[Hub]/) : Traits : Impedance of whole body : ← →

chr2:217,908,472-221,058,583

Best TWAS P=9.3e-13 · Best GWAS P=3.12e-15 conditioned to 0.0192

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
8	GTEx	Brain Cerebellar Hemisphere	RP11-316O14.1	0.52	0.34	lasso	4	0.35	6.1e-10	7.32	7.1	9.3e-13	0.04	0.00	1.00	TRUE
7	GTEx	Brain Cerebellar Hemisphere	RQCD1	0.13	0.04	lasso	11	0.01	2.1e-01	-6.05	-7.0	2.3e-12	0.01	0.05	0.64	TRUE
55	The Cancer Genome Atlas	Thyroid Carcinoma	DIRC3	0.08	0.06	lasso	5	0.07	2.7e-07	6.51	-6.0	2.0e-09	-0.63	0.94	0.05	TRUE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DIRC3	0.12	0.01	blup	275	0.02	3.3e-03	-0.68	-5.5	4.4e-08	-0.44	0.06	0.41	TRUE
11	GTEx	Brain Hypothalamus	RP11-316O14.1	0.28	0.26	lasso	4	0.17	8.1e-05	6.99	7.0	3.6e-12	0.04	0.01	0.98	FALSE
19	GTEx	Cells Transformed fibroblasts	RP11-316O14.1	0.19	0.16	lasso	3	0.12	1.3e-09	6.99	6.7	2.3e-11	0.03	0.00	1.00	FALSE
10	GTEx	Brain Cerebellum	RP11-316O14.1	0.39	0.29	enet	10	0.30	1.7e-09	7.10	6.4	1.3e-10	0.04	0.01	0.99	FALSE
35	GTEx	Whole Blood	RQCD1	0.04	0.02	lasso	2	0.00	2.4e-01	-6.19	6.3	2.7e-10	-0.02	0.07	0.73	FALSE
23	GTEx	Heart Left Ventricle	RQCD1	0.06	0.05	lasso	3	0.03	9.0e-03	-6.08	-6.2	5.1e-10	0.03	0.06	0.88	FALSE
9	GTEx	Brain Cerebellum	USP37	0.13	0.16	lasso	1	0.15	4.2e-05	-6.19	6.2	5.9e-10	-0.02	0.07	0.86	FALSE
44	YFS	Blood	RQCD1	0.03	0.07	lasso	4	0.07	9.5e-21	-6.13	6.2	6.0e-10	-0.01	0.07	0.93	FALSE
38	NTR	Blood	CYP27A1	0.21	0.30	enet	44	0.31	3.8e-104	-5.65	-6.2	6.3e-10	0.02	0.61	0.39	FALSE
3	GTEx	Artery Aorta	PLCD4	0.14	0.18	lasso	4	0.18	2.1e-10	-6.16	6.2	6.7e-10	-0.02	0.06	0.94	FALSE
46	The Cancer Genome Atlas	Colon Adenocarcinoma	VIL1	0.06	0.06	blup	50	0.05	6.3e-04	-6.31	6.2	7.2e-10	-0.05	0.01	0.90	FALSE
57	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	USP37	0.08	0.02	blup	72	0.01	2.2e-01	-6.07	-6.2	7.8e-10	0.02	0.03	0.51	FALSE
6	GTEx	Brain Cerebellar Hemisphere	PLCD4	0.12	0.15	lasso	2	0.07	8.9e-03	-6.13	6.1	9.0e-10	-0.02	0.07	0.68	FALSE
39	NTR	Blood	RQCD1	0.02	0.04	lasso	5	0.03	1.9e-11	-6.19	6.1	9.2e-10	-0.02	0.07	0.93	FALSE
54	The Cancer Genome Atlas	Stomach Adenocarcinoma	TTLL4	0.07	0.10	blup	57	0.09	4.9e-07	-6.08	-6.1	9.8e-10	0.00	0.02	0.98	FALSE
51	The Cancer Genome Atlas	Brain Lower Grade Glioma	PLCD4	0.03	0.02	blup	61	0.02	2.1e-03	-5.88	6.1	1.1e-09	-0.03	0.03	0.89	FALSE
34	GTEx	Whole Blood	CYP27A1	0.03	0.05	lasso	5	0.02	1.3e-02	-5.59	-6.0	1.4e-09	0.03	0.18	0.70	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	USP37	0.05	0.03	blup	72	0.04	3.4e-05	-5.73	-6.0	1.8e-09	0.02	0.09	0.90	FALSE
26	GTEx	Nerve Tibial	USP37	0.06	0.06	lasso	4	0.05	1.1e-04	-5.72	-6.0	1.9e-09	-0.01	0.04	0.92	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	USP37	0.02	0.02	enet	4	0.02	3.2e-03	-5.90	-6.0	2.1e-09	0.03	0.10	0.79	FALSE
36	GTEx	Whole Blood	RP11-459I19.1	0.06	0.00	enet	36	0.02	1.3e-02	-5.59	-6.0	2.2e-09	0.01	0.23	0.52	FALSE
47	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TTLL4	0.02	0.01	blup	57	0.01	1.4e-02	-5.72	-6.0	2.2e-09	0.02	0.02	0.71	FALSE
32	GTEx	Thyroid	USP37	0.09	0.08	lasso	8	0.06	1.8e-05	-6.19	-5.9	3.2e-09	0.00	0.07	0.93	FALSE
13	GTEx	Breast Mammary Tissue	USP37	0.20	0.02	lasso	5	0.01	1.1e-01	-6.13	-5.9	3.7e-09	0.03	0.06	0.16	FALSE
50	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TTLL4	0.03	0.04	enet	5	0.04	2.9e-03	-5.85	-5.9	3.9e-09	0.03	0.02	0.70	FALSE
14	GTEx	Breast Mammary Tissue (Male)	BCS1L	0.10	-0.01	enet	7	0.00	3.1e-01	-5.80	5.9	4.1e-09	-0.03	0.06	0.37	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	RQCD1	0.04	0.06	enet	31	0.07	3.1e-09	-5.80	-5.9	4.3e-09	0.03	0.11	0.89	FALSE
33	GTEx	Thyroid	CYP27A1	0.07	0.05	enet	23	0.04	4.8e-04	-5.58	-5.9	4.4e-09	0.04	0.44	0.50	FALSE
29	GTEx	Testis	CYP27A1	0.20	0.18	lasso	4	0.26	4.0e-12	5.36	-5.9	4.5e-09	0.02	0.43	0.57	FALSE
24	GTEx	Liver	PLCD4	0.24	0.15	lasso	2	0.15	4.5e-05	-5.90	-5.9	4.6e-09	0.03	0.19	0.70	FALSE
18	GTEx	Cells Transformed fibroblasts	USP37	0.11	0.06	enet	16	0.07	4.5e-06	-6.47	-5.8	5.5e-09	0.02	0.02	0.98	FALSE
37	METSIM	Adipose	CYP27A1	0.06	0.04	lasso	7	0.04	1.1e-06	-5.65	-5.8	5.5e-09	0.01	0.64	0.36	FALSE
22	GTEx	Esophagus Mucosa	USP37	0.10	0.07	enet	42	0.06	5.6e-05	-6.13	-5.8	9.1e-09	0.00	0.08	0.91	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PLCD4	0.06	0.09	blup	382	0.09	1.3e-10	-6.19	5.7	1.0e-08	-0.01	0.08	0.92	FALSE
20	GTEx	Colon Transverse	CYP27A1	0.16	0.12	lasso	6	0.14	2.3e-07	-5.25	-5.7	1.5e-08	0.00	0.52	0.46	FALSE
4	GTEx	Artery Aorta	USP37	0.08	0.05	lasso	4	0.04	1.7e-03	-5.67	-5.7	1.6e-08	-0.01	0.07	0.61	FALSE
43	YFS	Blood	CYP27A1	0.32	0.52	lasso	16	0.53	2.9e-210	-5.56	-5.7	1.6e-08	0.02	0.62	0.38	FALSE
5	GTEx	Artery Tibial	PLCD4	0.07	0.02	lasso	2	0.03	9.9e-04	-6.01	5.6	1.7e-08	0.00	0.07	0.91	FALSE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	VIL1	0.02	0.01	blup	50	0.01	8.6e-03	-5.99	5.6	1.8e-08	-0.04	0.01	0.76	FALSE
40	NTR	Blood	USP37	0.01	0.01	blup	407	0.01	1.7e-03	-5.60	-5.6	1.9e-08	0.04	0.12	0.62	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	PLCD4	0.05	0.04	blup	363	0.06	4.6e-08	-6.13	5.6	2.4e-08	0.00	0.06	0.94	FALSE
45	YFS	Blood	TTLL4	0.02	0.02	lasso	10	0.01	6.9e-05	-5.58	-5.6	2.5e-08	0.02	0.54	0.46	FALSE
21	GTEx	Esophagus Mucosa	TTLL4	0.08	0.08	enet	15	0.08	4.3e-06	5.37	-5.5	3.2e-08	0.02	0.64	0.36	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	TTLL4	0.16	0.09	enet	13	0.08	1.6e-03	-5.65	-5.5	4.2e-08	0.02	0.09	0.83	FALSE
12	GTEx	Breast Mammary Tissue	BCS1L	0.05	0.03	enet	7	0.03	6.8e-03	5.37	5.5	4.4e-08	-0.05	0.19	0.47	FALSE
25	GTEx	Nerve Tibial	TTLL4	0.15	0.13	enet	19	0.17	4.0e-12	5.54	5.5	4.8e-08	-0.02	0.57	0.43	FALSE
15	GTEx	Breast Mammary Tissue (Male)	USP37	0.08	-0.01	enet	5	0.00	4.3e-01	5.34	-5.5	5.1e-08	-0.01	0.04	0.16	FALSE
52	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CYP27A1	0.07	0.10	lasso	2	0.09	7.3e-05	-5.25	5.4	6.9e-08	-0.02	0.02	0.94	FALSE
16	GTEx	Breast Mammary Tissue (Female)	BCS1L	0.06	0.03	lasso	1	-0.01	7.1e-01	5.37	5.4	7.7e-08	-0.01	0.04	0.10	FALSE
2	GTEx	Adipose Subcutaneous	USP37	0.05	0.03	lasso	6	0.03	2.0e-03	-3.90	-5.3	1.0e-07	0.03	0.09	0.91	FALSE
31	GTEx	Thyroid	PLCD4	0.08	0.10	lasso	2	0.10	3.5e-08	-5.88	-5.3	1.0e-07	0.03	0.19	0.81	FALSE
30	GTEx	Thyroid	BCS1L	0.07	0.00	lasso	3	0.00	6.6e-01	-5.84	5.3	1.4e-07	-0.03	0.12	0.22	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	USP37	0.11	0.01	enet	13	0.07	1.9e-04	1.45	-5.2	1.5e-07	0.08	0.11	0.70	FALSE
27	GTEx	Prostate	ABCB6	0.32	-0.01	enet	28	0.05	2.6e-02	4.49	5.1	2.9e-07	0.01	0.06	0.17	FALSE