Hub : Genes

CTCF

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Nucleus accumbens basal ganglia 0.1110 0.0560 0.0031 0.033 NA 0.000 NA 0.045 0.0450 NA 0.32 NA 0.0240
2 METSIM Adipose 0.0308 0.0187 0.0055 0.017 0.011 0.002 0.013 0.011 0.0011 0.0066 0.17 0.0034 0.0064

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 3.8 6.0 8.0 2.8 2.0
Bipolar Disorder or Schizophrenia 6.4 15.6 24.9 5.0 2.5
Depressed Affect (Nagel 2018) 0.7 1.4 2.5 1.6 -0.6
Depression (Nagel 2018) 0.3 0.5 0.7 0.6 -0.8
Intelligence (Savage-Jansen 2018) 1.3 4.1 8.2 -2.9 0.2
Neuroticism (Nagel 2018) 1.0 2.3 4.5 2.1 -0.2
Schizophrenia (2018) 4.7 9.9 16.9 4.1 1.7
Schizophrenia vs Biploar Disorder 1.8 2.4 2.8 1.7 -1.4
Worry (Nagel 2018) 1.1 2.4 4.3 2.1 0.7
Alzheimer’s Disease (in mother) 0.6 0.7 0.9 -0.7 -1.0
Alzheimer’s Disease (in father) 5.4 5.8 8.5 1.8 2.9
Alzheimer’s Disease (including proxy) 0.2 0.3 0.5 0.2 0.7
Crohns Disease (2017) 0.7 1.4 2.3 -1.5 -0.7
Irritable Bowel Disease (IBD) 0.2 0.6 0.7 -0.7 -0.8
Ulcerative Colitis (UC) 0.1 0.3 0.4 0.7 -0.3
Major Depression (MDD) 0.3 0.4 0.8 0.9 0.0
Reaction Time 0.9 1.8 2.8 -0.9 -1.7
Verbal and Numeric Reasoning (VNR) 0.7 1.6 3.1 -1.8 0.3
Breast Cancer 0.8 2.0 4.0 -2.0 0.2
Ovarian Cancer 4.8 6.4 12.7 -3.6 -0.2
Prostate Cancer 1.5 2.2 4.2 -2.1 -0.3
Age at First Birth 0.4 0.5 0.6 -0.6 0.8
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.4 1.9 2.1 1.3 1.5
Coronary Artery Disease (CAD) 1.0 1.2 1.5 -1.2 -0.9
Crohns Disease (2012) 1.0 1.6 2.3 -1.5 -0.9
Mean Putamen Volume 2.0 2.3 3.8 0.9 1.9
Fasting Glucose 4.9 5.9 10.7 -3.3 -1.0
HbA1C 0.1 0.1 0.2 -0.3 0.5
HDL Cholesterol 9.4 15.7 28.7 5.4 -1.6
LDL Cholesterol 0.3 0.5 0.9 0.3 0.9
Lupus 0.6 0.9 1.3 1.1 -0.7
Neuroticism (2016) 1.4 2.1 4.0 2.0 -0.4
Primary Biliary Cirrhosis 1.8 2.6 4.2 1.1 -2.0
Rheumatoid Arthritis 0.5 0.6 1.2 0.2 1.1
Schizophrenia (2014) 3.8 8.4 15.7 4.0 1.1
Triglycerides 0.3 0.5 0.6 -0.6 0.8
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.8 0.2 1.4
Ulcerative Colitis 0.0 0.0 0.0 -0.0 0.1
Blood Eosinophil Count 1.1 8.6 16.7 0.6 -4.1
Blood Platelet Count 0.7 8.0 9.8 -2.5 -3.1
Blood Red Count 6.0 57.7 90.2 9.5 5.0
Blood White Count 1.1 8.2 9.5 -2.6 -3.1
Heel T-Score 3.8 30.3 44.8 4.0 6.7
BMI 0.5 3.0 5.5 2.3 0.7
Height 3.6 68.9 85.7 -7.2 -9.3
Waist Hip Ratio (WHR) 7.2 32.2 33.4 -5.8 -5.6
Systolic Blood Pressure 0.0 0.0 0.0 0.1 0.0
Smoking Status 0.3 0.7 1.0 1.0 -0.6
Allergy or Eczema 0.5 1.3 2.4 -1.5 0.5
Cardiovascular Disease 0.4 1.2 2.4 -0.2 -1.5
Hypothyroidism (self reported) 13.7 31.4 39.8 6.3 4.8
Respiratory disease 0.5 1.2 1.4 -1.0 1.2
Type 2 Diabetes (T2D) (2018) 0.4 0.8 0.9 -1.0 -0.8
Lung FEV1/FVC ratio 14.3 72.6 128.2 11.3 4.1
Lung FVC 1.0 5.3 10.6 -3.3 -0.1
Neuroticism 1.0 2.5 5.0 2.2 0.0
Chronotype (morning person) 2.2 5.2 5.2 -2.3 -2.3
Hair Pigment 0.5 13.5 18.8 4.3 2.8
Tanning 0.0 0.3 0.5 0.4 -0.7
Hand grip strength (left) 0.0 0.1 0.2 0.2 0.5
Number of treatments/medications taken 0.5 0.8 1.0 1.0 -0.8
Average weekly spirits intake 2.8 3.4 6.0 -2.5 -0.9
Sensitivity / hurt feelings 0.5 0.9 1.8 -0.1 -1.3
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.1 1.1 0.6
Hearing difficulty/problems: Yes 1.4 2.1 4.2 -0.2 2.1
Relative age of first facial hair 0.1 0.3 0.6 -0.8 0.2
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.6 -0.2 -0.7
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.4 -0.6 -0.2
Ever had hysterectomy (womb removed) 1.0 1.1 2.2 0.2 -1.5
Systolic blood pressure, automated reading 0.0 0.0 0.0 0.1 0.2
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.3 -0.2 -0.5
Angina 0.0 0.1 0.1 0.0 0.3
Medication for hormone replacement therapy 0.4 0.5 0.5 -0.6 -0.7
Vitamin and mineral supplements 0.7 0.9 1.4 -1.2 -0.7
Supplements: Zinc 1.6 1.8 2.7 1.6 0.9
Medication: Co-codamol 1.1 1.2 2.2 1.5 0.6
Medication: Metformin 0.2 0.3 0.3 0.5 0.6
Diabetes (father) 0.4 0.5 0.5 0.7 -0.7
Diabetes (mother) 0.3 0.4 0.6 0.8 0.4
Severe depression (siblings) 0.4 0.5 0.6 0.8 -0.6
Pack years adult smoking proportion 1.8 2.8 3.5 -1.9 -1.4
Impedance of leg (right) 3.1 14.9 21.2 -2.9 -4.6
Leg fat-free mass (left) 0.4 2.2 2.9 -1.2 -1.7
Trunk fat percentage 0.9 3.7 7.4 0.0 -2.7
Hand grip strength (right) 0.1 0.2 0.2 0.4 0.4
Townsend deprivation index at recruitment 0.2 0.3 0.4 -0.3 0.7
Current tobacco smoking 2.7 4.4 7.4 -1.2 -2.7
Average weekly fortified wine intake 0.1 0.1 0.2 -0.3 -0.5
Maternal smoking around birth 1.2 1.7 1.9 -1.2 -1.4
Fed-up feelings 0.5 0.9 1.8 1.4 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.7 0.8 0.0
Relative age voice broke 0.2 0.3 0.5 0.4 0.7
Taking other prescription medications 0.4 0.6 1.1 1.1 -0.3
Age when periods started (menarche) 0.0 0.1 0.2 0.2 -0.4
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 2.7 1.6 0.7
Heel bone mineral density (BMD) T-score, automated (left) 1.9 4.3 8.1 0.7 2.8
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.3 0.3 0.5
Qualifications: CSEs or equivalent 6.5 8.6 9.1 2.9 3.0
Serious illness, injury or assault to yourself 4.7 5.7 7.5 -2.7 -2.0
High blood pressure 0.1 0.4 0.4 -0.7 -0.6
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.7 -0.0 0.8
Multivitamins +/- minerals 1.1 1.4 1.7 1.3 1.0
Stomach or abdominal pain in last month 1.4 1.8 3.2 1.8 0.6
Supplements: Glucosamine 1.8 2.3 3.9 -2.0 -0.8
Diverticular disease/diverticulitis (self-reported) 0.0 0.0 0.0 0.0 0.2
Medication: Atenolol 0.9 1.1 2.2 0.3 -1.5
Medication: Levothyroxine sodium 10.4 17.6 18.8 4.3 4.1
Sitting height 0.8 5.6 5.7 -2.4 -2.4
Chronic bronchitis/emphysema (father) 0.2 0.3 0.6 -0.8 0.1
High blood pressure (mother) 1.0 1.4 1.5 1.2 1.1
Body mass index (BMI) 0.2 1.1 1.8 1.4 0.5
Impedance of leg (left) 2.9 13.9 21.7 -2.5 -4.7
Leg predicted mass (left) 0.4 2.3 3.0 -1.2 -1.7
Trunk fat mass 1.5 6.4 12.0 -0.9 -3.5
Waist circumference 2.6 9.4 12.5 -2.5 -3.5
Number of incorrect matches in round 1.7 2.8 5.6 -0.4 -2.4
Past tobacco smoking 0.6 1.1 1.6 -1.3 -0.8
Alcohol usually taken with meals 4.5 7.3 10.5 3.2 2.0
Nervous feelings 2.0 3.7 3.8 1.9 1.9
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 2.5 1.6 0.1
Hearing difficulty/problems with background noise 0.1 0.1 0.2 -0.1 0.5
Hair/balding pattern: Pattern 2 0.0 0.0 0.1 0.3 0.0
Had menopause 0.3 0.4 0.9 -0.1 -0.9
Had other major operations 0.8 1.0 2.0 1.4 0.2
Forced vital capacity (FVC) 3.8 14.7 19.8 -4.5 -3.1
Heel bone mineral density (BMD) T-score, automated (right) 2.3 5.2 10.2 0.4 3.2
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 1.3 0.8 -1.1
Qualifications: None of the above 0.1 0.2 0.4 -0.6 -0.3
Financial difficulties in last 2 years 2.6 3.4 6.3 -0.7 -2.5
Mouth/teeth dental problems 0.3 0.4 0.6 -0.8 -0.5
Heart attack 0.6 0.8 1.4 1.2 0.5
Allergy 0.2 0.6 1.1 -0.2 -1.0
Pain all over the body in last month 0.1 0.1 0.3 0.5 0.1
Diabetes (self-reported) 0.3 0.5 0.7 -0.5 -0.9
Hayfever/allergic rhinitis (self-reported) 1.0 1.4 2.4 -1.5 -0.6
Medication: Ramipril 0.1 0.1 0.2 -0.1 -0.5
Medication: Simvastatin 0.2 0.3 0.5 0.4 -0.7
Fluid intelligence score 1.8 3.7 7.5 -2.7 -0.1
Illnesses of siblings 0.4 0.6 0.9 1.0 0.5
Neuroticism score 0.9 1.9 3.8 1.9 0.2
Weight 1.2 6.1 9.6 -1.6 -3.1
Impedance of arm (right) 0.8 3.9 6.9 -1.0 -2.6
Arm fat percentage (right) 0.2 0.8 1.2 1.1 -0.6
Trunk fat-free mass 1.6 9.3 11.1 -2.8 -3.3
Hip circumference 0.2 0.7 1.4 -0.2 -1.2
Time employed in main current job 3.1 3.6 5.4 1.3 2.3
Alcohol intake versus 10 years previously 4.6 6.9 7.3 -2.6 -2.7
Father’s age at death 1.0 1.3 2.4 1.6 0.5
Worrier / anxious feelings 0.1 0.3 0.5 0.7 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.0 0.1 -0.2 -0.0
Falls in the last year 3.7 5.0 9.3 -3.0 -0.8
Hair/balding pattern: Pattern 3 1.9 2.9 4.9 0.9 2.2
Number of live births 1.3 1.9 2.5 1.6 1.2
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.3 -0.5 -1.1
Pulse rate 0.9 1.5 1.5 -1.2 -1.2
Happiness 4.9 6.0 7.9 -2.0 -2.8
Noisy workplace 0.0 0.0 0.0 -0.1 -0.1
Qualifications: A levels/AS levels or equivalent 1.1 2.4 3.9 -2.0 -0.9
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.0 3.5 -1.9 -0.7
Mouth/teeth dental problems: Dentures 0.2 0.4 0.7 -0.2 0.8
Asthma 1.0 2.0 3.0 -1.0 1.7
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.0 0.0 0.1 0.1
Medication: Cholesterol lowering 1.0 1.5 2.3 1.5 0.9
Depression (self-reported) 0.0 0.0 0.0 0.2 -0.1
Medication: Lansoprazole 0.6 0.6 1.1 0.4 -1.1
Prospective memory result 1.3 1.6 3.2 1.8 -0.2
Lung cancer (father) 0.5 0.6 1.1 1.1 -0.3
Illnesses of mother 0.0 0.1 0.1 -0.2 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.4 -0.4 -0.6
Pulse wave Arterial Stiffness index 1.4 1.6 1.9 1.1 -1.4
Impedance of arm (left) 0.6 2.9 4.9 -1.0 -2.2
Arm fat mass (right) 0.4 1.6 3.1 0.0 -1.8
Trunk predicted mass 1.7 9.5 11.1 -2.8 -3.3
Standing height 5.5 54.2 67.4 -6.4 -8.2
Length of working week for main job 0.5 0.5 0.9 -0.2 -1.0
Exposure to tobacco smoke at home 0.0 0.0 0.1 0.2 0.0
Breastfed as a baby 1.4 1.8 2.4 1.0 1.6
Tense / ‘highly strung’ 0.4 0.6 1.2 1.1 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.3 0.5 -0.6
Hair/balding pattern: Pattern 4 23.5 56.9 77.9 -6.0 -8.8
Birth weight of first child 1.9 3.5 6.8 0.4 2.6
Peak expiratory flow (PEF) 0.3 0.7 1.4 1.2 0.1
Pulse wave reflection index 0.7 0.9 1.8 1.3 -0.0
Ever highly irritable/argumentative for 2 days 3.6 4.3 7.6 -1.0 -2.8
Loud music exposure frequency 0.1 0.1 0.2 -0.0 -0.4
Qualifications: O levels/GCSEs or equivalent 0.0 0.1 0.1 0.2 0.3
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 2.1 0.7 -1.4
Blood clot in the leg (DVT) 1.4 1.8 3.5 1.9 -0.2
Medication: Paracetamol 2.4 4.0 6.3 -1.3 -2.5
Headache pain in last month 0.3 0.5 0.6 0.7 -0.7
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.4 -0.5 -0.6
Glaucoma (self-reported) 1.6 1.9 2.7 -1.1 -1.6
Gout (self-reported) 0.9 1.2 1.9 0.7 1.4
Hypothyroidism/myxoedema (self-reported) 10.9 21.3 26.5 5.1 4.0
Medication: Amlodipine 0.6 0.9 1.3 0.7 1.1
Medication: Ventolin 100micrograms inhaler 1.6 2.1 4.0 0.3 2.0
Birth weight 2.6 5.7 11.4 -3.4 0.0
Chronic bronchitis/emphysema (mother) 2.2 2.6 3.1 1.4 1.8
High blood pressure (siblings) 0.2 0.3 0.4 -0.6 0.4
Forced vital capacity (FVC), Best measure 2.4 8.9 12.5 -3.5 -2.3
Body fat percentage 0.8 3.0 5.9 0.1 -2.4
Leg fat percentage (right) 0.6 2.3 4.6 -0.2 -2.1
Arm fat-free mass (right) 1.2 6.0 8.3 -1.9 -2.9
Exposure to tobacco smoke outside home 0.1 0.2 0.3 -0.1 -0.6
Comparative body size at age 10 1.7 4.7 7.5 1.4 -2.7
Number of full brothers 0.6 0.8 1.5 -1.2 0.2
Worry too long after embarrassment 0.2 0.3 0.3 0.5 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.2 -0.4 -0.4
Wheeze or whistling in the chest in last year 0.1 0.2 0.3 -0.6 -0.2
Number of children fathered 0.4 0.5 0.7 -0.8 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.0 0.0 0.0
Age at first live birth 0.5 0.9 1.2 -0.8 1.1
Pulse wave peak to peak time 1.4 1.7 3.1 -1.8 0.5
Health satisfaction 1.3 1.7 2.1 -1.2 -1.4
Shortness of breath walking on level ground 0.6 0.7 1.2 -1.1 -0.5
Qualifications: College or University degree 2.4 7.4 9.5 -3.1 -2.3
Eye problems/disorders: None of the above 0.7 0.8 1.3 -1.1 0.5
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.5 0.7 -0.1
Emphysema/chronic bronchitis 2.2 2.5 4.9 -2.2 -0.2
Medication for pain relief, constipation, heartburn 1.0 1.7 3.3 0.3 1.8
Neck or shoulder pain in last month 1.8 2.5 4.3 2.1 0.9
Medication: Blood pressure 0.4 0.7 1.3 -1.1 0.3
Angina (self-reported) 0.1 0.2 0.3 0.3 0.5
Migraine (self-reported) 0.7 0.8 1.6 1.3 -0.2
Medication: Ibuprofen 0.7 0.8 1.1 1.0 0.7
Medication: Allopurinol 0.3 0.4 0.8 0.2 0.9
Medication: Omeprazole 2.9 3.5 6.5 -0.7 -2.5
Medication: Seretide 50 evohaler 5.9 6.8 13.0 -3.6 -0.7
Mean time to correctly identify matches 0.1 0.3 0.5 -0.1 -0.7
Heart disease (mother) 0.5 0.6 0.9 0.5 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.6 2.2 1.5 1.0
Whole body fat mass 1.1 4.6 8.9 -0.5 -3.0
Leg fat mass (right) 1.2 4.5 8.5 -0.7 -2.9
Arm predicted mass (right) 1.2 6.3 9.3 -1.8 -3.0
Pulse rate, automated reading 0.5 1.6 2.6 -1.6 -0.8
Alcohol intake frequency. 0.9 2.1 4.0 2.0 0.6
Comparative height size at age 10 6.4 35.3 53.1 -4.2 -7.3
Number of full sisters 1.1 1.3 1.9 -1.4 -0.9
Suffer from ‘nerves’ 3.7 5.8 7.6 2.8 2.0
Overall health rating 0.7 1.4 2.3 -0.8 -1.5
Chest pain or discomfort 1.1 1.6 2.1 -1.1 1.4
Had major operations 0.6 0.7 1.3 -1.1 -0.1
Age at last live birth 0.2 0.3 0.5 -0.7 -0.3
Family relationship satisfaction 5.3 6.5 9.0 -2.0 -3.0
Leg pain on walking 2.2 2.8 3.3 -1.5 -1.8
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.1 2.8 -1.1 -1.7
Commuting to job workplace: Car/motor vehicle 0.9 1.0 1.6 -0.6 1.2
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 1.5 0.5 1.2
Medication: Aspirin 0.6 0.7 1.5 0.1 -1.2
Supplements: Vitamin C 0.9 1.1 2.2 1.5 0.1
Knee pain experienced in last month 0.2 0.4 0.7 0.8 -0.1
Hypertension (Self-reported) 0.0 0.1 0.1 -0.3 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 1.4 -1.2 -1.1
Illnesses of father: Heart disease 0.4 0.6 0.7 -0.7 -0.8
Illnesses of siblings: Diabetes 0.6 0.7 1.3 0.2 1.2
Smoking status: Previous 3.2 4.8 5.7 2.0 2.4
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 1.7 -1.3 -1.3
Whole body fat-free mass 1.0 5.8 7.4 -2.1 -2.7
Leg fat-free mass (right) 0.3 1.5 2.0 -1.0 -1.4
Arm fat percentage (left) 0.2 0.8 1.0 1.0 -0.8
Average weekly red wine intake 0.0 0.0 0.1 -0.3 0.0
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.4 -0.6 -0.1
Mood swings 1.4 2.6 5.2 2.3 0.2
Loneliness, isolation 0.7 1.0 1.6 1.3 -0.7
Long-standing illness, disability or infirmity 0.3 0.4 0.5 -0.5 -0.7
Ever had bowel cancer screening 0.6 0.7 1.4 -0.0 -1.2
Diabetes diagnosed by doctor 0.2 0.4 0.6 -0.4 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 1.7 -0.4 -1.3
Friendships satisfaction 3.7 4.6 7.2 -1.4 -2.7
Qualifications: nursing, teaching 0.9 1.3 2.1 1.4 0.8
Commuting to job workplace: Walk 0.0 0.0 0.0 0.1 -0.2
Eye problems/disorders: Cataract 0.6 0.7 1.3 1.1 0.4
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 0.8 0.8 0.9
Medication for cholesterol 1.8 2.7 5.4 0.0 2.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.5 1.9 -1.4 -1.0
Back pain experienced in last month 0.4 0.6 0.9 1.0 -0.5
Mineral and other dietary supplements 0.2 0.3 0.5 0.7 0.3
Breast cancer (self-reported) 0.6 0.7 1.1 1.1 0.5
Asthma (self-reported) 0.8 1.6 1.7 -1.3 1.2
Osteoporosis (self-reported) 1.1 1.4 1.6 -1.3 -1.0
Osteoarthritis (self-reported) 0.8 1.0 1.7 1.3 0.6
Medication: Aspirin 0.7 0.9 1.6 0.5 -1.3
Medication: Gliclazide 1.0 1.2 2.2 1.5 0.4
Illnesses of father: None of the above (group 1) 0.0 0.0 0.1 0.1 0.3
Smoking status: Current 2.6 4.1 7.0 -1.1 -2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 2.6 1.1 1.6
Whole body water mass 0.9 5.0 6.5 -1.9 -2.5
Leg predicted mass (right) 0.3 1.6 2.2 -1.0 -1.5
Arm fat mass (left) 0.4 1.7 3.3 -0.1 -1.8
Number of self-reported non-cancer illnesses 0.2 0.3 0.6 -0.8 -0.3
Average weekly champagne plus white wine intake 2.7 3.7 7.2 2.7 -0.3
Miserableness 0.2 0.3 0.5 0.7 -0.3
Guilty feelings 0.1 0.2 0.3 0.0 -0.6
Wears glasses or contact lenses 0.0 0.0 0.1 -0.0 -0.3
Ever taken oral contraceptive pill 1.6 1.8 3.5 0.1 1.9
Hearing aid user 0.3 0.4 0.5 -0.7 0.5
Mother’s age at death 0.1 0.1 0.2 0.1 -0.4
Financial situation satisfaction 2.3 2.8 3.5 -1.5 -1.9
Tinnitus: Yes, now most or all of the time 1.8 2.1 3.6 0.8 1.9
Commuting to job workplace: Public transport 0.9 1.0 1.3 -0.8 -1.2
Eye problems/disorders: Glaucoma 0.8 1.0 1.8 -0.5 -1.3
Medication: Blood pressure 0.9 1.8 3.1 0.7 -1.8
Pain type(s) experienced in last month: Hip pain 2.2 2.8 4.8 2.2 0.9
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.2 0.5 1.1
High cholesterol (Self-reported) 0.5 1.0 1.9 1.4 -0.1
Medication: Bendroflumethiazide 2.7 4.2 6.2 -1.4 -2.5
Medication: Paracetamol 1.0 1.6 2.8 -0.6 -1.7
Medication: Lisinopril 2.1 2.7 3.1 -1.5 -1.8
Medication: Atorvastatin 0.7 0.9 1.8 -0.2 -1.3
Illnesses of father: High blood pressure 1.7 2.1 3.6 1.9 0.8
Alcohol drinker status: Never 0.1 0.1 0.3 0.5 0.1
Ever smoked 1.0 1.8 3.6 1.9 0.3
Basal metabolic rate 1.2 6.6 8.8 -2.1 -3.0
Leg fat percentage (left) 0.6 2.1 4.2 0.2 -2.1
Arm fat-free mass (left) 1.5 7.4 10.2 -2.2 -3.2
Number of operations (self-reported) 1.4 2.1 2.2 1.4 1.5
Average weekly beer plus cider intake 1.4 2.0 4.0 -2.0 -0.0
Irritability 2.0 3.3 6.6 2.6 0.2
Risk taking 1.1 1.7 2.4 -1.0 -1.5
Ever had prostate specific antigen (PSA) test 1.4 1.6 3.0 0.5 1.7
Fractured/broken bones in last 5 years 2.2 2.8 4.2 -1.2 -2.0
Age started oral contraceptive pill 0.1 0.1 0.3 0.5 0.2
Diastolic blood pressure, automated reading 0.2 0.6 0.7 0.9 -0.7
Ever depressed for a whole week 1.4 1.7 2.9 0.7 -1.7
Unable to work because of sickness or disability 0.0 0.0 0.1 -0.1 -0.3
Commuting to job workplace: Cycle 0.0 0.0 0.0 0.1 0.1
Myopia 3.7 5.3 7.4 2.7 1.8
Vascular/heart problems diagnosed by doctor 0.2 0.4 0.8 0.2 0.9
Cholesterol lowering medication 0.9 1.4 2.7 0.2 -1.6
Medication: Omeprazole (e.g. Zanprol) 2.5 3.0 5.8 -0.5 -2.4
Pain experienced in last month 0.9 1.5 1.5 -1.2 1.2
Supplements: Calcium 0.2 0.2 0.2 0.4 0.4
Basal cell carcinoma (self-reported) 0.6 0.7 1.2 -1.1 0.4
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.6 1.3 0.3
Deep venous thrombosis (DVT) (self-reported) 1.9 2.5 4.9 2.2 -0.2
Heart disease (siblings) 0.3 0.3 0.5 -0.4 -0.7
Alcohol drinker status: Previous 0.1 0.2 0.2 0.3 0.5
Pack years of smoking 1.8 2.6 3.4 -1.8 -1.4
Impedance of whole body 1.7 8.7 13.5 -2.0 -3.7
Leg fat mass (left) 1.0 4.0 7.7 -0.4 -2.8
Arm predicted mass (left) 1.5 7.4 10.1 -2.2 -3.2