[Hub]/) : Traits : Impedance of whole body :

chr2:217,908,472-221,058,583

Best TWAS P=9.3e-13 · Best GWAS P=3.12e-15 conditioned to 0.0192

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PLCD4 0.06 0.09 blup 382 0.09 1.3e-10 -6.19 5.7 1.0e-08 -0.01 0.08 0.92 FALSE
2 GTEx Adipose Subcutaneous USP37 0.05 0.03 lasso 6 0.03 2.0e-03 -3.90 -5.3 1.0e-07 0.03 0.09 0.91 FALSE
3 GTEx Artery Aorta PLCD4 0.14 0.18 lasso 4 0.18 2.1e-10 -6.16 6.2 6.7e-10 -0.02 0.06 0.94 FALSE
4 GTEx Artery Aorta USP37 0.08 0.05 lasso 4 0.04 1.7e-03 -5.67 -5.7 1.6e-08 -0.01 0.07 0.61 FALSE
5 GTEx Artery Tibial PLCD4 0.07 0.02 lasso 2 0.03 9.9e-04 -6.01 5.6 1.7e-08 0.00 0.07 0.91 FALSE
6 GTEx Brain Cerebellar Hemisphere PLCD4 0.12 0.15 lasso 2 0.07 8.9e-03 -6.13 6.1 9.0e-10 -0.02 0.07 0.68 FALSE
7 GTEx Brain Cerebellar Hemisphere RQCD1 0.13 0.04 lasso 11 0.01 2.1e-01 -6.05 -7.0 2.3e-12 0.01 0.05 0.64 TRUE
8 GTEx Brain Cerebellar Hemisphere RP11-316O14.1 0.52 0.34 lasso 4 0.35 6.1e-10 7.32 7.1 9.3e-13 0.04 0.00 1.00 TRUE
9 GTEx Brain Cerebellum USP37 0.13 0.16 lasso 1 0.15 4.2e-05 -6.19 6.2 5.9e-10 -0.02 0.07 0.86 FALSE
10 GTEx Brain Cerebellum RP11-316O14.1 0.39 0.29 enet 10 0.30 1.7e-09 7.10 6.4 1.3e-10 0.04 0.01 0.99 FALSE
11 GTEx Brain Hypothalamus RP11-316O14.1 0.28 0.26 lasso 4 0.17 8.1e-05 6.99 7.0 3.6e-12 0.04 0.01 0.98 FALSE
12 GTEx Breast Mammary Tissue BCS1L 0.05 0.03 enet 7 0.03 6.8e-03 5.37 5.5 4.4e-08 -0.05 0.19 0.47 FALSE
13 GTEx Breast Mammary Tissue USP37 0.20 0.02 lasso 5 0.01 1.1e-01 -6.13 -5.9 3.7e-09 0.03 0.06 0.16 FALSE
14 GTEx Breast Mammary Tissue (Male) BCS1L 0.10 -0.01 enet 7 0.00 3.1e-01 -5.80 5.9 4.1e-09 -0.03 0.06 0.37 FALSE
15 GTEx Breast Mammary Tissue (Male) USP37 0.08 -0.01 enet 5 0.00 4.3e-01 5.34 -5.5 5.1e-08 -0.01 0.04 0.16 FALSE
16 GTEx Breast Mammary Tissue (Female) BCS1L 0.06 0.03 lasso 1 -0.01 7.1e-01 5.37 5.4 7.7e-08 -0.01 0.04 0.10 FALSE
17 GTEx Cells EBV-transformed lymphocytes TTLL4 0.16 0.09 enet 13 0.08 1.6e-03 -5.65 -5.5 4.2e-08 0.02 0.09 0.83 FALSE
18 GTEx Cells Transformed fibroblasts USP37 0.11 0.06 enet 16 0.07 4.5e-06 -6.47 -5.8 5.5e-09 0.02 0.02 0.98 FALSE
19 GTEx Cells Transformed fibroblasts RP11-316O14.1 0.19 0.16 lasso 3 0.12 1.3e-09 6.99 6.7 2.3e-11 0.03 0.00 1.00 FALSE
20 GTEx Colon Transverse CYP27A1 0.16 0.12 lasso 6 0.14 2.3e-07 -5.25 -5.7 1.5e-08 0.00 0.52 0.46 FALSE
21 GTEx Esophagus Mucosa TTLL4 0.08 0.08 enet 15 0.08 4.3e-06 5.37 -5.5 3.2e-08 0.02 0.64 0.36 FALSE
22 GTEx Esophagus Mucosa USP37 0.10 0.07 enet 42 0.06 5.6e-05 -6.13 -5.8 9.1e-09 0.00 0.08 0.91 FALSE
23 GTEx Heart Left Ventricle RQCD1 0.06 0.05 lasso 3 0.03 9.0e-03 -6.08 -6.2 5.1e-10 0.03 0.06 0.88 FALSE
24 GTEx Liver PLCD4 0.24 0.15 lasso 2 0.15 4.5e-05 -5.90 -5.9 4.6e-09 0.03 0.19 0.70 FALSE
25 GTEx Nerve Tibial TTLL4 0.15 0.13 enet 19 0.17 4.0e-12 5.54 5.5 4.8e-08 -0.02 0.57 0.43 FALSE
26 GTEx Nerve Tibial USP37 0.06 0.06 lasso 4 0.05 1.1e-04 -5.72 -6.0 1.9e-09 -0.01 0.04 0.92 FALSE
27 GTEx Prostate ABCB6 0.32 -0.01 enet 28 0.05 2.6e-02 4.49 5.1 2.9e-07 0.01 0.06 0.17 FALSE
28 GTEx Skin Not Sun Exposed Suprapubic USP37 0.11 0.01 enet 13 0.07 1.9e-04 1.45 -5.2 1.5e-07 0.08 0.11 0.70 FALSE
29 GTEx Testis CYP27A1 0.20 0.18 lasso 4 0.26 4.0e-12 5.36 -5.9 4.5e-09 0.02 0.43 0.57 FALSE
30 GTEx Thyroid BCS1L 0.07 0.00 lasso 3 0.00 6.6e-01 -5.84 5.3 1.4e-07 -0.03 0.12 0.22 FALSE
31 GTEx Thyroid PLCD4 0.08 0.10 lasso 2 0.10 3.5e-08 -5.88 -5.3 1.0e-07 0.03 0.19 0.81 FALSE
32 GTEx Thyroid USP37 0.09 0.08 lasso 8 0.06 1.8e-05 -6.19 -5.9 3.2e-09 0.00 0.07 0.93 FALSE
33 GTEx Thyroid CYP27A1 0.07 0.05 enet 23 0.04 4.8e-04 -5.58 -5.9 4.4e-09 0.04 0.44 0.50 FALSE
34 GTEx Whole Blood CYP27A1 0.03 0.05 lasso 5 0.02 1.3e-02 -5.59 -6.0 1.4e-09 0.03 0.18 0.70 FALSE
35 GTEx Whole Blood RQCD1 0.04 0.02 lasso 2 0.00 2.4e-01 -6.19 6.3 2.7e-10 -0.02 0.07 0.73 FALSE
36 GTEx Whole Blood RP11-459I19.1 0.06 0.00 enet 36 0.02 1.3e-02 -5.59 -6.0 2.2e-09 0.01 0.23 0.52 FALSE
37 METSIM Adipose CYP27A1 0.06 0.04 lasso 7 0.04 1.1e-06 -5.65 -5.8 5.5e-09 0.01 0.64 0.36 FALSE
38 NTR Blood CYP27A1 0.21 0.30 enet 44 0.31 3.8e-104 -5.65 -6.2 6.3e-10 0.02 0.61 0.39 FALSE
39 NTR Blood RQCD1 0.02 0.04 lasso 5 0.03 1.9e-11 -6.19 6.1 9.2e-10 -0.02 0.07 0.93 FALSE
40 NTR Blood USP37 0.01 0.01 blup 407 0.01 1.7e-03 -5.60 -5.6 1.9e-08 0.04 0.12 0.62 FALSE
41 ROSMAP Brain Pre-frontal Cortex PLCD4 0.05 0.04 blup 363 0.06 4.6e-08 -6.13 5.6 2.4e-08 0.00 0.06 0.94 FALSE
42 ROSMAP Brain Pre-frontal Cortex RQCD1 0.04 0.06 enet 31 0.07 3.1e-09 -5.80 -5.9 4.3e-09 0.03 0.11 0.89 FALSE
43 YFS Blood CYP27A1 0.32 0.52 lasso 16 0.53 2.9e-210 -5.56 -5.7 1.6e-08 0.02 0.62 0.38 FALSE
44 YFS Blood RQCD1 0.03 0.07 lasso 4 0.07 9.5e-21 -6.13 6.2 6.0e-10 -0.01 0.07 0.93 FALSE
45 YFS Blood TTLL4 0.02 0.02 lasso 10 0.01 6.9e-05 -5.58 -5.6 2.5e-08 0.02 0.54 0.46 FALSE
46 The Cancer Genome Atlas Colon Adenocarcinoma VIL1 0.06 0.06 blup 50 0.05 6.3e-04 -6.31 6.2 7.2e-10 -0.05 0.01 0.90 FALSE
47 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TTLL4 0.02 0.01 blup 57 0.01 1.4e-02 -5.72 -6.0 2.2e-09 0.02 0.02 0.71 FALSE
48 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DIRC3 0.12 0.01 blup 275 0.02 3.3e-03 -0.68 -5.5 4.4e-08 -0.44 0.06 0.41 TRUE
49 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma VIL1 0.02 0.01 blup 50 0.01 8.6e-03 -5.99 5.6 1.8e-08 -0.04 0.01 0.76 FALSE
50 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma TTLL4 0.03 0.04 enet 5 0.04 2.9e-03 -5.85 -5.9 3.9e-09 0.03 0.02 0.70 FALSE
51 The Cancer Genome Atlas Brain Lower Grade Glioma PLCD4 0.03 0.02 blup 61 0.02 2.1e-03 -5.88 6.1 1.1e-09 -0.03 0.03 0.89 FALSE
52 The Cancer Genome Atlas Liver Hepatocellular Carcinoma CYP27A1 0.07 0.10 lasso 2 0.09 7.3e-05 -5.25 5.4 6.9e-08 -0.02 0.02 0.94 FALSE
53 The Cancer Genome Atlas Prostate Adenocarcinoma USP37 0.02 0.02 enet 4 0.02 3.2e-03 -5.90 -6.0 2.1e-09 0.03 0.10 0.79 FALSE
54 The Cancer Genome Atlas Stomach Adenocarcinoma TTLL4 0.07 0.10 blup 57 0.09 4.9e-07 -6.08 -6.1 9.8e-10 0.00 0.02 0.98 FALSE
55 The Cancer Genome Atlas Thyroid Carcinoma DIRC3 0.08 0.06 lasso 5 0.07 2.7e-07 6.51 -6.0 2.0e-09 -0.63 0.94 0.05 TRUE
56 The Cancer Genome Atlas Thyroid Carcinoma USP37 0.05 0.03 blup 72 0.04 3.4e-05 -5.73 -6.0 1.8e-09 0.02 0.09 0.90 FALSE
57 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma USP37 0.08 0.02 blup 72 0.01 2.2e-01 -6.07 -6.2 7.8e-10 0.02 0.03 0.51 FALSE