TWAS hub - TNKS

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0558	0.0261	0.0058	0.026	0.024	0.004	0.026	0.014	0.00022	0.00044	0.081	0.00023	0.0049
2	TCGA	Breast Invasive Carcinoma	0.0206	0.0118	0.0083	0.000	0.006	-0.001	NA	0.000	0.27000	0.02100	0.580	NA	0.4100

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Mother’s age at death	7.9	9.9	12.5	2.7	-3.5
Heel bone mineral density (BMD) T-score, automated (left)	7.6	17.2	31.6	-1.7	5.6
Heel bone mineral density (BMD) T-score, automated (right)	6.8	15.7	31.0	-0.6	5.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	6.3	7.5	7.6	2.8	-2.7
Body mass index (BMI)	6.2	26.3	40.5	-3.5	6.4
Exposure to tobacco smoke at home	5.8	6.5	7.1	-2.4	2.7
Diastolic blood pressure, automated reading	5.5	17.2	23.1	-3.4	4.8
Impedance of leg (right)	5.3	25.5	45.1	2.4	-6.7
Number of full sisters	5.3	6.4	7.4	-2.3	2.7
Worrier / anxious feelings	5.2	9.8	13.9	2.4	-3.7
Impedance of leg (left)	5.1	24.9	45.0	2.2	-6.7
Arm fat mass (right)	5.1	20.9	27.0	-3.8	5.2
Overall health rating	5.1	11.0	19.0	-4.4	1.7
Arm fat mass (left)	5.0	20.7	26.2	-3.9	5.1
Frequency of tenseness / restlessness in last 2 weeks	4.8	7.5	7.8	-2.8	-2.7
Reason for reducing amount of alcohol drunk: Health precaution	4.7	5.4	8.2	1.6	-2.9
Leg fat mass (left)	4.7	18.3	27.3	-3.0	5.2
Leg fat mass (right)	4.6	17.9	26.5	-3.1	5.1
Irritability	4.5	7.7	11.9	1.9	-3.5
Risk taking	4.5	6.6	7.0	-2.5	2.6
Arm fat percentage (right)	4.4	17.3	19.7	-3.8	4.4
Impedance of whole body	4.3	22.1	43.2	0.9	-6.6
Arm fat percentage (left)	4.2	16.8	18.0	-3.9	4.2
Impedance of arm (left)	3.8	17.5	35.0	0.1	-5.9
Impedance of arm (right)	3.7	17.1	34.0	0.5	-5.8
Health satisfaction	3.7	4.8	8.5	-2.9	1.0
Back pain experienced in last month	3.7	5.4	10.3	-3.2	-0.7
Leg fat-free mass (left)	3.6	19.0	30.6	-2.7	5.5
Medication: Ramipril	3.6	4.6	5.3	-2.0	2.3
Weight	3.6	17.8	25.9	-3.1	5.1
Ever had stillbirth, spontaneous miscarriage or termination	3.6	3.8	5.5	-2.3	1.4
Leg predicted mass (left)	3.5	18.6	29.9	-2.7	5.5
Medication: Metformin	3.4	4.8	8.2	-2.9	1.2
Blood clot in the leg (DVT)	3.4	4.4	5.2	-1.9	2.3
Leg predicted mass (right)	3.4	18.3	28.9	-2.8	5.4
Deep venous thrombosis (DVT) (self-reported)	3.4	4.4	4.8	-2.0	2.2
Diabetes (self-reported)	3.3	5.1	9.1	-3.0	1.0
Leg fat-free mass (right)	3.3	17.8	28.4	-2.7	5.3
Leg fat percentage (left)	3.3	11.8	16.5	-2.7	4.1
Type 2 Diabetes (T2D) (2012)	3.2	3.7	7.1	-0.6	2.7
Current tobacco smoking	3.2	5.2	5.3	-2.3	2.2
Fed-up feelings	3.2	5.7	9.7	1.3	-3.1
Whole body fat mass	3.2	13.4	16.1	-3.3	4.0
Smoking status: Current	3.2	5.1	6.6	-1.9	2.6
Supplements: Calcium	3.2	3.5	6.5	0.8	-2.5
Frequency of depressed mood in last 2 weeks	3.1	4.3	8.6	0.1	-2.9
Qualifications: CSEs or equivalent	3.1	4.1	7.8	-2.8	-0.6
Had menopause	3.1	3.8	4.1	1.9	2.0
Financial difficulties in last 2 years	3.1	4.1	5.6	-2.4	1.6
Gout (self-reported)	3.1	4.3	4.3	-2.1	2.1
Bipolar Disorder or Schizophrenia	2.9	7.1	7.3	-2.6	2.7
Systolic blood pressure, automated reading	2.9	8.3	12.3	-2.1	3.5
Serious illness, injury or assault to yourself	2.9	3.6	5.7	-1.2	-2.4
Illnesses of siblings	2.9	4.1	4.2	2.0	-2.1
Hip circumference	2.9	12.5	17.0	-2.8	4.1
Leg fat percentage (right)	2.9	10.5	14.9	-2.5	3.9
Leg pain on walking	2.9	3.6	4.1	-2.0	1.8
Trunk fat mass	2.8	12.0	13.3	-3.3	3.6
Past tobacco smoking	2.8	5.1	8.6	1.3	-2.9
Hypothyroidism/myxoedema (self-reported)	2.8	5.6	6.1	2.2	-2.5
Basal metabolic rate	2.8	15.2	24.4	-2.5	4.9
Pain experienced in last month	2.8	4.7	9.4	3.1	-0.4
Arm predicted mass (left)	2.8	14.4	25.3	-1.9	5.0
Schizophrenia (2018)	2.7	5.6	6.8	-2.1	2.6
Body fat percentage	2.7	10.7	10.8	-3.3	3.3
Miserableness	2.7	4.7	9.3	-0.2	-3.0
Unable to work because of sickness or disability	2.7	3.5	4.9	-2.2	1.5
Neuroticism score	2.6	5.4	10.5	0.5	-3.2
Wheeze or whistling in the chest in last year	2.6	4.7	5.3	-2.0	2.3
Diabetes diagnosed by doctor	2.6	4.3	7.0	-2.6	1.2
Arm fat-free mass (left)	2.6	13.2	24.0	-1.6	4.9
Ever depressed for a whole week	2.6	3.2	6.0	0.6	-2.5
Bipolar Disorder (2011)	2.5	2.4	4.8	-2.2	-0.1
Neuroticism (2016)	2.5	3.6	5.8	-1.2	-2.4
Arm predicted mass (right)	2.5	12.9	22.9	-1.7	4.8
Fractured/broken bones in last 5 years	2.5	3.2	4.9	1.3	-2.2
Alzheimer’s Disease (including proxy)	2.4	3.4	6.7	2.6	-0.4
Fluid intelligence score	2.4	4.9	5.5	2.1	-2.4
Arm fat-free mass (right)	2.4	12.4	22.2	-1.6	4.7
Knee pain experienced in last month	2.4	3.8	6.1	-2.5	1.2
Ever had bowel cancer screening	2.4	2.8	5.3	2.3	-0.5
Breast cancer (self-reported)	2.4	2.8	5.4	2.3	-0.6
Crohns Disease (2012)	2.3	3.7	6.8	-2.6	0.7
Triglycerides	2.3	3.8	4.0	2.0	-1.9
Trunk fat percentage	2.3	9.2	11.2	-3.4	2.7
High blood pressure	2.3	6.3	6.7	-2.4	2.6
Exposure to tobacco smoke outside home	2.3	3.1	4.5	-2.1	1.3
Whole body water mass	2.3	13.0	22.7	-1.8	4.8
Maternal smoking around birth	2.2	3.2	3.3	-1.8	1.7
Pain all over the body in last month	2.2	2.4	4.1	-2.0	0.8
Tense / ‘highly strung’	2.2	3.7	6.1	1.1	-2.5
Family relationship satisfaction	2.2	2.7	4.9	-0.8	-2.2
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	4.4	2.1	1.0
Whole body fat-free mass	2.2	12.6	22.1	-1.8	4.7
Osteoporosis (self-reported)	2.2	2.7	4.2	1.1	-2.1
Rheumatoid Arthritis	2.1	2.8	5.0	2.2	-0.8
Schizophrenia (2014)	2.1	4.7	5.2	-2.1	2.3
Ever used hormone-replacement therapy (HRT)	2.1	2.6	4.2	-2.0	1.0
Vitamin and mineral supplements	2.1	2.9	4.3	2.1	-1.2
Diabetes (mother)	2.0	2.6	3.5	-1.3	1.9
Qualifications: A levels/AS levels or equivalent	2.0	4.4	5.1	2.3	-2.0
Medication: Allopurinol	2.0	2.6	2.9	-1.7	1.5
Hypertension (Self-reported)	2.0	5.7	5.9	-2.3	2.4
Vascular/heart problems diagnosed by doctor	2.0	5.3	5.7	2.4	-2.2
Major Depression (MDD)	1.9	2.3	4.2	-2.1	-0.6
Relative age of first facial hair	1.9	4.0	5.5	-1.6	2.3
Multivitamins +/- minerals	1.9	2.4	3.3	-1.8	1.2
Suffer from ‘nerves’	1.9	2.9	4.1	-1.3	-2.0
Ever had hysterectomy (womb removed)	1.8	2.0	3.9	-0.3	2.0
Frequency of tiredness / lethargy in last 2 weeks	1.8	3.0	5.8	-2.4	-0.3
Comparative body size at age 10	1.8	5.0	9.9	0.2	3.1
Illnesses of father: High blood pressure	1.8	2.2	2.3	-1.5	1.5
Ever smoked	1.8	3.2	5.2	-1.0	2.3
Medication: Levothyroxine sodium	1.7	2.9	4.5	1.2	-2.1
Nervous feelings	1.7	3.2	5.7	0.9	-2.4
Commuting to job workplace: Car/motor vehicle	1.7	2.0	3.9	-0.1	-2.0
Illnesses of siblings: Diabetes	1.7	2.0	3.4	-0.8	1.9
Alzheimer’s Disease (in mother)	1.6	1.9	3.6	1.9	-0.5
Verbal and Numeric Reasoning (VNR)	1.6	3.7	7.2	0.5	-2.7
Heel T-Score	1.6	13.0	25.0	5.0	1.0
Happiness	1.6	1.9	3.9	-0.0	-2.0
Qualifications: O levels/GCSEs or equivalent	1.6	2.6	5.2	2.3	-0.2
Age started oral contraceptive pill	1.6	2.1	3.0	1.7	-1.0
Crohns Disease (2017)	1.5	3.2	5.4	-2.3	1.0
Sitting height	1.5	10.6	13.3	-3.6	2.8
Waist circumference	1.5	5.6	7.1	-2.0	2.7
Number of incorrect matches in round	1.5	2.5	2.5	1.6	-1.6
Trunk fat-free mass	1.5	8.8	15.9	-1.3	4.0
Lung cancer (father)	1.5	1.8	2.7	0.9	-1.6
Trunk predicted mass	1.5	8.8	16.0	-1.2	4.0
Peak expiratory flow (PEF)	1.5	3.6	3.7	1.9	-1.9
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	3.1	-1.8	0.9
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	2.7	1.4	-1.7
Number of children fathered	1.5	1.7	2.8	-1.7	0.7
Osteoarthritis (self-reported)	1.5	1.9	3.1	-1.7	0.9
Supplements: Zinc	1.4	1.6	2.6	-1.6	0.8
Number of live births	1.4	2.1	3.2	-1.8	0.9
Age at first live birth	1.4	2.5	3.2	1.3	-1.8
Qualifications: College or University degree	1.4	4.5	5.2	2.3	-2.0
Wears glasses or contact lenses	1.4	1.6	3.1	1.8	-0.2
Ever had prostate specific antigen (PSA) test	1.4	1.7	3.3	0.2	-1.8
Blood White Count	1.3	10.0	18.7	-4.3	1.1
Stomach or abdominal pain in last month	1.3	1.6	2.8	0.7	-1.7
Qualifications: None of the above	1.3	2.9	5.5	-2.3	0.5
Hair/balding pattern: Pattern 3	1.3	2.0	3.7	0.5	-1.9
Medication for pain relief, constipation, heartburn	1.3	2.2	3.2	1.1	1.8
Migraine (self-reported)	1.3	1.6	3.3	1.8	-0.0
Smoking status: Previous	1.3	1.9	2.7	-1.1	1.6
Medication: Bendroflumethiazide	1.3	1.9	2.8	-1.1	1.7
Intelligence (Savage-Jansen 2018)	1.2	3.5	5.0	1.4	-2.2
Smoking Status	1.2	2.9	3.8	-2.0	1.4
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.1	-1.4	-0.7
Medication for hormone replacement therapy	1.2	1.4	2.8	-1.7	-0.0
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	2.7	-0.4	-1.6
High blood pressure (siblings)	1.2	1.7	2.8	-1.7	0.7
Worry too long after embarrassment	1.2	2.0	3.7	-0.5	-1.9
Shortness of breath walking on level ground	1.2	1.4	2.8	-1.7	0.3
Mood swings	1.2	2.2	4.3	0.3	-2.1
Medication for cholesterol	1.2	1.8	2.8	1.7	-0.9
Financial situation satisfaction	1.2	1.5	3.0	-1.7	0.0
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	2.6	-1.6	-0.7
Bipolar Disorder (2018)	1.1	1.8	2.5	-1.6	1.1
Neuroticism	1.1	2.7	4.2	-2.1	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	2.9	-0.1	-1.7
Asthma	1.1	2.1	3.8	-0.6	1.9
Medication: Blood pressure	1.1	1.9	3.0	-1.7	0.9
Eye problems/disorders: Cataract	1.1	1.3	1.9	0.8	-1.4
Medication: Blood pressure	1.1	2.1	2.5	-1.3	1.6
Basal cell carcinoma (self-reported)	1.1	1.4	1.9	-1.4	0.9
Alzheimer’s Disease (in father)	1.0	1.1	2.0	1.4	0.5
Primary Biliary Cirrhosis	1.0	1.4	2.7	-0.2	1.6
Tanning	1.0	12.7	13.0	3.5	-3.6
Townsend deprivation index at recruitment	1.0	1.4	2.6	-0.6	-1.6
Medication: Atenolol	1.0	1.2	1.6	-0.9	1.3
Hair/balding pattern: Pattern 2	1.0	1.3	1.8	-1.4	0.9
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	1.6	-0.8	-1.3
Depression (self-reported)	1.0	1.2	1.5	-1.2	-1.0
Number of full brothers	1.0	1.3	2.5	-1.6	-0.2
Average weekly red wine intake	1.0	1.5	2.6	-0.5	1.6
Commuting to job workplace: Walk	1.0	1.1	1.3	1.2	1.0
Medication: Aspirin	1.0	1.3	1.7	-0.9	1.3
Depression (Nagel 2018)	0.9	1.3	2.7	0.1	-1.6
High blood pressure (mother)	0.9	1.3	2.1	-1.5	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	5.6	0.4	-2.4
Medication: Paracetamol	0.9	1.5	3.0	-0.2	-1.7
Medication: Aspirin	0.9	1.2	1.3	-1.0	1.1
Mineral and other dietary supplements	0.9	1.2	2.4	1.6	-0.2
Asthma (self-reported)	0.9	1.8	3.0	-0.8	1.7
Medication: Gliclazide	0.9	1.0	1.7	-1.3	0.6
Age at First Birth	0.8	1.1	2.1	1.5	-0.3
Medication: Simvastatin	0.8	1.1	2.2	-1.5	0.1
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	5.1	0.2	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.7	-0.8	-1.3
Pulse wave reflection index	0.8	1.0	1.4	0.8	1.2
Chronic bronchitis/emphysema (mother)	0.8	1.0	1.5	-1.2	0.7
Medication: Omeprazole	0.8	1.0	1.7	-1.3	-0.5
Illnesses of father: Heart disease	0.8	1.1	1.2	1.1	-1.0
Friendships satisfaction	0.8	1.0	2.0	-1.4	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	3.1	0.7	-1.8
Guilty feelings	0.8	1.2	2.4	-0.2	-1.5
Alcohol drinker status: Never	0.8	1.0	1.8	0.5	-1.3
Mean Putamen Volume	0.7	0.8	1.0	1.0	-0.8
LDL Cholesterol	0.7	1.0	1.9	-0.4	-1.4
Lupus	0.7	1.0	1.2	-0.9	1.1
Diabetes (father)	0.7	0.8	1.6	-0.2	1.3
Time employed in main current job	0.7	0.8	1.5	1.2	-0.2
Birth weight of first child	0.7	1.2	1.7	-1.3	0.8
Heart disease (mother)	0.7	0.8	1.6	-0.2	1.3
Chest pain or discomfort	0.7	1.0	1.7	-0.4	-1.3
Age at last live birth	0.7	1.1	2.1	0.1	-1.5
Supplements: Vitamin C	0.7	0.9	1.5	-1.2	0.4
Long-standing illness, disability or infirmity	0.7	1.1	2.0	-1.4	-0.5
Qualifications: nursing, teaching	0.7	1.0	1.9	1.4	-0.4
High cholesterol (Self-reported)	0.7	1.2	1.2	-1.1	-1.1
Body Mass Index (BMI) (2010)	0.6	0.8	1.1	0.7	1.0
Hypothyroidism (self reported)	0.6	1.5	2.9	0.3	1.7
Medication: Co-codamol	0.6	0.7	1.4	-0.2	-1.2
Severe depression (siblings)	0.6	0.7	1.4	1.2	-0.1
Alcohol usually taken with meals	0.6	1.0	1.2	-1.1	0.9
Hearing difficulty/problems with background noise	0.6	0.9	1.8	-1.3	0.3
Mouth/teeth dental problems: Dentures	0.6	1.0	1.8	-0.4	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.7	-1.3	-0.1
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.4	-1.2	-0.2
Alcohol intake frequency.	0.6	1.5	2.1	1.5	0.9
Number of operations (self-reported)	0.6	0.8	1.7	-0.0	1.3
Average weekly beer plus cider intake	0.6	0.8	1.4	-0.5	-1.2
Cholesterol lowering medication	0.6	0.9	1.8	-1.3	0.1
Reaction Time	0.5	1.0	1.4	-1.2	-0.7
Fasting Glucose	0.5	0.5	0.8	-0.9	0.5
Hearing difficulty/problems: Yes	0.5	0.7	1.4	-1.2	0.1
Average weekly fortified wine intake	0.5	0.6	1.1	1.1	0.1
Father’s age at death	0.5	0.6	1.2	1.1	0.0
Pulse rate	0.5	0.9	1.8	-0.1	-1.4
Medication: Lansoprazole	0.5	0.6	0.8	-0.9	0.5
Ever highly irritable/argumentative for 2 days	0.5	0.7	1.3	-1.1	0.0
Medication: Amlodipine	0.5	0.6	1.3	-1.1	0.2
Eye problems/disorders: None of the above	0.5	0.6	1.2	-0.1	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.2	0.1	1.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.4	1.2	-0.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.9	0.5	-0.9
Pain type(s) experienced in last month: Hip pain	0.5	0.6	0.7	-0.7	0.8
Medication: Atorvastatin	0.5	0.6	1.1	-1.1	0.4
Myopia	0.5	0.8	1.4	1.2	-0.3
Heart disease (siblings)	0.5	0.7	1.3	-1.1	0.1
HbA1C	0.4	0.4	0.4	0.6	0.7
Ulcerative Colitis	0.4	0.5	0.6	0.7	-0.8
Blood Red Count	0.4	3.9	7.4	-0.6	2.7
BMI	0.4	2.3	2.3	-1.5	1.5
Systolic Blood Pressure	0.4	1.8	3.4	-1.8	-0.4
Cardiovascular Disease	0.4	1.2	2.3	-1.5	-0.1
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.5	-1.2	0.1
Lung FVC	0.4	2.0	3.4	-1.8	-0.8
Hand grip strength (left)	0.4	1.1	1.9	1.4	0.6
Sensitivity / hurt feelings	0.4	0.7	0.9	0.7	-1.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.7	0.4	-0.8
Forced vital capacity (FVC)	0.4	1.7	3.4	-0.3	-1.8
Allergy	0.4	0.9	1.4	0.7	-1.2
Alcohol intake versus 10 years previously	0.4	0.5	1.0	0.1	1.0
Noisy workplace	0.4	0.5	0.9	0.2	1.0
Medication: Cholesterol lowering	0.4	0.7	0.7	-0.9	0.8
Prospective memory result	0.4	0.6	1.0	1.0	-0.2
Illnesses of mother	0.4	0.5	0.5	-0.7	-0.7
Neck or shoulder pain in last month	0.4	0.5	0.8	0.6	-0.9
Mean time to correctly identify matches	0.4	0.8	1.2	-1.1	-0.7
Illnesses of father: None of the above (group 1)	0.4	0.5	1.0	-0.0	-1.0
Average weekly champagne plus white wine intake	0.4	0.6	1.1	0.1	1.1
Ever taken oral contraceptive pill	0.4	0.4	0.5	-0.6	-0.7
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.0	-1.0	0.4
Irritable Bowel Disease (IBD)	0.3	0.6	1.1	-1.1	0.4
Ovarian Cancer	0.3	0.4	0.7	0.8	-0.5
Number of treatments/medications taken	0.3	0.5	0.9	-0.9	-0.4
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.7	0.0	-0.8
Hand grip strength (right)	0.3	0.8	1.3	1.2	0.5
Age when periods started (menarche)	0.3	0.8	1.5	-1.2	0.1
Had other major operations	0.3	0.3	0.6	0.2	0.8
Mouth/teeth dental problems	0.3	0.4	0.5	0.7	-0.6
Falls in the last year	0.3	0.4	0.8	-0.2	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.4	-0.5	-0.7
Headache pain in last month	0.3	0.5	0.7	-0.5	-0.8
Glaucoma (self-reported)	0.3	0.3	0.4	0.5	-0.6
Birth weight	0.3	0.6	1.1	0.4	1.0
Forced vital capacity (FVC), Best measure	0.3	1.2	2.3	-0.4	-1.5
Medication: Ibuprofen	0.3	0.3	0.4	-0.5	-0.6
Medication: Seretide 50 evohaler	0.3	0.3	0.4	-0.5	0.7
Pulse rate, automated reading	0.3	0.8	1.7	-1.3	0.2
Eye problems/disorders: Glaucoma	0.3	0.3	0.6	-0.8	-0.1
Medication: Paracetamol	0.3	0.4	0.7	-0.4	-0.9
Commuting to job workplace: Cycle	0.3	0.3	0.7	0.8	-0.0
Depressed Affect (Nagel 2018)	0.2	0.3	0.7	-0.1	-0.8
Schizophrenia vs Biploar Disorder	0.2	0.3	0.4	-0.7	0.3
Breast Cancer	0.2	0.6	1.1	-0.2	-1.0
Lung FEV1/FVC ratio	0.2	1.1	1.4	1.2	0.8
Hair Pigment	0.2	4.5	8.6	-2.9	0.6
Average weekly spirits intake	0.2	0.3	0.4	0.6	-0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.4	-0.6	-0.5
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.4	-0.6	0.6
Supplements: Glucosamine	0.2	0.2	0.2	-0.5	0.4
Chronic bronchitis/emphysema (father)	0.2	0.3	0.4	-0.4	-0.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.4	-0.4	-0.6
Standing height	0.2	2.3	4.6	0.3	-2.1
Length of working week for main job	0.2	0.2	0.4	-0.6	-0.0
Breastfed as a baby	0.2	0.2	0.4	0.6	-0.1
Hair/balding pattern: Pattern 4	0.2	0.5	1.0	-0.1	-1.0
Loud music exposure frequency	0.2	0.3	0.5	0.1	0.7
Angina (self-reported)	0.2	0.3	0.3	-0.5	0.5
Comparative height size at age 10	0.2	1.3	1.7	1.3	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	0.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.9	-0.9	-0.3
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	0.1	0.7
Neuroticism (Nagel 2018)	0.1	0.3	0.7	-0.1	-0.8
Ulcerative Colitis (UC)	0.1	0.1	0.2	0.5	-0.1
HDL Cholesterol	0.1	0.2	0.2	-0.5	0.4
Blood Eosinophil Count	0.1	1.1	2.2	-0.1	1.5
Blood Platelet Count	0.1	1.6	2.2	-1.5	-1.0
Allergy or Eczema	0.1	0.1	0.2	0.3	-0.4
Pack years adult smoking proportion	0.1	0.1	0.2	-0.4	0.2
Relative age voice broke	0.1	0.1	0.2	0.4	0.0
Taking other prescription medications	0.1	0.1	0.2	0.4	-0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.4	-0.1
Heart attack	0.1	0.1	0.1	-0.4	0.1
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.1	0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.4	-0.1
Pulse wave peak to peak time	0.1	0.1	0.2	0.1	-0.5
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.4	-0.3
Had major operations	0.1	0.1	0.2	-0.5	-0.2
Loneliness, isolation	0.1	0.1	0.2	-0.5	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	-0.1	-0.5
Medication: Lisinopril	0.1	0.1	0.1	-0.3	-0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.4	0.2
Worry (Nagel 2018)	0.0	0.1	0.2	-0.4	-0.1
Prostate Cancer	0.0	0.0	0.1	0.1	-0.3
Coronary Artery Disease (CAD)	0.0	0.0	0.0	-0.2	0.1
Height	0.0	0.9	1.7	0.4	1.3
Waist Hip Ratio (WHR)	0.0	0.1	0.1	-0.3	-0.3
Respiratory disease	0.0	0.1	0.2	0.4	-0.2
Chronotype (morning person)	0.0	0.0	0.1	0.0	-0.3
Angina	0.0	0.1	0.1	-0.2	0.3
Number of self-reported non-cancer illnesses	0.0	0.0	0.0	0.1	-0.1
Hearing aid user	0.0	0.1	0.1	-0.0	0.3
Commuting to job workplace: Public transport	0.0	0.0	0.0	0.0	-0.0
Alcohol drinker status: Previous	0.0	0.0	0.0	0.1	0.2
Pack years of smoking	0.0	0.0	0.0	0.0	0.1

Hub : Genes

TNKS

Models

Trait associations