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chr17:45,921,906-47,718,188

Best TWAS P=1.87e-23 · Best GWAS P=2.23e-25 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SNF8	0.08	0.07	lasso	5	0.08	9.3e-10	3.48	-5.3	1.0e-07	-0.61	0.97	0.03	TRUE
2	CommonMind	Brain Pre-frontal Cortex	TTLL6	0.23	0.12	bslmm	418	0.15	1.7e-17	2.40	-5.5	4.0e-08	-0.20	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	UBE2Z	0.05	0.08	lasso	2	0.08	9.8e-10	9.89	-10.0	1.9e-23	-0.92	0.11	0.89	TRUE
4	GTEx	Cells EBV-transformed lymphocytes	UBE2Z	0.16	0.01	enet	25	0.10	3.5e-04	9.85	5.5	2.9e-08	0.61	0.09	0.70	FALSE
5	GTEx	Cells Transformed fibroblasts	UBE2Z	0.18	0.00	lasso	5	0.01	3.0e-02	-8.96	8.7	3.3e-18	0.28	0.06	0.20	TRUE
6	GTEx	Cells Transformed fibroblasts	AC091133.1	0.14	0.07	enet	22	0.09	1.9e-07	4.59	-6.3	3.4e-10	-0.63	0.63	0.35	TRUE
7	GTEx	Cells Transformed fibroblasts	RP11-463M16.4	0.10	0.00	enet	21	0.01	2.8e-02	4.37	-6.1	1.1e-09	-0.51	0.11	0.62	FALSE
8	GTEx	Heart Atrial Appendage	ATP5G1	0.22	0.10	enet	6	0.13	1.3e-06	3.58	-5.3	1.1e-07	-0.64	0.93	0.03	FALSE
9	GTEx	Heart Left Ventricle	ATP5G1	0.24	0.22	lasso	4	0.22	9.3e-12	4.25	-5.3	1.1e-07	-0.64	1.00	0.00	FALSE
10	GTEx	Muscle Skeletal	ATP5G1	0.13	0.08	enet	18	0.07	5.1e-07	4.55	-6.4	1.9e-10	-0.70	0.98	0.02	TRUE
11	GTEx	Muscle Skeletal	UBE2Z	0.06	0.02	lasso	8	0.03	9.8e-04	4.25	-8.2	2.6e-16	-0.81	0.12	0.84	FALSE
12	GTEx	Testis	HOXB3	0.19	0.00	lasso	6	0.03	2.1e-02	-0.23	-5.9	3.2e-09	-0.32	0.11	0.14	FALSE
13	GTEx	Testis	CALCOCO2	0.26	0.24	lasso	2	0.24	8.2e-11	6.10	5.9	2.8e-09	0.25	0.99	0.00	FALSE
14	GTEx	Testis	SNF8	0.23	0.11	lasso	5	0.08	1.6e-04	3.53	-5.4	6.0e-08	-0.64	0.47	0.37	FALSE
15	GTEx	Testis	HOXB2	0.21	0.00	enet	22	0.07	5.9e-04	2.22	-5.8	8.9e-09	-0.23	0.19	0.08	FALSE
16	GTEx	Testis	HOXB-AS1	0.18	-0.01	enet	35	0.04	5.3e-03	-1.51	-8.8	1.0e-18	-0.45	0.12	0.15	TRUE
17	GTEx	Whole Blood	UBE2Z	0.08	0.01	lasso	6	0.02	4.9e-03	9.87	9.5	1.9e-21	0.88	0.05	0.95	FALSE
18	METSIM	Adipose	HOXB9	0.06	0.03	enet	17	0.05	9.9e-08	4.74	-5.8	7.4e-09	-0.11	1.00	0.00	TRUE
19	METSIM	Adipose	UBE2Z	0.06	0.06	enet	16	0.04	3.2e-06	9.89	9.9	3.6e-23	0.93	0.23	0.77	FALSE
20	YFS	Blood	UBE2Z	0.06	0.03	enet	19	0.06	1.5e-18	5.47	5.3	1.2e-07	0.24	1.00	0.00	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNF8	0.01	0.01	blup	47	0.01	9.1e-03	9.84	-8.2	1.9e-16	-0.87	0.05	0.30	FALSE
22	The Cancer Genome Atlas	Glioblastoma Multiforme	SNF8	0.09	0.06	blup	47	0.07	4.3e-03	7.71	-8.2	2.1e-16	-0.87	0.06	0.44	FALSE
23	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HOXB7	0.03	0.03	enet	4	0.03	6.0e-04	6.14	-5.9	3.9e-09	0.11	0.06	0.75	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNF8	0.05	0.01	blup	47	0.03	2.1e-04	3.48	-6.6	3.6e-11	-0.78	0.07	0.56	FALSE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF652	0.03	0.03	enet	5	0.03	2.6e-04	-5.69	6.1	9.2e-10	-0.08	0.01	0.98	FALSE
26	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SNF8	0.03	0.01	blup	47	0.03	1.0e-02	10.18	-8.5	1.6e-17	-0.91	0.02	0.64	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	CALCOCO2	0.03	0.00	blup	50	0.01	1.9e-02	-6.21	-6.6	3.1e-11	-0.62	0.06	0.47	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	TTLL6	0.03	0.00	blup	59	0.02	2.7e-03	7.33	5.6	2.3e-08	0.56	0.02	0.82	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF652	0.06	0.03	lasso	4	0.02	1.6e-03	-5.59	5.3	1.4e-07	-0.04	0.11	0.76	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	ATP5G1	0.04	0.01	enet	6	0.03	5.4e-05	9.84	8.2	2.9e-16	0.81	0.01	0.94	FALSE
31	The Cancer Genome Atlas	Lung Adenocarcinoma	CALCOCO2	0.04	0.03	blup	50	0.02	1.6e-03	3.15	5.2	2.2e-07	0.26	0.03	0.06	FALSE
32	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF652	0.05	0.02	blup	55	0.02	2.5e-03	-6.59	5.5	4.5e-08	-0.09	0.01	0.98	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	SNF8	0.05	0.06	blup	47	0.06	1.0e-06	3.88	-6.6	4.7e-11	-0.79	0.52	0.47	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	TTLL6	0.03	0.04	lasso	2	0.03	3.4e-04	-8.08	8.1	6.3e-16	0.52	0.05	0.83	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	HOXB6	0.04	0.00	blup	51	0.01	3.3e-02	5.96	-6.6	5.5e-11	0.03	0.01	0.82	TRUE