[Hub]/) : Traits : Whole body fat-free mass : ← →

chr1:154,238,383-155,910,830

Best TWAS P=2.99e-41 · Best GWAS P=4.44e-38 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	GTEx	Skin Sun Exposed Lower leg	ADAM15	0.14	0.09	lasso	4	0.08	6.1e-07	12.901	-13.5	3.0e-41	-0.96	0.00	1.00	TRUE
1	GTEx	Brain Cerebellar Hemisphere	DCST2	0.45	0.10	lasso	6	0.16	6.6e-05	-4.162	9.7	2.0e-22	0.75	0.01	0.96	TRUE
2	GTEx	Brain Nucleus accumbens basal ganglia	DCST2	0.28	0.04	lasso	5	0.13	2.0e-04	12.901	8.2	3.3e-16	0.69	0.02	0.90	TRUE
7	GTEx	Esophagus Mucosa	MUC1	0.17	0.20	lasso	4	0.18	5.6e-12	-7.492	-7.1	9.9e-13	-0.12	1.00	0.00	TRUE
13	GTEx	Testis	MUC1	0.20	0.02	lasso	7	0.07	7.5e-04	-7.566	-6.5	1.1e-10	-0.11	0.27	0.05	TRUE
8	GTEx	Pancreas	THBS3	0.36	0.14	lasso	6	0.12	1.0e-05	2.897	-6.1	1.1e-09	-0.34	0.18	0.54	TRUE
22	The Cancer Genome Atlas	Colon Adenocarcinoma	ADAM15	0.15	0.02	blup	49	0.08	1.4e-05	6.463	-6.1	1.3e-09	-0.34	0.03	0.04	TRUE
16	METSIM	Adipose	DCST2	0.04	0.04	enet	12	0.04	4.3e-07	-3.990	5.6	2.0e-08	0.47	0.86	0.11	TRUE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIM46	0.03	0.01	blup	32	0.01	4.9e-03	-7.441	-5.4	7.8e-08	-0.11	0.00	0.63	TRUE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZBTB7B	0.05	0.06	lasso	2	0.05	1.8e-06	12.901	-12.9	4.7e-38	-1.00	0.00	1.00	FALSE
9	GTEx	Pancreas	RP11-263K19.4	0.22	0.06	enet	23	0.05	3.1e-03	2.897	-8.5	2.3e-17	-0.43	0.06	0.49	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	SLC50A1	0.06	0.02	bslmm	331	0.03	4.3e-05	-7.492	-7.4	1.8e-13	-0.27	0.65	0.04	FALSE
17	NTR	Blood	ZBTB7B	0.02	0.02	lasso	1	0.01	5.4e-05	7.171	7.2	7.4e-13	0.67	0.87	0.03	FALSE
4	GTEx	Breast Mammary Tissue (Female)	FAM189B	0.05	-0.01	lasso	2	0.00	4.8e-01	-6.674	6.7	2.8e-11	0.09	0.04	0.07	FALSE
19	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM46	0.03	0.00	blup	33	0.02	3.6e-03	-7.492	-6.5	7.2e-11	-0.11	0.01	0.68	FALSE
23	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MUC1	0.04	0.01	enet	4	0.02	1.3e-03	-7.492	-6.4	1.9e-10	-0.15	0.00	0.89	FALSE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RAG1AP1	0.07	0.00	blup	76	0.00	2.9e-01	-3.101	-6.2	4.1e-10	-0.17	0.02	0.25	FALSE
14	GTEx	Thyroid	DCST2	0.16	0.12	lasso	2	0.11	6.4e-09	-4.162	6.2	4.7e-10	0.53	0.38	0.62	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	GBAP1	0.15	0.06	lasso	4	0.06	3.6e-04	-7.566	6.2	5.2e-10	0.11	0.54	0.04	FALSE
6	GTEx	Esophagus Mucosa	ADAM15	0.11	0.02	enet	16	0.04	1.5e-03	-5.708	-6.1	1.1e-09	-0.43	0.13	0.78	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	LENEP	0.01	0.00	blup	37	0.01	1.6e-03	-3.880	5.9	4.1e-09	0.48	0.02	0.30	FALSE
25	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ADAM15	0.09	0.00	blup	49	0.02	3.6e-02	0.036	-5.6	2.0e-08	-0.43	0.01	0.09	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	GBA	0.05	0.01	lasso	2	0.01	2.3e-02	6.707	-5.5	3.1e-08	-0.07	0.02	0.04	FALSE
15	GTEx	Vagina	GBAP1	0.27	0.08	lasso	7	0.17	1.3e-04	-5.716	5.5	3.3e-08	0.09	0.25	0.05	FALSE
12	GTEx	Spleen	SHC1	0.22	0.14	lasso	2	0.08	4.0e-03	-5.716	-5.5	4.5e-08	-0.15	0.14	0.05	FALSE
3	GTEx	Brain Putamen basal ganglia	DCST2	0.56	0.05	enet	11	0.10	2.8e-03	-4.162	5.2	1.6e-07	0.47	0.18	0.58	FALSE
5	GTEx	Colon Sigmoid	GBAP1	0.16	0.13	enet	8	0.14	8.4e-06	3.286	5.1	2.8e-07	0.09	0.65	0.04	FALSE