TWAS hub - CTCF

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Nucleus accumbens basal ganglia	0.1110	0.0560	0.0031	0.033	NA	0.000	NA	0.045	0.0450	NA	0.32	NA	0.0240
2	METSIM	Adipose	0.0308	0.0187	0.0055	0.017	0.011	0.002	0.013	0.011	0.0011	0.0066	0.17	0.0034	0.0064

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hair/balding pattern: Pattern 4	23.5	56.9	77.9	-6.0	-8.8
Lung FEV1/FVC ratio	14.3	72.6	128.2	11.3	4.1
Hypothyroidism (self reported)	13.7	31.4	39.8	6.3	4.8
Hypothyroidism/myxoedema (self-reported)	10.9	21.3	26.5	5.1	4.0
Medication: Levothyroxine sodium	10.4	17.6	18.8	4.3	4.1
HDL Cholesterol	9.4	15.7	28.7	5.4	-1.6
Waist Hip Ratio (WHR)	7.2	32.2	33.4	-5.8	-5.6
Qualifications: CSEs or equivalent	6.5	8.6	9.1	2.9	3.0
Bipolar Disorder or Schizophrenia	6.4	15.6	24.9	5.0	2.5
Comparative height size at age 10	6.4	35.3	53.1	-4.2	-7.3
Blood Red Count	6.0	57.7	90.2	9.5	5.0
Medication: Seretide 50 evohaler	5.9	6.8	13.0	-3.6	-0.7
Standing height	5.5	54.2	67.4	-6.4	-8.2
Alzheimer’s Disease (in father)	5.4	5.8	8.5	1.8	2.9
Family relationship satisfaction	5.3	6.5	9.0	-2.0	-3.0
Fasting Glucose	4.9	5.9	10.7	-3.3	-1.0
Happiness	4.9	6.0	7.9	-2.0	-2.8
Ovarian Cancer	4.8	6.4	12.7	-3.6	-0.2
Schizophrenia (2018)	4.7	9.9	16.9	4.1	1.7
Serious illness, injury or assault to yourself	4.7	5.7	7.5	-2.7	-2.0
Alcohol intake versus 10 years previously	4.6	6.9	7.3	-2.6	-2.7
Alcohol usually taken with meals	4.5	7.3	10.5	3.2	2.0
Bipolar Disorder (2018)	3.8	6.0	8.0	2.8	2.0
Schizophrenia (2014)	3.8	8.4	15.7	4.0	1.1
Heel T-Score	3.8	30.3	44.8	4.0	6.7
Forced vital capacity (FVC)	3.8	14.7	19.8	-4.5	-3.1
Falls in the last year	3.7	5.0	9.3	-3.0	-0.8
Suffer from ‘nerves’	3.7	5.8	7.6	2.8	2.0
Friendships satisfaction	3.7	4.6	7.2	-1.4	-2.7
Myopia	3.7	5.3	7.4	2.7	1.8
Height	3.6	68.9	85.7	-7.2	-9.3
Ever highly irritable/argumentative for 2 days	3.6	4.3	7.6	-1.0	-2.8
Smoking status: Previous	3.2	4.8	5.7	2.0	2.4
Impedance of leg (right)	3.1	14.9	21.2	-2.9	-4.6
Time employed in main current job	3.1	3.6	5.4	1.3	2.3
Impedance of leg (left)	2.9	13.9	21.7	-2.5	-4.7
Medication: Omeprazole	2.9	3.5	6.5	-0.7	-2.5
Average weekly spirits intake	2.8	3.4	6.0	-2.5	-0.9
Current tobacco smoking	2.7	4.4	7.4	-1.2	-2.7
Average weekly champagne plus white wine intake	2.7	3.7	7.2	2.7	-0.3
Medication: Bendroflumethiazide	2.7	4.2	6.2	-1.4	-2.5
Waist circumference	2.6	9.4	12.5	-2.5	-3.5
Financial difficulties in last 2 years	2.6	3.4	6.3	-0.7	-2.5
Birth weight	2.6	5.7	11.4	-3.4	0.0
Smoking status: Current	2.6	4.1	7.0	-1.1	-2.6
Medication: Omeprazole (e.g. Zanprol)	2.5	3.0	5.8	-0.5	-2.4
Medication: Paracetamol	2.4	4.0	6.3	-1.3	-2.5
Forced vital capacity (FVC), Best measure	2.4	8.9	12.5	-3.5	-2.3
Qualifications: College or University degree	2.4	7.4	9.5	-3.1	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	2.3	5.2	10.2	0.4	3.2
Financial situation satisfaction	2.3	2.8	3.5	-1.5	-1.9
Chronotype (morning person)	2.2	5.2	5.2	-2.3	-2.3
Chronic bronchitis/emphysema (mother)	2.2	2.6	3.1	1.4	1.8
Emphysema/chronic bronchitis	2.2	2.5	4.9	-2.2	-0.2
Leg pain on walking	2.2	2.8	3.3	-1.5	-1.8
Pain type(s) experienced in last month: Hip pain	2.2	2.8	4.8	2.2	0.9
Fractured/broken bones in last 5 years	2.2	2.8	4.2	-1.2	-2.0
Medication: Lisinopril	2.1	2.7	3.1	-1.5	-1.8
Mean Putamen Volume	2.0	2.3	3.8	0.9	1.9
Nervous feelings	2.0	3.7	3.8	1.9	1.9
Irritability	2.0	3.3	6.6	2.6	0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.3	8.1	0.7	2.8
Hair/balding pattern: Pattern 3	1.9	2.9	4.9	0.9	2.2
Birth weight of first child	1.9	3.5	6.8	0.4	2.6
Deep venous thrombosis (DVT) (self-reported)	1.9	2.5	4.9	2.2	-0.2
Schizophrenia vs Biploar Disorder	1.8	2.4	2.8	1.7	-1.4
Primary Biliary Cirrhosis	1.8	2.6	4.2	1.1	-2.0
Pack years adult smoking proportion	1.8	2.8	3.5	-1.9	-1.4
Supplements: Glucosamine	1.8	2.3	3.9	-2.0	-0.8
Fluid intelligence score	1.8	3.7	7.5	-2.7	-0.1
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.0	3.5	-1.9	-0.7
Neck or shoulder pain in last month	1.8	2.5	4.3	2.1	0.9
Medication for cholesterol	1.8	2.7	5.4	0.0	2.3
Tinnitus: Yes, now most or all of the time	1.8	2.1	3.6	0.8	1.9
Pack years of smoking	1.8	2.6	3.4	-1.8	-1.4
Number of incorrect matches in round	1.7	2.8	5.6	-0.4	-2.4
Trunk predicted mass	1.7	9.5	11.1	-2.8	-3.3
Comparative body size at age 10	1.7	4.7	7.5	1.4	-2.7
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	2.8	-1.1	-1.7
Illnesses of father: High blood pressure	1.7	2.1	3.6	1.9	0.8
Impedance of whole body	1.7	8.7	13.5	-2.0	-3.7
Supplements: Zinc	1.6	1.8	2.7	1.6	0.9
Trunk fat-free mass	1.6	9.3	11.1	-2.8	-3.3
Glaucoma (self-reported)	1.6	1.9	2.7	-1.1	-1.6
Medication: Ventolin 100micrograms inhaler	1.6	2.1	4.0	0.3	2.0
Ever taken oral contraceptive pill	1.6	1.8	3.5	0.1	1.9
Prostate Cancer	1.5	2.2	4.2	-2.1	-0.3
Trunk fat mass	1.5	6.4	12.0	-0.9	-3.5
Arm fat-free mass (left)	1.5	7.4	10.2	-2.2	-3.2
Arm predicted mass (left)	1.5	7.4	10.1	-2.2	-3.2
Body Mass Index (BMI) (2010)	1.4	1.9	2.1	1.3	1.5
Neuroticism (2016)	1.4	2.1	4.0	2.0	-0.4
Hearing difficulty/problems: Yes	1.4	2.1	4.2	-0.2	2.1
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	2.7	1.6	0.7
Stomach or abdominal pain in last month	1.4	1.8	3.2	1.8	0.6
Pulse wave Arterial Stiffness index	1.4	1.6	1.9	1.1	-1.4
Breastfed as a baby	1.4	1.8	2.4	1.0	1.6
Blood clot in the leg (DVT)	1.4	1.8	3.5	1.9	-0.2
Pulse wave peak to peak time	1.4	1.7	3.1	-1.8	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	2.2	1.5	1.0
Mood swings	1.4	2.6	5.2	2.3	0.2
Number of operations (self-reported)	1.4	2.1	2.2	1.4	1.5
Average weekly beer plus cider intake	1.4	2.0	4.0	-2.0	-0.0
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.0	0.5	1.7
Ever depressed for a whole week	1.4	1.7	2.9	0.7	-1.7
Intelligence (Savage-Jansen 2018)	1.3	4.1	8.2	-2.9	0.2
Number of live births	1.3	1.9	2.5	1.6	1.2
Prospective memory result	1.3	1.6	3.2	1.8	-0.2
Health satisfaction	1.3	1.7	2.1	-1.2	-1.4
Maternal smoking around birth	1.2	1.7	1.9	-1.2	-1.4
Weight	1.2	6.1	9.6	-1.6	-3.1
Arm fat-free mass (right)	1.2	6.0	8.3	-1.9	-2.9
Leg fat mass (right)	1.2	4.5	8.5	-0.7	-2.9
Arm predicted mass (right)	1.2	6.3	9.3	-1.8	-3.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	1.9	-1.4	-1.0
Basal metabolic rate	1.2	6.6	8.8	-2.1	-3.0
Worry (Nagel 2018)	1.1	2.4	4.3	2.1	0.7
Blood Eosinophil Count	1.1	8.6	16.7	0.6	-4.1
Blood White Count	1.1	8.2	9.5	-2.6	-3.1
Medication: Co-codamol	1.1	1.2	2.2	1.5	0.6
Multivitamins +/- minerals	1.1	1.4	1.7	1.3	1.0
Qualifications: A levels/AS levels or equivalent	1.1	2.4	3.9	-2.0	-0.9
Whole body fat mass	1.1	4.6	8.9	-0.5	-3.0
Number of full sisters	1.1	1.3	1.9	-1.4	-0.9
Chest pain or discomfort	1.1	1.6	2.1	-1.1	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	1.4	-1.2	-1.1
Osteoporosis (self-reported)	1.1	1.4	1.6	-1.3	-1.0
Risk taking	1.1	1.7	2.4	-1.0	-1.5
Neuroticism (Nagel 2018)	1.0	2.3	4.5	2.1	-0.2
Coronary Artery Disease (CAD)	1.0	1.2	1.5	-1.2	-0.9
Crohns Disease (2012)	1.0	1.6	2.3	-1.5	-0.9
Lung FVC	1.0	5.3	10.6	-3.3	-0.1
Neuroticism	1.0	2.5	5.0	2.2	0.0
Ever had hysterectomy (womb removed)	1.0	1.1	2.2	0.2	-1.5
High blood pressure (mother)	1.0	1.4	1.5	1.2	1.1
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	2.4	-1.5	-0.6
Father’s age at death	1.0	1.3	2.4	1.6	0.5
Asthma	1.0	2.0	3.0	-1.0	1.7
Medication: Cholesterol lowering	1.0	1.5	2.3	1.5	0.9
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.1	0.7	-1.4
Medication for pain relief, constipation, heartburn	1.0	1.7	3.3	0.3	1.8
Whole body fat-free mass	1.0	5.8	7.4	-2.1	-2.7
Medication: Gliclazide	1.0	1.2	2.2	1.5	0.4
Medication: Paracetamol	1.0	1.6	2.8	-0.6	-1.7
Ever smoked	1.0	1.8	3.6	1.9	0.3
Leg fat mass (left)	1.0	4.0	7.7	-0.4	-2.8
Reaction Time	0.9	1.8	2.8	-0.9	-1.7
Trunk fat percentage	0.9	3.7	7.4	0.0	-2.7
Medication: Atenolol	0.9	1.1	2.2	0.3	-1.5
Neuroticism score	0.9	1.9	3.8	1.9	0.2
Pulse rate	0.9	1.5	1.5	-1.2	-1.2
Gout (self-reported)	0.9	1.2	1.9	0.7	1.4
Alcohol intake frequency.	0.9	2.1	4.0	2.0	0.6
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.6	-0.6	1.2
Supplements: Vitamin C	0.9	1.1	2.2	1.5	0.1
Qualifications: nursing, teaching	0.9	1.3	2.1	1.4	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	2.6	1.1	1.6
Whole body water mass	0.9	5.0	6.5	-1.9	-2.5
Commuting to job workplace: Public transport	0.9	1.0	1.3	-0.8	-1.2
Medication: Blood pressure	0.9	1.8	3.1	0.7	-1.8
Cholesterol lowering medication	0.9	1.4	2.7	0.2	-1.6
Pain experienced in last month	0.9	1.5	1.5	-1.2	1.2
Breast Cancer	0.8	2.0	4.0	-2.0	0.2
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.8	0.2	1.4
Sitting height	0.8	5.6	5.7	-2.4	-2.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.5	1.6	0.1
Had other major operations	0.8	1.0	2.0	1.4	0.2
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.3	0.8	-1.1
Impedance of arm (right)	0.8	3.9	6.9	-1.0	-2.6
Body fat percentage	0.8	3.0	5.9	0.1	-2.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	1.7	-1.3	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.7	-0.4	-1.3
Asthma (self-reported)	0.8	1.6	1.7	-1.3	1.2
Osteoarthritis (self-reported)	0.8	1.0	1.7	1.3	0.6
Eye problems/disorders: Glaucoma	0.8	1.0	1.8	-0.5	-1.3
Depressed Affect (Nagel 2018)	0.7	1.4	2.5	1.6	-0.6
Crohns Disease (2017)	0.7	1.4	2.3	-1.5	-0.7
Verbal and Numeric Reasoning (VNR)	0.7	1.6	3.1	-1.8	0.3
Blood Platelet Count	0.7	8.0	9.8	-2.5	-3.1
Vitamin and mineral supplements	0.7	0.9	1.4	-1.2	-0.7
Pulse wave reflection index	0.7	0.9	1.8	1.3	-0.0
Eye problems/disorders: None of the above	0.7	0.8	1.3	-1.1	0.5
Migraine (self-reported)	0.7	0.8	1.6	1.3	-0.2
Medication: Ibuprofen	0.7	0.8	1.1	1.0	0.7
Overall health rating	0.7	1.4	2.3	-0.8	-1.5
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.5	0.5	1.2
Loneliness, isolation	0.7	1.0	1.6	1.3	-0.7
Medication: Aspirin	0.7	0.9	1.6	0.5	-1.3
Medication: Atorvastatin	0.7	0.9	1.8	-0.2	-1.3
Alzheimer’s Disease (in mother)	0.6	0.7	0.9	-0.7	-1.0
Lupus	0.6	0.9	1.3	1.1	-0.7
Past tobacco smoking	0.6	1.1	1.6	-1.3	-0.8
Heart attack	0.6	0.8	1.4	1.2	0.5
Medication: Lansoprazole	0.6	0.6	1.1	0.4	-1.1
Impedance of arm (left)	0.6	2.9	4.9	-1.0	-2.2
Medication: Amlodipine	0.6	0.9	1.3	0.7	1.1
Leg fat percentage (right)	0.6	2.3	4.6	-0.2	-2.1
Number of full brothers	0.6	0.8	1.5	-1.2	0.2
Shortness of breath walking on level ground	0.6	0.7	1.2	-1.1	-0.5
Had major operations	0.6	0.7	1.3	-1.1	-0.1
Medication: Aspirin	0.6	0.7	1.5	0.1	-1.2
Illnesses of siblings: Diabetes	0.6	0.7	1.3	0.2	1.2
Ever had bowel cancer screening	0.6	0.7	1.4	-0.0	-1.2
Eye problems/disorders: Cataract	0.6	0.7	1.3	1.1	0.4
Breast cancer (self-reported)	0.6	0.7	1.1	1.1	0.5
Leg fat percentage (left)	0.6	2.1	4.2	0.2	-2.1
Basal cell carcinoma (self-reported)	0.6	0.7	1.2	-1.1	0.4
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.6	1.3	0.3
Rheumatoid Arthritis	0.5	0.6	1.2	0.2	1.1
BMI	0.5	3.0	5.5	2.3	0.7
Allergy or Eczema	0.5	1.3	2.4	-1.5	0.5
Respiratory disease	0.5	1.2	1.4	-1.0	1.2
Hair Pigment	0.5	13.5	18.8	4.3	2.8
Number of treatments/medications taken	0.5	0.8	1.0	1.0	-0.8
Sensitivity / hurt feelings	0.5	0.9	1.8	-0.1	-1.3
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.1	1.1	0.6
Fed-up feelings	0.5	0.9	1.8	1.4	0.2
Lung cancer (father)	0.5	0.6	1.1	1.1	-0.3
Length of working week for main job	0.5	0.5	0.9	-0.2	-1.0
Age at first live birth	0.5	0.9	1.2	-0.8	1.1
Heart disease (mother)	0.5	0.6	0.9	0.5	-1.0
Pulse rate, automated reading	0.5	1.6	2.6	-1.6	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	0.8	0.8	0.9
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.2	0.5	1.1
High cholesterol (Self-reported)	0.5	1.0	1.9	1.4	-0.1
Age at First Birth	0.4	0.5	0.6	-0.6	0.8
Cardiovascular Disease	0.4	1.2	2.4	-0.2	-1.5
Type 2 Diabetes (T2D) (2018)	0.4	0.8	0.9	-1.0	-0.8
Medication for hormone replacement therapy	0.4	0.5	0.5	-0.6	-0.7
Diabetes (father)	0.4	0.5	0.5	0.7	-0.7
Severe depression (siblings)	0.4	0.5	0.6	0.8	-0.6
Leg fat-free mass (left)	0.4	2.2	2.9	-1.2	-1.7
Taking other prescription medications	0.4	0.6	1.1	1.1	-0.3
Leg predicted mass (left)	0.4	2.3	3.0	-1.2	-1.7
Illnesses of siblings	0.4	0.6	0.9	1.0	0.5
Arm fat mass (right)	0.4	1.6	3.1	0.0	-1.8
Tense / ‘highly strung’	0.4	0.6	1.2	1.1	0.1
Number of children fathered	0.4	0.5	0.7	-0.8	0.5
Medication: Blood pressure	0.4	0.7	1.3	-1.1	0.3
Illnesses of father: Heart disease	0.4	0.6	0.7	-0.7	-0.8
Back pain experienced in last month	0.4	0.6	0.9	1.0	-0.5
Arm fat mass (left)	0.4	1.7	3.3	-0.1	-1.8
Depression (Nagel 2018)	0.3	0.5	0.7	0.6	-0.8
Major Depression (MDD)	0.3	0.4	0.8	0.9	0.0
LDL Cholesterol	0.3	0.5	0.9	0.3	0.9
Triglycerides	0.3	0.5	0.6	-0.6	0.8
Smoking Status	0.3	0.7	1.0	1.0	-0.6
Diabetes (mother)	0.3	0.4	0.6	0.8	0.4
Had menopause	0.3	0.4	0.9	-0.1	-0.9
Mouth/teeth dental problems	0.3	0.4	0.6	-0.8	-0.5
Diabetes (self-reported)	0.3	0.5	0.7	-0.5	-0.9
Peak expiratory flow (PEF)	0.3	0.7	1.4	1.2	0.1
Headache pain in last month	0.3	0.5	0.6	0.7	-0.7
Medication: Allopurinol	0.3	0.4	0.8	0.2	0.9
Leg fat-free mass (right)	0.3	1.5	2.0	-1.0	-1.4
Long-standing illness, disability or infirmity	0.3	0.4	0.5	-0.5	-0.7
Leg predicted mass (right)	0.3	1.6	2.2	-1.0	-1.5
Hearing aid user	0.3	0.4	0.5	-0.7	0.5
Heart disease (siblings)	0.3	0.3	0.5	-0.4	-0.7
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	0.2	0.7
Irritable Bowel Disease (IBD)	0.2	0.6	0.7	-0.7	-0.8
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	-0.2	-0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	-0.6	-0.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.2	-0.5
Medication: Metformin	0.2	0.3	0.3	0.5	0.6
Townsend deprivation index at recruitment	0.2	0.3	0.4	-0.3	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	0.8	0.0
Relative age voice broke	0.2	0.3	0.5	0.4	0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	0.3	0.5
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.7	-0.0	0.8
Chronic bronchitis/emphysema (father)	0.2	0.3	0.6	-0.8	0.1
Body mass index (BMI)	0.2	1.1	1.8	1.4	0.5
Allergy	0.2	0.6	1.1	-0.2	-1.0
Medication: Simvastatin	0.2	0.3	0.5	0.4	-0.7
Arm fat percentage (right)	0.2	0.8	1.2	1.1	-0.6
Hip circumference	0.2	0.7	1.4	-0.2	-1.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.3	-0.5	-1.1
Mouth/teeth dental problems: Dentures	0.2	0.4	0.7	-0.2	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.3	0.5	-0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.4	-0.5	-0.6
High blood pressure (siblings)	0.2	0.3	0.4	-0.6	0.4
Worry too long after embarrassment	0.2	0.3	0.3	0.5	0.6
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	0.7	-0.1
Age at last live birth	0.2	0.3	0.5	-0.7	-0.3
Knee pain experienced in last month	0.2	0.4	0.7	0.8	-0.1
Arm fat percentage (left)	0.2	0.8	1.0	1.0	-0.8
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	-0.6	-0.1
Diabetes diagnosed by doctor	0.2	0.4	0.6	-0.4	-0.8
Mineral and other dietary supplements	0.2	0.3	0.5	0.7	0.3
Number of self-reported non-cancer illnesses	0.2	0.3	0.6	-0.8	-0.3
Miserableness	0.2	0.3	0.5	0.7	-0.3
Diastolic blood pressure, automated reading	0.2	0.6	0.7	0.9	-0.7
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.8	0.2	0.9
Supplements: Calcium	0.2	0.2	0.2	0.4	0.4
Ulcerative Colitis (UC)	0.1	0.3	0.4	0.7	-0.3
HbA1C	0.1	0.1	0.2	-0.3	0.5
Relative age of first facial hair	0.1	0.3	0.6	-0.8	0.2
Hand grip strength (right)	0.1	0.2	0.2	0.4	0.4
Average weekly fortified wine intake	0.1	0.1	0.2	-0.3	-0.5
High blood pressure	0.1	0.4	0.4	-0.7	-0.6
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.1	0.5
Qualifications: None of the above	0.1	0.2	0.4	-0.6	-0.3
Pain all over the body in last month	0.1	0.1	0.3	0.5	0.1
Medication: Ramipril	0.1	0.1	0.2	-0.1	-0.5
Worrier / anxious feelings	0.1	0.3	0.5	0.7	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.4	-0.4	-0.6
Loud music exposure frequency	0.1	0.1	0.2	-0.0	-0.4
Exposure to tobacco smoke outside home	0.1	0.2	0.3	-0.1	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.2	-0.4	-0.4
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	-0.6	-0.2
Angina (self-reported)	0.1	0.2	0.3	0.3	0.5
Mean time to correctly identify matches	0.1	0.3	0.5	-0.1	-0.7
Guilty feelings	0.1	0.2	0.3	0.0	-0.6
Mother’s age at death	0.1	0.1	0.2	0.1	-0.4
Alcohol drinker status: Never	0.1	0.1	0.3	0.5	0.1
Age started oral contraceptive pill	0.1	0.1	0.3	0.5	0.2
Alcohol drinker status: Previous	0.1	0.2	0.2	0.3	0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.0	-0.0	0.1
Systolic Blood Pressure	0.0	0.0	0.0	0.1	0.0
Tanning	0.0	0.3	0.5	0.4	-0.7
Hand grip strength (left)	0.0	0.1	0.2	0.2	0.5
Systolic blood pressure, automated reading	0.0	0.0	0.0	0.1	0.2
Angina	0.0	0.1	0.1	0.0	0.3
Age when periods started (menarche)	0.0	0.1	0.2	0.2	-0.4
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	0.0	0.2
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	0.3	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.1	-0.2	-0.0
Noisy workplace	0.0	0.0	0.0	-0.1	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.0	0.1	0.1
Depression (self-reported)	0.0	0.0	0.0	0.2	-0.1
Illnesses of mother	0.0	0.1	0.1	-0.2	0.3
Exposure to tobacco smoke at home	0.0	0.0	0.1	0.2	0.0
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.1	0.2	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	0.0	0.0
Hypertension (Self-reported)	0.0	0.1	0.1	-0.3	-0.4
Average weekly red wine intake	0.0	0.0	0.1	-0.3	0.0
Commuting to job workplace: Walk	0.0	0.0	0.0	0.1	-0.2
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	0.1	0.3
Wears glasses or contact lenses	0.0	0.0	0.1	-0.0	-0.3
Unable to work because of sickness or disability	0.0	0.0	0.1	-0.1	-0.3
Commuting to job workplace: Cycle	0.0	0.0	0.0	0.1	0.1

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