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chr3:51,616,334-53,778,875

Best TWAS P=1.2e-08 · Best GWAS P=8.94e-08 conditioned to 0.571

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Aorta	GNL3	0.12	0.15	lasso	5	0.14	4.7e-08	-5.2	5.6	1.8e-08	0.80	0.07	0.93	FALSE
2	GTEx	Artery Aorta	TMEM110	0.19	0.08	enet	16	0.10	6.0e-06	-4.6	-5.2	1.6e-07	-0.69	0.15	0.84	FALSE
3	GTEx	Artery Coronary	TMEM110	0.17	0.05	lasso	8	0.07	3.1e-03	3.8	-5.2	1.8e-07	-0.62	0.10	0.58	FALSE
4	GTEx	Artery Tibial	GNL3	0.08	0.06	lasso	3	0.06	3.0e-05	5.0	5.4	6.7e-08	0.94	0.11	0.88	FALSE
5	GTEx	Brain Cerebellum	GNL3	0.14	0.07	enet	43	0.09	1.3e-03	-4.7	5.3	1.1e-07	0.88	0.19	0.69	FALSE
6	GTEx	Brain Hippocampus	GLYCTK-AS1	0.17	0.25	lasso	6	0.15	1.9e-04	-5.3	5.2	2.5e-07	0.78	0.04	0.92	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	TMEM110	0.13	0.07	lasso	3	0.05	1.5e-02	-4.6	-5.2	2.4e-07	-0.70	0.07	0.51	FALSE
8	GTEx	Breast Mammary Tissue	NT5DC2	0.13	0.12	enet	11	0.08	9.9e-05	5.1	5.2	2.0e-07	0.92	0.07	0.90	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	ITIH4-AS1	0.11	0.05	enet	10	0.02	5.1e-02	5.1	-5.3	1.4e-07	-0.82	0.07	0.69	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	RP5-966M1.6	0.16	0.07	enet	19	0.11	1.8e-04	-4.9	-5.6	2.1e-08	-0.89	0.10	0.87	FALSE
11	GTEx	Esophagus Mucosa	NEK4	0.05	0.03	lasso	8	0.02	2.4e-02	4.2	5.4	6.3e-08	0.85	0.15	0.78	FALSE
12	GTEx	Esophagus Muscularis	NEK4	0.06	0.00	lasso	3	0.02	2.8e-02	5.0	5.5	4.1e-08	0.83	0.14	0.72	FALSE
13	GTEx	Heart Atrial Appendage	GLYCTK	0.08	0.02	lasso	5	0.00	3.0e-01	4.6	5.3	1.2e-07	0.82	0.13	0.72	FALSE
14	GTEx	Heart Atrial Appendage	GLYCTK-AS1	0.06	-0.01	lasso	2	0.00	6.1e-01	4.6	5.3	1.1e-07	0.81	0.10	0.65	FALSE
15	GTEx	Muscle Skeletal	ITIH4-AS1	0.06	0.03	lasso	4	0.06	2.3e-06	-4.8	-5.3	1.2e-07	-0.82	0.12	0.88	FALSE
16	GTEx	Pituitary	SFMBT1	0.16	0.01	enet	9	0.02	1.2e-01	-5.2	-5.4	5.4e-08	-0.79	0.08	0.64	FALSE
17	GTEx	Small Intestine Terminal Ileum	RP5-966M1.6	0.14	0.03	lasso	7	0.00	2.5e-01	-5.2	-5.4	8.0e-08	-0.79	0.07	0.38	FALSE
18	GTEx	Whole Blood	ITIH4-AS1	0.33	0.24	lasso	7	0.25	9.7e-23	-4.7	-5.2	1.9e-07	-0.60	0.22	0.77	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	NEK4	0.04	0.05	blup	359	0.05	1.1e-06	5.0	5.2	1.7e-07	0.92	0.09	0.90	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	GNL3	0.15	0.23	enet	16	0.22	2.0e-28	5.0	5.2	2.1e-07	0.96	0.08	0.92	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	WDR82	0.03	0.02	enet	11	0.03	1.2e-04	4.1	-5.4	6.4e-08	-0.67	0.21	0.74	FALSE
22	YFS	Blood	GNL3	0.02	0.03	enet	11	0.03	2.9e-09	-4.7	5.5	3.7e-08	0.91	0.19	0.80	FALSE
23	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ITIH4	0.04	0.03	blup	53	0.03	7.4e-04	-4.7	-5.6	2.6e-08	-0.84	0.06	0.74	FALSE
24	The Cancer Genome Atlas	Glioblastoma Multiforme	ITIH4	0.10	0.02	blup	53	0.05	1.2e-02	-4.6	-5.3	9.9e-08	-0.72	0.03	0.42	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ITIH4	0.04	0.02	blup	53	0.03	3.0e-04	-5.3	-5.6	1.8e-08	-0.85	0.03	0.91	FALSE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ITIH4	0.14	0.08	lasso	3	0.10	7.0e-12	-4.9	-5.2	2.5e-07	-0.71	0.10	0.89	FALSE
27	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ITIH4	0.05	0.02	blup	53	0.02	1.1e-02	-4.7	-5.5	4.6e-08	-0.77	0.05	0.52	FALSE
28	The Cancer Genome Atlas	Rectum Adenocarcinoma	ITIH4	0.12	0.09	blup	53	0.06	1.4e-02	-5.3	-5.7	1.2e-08	-0.89	0.02	0.66	TRUE