Hub : Genes

TTLL4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.1560	0.0610	2.7e-04	0.086	NA	0.078	NA	0.066	9.7e-04	NA	1.6e-03	NA	3.5e-03
2	GTEx	Esophagus Mucosa	0.0760	0.0320	4.4e-05	0.076	NA	0.081	NA	0.057	8.3e-06	NA	4.3e-06	NA	1.1e-04
3	GTEx	Nerve Tibial	0.1514	0.0482	2.4e-09	0.128	NA	0.170	NA	0.164	2.4e-09	NA	4.0e-12	NA	9.9e-12
4	NTR	Blood	0.0086	0.0063	2.0e-02	0.009	0.003	0.003	0.005	0.005	3.7e-04	2.7e-02	2.9e-02	0.00700	7.7e-03
5	YFS	Blood	0.0166	0.0079	1.3e-05	0.018	0.010	0.010	0.010	0.012	1.2e-06	2.1e-04	2.4e-04	0.00028	6.9e-05
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0202	0.0161	8.7e-03	0.014	0.012	0.005	NA	0.010	9.5e-03	1.4e-02	7.3e-02	NA	2.3e-02
7	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0330	0.0230	7.8e-03	0.039	0.036	0.038	NA	0.037	2.8e-03	3.9e-03	2.9e-03	NA	3.4e-03
8	TCGA	Lung Adenocarcinoma	0.0367	0.0265	3.9e-03	0.014	0.020	0.005	NA	0.008	7.2e-03	1.9e-03	8.4e-02	NA	3.3e-02
9	TCGA	Lung Squamous Cell Carcinoma	0.0385	0.0253	1.1e-04	0.043	0.032	0.024	NA	0.029	1.2e-05	1.3e-04	8.0e-04	NA	2.5e-04
10	TCGA	Stomach Adenocarcinoma	0.0700	0.0370	3.6e-06	0.100	0.090	0.087	NA	0.088	1.1e-07	4.9e-07	7.7e-07	NA	6.4e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.1	0.2	1.1	-0.2	-0.2	-0.2	-0.3	-0.7	-0.0	0.3	1.1	-0.4	0.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.9	0.3	0.2	-0.4	-0.2	-0.1	0.4	0.8	0.9	0.2	0.5
Depressed Affect (Nagel 2018)	0.2	0.4	1.1	0.7	0.1	-0.8	0.1	0.5	0.8	0.7	1.1	0.2	0.8
Depression (Nagel 2018)	0.3	0.4	1.0	0.9	0.2	-0.6	0.0	0.3	0.7	1.0	0.8	0.5	0.6
Intelligence (Savage-Jansen 2018)	0.7	2.1	4.6	-1.5	-1.7	1.0	-2.1	-1.6	-1.5	-1.3	0.4	-1.9	-0.8
Neuroticism (Nagel 2018)	0.4	1.0	1.9	-1.1	-1.4	0.6	-1.0	-1.2	-1.0	-1.0	0.1	-1.4	-0.8
Schizophrenia (2018)	0.1	0.3	0.7	0.5	0.4	-0.3	0.0	0.4	0.6	0.8	0.4	0.7	0.5
Schizophrenia vs Biploar Disorder	0.3	0.4	2.3	-0.1	0.1	0.2	0.8	0.3	-0.3	-0.2	-1.5	0.5	-0.6
Worry (Nagel 2018)	0.7	1.5	2.7	-1.5	-1.5	0.9	-1.0	-1.5	-1.2	-1.1	0.1	-1.7	-1.0
Alzheimer’s Disease (in mother)	0.9	1.1	3.5	-0.9	-0.9	0.8	-0.3	-0.6	-1.1	-1.2	-1.9	-0.4	-1.4
Alzheimer’s Disease (in father)	2.2	2.4	4.4	1.3	2.0	-2.1	1.2	1.7	1.3	1.4	0.2	1.8	1.4
Alzheimer’s Disease (including proxy)	0.4	0.6	1.4	0.6	0.8	-0.9	0.9	0.8	0.1	-0.0	-1.2	0.9	-0.0
Crohns Disease (2017)	0.3	0.8	3.1	0.8	0.0	-0.2	-0.4	0.6	1.2	1.8	0.3	1.2	0.6
Irritable Bowel Disease (IBD)	0.2	0.5	1.8	0.4	0.4	-0.2	-0.4	0.3	0.5	1.1	-1.0	1.3	-0.2
Ulcerative Colitis (UC)	0.2	0.4	2.4	-0.3	0.5	0.0	-0.6	-0.2	-0.4	-0.0	-1.5	0.6	-0.8
Major Depression (MDD)	2.8	3.4	4.3	2.1	2.0	-1.8	1.9	1.7	1.9	1.8	1.4	1.7	1.8
Reaction Time	0.2	0.4	1.0	0.5	0.1	0.2	0.9	0.6	0.7	1.0	-0.1	1.0	0.4
Verbal and Numeric Reasoning (VNR)	1.2	2.8	4.4	-1.6	-2.1	1.4	-1.9	-1.9	-1.8	-1.7	-0.2	-2.1	-1.3
Breast Cancer	0.2	0.5	0.9	-0.9	0.1	0.9	0.9	-0.8	-0.7	-0.4	-0.8	-0.2	-0.8
Ovarian Cancer	1.6	2.2	4.8	1.5	1.0	-2.2	-0.1	1.3	1.6	1.5	1.6	1.1	1.8
Prostate Cancer	0.8	1.1	6.5	-0.5	-0.2	0.7	0.3	-0.7	-0.0	-0.2	2.5	-1.5	0.9
Age at First Birth	2.0	3.0	5.2	2.1	1.7	-1.8	0.5	1.4	1.7	1.6	2.3	1.0	2.2
Bipolar Disorder (2011)	1.1	1.1	2.2	-1.0	-1.5	1.4	-1.4	-1.4	-0.8	-0.0	-0.3	-0.6	-0.8
Body Mass Index (BMI) (2010)	7.1	9.7	12.7	3.5	3.6	-3.3	2.4	3.4	3.4	3.0	2.0	3.1	3.0
Coronary Artery Disease (CAD)	0.2	0.2	0.8	-0.5	-0.5	0.9	-0.1	-0.7	-0.3	0.1	0.1	-0.2	-0.2
Crohns Disease (2012)	0.4	0.6	3.5	-0.7	-0.8	0.2	-1.9	-0.8	-0.5	0.1	-0.5	-0.2	-0.7
Mean Putamen Volume	0.2	0.2	0.6	-0.2	-0.4	0.1	0.1	-0.5	-0.4	-0.6	0.3	-0.8	-0.2
Fasting Glucose	0.6	0.7	1.2	0.8	0.6	-0.9	-0.9	1.1	0.8	0.8	0.0	1.0	0.7
HbA1C	0.4	0.5	0.8	0.5	0.9	-0.7	0.7	0.7	0.6	0.2	0.9	0.2	0.9
HDL Cholesterol	1.5	2.5	3.6	1.6	1.9	-1.8	1.1	1.5	1.6	1.8	0.7	1.9	1.4
LDL Cholesterol	0.2	0.3	1.4	-0.4	0.0	0.6	-0.1	0.0	-0.6	-0.7	-1.2	-0.0	-0.7
Lupus	0.2	0.3	0.8	-0.8	-0.4	0.1	-0.7	-0.7	-0.2	-0.1	0.9	-0.7	0.2
Neuroticism (2016)	1.5	2.1	4.6	-1.6	-1.9	2.1	-1.0	-1.6	-1.3	-1.2	-0.1	-1.7	-1.1
Primary Biliary Cirrhosis	5.0	7.2	15.0	-2.5	-2.9	2.4	-3.9	-3.0	-2.7	-2.3	-1.0	-2.7	-2.3
Rheumatoid Arthritis	0.2	0.3	1.5	-0.3	0.1	0.1	-0.8	-0.1	0.3	0.4	1.2	-0.2	0.7
Schizophrenia (2014)	0.1	0.3	1.0	0.5	0.3	-0.2	0.4	0.3	0.6	1.0	0.4	0.7	0.5
Triglycerides	4.6	7.5	10.8	-2.7	-2.6	3.2	-1.6	-3.1	-3.0	-3.3	-1.2	-3.3	-2.5
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.9	-0.6	-0.4	0.8	-0.5	-0.3	-0.8	-0.5	-0.9	-0.4	-0.9
Ulcerative Colitis	0.4	0.6	2.8	-0.3	0.5	-0.4	-1.0	-0.1	-0.3	0.1	-1.7	0.8	-0.8
Blood Eosinophil Count	0.9	6.7	12.2	-3.5	-2.2	1.8	-2.3	-2.7	-3.0	-3.0	-1.7	-2.6	-2.5
Blood Platelet Count	6.8	78.3	118.8	9.0	8.5	-9.2	9.7	8.6	9.3	10.9	3.1	10.5	7.2
Blood Red Count	15.3	147.6	178.7	-13.4	-12.9	12.1	-10.3	-13.1	-13.2	-13.3	-6.8	-13.0	-11.9
Blood White Count	0.2	1.8	7.6	-0.5	-0.5	0.7	1.6	-0.5	-0.3	-0.9	2.8	-2.0	1.2
Heel T-Score	0.1	1.1	5.5	-0.6	-1.2	1.4	-2.4	-0.9	-0.3	0.4	-0.1	-0.2	-0.6
BMI	4.7	27.5	33.1	5.1	5.6	-5.3	4.4	5.4	5.7	5.7	4.2	5.0	5.8
Height	11.9	229.0	334.9	-16.1	-14.6	14.4	-11.3	-16.8	-17.3	-18.2	-6.2	-18.3	-14.0
Waist Hip Ratio (WHR)	1.1	4.9	6.7	-2.6	-2.6	2.5	-1.6	-2.3	-2.3	-2.1	-1.2	-2.2	-2.3
Systolic Blood Pressure	0.1	0.6	1.8	1.1	0.4	-0.3	-0.8	0.3	0.7	0.7	1.4	0.2	0.9
Smoking Status	0.1	0.2	0.3	0.2	0.0	-0.4	-0.5	0.4	0.4	0.3	0.5	0.2	0.5
Allergy or Eczema	3.4	8.9	15.2	3.4	2.9	-3.9	1.3	3.0	3.2	3.1	2.2	2.9	3.2
Cardiovascular Disease	0.6	2.1	6.3	1.4	0.7	-1.1	0.7	0.9	1.5	1.8	2.5	0.6	2.0
Hypothyroidism (self reported)	4.1	9.5	14.7	3.2	3.0	-2.4	3.8	3.2	3.3	2.8	2.9	2.3	3.5
Respiratory disease	1.1	2.4	5.8	1.6	1.6	-2.4	0.8	1.7	1.4	1.5	-0.2	1.9	1.1
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	-0.2	0.1	-0.3	0.2	-0.2	-0.0	0.3	-0.3	0.2	-0.3
Lung FEV1/FVC ratio	0.2	1.2	7.1	0.9	0.1	-0.5	-0.9	0.0	0.7	0.5	2.7	-0.6	1.5
Lung FVC	1.5	7.8	11.7	2.6	3.4	-2.6	3.4	2.8	2.9	2.8	1.8	2.7	2.7
Neuroticism	0.9	2.1	3.3	-1.6	-1.8	1.3	-1.2	-1.7	-1.5	-1.5	-0.2	-1.8	-1.2
Chronotype (morning person)	4.4	10.1	14.2	-3.2	-3.1	3.8	-3.1	-3.6	-3.3	-3.2	-1.2	-3.5	-2.9
Hair Pigment	0.0	1.1	5.0	0.5	1.3	-0.2	2.2	1.1	0.8	0.6	-0.4	1.1	0.3
Tanning	0.5	6.4	9.5	2.9	2.2	-2.4	1.4	2.7	2.9	3.1	1.6	2.8	2.6
Hand grip strength (left)	2.3	6.2	12.7	-2.9	-2.6	2.5	-0.9	-2.8	-2.5	-3.1	0.4	-3.6	-1.8
Number of treatments/medications taken	1.5	2.7	4.4	1.7	1.6	-1.5	0.8	1.5	1.8	1.7	2.1	1.2	2.1
Average weekly spirits intake	1.0	1.2	3.3	1.0	1.1	-1.8	0.4	0.7	1.0	1.6	0.5	1.3	1.0
Sensitivity / hurt feelings	0.4	0.7	1.1	-1.1	-0.9	0.8	0.7	-0.9	-0.8	-0.7	-0.6	-0.7	-0.9
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.6	0.1	0.1	0.1	-0.0	-0.3	-0.1	-0.1	0.7	-0.5	0.2
Hearing difficulty/problems: Yes	0.2	0.2	0.9	0.4	0.3	-0.1	0.8	0.0	0.4	0.9	0.3	0.5	0.2
Relative age of first facial hair	2.1	4.3	5.9	2.4	2.4	-2.2	1.7	2.1	2.2	2.2	0.9	2.3	1.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.6	0.4	0.2	-0.1	0.4	0.5	0.6	0.6	1.3	0.1	1.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.4	0.1	0.4	0.0	-0.6	0.2	-0.2	-0.3	-1.2	0.4	-0.5
Ever had hysterectomy (womb removed)	1.3	1.5	2.7	-0.7	-1.4	1.1	-0.9	-1.0	-1.4	-1.6	-1.3	-1.1	-1.4
Systolic blood pressure, automated reading	1.9	5.5	9.1	3.0	2.8	-2.4	0.7	2.4	2.5	2.5	1.4	2.5	2.3
Eye problems/disorders: Diabetes related eye disease	3.5	3.9	7.5	1.6	2.2	-2.3	1.3	2.6	2.1	1.9	-0.5	2.7	1.3
Angina	0.2	0.2	1.5	-0.1	0.1	0.4	0.2	-0.2	0.0	-0.0	1.2	-0.6	0.5
Medication for hormone replacement therapy	0.7	0.8	1.5	1.1	1.2	-0.8	0.6	1.0	0.9	0.7	0.9	0.7	1.0
Vitamin and mineral supplements	0.5	0.6	2.0	-0.5	-1.0	0.4	-1.4	-1.0	-0.8	-0.6	0.1	-0.9	-0.4
Supplements: Zinc	1.6	1.8	4.2	-1.3	-0.8	1.5	0.1	-1.3	-1.5	-1.3	-2.0	-0.6	-1.8
Medication: Co-codamol	2.9	3.3	6.4	1.8	2.2	-2.5	1.6	1.9	1.8	1.8	0.5	2.0	1.4
Medication: Metformin	0.2	0.3	0.9	-0.3	0.6	-0.5	-0.1	0.2	0.1	0.5	-1.0	0.8	-0.4
Diabetes (father)	0.4	0.5	1.0	0.1	-0.0	-0.9	0.9	0.7	0.5	0.7	-0.8	1.0	-0.1
Diabetes (mother)	0.5	0.7	2.3	0.9	0.1	-0.3	1.5	0.7	0.9	1.0	0.5	0.7	0.6
Severe depression (siblings)	0.2	0.2	0.6	-0.4	-0.8	0.2	0.4	-0.4	-0.2	0.3	-0.5	0.1	-0.5
Pack years adult smoking proportion	0.1	0.1	0.4	-0.4	-0.2	0.5	0.3	0.1	-0.1	-0.4	-0.6	0.0	-0.4
Impedance of leg (right)	9.4	45.4	51.0	-6.9	-7.0	7.1	-6.7	-7.0	-7.1	-7.0	-5.0	-6.3	-7.1
Leg fat-free mass (left)	0.2	0.8	3.2	-0.3	0.2	-0.2	0.4	-0.7	-0.5	-0.9	1.8	-1.6	0.6
Trunk fat percentage	0.3	1.0	3.6	1.0	1.9	-1.4	1.1	0.8	0.6	0.5	0.3	0.8	0.8
Hand grip strength (right)	2.2	6.1	9.9	-2.9	-2.4	2.2	-1.7	-2.6	-2.7	-3.1	-0.8	-3.1	-2.2
Townsend deprivation index at recruitment	4.6	6.4	10.0	2.6	2.7	-2.1	2.2	2.8	2.8	3.1	0.9	3.2	2.3
Current tobacco smoking	0.6	1.0	1.8	1.1	1.0	-1.0	0.6	1.3	1.1	0.9	0.5	1.0	1.0
Average weekly fortified wine intake	0.5	0.6	1.2	0.7	0.8	-1.1	1.0	1.1	0.6	0.3	-0.4	0.8	0.3
Maternal smoking around birth	0.4	0.6	2.1	0.4	0.1	-0.4	1.4	0.5	0.6	0.4	1.4	-0.1	1.1
Fed-up feelings	0.1	0.3	0.7	0.4	0.2	-0.8	-0.2	0.6	0.6	0.7	-0.2	0.8	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	3.4	1.8	1.1	-1.5	0.7	1.3	1.7	1.8	1.3	1.4	1.5
Relative age voice broke	0.5	0.8	1.7	1.1	0.7	-1.3	0.1	0.9	1.0	1.0	0.1	1.1	0.5
Taking other prescription medications	4.0	6.2	8.4	2.7	2.5	-2.3	1.6	2.6	2.8	2.6	2.4	2.1	2.9
Age when periods started (menarche)	0.0	0.1	0.2	0.1	0.3	0.1	-0.5	-0.2	-0.1	-0.2	0.2	-0.3	0.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.8	0.4	0.3	-0.1	0.6	0.1	0.4	0.4	0.9	-0.0	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.1	-0.6	-0.8	1.1	-0.4	-0.7	-0.5	0.1	-0.6	-0.1	-0.7
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	1.5	1.1	1.2	-1.0	1.1	0.9	1.0	1.0	1.2	0.7	1.2
Qualifications: CSEs or equivalent	0.1	0.2	0.7	0.2	0.4	0.1	-0.0	0.4	0.2	0.2	-0.8	0.7	-0.3
Serious illness, injury or assault to yourself	1.8	2.1	3.0	1.4	1.7	-1.0	1.6	1.5	1.6	1.7	1.0	1.5	1.4
High blood pressure	3.3	9.3	14.4	3.2	2.7	-2.9	3.1	2.9	3.1	2.8	3.7	1.9	3.8
Hayfever, allergic rhinitis or eczema	1.4	3.0	6.4	2.1	1.4	-2.5	0.5	1.8	1.8	1.9	0.9	1.9	1.7
Multivitamins +/- minerals	0.6	0.7	3.7	-0.3	-0.3	0.7	1.2	0.2	-0.2	-0.1	-1.9	0.6	-1.0
Stomach or abdominal pain in last month	0.2	0.2	0.5	0.7	0.4	-0.4	-0.2	0.4	0.5	0.7	-0.0	0.7	0.2
Supplements: Glucosamine	0.1	0.1	0.4	0.6	0.2	-0.1	-0.2	0.4	0.1	-0.0	-0.1	0.1	0.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.4	0.6	0.4	-1.2	0.9	0.5	0.4	0.6	-0.7	1.0	0.2
Medication: Atenolol	0.6	0.8	2.2	-0.4	-0.8	1.1	0.0	-0.9	-0.5	-0.7	1.4	-1.5	0.2
Medication: Levothyroxine sodium	2.5	4.3	7.1	2.2	2.1	-1.6	2.7	2.2	2.1	1.8	1.9	1.5	2.4
Sitting height	5.0	35.5	51.4	-6.3	-6.2	5.9	-3.5	-6.5	-6.9	-7.2	-2.7	-7.1	-5.5
Chronic bronchitis/emphysema (father)	0.7	0.8	1.5	1.2	1.2	-1.1	0.8	0.9	0.6	0.7	0.0	1.0	0.6
High blood pressure (mother)	0.9	1.3	2.1	1.5	1.2	-1.0	1.4	1.1	1.1	0.8	1.2	0.7	1.3
Body mass index (BMI)	5.1	21.5	28.5	4.7	5.3	-5.0	4.1	4.8	4.9	4.8	3.1	4.6	4.8
Impedance of leg (left)	9.7	47.2	53.4	-7.1	-7.2	7.3	-6.4	-7.0	-7.3	-7.3	-5.1	-6.5	-7.2
Leg predicted mass (left)	0.2	0.8	3.3	-0.3	0.1	-0.2	0.3	-0.7	-0.6	-1.0	1.8	-1.6	0.5
Trunk fat mass	0.1	0.4	1.7	0.3	1.3	-0.8	0.8	0.2	-0.0	-0.3	0.7	-0.3	0.5
Waist circumference	0.5	2.0	4.6	1.2	2.1	-1.6	1.4	1.3	1.2	1.1	1.3	0.9	1.5
Number of incorrect matches in round	0.4	0.6	2.2	-0.8	-0.3	0.6	-0.4	-0.8	-0.7	-0.2	-1.5	0.2	-1.1
Past tobacco smoking	0.0	0.0	0.1	0.2	-0.1	0.3	0.0	-0.1	0.0	0.1	0.1	-0.0	0.0
Alcohol usually taken with meals	2.9	4.7	8.1	-2.8	-1.8	1.9	-1.6	-2.0	-2.5	-2.5	-1.7	-2.1	-2.2
Nervous feelings	0.0	0.0	0.2	0.1	-0.5	-0.2	-0.0	-0.1	0.0	0.2	-0.3	0.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.5	-0.9	-1.6	0.7	-1.4	-1.2	-0.9	-0.7	-0.1	-1.1	-0.7
Hearing difficulty/problems with background noise	0.8	1.3	2.5	-1.2	-1.6	1.3	-0.2	-1.2	-1.3	-0.8	-1.1	-0.8	-1.3
Hair/balding pattern: Pattern 2	0.3	0.4	1.8	-0.1	0.1	0.2	-0.9	-0.2	-0.4	-0.2	-1.4	0.4	-0.8
Had menopause	0.3	0.4	1.2	0.3	0.9	-0.5	0.3	0.5	0.3	0.5	-1.1	1.1	-0.2
Had other major operations	0.4	0.5	1.0	0.7	1.0	-0.8	0.0	1.0	0.7	0.4	0.3	0.7	0.7
Forced vital capacity (FVC)	3.1	11.9	21.9	-4.0	-3.6	3.5	-1.9	-4.0	-3.7	-3.9	-0.0	-4.7	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.3	3.4	-0.9	-1.7	1.9	-1.0	-1.4	-0.8	-0.3	0.4	-1.2	-0.7
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.5	0.1	-0.5	0.2	-0.5	-0.1	-0.0	-0.3	0.7	-0.5	0.3
Qualifications: None of the above	5.0	10.6	14.3	3.2	3.8	-2.8	2.3	2.9	3.7	3.8	3.5	2.7	3.6
Financial difficulties in last 2 years	0.1	0.1	0.4	-0.1	0.2	-0.1	0.1	-0.2	-0.5	-0.6	-0.6	-0.2	-0.4
Mouth/teeth dental problems	8.2	12.5	21.2	-3.9	-3.4	2.3	-2.4	-3.5	-4.2	-4.6	-3.2	-3.5	-3.7
Heart attack	1.4	1.8	4.8	-1.2	-1.8	2.2	-0.7	-1.5	-1.1	-0.9	0.5	-1.7	-0.7
Allergy	2.1	4.8	9.3	-2.6	-2.0	3.0	-0.9	-2.5	-2.2	-2.3	-0.4	-2.6	-1.9
Pain all over the body in last month	0.1	0.2	0.9	0.2	-0.2	-0.1	-0.2	-0.0	0.3	0.4	1.0	-0.1	0.5
Diabetes (self-reported)	0.4	0.6	1.6	0.3	1.0	-0.9	0.3	0.6	0.5	0.9	-0.9	1.3	-0.1
Hayfever/allergic rhinitis (self-reported)	1.8	2.3	4.0	2.0	1.2	-1.9	0.9	1.4	1.7	1.7	1.2	1.5	1.5
Medication: Ramipril	1.1	1.4	2.7	1.0	1.1	-1.2	1.1	1.1	1.1	1.6	0.1	1.6	0.9
Medication: Simvastatin	0.1	0.1	0.5	-0.2	-0.2	-0.2	-0.7	-0.2	0.0	0.4	0.2	0.1	0.1
Fluid intelligence score	1.3	2.7	5.5	-1.6	-2.2	1.0	-2.4	-1.7	-1.5	-1.5	0.1	-2.0	-1.2
Illnesses of siblings	0.7	0.9	1.5	0.8	0.6	-1.2	1.0	1.2	1.2	1.1	0.3	1.1	0.8
Neuroticism score	0.7	1.5	2.5	-1.2	-1.6	1.2	-0.9	-1.4	-1.2	-1.1	-0.8	-1.1	-1.4
Weight	0.1	0.4	1.6	-0.1	0.7	-0.5	0.5	-0.2	-0.3	-0.6	1.3	-1.0	0.5
Impedance of arm (right)	2.5	11.8	16.6	-3.4	-3.0	3.3	-2.4	-3.4	-3.9	-4.0	-3.4	-3.1	-4.1
Arm fat percentage (right)	3.0	11.7	18.7	3.5	4.3	-3.8	3.4	3.6	3.4	3.2	1.8	3.4	3.2
Trunk fat-free mass	1.5	8.9	22.7	-3.0	-2.6	2.7	-1.9	-3.3	-3.2	-3.8	1.3	-4.8	-1.4
Hip circumference	0.3	1.5	4.4	1.0	2.1	-1.6	0.9	0.9	0.7	0.1	1.6	0.0	1.4
Time employed in main current job	2.9	3.3	5.0	1.9	2.1	-2.0	1.2	1.9	1.8	1.6	1.8	1.4	2.2
Alcohol intake versus 10 years previously	0.2	0.3	1.0	-0.2	0.3	0.0	-0.5	0.3	0.8	1.0	0.9	0.5	0.6
Father’s age at death	4.1	5.5	9.2	2.6	2.9	-2.4	2.2	3.0	2.4	1.9	0.3	2.6	2.0
Worrier / anxious feelings	0.8	1.5	2.8	-1.5	-1.5	1.0	-0.8	-1.7	-1.2	-0.9	0.2	-1.6	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	-0.2	-0.8	0.4	-0.4	-0.3	0.0	0.0	0.6	-0.4	0.2
Falls in the last year	0.5	0.7	1.7	0.7	0.7	-1.0	0.6	1.1	0.7	0.7	-0.8	1.3	0.2
Hair/balding pattern: Pattern 3	0.9	1.3	3.2	-1.1	-1.3	-1.0	-1.8	-0.8	-1.1	-1.3	-0.8	-1.0	-0.8
Number of live births	0.1	0.2	1.2	0.3	0.3	-0.4	-1.1	0.3	0.1	0.1	-0.5	0.5	-0.1
Forced expiratory volume in 1-second (FEV1)	2.1	7.1	14.8	-3.0	-2.7	2.5	-1.6	-3.2	-2.8	-2.9	0.7	-3.9	-1.7
Pulse rate	0.2	0.3	1.1	-0.6	-0.1	0.2	0.2	-0.4	-0.5	-0.2	-1.0	0.1	-0.7
Happiness	0.1	0.1	0.3	-0.5	-0.5	0.4	-0.1	-0.3	-0.2	-0.2	0.4	-0.5	-0.0
Noisy workplace	1.3	1.7	3.5	1.1	1.9	-0.7	1.5	0.8	1.2	1.5	1.2	1.2	1.3
Qualifications: A levels/AS levels or equivalent	6.8	15.0	19.4	-4.1	-4.4	3.6	-3.3	-3.7	-4.3	-4.4	-2.9	-3.9	-3.9
Serious illness, injury or assault of a close relative in last 2 years	3.1	3.6	7.7	2.0	2.2	-2.8	1.6	2.1	1.8	1.6	0.4	2.0	1.5
Mouth/teeth dental problems: Dentures	5.4	9.1	15.0	3.1	3.1	-1.6	2.3	2.8	3.5	3.4	3.9	2.1	3.6
Asthma	0.6	1.1	3.2	1.1	0.7	-1.8	0.6	1.3	0.8	0.8	-0.8	1.4	0.5
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	2.9	-1.4	-1.3	1.2	-0.8	-1.5	-1.6	-1.7	-1.1	-1.5	-1.5
Medication: Cholesterol lowering	0.6	0.9	1.3	-1.0	-1.0	1.0	-0.5	-1.1	-1.1	-0.8	-0.6	-0.9	-1.0
Depression (self-reported)	1.1	1.3	3.4	-0.8	-1.9	1.2	-1.2	-1.0	-0.9	-0.6	-1.4	-0.5	-1.4
Medication: Lansoprazole	0.7	0.8	2.2	-0.6	-0.2	0.8	-1.0	-1.0	-0.7	-1.0	1.1	-1.5	-0.1
Prospective memory result	0.2	0.2	0.9	0.0	0.2	-0.2	0.3	0.3	0.2	0.2	-1.0	0.7	-0.3
Lung cancer (father)	0.3	0.3	0.8	0.4	-0.1	-0.1	0.8	0.4	0.7	0.7	0.9	0.3	0.7
Illnesses of mother	1.1	1.4	3.9	-1.3	-0.9	1.1	-1.2	-0.4	-1.0	-1.1	-2.0	-0.3	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.0	13.1	-2.7	-2.3	2.5	-1.7	-3.0	-2.5	-2.8	0.9	-3.6	-1.4
Pulse wave Arterial Stiffness index	5.0	5.9	8.1	-2.8	-2.7	2.0	-1.4	-2.5	-2.6	-2.5	-2.5	-2.0	-2.8
Impedance of arm (left)	2.3	10.8	16.1	-3.2	-2.9	3.0	-2.6	-3.3	-3.7	-3.6	-3.7	-2.6	-4.0
Arm fat mass (right)	1.5	6.0	9.7	2.4	3.1	-2.9	2.4	2.3	2.3	2.2	2.1	1.9	2.6
Trunk predicted mass	1.6	9.2	23.3	-3.1	-2.7	2.8	-1.9	-3.4	-3.2	-3.8	1.4	-4.8	-1.4
Standing height	9.3	92.2	139.2	-10.1	-9.5	9.3	-7.3	-10.5	-10.9	-11.6	-3.6	-11.8	-8.6
Length of working week for main job	0.6	0.7	1.7	1.2	0.6	-0.6	0.6	0.5	0.8	0.8	1.3	0.3	1.0
Exposure to tobacco smoke at home	1.3	1.5	2.5	1.0	1.1	-1.0	0.6	1.5	1.6	1.5	0.5	1.6	1.1
Breastfed as a baby	1.3	1.6	2.8	-1.4	-1.0	1.5	-0.6	-1.4	-1.5	-1.6	-0.2	-1.7	-0.9
Tense / ‘highly strung’	0.6	1.0	1.7	-1.3	-1.2	0.9	-0.9	-1.3	-1.0	-0.9	0.1	-1.3	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.3	-0.6	0.5	-0.3	-0.6	-0.4	-0.1	-0.2	-0.3	-0.4
Hair/balding pattern: Pattern 4	0.5	1.1	6.0	-0.0	0.0	-2.2	-2.5	-0.1	-0.2	0.2	-0.4	0.3	-0.1
Birth weight of first child	0.2	0.4	1.6	0.2	-0.5	0.4	-1.3	-0.6	-0.2	-0.3	1.0	-0.8	0.1
Peak expiratory flow (PEF)	0.5	1.2	3.3	-1.2	-0.9	0.7	-0.9	-1.3	-1.0	-0.9	1.4	-1.8	-0.1
Pulse wave reflection index	7.9	9.8	15.1	-3.5	-3.9	3.1	-2.0	-3.3	-3.3	-3.3	-2.2	-3.1	-3.2
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.0	-0.3	-0.9	0.7	-1.4	-0.7	-0.3	-0.6	0.7	-1.0	-0.1
Loud music exposure frequency	0.1	0.2	1.0	0.4	0.1	-0.3	1.0	0.0	-0.1	-0.5	0.2	-0.3	0.0
Qualifications: O levels/GCSEs or equivalent	4.9	7.7	13.0	-3.0	-3.0	2.5	-1.6	-2.8	-3.3	-3.6	-1.3	-3.4	-2.5
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.6	0.6	-0.0	-0.2	0.5	0.8	0.9	1.6	-0.8	1.6	0.1
Blood clot in the leg (DVT)	0.6	0.8	3.1	0.7	0.6	-0.6	-0.4	0.5	0.8	0.7	1.8	0.0	1.3
Medication: Paracetamol	0.6	1.0	2.2	-0.9	-1.0	1.2	-1.0	-1.0	-0.8	-1.1	0.6	-1.5	-0.3
Headache pain in last month	0.2	0.3	0.8	-0.2	-0.7	0.9	-0.7	-0.5	-0.3	-0.4	-0.0	-0.5	-0.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.7	-0.8	-1.2	0.9	-1.3	-0.6	-0.7	-0.8	-1.1	-0.5	-1.1
Glaucoma (self-reported)	0.1	0.1	0.4	-0.4	-0.3	0.5	-0.6	-0.3	-0.1	0.0	0.3	-0.3	0.0
Gout (self-reported)	0.8	1.1	2.5	0.9	0.5	-0.8	1.4	1.1	1.1	0.7	1.6	0.2	1.4
Hypothyroidism/myxoedema (self-reported)	4.7	9.1	11.4	3.2	3.2	-2.4	3.3	3.2	3.2	2.8	2.7	2.4	3.4
Medication: Amlodipine	4.7	6.6	9.1	2.5	2.6	-2.1	3.0	2.5	2.7	2.6	2.4	2.1	2.9
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.7	1.3	0.6	-1.0	0.1	1.0	0.9	0.9	-0.3	1.3	0.5
Birth weight	0.0	0.0	0.1	-0.2	0.1	-0.0	-0.3	-0.1	0.0	0.1	0.3	-0.1	0.2
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.3	1.1	1.1	-0.9	1.4	1.2	1.4	1.2	1.5	0.8	1.5
High blood pressure (siblings)	0.5	0.7	1.9	-0.7	-0.6	1.4	-0.5	-0.8	-0.9	-1.0	0.2	-1.1	-0.4
Forced vital capacity (FVC), Best measure	2.4	8.6	17.4	-3.2	-2.9	3.0	-1.9	-3.4	-3.1	-3.5	0.3	-4.2	-2.1
Body fat percentage	0.6	2.4	5.9	1.6	2.4	-1.9	1.6	1.5	1.3	1.2	0.5	1.5	1.3
Leg fat percentage (right)	0.8	2.7	5.9	1.6	2.4	-2.0	1.1	1.7	1.6	1.6	0.6	1.8	1.4
Arm fat-free mass (right)	1.0	4.9	11.6	-2.3	-2.1	1.8	-1.7	-2.5	-2.4	-2.7	0.7	-3.4	-1.2
Exposure to tobacco smoke outside home	0.5	0.7	1.5	0.9	1.0	-1.1	0.5	0.7	0.8	0.3	1.2	0.2	1.0
Comparative body size at age 10	5.8	16.0	20.5	4.0	4.0	-3.8	4.1	4.1	4.3	4.0	3.8	3.2	4.5
Number of full brothers	0.3	0.4	1.4	0.1	-0.8	1.2	0.1	-0.5	0.0	-0.1	1.0	-0.7	0.2
Worry too long after embarrassment	7.6	12.7	20.3	-3.7	-3.2	3.4	-1.9	-3.5	-4.0	-3.8	-4.4	-2.6	-4.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.8	0.9	0.7	-0.8	1.3	0.7	1.0	0.9	1.3	0.5	1.1
Wheeze or whistling in the chest in last year	1.2	2.2	4.5	1.8	1.1	-1.1	0.5	1.2	1.8	2.1	1.4	1.5	1.5
Number of children fathered	0.3	0.4	1.8	0.6	0.1	-0.1	0.7	0.2	0.5	0.5	1.3	-0.1	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	5.3	-1.4	-1.4	1.2	-1.0	-1.2	-1.7	-1.4	-2.3	-0.7	-1.9
Age at first live birth	2.1	3.8	5.2	-1.9	-2.3	1.8	-1.9	-1.6	-2.0	-1.9	-2.2	-1.4	-2.3
Pulse wave peak to peak time	2.3	2.7	4.3	1.9	1.9	-1.3	0.7	1.7	1.7	1.5	2.1	1.1	2.1
Health satisfaction	0.4	0.5	1.6	-0.6	-0.6	0.8	-1.3	-0.5	-0.5	-0.5	-0.7	-0.2	-0.7
Shortness of breath walking on level ground	0.2	0.3	0.6	0.2	0.8	-0.4	0.5	0.6	0.5	0.4	0.3	0.5	0.6
Qualifications: College or University degree	1.8	5.6	8.2	-2.7	-2.8	1.6	-2.0	-2.1	-2.7	-2.9	-1.9	-2.4	-2.3
Eye problems/disorders: None of the above	0.4	0.4	1.0	-0.5	-0.3	0.3	0.2	-0.7	-0.9	-1.0	-0.8	-0.6	-0.8
Mouth/teeth dental problems: Loose teeth	3.2	3.8	5.6	-2.0	-2.4	2.4	-1.6	-1.9	-1.9	-1.8	-1.5	-1.8	-2.1
Emphysema/chronic bronchitis	0.8	0.9	4.5	0.4	0.2	0.1	-0.3	0.2	0.0	0.8	-2.1	1.5	-0.9
Medication for pain relief, constipation, heartburn	0.2	0.3	0.8	0.4	0.4	-0.7	0.5	0.6	0.4	0.5	-0.6	0.9	0.1
Neck or shoulder pain in last month	1.1	1.5	3.9	1.4	1.0	-0.9	0.1	1.0	1.4	2.0	0.7	1.6	1.2
Medication: Blood pressure	3.7	6.5	10.2	2.5	2.6	-2.1	3.2	2.2	2.4	2.2	3.1	1.5	3.1
Angina (self-reported)	0.2	0.2	1.2	-0.2	0.0	0.5	0.2	-0.2	0.0	-0.1	1.1	-0.6	0.4
Migraine (self-reported)	0.7	0.8	1.5	-0.7	-1.2	1.1	-0.6	-1.0	-0.9	-1.0	-0.4	-1.0	-0.8
Medication: Ibuprofen	0.4	0.5	1.1	-0.8	-0.4	0.3	-0.4	-0.6	-0.8	-1.0	-0.6	-0.8	-0.8
Medication: Allopurinol	0.3	0.4	1.8	0.3	0.5	-0.7	1.4	0.6	0.6	0.5	0.5	0.4	0.6
Medication: Omeprazole	3.1	3.7	5.1	-1.8	-2.0	1.6	-2.2	-2.0	-2.1	-1.9	-1.6	-1.7	-2.1
Medication: Seretide 50 evohaler	1.4	1.6	3.2	1.3	0.9	-1.4	0.5	1.4	1.4	1.8	0.2	1.8	1.0
Mean time to correctly identify matches	0.4	0.8	1.7	1.0	0.7	-0.2	0.8	1.1	1.0	1.1	-0.2	1.3	0.7
Heart disease (mother)	1.5	1.9	10.2	0.6	0.7	-1.1	1.2	0.0	0.8	0.9	3.2	-0.6	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.9	0.4	0.3	-1.4	-1.0	0.4	0.6	0.7	0.7	0.4	0.6
Whole body fat mass	0.3	1.3	3.5	1.0	1.9	-1.4	1.3	0.9	0.8	0.5	1.1	0.4	1.2
Leg fat mass (right)	0.5	1.9	4.1	1.3	2.0	-1.6	1.3	1.2	1.2	1.0	1.3	0.9	1.5
Arm predicted mass (right)	1.0	5.0	12.7	-2.3	-2.0	1.8	-1.6	-2.6	-2.4	-2.7	1.0	-3.6	-1.1
Pulse rate, automated reading	1.7	5.4	8.6	-2.5	-2.6	2.3	-1.4	-2.3	-2.5	-1.9	-2.9	-1.4	-2.9
Alcohol intake frequency.	1.2	2.7	6.9	1.7	1.2	-0.9	1.9	1.3	1.8	1.5	2.6	0.5	2.1
Comparative height size at age 10	8.7	47.8	75.5	-7.3	-6.6	6.7	-5.3	-7.7	-7.9	-8.3	-2.2	-8.7	-6.1
Number of full sisters	1.0	1.2	1.9	1.0	1.3	-0.8	1.2	0.9	1.2	1.4	0.9	1.1	1.1
Suffer from ‘nerves’	0.1	0.2	0.9	-0.3	-0.9	-0.1	-0.4	-0.5	0.0	0.2	0.6	-0.4	0.0
Overall health rating	1.4	3.0	4.5	2.0	1.9	-1.1	0.7	1.8	2.1	1.9	1.9	1.5	2.0
Chest pain or discomfort	0.2	0.3	1.0	-0.3	-1.0	0.3	-0.4	-0.8	-0.5	-0.2	0.4	-0.8	-0.3
Had major operations	0.3	0.3	1.2	-0.2	-0.1	0.6	-1.1	-0.4	-0.2	-0.1	0.9	-0.6	0.2
Age at last live birth	1.0	1.5	6.7	-1.1	-1.1	0.2	-1.0	-0.4	-1.0	-0.9	-2.6	0.1	-1.7
Family relationship satisfaction	0.3	0.4	0.7	-0.7	-0.8	0.6	0.0	-0.4	-0.7	-0.7	-0.8	-0.4	-0.6
Leg pain on walking	0.8	1.0	2.7	0.9	1.3	-1.7	0.6	1.0	0.8	0.9	0.1	1.1	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.9	-0.2	-1.4	1.0	-0.8	-0.4	-0.6	-0.4	-0.7	-0.3	-0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.8	0.5	-0.2	-0.4	-0.2	0.2	0.4	0.2	1.3	-0.3	0.8
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	3.5	-1.6	-1.6	1.9	-1.2	-1.4	-1.5	-1.5	-1.1	-1.4	-1.4
Medication: Aspirin	0.4	0.5	1.8	0.5	0.5	-0.4	0.2	0.5	0.8	0.8	1.3	0.2	1.0
Supplements: Vitamin C	0.8	1.0	2.9	0.5	1.7	-0.9	1.0	0.8	0.6	0.1	1.6	-0.0	1.3
Knee pain experienced in last month	1.0	1.5	2.4	1.5	1.6	-1.2	0.5	1.3	1.2	0.8	1.4	0.7	1.5
Hypertension (Self-reported)	4.5	12.4	16.6	3.7	3.3	-3.6	3.6	3.5	3.7	3.4	3.4	2.7	4.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.1	-0.6	-0.6	0.7	-0.9	-1.1	-0.9	-0.8	-0.5	-0.7	-0.9
Illnesses of father: Heart disease	2.6	3.5	4.8	-1.7	-2.1	1.6	-2.2	-2.2	-2.0	-1.8	-1.1	-1.9	-2.0
Illnesses of siblings: Diabetes	0.2	0.2	0.6	0.4	0.6	0.1	0.7	-0.3	0.0	0.3	0.8	-0.1	0.4
Smoking status: Previous	0.1	0.2	0.7	0.2	0.2	-0.8	0.1	0.3	0.4	0.5	0.3	0.4	0.3
Forced expiratory volume in 1-second (FEV1), predicted	5.5	11.5	16.9	-3.4	-3.7	3.2	-3.4	-3.6	-3.6	-4.0	-0.9	-4.1	-2.8
Whole body fat-free mass	0.8	4.4	12.9	-2.0	-1.6	1.6	-1.0	-2.4	-2.2	-2.7	1.5	-3.6	-0.7
Leg fat-free mass (right)	0.2	0.9	3.2	-0.4	0.1	-0.2	0.6	-0.7	-0.6	-1.0	1.8	-1.7	0.6
Arm fat percentage (left)	3.2	12.9	20.0	3.7	4.5	-4.0	3.6	3.7	3.6	3.5	1.8	3.6	3.4
Average weekly red wine intake	0.1	0.2	0.4	-0.2	0.3	-0.1	-0.6	0.4	-0.0	-0.2	0.7	-0.3	0.6
Handedness (chirality/laterality): Left-handed	2.7	3.2	5.1	-2.1	-1.9	1.8	-1.4	-2.1	-2.0	-1.9	-0.3	-2.2	-1.5
Mood swings	0.3	0.6	2.3	-0.5	-0.9	1.1	-1.5	-0.7	-0.3	-0.1	0.2	-0.5	-0.3
Loneliness, isolation	1.5	2.0	4.0	2.0	1.1	-1.6	1.1	1.5	1.6	1.5	0.6	1.5	1.3
Long-standing illness, disability or infirmity	3.1	4.8	8.6	2.4	2.1	-2.3	1.2	2.1	2.4	2.9	1.1	2.7	2.0
Ever had bowel cancer screening	0.2	0.2	0.5	0.3	0.2	-0.6	-0.3	0.3	0.4	0.7	0.2	0.5	0.5
Diabetes diagnosed by doctor	0.3	0.5	1.3	0.3	0.8	-1.1	0.4	0.6	0.5	0.8	-0.7	1.1	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	3.1	3.3	5.4	-1.7	-1.9	2.3	-1.9	-1.6	-1.8	-1.6	-1.9	-1.2	-2.1
Friendships satisfaction	0.5	0.6	1.3	-0.9	-1.1	0.5	-0.9	-0.8	-0.7	-0.4	-0.8	-0.4	-0.9
Qualifications: nursing, teaching	0.6	0.9	2.1	-0.8	-1.5	0.6	-0.5	-0.4	-0.9	-1.1	-1.4	-0.5	-1.0
Commuting to job workplace: Walk	0.3	0.4	2.1	-0.3	0.3	-0.3	-0.1	0.4	-0.3	-0.6	-1.4	0.4	-0.6
Eye problems/disorders: Cataract	0.7	0.8	3.1	0.8	0.5	-0.7	0.1	0.8	1.0	0.6	1.8	0.1	1.3
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.1	1.6	0.7	-0.7	0.7	1.2	1.2	1.5	-0.4	1.8	0.5
Medication for cholesterol	3.3	5.0	7.0	-2.5	-1.9	2.0	-1.5	-2.2	-2.5	-2.6	-2.0	-2.1	-2.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	9.0	10.6	12.2	3.4	3.3	-3.5	3.2	3.5	3.4	3.3	2.3	3.1	3.4
Back pain experienced in last month	0.2	0.2	0.5	0.6	0.2	-0.1	-0.5	0.7	0.6	0.4	0.2	0.5	0.5
Mineral and other dietary supplements	0.1	0.2	0.6	-0.5	-0.1	-0.5	-0.3	-0.5	-0.0	0.4	0.7	-0.3	0.2
Breast cancer (self-reported)	0.2	0.3	0.8	-0.6	0.0	0.7	-0.9	-0.6	-0.6	-0.5	-0.2	-0.4	-0.4
Asthma (self-reported)	0.7	1.5	3.6	1.3	0.9	-1.9	0.9	1.6	1.0	0.9	-0.7	1.6	0.7
Osteoporosis (self-reported)	1.3	1.6	2.5	1.5	0.9	-1.0	0.4	1.3	1.6	1.6	1.4	1.2	1.6
Osteoarthritis (self-reported)	2.4	3.1	5.2	1.9	2.3	-1.9	1.3	1.6	1.8	1.7	1.6	1.4	1.8
Medication: Aspirin	0.2	0.2	1.2	0.2	0.3	-0.1	-0.0	0.3	0.5	0.5	1.1	0.0	0.7
Medication: Gliclazide	0.1	0.1	0.5	-0.5	0.1	-0.3	-0.0	0.1	-0.1	-0.2	-0.7	0.2	-0.4
Illnesses of father: None of the above (group 1)	1.6	2.0	3.3	-1.6	-1.5	1.8	-0.9	-1.5	-1.5	-1.2	-1.1	-1.1	-1.5
Smoking status: Current	0.4	0.6	1.3	0.9	0.7	-0.8	0.4	1.2	0.9	0.6	0.2	0.9	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.7	-0.6	-0.4	0.9	-0.3	-1.0	-0.5	-0.7	1.1	-1.3	-0.2
Whole body water mass	0.7	3.8	11.6	-1.9	-1.4	1.4	-1.0	-2.2	-2.0	-2.5	1.6	-3.4	-0.5
Leg predicted mass (right)	0.2	0.9	3.5	-0.3	0.1	-0.2	0.6	-0.7	-0.5	-1.0	1.9	-1.7	0.6
Arm fat mass (left)	1.7	7.0	11.2	2.6	3.4	-3.2	2.5	2.5	2.6	2.5	2.1	2.2	2.8
Number of self-reported non-cancer illnesses	2.2	3.8	6.1	2.5	1.7	-2.1	0.9	2.0	2.2	2.2	1.5	1.9	2.1
Average weekly champagne plus white wine intake	1.5	2.1	5.5	-1.1	-1.5	0.6	-0.6	-1.0	-1.6	-1.7	-2.4	-0.8	-2.0
Miserableness	0.1	0.1	0.2	0.4	0.3	-0.5	0.4	0.4	0.4	0.2	0.4	0.2	0.5
Guilty feelings	0.3	0.5	0.9	-0.5	-0.8	0.2	-1.0	-0.8	-0.7	-0.7	0.2	-0.9	-0.4
Wears glasses or contact lenses	0.6	0.6	2.4	0.5	0.7	-0.2	1.0	0.5	0.0	0.6	-1.6	1.3	-0.3
Ever taken oral contraceptive pill	3.9	4.4	6.8	-2.5	-2.6	2.2	-1.1	-2.4	-2.3	-2.0	-0.7	-2.3	-1.9
Hearing aid user	2.6	2.9	4.4	1.8	1.8	-1.9	1.7	2.1	1.7	1.7	0.1	2.0	1.4
Mother’s age at death	1.3	1.7	3.6	1.2	1.6	-1.9	1.1	1.5	1.1	0.9	0.5	1.2	1.3
Financial situation satisfaction	1.3	1.6	3.5	-1.4	-0.9	1.2	-0.4	-0.9	-1.3	-1.5	-1.9	-0.7	-1.6
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.1	-0.6	-0.5	0.3	-0.1	-1.0	-0.7	-0.1	-1.1	-0.1	-1.0
Commuting to job workplace: Public transport	0.5	0.5	1.1	-0.6	-0.3	0.1	-0.1	-0.7	-1.0	-1.0	-1.1	-0.6	-1.0
Eye problems/disorders: Glaucoma	0.9	1.0	2.2	-1.2	-1.0	0.9	-1.5	-1.2	-1.0	-0.8	-0.3	-1.0	-0.9
Medication: Blood pressure	1.4	2.6	4.0	1.4	1.2	-1.6	1.3	1.7	1.9	2.0	1.4	1.6	1.9
Pain type(s) experienced in last month: Hip pain	2.2	2.8	6.5	1.8	1.3	-1.5	1.4	1.2	1.7	1.7	2.5	0.7	2.1
Supplements: Fish oil (including cod liver oil)	0.2	0.2	1.0	-0.2	-0.1	0.6	0.0	0.0	-0.3	-0.5	-1.0	0.1	-0.6
High cholesterol (Self-reported)	1.0	1.8	3.7	-1.1	-1.5	0.9	-1.5	-1.5	-1.3	-0.6	-1.9	-0.3	-1.8
Medication: Bendroflumethiazide	5.8	8.8	12.8	3.1	2.5	-3.1	2.3	3.0	3.2	3.1	3.1	2.3	3.6
Medication: Paracetamol	0.3	0.4	0.7	-0.8	-0.7	0.9	-0.7	-0.6	-0.5	-0.7	0.2	-0.9	-0.3
Medication: Lisinopril	0.4	0.5	1.1	-1.0	-0.6	0.4	-0.1	-0.7	-0.9	-1.1	-0.1	-1.0	-0.4
Medication: Atorvastatin	0.5	0.7	2.1	-0.2	-1.1	1.5	-0.4	-0.9	-0.7	-0.7	-0.1	-0.9	-0.7
Illnesses of father: High blood pressure	1.4	1.7	2.7	1.5	1.1	-1.3	0.6	1.6	1.6	1.4	0.9	1.3	1.3
Alcohol drinker status: Never	0.7	0.8	4.8	0.2	-0.1	0.8	0.5	-0.1	0.3	-0.2	2.2	-1.2	0.8
Ever smoked	0.0	0.0	0.2	-0.2	0.1	-0.5	0.1	0.2	0.1	-0.0	-0.2	0.2	-0.0
Basal metabolic rate	0.6	3.1	9.6	-1.7	-1.1	1.2	-0.8	-2.0	-1.9	-2.3	1.5	-3.1	-0.5
Leg fat percentage (left)	0.9	3.1	6.2	1.7	2.5	-2.1	1.6	1.9	1.7	1.6	0.7	1.9	1.6
Arm fat-free mass (left)	0.9	4.5	11.5	-2.3	-1.8	1.7	-1.6	-2.5	-2.3	-2.6	1.1	-3.4	-1.0
Number of operations (self-reported)	3.0	4.5	6.3	2.2	2.4	-1.8	0.9	2.3	2.4	2.2	2.1	1.9	2.5
Average weekly beer plus cider intake	0.2	0.4	0.9	0.5	0.4	-0.1	-0.0	0.6	0.8	0.6	0.9	0.4	0.8
Irritability	0.4	0.6	3.6	-0.6	-0.7	0.5	-1.9	-0.7	-0.4	-0.2	-0.1	-0.4	-0.5
Risk taking	0.0	0.0	0.2	-0.0	-0.3	-0.2	0.1	-0.1	0.1	0.3	0.4	-0.0	0.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.0	-1.4	-0.8	0.8	-0.4	-0.5	-0.8	-0.9	-0.7	-0.6	-0.7
Fractured/broken bones in last 5 years	0.1	0.1	0.4	-0.3	0.1	-0.2	-0.2	-0.3	-0.4	0.0	-0.6	0.1	-0.5
Age started oral contraceptive pill	0.0	0.0	0.1	0.1	-0.3	-0.3	-0.2	0.0	-0.1	0.2	-0.3	0.2	-0.1
Diastolic blood pressure, automated reading	1.0	3.0	8.4	-0.8	-1.3	1.6	-2.0	-1.7	-0.8	-1.2	2.9	-2.7	0.4
Ever depressed for a whole week	0.6	0.8	1.5	-0.8	-1.1	0.9	-0.6	-1.0	-0.9	-1.0	0.1	-1.2	-0.6
Unable to work because of sickness or disability	6.3	8.1	14.0	3.1	2.8	-2.6	2.9	3.3	3.0	3.1	0.2	3.7	2.3
Commuting to job workplace: Cycle	0.7	0.9	2.9	-0.8	-0.9	1.0	-1.7	-0.8	-0.8	-0.4	-1.0	-0.3	-1.0
Myopia	0.4	0.6	1.6	1.0	0.9	-1.3	-0.0	0.9	0.4	0.4	-0.6	1.1	0.4
Vascular/heart problems diagnosed by doctor	3.0	8.0	14.7	-2.9	-2.5	2.5	-3.0	-2.6	-2.8	-2.4	-3.8	-1.4	-3.7
Cholesterol lowering medication	0.3	0.5	1.8	0.6	0.0	-0.5	-0.7	0.3	0.7	1.4	-0.0	1.1	0.3
Medication: Omeprazole (e.g. Zanprol)	3.5	4.2	5.5	-2.1	-2.2	1.8	-2.1	-2.3	-2.4	-2.0	-1.6	-1.9	-2.1
Pain experienced in last month	0.2	0.3	2.0	0.1	0.0	-0.4	1.4	0.4	0.3	0.4	0.2	0.3	0.3
Supplements: Calcium	1.0	1.0	2.4	1.1	1.3	-0.7	1.5	0.9	0.9	1.0	0.1	1.2	0.7
Basal cell carcinoma (self-reported)	1.3	1.6	3.2	1.4	1.6	-1.4	1.8	1.2	1.1	0.9	0.6	1.1	1.1
Heart attack/myocardial infarction (self-reported)	1.2	1.6	4.7	-1.1	-1.7	2.2	-0.5	-1.4	-1.1	-0.8	0.2	-1.4	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.8	0.6	0.5	-0.4	-0.4	0.4	0.7	0.6	1.7	-0.1	1.1
Heart disease (siblings)	0.6	0.8	2.8	0.7	0.9	-0.9	-0.9	0.1	0.7	0.8	1.7	0.1	1.0
Alcohol drinker status: Previous	0.1	0.1	0.4	0.5	0.2	-0.1	0.7	0.2	0.3	0.4	0.2	0.2	0.3
Pack years of smoking	0.2	0.2	0.6	-0.7	-0.4	0.7	0.0	-0.2	-0.3	-0.5	-0.6	-0.2	-0.5
Impedance of whole body	5.9	30.0	37.3	-5.5	-5.5	5.5	-4.8	-5.6	-6.0	-5.9	-4.9	-4.9	-6.1
Leg fat mass (left)	0.6	2.3	4.5	1.4	2.1	-1.8	1.6	1.4	1.3	1.1	1.5	0.9	1.7
Arm predicted mass (left)	0.9	4.5	11.5	-2.2	-1.8	1.8	-1.6	-2.4	-2.3	-2.6	1.1	-3.4	-0.9