[Hub]/) : Traits : Forced vital capacity (FVC), Best measure : ← →

chr11:64,663,227-69,476,279

Best TWAS P=6.22e-37 · Best GWAS P=4.38e-34 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	GTEx	Esophagus Muscularis	RAD9A	0.25	0.26	lasso	2	0.26	6.2e-16	-12.17	-12.7	6.2e-37	0.99	0.00	1.00	TRUE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC87	0.03	0.02	blup	34	0.02	2.0e-03	5.42	6.6	4.6e-11	-0.13	0.03	0.40	TRUE
3	GTEx	Adrenal Gland	RAD9A	0.46	0.08	lasso	3	0.22	2.9e-08	0.25	-6.0	2.5e-09	0.53	0.11	0.87	TRUE
16	GTEx	Esophagus Muscularis	MRGPRF	0.09	0.01	lasso	3	0.01	1.3e-01	-5.15	5.8	7.0e-09	0.02	0.03	0.77	TRUE
28	METSIM	Adipose	CTD-3074O7.12	0.12	0.12	bslmm	265	0.12	4.2e-18	5.05	-5.5	4.9e-08	0.24	0.73	0.27	TRUE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	CTSF	0.05	0.04	blup	35	0.04	1.2e-05	5.12	5.5	5.1e-08	-0.16	0.02	0.98	TRUE
44	The Cancer Genome Atlas	Thyroid Carcinoma	PELI3	0.04	0.04	enet	4	0.03	9.0e-04	5.15	-5.4	6.5e-08	0.12	0.02	0.87	TRUE
12	GTEx	Esophagus Gastroesophageal Junction	KCNK7	0.28	0.01	enet	42	0.15	5.9e-06	0.21	-5.3	1.1e-07	0.05	0.03	0.40	TRUE
7	GTEx	Artery Tibial	CTD-3074O7.12	0.08	0.01	enet	15	0.03	2.6e-03	-3.19	-5.3	1.4e-07	0.23	0.40	0.43	TRUE
1	CommonMind	Brain Pre-frontal Cortex	SF3B2	0.03	0.03	lasso	2	0.03	1.5e-04	-4.98	5.2	2.0e-07	-0.14	0.11	0.88	TRUE
8	GTEx	Brain Cerebellar Hemisphere	ZDHHC24	0.22	0.11	enet	15	0.16	8.2e-05	5.13	-5.2	2.0e-07	0.08	0.18	0.17	TRUE
23	GTEx	Skin Sun Exposed Lower leg	RAD9A	0.33	0.02	enet	48	0.12	4.4e-10	-12.17	-5.2	2.6e-07	0.43	0.00	1.00	TRUE
32	ROSMAP	Brain Pre-frontal Cortex	CTSF	0.07	0.08	blup	244	0.07	1.6e-09	5.16	5.1	2.9e-07	-0.15	0.66	0.34	TRUE
5	GTEx	Artery Tibial	RAD9A	0.39	0.26	lasso	2	0.24	3.5e-19	-12.17	-12.2	5.4e-34	1.00	0.00	1.00	FALSE
24	GTEx	Testis	RAD9A	0.72	0.50	lasso	4	0.49	1.1e-24	-12.17	-12.1	7.7e-34	1.00	0.00	1.00	FALSE
20	GTEx	Nerve Tibial	RAD9A	0.53	0.24	lasso	10	0.23	5.6e-16	-12.17	-11.9	9.5e-33	0.99	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	RAD9A	0.43	0.22	lasso	6	0.23	7.1e-19	-12.17	-11.5	9.3e-31	0.97	0.00	1.00	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	RAD9A	0.34	0.17	enet	21	0.20	1.1e-25	-12.17	-11.3	1.0e-29	0.89	0.00	1.00	FALSE
10	GTEx	Cells Transformed fibroblasts	RAD9A	0.24	0.16	lasso	3	0.16	3.6e-12	-12.17	-11.3	1.1e-29	0.92	0.00	1.00	FALSE
11	GTEx	Colon Transverse	RAD9A	0.40	0.16	lasso	8	0.16	7.2e-08	-12.17	-10.7	1.4e-26	0.88	0.00	1.00	FALSE
18	GTEx	Muscle Skeletal	RAD9A	0.12	0.02	lasso	4	0.03	4.2e-04	-12.17	-9.4	4.2e-21	0.83	0.00	0.99	FALSE
26	GTEx	Thyroid	RAD9A	0.27	0.07	lasso	6	0.20	1.8e-15	-12.17	-9.3	1.3e-20	0.70	0.00	1.00	FALSE
34	YFS	Blood	RAD9A	0.08	0.02	lasso	7	0.04	5.4e-12	-12.17	-9.2	3.9e-20	0.78	0.00	1.00	FALSE
13	GTEx	Esophagus Muscularis	TCIRG1	0.10	0.09	lasso	2	0.06	8.7e-05	-5.20	6.3	2.9e-10	-0.43	0.13	0.41	FALSE
33	YFS	Blood	CATSPER1	0.02	0.01	blup	352	0.01	5.5e-04	-4.78	5.8	8.4e-09	-0.21	0.03	0.95	FALSE
21	GTEx	Pancreas	DPP3	0.19	0.13	lasso	8	0.14	1.4e-06	4.74	-5.7	1.5e-08	0.15	0.66	0.31	FALSE
27	GTEx	Whole Blood	SF3B2	0.09	0.07	lasso	11	0.05	1.7e-05	-4.89	5.6	2.3e-08	-0.14	0.10	0.89	FALSE
9	GTEx	Breast Mammary Tissue	DPP3	0.14	0.07	lasso	2	0.05	1.5e-03	4.74	-5.4	5.9e-08	0.11	0.39	0.38	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	CCS	0.08	0.04	lasso	9	0.06	8.9e-08	5.02	-5.4	8.3e-08	0.20	0.34	0.66	FALSE
14	GTEx	Esophagus Muscularis	IGHMBP2	0.12	0.06	enet	17	0.06	9.4e-05	3.59	5.3	9.1e-08	0.05	0.62	0.28	FALSE
29	NTR	Blood	CCS	0.03	0.04	lasso	2	0.04	1.2e-11	4.96	-5.3	1.1e-07	0.23	0.08	0.92	FALSE
35	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	DPP3	0.05	0.02	blup	41	0.02	2.8e-02	4.70	-5.3	1.3e-07	0.15	0.02	0.67	FALSE
6	GTEx	Artery Tibial	DPP3	0.07	0.04	lasso	3	0.03	3.2e-03	5.17	-5.3	1.4e-07	0.13	0.41	0.50	FALSE
25	GTEx	Testis	CTD-3074O7.5	0.22	0.16	enet	16	0.19	8.0e-09	5.18	5.2	1.6e-07	-0.18	0.69	0.31	FALSE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZDHHC24	0.03	0.03	blup	47	0.03	1.5e-04	5.16	5.2	1.6e-07	-0.20	0.03	0.95	FALSE
43	The Cancer Genome Atlas	Rectum Adenocarcinoma	RPS6KB2	0.17	0.13	lasso	2	0.12	1.2e-03	5.46	-5.2	1.6e-07	0.14	0.00	0.90	FALSE
19	GTEx	Nerve Tibial	SF3B2	0.13	0.12	lasso	3	0.10	2.3e-07	-4.89	5.2	1.7e-07	-0.15	0.05	0.94	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SAPS3	0.04	0.02	blup	84	0.04	2.5e-05	-3.40	5.2	1.7e-07	0.00	0.22	0.77	FALSE
4	GTEx	Artery Aorta	ZDHHC24	0.09	0.09	lasso	2	0.06	2.0e-04	5.16	5.2	2.3e-07	-0.14	0.52	0.25	FALSE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	BANF1	0.03	0.00	blup	44	0.02	3.9e-03	-2.76	5.2	2.3e-07	-0.13	0.02	0.40	FALSE
39	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DPP3	0.05	0.07	lasso	5	0.06	1.4e-04	5.16	-5.2	2.4e-07	0.13	0.02	0.90	FALSE
22	GTEx	Skin Not Sun Exposed Suprapubic	DPP3	0.08	0.09	lasso	1	0.08	2.3e-05	5.13	-5.1	2.9e-07	0.13	0.54	0.28	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	ZDHHC24	0.03	0.04	lasso	1	0.04	6.4e-06	5.12	5.1	3.0e-07	-0.13	0.03	0.96	FALSE
17	GTEx	Muscle Skeletal	SF3B2	0.14	0.09	lasso	6	0.09	9.5e-09	-4.95	5.1	3.1e-07	-0.15	0.07	0.93	FALSE