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chr1:18,704,862-24,216,118

Best TWAS P=2.54e-53 · Best GWAS P=9.95e-41 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CAPZB	0.13	0.16	lasso	4	0.16	1.8e-19	5.83	-6.7	2.1e-11	0.01	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	HTR1D	0.11	0.07	enet	21	0.09	1.1e-10	-6.41	6.8	7.9e-12	0.02	0.16	0.84	FALSE
3	GTEx	Artery Aorta	CAPZB	0.14	0.10	lasso	6	0.10	5.0e-06	7.80	-7.6	3.3e-14	0.00	0.90	0.08	FALSE
4	GTEx	Artery Coronary	CAPZB	0.25	0.02	enet	22	0.03	3.3e-02	6.35	-5.4	5.9e-08	-0.01	0.08	0.08	FALSE
5	GTEx	Artery Tibial	CAPZB	0.09	0.07	lasso	4	0.06	8.1e-06	6.17	-7.5	6.8e-14	0.00	0.60	0.20	FALSE
6	GTEx	Artery Tibial	LUZP1	0.25	0.02	enet	51	0.11	3.4e-09	-6.79	5.5	4.8e-08	0.04	0.16	0.76	FALSE
7	GTEx	Brain Cerebellar Hemisphere	AKR7L	0.26	0.00	enet	4	-0.01	7.3e-01	4.37	6.8	1.2e-11	-0.01	0.06	0.45	FALSE
8	GTEx	Brain Hippocampus	LINC00339	0.41	0.08	lasso	8	0.13	5.1e-04	5.47	5.9	3.4e-09	0.63	0.05	0.68	TRUE
9	GTEx	Brain Putamen basal ganglia	OTUD3	0.36	0.11	enet	16	0.04	4.7e-02	-2.89	-7.1	9.9e-13	0.03	0.04	0.48	FALSE
10	GTEx	Cells Transformed fibroblasts	UBR4	0.24	0.05	enet	26	0.09	1.8e-07	0.62	5.2	2.6e-07	0.10	0.90	0.02	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	MUL1	0.32	0.24	lasso	5	0.28	1.7e-10	4.49	5.2	1.8e-07	0.00	0.41	0.52	FALSE
12	GTEx	Esophagus Muscularis	LUZP1	0.17	0.15	enet	20	0.16	8.8e-10	-6.41	5.3	1.4e-07	0.04	0.16	0.84	FALSE
13	GTEx	Esophagus Muscularis	RP1-184J9.2	0.07	0.08	enet	6	0.05	6.1e-04	-6.38	6.6	4.9e-11	0.03	0.29	0.60	FALSE
14	GTEx	Lung	PQLC2	0.12	0.10	lasso	3	0.08	1.0e-06	-5.58	5.3	9.6e-08	0.01	0.98	0.00	FALSE
15	GTEx	Nerve Tibial	PQLC2	0.07	0.08	lasso	3	0.06	6.6e-05	-7.56	7.6	3.7e-14	-0.01	0.52	0.32	FALSE
16	GTEx	Nerve Tibial	CAPZB	0.07	0.03	enet	14	0.01	3.5e-02	7.93	-6.6	4.8e-11	0.02	0.66	0.04	FALSE
17	GTEx	Pancreas	LINC00339	0.33	0.18	enet	12	0.18	3.5e-08	5.47	-9.2	5.0e-20	-0.71	0.09	0.89	FALSE
18	GTEx	Skin Sun Exposed Lower leg	KDM1A	0.09	0.01	lasso	5	0.01	1.1e-01	-5.87	-6.5	7.5e-11	0.05	0.01	0.93	FALSE
19	GTEx	Skin Sun Exposed Lower leg	MUL1	0.37	0.21	lasso	7	0.29	4.4e-24	4.49	5.2	2.5e-07	0.03	0.42	0.56	FALSE
20	GTEx	Small Intestine Terminal Ileum	KIF17	0.24	0.04	lasso	7	0.02	1.3e-01	-5.37	-5.3	9.7e-08	-0.01	0.03	0.74	TRUE
21	GTEx	Testis	LUZP1	0.17	0.09	lasso	4	0.08	2.6e-04	-5.96	-7.1	1.2e-12	0.05	0.03	0.88	TRUE
22	GTEx	Thyroid	CAPZB	0.22	0.06	lasso	8	0.15	1.1e-11	7.37	-5.4	7.3e-08	0.00	0.80	0.20	FALSE
23	GTEx	Uterus	ALPL	0.42	-0.01	lasso	8	0.02	1.4e-01	2.36	-6.6	3.4e-11	0.03	0.04	0.06	TRUE
24	GTEx	Whole Blood	HP1BP3	0.04	0.04	lasso	4	0.02	6.3e-03	-5.17	-5.2	1.7e-07	0.01	0.42	0.44	FALSE
25	GTEx	Whole Blood	LINC00339	0.23	0.11	lasso	5	0.14	1.2e-12	9.80	8.3	6.8e-17	0.70	0.99	0.01	TRUE
26	ROSMAP	Brain Pre-frontal Cortex	PQLC2	0.13	0.05	lasso	8	0.10	2.7e-12	7.51	7.4	1.1e-13	0.00	1.00	0.00	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	CDC42	0.07	0.02	lasso	6	0.04	5.7e-06	5.92	10.9	1.9e-27	0.76	0.03	0.96	TRUE
28	ROSMAP	Brain Pre-frontal Cortex	CAPZB	0.28	0.39	lasso	4	0.38	9.4e-52	5.80	-5.9	4.7e-09	0.01	1.00	0.00	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	HTR1D	0.10	0.10	lasso	4	0.12	1.3e-14	-6.41	6.8	1.1e-11	0.05	0.36	0.64	FALSE
30	YFS	Blood	CAPZB	0.06	0.10	bslmm	534	0.09	5.1e-29	5.80	-5.3	9.2e-08	0.00	1.00	0.00	FALSE
31	YFS	Blood	LUZP1	0.01	0.00	blup	407	0.01	1.8e-03	5.77	6.2	5.6e-10	0.10	0.15	0.34	TRUE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	WNT4	0.03	0.01	blup	72	0.02	3.8e-05	11.21	15.4	2.5e-53	0.43	0.46	0.09	TRUE
33	The Cancer Genome Atlas	Colon Adenocarcinoma	HTR1D	0.10	0.07	enet	7	0.08	3.8e-05	-6.88	6.1	8.9e-10	0.01	0.17	0.76	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CAPZB	0.03	0.00	blup	160	0.01	3.3e-02	-7.72	-8.9	6.9e-19	0.04	0.05	0.72	TRUE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LUZP1	0.25	0.01	enet	31	0.05	2.0e-06	-6.75	5.3	1.2e-07	0.04	0.08	0.56	FALSE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	MUL1	0.08	0.02	blup	57	0.06	4.9e-08	2.85	5.7	1.6e-08	0.02	0.02	0.84	TRUE
37	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HTR1D	0.24	0.12	lasso	4	0.12	1.2e-05	-5.96	6.3	2.9e-10	-0.04	0.37	0.49	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	WNT4	0.05	0.01	blup	69	0.01	1.1e-02	6.12	-7.1	1.3e-12	0.09	0.04	0.03	TRUE
39	The Cancer Genome Atlas	Rectum Adenocarcinoma	HTR1D	0.19	0.12	enet	11	0.13	7.3e-04	-4.58	5.1	2.9e-07	0.01	0.07	0.25	FALSE
40	The Cancer Genome Atlas	Rectum Adenocarcinoma	MUL1	0.30	0.05	blup	57	0.05	2.8e-02	4.48	5.1	2.7e-07	0.02	0.00	0.27	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	CAPZB	0.08	0.06	blup	160	0.07	1.2e-07	6.16	-6.5	7.1e-11	0.00	0.05	0.95	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	WNT4	0.14	0.06	blup	70	0.12	9.7e-12	-4.32	-7.9	3.9e-15	0.04	1.00	0.00	TRUE