Best TWAS P=2.03e-10 · Best GWAS P=3.39e-10 conditioned to 0.00636
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RNF215 | 0.03 | 0.00 | blup | 442 | 0.00 | 1.9e-01 | -3.0 | -5.2 | 2.0e-07 | 0.12 | 0.01 | 0.12 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | KREMEN1 | 0.19 | 0.13 | enet | 22 | 0.13 | 9.2e-11 | 5.0 | 5.9 | 3.2e-09 | 0.05 | 0.19 | 0.81 | TRUE |
| 3 | GTEx | Breast Mammary Tissue | KREMEN1 | 0.14 | 0.06 | enet | 10 | 0.10 | 6.9e-06 | 4.4 | 5.4 | 7.8e-08 | 0.07 | 0.26 | 0.62 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | SFI1 | 0.15 | 0.07 | lasso | 3 | 0.06 | 3.7e-03 | -5.5 | 6.1 | 8.4e-10 | -0.93 | 0.04 | 0.82 | FALSE |
| 5 | GTEx | Esophagus Muscularis | LIMK2 | 0.08 | 0.03 | lasso | 4 | 0.01 | 4.3e-02 | -5.5 | 5.4 | 6.4e-08 | -0.84 | 0.05 | 0.85 | FALSE |
| 6 | GTEx | Heart Left Ventricle | SFI1 | 0.12 | 0.10 | enet | 20 | 0.07 | 2.3e-04 | 4.7 | 5.1 | 2.9e-07 | -0.67 | 0.06 | 0.93 | FALSE |
| 7 | GTEx | Muscle Skeletal | SFI1 | 0.13 | 0.09 | enet | 22 | 0.10 | 1.7e-10 | 4.7 | 5.9 | 3.3e-09 | -0.70 | 0.44 | 0.56 | FALSE |
| 8 | GTEx | Nerve Tibial | SFI1 | 0.23 | 0.06 | enet | 16 | 0.14 | 1.9e-10 | -4.7 | 5.3 | 9.3e-08 | -0.75 | 0.33 | 0.67 | FALSE |
| 9 | GTEx | Pancreas | KREMEN1 | 0.33 | 0.24 | lasso | 7 | 0.23 | 4.2e-10 | 5.0 | 5.3 | 1.5e-07 | 0.03 | 0.18 | 0.82 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | CCDC117 | 0.07 | 0.03 | enet | 11 | 0.03 | 2.8e-03 | 3.2 | -5.7 | 1.2e-08 | -0.03 | 0.12 | 0.46 | FALSE |
| 11 | NTR | Blood | DEPDC5 | 0.02 | 0.02 | lasso | 5 | 0.01 | 2.4e-05 | -6.1 | 6.4 | 2.0e-10 | -0.60 | 0.01 | 0.99 | TRUE |
| 12 | NTR | Blood | PISD | 0.05 | 0.08 | lasso | 5 | 0.09 | 3.3e-27 | -6.1 | 5.3 | 9.1e-08 | -0.52 | 0.02 | 0.98 | FALSE |
| 13 | YFS | Blood | EIF4ENIF1 | 0.01 | 0.00 | blup | 362 | 0.01 | 9.7e-04 | 6.2 | 5.2 | 2.3e-07 | -0.47 | 0.02 | 0.64 | FALSE |
| 14 | YFS | Blood | PISD | 0.36 | 0.32 | lasso | 9 | 0.35 | 5.1e-122 | -6.1 | 5.5 | 2.9e-08 | -0.64 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Colon Adenocarcinoma | RNF185 | 0.08 | 0.05 | blup | 54 | 0.08 | 1.8e-05 | -6.3 | -5.4 | 7.8e-08 | 0.85 | 0.01 | 0.99 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | KREMEN1 | 0.13 | 0.10 | lasso | 5 | 0.11 | 3.3e-12 | 4.6 | 5.4 | 5.7e-08 | 0.01 | 0.66 | 0.33 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LIMK2 | 0.06 | 0.06 | blup | 47 | 0.06 | 9.3e-08 | -4.7 | 5.6 | 2.8e-08 | -0.91 | 0.07 | 0.93 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RNF185 | 0.06 | 0.05 | blup | 54 | 0.05 | 4.7e-06 | -6.1 | -5.2 | 1.6e-07 | 0.82 | 0.00 | 0.99 | FALSE |
| 19 | The Cancer Genome Atlas | Rectum Adenocarcinoma | RNF185 | 0.18 | 0.10 | enet | 6 | 0.12 | 9.7e-04 | -6.1 | -5.7 | 9.1e-09 | 0.95 | 0.00 | 0.88 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | RNF185 | 0.06 | 0.09 | lasso | 4 | 0.07 | 1.5e-07 | -6.3 | -6.2 | 5.8e-10 | 1.00 | 0.00 | 1.00 | FALSE |