Best TWAS P=6.34e-13 · Best GWAS P=6.34e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SLC2A4 | 0.08 | 0.06 | lasso | 2 | 0.08 | 1.2e-09 | -3.9 | 5.2 | 1.7e-07 | 0.04 | 0.88 | 0.07 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | TNFSF12 | 0.25 | 0.22 | lasso | 8 | 0.20 | 7.4e-15 | 5.5 | 5.6 | 1.6e-08 | 0.14 | 0.99 | 0.01 | FALSE |
| 3 | GTEx | Colon Transverse | LSMD1 | 0.28 | 0.12 | lasso | 5 | 0.19 | 3.3e-09 | 7.2 | 6.7 | 1.7e-11 | 0.89 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Heart Left Ventricle | CHRNB1 | 0.16 | 0.03 | lasso | 4 | 0.05 | 9.6e-04 | 3.5 | -5.7 | 1.3e-08 | -0.36 | 0.04 | 0.71 | FALSE |
| 5 | METSIM | Adipose | SENP3 | 0.06 | 0.03 | lasso | 3 | 0.02 | 4.9e-04 | 5.5 | -6.3 | 3.6e-10 | -0.11 | 0.48 | 0.03 | FALSE |
| 6 | NTR | Blood | TNFSF12 | 0.06 | 0.07 | bslmm | 462 | 0.07 | 9.4e-23 | 5.7 | 5.9 | 3.2e-09 | 0.11 | 0.98 | 0.02 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | KDM6B | 0.07 | 0.05 | lasso | 4 | 0.04 | 2.7e-06 | 7.2 | -6.5 | 7.5e-11 | -0.95 | 0.00 | 1.00 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | SENP3 | 0.07 | 0.06 | lasso | 4 | 0.05 | 1.5e-07 | 5.3 | -5.4 | 6.2e-08 | -0.04 | 1.00 | 0.00 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | FGF11 | 0.08 | 0.04 | blup | 454 | 0.04 | 1.2e-05 | 3.5 | -5.3 | 1.3e-07 | -0.17 | 0.99 | 0.00 | FALSE |
| 10 | YFS | Blood | CYB5D1 | 0.28 | 0.19 | bslmm | 488 | 0.24 | 5.9e-79 | 4.5 | -5.4 | 5.7e-08 | -0.73 | 1.00 | 0.00 | FALSE |
| 11 | The Cancer Genome Atlas | Colon Adenocarcinoma | CYB5D1 | 0.14 | 0.12 | lasso | 1 | 0.10 | 1.7e-06 | 7.2 | -7.2 | 6.3e-13 | -1.00 | 0.00 | 1.00 | TRUE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | TNFSF12-TNFSF13 | 0.07 | 0.05 | lasso | 3 | 0.02 | 1.9e-02 | 5.5 | 5.6 | 2.1e-08 | 0.11 | 0.01 | 0.91 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TNFSF12 | 0.04 | 0.01 | enet | 9 | 0.01 | 4.3e-02 | 5.5 | -6.4 | 1.2e-10 | -0.08 | 0.01 | 0.85 | TRUE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SLC2A4 | 0.09 | 0.04 | lasso | 4 | 0.06 | 7.2e-08 | -4.8 | 5.5 | 3.0e-08 | 0.05 | 0.00 | 0.99 | TRUE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SHBG | 0.04 | 0.01 | blup | 60 | 0.03 | 5.4e-04 | 4.6 | 6.4 | 1.7e-10 | 0.10 | 0.01 | 0.59 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TNFSF12-TNFSF13 | 0.03 | 0.00 | lasso | 4 | 0.01 | 2.9e-02 | 5.5 | 5.9 | 4.4e-09 | 0.13 | 0.01 | 0.56 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | SHBG | 0.04 | 0.00 | blup | 59 | 0.02 | 4.4e-03 | 5.8 | 5.4 | 7.1e-08 | 0.10 | 0.01 | 0.78 | FALSE |