Hub : Genes

AC087269.1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Coronary 0.203 0.086 3.3e-03 0.019 NA 0.017 NA -0.006 7.3e-02 NA 8.7e-02 NA 5.7e-01
2 GTEx Esophagus Mucosa 0.170 0.055 1.3e-03 0.093 NA 0.042 NA 0.070 8.7e-07 NA 7.8e-04 NA 2.0e-05
3 GTEx Lung 0.203 0.046 4.2e-10 0.189 NA 0.178 NA 0.184 2.1e-14 NA 1.2e-13 NA 4.8e-14
4 GTEx Skin Not Sun Exposed Suprapubic 0.425 0.066 6.7e-11 0.313 NA 0.293 NA 0.308 1.2e-17 NA 1.9e-16 NA 2.2e-17
5 GTEx Skin Sun Exposed Lower leg 0.435 0.051 0.0e+00 0.391 NA 0.398 NA 0.399 2.9e-34 NA 5.3e-35 NA 3.5e-35
6 GTEx Testis 0.200 0.076 6.0e-03 -0.001 NA 0.041 NA 0.021 3.6e-01 NA 6.6e-03 NA 3.9e-02
7 GTEx Thyroid 0.145 0.047 2.0e-04 0.053 NA 0.045 NA 0.070 6.6e-05 NA 2.3e-04 NA 5.1e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.7 1.0 4.7 -2.2 -0.4 -0.6 -0.2 -0.3 -0.4 -1.3
Bipolar Disorder or Schizophrenia 1.5 3.6 9.8 -3.1 -1.6 -1.9 -1.3 -1.3 -1.3 -2.0
Depressed Affect (Nagel 2018) 0.8 1.7 4.6 2.1 1.1 1.4 1.0 1.1 -0.0 1.4
Depression (Nagel 2018) 0.7 1.0 2.4 1.5 0.7 1.0 0.9 0.9 -0.3 1.3
Intelligence (Savage-Jansen 2018) 0.1 0.3 1.2 1.1 0.4 0.5 0.3 0.3 -0.6 -0.2
Neuroticism (Nagel 2018) 1.4 3.2 6.0 2.4 1.8 1.8 1.7 1.7 -0.4 2.2
Schizophrenia (2018) 1.4 2.9 5.1 -2.3 -1.7 -2.0 -1.5 -1.5 -1.3 -1.5
Schizophrenia vs Biploar Disorder 0.2 0.3 0.8 -0.9 -0.4 -0.4 -0.3 -0.2 -0.9 0.2
Worry (Nagel 2018) 1.2 2.5 4.6 2.2 1.6 1.2 1.4 1.4 -0.9 2.0
Alzheimer’s Disease (in mother) 0.7 0.9 1.7 -0.6 -1.0 -0.9 -0.9 -0.9 1.3 -0.7
Alzheimer’s Disease (in father) 0.2 0.2 1.1 1.1 -0.1 -0.3 -0.3 -0.3 0.1 -0.1
Alzheimer’s Disease (including proxy) 0.6 0.9 2.1 0.9 -0.8 -0.7 -1.0 -1.0 1.4 -0.4
Crohns Disease (2017) 0.1 0.2 0.6 -0.7 0.3 -0.1 0.3 0.3 -0.8 0.0
Irritable Bowel Disease (IBD) 0.1 0.1 0.5 0.7 -0.3 -0.2 -0.2 -0.3 0.3 0.0
Ulcerative Colitis (UC) 0.3 0.5 2.5 1.6 -0.4 0.0 -0.2 -0.3 0.8 0.3
Major Depression (MDD) 0.2 0.2 0.4 0.0 -0.5 -0.4 -0.5 -0.5 0.6 -0.3
Reaction Time 0.5 1.0 1.4 1.2 1.0 1.1 1.1 1.1 -0.2 0.9
Verbal and Numeric Reasoning (VNR) 0.4 0.9 4.3 2.1 0.6 0.5 0.6 0.6 -0.6 0.2
Breast Cancer 0.6 1.4 2.6 -1.6 -1.2 -1.3 -1.2 -1.2 -0.0 -1.1
Ovarian Cancer 1.0 1.4 2.4 -1.6 -1.1 -1.3 -1.2 -1.2 0.7 -0.8
Prostate Cancer 1.5 2.1 3.6 -0.9 -1.9 -1.9 -1.8 -1.8 0.4 -0.6
Age at First Birth 0.5 0.7 1.3 0.4 1.0 1.2 0.9 1.0 -0.4 0.4
Bipolar Disorder (2011) 0.8 0.8 2.8 -1.7 -0.8 -0.6 -0.5 -0.5 0.1 -1.1
Body Mass Index (BMI) (2010) 0.8 1.1 5.6 -2.4 -0.7 -0.8 -0.6 -0.6 -0.3 -0.4
Coronary Artery Disease (CAD) 0.8 0.9 2.0 -0.3 -0.7 -0.5 -1.1 -1.3 1.4 -0.9
Crohns Disease (2012) 0.3 0.4 1.6 -1.3 -0.4 -0.6 -0.3 -0.3 0.6 -0.5
Mean Putamen Volume 0.5 0.6 1.1 -0.3 -1.0 -1.0 -0.9 -0.9 0.3 -0.5
Fasting Glucose 0.3 0.4 0.9 0.2 -0.7 -1.0 -0.5 -0.5 0.1 -0.8
HbA1C 4.9 5.4 7.4 -1.1 -2.5 -2.6 -2.7 -2.7 1.4 -2.7
HDL Cholesterol 0.1 0.2 0.6 -0.4 0.3 0.2 0.3 0.3 0.7 0.7
LDL Cholesterol 1.6 2.5 3.6 -0.7 -1.9 -1.6 -1.8 -1.9 1.2 -1.7
Lupus 4.9 7.4 13.5 -3.7 -2.9 -3.1 -2.6 -2.7 0.3 -2.5
Neuroticism (2016) 9.7 14.0 34.8 5.9 3.2 4.0 3.1 3.2 1.3 4.0
Primary Biliary Cirrhosis 0.6 0.9 2.8 -1.3 0.0 -1.0 -0.7 -0.7 -1.7 -0.3
Rheumatoid Arthritis 0.0 0.0 0.1 -0.0 -0.3 -0.3 -0.2 -0.2 0.3 0.0
Schizophrenia (2014) 0.9 2.0 6.6 -2.6 -0.9 -1.3 -0.8 -0.8 -1.6 -1.2
Triglycerides 3.8 6.2 9.9 3.1 2.5 2.7 2.3 2.4 -1.4 2.5
Type 2 Diabetes (T2D) (2012) 2.4 2.7 5.2 -2.3 -1.5 -2.0 -1.6 -1.6 1.0 -1.4
Ulcerative Colitis 0.8 1.2 4.7 1.8 -0.5 0.3 -0.3 -0.3 2.2 0.4
Blood Eosinophil Count 0.0 0.1 0.2 0.4 0.4 0.3 -0.4 -0.3 0.1 -0.1
Blood Platelet Count 0.2 2.3 4.6 1.8 -1.1 -1.2 -1.5 -1.5 2.1 -1.0
Blood Red Count 0.1 0.5 0.9 0.6 0.7 0.2 1.0 1.0 -0.8 0.4
Blood White Count 0.1 0.9 3.5 1.9 -0.6 -0.6 -0.6 -0.5 0.9 -0.7
Heel T-Score 0.5 4.0 5.0 -1.4 -2.0 -2.2 -1.9 -1.9 2.2 -2.2
BMI 0.0 0.0 0.1 0.1 0.1 -0.1 0.3 0.3 0.3 0.0
Height 0.7 14.1 25.5 0.0 4.1 3.5 4.2 4.2 -5.0 3.0
Waist Hip Ratio (WHR) 0.9 4.1 5.7 0.7 -2.2 -2.3 -2.4 -2.4 1.2 -2.3
Systolic Blood Pressure 0.2 0.8 1.7 0.2 -0.7 -1.1 -0.9 -0.9 0.7 -1.3
Smoking Status 0.2 0.6 1.0 -0.7 0.8 0.8 0.8 0.8 -0.4 1.0
Allergy or Eczema 1.4 3.7 4.9 0.9 2.1 2.0 2.2 2.1 -2.2 1.6
Cardiovascular Disease 0.1 0.2 0.5 -0.3 0.4 0.7 0.6 0.6 0.3 0.1
Hypothyroidism (self reported) 1.0 2.3 8.4 2.9 -0.9 -0.7 -1.2 -1.2 1.5 -1.2
Respiratory disease 0.3 0.8 2.2 -1.4 -0.4 -0.5 -0.3 -0.3 1.5 -0.6
Type 2 Diabetes (T2D) (2018) 1.0 1.9 2.7 0.5 1.4 1.5 1.4 1.3 -1.4 1.6
Lung FEV1/FVC ratio 0.4 2.0 2.5 -1.4 1.6 1.2 1.5 1.5 -0.9 1.6
Lung FVC 0.2 1.3 2.8 1.7 1.0 1.0 0.9 0.8 -0.6 1.5
Neuroticism 0.4 1.0 1.5 1.2 0.9 0.9 0.9 0.9 -0.7 1.2
Chronotype (morning person) 0.1 0.1 0.3 -0.3 0.0 -0.5 0.3 0.2 0.5 0.4
Hair Pigment 0.0 1.4 2.2 1.0 0.9 1.2 1.1 1.1 -1.5 1.3
Tanning 0.0 0.2 0.9 -0.9 0.2 0.0 0.1 0.1 0.2 -0.8
Hand grip strength (left) 0.3 0.7 2.0 -1.4 -0.7 -1.1 -0.8 -0.8 -0.4 -0.3
Number of treatments/medications taken 0.3 0.5 2.5 -0.6 0.5 0.2 0.4 0.4 -1.6 0.3
Average weekly spirits intake 0.3 0.4 1.4 -0.4 0.6 0.5 0.6 0.5 1.2 0.5
Sensitivity / hurt feelings 7.7 13.2 21.0 3.1 3.7 4.6 3.9 3.9 -0.3 4.2
Frequency of depressed mood in last 2 weeks 3.2 4.5 8.9 3.0 1.9 2.6 1.8 1.9 0.2 2.3
Hearing difficulty/problems: Yes 3.5 5.3 7.4 0.4 2.7 2.6 2.6 2.6 -1.3 2.7
Relative age of first facial hair 0.1 0.2 0.5 0.7 -0.0 0.1 0.0 0.0 0.4 0.6
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.1 -0.1 1.0 1.0 0.9 0.9 -0.7 0.9
Ever used hormone-replacement therapy (HRT) 8.0 10.2 15.3 0.3 -3.5 -3.9 -3.5 -3.5 2.3 -3.8
Ever had hysterectomy (womb removed) 1.1 1.3 2.1 -1.3 -0.9 -1.4 -1.0 -1.0 -0.5 -1.4
Systolic blood pressure, automated reading 6.1 17.6 26.3 -4.2 -4.2 -5.1 -4.4 -4.4 1.3 -4.7
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.5 -0.4 -0.3 -0.3 -0.2 -0.2 0.7 -0.3
Angina 1.0 1.3 2.7 -0.4 -1.1 -1.1 -1.0 -1.1 1.1 -1.6
Medication for hormone replacement therapy 6.0 6.7 9.6 -0.5 -2.8 -3.0 -2.8 -2.8 2.1 -3.1
Vitamin and mineral supplements 0.8 1.1 1.9 1.4 0.9 1.3 0.9 0.9 -0.4 1.2
Supplements: Zinc 1.7 1.8 5.0 -2.2 -0.9 -1.3 -1.3 -1.2 0.2 -1.4
Medication: Co-codamol 1.4 1.7 3.1 0.0 -1.2 -1.7 -1.8 -1.7 -0.2 -1.1
Medication: Metformin 0.6 0.8 1.8 -1.1 -0.6 -1.0 -0.6 -0.6 -1.3 -0.7
Diabetes (father) 1.9 2.3 5.2 -2.3 -1.3 -1.8 -1.4 -1.4 0.4 -1.4
Diabetes (mother) 1.7 2.1 2.4 -1.4 -1.5 -1.5 -1.4 -1.5 1.4 -1.5
Severe depression (siblings) 0.3 0.4 1.4 -1.2 -0.5 -0.4 -0.1 -0.2 -0.7 -0.5
Pack years adult smoking proportion 0.8 1.3 1.9 -1.4 -0.8 -1.3 -0.8 -0.8 -1.4 -1.1
Impedance of leg (right) 3.5 17.1 35.7 6.0 3.5 5.0 3.6 3.6 0.9 4.5
Leg fat-free mass (left) 1.1 5.7 15.7 -4.0 -1.5 -2.6 -1.6 -1.6 -2.0 -2.4
Trunk fat percentage 1.3 5.0 8.1 -1.6 -2.3 -2.8 -2.3 -2.3 1.0 -2.8
Hand grip strength (right) 0.1 0.2 0.5 -0.7 0.1 -0.3 -0.0 -0.0 -0.6 0.5
Townsend deprivation index at recruitment 0.8 1.2 1.6 0.8 -1.0 -1.2 -1.3 -1.3 0.6 -1.2
Current tobacco smoking 2.3 3.8 10.1 -3.2 -1.6 -2.2 -1.7 -1.7 -0.3 -1.8
Average weekly fortified wine intake 0.2 0.2 0.5 0.7 0.5 0.5 0.4 0.4 -0.1 0.0
Maternal smoking around birth 2.5 3.6 5.2 1.5 2.1 1.9 2.3 2.3 -1.0 2.0
Fed-up feelings 8.2 14.9 22.2 4.7 3.7 4.7 3.7 3.7 -0.2 4.4
Frequency of unenthusiasm / disinterest in last 2 weeks 2.7 3.6 14.2 3.8 1.0 1.5 1.4 1.4 -0.2 1.9
Relative age voice broke 0.6 1.0 2.0 0.6 1.1 1.1 1.0 1.0 -0.2 1.4
Taking other prescription medications 0.1 0.2 0.4 0.2 0.6 0.2 0.5 0.5 -0.5 0.5
Age when periods started (menarche) 2.1 5.0 6.2 2.4 2.2 2.5 2.4 2.4 -0.7 2.4
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.0 -0.7 -0.7 -0.9 -0.8 -0.8 0.1 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 10.3 23.4 42.0 -6.5 -4.7 -5.8 -4.5 -4.5 -0.2 -5.0
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 1.9 -0.7 -1.3 -1.3 -1.4 -1.3 0.9 -0.8
Qualifications: CSEs or equivalent 0.0 0.1 0.1 0.0 -0.2 -0.3 -0.3 -0.2 -0.4 0.1
Serious illness, injury or assault to yourself 2.5 3.0 4.3 0.6 1.8 2.1 2.1 2.1 -1.2 1.7
High blood pressure 3.6 10.1 23.1 -4.8 -2.7 -3.6 -2.7 -2.7 -1.1 -3.5
Hayfever, allergic rhinitis or eczema 1.0 2.2 4.2 0.3 1.5 1.5 1.6 1.6 -2.0 1.2
Multivitamins +/- minerals 0.4 0.5 1.5 -1.1 -0.3 -0.4 -0.2 -0.2 1.2 -0.5
Stomach or abdominal pain in last month 6.2 7.7 11.2 2.2 2.9 2.9 3.1 3.1 -1.3 3.3
Supplements: Glucosamine 0.7 0.9 1.6 0.2 1.3 0.7 1.0 1.0 -1.2 0.9
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.6 -0.2 0.7 0.8 0.6 0.6 -0.4 0.3
Medication: Atenolol 4.1 5.1 7.8 -2.0 -2.4 -2.5 -2.3 -2.3 1.1 -2.8
Medication: Levothyroxine sodium 3.4 5.7 21.5 4.6 1.6 2.5 1.5 1.5 1.5 1.7
Sitting height 0.6 4.2 17.8 -2.3 1.3 0.6 1.4 1.4 -4.2 0.1
Chronic bronchitis/emphysema (father) 2.1 2.4 2.8 1.6 -1.6 -1.2 -1.6 -1.7 1.5 -1.6
High blood pressure (mother) 1.6 2.3 5.7 -0.8 -1.6 -1.5 -1.6 -1.6 -0.0 -2.4
Body mass index (BMI) 4.9 21.0 31.3 -5.6 -4.4 -5.6 -4.5 -4.5 0.4 -5.0
Impedance of leg (left) 4.0 19.3 35.9 6.0 3.8 5.3 4.0 4.0 1.0 4.8
Leg predicted mass (left) 1.0 5.5 15.7 -4.0 -1.4 -2.5 -1.5 -1.5 -2.1 -2.3
Trunk fat mass 1.2 5.2 8.5 -2.3 -2.2 -2.9 -2.2 -2.2 0.2 -2.8
Waist circumference 0.9 3.3 4.8 -2.2 -1.7 -2.2 -1.8 -1.7 0.1 -2.2
Number of incorrect matches in round 0.7 1.1 2.3 0.8 1.0 0.9 1.1 1.1 -1.5 0.9
Past tobacco smoking 1.0 1.8 6.7 2.6 0.9 1.6 0.9 0.9 -0.7 0.8
Alcohol usually taken with meals 0.8 1.4 3.2 -1.8 -1.0 -1.3 -0.9 -0.9 -0.1 -1.4
Nervous feelings 12.6 23.6 32.6 5.7 4.9 5.7 4.8 4.8 -0.2 5.4
Frequency of tenseness / restlessness in last 2 weeks 2.6 4.0 7.4 2.7 1.7 2.4 1.7 1.7 0.7 2.3
Hearing difficulty/problems with background noise 1.2 1.9 2.4 1.3 1.6 1.5 1.5 1.6 -0.4 1.5
Hair/balding pattern: Pattern 2 1.2 1.5 6.5 -2.6 -0.5 -0.8 -0.7 -0.7 1.4 -0.5
Had menopause 4.5 5.7 8.0 -1.3 -2.5 -2.8 -2.6 -2.6 1.6 -2.8
Had other major operations 0.9 1.1 1.8 -1.1 1.1 0.5 1.2 1.2 -1.3 0.6
Forced vital capacity (FVC) 3.7 14.2 18.2 3.4 3.9 4.3 4.0 4.0 -2.3 4.3
Heel bone mineral density (BMD) T-score, automated (right) 9.8 22.5 49.4 -7.0 -4.4 -5.4 -4.3 -4.3 -0.8 -4.7
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.1 0.0 0.9 0.9 1.1 1.1 -0.3 0.8
Qualifications: None of the above 0.2 0.5 0.8 0.1 -0.9 -0.6 -0.7 -0.7 0.9 -0.8
Financial difficulties in last 2 years 0.3 0.4 1.1 0.3 0.4 0.1 0.7 0.7 -0.8 1.0
Mouth/teeth dental problems 1.6 2.5 4.5 1.1 1.7 2.1 1.7 1.7 0.4 1.7
Heart attack 0.3 0.4 1.5 -0.8 -0.4 0.1 -0.3 -0.3 1.2 -0.5
Allergy 0.3 0.7 3.4 1.9 0.1 0.4 -0.0 -0.1 0.9 0.5
Pain all over the body in last month 1.0 1.0 1.6 -0.9 -0.9 -1.1 -1.0 -1.0 -1.3 -1.0
Diabetes (self-reported) 0.2 0.4 0.6 -0.6 -0.6 -0.8 -0.7 -0.7 -0.3 -0.4
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 2.5 1.3 1.2 1.6 1.4 1.4 0.3 0.8
Medication: Ramipril 0.9 1.2 4.3 -2.1 -0.5 -0.9 -0.3 -0.3 -1.5 -0.7
Medication: Simvastatin 0.4 0.6 2.3 -1.5 -0.6 -0.6 -0.8 -0.8 -0.1 -0.4
Fluid intelligence score 0.6 1.2 6.9 2.6 0.5 0.7 0.5 0.5 -0.7 0.2
Illnesses of siblings 0.3 0.4 1.2 1.1 0.2 0.7 0.2 0.2 0.9 0.3
Neuroticism score 19.3 40.2 55.7 7.5 6.3 7.4 6.4 6.4 -1.4 6.9
Weight 1.1 5.5 13.8 -3.7 -1.8 -2.7 -1.8 -1.8 -1.2 -2.5
Impedance of arm (right) 3.9 18.1 42.9 6.6 3.7 5.0 3.9 3.8 0.5 3.9
Arm fat percentage (right) 2.9 11.4 17.2 -3.4 -3.4 -4.1 -3.4 -3.4 0.7 -3.9
Trunk fat-free mass 0.5 2.6 9.9 -3.1 0.0 -0.9 0.0 0.1 -2.8 -0.4
Hip circumference 1.3 5.5 20.5 -4.5 -1.5 -2.2 -1.5 -1.5 -1.0 -2.2
Time employed in main current job 1.5 1.7 6.3 1.4 -1.1 -0.5 -0.9 -0.9 2.5 -0.6
Alcohol intake versus 10 years previously 1.9 2.9 4.5 -0.8 1.8 1.6 1.8 1.8 -1.7 2.1
Father’s age at death 6.4 8.6 16.9 4.1 2.9 3.1 2.9 2.9 -0.8 2.8
Worrier / anxious feelings 17.9 33.7 44.9 6.7 6.0 6.6 5.9 6.0 -0.7 6.4
Frequency of tiredness / lethargy in last 2 weeks 1.2 2.0 10.4 3.2 0.5 1.1 0.6 0.6 0.6 0.9
Falls in the last year 0.6 0.7 2.6 -0.5 0.7 0.5 0.8 0.8 -1.6 0.7
Hair/balding pattern: Pattern 3 0.2 0.3 1.4 1.2 -0.0 0.1 0.0 0.0 -0.9 0.2
Number of live births 0.0 0.1 0.1 0.3 -0.2 -0.2 -0.2 -0.2 -0.0 -0.3
Forced expiratory volume in 1-second (FEV1) 6.0 20.2 27.8 4.1 4.6 5.2 4.7 4.7 -2.0 5.3
Pulse rate 0.2 0.4 0.8 0.7 0.5 0.9 0.8 0.8 -0.1 0.2
Happiness 0.3 0.3 1.5 0.9 0.1 -0.2 0.1 0.1 -1.2 0.2
Noisy workplace 0.2 0.3 0.9 0.5 0.1 0.2 0.1 0.0 1.0 0.8
Qualifications: A levels/AS levels or equivalent 0.6 1.2 3.7 1.9 0.9 1.5 1.0 1.0 0.1 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.6 1.6 0.8 0.8 0.7 0.7 0.9 0.6
Mouth/teeth dental problems: Dentures 7.9 13.4 17.2 -4.0 -3.6 -4.1 -3.7 -3.7 2.0 -3.9
Asthma 0.8 1.5 6.5 -2.6 -0.6 -1.1 -0.6 -0.6 -0.0 -1.4
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.1 2.8 1.1 1.7 1.5 1.6 1.6 -1.0 1.4
Medication: Cholesterol lowering 0.2 0.3 2.2 -1.5 0.1 0.1 0.1 0.1 -0.1 0.2
Depression (self-reported) 0.8 1.0 2.1 1.4 0.7 0.9 0.8 0.8 1.2 0.8
Medication: Lansoprazole 0.1 0.1 0.3 0.1 0.1 -0.2 -0.1 -0.1 -0.5 -0.4
Prospective memory result 0.7 0.9 1.3 -0.5 0.9 0.8 1.1 1.1 -0.9 1.0
Lung cancer (father) 1.2 1.4 1.9 0.5 -1.2 -1.3 -1.3 -1.3 1.4 -1.3
Illnesses of mother 0.4 0.5 1.2 -0.6 0.8 0.3 0.8 0.8 -1.1 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 5.7 18.3 24.4 4.6 4.2 4.8 4.2 4.2 -2.4 4.9
Pulse wave Arterial Stiffness index 2.3 2.7 4.3 -0.9 -1.8 -2.1 -1.9 -1.9 0.2 -1.8
Impedance of arm (left) 3.6 16.6 39.7 6.3 3.6 4.7 3.7 3.7 0.3 3.6
Arm fat mass (right) 3.0 12.4 18.2 -4.2 -3.4 -4.3 -3.4 -3.4 0.1 -4.0
Trunk predicted mass 0.5 2.6 10.1 -3.2 -0.0 -0.9 -0.0 0.0 -2.7 -0.5
Standing height 2.1 21.2 27.7 3.6 4.9 5.3 5.1 5.1 -3.4 4.6
Length of working week for main job 0.3 0.4 1.0 -1.0 -0.6 -0.4 -0.5 -0.5 -0.7 -0.3
Exposure to tobacco smoke at home 0.1 0.1 0.1 -0.2 -0.3 -0.0 -0.3 -0.3 -0.3 -0.3
Breastfed as a baby 1.1 1.4 7.5 2.7 0.6 0.6 0.6 0.6 0.3 0.8
Tense / ‘highly strung’ 5.7 9.4 26.0 5.1 2.4 3.2 2.4 2.4 0.6 3.4
Seen doctor (GP) for nerves, anxiety, tension or depression 3.0 4.6 6.7 1.8 2.4 2.5 2.2 2.2 -0.7 2.6
Hair/balding pattern: Pattern 4 0.0 0.1 0.4 0.7 -0.2 0.4 0.1 0.1 0.2 -0.3
Birth weight of first child 0.2 0.3 1.5 1.2 -0.2 -0.2 -0.3 -0.3 0.7 0.1
Peak expiratory flow (PEF) 9.8 22.6 32.6 3.5 5.1 5.6 5.2 5.2 -1.3 5.7
Pulse wave reflection index 1.9 2.4 3.1 -1.6 -1.6 -1.8 -1.8 -1.7 -0.2 -1.5
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.8 1.3 0.7 1.0 0.6 0.6 0.8 0.4
Loud music exposure frequency 0.4 0.5 1.6 -1.3 -0.3 -0.8 -0.2 -0.2 0.7 -0.6
Qualifications: O levels/GCSEs or equivalent 3.7 5.8 8.9 1.6 2.7 3.0 2.8 2.8 -1.0 2.3
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.7 -0.2 -0.9 -1.3 -1.1 -1.1 -0.6 -0.3
Blood clot in the leg (DVT) 7.5 9.7 12.9 -2.7 -3.3 -3.2 -3.5 -3.5 1.4 -3.6
Medication: Paracetamol 1.8 3.0 4.7 2.2 1.7 2.0 1.4 1.4 -1.0 2.1
Headache pain in last month 4.8 8.3 14.1 3.8 2.7 3.3 2.6 2.6 -0.6 3.4
Medication for cholesterol, blood pressure or diabetes 0.8 1.2 5.4 2.3 0.2 0.4 0.1 0.1 1.6 0.6
Glaucoma (self-reported) 0.8 0.9 1.7 0.3 1.1 0.7 0.9 1.0 -1.3 1.1
Gout (self-reported) 0.2 0.2 1.0 -1.0 -0.5 -0.2 -0.3 -0.3 -0.1 -0.1
Hypothyroidism/myxoedema (self-reported) 5.3 10.3 43.7 6.6 2.1 3.1 1.9 1.9 1.6 2.0
Medication: Amlodipine 0.7 1.0 3.9 -2.0 -0.6 -0.8 -0.6 -0.6 -1.1 -0.5
Medication: Ventolin 100micrograms inhaler 0.7 0.9 6.0 -2.4 0.2 -0.2 0.3 0.3 -0.4 0.1
Birth weight 1.7 3.6 5.0 -1.4 -2.2 -2.2 -2.1 -2.1 1.0 -1.9
Chronic bronchitis/emphysema (mother) 0.5 0.6 2.1 1.4 -0.6 -0.3 -0.5 -0.5 1.0 0.1
High blood pressure (siblings) 0.1 0.2 0.5 -0.7 -0.3 -0.6 -0.4 -0.4 -0.4 -0.1
Forced vital capacity (FVC), Best measure 3.0 10.9 14.3 3.8 3.2 3.5 3.2 3.2 -2.5 3.7
Body fat percentage 2.0 7.8 11.5 -2.5 -2.9 -3.4 -2.9 -2.9 1.1 -3.3
Leg fat percentage (right) 3.2 11.4 17.6 -3.0 -3.5 -4.2 -3.6 -3.6 1.2 -3.6
Arm fat-free mass (right) 0.8 4.2 16.6 -4.1 -1.0 -2.0 -1.0 -1.0 -1.9 -1.5
Exposure to tobacco smoke outside home 0.3 0.4 0.8 0.2 0.7 0.9 0.7 0.7 -0.2 0.7
Comparative body size at age 10 9.1 25.2 31.4 -5.2 -5.2 -5.6 -5.5 -5.5 1.4 -5.3
Number of full brothers 0.3 0.4 0.8 0.7 -0.5 -0.9 -0.5 -0.6 -0.9 -0.2
Worry too long after embarrassment 10.1 16.9 22.6 4.7 3.9 4.8 4.3 4.3 -0.5 4.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 1.0 1.6 1.3 1.0 0.7 0.9 0.9 -1.1 0.9
Wheeze or whistling in the chest in last year 1.2 2.1 3.4 -1.9 -1.2 -1.7 -1.1 -1.1 -1.1 -1.7
Number of children fathered 0.9 1.1 3.1 -1.8 0.7 0.2 1.0 1.0 -1.3 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.7 2.9 -1.7 1.2 1.4 1.6 1.6 -0.0 0.7
Age at first live birth 1.7 3.0 5.4 1.4 1.8 2.3 1.9 1.9 -0.1 1.9
Pulse wave peak to peak time 2.9 3.4 5.5 1.2 2.0 2.3 2.1 2.1 -0.3 1.9
Health satisfaction 1.2 1.5 2.9 -1.5 -1.1 -1.4 -1.1 -1.1 0.1 -1.7
Shortness of breath walking on level ground 2.3 2.7 3.9 -1.7 -1.8 -1.8 -1.5 -1.5 1.2 -2.0
Qualifications: College or University degree 0.1 0.2 1.3 1.1 0.1 0.3 0.0 0.0 -0.5 -0.3
Eye problems/disorders: None of the above 2.2 2.5 3.8 -0.4 1.9 1.7 2.0 1.9 0.1 1.9
Mouth/teeth dental problems: Loose teeth 1.1 1.3 2.2 -0.1 -1.4 -1.5 -1.2 -1.2 -1.2 -0.8
Emphysema/chronic bronchitis 5.4 6.1 9.9 -3.1 -2.5 -3.0 -2.5 -2.5 -0.3 -2.4
Medication for pain relief, constipation, heartburn 0.9 1.5 2.0 -1.2 -1.2 -1.4 -1.0 -1.1 1.3 -1.3
Neck or shoulder pain in last month 0.5 0.7 2.5 1.6 0.7 0.9 0.4 0.5 0.2 0.6
Medication: Blood pressure 1.3 2.3 6.6 -2.6 -0.8 -1.3 -0.9 -0.8 -2.0 -1.5
Angina (self-reported) 1.0 1.4 2.7 -0.6 -1.2 -1.2 -1.1 -1.1 1.1 -1.6
Migraine (self-reported) 0.5 0.6 1.1 1.0 0.7 0.9 0.5 0.5 -0.3 1.1
Medication: Ibuprofen 0.8 1.0 1.4 0.9 1.1 1.0 1.2 1.2 -0.3 0.9
Medication: Allopurinol 0.6 0.8 1.8 -1.3 -1.0 -0.7 -0.8 -0.8 0.3 -0.8
Medication: Omeprazole 0.6 0.7 2.0 -0.1 0.9 0.6 0.9 0.9 -1.4 0.7
Medication: Seretide 50 evohaler 0.2 0.3 1.7 0.0 0.3 -0.1 0.1 0.1 -1.3 -0.2
Mean time to correctly identify matches 0.3 0.5 0.7 0.5 0.8 0.7 0.8 0.8 -0.6 0.7
Heart disease (mother) 0.1 0.1 0.4 0.7 0.3 0.4 0.1 0.1 0.4 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 3.5 1.9 0.5 1.0 0.7 0.7 1.7 0.6
Whole body fat mass 2.1 8.6 12.8 -3.2 -2.9 -3.6 -2.9 -2.9 0.4 -3.4
Leg fat mass (right) 3.5 13.5 19.9 -4.1 -3.7 -4.5 -3.7 -3.7 0.6 -4.0
Arm predicted mass (right) 0.8 4.1 15.4 -3.9 -1.0 -2.0 -1.0 -1.0 -1.9 -1.5
Pulse rate, automated reading 0.1 0.2 1.6 -1.3 0.1 -0.0 0.1 0.1 0.2 0.0
Alcohol intake frequency. 0.6 1.5 2.4 -0.9 1.6 1.5 1.3 1.4 -0.6 1.1
Comparative height size at age 10 0.3 1.8 6.2 -0.8 1.1 0.8 1.2 1.2 -2.5 1.0
Number of full sisters 3.1 3.8 4.7 -2.0 -1.9 -2.1 -2.0 -2.0 1.3 -2.2
Suffer from ‘nerves’ 10.8 16.9 31.3 5.6 3.9 4.5 3.9 3.9 -0.7 4.5
Overall health rating 2.9 6.2 10.8 -1.5 -2.7 -3.3 -2.6 -2.6 0.5 -3.0
Chest pain or discomfort 0.2 0.2 1.2 1.1 -0.0 -0.3 -0.0 0.0 -0.6 -0.1
Had major operations 0.6 0.7 1.0 -0.5 0.9 1.0 1.0 1.0 0.1 0.7
Age at last live birth 4.9 7.1 10.7 1.4 2.9 3.3 3.1 3.1 -0.8 3.0
Family relationship satisfaction 0.7 0.9 2.2 1.5 -0.8 -0.9 -0.8 -0.8 0.7 -0.8
Leg pain on walking 0.3 0.4 1.9 -1.4 0.1 0.0 0.5 0.5 -0.5 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 1.3 0.1 1.1 1.0 1.2 1.1 -0.8 1.1
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.5 0.5 -0.5 -0.5 -0.7 -0.7 0.3 -0.3
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.9 -1.0 0.1 -0.2 -0.2 -0.2 -1.4 -0.0
Medication: Aspirin 3.6 4.7 6.1 -2.1 -2.4 -2.2 -2.4 -2.4 0.1 -2.5
Supplements: Vitamin C 1.3 1.6 2.7 -1.6 -0.9 -1.6 -1.1 -1.1 -1.2 -1.0
Knee pain experienced in last month 0.1 0.2 0.8 -0.5 -0.2 -0.3 -0.1 -0.1 -0.9 -0.2
Hypertension (Self-reported) 3.8 10.6 23.2 -4.8 -2.8 -3.8 -2.8 -2.8 -0.9 -3.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 2.3 -0.4 1.1 0.8 1.5 1.5 -1.5 1.3
Illnesses of father: Heart disease 0.2 0.2 1.2 -0.2 0.1 0.3 0.4 0.4 1.1 -0.1
Illnesses of siblings: Diabetes 2.3 2.8 4.6 -0.8 -1.9 -2.1 -1.9 -1.9 0.6 -1.9
Smoking status: Previous 0.7 1.0 1.8 -1.0 -0.9 -1.4 -0.9 -0.9 0.9 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 3.8 8.0 10.5 1.9 3.1 3.2 3.1 3.1 -1.9 3.0
Whole body fat-free mass 0.6 3.6 14.2 -3.8 -0.6 -1.6 -0.6 -0.6 -2.5 -1.2
Leg fat-free mass (right) 0.9 4.8 15.4 -3.9 -1.2 -2.3 -1.2 -1.2 -2.1 -2.1
Arm fat percentage (left) 3.0 12.1 18.7 -3.3 -3.5 -4.3 -3.6 -3.5 0.8 -4.1
Average weekly red wine intake 2.1 3.1 6.2 -1.8 -1.6 -2.1 -1.5 -1.6 0.6 -2.5
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.1 -0.2 -0.0 0.0 0.0 0.0 -0.2 -0.0
Mood swings 7.3 13.3 23.0 4.8 3.5 4.2 3.5 3.5 -0.8 3.7
Loneliness, isolation 0.3 0.4 2.3 1.5 0.1 0.6 0.1 0.1 0.3 0.5
Long-standing illness, disability or infirmity 0.6 0.9 1.1 -1.0 1.0 0.8 1.0 1.1 -0.8 0.5
Ever had bowel cancer screening 3.8 4.5 6.4 1.3 2.4 2.2 2.5 2.5 -1.2 2.2
Diabetes diagnosed by doctor 0.6 0.9 2.5 -1.6 -0.8 -1.0 -0.9 -0.9 -0.3 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 2.4 -1.6 -0.7 -1.1 -0.6 -0.6 -1.1 -0.7
Friendships satisfaction 0.7 0.9 1.3 -0.8 -1.1 -0.9 -1.0 -1.0 1.1 -0.4
Qualifications: nursing, teaching 0.5 0.9 1.5 -0.1 1.2 1.0 1.2 1.2 -0.3 0.8
Commuting to job workplace: Walk 0.4 0.4 1.2 -1.1 0.3 0.5 0.1 0.1 1.1 -0.1
Eye problems/disorders: Cataract 1.3 1.5 3.1 -0.5 -1.4 -1.0 -1.4 -1.4 0.7 -1.8
Mouth/teeth dental problems: Mouth ulcers 3.7 5.9 9.8 3.1 2.5 2.6 2.4 2.4 -1.5 2.3
Medication for cholesterol 3.0 4.5 7.3 2.0 2.2 2.7 2.2 2.2 -0.2 2.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.0 2.3 3.5 0.7 1.6 1.6 1.7 1.8 -1.1 1.9
Back pain experienced in last month 5.1 7.4 9.6 -0.0 3.1 2.6 3.0 3.0 -2.8 3.1
Mineral and other dietary supplements 2.1 2.8 5.6 2.4 1.4 2.1 1.5 1.5 -0.4 1.8
Breast cancer (self-reported) 0.5 0.6 0.9 -0.1 -0.8 -1.0 -0.9 -0.9 0.4 -0.9
Asthma (self-reported) 1.0 2.0 7.7 -2.8 -0.9 -1.4 -0.9 -0.8 0.0 -1.5
Osteoporosis (self-reported) 1.1 1.3 2.3 1.5 0.9 1.2 1.0 1.0 1.4 0.9
Osteoarthritis (self-reported) 0.5 0.6 3.5 -1.9 -0.3 -0.6 -0.2 -0.3 0.5 -0.2
Medication: Aspirin 3.3 4.4 5.9 -1.8 -2.4 -2.1 -2.4 -2.4 0.4 -2.3
Medication: Gliclazide 0.2 0.2 1.1 -1.1 -0.0 -0.2 -0.1 -0.1 -0.6 -0.3
Illnesses of father: None of the above (group 1) 0.9 1.1 1.5 1.2 0.9 1.0 1.0 0.9 -1.2 1.2
Smoking status: Current 2.0 3.2 12.0 -3.5 -1.2 -1.8 -1.3 -1.3 -0.5 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.5 3.2 12.2 3.5 1.2 1.6 1.2 1.2 0.6 1.6
Whole body water mass 0.7 3.7 14.6 -3.8 -0.6 -1.6 -0.6 -0.6 -2.5 -1.3
Leg predicted mass (right) 0.9 4.9 15.1 -3.9 -1.2 -2.3 -1.2 -1.2 -2.1 -2.1
Arm fat mass (left) 2.7 11.3 16.9 -4.0 -3.2 -4.1 -3.3 -3.3 -0.0 -3.9
Number of self-reported non-cancer illnesses 0.7 1.2 1.7 -0.8 1.3 0.9 1.3 1.3 -0.9 0.9
Average weekly champagne plus white wine intake 0.5 0.7 1.1 -1.1 -0.8 -1.0 -0.9 -0.9 -0.2 -0.8
Miserableness 12.1 21.0 28.2 5.3 4.5 5.3 4.7 4.7 -1.0 5.0
Guilty feelings 9.0 13.6 21.7 4.7 3.6 4.1 3.6 3.6 -1.4 3.9
Wears glasses or contact lenses 0.2 0.2 0.4 -0.5 0.5 0.5 0.5 0.6 0.4 -0.2
Ever taken oral contraceptive pill 1.7 1.9 3.2 1.2 1.1 1.4 1.3 1.3 -1.8 1.5
Hearing aid user 1.1 1.2 2.6 -0.3 1.1 1.0 1.1 1.1 -1.6 0.9
Mother’s age at death 2.3 2.8 3.9 2.0 1.6 1.8 1.8 1.8 -0.6 1.8
Financial situation satisfaction 0.1 0.2 0.5 -0.7 0.3 -0.1 0.4 0.4 -0.4 0.3
Tinnitus: Yes, now most or all of the time 2.0 2.4 3.5 0.4 1.7 1.8 1.7 1.7 -1.2 1.9
Commuting to job workplace: Public transport 0.6 0.7 1.3 0.2 0.9 1.1 0.9 0.9 0.9 0.8
Eye problems/disorders: Glaucoma 0.1 0.1 0.9 -0.2 0.0 -0.3 -0.2 -0.1 -0.9 0.0
Medication: Blood pressure 3.5 6.6 17.1 -4.1 -2.1 -3.0 -1.9 -1.9 -1.5 -2.5
Pain type(s) experienced in last month: Hip pain 0.2 0.2 1.3 -1.2 -0.2 -0.3 0.0 -0.0 -0.3 -0.2
Supplements: Fish oil (including cod liver oil) 3.5 4.6 7.6 -2.8 -2.1 -2.7 -2.0 -2.0 1.2 -1.9
High cholesterol (Self-reported) 0.7 1.2 5.2 -2.3 -0.8 -0.7 -0.9 -0.9 0.6 -0.4
Medication: Bendroflumethiazide 2.7 4.1 15.0 -3.9 -1.4 -1.8 -1.5 -1.4 -1.3 -1.7
Medication: Paracetamol 0.8 1.2 4.0 2.0 0.9 1.1 0.5 0.5 -0.3 1.4
Medication: Lisinopril 0.5 0.6 1.4 -0.3 -0.9 -1.2 -0.8 -0.8 -0.7 -0.7
Medication: Atorvastatin 1.2 1.5 2.2 -1.5 -1.3 -0.8 -1.1 -1.2 1.2 -1.2
Illnesses of father: High blood pressure 0.2 0.2 0.4 -0.7 -0.3 -0.4 -0.5 -0.5 0.1 -0.2
Alcohol drinker status: Never 0.8 1.0 1.7 0.7 1.2 1.3 1.1 1.2 0.3 0.8
Ever smoked 0.3 0.5 2.9 -1.7 0.3 -0.3 0.2 0.2 0.5 0.6
Basal metabolic rate 0.8 4.2 15.1 -3.9 -1.0 -2.0 -1.0 -1.0 -2.2 -1.6
Leg fat percentage (left) 2.9 10.6 16.9 -3.1 -3.4 -4.1 -3.4 -3.4 1.1 -3.4
Arm fat-free mass (left) 0.8 4.0 17.7 -4.2 -0.7 -1.6 -0.7 -0.7 -2.2 -1.2
Number of operations (self-reported) 1.0 1.5 6.9 -2.6 0.7 -0.1 0.6 0.6 -1.4 -0.0
Average weekly beer plus cider intake 4.9 7.1 12.0 3.1 2.4 3.3 2.4 2.4 -0.3 3.5
Irritability 19.4 32.9 46.5 6.4 5.7 6.8 5.7 5.8 -1.2 6.5
Risk taking 2.5 3.7 9.3 -3.1 -1.9 -2.0 -1.8 -1.8 -0.3 -1.6
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.6 0.1 0.5 0.5 0.8 0.8 -0.3 0.8
Fractured/broken bones in last 5 years 0.3 0.4 1.0 1.0 0.2 0.6 0.4 0.4 0.9 0.6
Age started oral contraceptive pill 0.6 0.8 2.2 1.5 0.8 0.9 0.8 0.9 -0.4 0.4
Diastolic blood pressure, automated reading 6.5 20.1 28.8 -5.2 -4.4 -5.4 -4.5 -4.5 1.3 -4.8
Ever depressed for a whole week 2.1 2.5 3.7 0.9 1.9 1.8 1.9 1.9 -0.2 1.6
Unable to work because of sickness or disability 0.3 0.4 0.7 0.0 -0.7 -0.8 -0.6 -0.6 -0.6 -0.8
Commuting to job workplace: Cycle 0.0 0.1 0.2 -0.5 0.1 0.2 0.0 0.0 0.4 -0.0
Myopia 3.1 4.5 5.9 2.3 2.1 2.2 2.3 2.3 -0.4 2.4
Vascular/heart problems diagnosed by doctor 3.2 8.8 18.6 4.3 2.6 3.3 2.6 2.6 0.5 3.4
Cholesterol lowering medication 0.8 1.2 1.7 -0.8 -1.2 -1.1 -1.3 -1.3 1.1 -0.8
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.3 0.4 0.5 0.4 0.5 0.5 -0.6 0.4
Pain experienced in last month 1.3 2.1 3.5 -0.7 -1.5 -1.4 -1.5 -1.4 1.9 -1.6
Supplements: Calcium 0.2 0.2 0.8 0.5 -0.3 -0.4 -0.3 -0.4 0.9 -0.4
Basal cell carcinoma (self-reported) 0.7 0.8 1.5 -0.5 1.0 0.7 1.2 1.2 -0.9 0.7
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.5 -0.9 -0.3 0.2 -0.2 -0.2 1.2 -0.3
Deep venous thrombosis (DVT) (self-reported) 8.1 10.4 13.6 -3.0 -3.3 -3.4 -3.6 -3.6 1.3 -3.7
Heart disease (siblings) 0.2 0.2 0.4 0.4 -0.6 -0.6 -0.4 -0.4 -0.1 -0.5
Alcohol drinker status: Previous 1.9 2.1 4.1 -0.1 1.5 1.3 1.5 1.5 -2.0 1.6
Pack years of smoking 0.7 1.1 1.6 -1.1 -0.8 -1.2 -0.8 -0.8 -1.3 -1.1
Impedance of whole body 4.1 20.7 44.0 6.6 4.0 5.5 4.2 4.1 0.7 4.5
Leg fat mass (left) 3.2 12.5 18.8 -4.0 -3.5 -4.3 -3.5 -3.5 0.5 -3.9
Arm predicted mass (left) 0.8 4.1 18.2 -4.3 -0.8 -1.7 -0.8 -0.8 -2.0 -1.2