Hub : Genes

RLTPR

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0376 0.0245 0.0032 0.000 0.001 0.001 0.003 0.00 0.3200 0.2100 0.260 0.11 0.3000
2 TCGA Lung Adenocarcinoma 0.0254 0.0154 0.0084 0.022 0.017 0.011 NA 0.02 0.0012 0.0039 0.017 NA 0.0018

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 3.5 5.5 6.5 2.6 -2.1
Bipolar Disorder or Schizophrenia 4.8 11.8 14.4 3.0 -3.8
Depressed Affect (Nagel 2018) 0.8 1.6 3.1 -1.8 -0.3
Depression (Nagel 2018) 0.8 1.3 2.5 -1.6 0.1
Intelligence (Savage-Jansen 2018) 0.4 1.1 2.0 1.4 0.4
Neuroticism (Nagel 2018) 0.2 0.5 0.8 -0.9 -0.5
Schizophrenia (2018) 3.2 6.6 10.0 1.8 -3.2
Schizophrenia vs Biploar Disorder 0.7 0.9 1.8 -1.4 -0.2
Worry (Nagel 2018) 0.3 0.6 0.8 0.6 -0.9
Alzheimer’s Disease (in mother) 0.9 1.1 2.0 -0.4 1.4
Alzheimer’s Disease (in father) 1.9 2.1 2.3 1.5 -1.4
Alzheimer’s Disease (including proxy) 0.1 0.1 0.2 0.3 0.5
Crohns Disease (2017) 0.3 0.6 1.2 -0.0 1.1
Irritable Bowel Disease (IBD) 0.2 0.5 0.9 -0.3 0.9
Ulcerative Colitis (UC) 0.0 0.0 0.0 -0.2 0.1
Major Depression (MDD) 1.7 2.0 3.8 1.9 -0.5
Reaction Time 0.0 0.1 0.1 -0.3 0.2
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.3 1.5 0.3
Breast Cancer 0.3 0.7 1.4 -0.2 1.2
Ovarian Cancer 2.6 3.4 4.4 -1.6 2.1
Prostate Cancer 1.1 1.6 2.7 -0.7 1.7
Age at First Birth 0.8 1.2 1.9 1.4 -0.7
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.2 1.6 3.2 1.8 0.0
Coronary Artery Disease (CAD) 0.6 0.7 1.5 -1.2 0.0
Crohns Disease (2012) 0.5 0.8 1.5 -0.2 1.2
Mean Putamen Volume 2.1 2.4 3.5 1.9 -1.1
Fasting Glucose 3.3 4.0 7.5 -0.7 2.7
HbA1C 0.2 0.2 0.4 0.6 0.1
HDL Cholesterol 1.1 1.8 3.6 -1.9 0.0
LDL Cholesterol 0.3 0.5 1.0 1.0 0.0
Lupus 0.1 0.2 0.2 -0.4 -0.5
Neuroticism (2016) 0.1 0.2 0.4 -0.6 -0.1
Primary Biliary Cirrhosis 1.3 1.8 3.1 -1.8 0.7
Rheumatoid Arthritis 0.1 0.1 0.2 0.1 -0.5
Schizophrenia (2014) 1.7 3.8 6.5 1.0 -2.6
Triglycerides 0.0 0.0 0.1 0.3 0.0
Type 2 Diabetes (T2D) (2012) 1.5 1.7 3.4 1.9 0.0
Ulcerative Colitis 0.2 0.3 0.3 -0.6 0.6
Blood Eosinophil Count 3.1 24.0 41.1 -6.4 2.6
Blood Platelet Count 1.3 14.9 15.1 -3.9 3.9
Blood Red Count 3.9 38.0 46.1 5.5 -6.8
Blood White Count 2.1 15.5 20.0 -3.3 4.5
Heel T-Score 3.0 24.0 28.1 4.5 -5.3
BMI 0.3 1.7 1.9 1.4 -1.2
Height 4.8 92.8 118.8 -10.9 8.2
Waist Hip Ratio (WHR) 7.1 32.1 35.9 -6.0 5.3
Systolic Blood Pressure 0.1 0.3 0.6 0.3 -0.8
Smoking Status 0.3 0.8 1.6 -1.3 -0.2
Allergy or Eczema 0.1 0.2 0.3 0.6 -0.4
Cardiovascular Disease 0.6 1.9 2.5 -1.1 1.6
Hypothyroidism (self reported) 10.0 23.0 23.1 4.8 -4.8
Respiratory disease 0.3 0.7 1.4 1.2 -0.1
Type 2 Diabetes (T2D) (2018) 0.4 0.8 0.9 -0.8 0.9
Lung FEV1/FVC ratio 7.9 40.1 66.9 3.6 -8.2
Lung FVC 0.7 3.5 6.2 2.5 0.9
Neuroticism 0.3 0.7 0.9 -0.7 -0.9
Chronotype (morning person) 3.3 7.7 8.4 -2.6 2.9
Hair Pigment 0.4 10.1 11.8 2.9 -3.4
Tanning 0.2 2.8 3.9 -2.0 1.3
Hand grip strength (left) 0.0 0.1 0.1 -0.2 0.3
Number of treatments/medications taken 0.5 0.8 0.9 -0.9 0.9
Average weekly spirits intake 1.3 1.6 2.4 -1.5 0.9
Sensitivity / hurt feelings 0.9 1.6 2.1 -1.4 1.0
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.2 -0.1 -0.4
Hearing difficulty/problems: Yes 2.2 3.3 6.4 2.5 -0.5
Relative age of first facial hair 0.0 0.1 0.1 -0.1 0.4
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.2 0.4 0.2
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.7 -0.5 0.8
Ever had hysterectomy (womb removed) 1.6 1.8 3.1 -1.8 0.7
Systolic blood pressure, automated reading 0.2 0.7 1.0 1.0 -0.7
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 -0.2 -0.5
Angina 0.0 0.1 0.1 -0.4 0.0
Medication for hormone replacement therapy 0.3 0.3 0.4 -0.4 0.7
Vitamin and mineral supplements 0.3 0.5 0.8 0.4 0.9
Supplements: Zinc 0.5 0.5 1.1 -0.0 -1.0
Medication: Co-codamol 0.3 0.4 0.6 0.5 -0.8
Medication: Metformin 0.2 0.3 0.4 0.4 -0.6
Diabetes (father) 0.0 0.1 0.1 -0.1 -0.3
Diabetes (mother) 2.3 2.9 4.6 -2.1 1.1
Severe depression (siblings) 0.6 0.7 1.3 -1.2 -0.1
Pack years adult smoking proportion 2.6 3.9 4.0 -2.0 2.0
Impedance of leg (right) 4.8 23.3 28.7 -5.4 4.2
Leg fat-free mass (left) 0.5 2.4 2.8 -1.7 1.4
Trunk fat percentage 2.0 8.1 10.4 -3.2 2.4
Hand grip strength (right) 0.0 0.1 0.1 -0.3 0.0
Townsend deprivation index at recruitment 0.1 0.2 0.3 0.5 0.2
Current tobacco smoking 6.0 9.8 14.0 -3.7 2.4
Average weekly fortified wine intake 0.2 0.2 0.3 -0.2 -0.6
Maternal smoking around birth 1.5 2.2 3.4 -1.8 1.0
Fed-up feelings 0.2 0.4 0.5 -0.7 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.7 -0.8 -0.3
Relative age voice broke 0.4 0.6 1.1 1.1 -0.3
Taking other prescription medications 0.0 0.0 0.0 -0.0 0.0
Age when periods started (menarche) 0.0 0.1 0.1 0.4 0.1
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 0.7 0.8 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.9 1.9 2.4 1.2 -1.5
Tinnitus: Yes, but not now, but have in the past 1.1 1.1 2.2 0.3 -1.5
Qualifications: CSEs or equivalent 5.7 7.6 9.3 2.4 -3.0
Serious illness, injury or assault to yourself 3.3 4.0 4.0 -2.0 2.0
High blood pressure 0.3 0.7 1.4 0.2 1.2
Hayfever, allergic rhinitis or eczema 0.7 1.5 2.0 1.0 -1.4
Multivitamins +/- minerals 0.2 0.3 0.5 -0.2 -0.7
Stomach or abdominal pain in last month 0.1 0.2 0.3 -0.2 -0.6
Supplements: Glucosamine 1.8 2.4 3.0 -1.3 1.7
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.7 -0.1 -0.8
Medication: Atenolol 0.3 0.4 0.6 -0.6 0.7
Medication: Levothyroxine sodium 6.8 11.6 12.7 3.2 -3.6
Sitting height 0.8 5.5 7.2 -2.7 2.0
Chronic bronchitis/emphysema (father) 0.1 0.1 0.1 -0.1 0.3
High blood pressure (mother) 0.6 0.8 1.5 1.2 -0.4
Body mass index (BMI) 0.1 0.5 0.6 0.8 -0.6
Impedance of leg (left) 4.5 21.8 28.6 -5.3 3.9
Leg predicted mass (left) 0.5 2.7 3.1 -1.8 1.5
Trunk fat mass 2.9 12.6 15.7 -4.0 3.1
Waist circumference 2.8 10.3 11.1 -3.3 3.1
Number of incorrect matches in round 1.5 2.5 4.8 -2.2 0.4
Past tobacco smoking 1.0 1.8 2.5 -1.0 1.6
Alcohol usually taken with meals 4.0 6.5 8.1 2.2 -2.9
Nervous feelings 2.2 4.1 5.0 2.2 -1.8
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.0 1.5 -1.2 -0.7
Hearing difficulty/problems with background noise 1.1 1.7 3.5 1.9 0.2
Hair/balding pattern: Pattern 2 0.1 0.1 0.1 -0.3 0.2
Had menopause 0.3 0.4 0.7 -0.8 0.3
Had other major operations 0.3 0.4 0.8 -0.1 -0.9
Forced vital capacity (FVC) 1.7 6.5 10.6 -1.6 3.3
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 2.6 1.4 -1.6
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.6 -0.3 -0.8
Qualifications: None of the above 0.8 1.7 1.9 -1.4 1.2
Financial difficulties in last 2 years 2.5 3.4 5.5 -2.3 1.2
Mouth/teeth dental problems 0.6 0.9 1.0 0.9 1.0
Heart attack 0.2 0.2 0.3 -0.5 -0.4
Allergy 0.7 1.7 2.0 -1.1 1.4
Pain all over the body in last month 0.1 0.1 0.1 -0.3 0.1
Diabetes (self-reported) 0.2 0.3 0.5 -0.7 0.4
Hayfever/allergic rhinitis (self-reported) 1.7 2.2 3.0 -1.7 1.2
Medication: Ramipril 0.2 0.3 0.4 -0.7 0.3
Medication: Simvastatin 0.8 1.1 1.6 -0.8 1.3
Fluid intelligence score 0.5 1.0 1.7 0.5 1.3
Illnesses of siblings 0.0 0.1 0.1 -0.2 -0.3
Neuroticism score 0.3 0.6 0.9 -0.6 -0.9
Weight 1.7 8.4 10.2 -3.2 2.6
Impedance of arm (right) 1.5 7.0 8.8 -3.0 2.3
Arm fat percentage (right) 0.1 0.3 0.3 -0.5 0.5
Trunk fat-free mass 1.5 8.7 10.8 -3.3 2.5
Hip circumference 0.2 1.0 1.2 -1.1 0.9
Time employed in main current job 2.4 2.7 3.2 1.8 -1.5
Alcohol intake versus 10 years previously 5.9 8.8 10.2 -2.7 3.2
Father’s age at death 0.8 1.1 1.6 0.7 -1.3
Worrier / anxious feelings 0.0 0.0 0.1 0.1 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 0.8 -0.9 0.6
Falls in the last year 1.4 1.9 3.3 -0.7 1.8
Hair/balding pattern: Pattern 3 3.7 5.5 6.6 2.6 -2.1
Number of live births 0.1 0.2 0.3 -0.6 -0.2
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.1 -0.1 0.3
Pulse rate 0.8 1.3 1.5 -1.2 1.1
Happiness 3.6 4.3 5.5 -2.3 1.8
Noisy workplace 0.2 0.2 0.4 -0.6 0.1
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.3 -0.3 0.5
Serious illness, injury or assault of a close relative in last 2 years 2.4 2.7 4.4 -1.0 2.1
Mouth/teeth dental problems: Dentures 0.1 0.2 0.4 -0.6 -0.0
Asthma 1.0 1.9 3.6 1.9 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.3 -0.2 0.5
Medication: Cholesterol lowering 0.3 0.4 0.5 0.5 -0.7
Depression (self-reported) 0.5 0.6 0.8 -0.7 0.9
Medication: Lansoprazole 0.3 0.3 0.6 -0.8 0.1
Prospective memory result 0.3 0.3 0.5 -0.7 -0.4
Lung cancer (father) 0.3 0.3 0.6 0.2 -0.8
Illnesses of mother 0.6 0.7 1.2 0.4 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.1 0.4 0.2
Pulse wave Arterial Stiffness index 0.8 0.9 1.1 -0.9 1.0
Impedance of arm (left) 1.3 6.1 7.1 -2.7 2.2
Arm fat mass (right) 0.7 2.7 3.1 -1.8 1.5
Trunk predicted mass 1.5 8.7 10.8 -3.3 2.6
Standing height 6.7 66.2 80.5 -9.0 7.2
Length of working week for main job 0.2 0.3 0.4 -0.6 0.4
Exposure to tobacco smoke at home 0.3 0.3 0.5 -0.7 -0.3
Breastfed as a baby 3.4 4.3 6.9 2.6 -1.3
Tense / ‘highly strung’ 0.0 0.0 0.0 0.0 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.2 -0.0 0.4
Hair/balding pattern: Pattern 4 13.7 33.2 37.2 -5.4 6.1
Birth weight of first child 0.9 1.6 2.0 1.4 -1.0
Peak expiratory flow (PEF) 0.6 1.4 1.4 1.1 -1.2
Pulse wave reflection index 0.1 0.2 0.3 0.5 -0.3
Ever highly irritable/argumentative for 2 days 6.3 7.6 9.4 -3.1 2.4
Loud music exposure frequency 0.1 0.1 0.1 0.4 0.3
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.2 0.5 -0.5
Mouth/teeth dental problems: Bleeding gums 1.9 2.5 5.0 -2.2 -0.0
Blood clot in the leg (DVT) 0.3 0.3 0.7 -0.8 -0.1
Medication: Paracetamol 3.7 6.2 8.0 -2.8 2.1
Headache pain in last month 0.2 0.4 0.8 -0.9 0.3
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.4 -0.6 0.2
Glaucoma (self-reported) 1.1 1.3 2.3 -0.6 1.5
Gout (self-reported) 0.9 1.3 2.1 0.7 -1.4
Hypothyroidism/myxoedema (self-reported) 8.2 15.9 17.5 3.8 -4.2
Medication: Amlodipine 3.7 5.2 6.1 2.5 -2.0
Medication: Ventolin 100micrograms inhaler 1.9 2.4 4.1 2.0 -0.9
Birth weight 1.5 3.2 4.2 -1.5 2.1
Chronic bronchitis/emphysema (mother) 1.7 2.0 2.4 1.3 -1.5
High blood pressure (siblings) 0.7 0.9 1.9 1.4 -0.1
Forced vital capacity (FVC), Best measure 0.9 3.5 6.3 -0.8 2.5
Body fat percentage 1.6 6.4 8.4 -2.9 2.1
Leg fat percentage (right) 1.4 5.0 6.5 -2.6 1.9
Arm fat-free mass (right) 1.4 7.0 9.3 -3.0 2.2
Exposure to tobacco smoke outside home 0.7 0.9 1.8 -1.3 -0.1
Comparative body size at age 10 1.7 4.6 8.1 -2.9 1.0
Number of full brothers 0.3 0.4 0.8 0.1 0.9
Worry too long after embarrassment 0.1 0.1 0.1 -0.3 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.0 -0.8 1.0
Wheeze or whistling in the chest in last year 0.1 0.1 0.2 -0.4 0.2
Number of children fathered 0.0 0.0 0.0 0.1 0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.3 0.5 -0.0
Age at first live birth 1.5 2.7 5.5 2.3 -0.0
Pulse wave peak to peak time 0.0 0.0 0.0 0.0 -0.2
Health satisfaction 0.9 1.2 1.5 -1.0 1.2
Shortness of breath walking on level ground 0.8 0.9 1.5 -0.5 1.2
Qualifications: College or University degree 1.0 3.0 4.9 -1.0 2.2
Eye problems/disorders: None of the above 0.1 0.1 0.1 -0.3 0.2
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.3 -0.5 -0.5
Emphysema/chronic bronchitis 1.0 1.1 1.7 -0.7 1.3
Medication for pain relief, constipation, heartburn 1.9 3.3 5.6 2.4 -1.0
Neck or shoulder pain in last month 0.1 0.1 0.1 -0.1 -0.4
Medication: Blood pressure 0.3 0.5 0.9 1.0 0.4
Angina (self-reported) 0.0 0.0 0.0 -0.1 -0.0
Migraine (self-reported) 0.3 0.4 0.5 0.7 -0.5
Medication: Ibuprofen 0.1 0.1 0.2 0.2 -0.4
Medication: Allopurinol 0.1 0.1 0.2 -0.1 -0.4
Medication: Omeprazole 3.7 4.4 7.5 -2.7 1.1
Medication: Seretide 50 evohaler 2.5 2.9 4.8 -0.9 2.2
Mean time to correctly identify matches 0.1 0.1 0.1 0.3 -0.3
Heart disease (mother) 0.1 0.2 0.3 -0.3 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.5 2.5 0.6 -1.6
Whole body fat mass 2.2 9.2 11.7 -3.4 2.6
Leg fat mass (right) 2.0 7.7 9.5 -3.1 2.4
Arm predicted mass (right) 1.3 6.9 9.4 -3.1 2.1
Pulse rate, automated reading 0.1 0.4 0.8 -0.2 0.9
Alcohol intake frequency. 0.5 1.1 1.3 0.9 -1.2
Comparative height size at age 10 7.5 41.2 49.6 -7.0 5.7
Number of full sisters 1.0 1.3 2.3 -0.5 1.5
Suffer from ‘nerves’ 2.0 3.1 3.1 1.7 -1.8
Overall health rating 1.1 2.4 2.7 -1.5 1.6
Chest pain or discomfort 0.6 0.9 1.5 0.4 1.2
Had major operations 1.6 1.9 2.9 -0.9 1.7
Age at last live birth 0.5 0.8 1.5 0.1 1.2
Family relationship satisfaction 5.0 6.1 8.3 -2.9 2.0
Leg pain on walking 1.8 2.2 3.1 -1.8 1.2
Qualifications: NVQ or HND or HNC or equivalent 2.9 3.5 4.4 -2.1 1.6
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.7 0.8 0.2
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 2.6 1.6 -0.6
Medication: Aspirin 0.9 1.2 2.2 -1.5 0.5
Supplements: Vitamin C 0.9 1.1 1.8 0.7 -1.3
Knee pain experienced in last month 1.3 2.0 4.0 -2.0 0.1
Hypertension (Self-reported) 0.2 0.5 0.7 0.4 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 0.9 -0.9 0.7
Illnesses of father: Heart disease 0.5 0.7 1.0 -1.0 0.6
Illnesses of siblings: Diabetes 0.3 0.4 0.6 0.7 -0.4
Smoking status: Previous 5.1 7.6 8.4 2.6 -2.9
Forced expiratory volume in 1-second (FEV1), predicted 1.7 3.5 5.8 -2.4 1.1
Whole body fat-free mass 1.0 6.0 7.5 -2.7 2.1
Leg fat-free mass (right) 0.3 1.4 1.8 -1.3 1.0
Arm fat percentage (left) 0.2 0.6 0.7 -0.8 0.8
Average weekly red wine intake 1.0 1.5 3.0 -1.7 -0.2
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 -0.2 0.5
Mood swings 0.5 0.8 0.9 -0.9 -0.9
Loneliness, isolation 1.6 2.2 4.3 -2.1 -0.1
Long-standing illness, disability or infirmity 0.1 0.1 0.1 -0.3 0.2
Ever had bowel cancer screening 0.1 0.1 0.2 -0.4 0.3
Diabetes diagnosed by doctor 0.4 0.7 1.1 -1.1 0.5
Ever had stillbirth, spontaneous miscarriage or termination 2.2 2.4 2.8 -1.7 1.4
Friendships satisfaction 1.4 1.7 3.1 -1.8 0.6
Qualifications: nursing, teaching 1.4 2.2 3.2 1.1 -1.8
Commuting to job workplace: Walk 0.1 0.1 0.2 -0.1 -0.4
Eye problems/disorders: Cataract 0.6 0.7 0.7 0.8 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 0.8 0.9 -0.5
Medication for cholesterol 1.0 1.5 2.2 0.8 -1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.3 2.9 -1.7 1.3
Back pain experienced in last month 0.7 1.0 1.5 -1.2 0.7
Mineral and other dietary supplements 0.9 1.2 2.1 1.5 -0.5
Breast cancer (self-reported) 0.9 1.1 1.2 1.1 -1.0
Asthma (self-reported) 0.6 1.1 2.2 1.5 -0.2
Osteoporosis (self-reported) 0.2 0.2 0.4 -0.6 0.3
Osteoarthritis (self-reported) 1.0 1.2 1.6 1.0 -1.2
Medication: Aspirin 1.2 1.6 3.1 -1.8 0.3
Medication: Gliclazide 1.0 1.1 2.2 0.2 -1.5
Illnesses of father: None of the above (group 1) 0.2 0.3 0.6 0.8 -0.0
Smoking status: Current 5.1 8.2 11.8 -3.4 2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.5 3.1 5.2 2.3 -1.0
Whole body water mass 0.9 5.1 6.5 -2.5 1.9
Leg predicted mass (right) 0.3 1.5 1.9 -1.4 1.1
Arm fat mass (left) 0.8 3.1 3.5 -1.9 1.6
Number of self-reported non-cancer illnesses 0.1 0.2 0.4 0.0 0.6
Average weekly champagne plus white wine intake 0.4 0.5 1.0 -0.2 -1.0
Miserableness 0.3 0.5 1.0 -1.0 -0.2
Guilty feelings 1.4 2.2 3.9 -2.0 0.7
Wears glasses or contact lenses 0.1 0.1 0.1 0.1 0.3
Ever taken oral contraceptive pill 0.4 0.5 0.5 0.7 -0.7
Hearing aid user 0.2 0.2 0.2 -0.4 0.5
Mother’s age at death 0.2 0.2 0.3 -0.5 0.4
Financial situation satisfaction 3.1 3.8 5.1 -2.3 1.6
Tinnitus: Yes, now most or all of the time 2.1 2.5 4.0 2.0 -1.0
Commuting to job workplace: Public transport 0.2 0.3 0.6 0.2 0.7
Eye problems/disorders: Glaucoma 0.5 0.6 1.1 -0.1 1.1
Medication: Blood pressure 0.1 0.2 0.3 -0.2 0.6
Pain type(s) experienced in last month: Hip pain 0.9 1.2 2.2 0.3 -1.5
Supplements: Fish oil (including cod liver oil) 0.8 1.1 1.5 -0.8 -1.2
High cholesterol (Self-reported) 0.0 0.0 0.0 0.1 -0.1
Medication: Bendroflumethiazide 1.3 2.0 3.0 -1.0 1.7
Medication: Paracetamol 1.7 2.7 4.6 -2.1 0.9
Medication: Lisinopril 2.4 3.0 4.5 -1.3 2.1
Medication: Atorvastatin 0.7 0.9 1.2 -1.1 0.8
Illnesses of father: High blood pressure 1.6 1.9 2.5 1.2 -1.6
Alcohol drinker status: Never 0.4 0.5 0.7 -0.5 -0.8
Ever smoked 0.5 0.9 1.7 0.4 -1.3
Basal metabolic rate 1.3 7.2 8.7 -3.0 2.4
Leg fat percentage (left) 1.1 4.1 5.8 -2.4 1.6
Arm fat-free mass (left) 1.4 7.2 9.1 -3.0 2.3
Number of operations (self-reported) 0.7 1.1 1.9 1.4 -0.6
Average weekly beer plus cider intake 0.9 1.3 1.6 -1.0 1.3
Irritability 0.5 0.9 1.7 0.2 -1.3
Risk taking 2.7 3.9 6.0 -2.5 1.3
Ever had prostate specific antigen (PSA) test 1.3 1.5 1.7 1.2 -1.3
Fractured/broken bones in last 5 years 1.5 2.0 2.7 -1.6 1.1
Age started oral contraceptive pill 1.0 1.3 1.6 1.0 -1.3
Diastolic blood pressure, automated reading 0.1 0.4 0.4 0.6 -0.6
Ever depressed for a whole week 0.7 0.9 1.4 -1.2 0.6
Unable to work because of sickness or disability 0.0 0.1 0.1 -0.3 0.0
Commuting to job workplace: Cycle 0.0 0.0 0.1 -0.2 -0.1
Myopia 7.0 10.2 13.8 2.6 -3.7
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.6 0.2 -1.3
Cholesterol lowering medication 1.2 1.8 2.2 -1.1 1.5
Medication: Omeprazole (e.g. Zanprol) 3.0 3.6 6.2 -2.5 1.0
Pain experienced in last month 1.8 2.9 5.6 2.4 -0.6
Supplements: Calcium 0.2 0.3 0.5 0.7 0.0
Basal cell carcinoma (self-reported) 0.2 0.2 0.3 0.6 0.1
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.8 -0.9 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.8 -0.9 -0.2
Heart disease (siblings) 0.4 0.5 1.0 -1.0 0.0
Alcohol drinker status: Previous 0.2 0.2 0.4 0.6 0.1
Pack years of smoking 2.9 4.2 4.4 -2.0 2.1
Impedance of whole body 3.0 15.2 19.3 -4.4 3.3
Leg fat mass (left) 1.7 6.7 8.6 -2.9 2.2
Arm predicted mass (left) 1.5 7.5 9.6 -3.1 2.3