TWAS hub - VIL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Colon Adenocarcinoma	0.0630	0.0370	0.0030	0.059	0.051	0.028	NA	0.044	0.00027	0.00062	0.0091	NA	0.0015
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0209	0.0137	0.0077	0.010	0.014	0.001	NA	0.009	0.02100	0.00860	0.2600	NA	0.0270

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Red Count	12.4	119.7	136.2	10.2	11.7
Height	11.8	227.8	262.4	13.9	16.2
Worry too long after embarrassment	9.9	16.5	18.3	4.3	3.8
Impedance of leg (left)	9.8	47.7	48.3	6.9	7.0
Body Mass Index (BMI) (2010)	9.5	13.0	13.7	-3.5	-3.7
Standing height	9.5	94.2	108.2	9.0	10.4
Impedance of leg (right)	8.7	42.1	42.9	6.4	6.5
Mouth/teeth dental problems	8.2	12.6	13.5	3.4	3.7
Medication: Bendroflumethiazide	8.2	12.4	13.1	-3.6	-3.4
Comparative height size at age 10	7.6	42.0	53.0	5.6	7.3
Qualifications: A levels/AS levels or equivalent	7.5	16.6	19.5	3.7	4.4
Impedance of whole body	6.8	34.8	37.9	6.2	5.6
Comparative body size at age 10	6.7	18.5	19.1	-4.2	-4.4
Mouth/teeth dental problems: Dentures	6.4	10.7	11.2	-3.4	-3.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	6.4	7.5	7.7	-2.7	-2.8
Sitting height	6.3	44.9	53.3	6.0	7.3
Ever taken oral contraceptive pill	6.3	7.0	7.1	2.7	2.6
Body mass index (BMI)	6.1	25.8	29.6	-4.7	-5.4
Qualifications: O levels/GCSEs or equivalent	6.1	9.8	10.7	3.0	3.3
Allergy or Eczema	6.0	15.9	16.1	-4.0	-4.0
Hypothyroidism/myxoedema (self-reported)	6.0	11.6	13.9	-3.7	-3.1
Qualifications: None of the above	5.9	12.7	14.1	-3.4	-3.8
Blood Platelet Count	5.6	64.6	92.4	-6.1	-9.6
Mouth/teeth dental problems: Loose teeth	5.6	6.7	8.1	2.9	2.3
BMI	5.4	31.0	35.9	-5.1	-6.0
Taking other prescription medications	5.2	8.0	9.0	-3.0	-2.6
Number of operations (self-reported)	5.0	7.4	12.5	-3.5	-1.5
Hypothyroidism (self reported)	4.9	11.2	11.3	-3.4	-3.3
Pulse wave reflection index	4.9	6.0	8.2	1.9	2.9
Forced expiratory volume in 1-second (FEV1), predicted	4.8	10.0	12.9	2.6	3.6
Triglycerides	4.4	7.2	8.4	2.9	2.5
Financial situation satisfaction	4.4	5.5	6.3	2.5	2.2
Unable to work because of sickness or disability	4.2	5.4	7.7	-2.8	-1.8
Medication for cholesterol	4.1	6.2	7.0	2.3	2.6
Supplements: Zinc	4.0	4.3	5.8	2.4	1.7
Hypertension (Self-reported)	4.0	11.0	12.9	-3.0	-3.6
Medication: Omeprazole	3.8	4.6	4.7	2.2	2.1
Medication: Amlodipine	3.6	5.0	6.4	-1.9	-2.5
Arm fat percentage (left)	3.6	14.4	18.4	-3.2	-4.3
High blood pressure	3.5	9.8	12.1	-2.8	-3.5
Arm fat percentage (right)	3.4	13.3	16.7	-3.1	-4.1
Medication: Omeprazole (e.g. Zanprol)	3.4	4.2	5.0	1.8	2.2
Chronotype (morning person)	3.3	7.7	9.1	3.0	2.5
Hayfever, allergic rhinitis or eczema	3.3	7.2	7.5	-2.6	-2.7
Impedance of arm (right)	3.3	15.6	17.8	4.2	3.7
Time employed in main current job	3.2	3.7	5.2	-2.3	-1.4
Impedance of arm (left)	3.2	14.9	17.7	4.2	3.5
Heart disease (mother)	3.2	3.9	4.0	-2.0	-1.9
Alcohol usually taken with meals	3.1	5.1	7.1	1.8	2.7
Ovarian Cancer	3.0	3.9	4.8	-1.7	-2.2
Hayfever/allergic rhinitis (self-reported)	3.0	3.9	4.5	-1.8	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	3.0	3.2	3.5	1.7	1.9
Average weekly champagne plus white wine intake	3.0	4.1	4.7	1.9	2.2
Vascular/heart problems diagnosed by doctor	3.0	8.3	10.7	2.4	3.3
Age at First Birth	2.9	4.2	4.5	-1.9	-2.1
Hand grip strength (right)	2.9	7.9	9.2	2.6	3.0
Number of self-reported non-cancer illnesses	2.9	5.0	5.3	-2.1	-2.3
Pulse wave Arterial Stiffness index	2.8	3.3	3.5	1.7	1.9
Eye problems/disorders: Cataract	2.8	3.3	4.2	-2.1	-1.5
Osteoporosis (self-reported)	2.8	3.5	4.2	-2.0	-1.7
Alzheimer’s Disease (in mother)	2.7	3.1	3.8	1.6	2.0
Medication: Levothyroxine sodium	2.7	4.5	5.1	-2.2	-2.0
Allergy	2.7	6.2	6.9	2.3	2.6
Alzheimer’s Disease (in father)	2.6	2.9	3.0	-1.7	-1.7
Forced vital capacity (FVC)	2.6	9.9	13.2	2.6	3.6
Noisy workplace	2.5	3.1	3.5	-1.7	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	2.5	2.9	3.8	1.4	1.9
Medication: Blood pressure	2.5	4.4	6.1	-1.6	-2.5
Medication: Blood pressure	2.5	4.7	4.8	-2.2	-2.1
Long-standing illness, disability or infirmity	2.4	3.7	4.9	-1.6	-2.2
Arm fat mass (left)	2.4	9.9	11.7	-2.8	-3.4
Number of treatments/medications taken	2.3	4.1	4.1	-2.0	-2.0
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	3.8	-1.0	-2.0
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.6	3.1	-1.5	-1.8
Depression (self-reported)	2.3	2.7	2.9	1.7	1.6
Pain type(s) experienced in last month: Hip pain	2.3	2.9	3.8	-1.9	-1.4
Crohns Disease (2017)	2.2	4.8	5.1	-2.1	-2.3
Arm fat mass (right)	2.2	9.0	10.9	-2.7	-3.3
Eye problems/disorders: None of the above	2.2	2.5	3.7	1.9	1.2
Townsend deprivation index at recruitment	2.1	2.9	3.6	-1.5	-1.9
Hearing difficulty/problems with background noise	2.1	3.3	3.4	1.8	1.9
Neck or shoulder pain in last month	2.1	2.9	3.5	-1.9	-1.5
Osteoarthritis (self-reported)	2.1	2.7	2.8	-1.7	-1.6
Major Depression (MDD)	2.0	2.4	2.6	-1.5	-1.6
Systolic blood pressure, automated reading	1.9	5.5	7.1	-2.0	-2.7
Hand grip strength (left)	1.8	4.7	6.6	1.7	2.6
Neuroticism score	1.8	3.8	4.4	1.8	2.1
Forced vital capacity (FVC), Best measure	1.8	6.7	10.1	1.8	3.2
Illnesses of father: None of the above (group 1)	1.8	2.2	2.3	1.5	1.4
Medication: Co-codamol	1.7	2.0	2.3	-1.3	-1.5
Medication: Ramipril	1.7	2.2	3.9	-0.6	-2.0
Family relationship satisfaction	1.7	2.1	2.7	1.2	1.6
Illnesses of father: High blood pressure	1.7	2.1	2.1	-1.4	-1.5
Neuroticism (2016)	1.6	2.3	3.5	1.9	1.1
Average weekly spirits intake	1.6	2.0	2.5	-1.6	-1.2
Pulse rate, automated reading	1.6	5.3	5.7	2.2	2.4
Relative age of first facial hair	1.5	3.1	3.4	-1.7	-1.8
Commuting to job workplace: Public transport	1.5	1.8	2.5	1.6	1.1
Ever depressed for a whole week	1.5	1.8	2.2	1.2	1.5
Heart disease (siblings)	1.5	1.9	2.2	-1.5	-1.2
Father’s age at death	1.4	1.9	2.7	-1.6	-1.1
Forced expiratory volume in 1-second (FEV1)	1.4	4.8	6.7	1.7	2.6
Qualifications: College or University degree	1.4	4.3	5.2	1.8	2.3
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	2.1	1.4	1.2
Hearing aid user	1.4	1.6	3.1	-1.8	-0.3
Cholesterol lowering medication	1.4	2.0	2.3	-1.5	-1.3
HbA1C	1.3	1.4	1.5	-1.1	-1.2
LDL Cholesterol	1.3	2.0	2.6	1.6	1.2
Primary Biliary Cirrhosis	1.3	1.8	2.5	1.0	1.6
Respiratory disease	1.3	2.9	4.3	-1.2	-2.1
Lung FVC	1.3	6.7	8.9	-3.0	-2.1
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	2.1	-1.4	-0.9
High cholesterol (Self-reported)	1.3	2.3	3.4	1.9	1.1
Pack years of smoking	1.3	1.8	2.5	1.6	1.1
Sensitivity / hurt feelings	1.2	2.0	3.2	1.8	0.9
Ever had hysterectomy (womb removed)	1.2	1.4	1.7	1.0	1.3
Medication: Cholesterol lowering	1.2	1.8	3.0	1.7	0.8
Age at first live birth	1.2	2.1	2.8	1.7	1.2
Illnesses of father: Heart disease	1.2	1.7	1.9	1.4	1.2
Waist Hip Ratio (WHR)	1.1	4.7	7.6	2.8	1.4
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.5	1.5	1.2	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.6	5.6	1.3	2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.2	-0.6	-1.5
Age at last live birth	1.1	1.6	1.7	1.3	1.2
Pack years adult smoking proportion	1.0	1.5	2.0	1.4	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	1.7	-1.3	-0.9
High blood pressure (mother)	1.0	1.4	1.4	-1.2	-1.1
Hair/balding pattern: Pattern 3	1.0	1.5	2.6	0.7	1.6
Illnesses of mother	1.0	1.2	1.9	0.8	1.4
Leg fat percentage (right)	1.0	3.7	5.2	-1.5	-2.3
Handedness (chirality/laterality): Left-handed	1.0	1.2	1.6	1.3	0.9
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.1	0.5	1.4
Heart attack/myocardial infarction (self-reported)	1.0	1.3	1.8	1.3	0.9
Neuroticism	0.9	2.1	2.8	1.1	1.7
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.1	0.3	1.4
Multivitamins +/- minerals	0.9	1.1	1.8	1.3	0.7
Financial difficulties in last 2 years	0.9	1.3	1.3	1.1	1.1
Heart attack	0.9	1.1	1.6	1.3	0.8
Lung cancer (father)	0.9	1.0	1.2	-1.1	-0.9
Gout (self-reported)	0.9	1.2	1.9	-0.7	-1.4
Chronic bronchitis/emphysema (mother)	0.9	1.0	1.8	-0.5	-1.3
Exposure to tobacco smoke outside home	0.9	1.2	1.5	-0.9	-1.2
Medication: Seretide 50 evohaler	0.9	1.1	1.4	-1.2	-0.9
Overall health rating	0.9	2.0	2.2	-1.5	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.0	1.4	0.4
Mother’s age at death	0.9	1.1	1.7	-1.3	-0.7
Leg fat percentage (left)	0.9	3.4	4.9	-1.4	-2.2
HDL Cholesterol	0.8	1.4	1.9	-1.4	-0.9
Cardiovascular Disease	0.8	2.6	4.0	-1.1	-2.0
Serious illness, injury or assault to yourself	0.8	1.0	1.6	-0.7	-1.3
Alcohol intake versus 10 years previously	0.8	1.2	2.4	-0.3	-1.5
Happiness	0.8	1.0	1.7	0.5	1.3
Trunk predicted mass	0.8	4.4	7.2	1.2	2.7
Hair/balding pattern: Pattern 4	0.8	1.9	3.6	-1.9	-0.5
Wheeze or whistling in the chest in last year	0.8	1.4	2.4	-0.7	-1.5
Migraine (self-reported)	0.8	0.9	1.5	1.2	0.6
Leg fat mass (right)	0.8	3.1	4.2	-1.5	-2.0
Commuting to job workplace: Walk	0.8	0.9	1.3	0.7	1.1
Breast cancer (self-reported)	0.8	1.0	1.4	0.8	1.2
Medication: Lisinopril	0.8	1.1	1.7	1.3	0.7
Leg fat mass (left)	0.8	3.3	4.4	-1.5	-2.1
Verbal and Numeric Reasoning (VNR)	0.7	1.8	2.2	1.2	1.5
Tanning	0.7	8.4	10.5	-3.2	-2.5
Number of incorrect matches in round	0.7	1.1	1.2	1.0	1.1
Had other major operations	0.7	0.9	1.6	-1.3	-0.3
Trunk fat-free mass	0.7	4.3	7.1	1.2	2.7
Blood clot in the leg (DVT)	0.7	0.9	1.0	-0.8	-1.0
Body fat percentage	0.7	2.8	4.7	-1.0	-2.2
Pulse wave peak to peak time	0.7	0.9	0.9	-0.9	-1.0
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.2	-1.1	-0.6
Friendships satisfaction	0.7	0.9	1.5	0.5	1.2
Mineral and other dietary supplements	0.7	0.9	1.1	-0.8	-1.1
Average weekly beer plus cider intake	0.7	1.0	1.0	-1.0	-1.0
Schizophrenia vs Biploar Disorder	0.6	0.8	1.4	1.2	0.5
Crohns Disease (2012)	0.6	0.9	1.0	-1.0	-0.9
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.2	1.1	0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.1	-1.0	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	1.9	1.4	0.9
Length of working week for main job	0.6	0.7	0.9	-0.6	-0.9
Tense / ‘highly strung’	0.6	1.0	1.6	0.6	1.3
Alcohol intake frequency.	0.6	1.5	2.5	-0.7	-1.6
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.3	0.6	1.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.0	-0.8	-1.0
Worry (Nagel 2018)	0.5	1.1	1.8	0.6	1.3
Ulcerative Colitis (UC)	0.5	1.0	1.6	1.2	0.6
Fasting Glucose	0.5	0.5	0.6	-0.8	-0.7
Lupus	0.5	0.8	1.4	-1.2	-0.4
Medication for hormone replacement therapy	0.5	0.5	0.6	-0.8	-0.6
Chronic bronchitis/emphysema (father)	0.5	0.6	1.0	-1.0	-0.4
Waist circumference	0.5	1.8	2.8	-0.9	-1.7
Exposure to tobacco smoke at home	0.5	0.6	0.8	-0.7	-0.9
Arm fat-free mass (right)	0.5	2.3	3.7	1.0	1.9
Health satisfaction	0.5	0.6	0.8	0.7	0.9
Medication: Ibuprofen	0.5	0.6	0.9	1.0	0.5
Whole body fat mass	0.5	1.9	2.9	-1.0	-1.7
Guilty feelings	0.5	0.8	1.1	1.0	0.8
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.6	0.8	0.7
Basal cell carcinoma (self-reported)	0.5	0.6	0.7	-0.8	-0.8
Depression (Nagel 2018)	0.4	0.6	1.1	-1.1	-0.3
Severe depression (siblings)	0.4	0.5	1.0	1.0	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.2	1.1	0.6
Pain all over the body in last month	0.4	0.4	0.5	-0.5	-0.7
Fluid intelligence score	0.4	0.8	1.4	0.4	1.2
Illnesses of siblings	0.4	0.5	0.8	-0.6	-0.9
Worrier / anxious feelings	0.4	0.7	1.0	1.0	0.7
Pulse rate	0.4	0.7	1.0	1.0	0.6
Breastfed as a baby	0.4	0.4	0.6	0.5	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.9	0.6	0.9
Birth weight of first child	0.4	0.7	1.2	-1.1	-0.5
Medication: Paracetamol	0.4	0.6	1.2	-0.1	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.8	-0.9	-0.5
Number of children fathered	0.4	0.4	0.6	-0.5	-0.8
Medication: Allopurinol	0.4	0.5	0.7	-0.6	-0.8
Arm predicted mass (right)	0.4	1.9	3.1	0.9	1.8
Number of full sisters	0.4	0.5	0.9	-0.4	-1.0
Leg pain on walking	0.4	0.5	0.6	-0.7	-0.8
Qualifications: nursing, teaching	0.4	0.6	1.0	0.3	1.0
Medication: Atorvastatin	0.4	0.5	0.7	0.9	0.5
Neuroticism (Nagel 2018)	0.3	0.7	1.0	0.6	1.0
Mean Putamen Volume	0.3	0.3	0.4	-0.6	-0.5
Ulcerative Colitis	0.3	0.5	0.9	0.9	0.3
Blood Eosinophil Count	0.3	2.4	4.7	0.3	2.2
Blood White Count	0.3	2.6	5.2	-2.3	-0.2
Systolic Blood Pressure	0.3	1.4	2.5	-0.5	-1.6
Trunk fat percentage	0.3	1.4	2.6	-0.4	-1.6
Stomach or abdominal pain in last month	0.3	0.4	0.6	-0.4	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	0.1	1.0
Medication: Simvastatin	0.3	0.5	0.9	-0.2	-1.0
Asthma	0.3	0.6	0.7	-0.6	-0.9
Loud music exposure frequency	0.3	0.3	0.6	0.8	0.2
Mean time to correctly identify matches	0.3	0.5	0.9	-0.9	-0.5
Medication: Aspirin	0.3	0.3	0.6	-0.2	-0.8
Knee pain experienced in last month	0.3	0.5	1.0	-0.2	-1.0
Whole body fat-free mass	0.3	1.6	2.7	0.7	1.6
Average weekly red wine intake	0.3	0.5	0.7	-0.8	0.5
Loneliness, isolation	0.3	0.4	0.6	-0.7	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.0	-0.3	-1.0
Back pain experienced in last month	0.3	0.5	0.5	-0.7	-0.7
Asthma (self-reported)	0.3	0.6	0.7	-0.6	-0.9
Medication: Paracetamol	0.3	0.4	0.9	0.0	0.9
Arm fat-free mass (left)	0.3	1.5	2.5	0.7	1.6
Commuting to job workplace: Cycle	0.3	0.3	0.6	-0.2	0.8
Arm predicted mass (left)	0.3	1.5	2.8	0.5	1.7
Depressed Affect (Nagel 2018)	0.2	0.4	0.6	-0.8	-0.4
Intelligence (Savage-Jansen 2018)	0.2	0.6	0.9	0.6	0.9
Irritable Bowel Disease (IBD)	0.2	0.5	0.9	-0.4	-0.9
Reaction Time	0.2	0.3	0.6	-0.8	-0.3
Breast Cancer	0.2	0.4	0.5	0.7	0.5
Prostate Cancer	0.2	0.3	0.3	-0.6	-0.5
Rheumatoid Arthritis	0.2	0.3	0.5	-0.7	-0.2
Lung FEV1/FVC ratio	0.2	1.1	1.2	-1.0	-1.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	0.2	0.8
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.4	-0.6	-0.5
Vitamin and mineral supplements	0.2	0.3	0.5	-0.7	0.2
Average weekly fortified wine intake	0.2	0.2	0.4	-0.6	-0.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.5	0.2	-0.7
Medication: Atenolol	0.2	0.2	0.2	-0.4	0.5
Hip circumference	0.2	1.0	1.1	-1.0	-0.9
Headache pain in last month	0.2	0.3	0.4	0.7	0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.6	-0.4	0.8
Glaucoma (self-reported)	0.2	0.2	0.3	0.3	0.5
High blood pressure (siblings)	0.2	0.3	0.6	0.3	0.8
Smoking status: Previous	0.2	0.3	0.6	-0.0	-0.8
Whole body water mass	0.2	1.2	2.1	0.4	1.5
Ever smoked	0.2	0.3	0.5	0.7	0.1
Diastolic blood pressure, automated reading	0.2	0.5	0.5	-0.7	-0.7
Myopia	0.2	0.3	0.4	-0.7	-0.3
Smoking Status	0.1	0.1	0.3	0.2	-0.5
Medication: Metformin	0.1	0.2	0.2	-0.5	-0.2
Diabetes (father)	0.1	0.1	0.3	0.5	0.1
Maternal smoking around birth	0.1	0.2	0.3	0.5	-0.3
Relative age voice broke	0.1	0.2	0.4	0.1	-0.7
Trunk fat mass	0.1	0.4	0.8	-0.2	-0.9
Past tobacco smoking	0.1	0.3	0.5	-0.7	0.1
Nervous feelings	0.1	0.2	0.3	-0.1	0.5
Had menopause	0.1	0.1	0.2	0.5	-0.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.1	0.5
Diabetes (self-reported)	0.1	0.2	0.2	-0.3	-0.5
Falls in the last year	0.1	0.2	0.4	0.0	-0.6
Prospective memory result	0.1	0.1	0.2	0.5	0.0
Peak expiratory flow (PEF)	0.1	0.3	0.6	0.3	0.8
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.0	-0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.2	-0.5	-0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.2	-0.3	-0.5
Shortness of breath walking on level ground	0.1	0.1	0.1	-0.2	-0.4
Suffer from ‘nerves’	0.1	0.1	0.2	-0.5	0.1
Had major operations	0.1	0.2	0.3	-0.6	-0.2
Supplements: Vitamin C	0.1	0.1	0.1	-0.0	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.4	-0.1
Ever had bowel cancer screening	0.1	0.2	0.3	-0.0	-0.6
Diabetes diagnosed by doctor	0.1	0.1	0.3	-0.2	-0.5
Medication: Gliclazide	0.1	0.1	0.2	0.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.3	-0.5	-0.2
Wears glasses or contact lenses	0.1	0.1	0.3	0.5	0.1
Eye problems/disorders: Glaucoma	0.1	0.2	0.3	0.2	0.5
Alcohol drinker status: Never	0.1	0.1	0.1	-0.4	-0.1
Basal metabolic rate	0.1	0.8	1.4	0.4	1.2
Irritability	0.1	0.1	0.2	-0.3	0.5
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.4	0.2
Age started oral contraceptive pill	0.1	0.1	0.1	-0.3	0.2
Pain experienced in last month	0.1	0.1	0.2	-0.5	-0.1
Alcohol drinker status: Previous	0.1	0.1	0.2	0.2	0.5
Bipolar Disorder (2018)	0.0	0.0	0.1	-0.1	-0.2
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	0.0	-0.5
Schizophrenia (2018)	0.0	0.1	0.2	0.1	-0.4
Alzheimer’s Disease (including proxy)	0.0	0.0	0.0	0.1	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.1	0.1	-0.3
Schizophrenia (2014)	0.0	0.1	0.1	-0.1	-0.3
Heel T-Score	0.0	0.3	0.6	-0.7	-0.2
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	-0.1	-0.4
Hair Pigment	0.0	0.1	0.2	-0.4	-0.2
Hearing difficulty/problems: Yes	0.0	0.0	0.1	-0.3	0.0
Angina	0.0	0.0	0.1	0.2	-0.2
Diabetes (mother)	0.0	0.1	0.1	-0.1	-0.3
Leg fat-free mass (left)	0.0	0.1	0.2	-0.4	-0.2
Current tobacco smoking	0.0	0.0	0.1	-0.1	-0.2
Fed-up feelings	0.0	0.1	0.1	0.3	0.3
Age when periods started (menarche)	0.0	0.0	0.1	0.2	-0.3
Qualifications: CSEs or equivalent	0.0	0.0	0.0	0.1	0.0
Supplements: Glucosamine	0.0	0.0	0.0	0.1	0.2
Leg predicted mass (left)	0.0	0.1	0.2	-0.4	-0.2
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	-0.1	0.1
Weight	0.0	0.1	0.2	-0.3	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.1	0.1	0.3
Number of live births	0.0	0.0	0.0	0.0	0.0
Medication: Lansoprazole	0.0	0.1	0.1	0.3	-0.1
Birth weight	0.0	0.0	0.1	-0.3	-0.1
Number of full brothers	0.0	0.0	0.1	-0.1	-0.2
Emphysema/chronic bronchitis	0.0	0.0	0.0	0.2	0.1
Medication for pain relief, constipation, heartburn	0.0	0.0	0.0	0.1	-0.2
Angina (self-reported)	0.0	0.0	0.1	0.3	-0.2
Chest pain or discomfort	0.0	0.0	0.0	-0.1	-0.2
Illnesses of siblings: Diabetes	0.0	0.0	0.1	0.2	-0.1
Leg fat-free mass (right)	0.0	0.0	0.1	-0.3	0.0
Mood swings	0.0	0.0	0.0	0.2	0.2
Medication: Aspirin	0.0	0.0	0.1	0.1	-0.2
Smoking status: Current	0.0	0.0	0.0	0.2	-0.1
Leg predicted mass (right)	0.0	0.1	0.1	-0.4	-0.0
Miserableness	0.0	0.1	0.1	-0.1	0.3
Risk taking	0.0	0.0	0.0	0.1	-0.2
Supplements: Calcium	0.0	0.0	0.1	0.3	-0.2

Hub : Genes

VIL1

Models

Trait associations