Hub : Genes

WDR82

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.0490 0.0260 1.4e-03 0.021 NA 0.000 NA 0.017 9.4e-03 NA 3.2e-01 NA 1.8e-02
2 NTR Blood 0.0227 0.0095 3.9e-08 0.030 0.026 0.020 0.024 0.016 5.9e-10 4.9e-09 4.4e-07 2.0e-08 3.4e-06
3 ROSMAP Brain Pre-frontal Cortex 0.0317 0.0193 1.2e-03 0.024 0.018 0.028 0.015 0.027 3.5e-04 2.2e-03 1.2e-04 4.4e-03 1.7e-04
4 TCGA Esophageal Carcinoma 0.3050 0.1300 5.4e-04 0.054 0.061 0.092 NA 0.091 8.2e-03 5.2e-03 7.3e-04 NA 7.9e-04
5 TCGA Brain Lower Grade Glioma 0.0499 0.0358 9.8e-03 0.026 0.006 0.007 NA 0.014 5.7e-04 5.6e-02 4.5e-02 NA 8.0e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 7.7 12.1 19.4 -4.1 -4.4 -4.2 -2.4 -0.9
Bipolar Disorder or Schizophrenia 9.6 23.4 39.7 -6.0 -6.3 -5.9 -2.4 -1.2
Depressed Affect (Nagel 2018) 1.4 3.0 5.4 -2.3 -1.7 -1.9 0.1 1.8
Depression (Nagel 2018) 3.9 5.8 9.4 -2.7 -2.7 -3.1 -2.0 -1.2
Intelligence (Savage-Jansen 2018) 7.0 21.5 41.3 6.4 6.2 4.9 1.8 0.3
Neuroticism (Nagel 2018) 6.3 14.8 29.7 -4.7 -4.2 -5.5 -2.2 0.6
Schizophrenia (2018) 5.4 11.2 20.9 -4.4 -4.6 -3.8 -1.1 -0.9
Schizophrenia vs Biploar Disorder 0.3 0.5 1.5 0.1 0.7 -0.0 1.2 0.5
Worry (Nagel 2018) 14.2 29.9 58.0 -6.3 -6.2 -7.6 -3.5 -1.1
Alzheimer’s Disease (in mother) 0.5 0.6 1.1 -1.1 -1.0 -0.3 0.2 0.9
Alzheimer’s Disease (in father) 0.8 0.8 2.3 -1.1 -0.3 -0.4 1.5 0.7
Alzheimer’s Disease (including proxy) 0.9 1.2 2.0 -1.4 -0.9 -0.5 1.1 1.4
Crohns Disease (2017) 0.5 1.2 4.2 -0.8 -0.6 -2.1 -0.6 0.4
Irritable Bowel Disease (IBD) 1.2 2.9 8.7 -1.5 -1.5 -3.0 -1.0 0.4
Ulcerative Colitis (UC) 1.0 1.8 5.0 -1.3 -1.4 -2.2 -0.6 0.4
Major Depression (MDD) 3.2 3.9 9.5 -3.1 -1.9 -2.5 0.1 0.0
Reaction Time 0.2 0.4 1.4 -0.7 -0.2 -0.1 1.2 0.3
Verbal and Numeric Reasoning (VNR) 6.9 16.6 29.5 5.1 5.4 4.5 2.2 1.5
Breast Cancer 0.6 1.4 3.0 1.7 1.5 1.1 0.2 0.9
Ovarian Cancer 1.1 1.5 2.7 -0.2 -1.0 -1.3 -1.7 -1.4
Prostate Cancer 0.6 0.9 2.5 -1.2 -1.6 -0.3 -0.6 -0.1
Age at First Birth 3.0 4.3 6.6 2.5 2.6 1.9 1.9 -1.2
Bipolar Disorder (2011) 12.4 12.0 24.0 -4.9 -4.5 -4.0 -0.6 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 1.9 1.3 0.2 -0.2 -1.4 -0.1
Coronary Artery Disease (CAD) 0.2 0.3 0.6 0.8 0.0 0.8 0.0 -0.4
Crohns Disease (2012) 0.6 1.0 3.5 -0.4 -0.6 -1.9 -0.9 0.0
Mean Putamen Volume 0.5 0.6 1.4 -0.9 -0.3 -1.2 -0.4 -0.7
Fasting Glucose 1.0 1.1 4.3 0.7 -0.3 -0.0 -0.9 -2.1
HbA1C 0.0 0.1 0.2 -0.1 0.1 0.1 0.5 0.1
HDL Cholesterol 3.0 5.1 14.3 -0.3 1.2 0.8 3.0 3.8
LDL Cholesterol 3.3 5.2 10.9 3.3 2.2 2.1 -0.9 -2.2
Lupus 0.2 0.3 0.5 0.7 0.3 0.5 -0.7 -0.7
Neuroticism (2016) 4.7 6.8 18.7 -2.3 -2.6 -4.3 -1.6 0.8
Primary Biliary Cirrhosis 1.8 2.6 4.9 2.0 2.2 1.8 0.0 -0.8
Rheumatoid Arthritis 2.3 3.2 6.1 1.6 2.5 1.6 2.1 -0.3
Schizophrenia (2014) 7.2 16.0 28.9 -5.0 -5.4 -4.5 -1.8 -1.5
Triglycerides 1.9 3.1 7.1 -0.3 -1.6 -0.7 -2.7 -2.2
Type 2 Diabetes (T2D) (2012) 3.1 3.6 6.8 -1.2 -1.5 -2.6 -2.1 -1.7
Ulcerative Colitis 2.7 4.0 8.8 -2.3 -2.3 -3.0 -0.6 0.5
Blood Eosinophil Count 1.4 10.9 22.0 4.2 3.3 4.7 0.6 -1.9
Blood Platelet Count 2.4 27.9 51.1 5.9 7.2 6.6 3.1 0.1
Blood Red Count 5.0 48.6 104.0 -8.1 -10.2 -6.9 -4.7 -2.1
Blood White Count 0.6 4.3 10.3 1.1 -1.2 1.4 -2.5 -3.2
Heel T-Score 0.2 1.4 2.3 1.0 0.6 1.5 -0.9 -1.5
BMI 3.1 18.3 37.7 6.1 3.6 4.7 1.8 3.9
Height 3.0 56.9 125.4 -11.2 -7.5 -9.2 -0.5 4.1
Waist Hip Ratio (WHR) 16.1 72.3 95.5 -6.6 -9.8 -8.6 -9.2 -8.0
Systolic Blood Pressure 1.8 9.3 19.4 4.3 4.4 2.2 1.8 -0.5
Smoking Status 4.7 11.3 26.1 5.1 3.6 4.0 -0.7 -1.0
Allergy or Eczema 0.4 1.0 3.2 -1.8 -1.2 0.2 0.2 0.6
Cardiovascular Disease 1.0 3.4 8.8 3.0 2.5 1.2 0.4 0.4
Hypothyroidism (self reported) 1.6 3.6 9.5 0.7 1.1 3.1 2.1 1.5
Respiratory disease 0.5 1.2 2.2 -1.5 -1.2 -0.8 0.8 0.9
Type 2 Diabetes (T2D) (2018) 1.4 2.6 6.1 1.7 1.8 2.5 0.7 0.4
Lung FEV1/FVC ratio 1.8 9.0 22.9 4.8 3.6 2.6 1.7 0.0
Lung FVC 1.6 7.9 15.3 3.9 3.2 2.2 0.8 -3.0
Neuroticism 6.0 14.6 24.7 -4.7 -4.7 -5.0 -1.7 1.2
Chronotype (morning person) 0.8 2.0 5.1 2.3 -0.5 -0.6 -1.9 -0.5
Hair Pigment 0.0 1.3 2.4 -0.0 1.2 1.1 1.1 1.5
Tanning 1.0 11.9 19.6 4.3 4.4 3.8 1.8 1.7
Hand grip strength (left) 1.2 3.3 7.6 -2.7 -1.8 -1.3 0.1 2.0
Number of treatments/medications taken 0.9 1.6 5.2 2.3 0.4 0.3 -1.4 -0.5
Average weekly spirits intake 2.5 3.1 4.7 1.8 2.2 1.7 1.1 1.9
Sensitivity / hurt feelings 0.8 1.4 2.9 -1.3 -1.0 -1.7 -1.2 0.1
Frequency of depressed mood in last 2 weeks 5.2 7.3 14.3 -2.2 -2.7 -3.8 -2.9 -1.2
Hearing difficulty/problems: Yes 1.7 2.5 8.1 -0.2 -0.2 -1.0 -1.9 -2.9
Relative age of first facial hair 0.2 0.4 1.7 0.2 1.3 -0.5 0.4 0.1
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 3.5 -0.5 -1.1 -0.6 -0.8 -1.9
Ever used hormone-replacement therapy (HRT) 2.9 3.7 9.8 0.8 -1.4 -1.7 -3.1 -1.8
Ever had hysterectomy (womb removed) 1.8 2.0 5.5 0.8 -0.8 0.0 -2.3 -1.7
Systolic blood pressure, automated reading 2.6 7.5 14.2 3.6 3.8 2.2 2.4 0.4
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 1.6 1.1 0.1 -0.7 -1.3 -1.2
Angina 0.3 0.3 0.7 0.8 0.3 0.7 0.1 -0.6
Medication for hormone replacement therapy 1.2 1.4 3.0 0.6 -0.8 -0.8 -1.7 -1.5
Vitamin and mineral supplements 0.6 0.9 1.5 -1.2 -1.1 -1.2 -0.3 -0.2
Supplements: Zinc 0.8 0.8 2.2 0.3 -0.5 -0.8 -1.0 -1.5
Medication: Co-codamol 1.1 1.2 5.4 0.1 -0.5 -0.1 -0.7 -2.3
Medication: Metformin 0.6 0.9 1.1 1.0 1.1 0.8 0.8 0.9
Diabetes (father) 0.1 0.1 0.3 0.3 -0.3 -0.0 -0.5 -0.5
Diabetes (mother) 0.7 0.9 2.4 -1.5 -0.8 -0.3 -1.1 -0.4
Severe depression (siblings) 2.3 2.5 5.1 -0.9 -1.1 -2.3 -1.9 -1.5
Pack years adult smoking proportion 2.0 3.1 5.1 -1.2 -2.2 -1.8 -1.7 -1.7
Impedance of leg (right) 3.0 14.6 28.9 -5.4 -4.0 -3.5 -2.2 -3.4
Leg fat-free mass (left) 0.4 2.0 8.7 1.1 0.1 -0.2 0.3 2.9
Trunk fat percentage 0.4 1.6 4.8 -1.1 -2.2 -0.4 -0.3 1.4
Hand grip strength (right) 1.9 5.2 14.4 -2.7 -0.7 -0.2 1.9 3.8
Townsend deprivation index at recruitment 0.3 0.5 0.9 0.9 0.7 0.2 -0.5 -0.9
Current tobacco smoking 1.3 2.1 3.6 1.9 1.1 1.6 -0.8 -1.5
Average weekly fortified wine intake 1.1 1.3 2.9 -1.7 -0.5 -0.3 1.3 1.4
Maternal smoking around birth 0.8 1.1 3.0 -0.4 -1.1 -1.0 -0.5 -1.7
Fed-up feelings 0.9 1.6 4.3 -0.9 -1.1 -2.1 -1.3 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.8 3.7 8.4 -1.1 -1.0 -2.9 -2.4 -1.4
Relative age voice broke 2.3 3.5 9.7 2.3 3.1 1.2 0.8 -0.4
Taking other prescription medications 1.5 2.2 4.2 0.3 -1.4 -1.3 -2.1 -1.9
Age when periods started (menarche) 7.7 18.4 27.4 2.7 5.2 4.9 5.0 2.8
Bilateral oophorectomy (both ovaries removed) 1.8 2.1 5.4 0.8 -1.3 -1.0 -2.3 -1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.5 4.9 2.2 0.2 0.8 -1.0 -1.1
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.4 -0.4 -0.4 -1.2 -0.9 -0.2
Qualifications: CSEs or equivalent 1.0 1.3 2.7 -1.6 -0.9 -0.5 0.6 1.7
Serious illness, injury or assault to yourself 3.2 3.9 6.6 -0.7 -2.1 -1.4 -2.6 -2.5
High blood pressure 1.5 4.0 8.0 2.2 2.8 1.2 2.0 1.4
Hayfever, allergic rhinitis or eczema 1.1 2.3 4.8 -2.2 -2.1 -1.2 -0.9 0.2
Multivitamins +/- minerals 2.0 2.6 4.9 1.9 1.7 2.2 1.1 -0.4
Stomach or abdominal pain in last month 5.1 6.3 9.1 -1.9 -2.8 -2.7 -3.0 -1.8
Supplements: Glucosamine 0.5 0.6 1.0 0.9 0.3 1.0 -0.8 -0.9
Diverticular disease/diverticulitis (self-reported) 2.2 2.6 10.7 0.1 -0.7 0.1 -1.3 -3.3
Medication: Atenolol 0.8 1.0 1.7 1.3 0.8 1.1 1.2 -0.1
Medication: Levothyroxine sodium 2.0 3.4 7.6 1.0 1.4 2.8 2.4 0.9
Sitting height 1.8 12.8 24.0 -4.9 -3.5 -4.6 -0.0 2.7
Chronic bronchitis/emphysema (father) 0.5 0.5 1.7 -0.8 0.5 0.2 1.3 0.0
High blood pressure (mother) 2.8 3.9 8.3 -0.5 -1.7 -2.9 -2.8 -0.5
Body mass index (BMI) 1.8 7.8 22.4 4.7 2.1 2.9 0.7 1.7
Impedance of leg (left) 3.6 17.6 33.6 -5.8 -4.3 -4.0 -2.7 -3.6
Leg predicted mass (left) 0.4 2.0 8.8 1.1 0.1 -0.2 0.3 3.0
Trunk fat mass 0.4 1.6 3.9 -0.5 -1.9 -0.6 -0.2 2.0
Waist circumference 1.0 3.7 7.8 0.2 -2.8 -1.6 -2.6 -1.0
Number of incorrect matches in round 2.6 4.4 7.4 -2.7 -2.4 -1.6 1.4 2.1
Past tobacco smoking 4.2 7.6 13.9 -3.5 -3.4 -3.7 -0.5 -0.3
Alcohol usually taken with meals 1.2 2.0 4.0 -1.4 -1.5 -1.0 -2.0 -0.9
Nervous feelings 7.9 14.8 29.2 -4.8 -4.0 -5.4 -2.3 -0.3
Frequency of tenseness / restlessness in last 2 weeks 6.8 10.6 26.1 -2.8 -3.4 -5.1 -2.7 -0.3
Hearing difficulty/problems with background noise 2.5 4.0 6.5 -1.2 -2.0 -2.5 -2.2 -1.8
Hair/balding pattern: Pattern 2 0.4 0.5 1.8 0.2 0.3 0.8 0.2 1.4
Had menopause 0.4 0.5 1.1 1.0 1.0 0.4 0.3 -0.5
Had other major operations 0.6 0.8 2.3 1.0 -0.5 -0.4 -1.5 -0.5
Forced vital capacity (FVC) 0.8 3.1 8.7 -1.7 -1.6 -2.9 -1.0 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 4.0 2.0 0.1 1.7 -0.7 -1.3
Ever unenthusiastic/disinterested for a whole week 1.4 1.8 2.5 -0.1 -1.6 -1.5 -1.6 -1.2
Qualifications: None of the above 0.5 1.2 2.9 -0.0 1.0 0.7 1.7 1.2
Financial difficulties in last 2 years 1.5 2.0 4.9 -0.2 -1.0 -0.3 -2.2 -2.0
Mouth/teeth dental problems 0.3 0.5 1.3 1.2 0.5 0.4 0.4 0.7
Heart attack 2.0 2.6 7.8 1.4 1.1 2.8 1.3 -0.2
Allergy 1.9 4.4 9.4 3.1 3.0 1.5 0.7 -1.1
Pain all over the body in last month 1.7 1.8 4.0 -1.0 -2.0 -1.8 -0.9 -0.1
Diabetes (self-reported) 1.6 2.5 3.8 1.9 2.0 1.9 1.2 -0.1
Hayfever/allergic rhinitis (self-reported) 0.7 1.0 1.8 -1.3 -1.2 -1.1 -0.4 0.5
Medication: Ramipril 0.4 0.5 1.1 0.5 1.0 1.1 0.0 -0.3
Medication: Simvastatin 0.6 0.9 3.5 0.4 0.4 -0.0 0.9 1.9
Fluid intelligence score 4.0 8.3 14.3 3.7 3.8 3.4 1.5 0.4
Illnesses of siblings 0.2 0.2 0.9 0.2 -0.4 0.9 0.4 -0.0
Neuroticism score 4.1 8.6 19.5 -3.1 -3.0 -4.4 -2.1 0.6
Weight 0.3 1.5 6.0 1.2 -0.3 -0.1 0.0 2.4
Impedance of arm (right) 4.5 21.1 57.0 -7.5 -5.2 -4.1 -1.4 -1.6
Arm fat percentage (right) 0.4 1.4 2.5 1.6 -0.3 1.4 0.2 1.6
Trunk fat-free mass 0.2 1.4 4.5 1.2 0.4 -0.9 -0.1 2.1
Hip circumference 1.1 4.8 7.9 2.6 1.5 2.2 1.6 2.8
Time employed in main current job 0.4 0.4 1.0 0.7 0.5 0.0 -1.0 -0.7
Alcohol intake versus 10 years previously 2.8 4.2 8.2 1.5 2.9 2.5 2.0 0.6
Father’s age at death 0.3 0.4 1.1 -1.1 -0.7 -0.4 0.4 0.1
Worrier / anxious feelings 7.9 14.9 33.3 -3.7 -4.4 -5.8 -2.5 -1.5
Frequency of tiredness / lethargy in last 2 weeks 3.9 6.4 13.6 -0.8 -2.1 -3.3 -3.7 -1.5
Falls in the last year 1.2 1.7 4.6 0.6 -0.4 -1.3 -2.1 -1.3
Hair/balding pattern: Pattern 3 0.3 0.5 0.7 0.6 0.5 0.6 -0.7 -0.8
Number of live births 0.2 0.3 1.2 0.3 0.4 -0.1 -0.0 -1.1
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 3.8 -0.2 -0.5 -1.9 -0.7 -0.4
Pulse rate 6.0 10.1 16.8 -3.5 -4.1 -3.3 -2.8 -1.6
Happiness 4.5 5.4 10.2 -2.7 -2.3 -3.2 -0.7 2.0
Noisy workplace 1.3 1.7 2.6 0.7 1.6 1.6 1.5 0.6
Qualifications: A levels/AS levels or equivalent 0.4 0.8 1.5 1.2 1.1 0.9 0.8 0.1
Serious illness, injury or assault of a close relative in last 2 years 2.6 3.0 5.9 -0.9 -1.3 -2.4 -2.2 -1.3
Mouth/teeth dental problems: Dentures 0.2 0.3 0.6 0.4 0.6 0.7 0.8 -0.1
Asthma 0.3 0.6 2.4 -0.6 -1.5 -0.3 -0.4 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.3 0.8 -0.2 -0.7 -1.1 1.5
Medication: Cholesterol lowering 1.5 2.3 4.1 2.0 1.6 1.4 0.9 1.4
Depression (self-reported) 3.9 4.7 12.0 -2.1 -1.8 -3.5 -1.9 -0.6
Medication: Lansoprazole 2.0 2.3 5.1 0.0 -1.2 -2.0 -2.3 -0.9
Prospective memory result 5.7 7.0 13.0 -3.6 -3.2 -2.9 -2.0 -0.2
Lung cancer (father) 0.1 0.2 0.4 0.1 -0.5 0.6 0.4 0.3
Illnesses of mother 2.5 3.1 8.6 1.5 1.7 2.9 1.2 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 4.5 -0.0 -0.7 -2.1 -1.1 -0.8
Pulse wave Arterial Stiffness index 0.8 1.0 3.2 1.8 0.9 0.6 0.0 -0.7
Impedance of arm (left) 4.8 22.1 59.9 -7.7 -5.4 -4.3 -1.2 -1.1
Arm fat mass (right) 0.3 1.4 3.3 1.7 -0.2 0.9 0.1 1.8
Trunk predicted mass 0.2 1.4 4.5 1.2 0.5 -0.9 -0.0 2.1
Standing height 2.7 26.3 54.0 -7.3 -5.3 -6.6 -1.8 1.5
Length of working week for main job 0.2 0.3 0.5 -0.2 0.1 0.7 0.4 0.7
Exposure to tobacco smoke at home 0.5 0.6 2.0 -0.4 -0.2 -0.4 0.8 1.4
Breastfed as a baby 3.3 4.1 8.7 0.5 1.9 2.3 3.0 1.5
Tense / ‘highly strung’ 6.5 10.7 27.7 -3.2 -3.2 -5.3 -2.3 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 4.6 7.0 14.8 -2.9 -2.9 -3.8 -1.5 0.8
Hair/balding pattern: Pattern 4 1.1 2.7 4.8 2.2 2.0 1.3 1.6 0.8
Birth weight of first child 0.2 0.4 1.4 -1.2 -0.6 -0.2 0.1 0.4
Peak expiratory flow (PEF) 0.1 0.3 0.6 -0.1 0.2 -0.8 0.4 0.8
Pulse wave reflection index 1.6 1.9 5.3 2.3 1.7 0.5 0.5 1.0
Ever highly irritable/argumentative for 2 days 3.1 3.7 10.5 3.2 2.0 1.6 -0.3 -1.0
Loud music exposure frequency 0.6 0.6 1.3 -1.1 0.4 -1.1 0.4 0.4
Qualifications: O levels/GCSEs or equivalent 0.5 0.7 1.4 -1.0 -0.9 -0.6 0.2 1.2
Mouth/teeth dental problems: Bleeding gums 3.0 3.9 6.4 -2.5 -1.8 -2.4 -1.7 -1.2
Blood clot in the leg (DVT) 1.8 2.3 4.6 -1.7 -2.1 -1.1 -1.5 -0.4
Medication: Paracetamol 3.2 5.4 9.0 -2.0 -2.4 -2.3 -3.0 -1.7
Headache pain in last month 5.7 9.8 17.7 -4.1 -4.2 -3.0 -2.3 0.0
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 3.3 -1.8 -1.7 -1.6 -1.3 -1.1
Glaucoma (self-reported) 2.9 3.4 5.5 -1.2 -2.1 -2.4 -1.5 -1.8
Gout (self-reported) 2.7 3.7 9.6 -1.5 -2.2 -3.1 -1.5 -0.4
Hypothyroidism/myxoedema (self-reported) 1.6 3.1 6.5 0.9 1.1 2.5 2.2 1.4
Medication: Amlodipine 1.1 1.5 3.3 1.8 1.8 -0.4 0.3 -0.9
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.7 -0.3 -1.3 -0.4 -0.8 -0.3
Birth weight 0.5 1.2 4.1 -0.9 -0.6 -2.0 -0.5 0.5
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.7 -1.6 -0.6 -1.3 -0.0 -0.0
High blood pressure (siblings) 0.3 0.4 0.7 0.2 0.7 -0.8 -0.6 -0.7
Forced vital capacity (FVC), Best measure 1.1 3.9 11.0 -1.7 -1.8 -3.3 -1.4 -0.6
Body fat percentage 0.2 0.7 1.7 0.3 -1.3 0.4 -0.2 1.2
Leg fat percentage (right) 0.6 2.3 7.1 2.7 0.4 1.9 0.2 0.7
Arm fat-free mass (right) 0.3 1.6 5.6 1.4 0.5 -0.7 -0.1 2.4
Exposure to tobacco smoke outside home 0.2 0.3 0.6 -0.5 -0.1 -0.8 0.2 0.8
Comparative body size at age 10 1.2 3.4 6.9 2.6 2.0 1.9 -1.1 -0.9
Number of full brothers 1.1 1.4 3.2 1.8 0.9 1.7 0.1 -0.0
Worry too long after embarrassment 4.2 7.0 15.5 0.1 -1.6 -3.5 -3.9 -2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 5.8 7.5 14.1 -2.2 -3.1 -3.8 -2.7 -1.2
Wheeze or whistling in the chest in last year 3.5 6.2 12.0 -2.2 -3.5 -3.2 -1.9 -0.2
Number of children fathered 1.0 1.1 3.4 1.4 0.0 1.9 -0.0 0.2
Reason for reducing amount of alcohol drunk: Health precaution 1.7 2.0 6.1 -2.5 -1.5 -1.0 -0.1 0.8
Age at first live birth 0.8 1.4 2.9 0.5 1.2 1.5 1.7 0.4
Pulse wave peak to peak time 1.5 1.7 5.2 -2.3 -1.3 -0.9 -0.1 1.0
Health satisfaction 1.3 1.7 4.7 0.3 -0.5 -2.2 -1.7 -0.6
Shortness of breath walking on level ground 0.3 0.4 1.1 -0.1 -0.6 -0.8 -0.2 1.0
Qualifications: College or University degree 1.8 5.8 8.6 -2.0 -2.9 -2.9 -2.4 -1.5
Eye problems/disorders: None of the above 2.3 2.6 5.8 2.0 2.4 1.7 0.7 -0.2
Mouth/teeth dental problems: Loose teeth 0.7 0.9 2.3 -1.1 -0.7 -1.5 -0.3 0.4
Emphysema/chronic bronchitis 0.6 0.6 1.3 -0.8 0.7 -0.9 1.2 0.1
Medication for pain relief, constipation, heartburn 3.0 5.1 10.3 0.8 2.1 3.2 3.2 0.6
Neck or shoulder pain in last month 0.6 0.8 2.0 0.2 -0.4 -0.7 -1.2 -1.4
Medication: Blood pressure 1.6 2.8 4.4 1.3 2.1 1.7 2.0 1.1
Angina (self-reported) 0.3 0.4 1.0 1.0 0.2 0.8 0.0 -0.7
Migraine (self-reported) 1.9 2.4 7.8 -2.8 -1.5 -0.5 0.8 1.0
Medication: Ibuprofen 0.9 1.1 2.4 1.5 0.7 0.2 -0.6 1.5
Medication: Allopurinol 1.3 1.8 4.3 -0.9 -1.5 -2.1 -1.2 -0.4
Medication: Omeprazole 3.2 3.8 9.7 0.8 -1.1 -1.5 -3.1 -2.3
Medication: Seretide 50 evohaler 0.1 0.1 0.1 0.3 -0.3 0.1 0.3 0.3
Mean time to correctly identify matches 0.5 1.0 3.9 -0.1 0.8 0.6 2.0 0.5
Heart disease (mother) 0.2 0.3 0.9 0.9 0.4 -0.3 -0.2 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.5 3.0 1.7 1.1 1.2 1.2 0.6
Whole body fat mass 0.2 0.9 2.6 0.7 -1.1 0.2 -0.2 1.6
Leg fat mass (right) 0.5 1.8 5.2 2.3 0.1 1.1 -0.0 1.6
Arm predicted mass (right) 0.3 1.5 5.0 1.4 0.5 -0.6 0.0 2.2
Pulse rate, automated reading 3.6 11.5 17.1 -2.5 -4.1 -2.7 -3.9 -3.5
Alcohol intake frequency. 0.7 1.6 3.5 -1.3 -1.9 -1.3 -0.7 -0.8
Comparative height size at age 10 3.0 16.8 30.2 -5.5 -5.1 -4.7 -2.3 -0.3
Number of full sisters 0.5 0.6 1.0 0.4 0.9 1.0 1.0 -0.3
Suffer from ‘nerves’ 6.4 10.1 21.0 -4.0 -3.2 -4.6 -1.4 1.2
Overall health rating 1.9 4.2 6.2 -0.1 -1.9 -2.4 -2.5 -2.3
Chest pain or discomfort 2.4 3.4 6.4 -2.4 -2.1 -2.5 -0.6 -0.2
Had major operations 1.4 1.6 3.4 1.1 1.8 1.3 1.1 -0.9
Age at last live birth 0.3 0.4 0.8 -0.2 0.5 0.8 0.9 -0.4
Family relationship satisfaction 4.3 5.2 8.3 -2.9 -2.4 -2.6 -2.3 0.3
Leg pain on walking 0.4 0.5 1.2 1.1 0.6 0.7 0.3 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.6 -0.5 -0.7 0.7 -0.3 -0.6
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.2 0.3 0.4 -0.0 1.0 1.5
Illness, injury, bereavement, stress in last 2 years 4.9 5.9 11.3 1.8 3.0 2.1 3.4 1.4
Medication: Aspirin 0.4 0.5 1.5 0.3 -0.4 -0.8 -0.1 1.2
Supplements: Vitamin C 0.1 0.2 0.4 0.7 -0.2 -0.4 -0.4 -0.2
Knee pain experienced in last month 0.4 0.6 1.5 1.2 0.4 0.7 -0.7 -0.3
Hypertension (Self-reported) 1.6 4.5 9.0 2.5 3.0 1.3 2.1 1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.3 -0.2 -0.2 -0.2 -0.6 -0.2
Illnesses of father: Heart disease 0.4 0.5 1.8 1.3 0.7 -0.4 0.2 -0.2
Illnesses of siblings: Diabetes 0.8 1.0 3.0 0.6 1.0 1.7 0.4 -0.7
Smoking status: Previous 1.9 2.8 5.6 2.4 2.0 2.1 -0.4 0.5
Forced expiratory volume in 1-second (FEV1), predicted 2.1 4.4 11.8 -3.4 -1.9 -2.3 -0.0 1.1
Whole body fat-free mass 0.3 1.5 5.8 1.1 0.3 -0.8 -0.0 2.4
Leg fat-free mass (right) 0.3 1.8 7.7 0.8 -0.1 -0.6 -0.0 2.8
Arm fat percentage (left) 0.3 1.4 3.3 1.3 -0.5 1.2 0.2 1.8
Average weekly red wine intake 0.6 0.9 3.8 -0.2 -0.2 0.8 -0.1 1.9
Handedness (chirality/laterality): Left-handed 0.7 0.9 2.7 -0.6 -0.1 -1.6 -0.9 0.6
Mood swings 2.5 4.5 8.3 -2.6 -2.0 -2.9 -0.7 1.7
Loneliness, isolation 1.1 1.5 3.5 -1.9 -1.2 -1.2 -0.1 0.9
Long-standing illness, disability or infirmity 2.0 3.0 5.8 1.8 -0.6 0.0 -2.4 -2.4
Ever had bowel cancer screening 0.4 0.5 1.4 0.4 0.3 -1.2 -0.8 -0.4
Diabetes diagnosed by doctor 2.0 3.2 6.4 2.5 2.2 1.9 1.1 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 0.0 0.0 0.4 -0.4 -0.5
Friendships satisfaction 3.2 4.0 8.5 -2.9 -1.8 -2.2 -0.5 1.8
Qualifications: nursing, teaching 0.5 0.8 2.4 1.0 -0.2 -0.2 -1.5 -0.7
Commuting to job workplace: Walk 1.3 1.4 3.7 0.4 0.5 1.7 -0.4 -1.9
Eye problems/disorders: Cataract 1.5 1.8 4.1 -2.0 -2.0 -0.7 -0.6 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.3 -0.1 -0.2 0.1 -0.6 -0.1
Medication for cholesterol 2.0 3.0 7.2 -2.2 -0.6 0.1 1.5 2.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.3 4.2 -2.0 -1.6 -1.7 -0.7 1.2
Back pain experienced in last month 1.2 1.8 3.6 1.6 1.9 0.9 -0.1 -1.4
Mineral and other dietary supplements 1.4 1.8 4.5 -2.1 -1.4 -1.3 0.8 0.6
Breast cancer (self-reported) 0.1 0.1 0.2 0.1 -0.1 -0.5 -0.1 -0.2
Asthma (self-reported) 0.5 0.9 3.2 -0.9 -1.8 -0.6 -0.5 -0.1
Osteoporosis (self-reported) 0.4 0.6 1.8 0.3 0.2 0.9 0.0 -1.3
Osteoarthritis (self-reported) 0.3 0.4 1.1 0.6 -0.5 -0.3 -1.0 0.2
Medication: Aspirin 0.3 0.4 1.4 0.4 -0.3 -0.6 0.2 1.2
Medication: Gliclazide 0.1 0.1 0.2 -0.3 -0.3 -0.3 -0.4 0.0
Illnesses of father: None of the above (group 1) 0.7 0.8 2.6 -0.2 -1.2 -0.2 -1.6 -0.2
Smoking status: Current 1.6 2.6 4.6 2.1 1.4 2.1 -0.5 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 2.9 1.4 0.8 -0.3 -0.3 -1.7
Whole body water mass 0.3 1.6 5.9 1.2 0.3 -0.8 -0.2 2.4
Leg predicted mass (right) 0.3 1.7 7.2 0.9 -0.1 -0.6 -0.1 2.7
Arm fat mass (left) 0.4 1.7 4.6 1.8 -0.3 0.8 0.1 2.1
Number of self-reported non-cancer illnesses 0.2 0.3 0.5 0.3 -0.2 -0.7 -0.7 -0.7
Average weekly champagne plus white wine intake 3.6 5.0 9.7 2.7 3.1 2.4 1.2 0.8
Miserableness 0.4 0.6 1.7 0.6 0.7 -0.6 0.3 1.3
Guilty feelings 3.0 4.5 9.0 -2.9 -2.1 -3.0 -0.9 -0.1
Wears glasses or contact lenses 6.6 7.6 11.5 2.2 3.1 2.7 3.4 2.2
Ever taken oral contraceptive pill 0.3 0.4 0.9 0.9 0.4 0.1 -0.9 0.2
Hearing aid user 2.5 2.9 6.9 2.6 1.4 2.2 0.7 -0.4
Mother’s age at death 1.4 1.7 4.4 -1.2 0.6 1.0 2.1 1.1
Financial situation satisfaction 0.6 0.7 1.7 -0.6 0.3 -1.1 -1.3 -0.3
Tinnitus: Yes, now most or all of the time 2.1 2.4 7.2 -2.7 -1.8 -1.2 -0.0 0.3
Commuting to job workplace: Public transport 0.8 1.0 2.2 -0.7 -1.3 -0.3 -1.5 -0.6
Eye problems/disorders: Glaucoma 1.0 1.2 2.4 -1.0 -1.1 -1.5 -0.2 -1.2
Medication: Blood pressure 1.0 1.9 4.5 2.0 2.1 -0.1 0.5 -0.7
Pain type(s) experienced in last month: Hip pain 1.6 2.0 5.5 1.3 -1.2 -0.8 -2.3 -0.9
Supplements: Fish oil (including cod liver oil) 1.0 1.3 3.8 2.0 1.3 0.9 -0.2 -0.2
High cholesterol (Self-reported) 0.8 1.4 3.2 1.8 1.4 0.3 1.0 0.9
Medication: Bendroflumethiazide 1.5 2.3 6.3 2.0 2.5 0.3 1.1 -0.4
Medication: Paracetamol 1.4 2.2 4.5 -1.3 -1.3 -1.6 -2.1 -0.8
Medication: Lisinopril 0.6 0.8 1.4 0.8 0.7 1.2 1.0 0.6
Medication: Atorvastatin 1.1 1.4 2.8 1.7 1.6 0.3 0.3 -1.3
Illnesses of father: High blood pressure 1.7 2.1 7.3 0.3 1.7 0.5 2.7 0.1
Alcohol drinker status: Never 0.8 1.0 1.6 -0.9 -1.2 -1.3 -0.9 -0.2
Ever smoked 5.5 9.7 17.6 3.6 4.2 4.1 1.0 0.5
Basal metabolic rate 0.3 1.5 5.8 1.1 -0.0 -0.7 -0.2 2.4
Leg fat percentage (left) 0.5 2.0 6.3 2.5 0.3 1.7 0.0 0.8
Arm fat-free mass (left) 0.3 1.5 4.1 1.4 0.2 -0.9 -0.6 2.0
Number of operations (self-reported) 0.4 0.6 1.7 -0.0 -0.5 -0.6 -1.3 -0.9
Average weekly beer plus cider intake 1.2 1.8 5.6 -0.4 0.0 1.2 2.4 1.3
Irritability 0.9 1.5 6.2 0.9 0.6 -0.2 -0.1 2.5
Risk taking 2.6 3.8 9.5 -0.4 -2.2 -1.9 -3.1 -1.0
Ever had prostate specific antigen (PSA) test 0.7 0.8 3.4 0.0 0.1 -0.2 0.6 1.9
Fractured/broken bones in last 5 years 1.4 1.8 2.7 1.4 1.6 1.4 1.3 -0.7
Age started oral contraceptive pill 0.2 0.2 0.6 -0.7 -0.0 0.1 0.8 0.2
Diastolic blood pressure, automated reading 0.8 2.4 4.8 -1.0 -1.9 -2.2 -1.4 -1.0
Ever depressed for a whole week 0.8 0.9 1.9 -0.5 -1.4 -1.1 -1.0 -0.4
Unable to work because of sickness or disability 0.5 0.6 2.7 0.3 -0.5 -0.2 -0.1 -1.6
Commuting to job workplace: Cycle 2.5 3.0 5.4 1.2 1.8 2.3 2.0 0.7
Myopia 1.7 2.5 5.3 2.3 1.8 1.8 0.1 -0.7
Vascular/heart problems diagnosed by doctor 1.0 2.8 5.7 -2.0 -2.4 -1.4 -1.4 -0.8
Cholesterol lowering medication 0.3 0.4 0.9 0.8 -0.1 -1.0 -0.3 -0.4
Medication: Omeprazole (e.g. Zanprol) 3.6 4.3 11.2 0.4 -1.2 -2.0 -3.4 -2.2
Pain experienced in last month 1.0 1.6 4.2 -0.4 0.9 1.3 2.0 1.2
Supplements: Calcium 0.3 0.3 1.0 -0.2 0.0 -1.0 -0.7 -0.4
Basal cell carcinoma (self-reported) 5.5 6.5 10.6 -2.3 -3.3 -2.7 -2.8 -1.2
Heart attack/myocardial infarction (self-reported) 1.5 2.0 6.4 1.4 0.8 2.5 0.9 -0.5
Deep venous thrombosis (DVT) (self-reported) 1.9 2.5 4.9 -2.0 -2.2 -1.2 -1.4 -0.3
Heart disease (siblings) 0.3 0.4 1.7 -0.2 -0.4 -1.3 -0.3 0.2
Alcohol drinker status: Previous 1.1 1.2 2.1 0.6 -1.4 -1.3 -1.4 -0.4
Pack years of smoking 1.2 1.8 3.3 -1.1 -1.8 -1.5 -0.9 -1.1
Impedance of whole body 5.1 25.8 61.6 -7.8 -5.7 -4.9 -2.3 -2.4
Leg fat mass (left) 0.4 1.6 4.7 2.2 0.0 1.0 -0.1 1.6
Arm predicted mass (left) 0.3 1.5 3.9 1.6 0.4 -0.8 -0.5 2.0