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chr19:17,844,325-20,489,861

Best TWAS P=1.76e-19 · Best GWAS P=2.74e-15 conditioned to 0.477

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HAPLN4	0.07	0.10	lasso	6	0.10	5.3e-12	6.8	6.4	1.6e-10	0.95	0.05	0.95	FALSE
2	GTEx	Artery Tibial	SSBP4	0.09	0.04	lasso	5	0.00	3.0e-01	-5.3	5.3	1.1e-07	0.01	0.02	0.97	FALSE
3	GTEx	Brain Cerebellar Hemisphere	ATP13A1	0.19	0.15	lasso	2	0.07	7.3e-03	5.8	5.7	1.2e-08	0.68	0.07	0.44	FALSE
4	GTEx	Brain Cerebellum	ATP13A1	0.17	0.03	enet	30	0.03	5.2e-02	3.4	6.3	3.6e-10	0.58	0.06	0.38	FALSE
5	GTEx	Brain Hippocampus	DDX49	0.23	-0.01	lasso	4	-0.01	6.6e-01	-5.9	5.5	3.7e-08	0.21	0.05	0.06	FALSE
6	GTEx	Brain Nucleus accumbens basal ganglia	ELL	0.17	0.00	lasso	5	0.01	2.1e-01	-5.4	5.1	2.7e-07	0.03	0.02	0.85	FALSE
7	GTEx	Cells Transformed fibroblasts	SSBP4	0.09	0.07	lasso	2	0.06	5.5e-05	-5.6	5.6	2.7e-08	0.03	0.02	0.98	FALSE
8	GTEx	Colon Transverse	YJEFN3	0.09	0.09	lasso	3	0.07	4.3e-04	7.7	-7.8	5.3e-15	-0.93	0.02	0.95	FALSE
9	GTEx	Esophagus Mucosa	LPAR2	0.08	0.03	lasso	2	0.01	1.1e-01	6.1	-6.3	4.0e-10	-0.72	0.12	0.62	FALSE
10	GTEx	Esophagus Mucosa	GATAD2A	0.11	0.02	lasso	3	0.02	2.3e-02	-6.1	-5.7	1.4e-08	-0.15	0.14	0.05	FALSE
11	GTEx	Lung	LPAR2	0.07	0.09	lasso	3	0.05	9.9e-05	5.9	-5.6	2.0e-08	-0.74	0.54	0.40	FALSE
12	GTEx	Muscle Skeletal	SUGP1	0.11	0.06	lasso	7	0.07	9.5e-08	6.8	-5.8	5.1e-09	-0.94	0.05	0.95	FALSE
13	GTEx	Muscle Skeletal	SSBP4	0.09	0.07	lasso	3	0.07	1.3e-07	-5.3	5.8	6.9e-09	0.03	0.01	0.99	TRUE
14	GTEx	Nerve Tibial	LPAR2	0.14	0.05	lasso	5	0.06	2.3e-05	5.9	-5.6	2.1e-08	-0.69	0.66	0.11	FALSE
15	GTEx	Skin Sun Exposed Lower leg	SSBP4	0.12	0.12	lasso	3	0.11	2.9e-09	-5.4	5.4	5.9e-08	0.02	0.02	0.98	FALSE
16	GTEx	Spleen	LPAR2	0.27	0.06	lasso	6	0.04	2.7e-02	3.3	-5.9	4.0e-09	-0.76	0.04	0.66	FALSE
17	GTEx	Thyroid	SSBP4	0.09	0.11	lasso	6	0.10	8.2e-08	-5.4	5.1	2.8e-07	0.02	0.01	0.99	FALSE
18	GTEx	Thyroid	YJEFN3	0.05	0.02	lasso	3	0.02	1.2e-02	7.4	-5.9	3.0e-09	-0.87	0.02	0.91	FALSE
19	GTEx	Whole Blood	LPAR2	0.10	0.07	lasso	5	0.07	8.0e-07	5.9	-6.6	4.4e-11	-0.83	0.10	0.89	FALSE
20	METSIM	Adipose	ELL	0.08	0.05	lasso	7	0.06	7.1e-09	-5.3	-5.6	1.8e-08	-0.03	0.02	0.98	FALSE
21	NTR	Blood	LPAR2	0.04	0.03	lasso	3	0.03	3.6e-11	5.9	-5.4	6.5e-08	-0.67	0.96	0.04	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	ELL	0.27	0.39	lasso	7	0.39	4.0e-53	-5.4	5.3	1.4e-07	0.02	0.02	0.98	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	TSSK6	0.04	0.00	blup	346	0.01	1.1e-02	7.3	5.5	3.8e-08	0.78	0.02	0.94	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	HAPLN4	0.05	0.03	enet	15	0.03	1.7e-04	3.7	5.3	1.5e-07	0.80	0.16	0.84	FALSE
25	YFS	Blood	LPAR2	0.14	0.15	lasso	5	0.16	3.6e-48	6.1	-5.4	6.5e-08	-0.68	1.00	0.00	FALSE
26	YFS	Blood	ZNF101	0.02	0.00	enet	16	0.01	2.7e-03	-4.1	-6.3	3.1e-10	-0.38	0.15	0.05	FALSE
27	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	YJEFN3	0.04	0.05	lasso	7	0.04	1.6e-04	7.8	-7.0	2.1e-12	-0.97	0.01	0.97	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	CILP2	0.02	0.02	blup	30	0.02	1.6e-04	7.8	7.5	7.2e-14	0.97	0.01	0.96	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	HAPLN4	0.04	0.07	lasso	4	0.06	1.3e-12	6.8	5.9	4.1e-09	0.93	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	YJEFN3	0.03	0.02	enet	18	0.02	2.1e-04	7.8	-7.2	7.6e-13	-0.71	0.01	0.98	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	TSSK6	0.07	0.02	blup	32	0.04	2.9e-03	7.7	9.0	1.8e-19	0.89	0.01	0.83	TRUE
32	The Cancer Genome Atlas	Glioblastoma Multiforme	ELL	0.13	0.10	blup	46	0.08	1.9e-03	-5.3	5.1	3.1e-07	0.01	0.02	0.88	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TM6SF2	0.04	0.03	blup	35	0.03	2.5e-04	-5.6	-6.4	2.1e-10	-0.22	0.38	0.06	FALSE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	YJEFN3	0.03	0.03	blup	32	0.02	3.0e-03	7.7	-8.8	1.1e-18	-0.94	0.01	0.92	FALSE
35	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TSSK6	0.35	0.01	blup	33	0.09	2.8e-04	-1.2	5.3	9.2e-08	0.31	0.00	0.06	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	YJEFN3	0.04	0.05	lasso	2	0.05	4.3e-06	7.8	-7.8	6.9e-15	-1.00	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Stomach Adenocarcinoma	HAPLN4	0.08	0.03	blup	37	0.04	7.2e-04	6.8	5.2	1.9e-07	0.82	0.01	0.98	FALSE
38	The Cancer Genome Atlas	Thyroid Carcinoma	YJEFN3	0.08	0.06	blup	33	0.08	7.1e-08	7.8	-8.9	6.4e-19	-0.94	0.01	0.99	FALSE