Hub : Genes

AKR7L

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.2590	0.0990	2.1e-03	0.001	NA	-0.010	NA	-0.012	3.1e-01	NA	7.3e-01	NA	9.7e-01
2	GTEx	Brain Cerebellum	0.1890	0.0780	7.6e-03	-0.008	NA	0.024	NA	0.007	6.8e-01	NA	6.3e-02	NA	2.0e-01
3	GTEx	Brain Frontal Cortex BA9	0.2124	0.0781	2.4e-03	0.060	NA	0.028	NA	0.037	1.1e-02	NA	6.1e-02	NA	3.7e-02
4	GTEx	Breast Mammary Tissue	0.2440	0.0860	5.3e-03	-0.005	NA	0.000	NA	-0.002	7.1e-01	NA	3.1e-01	NA	4.3e-01
5	GTEx	Breast Mammary Tissue (Female)	0.2618	0.1451	3.9e-02	0.025	NA	-0.010	NA	0.012	6.1e-02	NA	9.6e-01	NA	1.4e-01
6	GTEx	Nerve Tibial	0.1672	0.0795	8.3e-03	-0.004	NA	-0.001	NA	-0.003	9.9e-01	NA	4.3e-01	NA	6.4e-01
7	ROSMAP	Brain Pre-frontal Cortex	0.0690	0.0254	4.0e-04	0.018	0.032	0.031	0.042	0.031	1.9e-03	4.6e-05	7.0e-05	4.1e-06	6.8e-05
8	TCGA	Breast Invasive Carcinoma	0.0783	0.0291	6.4e-10	0.051	0.048	0.058	NA	0.058	1.0e-10	4.2e-10	6.9e-12	NA	6.8e-12
9	TCGA	Soft Tissue Sarcoma	0.0880	0.0440	1.9e-03	0.007	0.042	0.019	NA	0.006	1.1e-01	1.7e-03	2.5e-02	NA	1.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	0.5	0.9	4.8	1.4	-0.4	0.4	2.2	0.6	0.3	0.6	0.1	-0.1
Bipolar Disorder or Schizophrenia	0.6	1.5	3.0	1.3	0.9	1.5	1.6	0.5	0.8	1.7	-1.0	1.2
Depressed Affect (Nagel 2018)	0.5	1.2	3.5	0.8	0.7	1.6	0.0	-1.9	0.5	0.9	-1.4	0.1
Depression (Nagel 2018)	0.5	0.7	2.9	-0.4	-0.9	0.2	1.7	0.4	-0.8	-0.9	0.4	-0.8
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.3	1.0	0.3	1.0	-1.5	0.9	0.1	0.4	-0.3	0.7
Neuroticism (Nagel 2018)	2.4	5.6	11.3	2.1	2.4	3.4	0.8	-1.7	1.5	2.8	-3.0	2.5
Schizophrenia (2018)	0.7	1.5	3.0	0.6	1.5	1.6	0.4	0.2	0.8	1.7	-1.4	1.7
Schizophrenia vs Biploar Disorder	0.4	0.5	1.1	-0.5	0.6	0.5	-1.0	-0.5	0.7	0.5	-1.1	0.7
Worry (Nagel 2018)	4.0	8.5	14.2	3.0	3.2	3.6	1.4	-1.5	1.6	3.4	-3.5	3.8
Alzheimer’s Disease (in mother)	1.0	1.2	2.3	0.6	1.5	1.4	-1.1	-0.3	0.9	0.9	-0.9	1.5
Alzheimer’s Disease (in father)	1.5	1.6	3.2	1.5	0.7	1.1	0.7	0.6	1.4	1.3	-1.6	1.8
Alzheimer’s Disease (including proxy)	1.8	2.7	4.9	2.2	1.6	2.2	-0.4	-0.3	1.4	1.5	-1.6	2.1
Crohns Disease (2017)	0.8	1.7	2.3	0.9	1.4	0.8	1.4	1.3	1.0	1.5	-1.5	1.5
Irritable Bowel Disease (IBD)	0.5	1.2	2.4	0.6	1.1	1.1	-0.3	1.0	-1.0	1.4	-1.2	1.5
Ulcerative Colitis (UC)	0.8	1.4	6.6	-0.1	0.2	0.6	-2.1	0.3	-2.6	0.8	-0.2	0.7
Major Depression (MDD)	0.7	0.9	3.3	-0.4	0.9	0.3	1.1	0.0	1.8	0.6	-0.9	1.1
Reaction Time	0.5	0.9	2.8	-1.0	-0.3	0.1	-1.1	1.7	-1.5	0.3	0.9	0.3
Verbal and Numeric Reasoning (VNR)	0.3	0.6	3.8	0.7	-0.3	0.6	-1.9	-0.1	-0.1	-0.7	0.1	-0.5
Breast Cancer	0.2	0.5	2.3	-0.3	-0.2	1.2	-1.5	-0.7	0.2	-0.1	0.3	-0.2
Ovarian Cancer	0.6	0.7	4.9	2.2	-0.0	0.6	0.4	-0.2	-0.6	-0.8	-0.5	-0.0
Prostate Cancer	0.2	0.2	1.0	-0.2	-0.4	1.0	0.1	-0.3	-0.8	0.1	0.2	-0.4
Age at First Birth	1.6	2.3	5.5	0.5	-2.4	-1.6	1.0	1.7	-1.6	-1.3	2.1	-0.3
Bipolar Disorder (2011)	2.2	2.1	5.5	1.0	1.8	1.8	-0.2	-0.5	0.3	2.1	-2.3	1.2
Body Mass Index (BMI) (2010)	1.7	2.3	4.3	-0.8	-1.8	-2.1	-1.3	1.2	-1.5	-1.6	1.6	-1.3
Coronary Artery Disease (CAD)	0.2	0.3	0.8	-0.8	0.2	-0.3	-0.1	-0.7	0.9	0.2	0.6	-0.1
Crohns Disease (2012)	1.4	2.3	6.1	1.2	1.5	1.2	2.5	0.8	1.9	1.2	-1.1	1.7
Mean Putamen Volume	2.2	2.5	12.9	0.1	-0.9	-1.0	3.6	1.5	2.2	-0.3	0.7	-0.4
Fasting Glucose	0.1	0.2	0.6	0.4	-0.6	-0.1	0.6	-0.1	-0.1	-0.8	-0.0	-0.4
HbA1C	0.3	0.3	2.0	0.3	-0.1	-0.8	-1.4	0.3	0.2	0.1	0.0	-0.2
HDL Cholesterol	0.7	1.2	4.0	-0.2	0.5	-1.3	-1.0	-2.0	0.9	-1.1	-1.2	-0.1
LDL Cholesterol	0.3	0.5	2.0	0.3	-0.9	-0.2	-0.8	0.4	-1.4	-0.6	0.3	-0.6
Lupus	0.7	1.0	2.5	-0.9	-1.2	-0.5	0.6	0.2	-1.0	-1.6	0.7	-1.6
Neuroticism (2016)	2.5	3.6	10.0	0.6	1.9	2.6	1.4	-0.3	1.7	3.2	-1.2	2.3
Primary Biliary Cirrhosis	0.6	0.9	3.0	0.9	-0.7	-1.3	0.6	-0.5	0.0	-1.7	0.9	-0.8
Rheumatoid Arthritis	0.5	0.6	1.3	0.4	1.1	0.4	-0.8	-0.8	1.1	0.6	-0.9	0.8
Schizophrenia (2014)	0.4	0.8	1.9	0.5	0.8	0.8	0.6	0.4	1.0	1.4	-1.0	1.2
Triglycerides	0.3	0.4	2.2	0.3	-0.5	0.3	-1.5	0.7	-0.2	-0.2	0.6	-0.2
Type 2 Diabetes (T2D) (2012)	0.7	0.9	1.7	1.3	0.7	-0.3	1.3	-0.2	-0.4	1.0	-1.1	1.1
Ulcerative Colitis	0.5	0.7	2.2	-0.0	1.0	0.9	-1.5	-0.5	-0.5	0.7	-1.0	0.8
Blood Eosinophil Count	0.1	0.7	2.3	-0.0	-0.5	-0.7	-0.9	-0.1	0.1	-1.3	0.8	-1.5
Blood Platelet Count	0.1	1.2	6.2	2.5	0.3	1.2	-0.4	0.3	0.1	-1.6	-0.6	-0.1
Blood Red Count	0.2	2.4	7.1	0.7	-2.2	-0.4	1.2	0.9	-2.7	-2.2	0.6	-1.2
Blood White Count	0.5	3.5	8.1	-0.4	-2.8	-1.1	1.0	2.7	-0.9	-1.9	2.4	-2.0
Heel T-Score	0.2	1.2	4.1	-1.3	-0.0	-0.8	-0.6	-1.9	0.2	2.0	0.8	0.0
BMI	0.3	1.6	4.7	-0.6	-1.9	-2.2	0.3	-0.5	-0.3	-1.2	0.9	-1.6
Height	0.7	13.3	57.8	7.6	2.1	2.0	5.0	3.5	0.0	2.1	-2.1	2.7
Waist Hip Ratio (WHR)	0.3	1.2	5.1	-0.5	-0.6	-0.6	-2.0	-0.7	-2.2	0.1	-0.2	-0.6
Systolic Blood Pressure	0.2	0.9	2.4	1.5	0.7	0.6	1.4	0.7	1.0	-0.9	-0.9	-0.3
Smoking Status	0.2	0.5	1.3	0.8	1.1	1.1	0.0	-0.5	0.4	0.7	-0.2	0.7
Allergy or Eczema	0.3	0.8	2.2	1.4	-0.1	-0.3	0.9	-1.5	0.2	-1.3	0.1	-0.6
Cardiovascular Disease	0.2	0.7	2.0	-0.6	-1.2	-0.3	0.6	0.4	-0.5	-0.9	0.9	-1.4
Hypothyroidism (self reported)	3.7	8.5	21.3	-2.8	-1.3	-4.6	-2.1	-2.6	-2.0	-3.1	2.2	-3.9
Respiratory disease	0.3	0.8	3.7	0.0	-1.0	-0.5	1.9	1.1	-0.3	0.1	0.6	-0.5
Type 2 Diabetes (T2D) (2018)	1.7	3.2	7.4	0.7	-2.7	-0.3	-1.7	0.0	-2.6	-1.7	1.1	-2.7
Lung FEV1/FVC ratio	0.4	1.8	5.5	2.4	1.2	0.1	-1.0	-0.6	1.4	-2.1	-1.3	-0.1
Lung FVC	0.4	1.9	6.5	-0.7	1.6	0.3	-2.1	-2.5	-0.6	-0.4	-1.4	0.7
Neuroticism	2.2	5.2	10.4	2.2	2.4	3.2	0.6	-2.0	1.1	2.4	-3.1	2.2
Chronotype (morning person)	0.8	1.9	3.1	1.3	-1.6	-1.5	1.2	-1.4	-1.8	-1.5	0.4	-1.5
Hair Pigment	0.0	0.9	2.9	1.7	0.5	0.7	-0.4	1.2	0.6	0.9	-0.8	0.9
Tanning	0.2	3.0	7.8	-1.7	-2.0	-1.2	1.2	0.2	-0.3	-2.4	1.9	-2.8
Hand grip strength (left)	0.6	1.6	5.2	2.3	0.8	1.2	1.1	1.1	0.7	1.5	-0.8	1.1
Number of treatments/medications taken	0.8	1.5	5.4	-0.6	-0.4	0.0	1.9	2.3	0.4	1.2	0.4	1.5
Average weekly spirits intake	0.2	0.2	0.8	0.2	-0.1	0.1	-0.3	-0.4	-0.9	-0.6	0.4	-0.6
Sensitivity / hurt feelings	0.8	1.4	5.3	0.8	0.8	2.3	-0.1	-0.8	0.6	1.7	-1.1	0.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.4	0.7	-0.0	1.2	0.4	-0.9	-0.4	-0.2	-0.0	-0.2
Hearing difficulty/problems: Yes	0.2	0.3	1.4	-0.5	0.3	0.1	-0.1	-1.2	0.1	-0.1	-0.5	-0.6
Relative age of first facial hair	0.1	0.2	0.6	-0.2	0.4	-0.1	0.8	0.3	0.3	-0.3	0.5	-0.5
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.1	-1.5	-1.0	-0.1	0.1	0.6	0.5	-0.7	1.4	-1.0
Ever used hormone-replacement therapy (HRT)	2.5	3.2	4.6	1.8	2.1	2.0	0.6	-1.3	1.8	2.0	-2.1	1.8
Ever had hysterectomy (womb removed)	1.7	1.9	5.3	0.7	-2.3	-0.3	-0.3	0.4	-2.3	-1.4	1.2	-1.6
Systolic blood pressure, automated reading	1.0	3.0	6.4	1.6	2.1	2.1	0.3	0.7	0.4	1.7	-2.3	2.5
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	5.8	0.2	-1.9	-0.9	0.9	0.1	-0.4	-1.2	1.1	-2.4
Angina	0.8	1.0	2.2	1.3	0.0	1.4	1.5	-1.4	0.3	-0.2	-0.9	-0.9
Medication for hormone replacement therapy	0.2	0.3	0.6	0.6	-0.4	0.6	0.8	-0.6	0.0	-0.1	0.2	-0.7
Vitamin and mineral supplements	0.4	0.5	1.1	-1.1	-0.2	-1.0	-1.0	0.3	0.3	-0.6	0.7	-0.4
Supplements: Zinc	0.5	0.6	3.0	1.7	0.4	-0.3	0.4	-0.4	0.3	-0.6	-1.0	0.1
Medication: Co-codamol	0.8	1.0	2.4	-0.7	-1.5	-0.7	1.0	0.7	-0.5	-1.5	0.3	-1.2
Medication: Metformin	1.5	2.1	4.5	1.8	-2.1	0.2	0.6	1.0	-2.1	-0.8	1.3	-1.6
Diabetes (father)	1.8	2.2	5.3	-1.2	-1.7	-0.8	1.1	0.3	-2.3	-0.7	1.7	-2.2
Diabetes (mother)	0.4	0.5	1.3	-0.9	-0.3	-0.1	-1.1	-0.9	-0.1	0.0	0.6	-0.9
Severe depression (siblings)	1.4	1.6	4.2	0.9	1.4	1.1	0.4	-2.1	1.2	1.6	-1.2	0.7
Pack years adult smoking proportion	3.3	5.1	8.7	-2.2	-2.8	-2.4	0.8	1.7	-1.9	-2.3	3.0	-2.5
Impedance of leg (right)	0.0	0.2	0.5	-0.7	0.6	-0.2	0.5	0.4	-0.5	-0.0	-0.1	-0.1
Leg fat-free mass (left)	0.2	1.3	7.6	2.8	-1.1	-0.7	0.3	0.5	-0.8	-0.9	0.1	-0.7
Trunk fat percentage	0.0	0.2	0.8	-0.2	-0.6	-0.9	0.4	0.4	0.1	0.4	-0.1	0.2
Hand grip strength (right)	0.3	0.9	5.1	2.3	0.6	0.9	0.9	0.6	-0.2	0.6	-0.8	0.0
Townsend deprivation index at recruitment	0.7	1.0	3.3	1.8	0.8	0.6	-0.4	-0.8	-0.3	0.3	-1.5	1.1
Current tobacco smoking	0.6	1.0	4.2	2.0	1.2	1.1	-0.7	-0.9	0.3	-0.4	-0.8	0.2
Average weekly fortified wine intake	0.1	0.1	0.4	-0.3	0.3	-0.2	-0.3	0.6	-0.6	-0.0	-0.2	0.0
Maternal smoking around birth	0.5	0.8	2.1	-1.1	-1.2	-0.8	0.6	-0.6	0.3	-0.6	0.7	-1.5
Fed-up feelings	0.7	1.3	5.0	0.2	0.9	2.2	-0.2	-0.5	1.5	1.6	-0.7	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.8	0.1	-0.1	0.7	0.9	0.2	-0.5	-0.4	-0.0	0.2
Relative age voice broke	0.2	0.4	1.7	-0.4	0.4	0.2	-1.3	-0.2	-0.8	0.2	0.1	-0.7
Taking other prescription medications	0.5	0.7	3.4	-0.6	-0.5	-0.6	0.6	1.9	-0.1	0.5	0.9	0.7
Age when periods started (menarche)	0.4	0.9	3.5	-0.8	1.9	-0.2	-1.4	-1.0	0.3	-0.2	-1.1	0.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.7	1.3	-0.1	1.1	0.1	-0.3	-0.6	0.6	-0.6	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	5.7	-1.6	-2.1	-2.4	0.8	-1.2	-1.1	-0.6	1.3	-2.1
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	5.2	-0.4	0.6	1.2	0.4	0.6	1.1	2.3	0.5	2.2
Qualifications: CSEs or equivalent	0.6	0.9	3.2	-0.7	-0.3	-0.2	-1.8	-1.5	-0.5	-0.4	-0.2	-1.1
Serious illness, injury or assault to yourself	0.3	0.3	1.0	0.0	-0.6	-0.6	0.4	-0.4	0.6	-1.0	0.6	-0.5
High blood pressure	0.3	0.8	4.0	1.1	0.1	2.0	0.7	0.7	-0.2	0.8	-0.2	0.8
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.2	0.7	0.8	-0.1	0.2	-1.0	1.1	-0.2	-0.4	0.6
Multivitamins +/- minerals	0.3	0.4	0.9	0.9	0.7	0.5	0.0	0.0	-0.1	0.4	-0.9	0.9
Stomach or abdominal pain in last month	1.3	1.7	3.6	1.1	-1.0	-0.5	-0.1	-1.9	-1.7	-1.7	-0.4	-1.6
Supplements: Glucosamine	0.2	0.2	0.7	0.1	-0.1	-0.3	0.3	0.7	-0.2	0.1	0.7	0.8
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	2.7	-1.1	0.7	-0.3	-0.7	1.2	-0.5	0.2	0.1	1.6
Medication: Atenolol	0.6	0.7	1.7	1.1	0.4	0.1	0.5	1.1	-0.6	0.8	-1.3	0.8
Medication: Levothyroxine sodium	2.4	4.1	13.9	-2.0	-1.3	-3.7	-0.8	-1.4	-1.3	-2.1	1.4	-2.7
Sitting height	1.0	6.9	46.0	6.8	0.4	1.3	2.1	2.4	-1.5	0.7	-0.9	0.9
Chronic bronchitis/emphysema (father)	0.3	0.3	1.3	-0.6	0.0	0.4	-1.1	-1.0	0.1	0.4	-0.2	-0.3
High blood pressure (mother)	0.6	0.9	4.3	-0.2	0.6	0.5	0.7	0.4	1.1	2.1	-0.1	1.0
Body mass index (BMI)	0.1	0.4	1.4	-0.2	-1.2	-1.0	-0.7	-0.2	-0.1	-0.6	0.3	-0.6
Impedance of leg (left)	0.0	0.2	0.4	-0.5	0.6	0.0	0.6	0.5	-0.4	0.4	-0.2	0.1
Leg predicted mass (left)	0.3	1.4	7.5	2.7	-1.2	-0.8	0.4	0.5	-0.9	-1.0	0.2	-0.8
Trunk fat mass	0.1	0.5	1.1	0.9	-1.0	-1.0	0.7	0.8	-0.2	0.1	0.0	-0.0
Waist circumference	0.2	0.6	2.2	0.1	-1.0	-1.5	-0.5	0.3	-1.2	-0.2	0.3	-0.5
Number of incorrect matches in round	1.4	2.4	6.5	1.3	1.0	1.9	0.6	0.6	0.4	2.5	-1.6	2.2
Past tobacco smoking	1.1	2.0	6.1	1.0	-0.6	-1.2	-2.5	-0.6	-0.8	-2.0	-0.7	-1.9
Alcohol usually taken with meals	0.3	0.5	1.3	-0.3	-0.5	-0.6	1.2	1.0	-0.6	-0.1	1.0	-0.1
Nervous feelings	5.1	9.6	16.9	2.6	3.5	4.1	-0.2	-1.9	1.3	4.1	-3.9	3.7
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.9	0.8	-0.5	0.8	0.0	-1.2	-1.7	-0.8	0.1	-0.8
Hearing difficulty/problems with background noise	1.2	1.9	4.6	-0.4	-1.8	-1.8	0.6	-0.4	-0.4	-2.1	0.9	-2.1
Hair/balding pattern: Pattern 2	0.7	0.9	1.7	-1.2	-0.6	-0.9	-0.8	1.3	-0.8	-0.9	0.8	-1.3
Had menopause	0.9	1.1	6.2	-0.3	0.3	0.5	-0.2	2.5	1.0	0.6	0.7	1.1
Had other major operations	0.5	0.6	1.9	0.3	1.1	-0.0	0.0	0.8	0.4	1.4	-0.3	1.2
Forced vital capacity (FVC)	0.2	0.9	2.6	1.5	0.7	-0.4	-0.4	-1.0	-1.6	-0.9	-1.1	0.0
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	9.9	-2.2	-1.9	-3.1	1.1	-0.5	-0.5	-0.4	1.5	-2.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.4	-0.0	-0.1	1.0	0.0	-1.2	-0.4	0.2	0.3	0.1
Qualifications: None of the above	0.4	0.8	4.2	-2.0	0.0	-1.1	-0.8	0.0	-0.2	0.9	0.3	0.5
Financial difficulties in last 2 years	0.8	1.1	2.6	-1.0	-1.0	-1.6	0.8	-0.1	0.2	-1.3	0.8	-1.5
Mouth/teeth dental problems	0.2	0.3	0.8	0.8	0.5	0.9	0.2	-0.3	0.8	-0.2	-0.3	0.4
Heart attack	0.2	0.3	0.8	-0.6	-0.2	-0.0	-0.7	0.8	0.3	-0.4	0.9	0.2
Allergy	0.2	0.5	2.2	-0.1	0.4	0.9	-1.5	-0.3	-0.9	-0.1	-0.5	-0.4
Pain all over the body in last month	1.5	1.7	8.8	0.5	0.9	1.3	-3.0	-0.8	0.2	1.0	-0.9	0.9
Diabetes (self-reported)	2.2	3.3	8.9	0.5	-3.0	-0.3	-1.2	0.5	-2.4	-2.2	1.5	-2.5
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	3.4	1.2	1.8	0.0	-0.7	-0.5	1.2	1.4	-1.2	1.8
Medication: Ramipril	0.5	0.6	1.7	-0.7	-0.7	-1.2	0.2	-0.0	-0.9	-0.6	1.3	-0.6
Medication: Simvastatin	0.4	0.5	1.7	-0.4	-0.9	-0.7	0.3	1.3	0.3	-0.5	0.2	-1.0
Fluid intelligence score	0.2	0.4	1.3	1.1	-0.8	0.1	-1.2	0.4	-0.2	-0.3	0.3	-0.4
Illnesses of siblings	0.5	0.7	2.4	0.4	-0.4	-1.2	-0.3	-0.4	-1.0	-1.6	0.2	-1.0
Neuroticism score	1.8	3.7	9.0	1.2	1.8	3.0	0.4	-2.6	1.2	2.0	-2.3	1.4
Weight	0.2	0.9	4.4	2.1	-1.1	-0.9	0.4	0.6	-0.7	-0.6	0.1	-0.5
Impedance of arm (right)	0.1	0.6	2.3	-1.3	0.7	0.4	0.1	-1.5	-0.4	0.4	-0.4	-0.3
Arm fat percentage (right)	0.2	0.7	1.8	-1.0	-1.3	-1.3	-0.3	-0.2	-0.3	-0.7	0.4	-0.9
Trunk fat-free mass	0.4	2.1	14.1	3.8	-1.0	-0.3	0.8	1.2	-0.7	-1.0	0.3	-0.4
Hip circumference	0.3	1.1	3.7	0.2	-1.5	-1.9	0.6	0.4	-0.7	-1.2	0.6	-1.2
Time employed in main current job	0.2	0.2	0.6	-0.4	-0.4	0.2	0.7	0.4	-0.8	0.3	0.5	-0.1
Alcohol intake versus 10 years previously	0.4	0.6	2.0	0.1	-0.7	-0.7	-0.5	-0.5	-1.4	-0.7	-0.8	-0.8
Father’s age at death	0.6	0.8	1.7	0.6	1.3	0.8	-0.3	-0.5	1.1	1.1	-0.2	1.3
Worrier / anxious feelings	0.6	1.1	2.9	1.7	0.7	1.6	0.3	-0.9	-0.8	0.7	-1.2	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	-0.1	-0.4	0.5	-0.2	-0.7	-0.7	0.2	-0.2	-0.3
Falls in the last year	0.3	0.5	1.5	0.5	-0.1	0.1	-0.8	-0.7	-0.6	-1.2	-0.5	-0.9
Hair/balding pattern: Pattern 3	0.6	0.9	3.4	-0.8	-0.5	-0.5	1.9	1.0	0.8	-0.9	0.8	-0.3
Number of live births	0.5	0.7	2.9	0.5	0.6	-0.7	0.0	-1.7	1.0	-1.0	-0.3	-0.6
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	2.9	1.6	0.3	-0.8	-0.6	-1.4	-1.3	-1.7	-0.7	-1.0
Pulse rate	0.6	1.0	4.3	0.0	0.5	1.4	0.3	-0.4	0.1	1.5	-0.5	2.1
Happiness	0.5	0.6	2.6	0.0	0.2	0.7	-1.1	-1.6	0.1	-0.1	0.1	-1.0
Noisy workplace	0.4	0.4	1.5	-0.9	0.7	-0.2	-1.2	-0.7	0.7	0.2	-0.3	-0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.8	1.1	-0.8	-0.2	0.4	-0.1	-1.7	-0.5	0.4	-0.4
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	4.4	1.4	0.9	2.1	-0.6	0.7	0.6	1.2	-0.7	1.2
Mouth/teeth dental problems: Dentures	0.6	1.0	2.9	-1.3	-1.1	-1.3	0.2	1.7	-0.2	-0.5	1.0	-0.5
Asthma	0.3	0.7	3.1	-0.7	-0.8	-0.5	1.8	0.4	-0.1	0.9	0.4	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.9	1.4	-0.2	0.5	0.2	-1.1	0.1	-1.0	-0.1	-0.8
Medication: Cholesterol lowering	0.8	1.2	3.5	0.2	-1.2	-1.1	1.5	1.9	-0.6	-0.5	0.8	-0.9
Depression (self-reported)	1.7	2.0	4.3	1.6	1.5	2.1	1.0	-0.5	1.1	1.3	-1.3	1.8
Medication: Lansoprazole	1.8	2.0	6.4	0.3	1.8	1.5	-0.2	-0.6	0.8	2.2	-0.7	2.5
Prospective memory result	1.0	1.2	7.7	0.7	-0.3	0.0	2.8	0.8	0.9	-1.0	-0.1	-0.3
Lung cancer (father)	0.2	0.2	0.7	0.8	-0.2	-0.1	0.6	-0.5	0.3	0.2	-0.7	0.1
Illnesses of mother	3.6	4.5	14.7	0.8	-2.2	-2.5	-0.6	-0.3	-2.2	-3.8	0.6	-2.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	2.9	1.6	1.4	-0.2	-1.1	-1.7	-0.5	-0.6	-1.0	-0.3
Pulse wave Arterial Stiffness index	0.3	0.4	1.3	0.2	-0.5	0.1	-0.0	1.1	-0.9	-0.2	-0.6	0.7
Impedance of arm (left)	0.1	0.5	2.4	-1.6	0.8	0.3	0.4	-0.7	-0.3	0.8	-0.4	-0.0
Arm fat mass (right)	0.1	0.5	1.7	0.3	-1.3	-1.2	-0.0	0.2	-0.4	-0.6	0.3	-0.7
Trunk predicted mass	0.4	2.1	13.8	3.7	-1.1	-0.3	0.7	1.1	-0.8	-1.0	0.4	-0.5
Standing height	0.5	4.6	28.6	5.3	0.0	0.3	2.7	1.7	-1.3	0.3	-0.6	0.4
Length of working week for main job	0.8	0.9	5.3	0.0	0.3	-0.3	-2.3	-0.6	-1.2	0.1	-0.6	0.2
Exposure to tobacco smoke at home	0.4	0.5	1.6	-0.7	-0.8	-0.6	-0.6	1.3	-0.7	-0.4	0.3	-0.4
Breastfed as a baby	0.9	1.1	6.6	0.7	1.2	0.4	-0.9	-2.6	-0.2	0.0	-0.1	-0.0
Tense / ‘highly strung’	2.5	4.2	8.0	2.3	2.1	2.8	1.3	-1.4	0.2	1.7	-2.8	2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	4.0	-0.1	-0.4	1.0	2.0	-0.8	0.6	0.6	-0.1	0.8
Hair/balding pattern: Pattern 4	0.2	0.5	1.9	1.4	0.2	0.9	-0.3	-0.8	0.1	0.4	-0.4	0.5
Birth weight of first child	1.2	2.1	5.4	1.6	1.6	0.6	1.0	-0.7	1.1	1.6	-2.3	1.7
Peak expiratory flow (PEF)	1.2	2.8	12.1	1.0	-1.0	-1.8	0.1	-1.2	-1.1	-3.5	0.0	-2.3
Pulse wave reflection index	0.8	1.0	3.5	0.3	-1.2	-0.4	-1.0	-0.6	-1.9	-1.0	-0.6	-1.0
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.3	-0.1	-1.2	-0.5	0.6	0.9	-0.4	-0.4	0.5	-0.3
Loud music exposure frequency	0.3	0.3	0.9	0.6	-0.4	1.0	-0.5	0.9	0.1	-0.3	0.3	-0.2
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.3	1.8	-1.3	-0.2	0.7	0.6	-0.9	-1.4	0.3	-1.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	-0.5	-0.1	-0.7	0.4	-0.6	-0.5	-0.3	0.5	-0.7
Blood clot in the leg (DVT)	0.9	1.2	3.5	-0.8	-1.9	-1.0	0.5	1.1	-0.8	-0.9	1.5	-0.8
Medication: Paracetamol	0.5	0.8	2.3	-0.4	-1.4	-1.1	-0.5	1.0	-1.5	-0.7	0.1	0.0
Headache pain in last month	0.3	0.6	1.5	0.3	0.2	0.5	-1.0	-0.4	0.4	1.2	-1.0	0.9
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	5.9	-0.0	0.5	0.3	-2.4	-2.4	-0.7	-0.3	-0.8	0.0
Glaucoma (self-reported)	0.4	0.5	1.4	0.0	-0.5	-0.6	1.2	0.8	1.0	0.5	0.7	0.4
Gout (self-reported)	0.4	0.6	3.1	0.4	-0.7	-1.8	0.3	0.3	-0.5	-0.6	0.6	-0.5
Hypothyroidism/myxoedema (self-reported)	2.7	5.3	15.2	-2.0	-0.9	-3.9	-2.1	-2.2	-1.8	-2.4	1.4	-2.7
Medication: Amlodipine	0.7	1.0	4.3	0.3	0.6	0.3	2.1	0.5	1.2	1.0	-0.7	0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.8	3.3	-0.3	-0.2	0.4	1.2	1.8	-0.3	0.7	0.5	1.0
Birth weight	0.5	1.2	3.2	0.6	-1.0	-1.8	-0.6	-0.6	0.3	-1.5	0.7	-1.4
Chronic bronchitis/emphysema (mother)	3.0	3.5	7.1	0.3	2.3	2.7	-0.0	-1.9	1.6	2.1	-1.8	2.3
High blood pressure (siblings)	0.3	0.4	0.8	-0.6	-0.9	0.3	0.2	0.8	0.2	0.3	0.7	-0.8
Forced vital capacity (FVC), Best measure	0.3	1.2	2.7	1.6	1.5	0.2	-0.4	-1.5	-1.2	-0.1	-1.2	0.5
Body fat percentage	0.1	0.4	1.4	-0.6	-1.1	-1.2	0.3	0.5	-0.1	-0.2	0.2	-0.4
Leg fat percentage (right)	0.3	1.0	3.0	-1.0	-1.4	-1.7	-0.1	0.6	-0.3	-1.2	0.5	-0.9
Arm fat-free mass (right)	0.4	1.8	11.0	3.3	-1.0	-0.7	0.8	1.6	-0.4	-0.6	0.2	-0.4
Exposure to tobacco smoke outside home	0.3	0.4	0.9	0.9	-0.1	0.5	-0.4	0.7	-0.9	0.2	-0.8	0.9
Comparative body size at age 10	0.4	1.0	2.6	-1.3	-1.3	0.9	0.8	0.8	-0.4	0.1	1.6	-0.8
Number of full brothers	0.7	0.9	2.8	0.8	1.4	0.6	0.3	-1.7	0.7	0.4	-1.2	0.3
Worry too long after embarrassment	0.9	1.5	7.0	-0.0	0.7	1.2	2.6	-1.5	1.2	0.7	-0.7	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	4.6	0.2	-0.3	0.4	2.1	-0.7	0.5	-0.2	-0.2	-0.1
Wheeze or whistling in the chest in last year	1.4	2.5	6.6	1.3	1.6	1.2	-0.0	-0.5	1.0	2.3	-2.0	2.6
Number of children fathered	0.1	0.1	0.8	-0.1	0.0	0.2	0.9	0.1	0.3	-0.1	-0.2	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.7	0.1	0.5	-0.3	-0.1	-0.4	0.8	0.3	-0.7	0.5
Age at first live birth	0.2	0.3	1.5	-0.4	-0.4	-0.0	0.3	0.3	-0.3	0.4	0.6	1.2
Pulse wave peak to peak time	0.2	0.3	0.7	0.1	0.5	-0.1	-0.0	-0.8	0.8	0.3	0.6	-0.7
Health satisfaction	0.3	0.4	1.8	0.1	-0.0	0.2	1.3	-0.7	0.7	0.8	0.1	0.6
Shortness of breath walking on level ground	0.3	0.3	1.8	0.5	-0.0	-0.1	-0.7	-1.3	0.3	0.7	0.1	-0.1
Qualifications: College or University degree	0.3	1.1	4.8	1.1	-0.8	-0.5	0.1	-1.1	-2.2	-1.2	0.0	-0.3
Eye problems/disorders: None of the above	2.0	2.4	5.8	0.5	2.4	0.7	-1.6	-1.6	-0.3	1.0	-2.3	1.8
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.2	-1.8	-0.3	-1.3	-1.0	-0.4	0.3	-0.8	1.4	-0.9
Emphysema/chronic bronchitis	1.9	2.2	5.3	-0.9	-2.3	-1.1	1.6	0.5	-0.4	-1.8	1.2	-2.2
Medication for pain relief, constipation, heartburn	0.7	1.3	3.5	0.6	1.9	1.4	-0.9	-0.9	0.3	1.4	-0.6	1.1
Neck or shoulder pain in last month	1.3	1.8	9.0	0.3	-1.1	-0.7	3.0	-0.1	-0.1	-1.3	1.1	-1.7
Medication: Blood pressure	0.7	1.2	5.5	-0.3	-0.3	0.4	2.4	1.7	1.1	0.4	0.4	0.1
Angina (self-reported)	0.7	0.9	3.0	1.1	-0.2	0.9	1.7	-1.2	0.1	-0.6	-0.6	-1.0
Migraine (self-reported)	1.9	2.3	11.6	1.2	1.2	0.7	-3.4	-1.1	-1.7	-0.1	-1.2	0.8
Medication: Ibuprofen	0.5	0.5	2.0	0.9	0.3	1.4	0.6	-1.0	0.7	-0.1	-0.3	0.1
Medication: Allopurinol	0.4	0.6	2.5	1.6	0.6	-1.4	0.0	0.2	0.5	0.2	-0.2	-0.1
Medication: Omeprazole	1.2	1.4	3.3	0.6	1.8	0.9	0.2	-1.1	0.9	1.6	-1.0	1.7
Medication: Seretide 50 evohaler	0.9	1.1	3.1	-1.7	-1.0	-1.8	1.1	-0.4	0.7	-0.4	0.8	-0.6
Mean time to correctly identify matches	0.7	1.4	6.8	-1.4	-0.7	-0.5	-0.1	2.6	-1.0	0.1	1.3	0.3
Heart disease (mother)	0.4	0.5	3.1	-1.1	-0.4	-0.3	0.1	1.8	-0.0	0.4	0.4	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.6	-1.0	-0.5	-1.3	0.9	0.4	0.5	-0.6	0.2	-0.2
Whole body fat mass	0.1	0.5	1.5	0.8	-1.2	-1.1	0.4	0.7	-0.4	-0.3	0.1	-0.4
Leg fat mass (right)	0.2	0.8	2.3	0.7	-1.5	-1.3	0.4	0.9	-0.5	-0.8	0.4	-0.7
Arm predicted mass (right)	0.4	2.0	11.1	3.3	-1.0	-0.9	0.7	2.0	-0.3	-0.5	0.2	-0.1
Pulse rate, automated reading	0.1	0.4	1.4	1.2	-0.1	0.1	0.3	0.8	-0.5	0.5	-0.6	0.9
Alcohol intake frequency.	0.2	0.4	2.1	-0.3	-0.7	-1.5	0.3	0.7	-0.2	-0.5	0.2	-0.6
Comparative height size at age 10	0.5	2.9	15.1	3.9	-0.5	0.0	2.3	2.1	-0.9	0.5	-0.1	0.6
Number of full sisters	0.1	0.2	0.9	0.9	0.4	-0.3	-0.6	0.2	-0.0	-0.2	0.0	-0.0
Suffer from ‘nerves’	1.8	2.9	6.2	0.3	1.3	2.1	1.4	-1.2	1.6	2.5	-1.8	2.1
Overall health rating	0.2	0.4	1.0	0.2	0.0	1.0	1.0	0.4	0.7	0.4	-0.5	0.3
Chest pain or discomfort	1.5	2.2	8.5	1.5	0.7	2.9	1.5	-0.7	1.4	1.3	-0.6	1.4
Had major operations	1.3	1.5	3.4	-1.8	-1.6	-1.9	0.7	0.5	-0.5	-0.9	0.8	-1.3
Age at last live birth	0.6	0.9	2.1	0.0	-1.4	-1.1	0.8	0.7	-0.8	-1.2	1.4	-0.4
Family relationship satisfaction	1.1	1.4	4.1	-0.6	-1.1	-1.3	0.7	-1.1	-0.8	-1.6	0.6	-2.0
Leg pain on walking	0.4	0.6	1.5	-0.9	-0.6	-1.0	1.2	0.7	0.5	0.0	0.6	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.3	0.4	-1.0	0.8	-0.1	-0.8	-0.5	-0.5	0.7	-1.5
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.8	-0.5	0.1	-0.1	0.1	0.1	0.3	0.9	-0.0	-0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.7	0.4	0.3	-0.3	-0.5	0.1	-0.2	0.2	-0.8	0.4
Medication: Aspirin	1.0	1.3	2.7	-0.3	-1.4	-0.2	1.6	1.3	0.6	-1.4	0.6	-1.6
Supplements: Vitamin C	1.2	1.4	4.3	2.1	0.5	0.9	1.9	-0.2	0.4	1.0	-1.3	1.0
Knee pain experienced in last month	1.0	1.5	7.0	-2.6	-1.0	-1.2	0.5	1.5	-0.1	0.4	1.2	0.5
Hypertension (Self-reported)	0.2	0.6	3.4	0.6	0.1	1.8	0.5	0.7	-0.1	0.6	0.0	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	2.6	-0.9	1.0	1.3	-1.4	-0.7	0.6	1.6	-0.3	1.5
Illnesses of father: Heart disease	0.1	0.2	0.8	0.0	-0.5	-0.0	0.2	0.4	0.9	-0.2	0.2	-0.2
Illnesses of siblings: Diabetes	0.7	0.8	2.3	-1.3	0.2	1.0	-1.1	-0.3	0.5	1.5	0.4	0.8
Smoking status: Previous	1.4	2.0	5.5	-1.9	0.2	0.7	2.3	0.6	0.6	2.2	0.9	1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	2.5	1.0	0.2	-0.5	-0.4	-0.1	-1.6	-0.4	-0.1	-0.5
Whole body fat-free mass	0.3	1.8	12.0	3.5	-1.1	-0.5	0.5	0.8	-0.8	-1.0	0.2	-0.6
Leg fat-free mass (right)	0.2	1.2	8.1	2.9	-1.0	-0.5	0.3	0.4	-0.7	-0.4	-0.0	-0.5
Arm fat percentage (left)	0.2	0.7	2.1	-1.1	-1.3	-1.5	-0.1	0.0	-0.2	-0.7	0.5	-0.9
Average weekly red wine intake	0.8	1.2	6.9	-1.0	-0.7	-0.9	0.1	-0.2	-2.6	0.0	1.2	0.1
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.0	0.5	1.0	0.4	-0.4	-1.0	0.8	0.7	-0.5	0.5
Mood swings	0.8	1.4	9.1	0.5	0.2	0.8	-1.2	-3.0	0.4	-0.2	-0.6	-0.7
Loneliness, isolation	0.4	0.5	1.2	-0.3	-1.0	1.1	0.4	-0.9	0.8	0.1	0.1	-0.8
Long-standing illness, disability or infirmity	0.6	0.9	2.2	-0.8	-0.9	-1.0	1.1	1.5	0.8	0.1	1.0	0.7
Ever had bowel cancer screening	0.7	0.8	2.1	0.1	1.0	0.6	1.5	-0.7	0.9	0.5	-0.8	1.3
Diabetes diagnosed by doctor	1.5	2.5	7.2	0.9	-2.7	-0.1	-1.1	0.3	-2.1	-1.6	1.2	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.2	0.1	-0.7	-0.5	-0.2	-0.5	0.0	-1.1	0.3	-1.0
Friendships satisfaction	0.5	0.6	2.4	0.8	0.4	0.2	-0.9	-1.5	0.2	0.0	-1.2	0.2
Qualifications: nursing, teaching	0.3	0.5	1.6	0.9	0.2	0.3	1.3	-0.3	-0.5	0.7	-0.5	0.9
Commuting to job workplace: Walk	1.6	1.7	3.6	1.4	-1.9	-0.2	1.9	-0.2	-0.1	-1.5	1.0	-1.8
Eye problems/disorders: Cataract	1.8	2.0	5.8	0.9	-1.6	-0.1	2.4	1.7	0.4	-1.6	1.6	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.7	-0.5	-0.4	0.2	0.4	0.2	-1.3	0.2	-0.3	0.1
Medication for cholesterol	0.2	0.3	1.2	-1.1	0.5	-0.4	-0.3	-0.5	0.8	-0.3	0.4	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	3.0	0.0	-0.8	-1.7	-0.8	0.5	-1.6	-1.2	-0.5	-0.8
Back pain experienced in last month	0.6	0.9	2.0	1.4	-0.3	1.1	1.4	1.3	0.3	0.1	0.6	0.5
Mineral and other dietary supplements	1.1	1.5	5.8	0.8	0.6	1.0	-1.9	-2.4	-0.2	-0.5	-1.1	-1.0
Breast cancer (self-reported)	1.1	1.3	3.1	-1.4	0.8	0.8	-0.5	0.1	1.3	1.4	-1.1	1.8
Asthma (self-reported)	0.4	0.8	3.9	-0.7	-0.9	-0.4	2.0	0.5	0.0	1.1	0.3	0.9
Osteoporosis (self-reported)	0.7	0.9	2.0	-1.0	-1.2	-0.7	1.4	0.6	-1.4	-0.5	0.5	-0.6
Osteoarthritis (self-reported)	1.5	2.0	4.9	0.5	1.6	1.9	-0.5	0.0	0.2	2.0	-1.4	2.2
Medication: Aspirin	0.7	1.0	3.0	0.1	-1.2	0.1	1.7	1.0	0.2	-0.9	0.3	-1.4
Medication: Gliclazide	1.1	1.3	3.3	0.7	-1.1	-1.7	-0.4	0.8	-1.8	-0.9	0.6	-1.2
Illnesses of father: None of the above (group 1)	0.8	1.0	4.5	0.1	0.3	-0.1	2.1	1.1	1.7	0.4	-0.1	0.6
Smoking status: Current	0.8	1.2	4.8	2.2	1.4	1.1	-0.7	-1.2	0.2	-0.4	-0.9	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	3.0	-0.9	0.4	-0.8	-1.0	-1.7	-0.2	-0.7	-0.1	0.0
Whole body water mass	0.3	1.9	11.6	3.4	-1.2	-0.6	0.6	0.9	-0.8	-1.1	0.3	-0.6
Leg predicted mass (right)	0.2	1.2	8.2	2.9	-1.0	-0.4	0.4	0.5	-0.7	-0.4	-0.0	-0.5
Arm fat mass (left)	0.1	0.5	1.7	0.4	-1.3	-1.3	0.2	0.3	-0.3	-0.5	0.3	-0.6
Number of self-reported non-cancer illnesses	0.9	1.6	8.8	-0.1	-0.1	0.3	1.4	3.0	-0.2	0.9	0.5	1.5
Average weekly champagne plus white wine intake	0.2	0.3	1.0	0.5	0.1	-0.1	0.9	0.7	1.0	0.5	-0.2	0.1
Miserableness	0.6	1.0	6.0	0.5	-0.0	0.5	-1.0	-2.4	-1.2	-0.0	-0.4	-0.5
Guilty feelings	1.3	1.9	6.9	0.9	1.1	2.6	1.4	0.2	0.8	1.5	-0.8	1.7
Wears glasses or contact lenses	0.2	0.2	1.3	-0.1	-0.1	-0.2	1.1	0.6	0.2	0.1	-0.2	0.5
Ever taken oral contraceptive pill	0.6	0.6	3.4	1.9	-0.1	0.4	0.0	0.5	-0.7	-0.2	-1.0	0.6
Hearing aid user	1.6	1.8	3.6	-0.8	-1.4	-0.8	1.2	-0.9	1.3	-1.9	1.2	-1.9
Mother’s age at death	0.5	0.6	1.5	0.1	1.2	0.8	-0.5	-0.7	0.8	0.8	0.0	1.1
Financial situation satisfaction	0.8	1.0	2.6	0.6	1.3	0.7	-0.4	-0.9	0.9	1.1	-1.0	1.6
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.3	-0.2	-0.4	-1.1	0.5	0.2	0.1	-0.5	0.5	-0.9
Commuting to job workplace: Public transport	0.8	0.9	2.7	1.1	1.3	0.8	-0.2	0.1	-0.7	0.8	-1.2	1.7
Eye problems/disorders: Glaucoma	0.4	0.5	1.2	-0.4	-0.4	-0.8	1.0	0.4	1.1	0.3	1.0	0.2
Medication: Blood pressure	0.1	0.2	0.6	0.8	0.4	0.7	0.0	-0.1	-0.0	0.8	-0.5	0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.8	-0.3	-0.5	-0.2	-0.3	-0.2	0.0	-0.9	0.1	-0.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.0	-0.4	0.1	-0.7	1.7	1.1	0.4	0.6	-0.3	1.2
High cholesterol (Self-reported)	0.5	0.9	4.9	-0.3	-0.9	-0.2	-0.4	2.2	-0.9	-0.2	0.7	-0.5
Medication: Bendroflumethiazide	0.3	0.4	2.0	0.3	-0.7	1.4	0.3	0.3	0.0	0.8	0.3	-0.1
Medication: Paracetamol	0.4	0.6	2.3	-0.6	-1.1	-0.8	-0.0	0.6	-1.5	-0.1	-0.2	0.2
Medication: Lisinopril	1.1	1.5	5.6	1.9	1.0	2.4	-0.8	0.5	1.1	0.6	-0.7	0.7
Medication: Atorvastatin	2.1	2.5	6.4	-0.9	-1.9	-1.2	0.2	2.0	-1.6	-1.2	2.5	-1.7
Illnesses of father: High blood pressure	0.8	1.0	3.2	-1.6	-0.2	-1.3	-0.5	0.1	-1.0	0.4	1.8	-0.4
Alcohol drinker status: Never	0.8	0.9	3.0	-0.5	-0.3	-1.3	-0.8	-0.5	-1.7	-0.5	-0.1	-1.6
Ever smoked	0.6	1.0	4.2	-0.8	0.1	0.3	2.0	1.2	0.3	0.6	1.1	1.2
Basal metabolic rate	0.3	1.6	9.8	3.1	-1.1	-0.7	0.4	0.8	-0.8	-0.9	0.2	-0.6
Leg fat percentage (left)	0.2	0.9	2.8	-0.8	-1.4	-1.7	-0.1	0.7	-0.3	-0.9	0.5	-0.8
Arm fat-free mass (left)	0.3	1.6	11.0	3.3	-0.9	-0.4	0.4	1.1	-0.7	-0.5	0.2	-0.1
Number of operations (self-reported)	0.3	0.4	2.4	-1.6	-0.3	-0.7	0.1	-0.0	0.2	0.6	0.6	0.1
Average weekly beer plus cider intake	0.3	0.5	2.2	1.5	0.2	0.7	-0.5	-0.1	-0.2	-0.4	-1.1	-0.3
Irritability	0.2	0.4	1.0	1.0	0.0	0.8	0.2	-0.6	0.4	1.0	-0.4	0.2
Risk taking	0.7	1.0	2.5	0.1	-0.2	-1.5	-0.2	-1.6	0.7	-1.3	0.3	-1.4
Ever had prostate specific antigen (PSA) test	1.8	2.1	6.5	-0.8	-1.9	-0.8	2.5	0.4	-1.3	-1.5	1.3	-1.1
Fractured/broken bones in last 5 years	1.1	1.4	4.0	-1.1	-0.9	-2.0	-1.2	1.7	-0.9	-0.6	1.0	-0.1
Age started oral contraceptive pill	2.7	3.3	8.6	0.4	2.3	1.9	-0.3	1.2	1.4	2.4	-1.7	2.9
Diastolic blood pressure, automated reading	0.3	1.0	2.0	1.4	0.4	1.0	0.2	1.1	-0.9	0.9	-1.4	0.9
Ever depressed for a whole week	0.4	0.5	3.6	0.6	-0.1	-0.0	1.9	0.3	0.1	-0.3	-0.0	0.1
Unable to work because of sickness or disability	1.0	1.3	5.6	-1.1	-2.4	-0.7	0.7	-0.6	-0.5	-0.8	0.9	-1.4
Commuting to job workplace: Cycle	1.0	1.2	3.0	-1.0	-1.6	-1.7	0.7	-0.3	-0.5	-0.9	1.2	-1.1
Myopia	0.5	0.8	3.5	0.6	-0.5	-0.0	1.9	1.4	0.4	0.6	0.6	0.4
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.9	-1.0	0.0	-1.7	-1.0	-0.9	0.4	-0.6	-0.0	-0.4
Cholesterol lowering medication	0.8	1.2	2.5	-0.4	-1.2	-0.6	-1.1	1.6	-1.0	-1.2	0.7	-1.3
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	3.4	0.3	1.8	0.7	0.3	-1.3	1.2	1.9	-1.1	1.4
Pain experienced in last month	0.2	0.3	0.7	0.2	0.7	0.1	-0.2	-0.7	0.8	-0.2	-0.7	-0.2
Supplements: Calcium	1.2	1.4	5.2	0.2	0.2	2.3	-0.9	-1.2	-1.3	1.2	-0.4	1.1
Basal cell carcinoma (self-reported)	0.9	1.0	3.5	-0.1	-0.6	-1.6	-0.2	-1.2	-1.9	-0.5	0.7	-0.8
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.8	-0.6	-0.3	-0.2	-0.5	0.8	0.4	-0.6	0.9	0.0
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	3.7	-0.6	-1.9	-1.0	0.8	0.9	-1.0	-0.9	1.4	-0.8
Heart disease (siblings)	2.2	2.7	5.9	1.9	1.7	0.7	0.9	0.9	2.4	1.4	-1.7	2.3
Alcohol drinker status: Previous	0.9	1.0	4.0	-0.8	-0.8	-0.3	1.5	2.0	0.8	-0.8	0.6	0.1
Pack years of smoking	3.4	4.9	8.7	-2.2	-2.8	-2.2	0.9	1.8	-1.9	-2.3	3.0	-2.3
Impedance of whole body	0.1	0.4	1.7	-1.3	0.8	0.2	0.6	-0.0	-0.4	0.9	-0.3	0.2
Leg fat mass (left)	0.2	0.7	2.3	0.7	-1.5	-1.2	0.4	1.0	-0.5	-0.7	0.3	-0.6
Arm predicted mass (left)	0.3	1.5	8.9	3.0	-1.2	-0.7	0.4	1.1	-0.9	-0.7	0.4	-0.5