[Hub]/) : Traits : Leg fat mass (right) :

chr8:8,092,025-12,751,157

Best TWAS P=2.37e-11 · Best GWAS P=2.57e-10 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FAM86B1 0.02 0.02 lasso 3 0.01 1.3e-02 5.3 5.4 7.0e-08 0.55 0.02 0.93 FALSE
2 GTEx Adipose Subcutaneous ERI1 0.05 0.00 enet 10 0.00 5.5e-01 3.5 -5.5 3.3e-08 -0.49 0.24 0.31 FALSE
3 GTEx Adipose Subcutaneous AF131215.2 0.24 0.15 lasso 7 0.14 3.5e-11 -5.3 5.6 2.1e-08 0.62 0.48 0.52 FALSE
4 GTEx Adipose Subcutaneous FAM85A 0.06 0.06 enet 10 0.07 3.3e-06 -5.0 5.6 2.7e-08 0.38 0.03 0.95 TRUE
5 GTEx Adipose Visceral Omentum AF131215.2 0.12 0.08 lasso 6 0.06 4.6e-04 5.6 5.7 1.4e-08 0.65 0.27 0.69 FALSE
6 GTEx Adipose Visceral Omentum AF131215.9 0.18 0.16 lasso 7 0.16 2.0e-08 5.6 5.8 6.2e-09 0.64 0.15 0.85 FALSE
7 GTEx Adrenal Gland FAM86B3P 0.16 0.00 enet 18 0.03 2.2e-02 4.6 -5.8 6.2e-09 -0.33 0.07 0.17 FALSE
8 GTEx Adrenal Gland AF131215.2 0.20 0.16 enet 12 0.13 2.2e-05 5.7 6.1 1.0e-09 0.65 0.08 0.92 FALSE
9 GTEx Adrenal Gland AF131215.9 0.18 0.16 lasso 10 0.18 3.5e-07 5.7 6.1 9.3e-10 0.66 0.08 0.91 TRUE
10 GTEx Artery Aorta ERI1 0.11 0.08 lasso 5 0.10 5.1e-06 5.2 -5.2 2.5e-07 -0.54 0.19 0.80 FALSE
11 GTEx Artery Aorta AF131215.2 0.09 0.09 lasso 7 0.08 2.0e-05 -5.3 5.9 2.9e-09 0.68 0.13 0.86 FALSE
12 GTEx Artery Aorta FAM85A 0.11 0.06 enet 19 0.06 3.4e-04 -5.1 5.4 7.4e-08 0.48 0.03 0.95 FALSE
13 GTEx Artery Aorta AF131215.9 0.13 0.05 lasso 6 0.07 1.3e-04 6.0 6.1 1.1e-09 0.66 0.06 0.94 FALSE
14 GTEx Artery Coronary AF131215.2 0.11 0.02 enet 27 0.05 6.5e-03 -3.7 5.3 1.5e-07 0.67 0.08 0.62 FALSE
15 GTEx Artery Coronary AF131215.9 0.39 -0.01 lasso 5 -0.01 6.6e-01 1.4 5.2 2.6e-07 0.42 0.07 0.19 TRUE
16 GTEx Artery Tibial ERI1 0.05 0.02 lasso 7 0.01 3.2e-02 5.0 -5.2 1.6e-07 -0.54 0.09 0.83 FALSE
17 GTEx Artery Tibial FAM85A 0.09 0.06 enet 18 0.08 1.5e-06 -5.0 6.0 2.4e-09 0.40 0.03 0.96 TRUE
18 GTEx Brain Cerebellar Hemisphere FAM86B3P 0.28 0.27 lasso 8 0.28 5.4e-08 5.1 -5.3 1.1e-07 -0.55 0.01 0.99 FALSE
19 GTEx Brain Cerebellar Hemisphere AF131215.2 0.15 0.17 lasso 3 0.09 3.0e-03 -5.0 5.4 5.7e-08 0.59 0.21 0.31 FALSE
20 GTEx Brain Cerebellum FAM86B3P 0.19 0.14 lasso 5 0.16 1.8e-05 4.9 -5.4 5.1e-08 -0.57 0.06 0.94 FALSE
21 GTEx Brain Cortex FAM86B3P 0.14 0.05 enet 9 0.07 5.1e-03 4.6 -5.5 3.9e-08 -0.54 0.14 0.38 TRUE
22 GTEx Brain Frontal Cortex BA9 FAM86B3P 0.16 0.13 enet 27 0.10 1.1e-03 5.1 -5.6 1.8e-08 -0.49 0.05 0.87 TRUE
23 GTEx Breast Mammary Tissue AF131215.2 0.16 0.15 lasso 6 0.12 1.1e-06 -5.3 5.4 5.9e-08 0.68 0.57 0.39 FALSE
24 GTEx Breast Mammary Tissue AF131215.9 0.10 0.10 lasso 8 0.12 8.7e-07 -4.3 5.5 3.7e-08 0.71 0.33 0.66 FALSE
25 GTEx Breast Mammary Tissue (Female) AF131215.9 0.04 -0.01 enet 6 0.02 7.3e-02 -5.3 5.8 8.7e-09 0.62 0.08 0.15 FALSE
26 GTEx Cells EBV-transformed lymphocytes AF131215.2 0.20 0.10 enet 14 0.11 1.5e-04 -5.0 5.5 2.9e-08 0.63 0.39 0.54 FALSE
27 GTEx Cells EBV-transformed lymphocytes AF131215.9 0.20 0.15 enet 19 0.13 5.6e-05 -5.0 5.5 3.0e-08 0.59 0.43 0.42 TRUE
28 GTEx Cells Transformed fibroblasts ERI1 0.34 0.35 lasso 7 0.35 1.9e-27 5.2 -5.8 7.3e-09 -0.52 0.28 0.72 FALSE
29 GTEx Cells Transformed fibroblasts FAM86B3P 0.23 0.33 lasso 11 0.38 8.4e-30 5.2 5.4 5.5e-08 0.57 0.28 0.72 FALSE
30 GTEx Colon Sigmoid AF131215.2 0.10 0.00 enet 7 0.02 5.0e-02 5.8 5.3 1.0e-07 0.62 0.14 0.45 FALSE
31 GTEx Colon Sigmoid AF131215.9 0.11 0.17 enet 5 0.09 4.9e-04 -5.1 5.2 1.8e-07 0.59 0.29 0.34 FALSE
32 GTEx Colon Transverse AF131215.9 0.12 0.14 enet 18 0.12 4.0e-06 -5.0 5.4 7.7e-08 0.61 0.20 0.78 FALSE
33 GTEx Esophagus Gastroesophageal Junction MSRA 0.11 -0.01 enet 30 -0.01 8.0e-01 6.2 -5.4 5.5e-08 -0.45 0.10 0.48 FALSE
34 GTEx Esophagus Gastroesophageal Junction AF131215.2 0.13 0.06 enet 10 0.11 6.4e-05 4.5 5.2 2.2e-07 0.63 0.33 0.43 FALSE
35 GTEx Esophagus Mucosa FAM86B3P 0.22 0.17 lasso 8 0.19 1.7e-12 5.2 5.2 2.0e-07 0.55 0.24 0.76 FALSE
36 GTEx Esophagus Mucosa AF131215.2 0.15 0.14 enet 15 0.18 4.3e-12 -4.8 5.4 5.6e-08 0.62 0.92 0.08 FALSE
37 GTEx Esophagus Mucosa AF131215.9 0.18 0.16 lasso 14 0.19 1.6e-12 5.0 5.8 5.2e-09 0.68 0.12 0.88 FALSE
38 GTEx Esophagus Muscularis ERI1 0.12 0.09 enet 13 0.08 7.7e-06 4.3 -5.4 8.4e-08 -0.53 0.26 0.74 FALSE
39 GTEx Esophagus Muscularis FAM85A 0.10 0.01 enet 20 0.04 2.7e-03 -5.2 5.5 2.9e-08 0.41 0.03 0.94 FALSE
40 GTEx Esophagus Muscularis AF131215.9 0.14 0.17 enet 16 0.17 1.6e-10 -5.1 5.8 7.8e-09 0.66 0.58 0.42 FALSE
41 GTEx Heart Atrial Appendage MFHAS1 0.34 0.23 enet 56 0.19 5.7e-09 -5.4 5.9 3.3e-09 0.36 0.08 0.92 TRUE
42 GTEx Heart Left Ventricle AF131215.2 0.05 0.01 enet 11 0.01 1.5e-01 5.5 6.0 2.1e-09 0.64 0.12 0.75 TRUE
43 GTEx Heart Left Ventricle AF131215.9 0.07 0.10 enet 8 0.10 9.4e-06 -5.0 5.6 2.4e-08 0.63 0.24 0.73 FALSE
44 GTEx Lung AF131215.2 0.12 0.08 lasso 5 0.08 1.0e-06 -5.0 5.1 2.6e-07 0.57 0.57 0.43 FALSE
45 GTEx Lung AF131215.9 0.15 0.18 lasso 4 0.15 1.5e-11 -5.0 5.1 2.7e-07 0.56 0.85 0.15 FALSE
46 GTEx Muscle Skeletal FAM85A 0.10 0.01 enet 14 0.06 2.2e-06 -4.0 5.5 3.7e-08 0.28 0.12 0.48 FALSE
47 GTEx Nerve Tibial ERI1 0.07 0.01 enet 16 0.01 4.2e-02 -4.3 -5.6 2.0e-08 -0.51 0.16 0.59 FALSE
48 GTEx Nerve Tibial AF131215.2 0.19 0.18 lasso 12 0.23 3.5e-16 -4.8 5.8 6.9e-09 0.68 0.19 0.81 FALSE
49 GTEx Nerve Tibial AF131215.9 0.17 0.17 lasso 4 0.18 5.0e-13 -5.0 5.2 2.6e-07 0.57 0.76 0.24 FALSE
50 GTEx Pancreas AF131215.2 0.16 0.16 enet 17 0.15 9.1e-07 -5.1 5.8 5.3e-09 0.64 0.19 0.81 FALSE
51 GTEx Pancreas AF131215.9 0.25 0.24 enet 14 0.22 1.0e-09 6.0 6.1 1.4e-09 0.64 0.06 0.94 FALSE
52 GTEx Pituitary FAM86B3P 0.13 0.15 lasso 4 0.13 3.5e-04 -4.7 -5.4 5.4e-08 -0.48 0.04 0.88 FALSE
53 GTEx Prostate AF131215.2 0.18 0.02 lasso 6 0.02 9.6e-02 3.5 5.7 1.6e-08 0.86 0.08 0.50 FALSE
54 GTEx Skin Not Sun Exposed Suprapubic AF131215.2 0.16 0.11 enet 21 0.20 3.9e-11 -4.8 5.2 1.9e-07 0.64 0.43 0.57 FALSE
55 GTEx Skin Not Sun Exposed Suprapubic AF131215.9 0.17 0.14 lasso 8 0.19 9.4e-11 -5.0 5.3 1.2e-07 0.62 0.31 0.69 FALSE
56 GTEx Skin Sun Exposed Lower leg AF131215.2 0.14 0.11 lasso 9 0.16 4.3e-13 -4.8 5.3 1.0e-07 0.62 0.80 0.20 FALSE
57 GTEx Skin Sun Exposed Lower leg FAM85A 0.09 0.04 enet 28 0.04 1.4e-04 -5.1 6.3 2.8e-10 0.35 0.03 0.94 TRUE
58 GTEx Skin Sun Exposed Lower leg AF131215.9 0.19 0.17 enet 29 0.21 3.9e-17 -5.0 5.7 1.5e-08 0.65 0.84 0.16 FALSE
59 GTEx Testis FAM86B3P 0.15 0.14 lasso 7 0.13 2.2e-06 4.6 -5.6 1.7e-08 -0.54 0.02 0.97 FALSE
60 GTEx Testis SGK223 0.29 0.02 enet 19 0.07 3.5e-04 4.7 -5.2 1.9e-07 -0.43 0.09 0.66 TRUE
61 GTEx Testis AF131215.2 0.28 0.18 enet 41 0.17 8.0e-08 -4.8 5.6 1.9e-08 0.62 0.67 0.33 FALSE
62 GTEx Thyroid SGK223 0.19 0.35 enet 16 0.36 1.1e-28 5.0 -5.7 1.6e-08 -0.56 0.39 0.61 TRUE
63 GTEx Thyroid AF131215.2 0.11 0.15 enet 17 0.18 1.2e-13 -4.8 5.7 1.2e-08 0.65 0.84 0.16 FALSE
64 GTEx Thyroid AF131215.9 0.11 0.08 enet 16 0.17 4.7e-13 -5.1 5.1 2.9e-07 0.62 0.46 0.54 FALSE
65 GTEx Uterus AF131215.2 0.17 0.07 enet 13 0.09 7.1e-03 5.7 5.7 1.1e-08 0.71 0.11 0.63 FALSE
66 GTEx Vagina AF131215.9 0.21 0.11 lasso 9 0.08 6.3e-03 5.4 5.5 4.6e-08 0.63 0.16 0.70 FALSE
67 NTR Blood MSRA 0.02 0.01 blup 833 0.01 2.3e-05 4.2 -6.7 2.4e-11 -0.66 0.14 0.86 TRUE
68 NTR Blood PPP1R3B 0.03 0.02 enet 11 0.02 1.5e-07 4.8 5.6 2.0e-08 0.42 0.60 0.39 FALSE
69 ROSMAP Brain Pre-frontal Cortex FAM167A 0.12 0.03 bslmm 620 0.08 1.3e-10 3.4 -5.4 7.2e-08 -0.54 0.09 0.91 FALSE
70 ROSMAP Brain Pre-frontal Cortex XKR6 0.11 0.10 enet 23 0.13 1.2e-16 -4.7 5.9 2.9e-09 0.64 0.50 0.50 TRUE
71 ROSMAP Brain Pre-frontal Cortex FAM85B 0.16 0.23 enet 18 0.22 1.8e-28 5.2 -5.4 5.9e-08 -0.57 0.25 0.75 FALSE
72 ROSMAP Brain Pre-frontal Cortex AF131215.3 0.08 0.10 lasso 7 0.12 8.3e-16 6.0 5.7 1.1e-08 0.68 0.09 0.91 FALSE
73 ROSMAP Brain Pre-frontal Cortex RP11-481A20.11 0.06 0.04 blup 286 0.04 2.2e-06 4.7 6.3 3.7e-10 0.52 0.49 0.50 FALSE
74 ROSMAP Brain Pre-frontal Cortex AF131215.2 0.49 0.57 lasso 7 0.57 9.0e-89 -5.0 5.2 2.1e-07 0.57 0.88 0.12 FALSE
75 The Cancer Genome Atlas Breast Invasive Carcinoma TNKS 0.02 0.00 blup 130 0.01 2.1e-02 4.1 5.1 2.7e-07 0.28 0.04 0.18 TRUE
76 The Cancer Genome Atlas Esophageal Carcinoma FLJ10661 0.20 0.23 lasso 2 0.23 5.6e-08 5.1 5.2 1.6e-07 0.53 0.00 0.99 FALSE
77 The Cancer Genome Atlas Brain Lower Grade Glioma FLJ10661 0.21 0.26 lasso 9 0.30 2.3e-34 5.1 -5.3 9.9e-08 -0.54 0.01 0.99 FALSE
78 The Cancer Genome Atlas Lung Adenocarcinoma ERI1 0.06 0.04 blup 72 0.04 1.5e-05 5.5 -5.1 2.7e-07 -0.46 0.00 1.00 FALSE
79 The Cancer Genome Atlas Thyroid Carcinoma SGK223 0.16 0.20 enet 14 0.22 6.1e-21 -4.6 -5.1 2.7e-07 -0.52 0.03 0.95 FALSE