TWAS hub - RLTPR

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0376	0.0245	0.0032	0.000	0.001	0.001	0.003	0.00	0.3200	0.2100	0.260	0.11	0.3000
2	TCGA	Lung Adenocarcinoma	0.0254	0.0154	0.0084	0.022	0.017	0.011	NA	0.02	0.0012	0.0039	0.017	NA	0.0018

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hair/balding pattern: Pattern 4	13.7	33.2	37.2	-5.4	6.1
Hypothyroidism (self reported)	10.0	23.0	23.1	4.8	-4.8
Hypothyroidism/myxoedema (self-reported)	8.2	15.9	17.5	3.8	-4.2
Lung FEV1/FVC ratio	7.9	40.1	66.9	3.6	-8.2
Comparative height size at age 10	7.5	41.2	49.6	-7.0	5.7
Waist Hip Ratio (WHR)	7.1	32.1	35.9	-6.0	5.3
Myopia	7.0	10.2	13.8	2.6	-3.7
Medication: Levothyroxine sodium	6.8	11.6	12.7	3.2	-3.6
Standing height	6.7	66.2	80.5	-9.0	7.2
Ever highly irritable/argumentative for 2 days	6.3	7.6	9.4	-3.1	2.4
Current tobacco smoking	6.0	9.8	14.0	-3.7	2.4
Alcohol intake versus 10 years previously	5.9	8.8	10.2	-2.7	3.2
Qualifications: CSEs or equivalent	5.7	7.6	9.3	2.4	-3.0
Smoking status: Previous	5.1	7.6	8.4	2.6	-2.9
Smoking status: Current	5.1	8.2	11.8	-3.4	2.1
Family relationship satisfaction	5.0	6.1	8.3	-2.9	2.0
Bipolar Disorder or Schizophrenia	4.8	11.8	14.4	3.0	-3.8
Height	4.8	92.8	118.8	-10.9	8.2
Impedance of leg (right)	4.8	23.3	28.7	-5.4	4.2
Impedance of leg (left)	4.5	21.8	28.6	-5.3	3.9
Alcohol usually taken with meals	4.0	6.5	8.1	2.2	-2.9
Blood Red Count	3.9	38.0	46.1	5.5	-6.8
Hair/balding pattern: Pattern 3	3.7	5.5	6.6	2.6	-2.1
Medication: Paracetamol	3.7	6.2	8.0	-2.8	2.1
Medication: Amlodipine	3.7	5.2	6.1	2.5	-2.0
Medication: Omeprazole	3.7	4.4	7.5	-2.7	1.1
Happiness	3.6	4.3	5.5	-2.3	1.8
Bipolar Disorder (2018)	3.5	5.5	6.5	2.6	-2.1
Breastfed as a baby	3.4	4.3	6.9	2.6	-1.3
Fasting Glucose	3.3	4.0	7.5	-0.7	2.7
Chronotype (morning person)	3.3	7.7	8.4	-2.6	2.9
Serious illness, injury or assault to yourself	3.3	4.0	4.0	-2.0	2.0
Schizophrenia (2018)	3.2	6.6	10.0	1.8	-3.2
Blood Eosinophil Count	3.1	24.0	41.1	-6.4	2.6
Financial situation satisfaction	3.1	3.8	5.1	-2.3	1.6
Heel T-Score	3.0	24.0	28.1	4.5	-5.3
Medication: Omeprazole (e.g. Zanprol)	3.0	3.6	6.2	-2.5	1.0
Impedance of whole body	3.0	15.2	19.3	-4.4	3.3
Trunk fat mass	2.9	12.6	15.7	-4.0	3.1
Qualifications: NVQ or HND or HNC or equivalent	2.9	3.5	4.4	-2.1	1.6
Pack years of smoking	2.9	4.2	4.4	-2.0	2.1
Waist circumference	2.8	10.3	11.1	-3.3	3.1
Risk taking	2.7	3.9	6.0	-2.5	1.3
Ovarian Cancer	2.6	3.4	4.4	-1.6	2.1
Pack years adult smoking proportion	2.6	3.9	4.0	-2.0	2.0
Financial difficulties in last 2 years	2.5	3.4	5.5	-2.3	1.2
Medication: Seretide 50 evohaler	2.5	2.9	4.8	-0.9	2.2
Time employed in main current job	2.4	2.7	3.2	1.8	-1.5
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.7	4.4	-1.0	2.1
Medication: Lisinopril	2.4	3.0	4.5	-1.3	2.1
Diabetes (mother)	2.3	2.9	4.6	-2.1	1.1
Hearing difficulty/problems: Yes	2.2	3.3	6.4	2.5	-0.5
Nervous feelings	2.2	4.1	5.0	2.2	-1.8
Whole body fat mass	2.2	9.2	11.7	-3.4	2.6
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.4	2.8	-1.7	1.4
Mean Putamen Volume	2.1	2.4	3.5	1.9	-1.1
Blood White Count	2.1	15.5	20.0	-3.3	4.5
Tinnitus: Yes, now most or all of the time	2.1	2.5	4.0	2.0	-1.0
Trunk fat percentage	2.0	8.1	10.4	-3.2	2.4
Leg fat mass (right)	2.0	7.7	9.5	-3.1	2.4
Suffer from ‘nerves’	2.0	3.1	3.1	1.7	-1.8
Alzheimer’s Disease (in father)	1.9	2.1	2.3	1.5	-1.4
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	5.0	-2.2	-0.0
Medication: Ventolin 100micrograms inhaler	1.9	2.4	4.1	2.0	-0.9
Medication for pain relief, constipation, heartburn	1.9	3.3	5.6	2.4	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.3	2.9	-1.7	1.3
Supplements: Glucosamine	1.8	2.4	3.0	-1.3	1.7
Leg pain on walking	1.8	2.2	3.1	-1.8	1.2
Pain experienced in last month	1.8	2.9	5.6	2.4	-0.6
Major Depression (MDD)	1.7	2.0	3.8	1.9	-0.5
Schizophrenia (2014)	1.7	3.8	6.5	1.0	-2.6
Forced vital capacity (FVC)	1.7	6.5	10.6	-1.6	3.3
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	3.0	-1.7	1.2
Weight	1.7	8.4	10.2	-3.2	2.6
Chronic bronchitis/emphysema (mother)	1.7	2.0	2.4	1.3	-1.5
Comparative body size at age 10	1.7	4.6	8.1	-2.9	1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	5.8	-2.4	1.1
Medication: Paracetamol	1.7	2.7	4.6	-2.1	0.9
Leg fat mass (left)	1.7	6.7	8.6	-2.9	2.2
Ever had hysterectomy (womb removed)	1.6	1.8	3.1	-1.8	0.7
Body fat percentage	1.6	6.4	8.4	-2.9	2.1
Had major operations	1.6	1.9	2.9	-0.9	1.7
Loneliness, isolation	1.6	2.2	4.3	-2.1	-0.1
Illnesses of father: High blood pressure	1.6	1.9	2.5	1.2	-1.6
Type 2 Diabetes (T2D) (2012)	1.5	1.7	3.4	1.9	0.0
Maternal smoking around birth	1.5	2.2	3.4	-1.8	1.0
Number of incorrect matches in round	1.5	2.5	4.8	-2.2	0.4
Impedance of arm (right)	1.5	7.0	8.8	-3.0	2.3
Trunk fat-free mass	1.5	8.7	10.8	-3.3	2.5
Trunk predicted mass	1.5	8.7	10.8	-3.3	2.6
Birth weight	1.5	3.2	4.2	-1.5	2.1
Age at first live birth	1.5	2.7	5.5	2.3	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.1	5.2	2.3	-1.0
Fractured/broken bones in last 5 years	1.5	2.0	2.7	-1.6	1.1
Arm predicted mass (left)	1.5	7.5	9.6	-3.1	2.3
Falls in the last year	1.4	1.9	3.3	-0.7	1.8
Leg fat percentage (right)	1.4	5.0	6.5	-2.6	1.9
Arm fat-free mass (right)	1.4	7.0	9.3	-3.0	2.2
Friendships satisfaction	1.4	1.7	3.1	-1.8	0.6
Qualifications: nursing, teaching	1.4	2.2	3.2	1.1	-1.8
Guilty feelings	1.4	2.2	3.9	-2.0	0.7
Arm fat-free mass (left)	1.4	7.2	9.1	-3.0	2.3
Primary Biliary Cirrhosis	1.3	1.8	3.1	-1.8	0.7
Blood Platelet Count	1.3	14.9	15.1	-3.9	3.9
Average weekly spirits intake	1.3	1.6	2.4	-1.5	0.9
Impedance of arm (left)	1.3	6.1	7.1	-2.7	2.2
Arm predicted mass (right)	1.3	6.9	9.4	-3.1	2.1
Knee pain experienced in last month	1.3	2.0	4.0	-2.0	0.1
Medication: Bendroflumethiazide	1.3	2.0	3.0	-1.0	1.7
Basal metabolic rate	1.3	7.2	8.7	-3.0	2.4
Ever had prostate specific antigen (PSA) test	1.3	1.5	1.7	1.2	-1.3
Body Mass Index (BMI) (2010)	1.2	1.6	3.2	1.8	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	2.5	0.6	-1.6
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.6	1.6	-0.6
Medication: Aspirin	1.2	1.6	3.1	-1.8	0.3
Cholesterol lowering medication	1.2	1.8	2.2	-1.1	1.5
Prostate Cancer	1.1	1.6	2.7	-0.7	1.7
HDL Cholesterol	1.1	1.8	3.6	-1.9	0.0
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	2.2	0.3	-1.5
Hearing difficulty/problems with background noise	1.1	1.7	3.5	1.9	0.2
Glaucoma (self-reported)	1.1	1.3	2.3	-0.6	1.5
Overall health rating	1.1	2.4	2.7	-1.5	1.6
Leg fat percentage (left)	1.1	4.1	5.8	-2.4	1.6
Past tobacco smoking	1.0	1.8	2.5	-1.0	1.6
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	2.6	1.4	-1.6
Asthma	1.0	1.9	3.6	1.9	-0.4
Qualifications: College or University degree	1.0	3.0	4.9	-1.0	2.2
Emphysema/chronic bronchitis	1.0	1.1	1.7	-0.7	1.3
Number of full sisters	1.0	1.3	2.3	-0.5	1.5
Whole body fat-free mass	1.0	6.0	7.5	-2.7	2.1
Average weekly red wine intake	1.0	1.5	3.0	-1.7	-0.2
Medication for cholesterol	1.0	1.5	2.2	0.8	-1.5
Osteoarthritis (self-reported)	1.0	1.2	1.6	1.0	-1.2
Medication: Gliclazide	1.0	1.1	2.2	0.2	-1.5
Age started oral contraceptive pill	1.0	1.3	1.6	1.0	-1.3
Alzheimer’s Disease (in mother)	0.9	1.1	2.0	-0.4	1.4
Sensitivity / hurt feelings	0.9	1.6	2.1	-1.4	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.9	1.9	2.4	1.2	-1.5
Birth weight of first child	0.9	1.6	2.0	1.4	-1.0
Gout (self-reported)	0.9	1.3	2.1	0.7	-1.4
Forced vital capacity (FVC), Best measure	0.9	3.5	6.3	-0.8	2.5
Health satisfaction	0.9	1.2	1.5	-1.0	1.2
Medication: Aspirin	0.9	1.2	2.2	-1.5	0.5
Supplements: Vitamin C	0.9	1.1	1.8	0.7	-1.3
Mineral and other dietary supplements	0.9	1.2	2.1	1.5	-0.5
Breast cancer (self-reported)	0.9	1.1	1.2	1.1	-1.0
Whole body water mass	0.9	5.1	6.5	-2.5	1.9
Pain type(s) experienced in last month: Hip pain	0.9	1.2	2.2	0.3	-1.5
Average weekly beer plus cider intake	0.9	1.3	1.6	-1.0	1.3
Depressed Affect (Nagel 2018)	0.8	1.6	3.1	-1.8	-0.3
Depression (Nagel 2018)	0.8	1.3	2.5	-1.6	0.1
Age at First Birth	0.8	1.2	1.9	1.4	-0.7
Sitting height	0.8	5.5	7.2	-2.7	2.0
Qualifications: None of the above	0.8	1.7	1.9	-1.4	1.2
Medication: Simvastatin	0.8	1.1	1.6	-0.8	1.3
Father’s age at death	0.8	1.1	1.6	0.7	-1.3
Pulse rate	0.8	1.3	1.5	-1.2	1.1
Pulse wave Arterial Stiffness index	0.8	0.9	1.1	-0.9	1.0
Shortness of breath walking on level ground	0.8	0.9	1.5	-0.5	1.2
Arm fat mass (left)	0.8	3.1	3.5	-1.9	1.6
Supplements: Fish oil (including cod liver oil)	0.8	1.1	1.5	-0.8	-1.2
Schizophrenia vs Biploar Disorder	0.7	0.9	1.8	-1.4	-0.2
Lung FVC	0.7	3.5	6.2	2.5	0.9
Hayfever, allergic rhinitis or eczema	0.7	1.5	2.0	1.0	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	1.5	-1.2	-0.7
Allergy	0.7	1.7	2.0	-1.1	1.4
Arm fat mass (right)	0.7	2.7	3.1	-1.8	1.5
High blood pressure (siblings)	0.7	0.9	1.9	1.4	-0.1
Exposure to tobacco smoke outside home	0.7	0.9	1.8	-1.3	-0.1
Back pain experienced in last month	0.7	1.0	1.5	-1.2	0.7
Medication: Atorvastatin	0.7	0.9	1.2	-1.1	0.8
Number of operations (self-reported)	0.7	1.1	1.9	1.4	-0.6
Ever depressed for a whole week	0.7	0.9	1.4	-1.2	0.6
Coronary Artery Disease (CAD)	0.6	0.7	1.5	-1.2	0.0
Cardiovascular Disease	0.6	1.9	2.5	-1.1	1.6
Severe depression (siblings)	0.6	0.7	1.3	-1.2	-0.1
High blood pressure (mother)	0.6	0.8	1.5	1.2	-0.4
Mouth/teeth dental problems	0.6	0.9	1.0	0.9	1.0
Illnesses of mother	0.6	0.7	1.2	0.4	-1.1
Peak expiratory flow (PEF)	0.6	1.4	1.4	1.1	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.0	-0.8	1.0
Chest pain or discomfort	0.6	0.9	1.5	0.4	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	0.9	-0.9	0.7
Eye problems/disorders: Cataract	0.6	0.7	0.7	0.8	-0.8
Asthma (self-reported)	0.6	1.1	2.2	1.5	-0.2
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.3	1.5	0.3
Crohns Disease (2012)	0.5	0.8	1.5	-0.2	1.2
Number of treatments/medications taken	0.5	0.8	0.9	-0.9	0.9
Supplements: Zinc	0.5	0.5	1.1	-0.0	-1.0
Leg fat-free mass (left)	0.5	2.4	2.8	-1.7	1.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	0.7	0.8	-0.7
Leg predicted mass (left)	0.5	2.7	3.1	-1.8	1.5
Fluid intelligence score	0.5	1.0	1.7	0.5	1.3
Depression (self-reported)	0.5	0.6	0.8	-0.7	0.9
Alcohol intake frequency.	0.5	1.1	1.3	0.9	-1.2
Age at last live birth	0.5	0.8	1.5	0.1	1.2
Illnesses of father: Heart disease	0.5	0.7	1.0	-1.0	0.6
Mood swings	0.5	0.8	0.9	-0.9	-0.9
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	-0.1	1.1
Ever smoked	0.5	0.9	1.7	0.4	-1.3
Irritability	0.5	0.9	1.7	0.2	-1.3
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.0	1.4	0.4
Type 2 Diabetes (T2D) (2018)	0.4	0.8	0.9	-0.8	0.9
Hair Pigment	0.4	10.1	11.8	2.9	-3.4
Relative age voice broke	0.4	0.6	1.1	1.1	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	0.8	-0.9	0.6
Diabetes diagnosed by doctor	0.4	0.7	1.1	-1.1	0.5
Average weekly champagne plus white wine intake	0.4	0.5	1.0	-0.2	-1.0
Ever taken oral contraceptive pill	0.4	0.5	0.5	0.7	-0.7
Alcohol drinker status: Never	0.4	0.5	0.7	-0.5	-0.8
Heart disease (siblings)	0.4	0.5	1.0	-1.0	0.0
Worry (Nagel 2018)	0.3	0.6	0.8	0.6	-0.9
Crohns Disease (2017)	0.3	0.6	1.2	-0.0	1.1
Breast Cancer	0.3	0.7	1.4	-0.2	1.2
LDL Cholesterol	0.3	0.5	1.0	1.0	0.0
BMI	0.3	1.7	1.9	1.4	-1.2
Smoking Status	0.3	0.8	1.6	-1.3	-0.2
Respiratory disease	0.3	0.7	1.4	1.2	-0.1
Neuroticism	0.3	0.7	0.9	-0.7	-0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	-0.5	0.8
Medication for hormone replacement therapy	0.3	0.3	0.4	-0.4	0.7
Vitamin and mineral supplements	0.3	0.5	0.8	0.4	0.9
Medication: Co-codamol	0.3	0.4	0.6	0.5	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.7	-0.8	-0.3
High blood pressure	0.3	0.7	1.4	0.2	1.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.7	-0.1	-0.8
Medication: Atenolol	0.3	0.4	0.6	-0.6	0.7
Had menopause	0.3	0.4	0.7	-0.8	0.3
Had other major operations	0.3	0.4	0.8	-0.1	-0.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.6	-0.3	-0.8
Neuroticism score	0.3	0.6	0.9	-0.6	-0.9
Medication: Cholesterol lowering	0.3	0.4	0.5	0.5	-0.7
Medication: Lansoprazole	0.3	0.3	0.6	-0.8	0.1
Prospective memory result	0.3	0.3	0.5	-0.7	-0.4
Lung cancer (father)	0.3	0.3	0.6	0.2	-0.8
Exposure to tobacco smoke at home	0.3	0.3	0.5	-0.7	-0.3
Blood clot in the leg (DVT)	0.3	0.3	0.7	-0.8	-0.1
Number of full brothers	0.3	0.4	0.8	0.1	0.9
Medication: Blood pressure	0.3	0.5	0.9	1.0	0.4
Migraine (self-reported)	0.3	0.4	0.5	0.7	-0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.7	0.8	0.2
Illnesses of siblings: Diabetes	0.3	0.4	0.6	0.7	-0.4
Leg fat-free mass (right)	0.3	1.4	1.8	-1.3	1.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.8	0.9	-0.5
Leg predicted mass (right)	0.3	1.5	1.9	-1.4	1.1
Miserableness	0.3	0.5	1.0	-1.0	-0.2
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.6	0.2	-1.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	-0.9	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	-0.9	-0.2
Neuroticism (Nagel 2018)	0.2	0.5	0.8	-0.9	-0.5
Irritable Bowel Disease (IBD)	0.2	0.5	0.9	-0.3	0.9
HbA1C	0.2	0.2	0.4	0.6	0.1
Ulcerative Colitis	0.2	0.3	0.3	-0.6	0.6
Tanning	0.2	2.8	3.9	-2.0	1.3
Systolic blood pressure, automated reading	0.2	0.7	1.0	1.0	-0.7
Medication: Metformin	0.2	0.3	0.4	0.4	-0.6
Average weekly fortified wine intake	0.2	0.2	0.3	-0.2	-0.6
Fed-up feelings	0.2	0.4	0.5	-0.7	-0.6
Multivitamins +/- minerals	0.2	0.3	0.5	-0.2	-0.7
Heart attack	0.2	0.2	0.3	-0.5	-0.4
Diabetes (self-reported)	0.2	0.3	0.5	-0.7	0.4
Medication: Ramipril	0.2	0.3	0.4	-0.7	0.3
Hip circumference	0.2	1.0	1.2	-1.1	0.9
Noisy workplace	0.2	0.2	0.4	-0.6	0.1
Length of working week for main job	0.2	0.3	0.4	-0.6	0.4
Headache pain in last month	0.2	0.4	0.8	-0.9	0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.3	-0.5	-0.5
Hypertension (Self-reported)	0.2	0.5	0.7	0.4	0.9
Arm fat percentage (left)	0.2	0.6	0.7	-0.8	0.8
Osteoporosis (self-reported)	0.2	0.2	0.4	-0.6	0.3
Illnesses of father: None of the above (group 1)	0.2	0.3	0.6	0.8	-0.0
Hearing aid user	0.2	0.2	0.2	-0.4	0.5
Mother’s age at death	0.2	0.2	0.3	-0.5	0.4
Commuting to job workplace: Public transport	0.2	0.3	0.6	0.2	0.7
Supplements: Calcium	0.2	0.3	0.5	0.7	0.0
Basal cell carcinoma (self-reported)	0.2	0.2	0.3	0.6	0.1
Alcohol drinker status: Previous	0.2	0.2	0.4	0.6	0.1
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.3	0.5
Lupus	0.1	0.2	0.2	-0.4	-0.5
Neuroticism (2016)	0.1	0.2	0.4	-0.6	-0.1
Rheumatoid Arthritis	0.1	0.1	0.2	0.1	-0.5
Systolic Blood Pressure	0.1	0.3	0.6	0.3	-0.8
Allergy or Eczema	0.1	0.2	0.3	0.6	-0.4
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.1	-0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.4	0.2
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.2	-0.5
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.5	0.2
Stomach or abdominal pain in last month	0.1	0.2	0.3	-0.2	-0.6
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	-0.1	0.3
Body mass index (BMI)	0.1	0.5	0.6	0.8	-0.6
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	-0.3	0.2
Pain all over the body in last month	0.1	0.1	0.1	-0.3	0.1
Arm fat percentage (right)	0.1	0.3	0.3	-0.5	0.5
Number of live births	0.1	0.2	0.3	-0.6	-0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.3	-0.3	0.5
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	-0.6	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.3	-0.2	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.0	0.4
Pulse wave reflection index	0.1	0.2	0.3	0.5	-0.3
Loud music exposure frequency	0.1	0.1	0.1	0.4	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.2	0.5	-0.5
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	-0.6	0.2
Worry too long after embarrassment	0.1	0.1	0.1	-0.3	-0.4
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	-0.4	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	0.5	-0.0
Eye problems/disorders: None of the above	0.1	0.1	0.1	-0.3	0.2
Neck or shoulder pain in last month	0.1	0.1	0.1	-0.1	-0.4
Medication: Ibuprofen	0.1	0.1	0.2	0.2	-0.4
Medication: Allopurinol	0.1	0.1	0.2	-0.1	-0.4
Mean time to correctly identify matches	0.1	0.1	0.1	0.3	-0.3
Heart disease (mother)	0.1	0.2	0.3	-0.3	0.5
Pulse rate, automated reading	0.1	0.4	0.8	-0.2	0.9
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.2	0.5
Long-standing illness, disability or infirmity	0.1	0.1	0.1	-0.3	0.2
Ever had bowel cancer screening	0.1	0.1	0.2	-0.4	0.3
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.1	-0.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.0	0.6
Wears glasses or contact lenses	0.1	0.1	0.1	0.1	0.3
Medication: Blood pressure	0.1	0.2	0.3	-0.2	0.6
Diastolic blood pressure, automated reading	0.1	0.4	0.4	0.6	-0.6
Ulcerative Colitis (UC)	0.0	0.0	0.0	-0.2	0.1
Reaction Time	0.0	0.1	0.1	-0.3	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.1	0.3	0.0
Hand grip strength (left)	0.0	0.1	0.1	-0.2	0.3
Relative age of first facial hair	0.0	0.1	0.1	-0.1	0.4
Angina	0.0	0.1	0.1	-0.4	0.0
Diabetes (father)	0.0	0.1	0.1	-0.1	-0.3
Hand grip strength (right)	0.0	0.1	0.1	-0.3	0.0
Taking other prescription medications	0.0	0.0	0.0	-0.0	0.0
Age when periods started (menarche)	0.0	0.1	0.1	0.4	0.1
Illnesses of siblings	0.0	0.1	0.1	-0.2	-0.3
Worrier / anxious feelings	0.0	0.0	0.1	0.1	-0.3
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.1	-0.1	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.1	0.4	0.2
Tense / ‘highly strung’	0.0	0.0	0.0	0.0	0.1
Number of children fathered	0.0	0.0	0.0	0.1	0.0
Pulse wave peak to peak time	0.0	0.0	0.0	0.0	-0.2
Angina (self-reported)	0.0	0.0	0.0	-0.1	-0.0
High cholesterol (Self-reported)	0.0	0.0	0.0	0.1	-0.1
Unable to work because of sickness or disability	0.0	0.1	0.1	-0.3	0.0
Commuting to job workplace: Cycle	0.0	0.0	0.1	-0.2	-0.1

Hub : Genes

RLTPR

Models

Trait associations