Hub : Genes

EXTL1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Breast Invasive Carcinoma 0.0165 0.0084 2.4e-05 0.020 0.023 0.017 NA 0.016 4.6e-05 1.5e-05 0.00019 NA 0.00020
2 TCGA Colon Adenocarcinoma 0.0920 0.0710 2.9e-03 0.012 0.026 0.022 NA 0.013 6.3e-02 1.2e-02 0.02000 NA 0.05400
3 TCGA Rectum Adenocarcinoma 0.1420 0.0810 5.1e-03 0.027 0.054 0.052 NA 0.029 7.7e-02 2.2e-02 0.02300 NA 0.06900
4 TCGA Thyroid Carcinoma 0.0980 0.0560 1.1e-03 0.036 0.032 0.018 NA 0.030 1.9e-04 4.1e-04 0.00690 NA 0.00057

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 4.3 6.8 9.6 2.9 1.8 3.1 -2.4
Bipolar Disorder or Schizophrenia 1.7 4.2 7.4 2.2 0.8 2.7 -2.0
Depressed Affect (Nagel 2018) 2.4 5.0 7.2 2.6 2.1 2.7 -1.3
Depression (Nagel 2018) 0.4 0.6 0.8 0.9 0.7 0.9 -0.4
Intelligence (Savage-Jansen 2018) 1.2 3.8 4.4 2.1 2.0 2.0 -1.6
Neuroticism (Nagel 2018) 0.0 0.0 0.1 -0.2 -0.1 -0.2 0.3
Schizophrenia (2018) 0.3 0.6 1.1 0.6 -0.3 1.1 -0.8
Schizophrenia vs Biploar Disorder 2.5 3.3 6.5 -2.2 -0.9 -2.5 1.1
Worry (Nagel 2018) 1.0 2.2 3.9 -1.7 -1.1 -2.0 0.9
Alzheimer’s Disease (in mother) 0.1 0.1 0.3 -0.4 -0.2 -0.5 -0.2
Alzheimer’s Disease (in father) 0.2 0.2 0.4 -0.3 0.6 -0.5 0.4
Alzheimer’s Disease (including proxy) 0.1 0.2 0.4 0.3 0.2 0.4 -0.6
Crohns Disease (2017) 1.0 2.1 3.0 -1.7 -1.5 -1.6 0.8
Irritable Bowel Disease (IBD) 0.2 0.5 1.3 -0.7 -0.4 -0.5 1.1
Ulcerative Colitis (UC) 0.2 0.4 1.2 0.3 0.4 0.4 1.1
Major Depression (MDD) 0.4 0.5 0.8 0.7 0.9 0.7 -0.3
Reaction Time 0.2 0.5 0.6 -0.8 -0.8 -0.6 0.6
Verbal and Numeric Reasoning (VNR) 0.5 1.1 1.7 1.1 1.3 0.9 -0.9
Breast Cancer 0.3 0.8 1.1 1.1 1.0 1.0 0.5
Ovarian Cancer 0.9 1.2 2.6 1.1 0.8 1.6 -0.7
Prostate Cancer 0.1 0.1 0.3 0.1 0.1 -0.1 -0.6
Age at First Birth 1.1 1.6 2.5 -1.3 -1.6 -1.2 1.0
Bipolar Disorder (2011) 2.0 2.0 3.0 1.5 0.6 1.7 -1.6
Body Mass Index (BMI) (2010) 3.3 4.6 8.0 -2.1 -1.6 -1.9 2.8
Coronary Artery Disease (CAD) 1.4 1.7 4.5 1.1 0.2 1.1 -2.1
Crohns Disease (2012) 0.9 1.4 3.3 -1.2 -1.8 -0.8 -0.3
Mean Putamen Volume 2.4 2.8 3.8 -1.9 -1.5 -2.0 1.2
Fasting Glucose 0.0 0.1 0.2 -0.1 0.4 -0.2 -0.1
HbA1C 1.8 2.0 3.6 1.7 1.1 1.9 -0.6
HDL Cholesterol 0.9 1.4 2.7 -1.3 -1.6 -1.1 0.4
LDL Cholesterol 1.1 1.8 3.1 1.3 1.1 1.1 -1.8
Lupus 0.2 0.3 0.6 0.0 -0.7 0.2 -0.8
Neuroticism (2016) 0.1 0.2 0.3 0.3 0.5 0.3 0.5
Primary Biliary Cirrhosis 0.7 1.0 1.6 0.9 0.0 1.2 -1.3
Rheumatoid Arthritis 0.4 0.5 1.4 0.5 -0.5 1.2 0.2
Schizophrenia (2014) 0.2 0.4 0.7 -0.6 -0.9 -0.5 -0.4
Triglycerides 1.5 2.5 4.4 1.8 2.1 1.5 -0.1
Type 2 Diabetes (T2D) (2012) 3.0 3.4 5.7 2.0 2.4 1.9 0.5
Ulcerative Colitis 1.5 2.1 4.2 1.6 1.2 2.1 -0.3
Blood Eosinophil Count 1.5 11.6 20.1 4.1 2.6 4.5 -1.5
Blood Platelet Count 0.4 4.9 9.7 2.2 3.1 2.2 0.4
Blood Red Count 0.5 4.5 7.5 2.4 2.7 2.2 0.0
Blood White Count 0.2 1.2 2.5 -0.7 0.6 -1.1 1.6
Heel T-Score 0.3 2.7 3.7 -1.9 -0.7 -1.9 1.7
BMI 0.3 1.8 7.0 -0.4 -0.3 0.0 2.6
Height 2.0 37.9 64.8 -7.1 -3.6 -8.1 4.8
Waist Hip Ratio (WHR) 2.7 12.1 17.0 4.0 3.5 4.1 -1.8
Systolic Blood Pressure 0.1 0.5 0.9 -0.9 -0.5 -0.9 0.2
Smoking Status 1.4 3.3 5.5 1.8 1.3 1.6 -2.3
Allergy or Eczema 0.2 0.6 1.0 -0.7 -0.6 -0.6 1.0
Cardiovascular Disease 0.2 0.6 1.5 0.2 0.9 0.3 1.2
Hypothyroidism (self reported) 1.4 3.2 4.7 2.1 2.2 1.9 -0.6
Respiratory disease 0.2 0.5 1.9 -0.2 -0.3 0.2 1.4
Type 2 Diabetes (T2D) (2018) 8.1 15.2 22.6 4.5 3.5 4.8 -2.5
Lung FEV1/FVC ratio 1.1 5.6 8.0 -2.6 -2.0 -2.8 1.9
Lung FVC 2.7 13.6 15.8 -4.0 -2.7 -3.9 4.0
Neuroticism 0.1 0.2 0.3 -0.3 0.1 -0.4 0.5
Chronotype (morning person) 0.2 0.4 1.0 -0.5 -0.3 -0.7 -1.0
Hair Pigment 0.1 2.5 3.8 1.9 0.9 2.0 -1.4
Tanning 0.2 2.0 3.6 1.6 1.1 1.9 -0.8
Hand grip strength (left) 3.7 9.8 13.2 -3.5 -2.8 -3.6 2.3
Number of treatments/medications taken 0.7 1.2 1.8 -1.1 -0.2 -1.3 1.3
Average weekly spirits intake 0.4 0.5 1.0 0.6 1.0 0.6 -0.5
Sensitivity / hurt feelings 0.2 0.3 0.7 0.4 -0.3 0.8 0.5
Frequency of depressed mood in last 2 weeks 1.5 2.1 3.0 1.7 1.5 1.6 -0.9
Hearing difficulty/problems: Yes 0.2 0.3 0.5 0.4 -0.4 0.6 -0.7
Relative age of first facial hair 0.1 0.1 0.5 0.1 0.3 0.2 0.7
Other serious medical condition/disability diagnosed by doctor 2.2 2.9 3.6 -1.8 -1.2 -1.9 1.8
Ever used hormone-replacement therapy (HRT) 1.3 1.6 2.4 1.4 1.4 1.6 -0.4
Ever had hysterectomy (womb removed) 2.2 2.5 5.9 1.9 0.6 2.4 0.5
Systolic blood pressure, automated reading 1.1 3.1 4.0 -2.0 -1.5 -1.8 1.7
Eye problems/disorders: Diabetes related eye disease 5.7 6.3 7.6 2.7 1.8 2.8 -2.7
Angina 1.0 1.4 2.0 1.2 0.5 1.4 -1.4
Medication for hormone replacement therapy 0.1 0.1 0.2 -0.2 -0.5 0.0 -0.5
Vitamin and mineral supplements 6.3 8.5 11.6 3.3 2.1 3.4 -2.6
Supplements: Zinc 0.6 0.6 2.3 0.0 -0.3 0.1 -1.5
Medication: Co-codamol 0.3 0.4 0.8 -0.7 -0.3 -0.9 0.0
Medication: Metformin 4.6 6.4 9.2 2.9 2.3 3.0 -1.7
Diabetes (father) 1.9 2.4 3.8 1.5 0.9 1.6 -2.0
Diabetes (mother) 6.5 8.3 10.5 3.2 3.1 3.2 -1.8
Severe depression (siblings) 1.9 2.2 5.0 1.4 2.2 1.2 0.6
Pack years adult smoking proportion 0.9 1.3 3.1 0.9 0.9 0.7 -1.8
Impedance of leg (right) 0.7 3.3 4.2 2.0 1.2 2.0 -1.9
Leg fat-free mass (left) 1.5 8.2 12.2 -3.1 -1.1 -3.5 3.1
Trunk fat percentage 0.2 0.9 1.2 0.8 1.1 1.0 1.0
Hand grip strength (right) 2.3 6.3 7.4 -2.7 -2.0 -2.7 2.5
Townsend deprivation index at recruitment 3.4 4.7 6.7 2.5 2.2 2.6 -0.9
Current tobacco smoking 0.9 1.5 1.8 1.4 1.0 1.4 -1.1
Average weekly fortified wine intake 1.2 1.4 2.1 -1.4 -0.6 -1.5 1.1
Maternal smoking around birth 8.1 11.8 14.2 3.8 2.6 3.8 -3.5
Fed-up feelings 3.7 6.7 9.7 3.1 2.8 2.9 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.3 0.5 0.6 0.4 -0.2
Relative age voice broke 0.4 0.7 2.3 0.6 1.5 0.1 0.1
Taking other prescription medications 0.5 0.8 1.4 -0.0 1.2 -0.6 1.2
Age when periods started (menarche) 0.6 1.4 1.5 -1.2 -1.2 -1.2 1.0
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 1.8 1.2 1.3 1.3 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 2.0 0.2 0.9 0.1 1.4
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 1.5 -0.1 1.2 -0.6 0.9
Qualifications: CSEs or equivalent 0.7 0.9 1.3 1.0 0.4 0.9 -1.2
Serious illness, injury or assault to yourself 1.5 1.9 3.0 -1.5 -1.4 -1.7 0.4
High blood pressure 0.1 0.3 0.8 -0.2 0.7 -0.3 0.9
Hayfever, allergic rhinitis or eczema 0.1 0.1 0.3 -0.0 -0.4 0.3 0.5
Multivitamins +/- minerals 3.5 4.4 6.5 -2.5 -1.5 -2.6 1.7
Stomach or abdominal pain in last month 0.8 0.9 2.5 -0.7 -0.7 -0.6 1.6
Supplements: Glucosamine 4.3 5.6 6.5 -2.6 -2.3 -2.5 2.0
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 3.4 0.9 1.8 0.7 0.8
Medication: Atenolol 0.5 0.6 0.9 0.7 0.6 0.8 -1.0
Medication: Levothyroxine sodium 0.3 0.5 0.8 0.9 0.7 0.9 0.1
Sitting height 3.0 21.5 44.0 -5.2 -1.3 -6.6 3.6
Chronic bronchitis/emphysema (father) 0.4 0.5 0.8 0.7 0.8 0.9 0.3
High blood pressure (mother) 0.2 0.3 0.8 -0.5 0.2 -0.9 0.3
Body mass index (BMI) 0.1 0.5 1.1 0.4 0.5 0.5 1.1
Impedance of leg (left) 0.7 3.4 4.9 2.1 1.3 2.2 -1.6
Leg predicted mass (left) 1.6 8.2 12.6 -3.1 -1.1 -3.5 3.1
Trunk fat mass 0.2 1.0 3.3 -0.5 0.4 -0.4 1.8
Waist circumference 0.3 1.1 1.7 1.0 1.3 1.1 0.7
Number of incorrect matches in round 0.4 0.7 1.4 -0.8 -1.2 -0.6 0.8
Past tobacco smoking 2.3 4.2 8.7 -2.0 -0.8 -1.9 3.0
Alcohol usually taken with meals 5.1 8.2 15.1 -3.3 -2.2 -3.9 1.4
Nervous feelings 0.9 1.7 3.4 -1.5 -1.0 -1.9 0.5
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.0 3.5 1.6 1.9 1.4 0.1
Hearing difficulty/problems with background noise 0.7 1.2 2.7 0.9 0.7 0.8 -1.6
Hair/balding pattern: Pattern 2 0.4 0.5 0.9 0.7 0.9 0.7 0.3
Had menopause 0.2 0.3 0.6 0.3 -0.7 0.8 0.1
Had other major operations 1.5 1.8 4.2 1.0 1.3 0.4 -2.0
Forced vital capacity (FVC) 2.8 10.7 16.8 -3.5 -1.4 -4.1 3.4
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 5.0 -1.1 -0.4 -1.0 2.2
Ever unenthusiastic/disinterested for a whole week 1.4 1.7 5.3 0.7 2.3 0.1 1.0
Qualifications: None of the above 0.2 0.5 1.5 0.4 -0.3 0.5 -1.2
Financial difficulties in last 2 years 0.0 0.0 0.1 0.1 0.3 -0.0 -0.0
Mouth/teeth dental problems 0.4 0.7 1.2 -0.8 -0.2 -0.9 1.1
Heart attack 2.4 3.0 6.8 1.5 1.2 1.3 -2.6
Allergy 0.3 0.7 1.7 0.3 0.9 -0.2 -1.3
Pain all over the body in last month 0.0 0.0 0.0 -0.1 -0.2 -0.1 0.1
Diabetes (self-reported) 3.6 5.5 8.1 2.5 1.8 2.9 -2.0
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.7 -0.8 -0.7 -0.8 0.5
Medication: Ramipril 1.6 2.0 3.1 1.6 1.4 1.8 -0.6
Medication: Simvastatin 0.2 0.3 0.4 0.5 0.5 0.5 -0.6
Fluid intelligence score 1.1 2.3 3.1 1.7 1.8 1.6 -0.7
Illnesses of siblings 1.6 2.3 3.8 1.4 0.4 1.8 -2.0
Neuroticism score 0.2 0.4 0.6 0.7 0.8 0.7 0.4
Weight 0.7 3.5 5.9 -1.8 -0.4 -2.1 2.4
Impedance of arm (right) 0.8 3.8 6.1 1.9 0.7 2.3 -2.5
Arm fat percentage (right) 0.2 0.8 1.9 1.0 0.7 1.4 0.0
Trunk fat-free mass 2.7 15.6 25.8 -4.5 -2.2 -5.1 3.5
Hip circumference 0.4 1.6 3.8 -1.1 -0.1 -1.2 2.0
Time employed in main current job 0.7 0.8 1.8 0.7 -0.0 0.9 -1.3
Alcohol intake versus 10 years previously 0.7 1.0 1.8 0.7 1.4 0.5 1.3
Father’s age at death 0.3 0.5 1.4 -0.6 0.3 -1.2 0.1
Worrier / anxious feelings 2.6 4.8 7.8 -2.6 -1.8 -2.8 1.2
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.3 3.8 1.9 1.4 1.8 -0.7
Falls in the last year 0.1 0.2 0.4 0.3 0.6 0.2 0.3
Hair/balding pattern: Pattern 3 1.0 1.5 4.0 -0.7 -0.9 -0.8 -2.0
Number of live births 2.9 4.1 6.4 2.4 1.3 2.5 -1.6
Forced expiratory volume in 1-second (FEV1) 4.4 14.7 21.0 -4.1 -1.8 -4.6 4.2
Pulse rate 3.5 5.8 6.9 2.6 2.0 2.4 -2.6
Happiness 0.1 0.1 0.1 -0.3 -0.0 -0.3 0.4
Noisy workplace 1.0 1.2 3.3 0.9 1.8 0.7 -0.4
Qualifications: A levels/AS levels or equivalent 0.8 1.7 3.4 -1.3 -0.6 -1.2 1.9
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.5 0.2 0.5 0.3 0.7
Mouth/teeth dental problems: Dentures 1.3 2.2 4.2 1.7 0.9 2.0 -1.1
Asthma 0.4 0.9 2.6 -0.3 -0.9 0.3 1.6
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.7 -0.2 0.6 -0.7 1.3
Medication: Cholesterol lowering 0.2 0.3 0.5 0.5 0.0 0.7 -0.7
Depression (self-reported) 0.2 0.2 0.4 0.3 0.6 -0.1 -0.6
Medication: Lansoprazole 0.5 0.6 2.1 -0.4 0.2 -0.2 1.4
Prospective memory result 2.2 2.7 5.3 -1.7 -2.3 -1.6 -0.1
Lung cancer (father) 0.2 0.2 0.4 0.5 0.1 0.6 -0.2
Illnesses of mother 3.6 4.5 8.4 -1.9 -1.9 -1.4 2.9
Forced expiratory volume in 1-second (FEV1), Best measure 5.6 17.9 24.5 -4.6 -2.8 -4.9 4.2
Pulse wave Arterial Stiffness index 0.3 0.4 0.8 0.7 0.4 0.9 0.0
Impedance of arm (left) 0.6 2.7 3.8 1.7 0.9 1.9 -1.8
Arm fat mass (right) 0.1 0.6 1.9 -0.5 -0.0 -0.3 1.4
Trunk predicted mass 2.7 15.4 25.4 -4.4 -2.1 -5.0 3.4
Standing height 1.9 18.6 34.6 -5.0 -2.2 -5.9 3.1
Length of working week for main job 0.3 0.4 1.0 -0.4 -1.0 -0.1 -0.5
Exposure to tobacco smoke at home 0.7 0.8 1.3 0.9 0.4 1.2 -0.9
Breastfed as a baby 1.0 1.2 2.0 -1.2 -1.4 -1.2 -0.2
Tense / ‘highly strung’ 0.3 0.6 0.9 0.9 1.0 0.7 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 1.2 -0.5 0.8 -1.1 1.0
Hair/balding pattern: Pattern 4 1.4 3.4 5.6 2.1 1.1 2.4 -1.6
Birth weight of first child 1.1 2.1 2.4 -1.5 -1.3 -1.4 1.6
Peak expiratory flow (PEF) 3.2 7.3 11.2 -2.7 -1.2 -3.0 3.3
Pulse wave reflection index 0.3 0.3 0.9 0.6 -0.2 1.0 -0.2
Ever highly irritable/argumentative for 2 days 3.1 3.8 4.5 2.0 2.1 1.6 -2.0
Loud music exposure frequency 1.0 1.1 2.5 1.2 0.6 1.6 -0.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.7 -0.4 -0.1 -0.2 1.3
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 3.5 1.0 0.4 0.9 -1.9
Blood clot in the leg (DVT) 0.8 1.1 1.4 -1.2 -1.1 -1.0 0.9
Medication: Paracetamol 0.3 0.5 1.4 0.2 1.2 -0.4 0.8
Headache pain in last month 0.2 0.3 0.6 0.1 0.8 -0.2 0.7
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.5 -0.2 -0.3 -0.1 0.7
Glaucoma (self-reported) 0.3 0.4 1.4 -0.1 -0.4 -0.2 -1.2
Gout (self-reported) 2.0 2.7 3.7 1.8 1.7 1.9 -0.9
Hypothyroidism/myxoedema (self-reported) 1.3 2.5 4.2 1.9 2.0 1.5 -0.5
Medication: Amlodipine 0.3 0.4 1.2 -0.0 1.1 -0.5 -0.6
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.7 0.6 0.5 0.8 0.8
Birth weight 1.7 3.6 5.0 -2.2 -1.9 -2.2 1.1
Chronic bronchitis/emphysema (mother) 11.4 13.3 16.0 4.0 3.2 3.8 -3.5
High blood pressure (siblings) 3.7 5.4 8.1 -2.4 -1.4 -2.4 2.8
Forced vital capacity (FVC), Best measure 5.0 18.1 27.1 -4.7 -2.6 -5.2 4.0
Body fat percentage 0.3 1.2 1.7 1.1 1.2 1.3 0.6
Leg fat percentage (right) 0.3 1.2 2.2 1.2 1.0 1.5 0.1
Arm fat-free mass (right) 2.3 11.8 17.2 -3.6 -1.3 -4.2 3.9
Exposure to tobacco smoke outside home 0.4 0.6 1.0 0.6 -0.3 1.0 -0.9
Comparative body size at age 10 1.0 2.8 6.0 -1.7 -2.4 -1.5 -0.0
Number of full brothers 1.6 2.0 3.1 1.7 1.0 1.8 -1.0
Worry too long after embarrassment 3.4 5.6 8.4 -2.7 -1.7 -2.9 1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 2.1 0.8 1.4 0.3 -0.3
Wheeze or whistling in the chest in last year 0.4 0.7 1.1 0.9 0.9 1.0 0.2
Number of children fathered 0.2 0.2 0.4 -0.6 -0.6 -0.4 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 1.0 -0.1 -0.0 -0.1 -1.0
Age at first live birth 0.8 1.5 3.2 -1.3 -0.9 -1.8 -0.4
Pulse wave peak to peak time 0.7 0.8 1.8 -1.1 -0.5 -1.3 0.3
Health satisfaction 0.3 0.3 1.1 0.2 1.1 -0.3 0.0
Shortness of breath walking on level ground 0.3 0.4 1.0 0.4 1.0 -0.1 -0.5
Qualifications: College or University degree 1.8 5.5 8.1 -2.5 -0.7 -2.9 2.7
Eye problems/disorders: None of the above 1.2 1.4 1.7 -1.2 -1.0 -1.1 1.3
Mouth/teeth dental problems: Loose teeth 1.7 2.0 3.5 1.5 1.9 1.2 -1.1
Emphysema/chronic bronchitis 0.5 0.6 1.5 0.6 -0.0 0.7 -1.2
Medication for pain relief, constipation, heartburn 0.3 0.5 1.4 -0.6 -1.2 -0.2 0.1
Neck or shoulder pain in last month 0.7 0.9 2.5 1.0 1.6 0.5 -0.2
Medication: Blood pressure 0.3 0.6 1.1 0.6 1.0 0.4 -0.9
Angina (self-reported) 1.1 1.4 2.3 1.1 0.5 1.3 -1.5
Migraine (self-reported) 0.4 0.5 1.5 0.7 1.2 0.4 -0.2
Medication: Ibuprofen 0.8 0.9 2.2 0.0 1.1 -0.5 1.5
Medication: Allopurinol 2.3 3.1 4.4 1.9 2.1 2.0 -0.2
Medication: Omeprazole 1.9 2.3 3.2 1.8 1.5 1.5 -1.3
Medication: Seretide 50 evohaler 3.6 4.2 5.5 -2.3 -2.3 -1.9 1.5
Mean time to correctly identify matches 0.3 0.6 1.1 -0.9 -1.1 -0.6 0.5
Heart disease (mother) 1.6 2.0 4.3 1.4 2.1 0.9 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.7 2.1 3.6 -1.5 -1.9 -1.4 0.7
Whole body fat mass 0.1 0.6 2.1 -0.1 0.6 -0.0 1.5
Leg fat mass (right) 0.1 0.4 1.1 0.2 0.7 0.3 1.1
Arm predicted mass (right) 2.0 10.3 14.7 -3.3 -1.0 -3.8 3.8
Pulse rate, automated reading 6.5 21.1 24.3 4.9 4.1 4.4 -4.9
Alcohol intake frequency. 0.7 1.7 6.0 -0.2 0.8 -0.2 2.4
Comparative height size at age 10 2.4 13.4 20.8 -4.3 -2.5 -4.6 2.8
Number of full sisters 0.7 0.9 1.7 1.1 0.5 1.3 0.6
Suffer from ‘nerves’ 0.4 0.6 1.2 0.8 0.4 0.7 -1.1
Overall health rating 0.4 0.9 2.2 0.9 1.5 0.7 -0.0
Chest pain or discomfort 0.2 0.2 0.4 0.4 -0.4 0.5 -0.7
Had major operations 0.3 0.4 0.5 0.7 0.7 0.6 -0.4
Age at last live birth 0.5 0.8 1.3 -0.7 -0.6 -1.2 -1.0
Family relationship satisfaction 2.0 2.5 3.1 1.5 1.6 1.4 -1.8
Leg pain on walking 0.2 0.2 0.5 -0.1 0.2 -0.6 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 2.1 -0.8 -0.7 -0.6 1.5
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.5 0.4 -0.3 0.7 -0.4
Illness, injury, bereavement, stress in last 2 years 3.8 4.7 5.6 2.4 1.7 2.3 -2.2
Medication: Aspirin 0.8 1.0 2.8 0.7 0.4 0.8 -1.7
Supplements: Vitamin C 6.5 7.6 11.5 -3.2 -2.1 -3.4 2.1
Knee pain experienced in last month 0.5 0.7 1.9 0.8 1.4 0.4 -0.4
Hypertension (Self-reported) 0.2 0.4 1.0 -0.5 0.3 -0.6 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.4 -0.3 0.5 -0.6 0.4
Illnesses of father: Heart disease 0.2 0.3 0.7 0.2 0.8 -0.3 -0.6
Illnesses of siblings: Diabetes 1.2 1.5 2.8 1.4 1.2 1.7 0.3
Smoking status: Previous 2.0 3.0 5.7 1.7 0.6 1.8 -2.4
Forced expiratory volume in 1-second (FEV1), predicted 2.1 4.3 8.4 -2.4 -1.7 -2.9 0.4
Whole body fat-free mass 2.2 12.6 20.3 -3.9 -1.7 -4.5 3.4
Leg fat-free mass (right) 1.6 8.6 12.5 -3.1 -1.1 -3.5 3.3
Arm fat percentage (left) 0.3 1.0 2.0 1.1 0.9 1.4 0.3
Average weekly red wine intake 0.3 0.5 0.7 -0.8 -0.9 -0.7 -0.1
Handedness (chirality/laterality): Left-handed 1.6 2.0 3.0 -1.5 -1.7 -1.6 -0.3
Mood swings 0.3 0.5 1.1 0.9 0.5 1.1 -0.1
Loneliness, isolation 0.9 1.3 1.8 1.2 1.4 1.2 -0.6
Long-standing illness, disability or infirmity 0.3 0.4 0.8 0.6 0.7 0.3 -0.9
Ever had bowel cancer screening 0.1 0.1 0.2 -0.2 -0.1 -0.4 -0.3
Diabetes diagnosed by doctor 5.2 8.6 13.0 3.3 2.5 3.6 -2.2
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 0.7 0.7 0.9 0.3 -0.8
Friendships satisfaction 0.5 0.6 1.1 0.9 0.7 1.0 -0.4
Qualifications: nursing, teaching 1.5 2.3 5.4 -1.4 -0.8 -1.2 2.3
Commuting to job workplace: Walk 0.8 0.9 1.5 -1.1 -0.6 -1.2 0.5
Eye problems/disorders: Cataract 2.2 2.5 3.1 1.7 1.5 1.8 -1.4
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 0.7 -0.6 -0.8 -0.3 0.7
Medication for cholesterol 0.1 0.1 0.2 0.4 0.3 0.2 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 7.3 8.6 10.5 3.2 3.2 3.0 -2.1
Back pain experienced in last month 0.5 0.7 1.1 1.0 0.6 0.9 -0.9
Mineral and other dietary supplements 5.9 8.0 12.2 3.3 2.2 3.5 -1.9
Breast cancer (self-reported) 0.2 0.2 0.5 -0.5 -0.3 -0.7 0.2
Asthma (self-reported) 0.8 1.5 4.3 -0.7 -1.2 -0.1 2.1
Osteoporosis (self-reported) 1.0 1.2 2.6 -0.3 -1.5 -0.0 -1.6
Osteoarthritis (self-reported) 0.4 0.6 1.1 0.7 0.6 0.5 -1.0
Medication: Aspirin 0.8 1.0 2.4 0.8 0.3 0.9 -1.6
Medication: Gliclazide 3.2 3.6 5.1 2.2 1.7 2.3 -1.2
Illnesses of father: None of the above (group 1) 0.1 0.2 0.5 -0.2 -0.7 0.0 0.4
Smoking status: Current 0.6 0.9 1.0 1.0 0.8 0.9 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 6.0 12.7 15.1 -3.9 -3.0 -3.9 3.4
Whole body water mass 2.2 12.7 20.9 -4.0 -1.6 -4.6 3.4
Leg predicted mass (right) 1.6 8.4 12.2 -3.1 -1.1 -3.5 3.3
Arm fat mass (left) 0.1 0.5 1.7 -0.2 0.3 -0.1 1.3
Number of self-reported non-cancer illnesses 0.2 0.4 1.0 0.5 1.0 0.1 -0.6
Average weekly champagne plus white wine intake 1.0 1.4 1.6 1.2 1.2 1.0 -1.3
Miserableness 2.2 3.8 6.0 2.3 1.9 2.5 -0.6
Guilty feelings 0.9 1.3 1.7 -1.3 -1.3 -1.2 0.6
Wears glasses or contact lenses 0.5 0.6 1.3 -0.6 0.2 -1.1 0.9
Ever taken oral contraceptive pill 5.3 5.9 9.4 2.6 3.1 2.4 -1.3
Hearing aid user 1.3 1.4 3.2 1.0 0.3 1.2 -1.8
Mother’s age at death 2.1 2.7 4.8 -2.0 -1.2 -2.2 0.8
Financial situation satisfaction 1.2 1.4 3.3 1.1 1.8 0.7 -0.9
Tinnitus: Yes, now most or all of the time 2.6 3.0 5.5 -2.0 -1.3 -2.4 0.8
Commuting to job workplace: Public transport 0.3 0.4 0.7 -0.3 0.7 -0.6 0.8
Eye problems/disorders: Glaucoma 0.2 0.3 0.6 0.5 -0.0 0.6 -0.8
Medication: Blood pressure 0.2 0.3 0.6 -0.7 -0.8 -0.4 0.4
Pain type(s) experienced in last month: Hip pain 0.6 0.8 2.3 -0.2 0.7 -0.4 1.5
Supplements: Fish oil (including cod liver oil) 5.0 6.5 8.1 -2.9 -1.8 -2.8 2.6
High cholesterol (Self-reported) 4.4 7.8 10.8 3.1 2.4 3.3 -2.3
Medication: Bendroflumethiazide 0.1 0.1 0.3 0.3 -0.1 0.6 0.3
Medication: Paracetamol 0.5 0.8 1.7 0.1 1.3 -0.5 1.1
Medication: Lisinopril 0.3 0.4 0.9 -0.6 -1.0 -0.6 -0.2
Medication: Atorvastatin 1.3 1.5 2.4 1.4 1.2 1.6 -0.5
Illnesses of father: High blood pressure 0.1 0.2 0.5 -0.1 0.1 -0.2 0.7
Alcohol drinker status: Never 0.0 0.0 0.1 -0.0 0.3 0.0 0.3
Ever smoked 0.5 0.9 1.8 0.9 0.7 0.7 -1.3
Basal metabolic rate 1.8 10.2 15.7 -3.5 -1.3 -4.0 3.4
Leg fat percentage (left) 0.4 1.4 2.7 1.3 1.0 1.6 0.2
Arm fat-free mass (left) 2.0 10.3 15.8 -3.5 -1.3 -4.0 3.4
Number of operations (self-reported) 0.1 0.2 0.6 0.1 0.2 -0.3 -0.8
Average weekly beer plus cider intake 3.9 5.7 9.1 2.8 1.9 3.0 -1.6
Irritability 2.1 3.6 5.1 2.1 1.3 2.3 -1.8
Risk taking 0.1 0.2 0.2 -0.5 -0.5 -0.4 0.3
Ever had prostate specific antigen (PSA) test 2.0 2.3 4.8 -1.8 -0.6 -2.2 0.7
Fractured/broken bones in last 5 years 0.4 0.5 1.6 0.6 0.0 0.5 -1.3
Age started oral contraceptive pill 0.5 0.7 1.0 -1.0 -0.5 -1.0 0.7
Diastolic blood pressure, automated reading 0.3 1.0 1.3 1.0 0.9 0.8 -1.2
Ever depressed for a whole week 3.2 4.0 11.2 1.8 3.4 1.1 0.4
Unable to work because of sickness or disability 0.6 0.8 1.5 1.0 0.6 1.2 -0.5
Commuting to job workplace: Cycle 0.1 0.1 0.5 0.2 0.0 0.2 0.7
Myopia 0.8 1.2 2.3 -1.3 -0.7 -1.5 0.3
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.9 -0.2 -1.0 0.0 -0.3
Cholesterol lowering medication 2.3 3.4 4.1 2.0 1.8 2.0 -1.5
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.3 0.8 1.1 0.5 -0.3
Pain experienced in last month 0.3 0.6 1.6 -0.1 -1.3 0.8 -0.1
Supplements: Calcium 0.7 0.8 1.7 -0.9 -1.3 -0.7 -0.3
Basal cell carcinoma (self-reported) 1.3 1.6 4.2 1.0 0.2 1.0 -2.0
Heart attack/myocardial infarction (self-reported) 2.3 2.9 7.1 1.4 1.0 1.3 -2.7
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.0 -0.9 -1.0 -0.6 0.6
Heart disease (siblings) 0.4 0.5 1.4 0.1 0.5 -0.5 -1.2
Alcohol drinker status: Previous 1.6 1.8 2.6 1.5 1.4 1.6 0.7
Pack years of smoking 0.9 1.4 5.0 0.5 0.3 0.3 -2.2
Impedance of whole body 0.8 4.2 5.9 2.2 1.3 2.4 -2.0
Leg fat mass (left) 0.1 0.4 1.0 0.3 0.7 0.4 1.0
Arm predicted mass (left) 1.4 7.3 11.6 -2.9 -1.0 -3.4 2.9