Hub : Genes

GFOD2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0230 0.0130 1.7e-03 0.010 0.006 0.008 0.003 0.010 0.01800 0.0610 3.4e-02 0.12 0.01900
2 GTEx Cells EBV-transformed lymphocytes 0.1070 0.0710 8.1e-03 0.072 NA 0.019 NA 0.048 0.00230 NA 7.5e-02 NA 0.01100
3 GTEx Esophagus Mucosa 0.0680 0.0280 2.2e-05 0.045 NA 0.064 NA 0.057 0.00055 NA 4.5e-05 NA 0.00011
4 GTEx Skin Sun Exposed Lower leg 0.0480 0.0340 5.7e-03 0.004 NA 0.057 NA 0.027 0.14000 NA 1.6e-05 NA 0.00260
5 GTEx Thyroid 0.1840 0.0810 1.6e-03 0.006 NA 0.020 NA 0.015 0.11000 NA 1.1e-02 NA 0.02300
6 TCGA Breast Invasive Carcinoma 0.0196 0.0118 2.1e-03 0.000 0.009 0.006 NA 0.002 0.31000 0.0050 1.7e-02 NA 0.10000
7 TCGA Head and Neck Squamous Cell Carcinoma 0.0267 0.0152 3.9e-04 0.031 0.021 0.024 NA 0.028 0.00016 0.0016 9.4e-04 NA 0.00036
8 TCGA Prostate Adenocarcinoma 0.0389 0.0222 1.9e-03 0.027 0.028 0.009 NA 0.017 0.00069 0.0006 3.4e-02 NA 0.00550
9 TCGA Testicular Germ Cell Tumors 0.3700 0.1350 2.4e-03 0.007 0.003 0.004 NA 0.026 0.17000 0.2400 2.2e-01 NA 0.04200

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 1.6 2.6 8.7 -1.6 -1.5 -1.1 -2.0 0.8 -0.9 -2.9 -1.8 0.0
Bipolar Disorder or Schizophrenia 3.6 8.9 17.6 -3.3 -3.5 -2.9 -3.4 -0.0 -2.9 -4.2 -3.3 0.0
Depressed Affect (Nagel 2018) 0.8 1.7 5.3 -1.4 -1.7 -1.6 -1.1 0.5 -2.3 -0.2 -0.9 0.5
Depression (Nagel 2018) 2.1 3.2 5.6 -2.3 -2.3 -2.4 -1.2 -0.3 -2.3 0.4 -1.2 2.1
Intelligence (Savage-Jansen 2018) 2.6 8.1 15.0 3.3 3.9 3.5 2.6 -0.7 3.8 0.3 2.4 -2.7
Neuroticism (Nagel 2018) 1.8 4.2 10.4 -2.5 -2.7 -2.5 -1.7 0.1 -3.2 -0.5 -1.9 0.9
Schizophrenia (2018) 3.3 6.8 11.0 -2.9 -3.3 -2.8 -2.9 -0.5 -3.0 -3.0 -2.7 0.0
Schizophrenia vs Biploar Disorder 1.7 2.3 6.1 -1.1 -1.7 -2.2 -2.5 1.0 -1.8 0.1 -1.1 0.0
Worry (Nagel 2018) 2.0 4.2 9.0 -2.7 -2.8 -2.3 -1.6 -0.5 -3.0 -0.9 -2.0 0.9
Alzheimer’s Disease (in mother) 0.3 0.4 1.5 0.1 -0.3 -1.2 -0.3 0.5 -0.0 1.2 0.4 0.1
Alzheimer’s Disease (in father) 1.6 1.8 4.3 -1.7 -1.2 -0.9 -1.4 -0.3 -2.1 -1.4 -1.6 0.1
Alzheimer’s Disease (including proxy) 0.4 0.6 1.7 -0.8 -0.8 -1.3 -0.7 0.4 -1.3 0.2 -0.4 -0.1
Crohns Disease (2017) 1.9 4.2 9.6 2.3 2.1 2.2 0.2 -3.1 2.7 0.6 0.8 -2.4
Irritable Bowel Disease (IBD) 0.5 1.2 7.3 0.6 0.6 0.4 -0.7 -2.7 1.2 0.6 0.3 0.1
Ulcerative Colitis (UC) 0.9 1.8 5.4 -1.3 -1.3 -1.6 -1.7 -0.9 -0.8 0.0 -0.6 2.3
Major Depression (MDD) 0.4 0.5 1.8 -0.2 -0.4 -0.8 -0.8 1.1 -0.1 -1.3 -0.3 0.2
Reaction Time 0.4 0.8 3.6 -0.8 -0.4 -0.9 0.5 0.7 0.1 0.9 -0.2 1.9
Verbal and Numeric Reasoning (VNR) 2.4 5.9 10.5 2.9 3.2 2.8 2.6 -0.4 2.8 0.1 2.0 -2.7
Breast Cancer 0.8 2.0 3.6 1.6 1.7 1.8 1.5 -1.0 0.8 1.2 1.9 -0.1
Ovarian Cancer 7.8 10.4 17.7 3.5 3.7 3.5 3.7 -2.3 2.3 2.2 4.2 -2.9
Prostate Cancer 2.3 3.2 5.7 2.4 1.8 1.6 2.3 -0.9 1.4 1.1 2.4 -1.6
Age at First Birth 1.2 1.8 3.3 1.2 1.8 1.7 0.9 -1.0 1.8 -1.1 0.4 -1.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 1.3 0.2 0.2 0.0 -0.2 0.7 0.7 -1.2 -0.4 -0.8
Coronary Artery Disease (CAD) 2.1 2.5 5.2 1.8 1.7 1.6 2.3 -0.0 1.6 0.8 1.5 -1.7
Crohns Disease (2012) 1.2 1.9 3.2 1.7 1.4 1.2 -0.2 -1.3 1.8 0.9 1.6 -1.4
Mean Putamen Volume 0.7 0.8 2.1 0.6 0.3 1.0 1.3 -0.2 0.1 -1.4 0.2 -1.3
Fasting Glucose 5.1 6.1 8.9 2.5 3.0 2.7 2.6 -1.0 3.0 2.0 2.5 -2.2
HbA1C 0.3 0.3 1.0 0.5 0.7 0.4 0.2 0.4 1.0 -0.1 0.0 -0.6
HDL Cholesterol 51.7 86.2 151.3 -10.0 -11.2 -11.7 -10.2 3.5 -9.4 -0.3 -7.5 12.3
LDL Cholesterol 0.1 0.2 0.8 -0.3 -0.4 -0.5 -0.2 -0.2 -0.5 -0.4 -0.1 0.9
Lupus 2.6 3.9 10.6 -2.3 -2.5 -2.5 -1.6 -0.1 -1.5 -0.8 -1.4 3.2
Neuroticism (2016) 1.9 2.8 5.3 -1.9 -2.3 -2.2 -1.1 0.2 -2.3 -0.3 -1.4 1.6
Primary Biliary Cirrhosis 3.5 5.0 12.1 -2.3 -3.0 -3.5 -2.5 0.8 -1.8 0.6 -1.4 2.5
Rheumatoid Arthritis 0.2 0.2 0.9 0.2 0.8 1.0 0.4 -0.6 -0.3 -0.2 0.2 0.0
Schizophrenia (2014) 3.1 6.9 12.0 -2.9 -3.5 -3.3 -3.2 -0.3 -3.0 -2.2 -2.7 0.0
Triglycerides 1.3 2.1 4.6 1.3 1.7 1.5 1.6 -1.5 1.4 0.1 0.7 -2.2
Type 2 Diabetes (T2D) (2012) 1.0 1.1 2.1 1.1 1.0 1.1 0.8 0.0 1.3 -1.3 0.5 -1.5
Ulcerative Colitis 0.4 0.6 1.4 -0.6 -0.5 -0.8 -0.9 -1.2 -0.3 0.3 -0.2 1.1
Blood Eosinophil Count 1.1 8.4 16.6 -1.8 -3.0 -3.7 -1.4 3.9 -4.1 3.1 0.7 2.3
Blood Platelet Count 0.2 2.2 10.4 0.8 0.3 -0.9 -1.5 1.0 1.1 3.2 1.5 0.9
Blood Red Count 8.7 84.0 141.6 -11.2 -11.1 -10.4 -8.5 3.4 -9.0 -6.5 -11.9 7.1
Blood White Count 0.5 3.7 13.0 1.5 0.7 -0.8 0.4 1.4 1.8 3.6 3.4 0.4
Heel T-Score 1.1 8.7 31.2 -1.9 -1.2 0.9 -1.2 -5.4 -0.8 -5.6 -2.8 1.5
BMI 0.3 2.0 9.1 -0.7 -0.5 -0.7 -1.2 3.0 0.4 -1.4 -2.0 0.5
Height 0.7 13.9 69.9 2.5 1.5 0.3 -1.4 -5.0 3.0 8.4 1.9 -2.8
Waist Hip Ratio (WHR) 1.8 8.3 33.4 2.7 2.0 0.8 0.9 -1.1 2.4 5.8 4.7 0.4
Systolic Blood Pressure 0.1 0.4 1.2 -0.1 0.8 0.1 0.3 1.1 0.9 -0.6 -0.7 -0.5
Smoking Status 0.4 1.0 2.2 -1.0 -1.2 -1.4 -1.1 -0.2 -1.5 -0.1 -1.0 0.3
Allergy or Eczema 1.6 4.2 9.1 2.1 2.5 3.0 2.2 -0.3 1.6 -0.3 2.2 -2.3
Cardiovascular Disease 0.3 1.1 2.9 -0.6 -0.5 -1.6 -0.5 1.7 0.3 1.1 -0.1 1.5
Hypothyroidism (self reported) 5.1 11.6 28.0 -3.3 -3.9 -2.5 -3.0 1.5 -3.7 -5.3 -4.4 -0.3
Respiratory disease 1.3 2.9 7.2 1.9 2.2 2.7 2.1 -0.7 1.3 -0.3 1.8 -0.9
Type 2 Diabetes (T2D) (2018) 0.2 0.3 1.3 0.0 -0.1 -0.3 0.3 0.4 -0.1 1.1 1.1 0.2
Lung FEV1/FVC ratio 11.8 59.6 102.5 -8.9 -8.6 -7.4 -5.5 5.6 -8.6 -7.8 -10.1 5.5
Lung FVC 2.3 11.6 21.8 4.1 4.5 3.6 3.5 -1.3 4.7 0.7 3.0 -3.2
Neuroticism 2.0 4.9 13.9 -2.7 -2.6 -2.4 -1.6 0.1 -3.7 -0.7 -2.3 1.2
Chronotype (morning person) 2.0 4.7 6.9 2.6 2.6 2.0 0.7 -1.1 2.6 2.6 2.0 -2.3
Hair Pigment 0.5 14.8 22.4 -4.7 -4.2 -3.6 -3.6 2.1 -3.8 -3.3 -4.7 3.8
Tanning 0.1 0.8 2.9 -0.1 -1.0 -0.9 -1.7 0.9 -0.6 0.7 -0.1 0.9
Hand grip strength (left) 0.1 0.3 1.5 0.4 0.3 0.3 -0.6 0.0 0.1 0.4 -0.4 -1.2
Number of treatments/medications taken 1.5 2.6 11.0 -1.3 -1.6 -1.9 -0.6 1.8 -0.8 0.7 0.1 3.3
Average weekly spirits intake 2.7 3.3 5.3 2.1 2.1 2.0 1.9 -0.9 1.9 1.7 2.3 -1.0
Sensitivity / hurt feelings 0.4 0.7 2.1 -0.8 -0.9 -1.3 -0.4 -0.6 -0.6 1.4 -0.2 0.5
Frequency of depressed mood in last 2 weeks 1.9 2.6 4.5 -2.1 -2.1 -1.9 -0.9 -0.2 -2.1 -0.3 -1.4 1.9
Hearing difficulty/problems: Yes 0.8 1.2 2.6 0.9 1.0 1.5 1.6 -1.0 0.7 -0.8 1.3 -0.4
Relative age of first facial hair 0.2 0.3 2.2 -0.0 0.6 0.1 0.5 1.5 0.1 0.3 0.3 0.4
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.8 0.1 0.0 -0.3 -0.1 -0.9 0.8 0.3 0.2 -0.1
Ever used hormone-replacement therapy (HRT) 0.5 0.6 2.1 0.8 0.4 0.3 0.2 -0.7 1.5 0.7 1.2 -0.3
Ever had hysterectomy (womb removed) 0.3 0.4 1.8 -0.1 -0.3 -0.5 -1.3 0.9 0.2 0.2 0.0 -0.6
Systolic blood pressure, automated reading 0.3 0.8 2.3 0.5 1.0 0.6 0.6 0.7 1.5 -0.9 -0.2 -1.3
Eye problems/disorders: Diabetes related eye disease 0.1 0.2 0.7 0.2 0.1 0.0 0.3 -0.4 0.4 0.3 0.4 0.8
Angina 0.2 0.3 1.4 0.3 0.3 0.2 -0.3 -1.2 -0.0 0.3 0.1 -0.9
Medication for hormone replacement therapy 0.4 0.5 1.3 -0.3 -0.2 -0.7 -0.8 1.1 0.6 0.5 0.2 1.1
Vitamin and mineral supplements 1.1 1.4 3.6 1.4 1.5 0.8 1.4 0.2 1.9 1.2 0.8 -0.8
Supplements: Zinc 2.8 3.0 5.8 -2.2 -1.9 -1.7 -2.1 0.8 -2.4 -1.1 -1.7 1.1
Medication: Co-codamol 1.2 1.4 2.3 -1.0 -1.5 -0.9 -1.1 1.4 -1.2 -1.1 -1.3 0.8
Medication: Metformin 0.1 0.1 0.4 0.1 -0.0 0.1 0.1 0.4 -0.1 -0.6 0.1 0.3
Diabetes (father) 1.0 1.2 3.0 -1.1 -1.5 -1.5 -1.7 0.7 -0.9 -0.1 -1.0 0.2
Diabetes (mother) 1.6 2.0 8.1 -1.1 -1.9 -1.5 -0.4 -0.9 -2.8 0.4 -0.3 1.4
Severe depression (siblings) 0.4 0.4 1.3 -0.2 -0.5 -0.3 -0.4 1.1 -1.2 -0.1 -0.6 -0.4
Pack years adult smoking proportion 1.1 1.7 3.9 1.6 1.1 0.7 1.6 -0.6 1.0 1.9 2.0 0.1
Impedance of leg (right) 0.7 3.6 17.9 0.1 -1.1 -1.9 -0.6 -1.9 -0.4 4.2 2.2 0.8
Leg fat-free mass (left) 0.3 1.5 3.1 1.0 1.2 1.1 -0.6 -0.8 1.8 1.2 -0.9 -1.7
Trunk fat percentage 0.9 3.8 7.5 -1.1 -2.1 -2.7 -2.4 2.6 -0.3 2.2 -0.0 1.9
Hand grip strength (right) 0.2 0.5 2.2 -0.2 -0.3 -0.1 -1.5 0.4 -0.3 0.0 -1.1 -1.1
Townsend deprivation index at recruitment 0.7 1.0 2.7 1.2 0.7 1.5 1.2 0.6 0.2 -0.3 1.6 -0.4
Current tobacco smoking 0.7 1.2 7.0 0.9 0.4 -0.5 -0.2 0.8 0.3 2.6 1.2 0.1
Average weekly fortified wine intake 0.2 0.2 0.5 -0.0 0.3 0.7 0.5 0.3 -0.2 -0.6 -0.6 -0.4
Maternal smoking around birth 0.4 0.5 2.7 -0.1 0.0 -0.1 -0.5 -1.6 0.0 1.3 0.1 0.3
Fed-up feelings 0.5 1.0 4.4 -1.0 -1.1 -0.9 0.7 0.4 -2.1 -0.3 -0.7 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.8 2.3 6.8 -1.8 -2.1 -1.9 -1.0 -0.1 -2.6 -0.1 -1.0 1.1
Relative age voice broke 0.4 0.6 2.0 0.5 0.6 0.6 -0.8 1.4 0.6 -1.0 0.1 0.6
Taking other prescription medications 0.4 0.7 2.7 -0.7 -1.1 -0.5 0.1 -0.6 -0.8 -0.5 -0.2 1.6
Age when periods started (menarche) 0.2 0.5 1.7 -0.4 -0.5 -0.6 -1.3 -0.1 0.3 -0.6 -0.7 0.9
Bilateral oophorectomy (both ovaries removed) 1.7 2.0 5.0 -1.6 -1.5 -2.2 -1.2 1.7 -0.5 -0.7 -1.4 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.9 11.9 0.2 0.4 1.4 -0.2 -3.5 0.5 -1.5 -0.3 -0.1
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.1 -1.1 -0.7 -0.6 -0.1 0.4 -0.4 -0.5 -0.2 0.2
Qualifications: CSEs or equivalent 2.4 3.1 7.8 -1.8 -1.4 -1.0 -1.4 1.0 -2.0 -2.7 -2.8 0.0
Serious illness, injury or assault to yourself 2.0 2.4 6.9 1.3 1.1 0.8 0.1 -1.7 1.8 2.6 1.9 -1.1
High blood pressure 0.4 1.0 2.2 0.1 0.3 -0.7 1.3 1.2 1.4 0.8 0.9 1.5
Hayfever, allergic rhinitis or eczema 0.5 1.1 3.1 0.6 1.0 1.8 1.4 0.4 0.0 -1.2 0.6 -1.2
Multivitamins +/- minerals 1.3 1.7 3.7 -1.4 -1.6 -1.2 -1.9 0.1 -1.7 -1.1 -1.2 -0.0
Stomach or abdominal pain in last month 2.8 3.5 6.7 -2.6 -2.5 -2.4 -1.4 1.4 -2.0 -0.7 -1.4 1.6
Supplements: Glucosamine 1.6 2.1 3.7 1.8 1.5 1.4 -0.6 -0.4 1.9 1.6 1.7 -1.5
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 2.7 -0.4 -0.2 0.3 1.5 0.0 -0.6 -0.0 0.6 1.6
Medication: Atenolol 1.5 1.9 3.9 -1.2 -1.1 -2.0 -1.7 0.7 1.1 1.0 -0.9 2.0
Medication: Levothyroxine sodium 2.2 3.7 16.4 -1.3 -1.4 -0.5 -1.0 1.2 -2.0 -4.0 -2.3 -1.3
Sitting height 0.7 5.1 27.6 0.7 0.4 0.5 -0.7 -5.2 1.9 1.6 -1.8 -2.8
Chronic bronchitis/emphysema (father) 0.7 0.8 4.4 0.7 0.5 0.4 0.3 -2.1 0.2 1.0 1.0 -0.1
High blood pressure (mother) 1.0 1.4 3.9 -1.5 -1.4 -1.6 -0.2 0.7 -0.5 -0.6 -0.6 2.0
Body mass index (BMI) 0.2 1.0 6.7 -0.2 -0.2 -0.3 -0.4 2.6 0.3 -0.5 -0.9 0.8
Impedance of leg (left) 0.9 4.5 16.6 -0.7 -2.0 -2.8 -1.4 -1.0 -0.8 4.1 1.8 2.2
Leg predicted mass (left) 0.3 1.4 2.9 0.9 1.1 1.0 -0.6 -0.8 1.7 1.3 -0.9 -1.6
Trunk fat mass 0.6 2.4 8.4 -0.3 -1.1 -1.9 -2.0 1.8 0.6 2.9 0.0 1.0
Waist circumference 0.7 2.7 11.8 1.6 1.1 0.3 0.4 0.6 2.2 3.4 1.7 0.7
Number of incorrect matches in round 1.0 1.6 6.2 -1.3 -1.4 -1.5 0.2 0.3 -0.9 1.2 0.2 2.5
Past tobacco smoking 0.4 0.8 2.0 0.9 0.9 0.5 0.8 1.2 0.6 1.4 0.5 -0.7
Alcohol usually taken with meals 1.9 3.1 8.4 -1.9 -1.7 -1.2 -1.2 0.8 -1.8 -2.9 -2.2 1.0
Nervous feelings 1.6 3.1 6.9 -2.2 -2.1 -1.2 -0.9 -0.9 -2.6 -1.9 -2.1 -0.0
Frequency of tenseness / restlessness in last 2 weeks 4.6 7.2 16.6 -3.4 -3.5 -3.1 -2.3 0.3 -4.1 0.1 -2.7 1.5
Hearing difficulty/problems with background noise 0.2 0.3 0.9 0.0 -0.2 0.2 1.0 -0.7 0.3 -0.5 0.6 0.7
Hair/balding pattern: Pattern 2 0.9 1.2 4.9 -1.2 -1.1 -1.1 -2.2 -0.1 -0.1 -0.1 -1.3 0.5
Had menopause 0.1 0.1 0.3 -0.2 -0.3 -0.5 0.4 0.1 -0.3 0.5 0.2 0.4
Had other major operations 1.9 2.4 3.7 -1.9 -1.8 -1.4 -1.4 1.3 -1.9 -0.5 -1.8 1.4
Forced vital capacity (FVC) 2.6 10.0 16.5 3.6 3.6 2.7 2.1 -2.6 4.1 3.3 2.4 -3.6
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.4 14.4 0.4 0.7 1.8 0.1 -3.8 0.6 -1.5 -0.1 -0.9
Ever unenthusiastic/disinterested for a whole week 2.2 2.6 6.3 -2.1 -2.5 -2.0 -0.8 0.1 -1.6 -0.4 -1.6 1.8
Qualifications: None of the above 0.5 1.0 4.7 0.4 -0.0 -0.3 0.8 0.5 0.1 1.5 2.2 0.7
Financial difficulties in last 2 years 1.4 1.8 5.9 -0.8 -0.6 -1.6 -0.5 1.1 -0.9 2.4 -0.5 2.2
Mouth/teeth dental problems 0.6 0.9 2.9 0.5 0.5 -0.8 -0.2 1.7 1.4 1.2 0.4 0.3
Heart attack 2.0 2.6 5.3 -1.9 -1.8 -1.7 -1.5 -0.9 -2.3 -0.3 -1.4 1.9
Allergy 0.3 0.7 1.9 -0.2 -0.5 -1.4 -1.2 -0.4 0.4 1.3 -0.3 0.6
Pain all over the body in last month 0.5 0.5 1.5 -0.4 -0.3 -0.5 1.0 1.2 -1.0 0.4 -0.4 0.3
Diabetes (self-reported) 0.1 0.2 0.7 -0.3 -0.4 -0.4 0.7 -0.3 -0.4 0.8 0.0 -0.4
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 2.0 1.0 0.7 1.0 1.2 -1.0 0.1 1.4 1.4 -1.0
Medication: Ramipril 0.1 0.2 0.7 0.4 -0.0 0.0 -0.2 -0.9 0.2 0.3 0.7 0.1
Medication: Simvastatin 0.7 1.1 2.9 -1.0 -1.4 -1.7 -1.5 -0.2 -0.0 0.6 0.3 1.0
Fluid intelligence score 3.8 7.8 12.8 3.4 3.6 3.0 2.9 -1.1 3.2 1.2 2.9 -2.8
Illnesses of siblings 0.7 1.0 4.0 -0.9 -1.0 -0.3 -2.0 -0.4 -1.0 -0.6 -1.3 -0.1
Neuroticism score 1.7 3.6 12.9 -2.4 -2.4 -1.7 -1.2 -0.0 -3.6 -0.6 -1.7 0.6
Weight 0.3 1.4 6.9 1.1 0.7 0.2 -0.6 0.1 1.9 2.6 -0.0 -0.4
Impedance of arm (right) 0.7 3.4 8.1 -1.2 -2.3 -2.9 -1.9 0.5 -1.4 2.5 1.1 1.6
Arm fat percentage (right) 0.6 2.3 10.9 -0.8 -1.2 -1.6 -1.1 3.3 -0.2 0.6 -0.5 1.9
Trunk fat-free mass 0.9 5.2 9.9 2.3 2.4 2.2 0.4 -2.7 3.1 2.6 -0.3 -2.6
Hip circumference 0.1 0.3 0.9 0.7 0.4 0.4 -0.1 0.2 0.9 0.8 -0.4 -0.2
Time employed in main current job 1.6 1.9 4.1 -1.5 -1.3 -0.4 -0.6 -1.3 -1.9 -2.0 -1.7 -0.1
Alcohol intake versus 10 years previously 1.2 1.8 8.8 1.2 0.8 0.2 -0.1 -0.6 1.2 3.0 1.8 -0.0
Father’s age at death 0.6 0.8 2.0 -0.8 -0.8 -0.6 -0.7 0.8 -0.7 -1.3 -1.4 -0.7
Worrier / anxious feelings 0.2 0.5 1.9 -0.4 -0.7 -0.4 0.3 -1.4 -1.0 -0.1 -0.4 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.1 -0.1 -0.4 -0.2 0.5 -0.4 -1.1 0.4 0.6 0.1
Falls in the last year 2.4 3.2 5.0 1.7 1.6 2.1 1.4 -2.2 2.0 1.4 2.1 -1.1
Hair/balding pattern: Pattern 3 2.3 3.4 8.0 1.6 1.8 2.7 1.6 -1.1 0.6 -2.3 0.0 -2.8
Number of live births 0.5 0.8 1.5 -0.7 -0.8 -1.1 -1.2 1.1 -1.2 -0.2 -0.6 0.1
Forced expiratory volume in 1-second (FEV1) 0.3 0.8 4.3 0.3 0.5 -0.0 -0.1 -0.1 0.8 0.6 -1.3 -2.1
Pulse rate 0.5 0.9 2.9 -0.8 -0.9 -1.0 -0.4 1.0 -0.7 1.7 0.7 1.0
Happiness 1.2 1.5 4.7 1.3 0.9 0.4 0.7 -0.7 1.5 2.2 1.5 0.8
Noisy workplace 0.4 0.5 1.4 -0.7 -0.8 -0.6 -1.2 0.2 -0.9 -0.0 -0.1 0.9
Qualifications: A levels/AS levels or equivalent 0.9 2.0 3.4 1.6 1.5 1.4 1.4 -1.8 1.6 0.6 0.8 -1.6
Serious illness, injury or assault of a close relative in last 2 years 2.1 2.4 5.7 1.9 1.7 1.5 1.0 -0.4 1.4 2.4 2.0 -0.8
Mouth/teeth dental problems: Dentures 0.4 0.7 2.9 0.3 0.1 0.7 1.5 -0.4 -0.2 0.1 1.7 -0.3
Asthma 1.2 2.4 5.4 1.4 2.0 2.3 2.1 -1.4 1.0 -0.5 1.5 0.2
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.6 -0.2 -0.4 -0.3 0.1 0.0 -0.3 0.9 0.8 1.3
Medication: Cholesterol lowering 1.6 2.5 4.3 -2.1 -2.0 -2.0 -1.7 -0.4 -1.9 -0.7 -1.0 1.3
Depression (self-reported) 0.2 0.3 2.0 0.3 0.0 0.2 0.0 -0.2 -0.4 0.3 0.3 -1.4
Medication: Lansoprazole 0.3 0.3 0.8 -0.3 -0.5 -0.7 -0.3 0.8 0.0 0.5 -0.3 0.9
Prospective memory result 1.9 2.4 4.0 -1.6 -1.9 -1.8 -2.0 1.5 -1.5 -0.4 -1.4 1.2
Lung cancer (father) 0.5 0.6 1.8 -0.9 -0.8 -0.8 -0.3 1.3 -0.4 -1.0 -0.3 0.1
Illnesses of mother 1.7 2.1 5.6 1.5 1.5 2.3 1.2 -0.6 1.0 -0.8 0.4 -2.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 3.3 0.7 0.8 0.3 0.5 0.3 0.9 0.3 -0.8 -1.8
Pulse wave Arterial Stiffness index 1.0 1.1 4.6 -0.5 -1.3 -2.1 -0.6 0.4 -1.0 0.6 -1.1 0.7
Impedance of arm (left) 0.7 3.2 7.8 -1.4 -2.3 -2.8 -1.8 0.7 -1.6 2.2 1.0 1.2
Arm fat mass (right) 0.3 1.3 4.7 -0.1 -0.5 -1.0 -1.1 2.2 0.8 1.5 -0.5 1.0
Trunk predicted mass 0.9 5.3 10.4 2.4 2.5 2.2 0.5 -2.7 3.2 2.6 -0.2 -2.5
Standing height 1.2 12.1 48.7 2.8 1.9 0.8 -0.7 -5.0 3.7 7.0 1.6 -2.7
Length of working week for main job 0.3 0.4 1.7 -0.2 -0.3 -0.6 -0.2 0.1 -0.3 0.9 0.2 1.3
Exposure to tobacco smoke at home 0.1 0.1 0.4 0.1 0.1 0.5 0.6 0.1 -0.6 -0.2 0.4 -0.5
Breastfed as a baby 0.7 0.8 2.6 0.6 0.8 0.6 0.9 1.3 0.8 -1.6 -0.0 -0.7
Tense / ‘highly strung’ 2.1 3.5 7.3 -2.3 -2.4 -2.2 -1.4 -0.2 -2.7 -0.0 -1.7 1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.8 0.0 -0.9 -0.5 -0.1 -0.0 0.0 -0.3 0.4 0.4
Hair/balding pattern: Pattern 4 4.8 11.7 42.1 3.5 2.6 0.3 1.2 0.5 5.1 6.5 4.1 -0.0
Birth weight of first child 0.8 1.4 7.5 0.3 0.2 1.1 -1.0 -2.7 -0.6 -1.2 -0.1 -1.1
Peak expiratory flow (PEF) 0.8 1.8 9.5 -0.7 -0.3 -0.8 -0.3 1.0 -0.2 -1.0 -3.1 -1.9
Pulse wave reflection index 0.4 0.5 1.4 -0.4 -0.5 -1.1 -1.1 -0.4 -0.2 -0.6 -1.2 0.2
Ever highly irritable/argumentative for 2 days 2.8 3.4 10.4 -1.3 -1.9 -2.4 -1.4 -0.5 -0.9 3.2 1.2 2.2
Loud music exposure frequency 0.1 0.2 0.5 0.2 0.0 -0.0 0.4 0.7 0.4 0.4 0.1 -0.6
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 2.6 0.4 0.3 0.7 0.3 -0.9 0.1 -0.9 -0.3 -1.6
Mouth/teeth dental problems: Bleeding gums 1.7 2.2 6.7 -1.7 -1.6 -1.6 -2.6 0.6 -1.1 0.3 -1.4 1.5
Blood clot in the leg (DVT) 2.9 3.7 7.3 -2.0 -2.5 -2.7 -2.1 1.9 -1.8 -0.3 -1.9 0.9
Medication: Paracetamol 0.6 1.0 5.6 0.5 -0.0 -0.3 -0.4 0.2 0.7 2.4 1.4 0.7
Headache pain in last month 1.7 3.0 5.0 -2.0 -1.8 -2.2 -1.9 2.0 -1.5 0.5 -1.0 1.9
Medication for cholesterol, blood pressure or diabetes 0.1 0.1 0.3 0.5 0.1 0.5 -0.2 0.1 0.2 0.2 0.1 -0.4
Glaucoma (self-reported) 0.5 0.6 1.7 0.9 0.4 -0.3 0.7 -0.4 1.3 1.1 1.0 0.1
Gout (self-reported) 0.4 0.5 2.2 -0.3 -0.0 0.4 0.3 1.0 -1.0 -1.5 -0.2 -0.5
Hypothyroidism/myxoedema (self-reported) 3.9 7.5 17.3 -2.7 -3.0 -2.0 -2.4 1.3 -3.1 -4.2 -3.5 -0.2
Medication: Amlodipine 0.8 1.1 3.5 -0.8 -0.0 0.1 1.7 -0.2 -0.9 -1.9 -1.2 0.8
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.2 0.6 0.9 1.5 1.2 -0.0 0.1 -0.9 0.7 -0.9
Birth weight 3.1 6.8 11.4 2.7 3.0 3.3 2.6 -3.4 1.9 1.6 3.0 -0.8
Chronic bronchitis/emphysema (mother) 1.4 1.6 4.7 -0.8 -0.4 -0.3 1.6 1.1 -2.2 -1.2 -0.5 1.9
High blood pressure (siblings) 0.4 0.6 2.7 0.7 0.9 0.4 1.7 -0.1 1.0 -0.2 0.6 0.1
Forced vital capacity (FVC), Best measure 2.1 7.5 13.5 3.2 3.3 2.3 2.0 -1.7 3.7 2.4 2.1 -3.2
Body fat percentage 0.8 3.2 7.8 -0.9 -1.7 -2.4 -2.0 2.8 -0.2 2.0 0.0 1.9
Leg fat percentage (right) 0.4 1.5 4.3 -0.2 -0.8 -1.4 -0.9 2.0 -0.0 2.1 0.5 1.3
Arm fat-free mass (right) 0.5 2.4 5.5 1.4 1.5 1.3 -0.3 -1.7 2.3 2.0 -0.6 -1.8
Exposure to tobacco smoke outside home 0.4 0.5 1.5 -0.8 -0.9 -0.3 -0.3 -1.1 -1.2 0.1 0.0 0.9
Comparative body size at age 10 1.2 3.3 9.7 -0.8 -1.5 -1.8 -3.1 2.2 -0.5 1.5 -1.1 2.2
Number of full brothers 2.6 3.3 6.0 2.4 2.5 2.0 1.7 -0.0 2.1 1.0 2.2 -1.0
Worry too long after embarrassment 0.7 1.2 3.8 -1.5 -1.4 -0.9 -0.4 -0.9 -2.0 -0.1 -1.1 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.3 0.6 0.1 0.6 -0.3 -1.1 0.4 -0.2 0.9 -0.8
Wheeze or whistling in the chest in last year 0.8 1.5 5.7 1.0 1.0 1.5 2.4 -0.5 0.1 0.6 1.5 -0.4
Number of children fathered 0.9 1.0 2.0 1.2 1.4 1.3 1.2 -0.5 1.0 -0.1 0.5 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 1.6 0.1 0.5 0.2 -0.2 1.3 0.2 -0.2 0.2 0.4
Age at first live birth 0.3 0.5 1.8 0.1 0.6 0.5 -0.4 -1.4 1.3 -0.6 -0.0 -0.3
Pulse wave peak to peak time 1.3 1.5 4.8 0.9 1.6 2.2 0.6 -0.8 1.5 0.2 1.4 -0.8
Health satisfaction 0.4 0.6 3.1 -0.1 -0.3 -0.6 1.1 -0.3 0.0 1.8 0.6 0.3
Shortness of breath walking on level ground 1.7 2.0 4.6 1.7 1.2 1.2 1.8 0.9 1.1 1.3 2.1 -0.5
Qualifications: College or University degree 1.8 5.7 14.7 2.9 2.7 2.4 0.6 -1.8 3.8 1.8 1.8 -2.4
Eye problems/disorders: None of the above 1.6 1.8 4.3 1.3 1.8 2.1 1.1 -0.8 1.3 0.3 0.7 -1.7
Mouth/teeth dental problems: Loose teeth 0.5 0.5 1.4 -0.9 -0.9 0.1 -0.4 -0.4 -1.2 -1.0 -0.4 0.6
Emphysema/chronic bronchitis 3.7 4.2 9.8 2.0 2.1 2.6 2.1 -1.6 1.8 1.0 3.1 -1.4
Medication for pain relief, constipation, heartburn 0.6 1.1 3.1 0.4 0.8 0.9 0.1 -0.9 0.6 -1.6 -1.2 -1.8
Neck or shoulder pain in last month 1.8 2.5 4.4 -1.8 -2.1 -1.8 -1.7 0.7 -1.6 -0.7 -1.5 1.8
Medication: Blood pressure 0.8 1.4 4.4 1.1 1.6 1.0 2.1 -0.6 1.4 0.6 1.0 -0.3
Angina (self-reported) 0.2 0.3 1.1 0.4 0.4 0.2 -0.2 -1.1 -0.0 0.0 0.0 -0.9
Migraine (self-reported) 2.2 2.8 5.1 -1.8 -1.4 -1.9 -1.8 2.2 -0.9 -0.8 -2.2 1.4
Medication: Ibuprofen 0.7 0.8 3.0 -0.9 -0.9 -0.7 -0.2 1.0 -1.1 0.0 -0.1 1.7
Medication: Allopurinol 0.2 0.3 1.1 0.2 0.3 0.6 -0.0 -0.2 -0.6 -0.6 0.2 -1.1
Medication: Omeprazole 0.7 0.8 3.5 -0.4 -0.7 -1.1 -0.0 1.0 -0.3 1.9 0.0 0.8
Medication: Seretide 50 evohaler 10.2 11.8 18.6 4.0 4.3 4.2 4.3 -0.4 3.3 1.8 4.1 -1.9
Mean time to correctly identify matches 0.6 1.1 5.2 -1.1 -0.6 -0.9 0.9 1.0 -0.3 -0.1 -0.5 2.3
Heart disease (mother) 0.4 0.5 2.4 -0.1 -0.6 -1.0 -0.2 0.4 0.4 0.3 0.5 1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 4.7 -0.6 -0.5 0.2 0.1 0.4 -0.9 -2.2 -1.1 0.6
Whole body fat mass 0.5 2.1 6.2 -0.4 -1.1 -1.8 -1.7 1.9 0.5 2.5 -0.3 1.2
Leg fat mass (right) 0.4 1.5 6.2 0.1 -0.4 -1.2 -1.1 1.7 0.7 2.5 -0.0 1.0
Arm predicted mass (right) 0.4 2.1 5.1 1.3 1.4 1.1 -0.5 -1.4 2.2 1.9 -0.8 -1.5
Pulse rate, automated reading 0.3 1.1 2.4 -0.9 -0.9 -1.2 0.3 1.2 -0.4 1.1 1.2 1.5
Alcohol intake frequency. 1.2 2.8 5.3 -1.7 -2.0 -1.5 -0.5 1.0 -2.3 -1.2 -1.6 2.3
Comparative height size at age 10 1.1 6.2 33.9 1.5 0.2 -1.1 -0.7 -2.6 2.7 5.8 1.9 0.4
Number of full sisters 1.1 1.4 3.3 1.1 0.9 -0.0 0.2 0.5 1.6 1.8 1.8 1.1
Suffer from ‘nerves’ 2.7 4.2 10.8 -2.4 -2.5 -1.6 -1.1 0.1 -3.3 -2.2 -1.9 1.4
Overall health rating 0.4 0.9 2.0 -0.6 -1.3 -1.2 0.3 0.5 -0.5 1.4 0.7 1.2
Chest pain or discomfort 2.2 3.2 8.0 1.9 1.6 2.2 2.0 -0.4 0.8 0.7 2.8 -2.2
Had major operations 1.2 1.4 2.4 1.2 1.3 1.1 1.0 1.0 1.1 1.4 1.5 -0.8
Age at last live birth 0.5 0.7 2.3 -0.8 -0.6 -1.2 -1.5 0.0 0.0 0.7 -0.3 0.7
Family relationship satisfaction 1.0 1.2 5.1 0.8 0.5 0.2 -0.0 -1.8 0.6 2.3 0.8 0.5
Leg pain on walking 0.7 0.9 3.2 1.1 0.5 0.4 0.6 0.2 0.6 1.5 1.8 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 3.3 0.9 1.1 0.6 -0.6 -0.3 0.8 1.8 -0.2 -0.4
Commuting to job workplace: Car/motor vehicle 0.7 0.8 4.4 0.4 0.9 0.8 2.1 -1.1 0.3 0.2 0.6 0.1
Illness, injury, bereavement, stress in last 2 years 0.9 1.2 4.1 0.8 0.6 1.2 -0.5 -0.3 0.7 -2.0 -0.1 -1.7
Medication: Aspirin 0.3 0.4 1.3 -0.2 -0.7 -0.9 -0.7 0.5 -0.4 0.5 0.6 1.1
Supplements: Vitamin C 1.2 1.4 2.9 -1.5 -1.4 -0.7 -1.0 0.3 -1.1 -1.4 -1.0 1.7
Knee pain experienced in last month 1.0 1.6 4.7 -1.2 -1.1 -1.2 -1.4 0.2 -2.2 0.5 -1.3 1.2
Hypertension (Self-reported) 0.3 0.8 2.6 -0.3 0.1 -0.8 0.9 1.0 1.1 0.4 0.4 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.1 2.3 1.3 1.2 0.9 0.9 -0.1 1.4 1.1 1.5 -0.0
Illnesses of father: Heart disease 0.0 0.0 0.2 -0.1 -0.1 -0.0 0.4 -0.1 0.1 0.1 -0.1 0.0
Illnesses of siblings: Diabetes 0.9 1.2 7.0 0.4 0.7 0.8 2.6 0.5 -0.6 -0.4 0.9 0.8
Smoking status: Previous 1.4 2.1 8.4 -1.5 -1.2 -0.3 -0.7 -1.5 -1.2 -2.9 -1.4 0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 2.4 0.2 0.3 0.2 -1.5 -1.3 0.4 1.6 -0.5 -0.6
Whole body fat-free mass 0.5 3.0 6.4 1.6 1.7 1.6 -0.2 -1.9 2.5 2.0 -0.7 -2.0
Leg fat-free mass (right) 0.2 1.1 2.4 0.7 1.0 1.0 -0.7 -0.6 1.6 0.9 -1.1 -1.3
Arm fat percentage (left) 0.6 2.5 12.6 -0.8 -1.2 -1.6 -1.3 3.5 -0.2 0.7 -0.4 1.6
Average weekly red wine intake 0.8 1.1 3.4 0.8 1.1 1.9 0.1 -0.7 0.1 -0.1 1.1 -1.8
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.5 0.6 0.6 0.6 1.2 -0.8 0.4 0.8 1.1 0.2
Mood swings 2.2 3.9 7.9 -2.4 -2.6 -2.3 -1.9 -0.2 -2.8 -0.9 -2.1 1.0
Loneliness, isolation 1.8 2.5 6.1 -1.7 -1.8 -1.8 -1.4 1.1 -2.5 0.1 -1.3 1.4
Long-standing illness, disability or infirmity 0.2 0.3 1.9 -0.3 -0.2 0.0 0.7 -1.4 -0.3 0.1 -0.4 -0.0
Ever had bowel cancer screening 0.1 0.1 0.5 0.2 0.4 0.3 0.2 -0.1 0.6 -0.1 0.4 0.7
Diabetes diagnosed by doctor 0.2 0.3 0.9 -0.4 -0.6 -0.8 0.3 0.1 -0.6 0.9 0.2 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 1.4 -0.3 -0.5 -0.9 -1.2 -0.7 -0.1 0.9 0.1 -0.2
Friendships satisfaction 0.5 0.6 1.7 0.9 0.6 0.5 0.2 -1.2 0.5 1.3 0.3 0.4
Qualifications: nursing, teaching 1.0 1.6 3.1 -1.8 -1.3 -1.1 -1.1 0.1 -1.2 -1.5 -1.6 0.9
Commuting to job workplace: Walk 0.1 0.1 0.4 0.1 -0.1 0.3 -0.4 0.1 0.4 -0.2 0.0 -0.6
Eye problems/disorders: Cataract 1.4 1.6 3.5 -1.4 -1.4 -1.6 -0.9 1.9 -1.0 -0.8 -0.8 1.0
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.4 0.4 0.1 0.6 0.0 -1.0 0.1 -1.2 -0.5 -0.1
Medication for cholesterol 1.6 2.4 7.5 0.8 1.0 2.0 0.4 -2.4 -1.1 -1.0 -0.3 -2.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 2.6 -0.0 -0.1 0.3 0.8 -0.7 -0.2 1.2 1.6 0.6
Back pain experienced in last month 1.1 1.6 5.2 -1.2 -1.7 -1.5 -2.3 -0.1 -1.0 0.8 -0.6 0.9
Mineral and other dietary supplements 1.0 1.3 4.0 -1.2 -0.9 -1.4 1.2 0.2 -0.8 -0.5 -1.0 2.0
Breast cancer (self-reported) 0.6 0.7 1.6 -0.5 -0.2 -0.3 0.8 1.3 -1.1 -1.2 -0.5 -0.5
Asthma (self-reported) 1.4 2.8 6.4 1.7 2.2 2.5 2.2 -1.3 1.2 -0.3 1.7 -0.1
Osteoporosis (self-reported) 2.0 2.4 6.1 1.7 1.6 1.8 2.2 -0.2 0.4 0.3 1.4 -2.5
Osteoarthritis (self-reported) 1.0 1.3 2.3 -1.4 -1.5 -1.5 -1.1 0.4 -1.1 -0.8 -1.1 0.9
Medication: Aspirin 0.7 1.0 2.4 -0.8 -1.3 -1.3 -0.8 0.6 -1.0 0.5 -0.0 1.5
Medication: Gliclazide 1.0 1.1 2.0 -1.3 -1.1 -0.7 -1.2 0.4 -1.3 -1.0 -1.4 -0.6
Illnesses of father: None of the above (group 1) 0.5 0.6 1.2 1.0 1.1 0.7 0.9 1.0 0.8 0.0 0.7 -0.2
Smoking status: Current 0.7 1.1 5.9 0.9 0.3 -0.6 -0.2 0.9 0.2 2.4 1.3 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.5 -0.6 -0.6 -0.4 -0.4 0.2 0.2 -1.2 -0.8 -0.6
Whole body water mass 0.5 2.8 6.1 1.6 1.7 1.6 -0.2 -1.9 2.5 1.8 -0.8 -1.9
Leg predicted mass (right) 0.2 1.1 2.6 0.7 1.0 1.0 -0.7 -0.7 1.6 0.9 -1.1 -1.2
Arm fat mass (left) 0.3 1.3 4.6 -0.2 -0.5 -1.1 -1.1 2.1 0.8 1.6 -0.4 1.0
Number of self-reported non-cancer illnesses 0.4 0.7 3.2 0.1 0.1 0.2 1.8 -0.6 0.6 0.1 1.2 0.8
Average weekly champagne plus white wine intake 2.3 3.1 10.9 -1.2 -1.8 -1.9 -1.1 3.3 -1.1 -1.1 -1.4 1.7
Miserableness 0.4 0.7 3.2 -0.6 -0.8 -0.5 -0.1 0.2 -1.8 -0.4 -0.9 -0.8
Guilty feelings 0.3 0.5 1.6 -0.6 -0.3 -0.5 -0.7 0.4 -1.1 1.3 -0.1 -0.1
Wears glasses or contact lenses 0.5 0.6 3.5 -0.6 -0.7 -0.5 0.4 0.7 0.3 0.1 0.1 1.9
Ever taken oral contraceptive pill 0.5 0.6 2.8 -0.0 0.1 0.9 -0.3 -1.7 -0.4 -1.0 -0.1 -0.3
Hearing aid user 0.6 0.7 1.7 1.1 1.3 1.2 0.3 -0.1 0.4 0.3 0.8 -1.1
Mother’s age at death 0.6 0.8 1.9 -1.0 -1.2 -1.4 -1.2 -0.6 -0.5 0.2 -0.8 -0.3
Financial situation satisfaction 0.5 0.7 3.5 0.4 0.2 0.1 0.1 -0.9 0.1 1.9 1.0 0.7
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.9 0.0 0.1 0.6 -0.0 -0.8 -0.3 -1.0 -0.7 -0.2
Commuting to job workplace: Public transport 0.8 1.0 3.3 1.3 0.8 0.6 0.3 -0.0 1.8 0.2 1.5 0.5
Eye problems/disorders: Glaucoma 0.3 0.4 0.9 0.4 -0.2 -0.8 0.3 -0.2 0.9 0.8 0.7 0.9
Medication: Blood pressure 1.8 3.5 12.5 -1.5 -1.6 -2.6 -0.7 2.5 0.4 0.2 -0.6 3.5
Pain type(s) experienced in last month: Hip pain 2.5 3.1 7.8 -2.1 -1.9 -1.4 -1.7 0.7 -2.8 -1.3 -1.7 1.4
Supplements: Fish oil (including cod liver oil) 0.8 1.1 5.7 0.4 0.5 1.4 -0.8 -0.2 -0.7 -0.6 0.0 -2.4
High cholesterol (Self-reported) 1.0 1.8 4.4 -1.4 -1.7 -2.1 -0.6 1.0 -1.1 -0.5 -0.0 2.1
Medication: Bendroflumethiazide 1.1 1.6 4.6 0.6 0.6 -0.8 0.2 1.6 2.2 1.4 1.1 1.6
Medication: Paracetamol 0.3 0.4 1.8 -0.2 -0.3 -0.3 -0.4 -0.0 -0.2 1.4 0.5 1.0
Medication: Lisinopril 1.5 1.9 3.6 1.5 1.8 0.7 1.6 0.6 1.5 1.9 1.7 -0.1
Medication: Atorvastatin 0.3 0.4 1.2 0.3 0.2 -0.4 0.6 -0.7 -0.1 1.1 0.7 0.6
Illnesses of father: High blood pressure 3.5 4.3 8.1 -2.7 -2.4 -2.1 -1.7 1.6 -1.8 -1.6 -2.8 1.6
Alcohol drinker status: Never 0.6 0.7 2.2 -0.9 -0.6 -0.2 0.2 -0.1 -1.5 -0.5 -1.2 -1.1
Ever smoked 1.2 2.0 3.3 -1.7 -1.8 -1.5 -1.7 0.2 -1.2 -1.2 -1.1 1.7
Basal metabolic rate 0.5 2.7 6.2 1.6 1.6 1.3 -0.3 -1.5 2.5 2.3 -0.5 -1.7
Leg fat percentage (left) 0.7 2.5 6.6 -0.7 -1.3 -1.9 -1.4 2.6 -0.1 1.9 0.2 2.1
Arm fat-free mass (left) 0.6 2.9 7.4 1.7 1.7 1.3 0.0 -1.9 2.7 2.4 -0.5 -1.3
Number of operations (self-reported) 0.6 0.9 2.5 -0.9 -1.2 -1.0 -0.8 1.6 0.1 -0.4 -0.5 1.0
Average weekly beer plus cider intake 0.7 1.1 2.9 0.9 0.9 0.8 0.1 -0.6 1.0 1.6 1.7 -0.7
Irritability 3.3 5.7 11.3 -2.8 -2.9 -2.5 -1.8 1.1 -3.4 -0.9 -2.3 2.6
Risk taking 0.4 0.6 1.9 0.8 0.6 -0.0 -0.1 0.2 0.6 1.4 0.8 -1.3
Ever had prostate specific antigen (PSA) test 0.5 0.6 2.1 -0.1 0.1 0.8 0.8 -1.0 0.0 -1.5 0.7 -0.4
Fractured/broken bones in last 5 years 0.3 0.3 1.4 -0.3 -0.3 -0.5 -0.4 1.0 -0.0 1.2 -0.1 -0.2
Age started oral contraceptive pill 0.1 0.2 0.4 -0.1 0.3 0.5 0.6 0.4 0.4 -0.6 0.3 -0.0
Diastolic blood pressure, automated reading 0.3 1.0 2.8 -0.8 -0.8 -1.4 -0.5 1.5 0.5 -0.6 -1.7 0.3
Ever depressed for a whole week 1.7 2.1 4.5 -1.5 -2.1 -2.0 -1.3 1.3 -0.7 0.2 -0.9 1.7
Unable to work because of sickness or disability 0.1 0.2 0.9 0.1 0.4 0.3 1.0 0.4 -0.1 -0.1 0.3 0.3
Commuting to job workplace: Cycle 1.1 1.4 2.7 -1.6 -1.0 -1.0 -1.6 -0.2 -1.1 -0.1 -1.1 1.6
Myopia 4.1 5.9 16.0 -3.1 -2.3 -1.5 -1.3 0.9 -2.5 -3.2 -4.0 1.2
Vascular/heart problems diagnosed by doctor 0.3 0.8 3.2 0.4 0.3 1.2 -0.6 -0.9 -0.8 -0.7 -0.6 -1.8
Cholesterol lowering medication 0.7 1.1 3.3 0.2 -0.4 -1.1 0.5 1.6 0.5 0.9 1.1 1.8
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 3.6 -0.0 -0.4 -1.0 0.4 1.8 -0.1 1.9 0.2 0.9
Pain experienced in last month 2.2 3.7 5.4 2.1 2.2 2.3 2.1 -2.0 2.1 -0.7 1.3 -1.8
Supplements: Calcium 0.2 0.2 0.6 0.1 0.1 0.2 0.4 -0.4 -0.5 -0.8 -0.5 0.1
Basal cell carcinoma (self-reported) 2.6 3.0 5.6 2.1 2.4 2.1 2.1 -0.9 1.8 -0.0 1.1 -1.8
Heart attack/myocardial infarction (self-reported) 2.4 3.1 6.4 -2.0 -2.0 -2.0 -1.6 -0.8 -2.5 -0.2 -1.6 2.0
Deep venous thrombosis (DVT) (self-reported) 3.6 4.6 8.7 -2.2 -2.8 -2.9 -2.3 2.3 -2.1 -0.4 -2.2 1.0
Heart disease (siblings) 0.2 0.2 0.7 -0.2 -0.0 -0.2 0.8 -0.6 -0.5 0.6 0.5 -0.4
Alcohol drinker status: Previous 1.4 1.6 7.0 -1.0 -1.4 -1.1 0.6 -0.6 -1.6 -0.2 -0.3 2.6
Pack years of smoking 1.1 1.7 3.9 1.6 1.1 0.8 1.5 -0.3 1.0 1.8 2.0 0.1
Impedance of whole body 0.8 4.0 11.4 -1.1 -2.3 -3.0 -1.5 -0.3 -1.3 3.4 1.7 1.6
Leg fat mass (left) 0.5 1.9 5.3 -0.3 -0.7 -1.5 -1.5 1.9 0.6 2.3 -0.4 1.4
Arm predicted mass (left) 0.5 2.7 7.2 1.5 1.6 1.2 -0.2 -1.9 2.7 2.3 -0.5 -1.2