	0.8	0.9	3.3	1.8	0.2	0.6	-0.2
Mouth/teeth dental problems: Loose teeth	2.3	2.7	4.3	-0.2	1.9	1.7	2.1
Emphysema/chronic bronchitis	0.5	0.5	0.9	0.9	-0.5	-0.6	-0.8
Medication for pain relief, constipation, heartburn	1.0	1.7	3.9	1.1	0.5	2.0	1.2
Neck or shoulder pain in last month	2.0	2.8	4.4	1.3	-1.0	-2.1	-2.0
Medication: Blood pressure	1.8	3.1	5.9	-0.8	2.4	1.9	1.5
Angina (self-reported)	0.9	1.2	4.3	2.1	0.2	-0.3	-0.7
Migraine (self-reported)	0.5	0.6	1.1	-0.5	1.0	0.8	0.8
Medication: Ibuprofen	2.3	2.8	6.3	0.8	-1.8	-2.5	-0.9
Medication: Allopurinol	1.6	2.2	5.8	0.4	-0.9	-1.4	-2.4
Medication: Omeprazole	0.0	0.1	0.1	-0.3	0.1	-0.3	-0.1
Medication: Seretide 50 evohaler	2.8	3.2	6.8	0.4	1.7	1.7	2.6
Mean time to correctly identify matches	0.5	1.0	1.8	0.2	0.8	1.4	1.2
Heart disease (mother)	0.9	1.1	1.6	-0.2	-1.1	-1.2	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.0	-1.0	0.3	-0.4	0.2
Whole body fat mass	0.1	0.4	0.7	0.8	0.6	0.7	-0.0
Leg fat mass (right)	0.1	0.4	1.4	1.2	0.4	0.1	-0.0
Arm predicted mass (right)	1.1	5.6	8.1	1.3	2.8	2.3	2.7
Pulse rate, automated reading	0.8	2.5	4.3	-1.0	-1.4	-1.6	-2.1
Alcohol intake frequency.	0.3	0.6	1.4	1.2	-0.1	-0.9	-0.5
Comparative height size at age 10	0.5	2.6	4.6	0.9	1.8	1.3	2.1
Number of full sisters	0.2	0.3	0.5	0.2	-0.4	-0.7	-0.5
Suffer from ‘nerves’	0.7	1.2	2.8	-0.4	-1.7	-1.3	0.1
Overall health rating	0.3	0.6	1.7	1.3	0.8	0.2	0.2
Chest pain or discomfort	0.1	0.1	0.5	0.3	0.7	-0.0	0.1
Had major operations	2.6	3.1	6.7	2.6	-1.4	-1.5	-1.2
Age at last live birth	4.0	5.8	11.0	-0.6	2.0	3.3	2.8
Family relationship satisfaction	3.0	3.7	9.3	3.0	-1.7	-1.4	-0.9
Leg pain on walking	0.2	0.2	0.6	0.8	0.0	0.3	0.6
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	3.4	0.2	1.2	1.0	1.8
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.5	-0.5	0.7	0.4	0.7
Illness, injury, bereavement, stress in last 2 years	3.8	4.6	7.0	-1.7	2.2	2.6	1.9
Medication: Aspirin	1.8	2.4	5.3	-0.9	2.3	1.7	0.8
Supplements: Vitamin C	1.7	2.0	3.0	0.4	1.4	1.7	1.7
Knee pain experienced in last month	0.6	1.0	1.5	1.1	0.7	0.8	1.2
Hypertension (Self-reported)	0.4	1.1	3.0	0.9	0.8	-0.3	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.7	0.7	0.1	-0.6	-0.8
Illnesses of father: Heart disease	0.3	0.4	0.9	0.7	0.2	-0.5	-0.9
Illnesses of siblings: Diabetes	0.7	0.9	2.2	-1.5	0.9	0.2	0.6
Smoking status: Previous	2.8	4.1	15.7	4.0	-0.4	0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.0	-0.5	-0.2	-1.0	-0.9
Whole body fat-free mass	0.9	5.1	8.4	0.5	2.9	2.3	2.5
Leg fat-free mass (right)	1.2	6.4	9.7	-0.5	3.1	2.8	2.9
Arm fat percentage (left)	0.0	0.2	0.5	-0.4	0.3	0.1	-0.7
Average weekly red wine intake	0.1	0.2	0.3	-0.6	-0.5	-0.1	-0.4
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.0	0.0	0.4	0.3	1.0
Mood swings	0.7	1.2	4.1	0.4	-0.5	0.5	2.0
Loneliness, isolation	0.3	0.4	1.0	0.3	-1.0	-0.5	0.4
Long-standing illness, disability or infirmity	0.4	0.5	1.6	1.3	-0.2	-0.7	-0.3
Ever had bowel cancer screening	0.7	0.8	1.8	-1.0	1.3	0.6	-0.1
Diabetes diagnosed by doctor	0.2	0.3	0.7	0.8	0.8	0.2	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	2.3	0.9	1.0	1.2	1.5
Friendships satisfaction	0.3	0.4	1.0	0.3	-1.0	-0.5	0.3
Qualifications: nursing, teaching	0.0	0.1	0.1	0.0	-0.3	-0.1	-0.4
Commuting to job workplace: Walk	0.2	0.3	0.7	-0.2	0.3	0.8	0.4
Eye problems/disorders: Cataract	0.9	1.1	1.6	-1.1	-1.3	-1.1	-0.3
Mouth/teeth dental problems: Mouth ulcers	2.9	4.6	5.7	-2.4	2.4	1.7	2.0
Medication for cholesterol	0.5	0.7	1.2	1.0	-0.8	0.0	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.7	0.7	1.3	0.1	0.5
Back pain experienced in last month	0.8	1.1	4.4	2.1	0.0	-0.4	-0.0
Mineral and other dietary supplements	1.4	1.8	6.5	-2.5	-0.3	-0.5	0.7
Breast cancer (self-reported)	2.7	3.2	5.1	0.2	2.3	1.7	2.2
Asthma (self-reported)	0.4	0.8	2.5	-1.6	0.3	0.2	0.7
Osteoporosis (self-reported)	2.1	2.6	7.8	2.8	0.1	1.1	1.2
Osteoarthritis (self-reported)	0.3	0.4	0.8	0.9	0.2	-0.5	-0.8
Medication: Aspirin	1.3	1.7	4.5	-0.7	2.1	1.3	0.2
Medication: Gliclazide	1.0	1.1	3.7	1.9	0.4	0.8	0.1
Illnesses of father: None of the above (group 1)	0.4	0.5	0.9	-0.5	-0.3	0.8	1.0
Smoking status: Current	2.1	3.4	11.2	3.3	0.9	-0.0	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.0	8.4	14.1	3.8	-2.6	-2.8	-2.2
Whole body water mass	0.9	4.9	8.1	0.5	2.9	2.3	2.4
Leg predicted mass (right)	1.2	6.5	9.7	-0.5	3.1	2.8	2.9
Arm fat mass (left)	0.1	0.4	1.0	0.1	1.0	0.8	0.4
Number of self-reported non-cancer illnesses	0.6	1.1	1.9	-0.8	1.4	1.2	0.4
Average weekly champagne plus white wine intake	0.4	0.6	1.1	0.9	-0.7	1.0	-0.4
Miserableness	0.5	0.8	1.0	1.0	-0.9	-1.0	-0.6
Guilty feelings	0.3	0.4	0.6	0.7	-0.7	-0.3	0.7
Wears glasses or contact lenses	0.5	0.6	1.4	-0.0	0.9	1.2	0.3
Ever taken oral contraceptive pill	0.5	0.6	1.3	1.1	-0.8	-0.6	0.0
Hearing aid user	0.8	0.8	1.1	1.1	-1.1	-1.1	0.1
Mother’s age at death	0.5	0.7	1.7	0.8	-1.3	-0.1	-0.5
Financial situation satisfaction	0.8	1.0	2.5	0.2	1.1	0.6	1.6
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.1	0.5	0.3	0.4	1.0
Commuting to job workplace: Public transport	2.9	3.5	6.1	0.8	-2.5	-2.1	-1.6
Eye problems/disorders: Glaucoma	1.4	1.6	3.0	0.1	-1.7	-1.2	-1.4
Medication: Blood pressure	0.7	1.3	4.0	0.3	0.0	-1.1	-2.0
Pain type(s) experienced in last month: Hip pain	1.2	1.6	5.0	2.2	-0.8	-0.8	0.3
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.2	1.5	0.8	0.8	-0.5
High cholesterol (Self-reported)	0.4	0.6	1.2	-0.9	1.1	0.7	0.2
Medication: Bendroflumethiazide	0.8	1.2	3.2	-0.9	1.8	0.8	-0.1
Medication: Paracetamol	1.9	2.9	5.5	-1.3	-0.6	-2.4	-2.0
Medication: Lisinopril	0.8	1.1	2.3	-1.5	0.3	-0.5	-1.3
Medication: Atorvastatin	0.9	1.1	2.8	1.7	-0.2	-0.6	-1.2
Illnesses of father: High blood pressure	3.1	3.9	5.4	1.1	-2.2	-2.3	-2.0
Alcohol drinker status: Never	0.3	0.4	0.8	-0.3	0.7	0.5	0.9
Ever smoked	4.3	7.5	27.8	5.3	-1.0	-0.9	-0.7
Basal metabolic rate	0.7	3.9	6.6	0.4	2.6	2.0	2.2
Leg fat percentage (left)	0.2	0.7	2.8	1.7	0.0	0.3	-0.3
Arm fat-free mass (left)	0.9	4.8	6.9	1.3	2.6	2.2	2.4
Number of operations (self-reported)	0.1	0.1	0.2	-0.2	-0.3	-0.2	-0.4
Average weekly beer plus cider intake	2.6	3.7	5.4	-1.6	2.3	1.5	2.2
Irritability	0.8	1.3	3.2	1.8	0.2	-0.4	-1.4
Risk taking	1.1	1.7	2.7	1.0	-0.9	-1.4	-1.6
Ever had prostate specific antigen (PSA) test	2.7	3.2	4.5	-2.0	2.0	2.1	0.2
Fractured/broken bones in last 5 years	2.5	3.2	4.4	2.0	-2.1	-1.6	-1.5
Age started oral contraceptive pill	0.6	0.8	1.7	0.2	1.1	1.3	0.5
Diastolic blood pressure, automated reading	0.8	2.5	8.6	0.0	2.9	1.1	-0.4
Ever depressed for a whole week	0.9	1.1	2.0	-0.7	-0.1	-1.4	-1.4
Unable to work because of sickness or disability	0.1	0.1	0.2	0.3	0.5	-0.4	0.3
Commuting to job workplace: Cycle	0.3	0.4	1.0	1.0	-0.5	-0.3	0.5
Myopia	0.7	1.0	2.3	-1.5	0.5	0.9	0.9
Vascular/heart problems diagnosed by doctor	0.5	1.4	3.1	-1.0	-1.8	-0.4	1.2
Cholesterol lowering medication	0.1	0.2	0.3	0.4	0.5	-0.1	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.1	-0.4	-0.4	-0.4
Pain experienced in last month	0.2	0.4	0.8	0.9	-0.2	0.7	0.5
Supplements: Calcium	3.9	4.3	13.4	3.7	-1.7	-0.2	-0.7
Basal cell carcinoma (self-reported)	0.3	0.4	0.7	-0.8	0.4	0.5	0.6
Heart attack/myocardial infarction (self-reported)	0.6	0.7	2.2	0.7	0.5	-0.3	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.9	-1.7	-0.8	-0.8	-0.1
Heart disease (siblings)	1.0	1.2	2.6	0.9	1.6	1.0	0.4
Alcohol drinker status: Previous	0.8	0.9	1.8	-0.8	1.3	0.9	0.5
Pack years of smoking	3.1	4.6	6.9	2.6	-2.0	-2.3	-1.4
Impedance of whole body	2.2	11.3	15.1	0.5	-3.9	-3.8	-3.9
Leg fat mass (left)	0.2	0.7	1.3	1.1	0.8	0.7	0.4
Arm predicted mass (left)	0.8	4.1	6.1	1.1	2.5	2.0	2.2