Hub : Genes

TNKS

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 ROSMAP Brain Pre-frontal Cortex 0.0558 0.0261 0.0058 0.026 0.024 0.004 0.026 0.014 0.00022 0.00044 0.081 0.00023 0.0049
2 TCGA Breast Invasive Carcinoma 0.0206 0.0118 0.0083 0.000 0.006 -0.001 NA 0.000 0.27000 0.02100 0.580 NA 0.4100

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.1 1.8 2.5 -1.6 1.1
Bipolar Disorder or Schizophrenia 2.9 7.1 7.3 -2.6 2.7
Depressed Affect (Nagel 2018) 0.2 0.3 0.7 -0.1 -0.8
Depression (Nagel 2018) 0.9 1.3 2.7 0.1 -1.6
Intelligence (Savage-Jansen 2018) 1.2 3.5 5.0 1.4 -2.2
Neuroticism (Nagel 2018) 0.1 0.3 0.7 -0.1 -0.8
Schizophrenia (2018) 2.7 5.6 6.8 -2.1 2.6
Schizophrenia vs Biploar Disorder 0.2 0.3 0.4 -0.7 0.3
Worry (Nagel 2018) 0.0 0.1 0.2 -0.4 -0.1
Alzheimer’s Disease (in mother) 1.6 1.9 3.6 1.9 -0.5
Alzheimer’s Disease (in father) 1.0 1.1 2.0 1.4 0.5
Alzheimer’s Disease (including proxy) 2.4 3.4 6.7 2.6 -0.4
Crohns Disease (2017) 1.5 3.2 5.4 -2.3 1.0
Irritable Bowel Disease (IBD) 0.3 0.6 1.1 -1.1 0.4
Ulcerative Colitis (UC) 0.1 0.1 0.2 0.5 -0.1
Major Depression (MDD) 1.9 2.3 4.2 -2.1 -0.6
Reaction Time 0.5 1.0 1.4 -1.2 -0.7
Verbal and Numeric Reasoning (VNR) 1.6 3.7 7.2 0.5 -2.7
Breast Cancer 0.2 0.6 1.1 -0.2 -1.0
Ovarian Cancer 0.3 0.4 0.7 0.8 -0.5
Prostate Cancer 0.0 0.0 0.1 0.1 -0.3
Age at First Birth 0.8 1.1 2.1 1.5 -0.3
Bipolar Disorder (2011) 2.5 2.4 4.8 -2.2 -0.1
Body Mass Index (BMI) (2010) 0.6 0.8 1.1 0.7 1.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 -0.2 0.1
Crohns Disease (2012) 2.3 3.7 6.8 -2.6 0.7
Mean Putamen Volume 0.7 0.8 1.0 1.0 -0.8
Fasting Glucose 0.5 0.5 0.8 -0.9 0.5
HbA1C 0.4 0.4 0.4 0.6 0.7
HDL Cholesterol 0.1 0.2 0.2 -0.5 0.4
LDL Cholesterol 0.7 1.0 1.9 -0.4 -1.4
Lupus 0.7 1.0 1.2 -0.9 1.1
Neuroticism (2016) 2.5 3.6 5.8 -1.2 -2.4
Primary Biliary Cirrhosis 1.0 1.4 2.7 -0.2 1.6
Rheumatoid Arthritis 2.1 2.8 5.0 2.2 -0.8
Schizophrenia (2014) 2.1 4.7 5.2 -2.1 2.3
Triglycerides 2.3 3.8 4.0 2.0 -1.9
Type 2 Diabetes (T2D) (2012) 3.2 3.7 7.1 -0.6 2.7
Ulcerative Colitis 0.4 0.5 0.6 0.7 -0.8
Blood Eosinophil Count 0.1 1.1 2.2 -0.1 1.5
Blood Platelet Count 0.1 1.6 2.2 -1.5 -1.0
Blood Red Count 0.4 3.9 7.4 -0.6 2.7
Blood White Count 1.3 10.0 18.7 -4.3 1.1
Heel T-Score 1.6 13.0 25.0 5.0 1.0
BMI 0.4 2.3 2.3 -1.5 1.5
Height 0.0 0.9 1.7 0.4 1.3
Waist Hip Ratio (WHR) 0.0 0.1 0.1 -0.3 -0.3
Systolic Blood Pressure 0.4 1.8 3.4 -1.8 -0.4
Smoking Status 1.2 2.9 3.8 -2.0 1.4
Allergy or Eczema 0.1 0.1 0.2 0.3 -0.4
Cardiovascular Disease 0.4 1.2 2.3 -1.5 -0.1
Hypothyroidism (self reported) 0.6 1.5 2.9 0.3 1.7
Respiratory disease 0.0 0.1 0.2 0.4 -0.2
Type 2 Diabetes (T2D) (2018) 0.4 0.8 1.5 -1.2 0.1
Lung FEV1/FVC ratio 0.2 1.1 1.4 1.2 0.8
Lung FVC 0.4 2.0 3.4 -1.8 -0.8
Neuroticism 1.1 2.7 4.2 -2.1 1.1
Chronotype (morning person) 0.0 0.0 0.1 0.0 -0.3
Hair Pigment 0.2 4.5 8.6 -2.9 0.6
Tanning 1.0 12.7 13.0 3.5 -3.6
Hand grip strength (left) 0.4 1.1 1.9 1.4 0.6
Number of treatments/medications taken 0.3 0.5 0.9 -0.9 -0.4
Average weekly spirits intake 0.2 0.3 0.4 0.6 -0.4
Sensitivity / hurt feelings 0.4 0.7 0.9 0.7 -1.0
Frequency of depressed mood in last 2 weeks 3.1 4.3 8.6 0.1 -2.9
Hearing difficulty/problems: Yes 0.5 0.7 1.4 -1.2 0.1
Relative age of first facial hair 1.9 4.0 5.5 -1.6 2.3
Other serious medical condition/disability diagnosed by doctor 0.3 0.3 0.7 0.0 -0.8
Ever used hormone-replacement therapy (HRT) 2.1 2.6 4.2 -2.0 1.0
Ever had hysterectomy (womb removed) 1.8 2.0 3.9 -0.3 2.0
Systolic blood pressure, automated reading 2.9 8.3 12.3 -2.1 3.5
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 2.1 -1.4 -0.7
Angina 0.0 0.1 0.1 -0.2 0.3
Medication for hormone replacement therapy 1.2 1.4 2.8 -1.7 -0.0
Vitamin and mineral supplements 2.1 2.9 4.3 2.1 -1.2
Supplements: Zinc 1.4 1.6 2.6 -1.6 0.8
Medication: Co-codamol 0.6 0.7 1.4 -0.2 -1.2
Medication: Metformin 3.4 4.8 8.2 -2.9 1.2
Diabetes (father) 0.7 0.8 1.6 -0.2 1.3
Diabetes (mother) 2.0 2.6 3.5 -1.3 1.9
Severe depression (siblings) 0.6 0.7 1.4 1.2 -0.1
Pack years adult smoking proportion 0.1 0.1 0.2 -0.4 0.2
Impedance of leg (right) 5.3 25.5 45.1 2.4 -6.7
Leg fat-free mass (left) 3.6 19.0 30.6 -2.7 5.5
Trunk fat percentage 2.3 9.2 11.2 -3.4 2.7
Hand grip strength (right) 0.3 0.8 1.3 1.2 0.5
Townsend deprivation index at recruitment 1.0 1.4 2.6 -0.6 -1.6
Current tobacco smoking 3.2 5.2 5.3 -2.3 2.2
Average weekly fortified wine intake 0.5 0.6 1.1 1.1 0.1
Maternal smoking around birth 2.2 3.2 3.3 -1.8 1.7
Fed-up feelings 3.2 5.7 9.7 1.3 -3.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 2.9 -0.1 -1.7
Relative age voice broke 0.1 0.1 0.2 0.4 0.0
Taking other prescription medications 0.1 0.1 0.2 0.4 -0.2
Age when periods started (menarche) 0.3 0.8 1.5 -1.2 0.1
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.4 -0.6 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 7.6 17.2 31.6 -1.7 5.6
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.1 0.4 -0.1
Qualifications: CSEs or equivalent 3.1 4.1 7.8 -2.8 -0.6
Serious illness, injury or assault to yourself 2.9 3.6 5.7 -1.2 -2.4
High blood pressure 2.3 6.3 6.7 -2.4 2.6
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.4 -0.6 0.6
Multivitamins +/- minerals 1.9 2.4 3.3 -1.8 1.2
Stomach or abdominal pain in last month 1.3 1.6 2.8 0.7 -1.7
Supplements: Glucosamine 0.2 0.2 0.2 -0.5 0.4
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 0.7 0.4 -0.8
Medication: Atenolol 1.0 1.2 1.6 -0.9 1.3
Medication: Levothyroxine sodium 1.7 2.9 4.5 1.2 -2.1
Sitting height 1.5 10.6 13.3 -3.6 2.8
Chronic bronchitis/emphysema (father) 0.2 0.3 0.4 -0.4 -0.7
High blood pressure (mother) 0.9 1.3 2.1 -1.5 0.6
Body mass index (BMI) 6.2 26.3 40.5 -3.5 6.4
Impedance of leg (left) 5.1 24.9 45.0 2.2 -6.7
Leg predicted mass (left) 3.5 18.6 29.9 -2.7 5.5
Trunk fat mass 2.8 12.0 13.3 -3.3 3.6
Waist circumference 1.5 5.6 7.1 -2.0 2.7
Number of incorrect matches in round 1.5 2.5 2.5 1.6 -1.6
Past tobacco smoking 2.8 5.1 8.6 1.3 -2.9
Alcohol usually taken with meals 0.6 1.0 1.2 -1.1 0.9
Nervous feelings 1.7 3.2 5.7 0.9 -2.4
Frequency of tenseness / restlessness in last 2 weeks 4.8 7.5 7.8 -2.8 -2.7
Hearing difficulty/problems with background noise 0.6 0.9 1.8 -1.3 0.3
Hair/balding pattern: Pattern 2 1.0 1.3 1.8 -1.4 0.9
Had menopause 3.1 3.8 4.1 1.9 2.0
Had other major operations 0.3 0.3 0.6 0.2 0.8
Forced vital capacity (FVC) 0.4 1.7 3.4 -0.3 -1.8
Heel bone mineral density (BMD) T-score, automated (right) 6.8 15.7 31.0 -0.6 5.6
Ever unenthusiastic/disinterested for a whole week 1.2 1.4 2.7 -0.4 -1.6
Qualifications: None of the above 1.3 2.9 5.5 -2.3 0.5
Financial difficulties in last 2 years 3.1 4.1 5.6 -2.4 1.6
Mouth/teeth dental problems 0.3 0.4 0.5 0.7 -0.6
Heart attack 0.1 0.1 0.1 -0.4 0.1
Allergy 0.4 0.9 1.4 0.7 -1.2
Pain all over the body in last month 2.2 2.4 4.1 -2.0 0.8
Diabetes (self-reported) 3.3 5.1 9.1 -3.0 1.0
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.4 -0.4 -0.6
Medication: Ramipril 3.6 4.6 5.3 -2.0 2.3
Medication: Simvastatin 0.8 1.1 2.2 -1.5 0.1
Fluid intelligence score 2.4 4.9 5.5 2.1 -2.4
Illnesses of siblings 2.9 4.1 4.2 2.0 -2.1
Neuroticism score 2.6 5.4 10.5 0.5 -3.2
Weight 3.6 17.8 25.9 -3.1 5.1
Impedance of arm (right) 3.7 17.1 34.0 0.5 -5.8
Arm fat percentage (right) 4.4 17.3 19.7 -3.8 4.4
Trunk fat-free mass 1.5 8.8 15.9 -1.3 4.0
Hip circumference 2.9 12.5 17.0 -2.8 4.1
Time employed in main current job 0.7 0.8 1.5 1.2 -0.2
Alcohol intake versus 10 years previously 0.4 0.5 1.0 0.1 1.0
Father’s age at death 0.5 0.6 1.2 1.1 0.0
Worrier / anxious feelings 5.2 9.8 13.9 2.4 -3.7
Frequency of tiredness / lethargy in last 2 weeks 1.8 3.0 5.8 -2.4 -0.3
Falls in the last year 0.3 0.4 0.8 -0.2 -0.9
Hair/balding pattern: Pattern 3 1.3 2.0 3.7 0.5 -1.9
Number of live births 1.4 2.1 3.2 -1.8 0.9
Forced expiratory volume in 1-second (FEV1) 0.8 2.6 5.1 0.2 -2.3
Pulse rate 0.5 0.9 1.8 -0.1 -1.4
Happiness 1.6 1.9 3.9 -0.0 -2.0
Noisy workplace 0.4 0.5 0.9 0.2 1.0
Qualifications: A levels/AS levels or equivalent 2.0 4.4 5.1 2.3 -2.0
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 1.6 -0.8 -1.3
Mouth/teeth dental problems: Dentures 0.6 1.0 1.8 -0.4 1.3
Asthma 1.1 2.1 3.8 -0.6 1.9
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 0.4 -0.5 -0.7
Medication: Cholesterol lowering 0.4 0.7 0.7 -0.9 0.8
Depression (self-reported) 1.0 1.2 1.5 -1.2 -1.0
Medication: Lansoprazole 0.5 0.6 0.8 -0.9 0.5
Prospective memory result 0.4 0.6 1.0 1.0 -0.2
Lung cancer (father) 1.5 1.8 2.7 0.9 -1.6
Illnesses of mother 0.4 0.5 0.5 -0.7 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.9 5.6 0.4 -2.4
Pulse wave Arterial Stiffness index 0.1 0.1 0.2 -0.1 0.4
Impedance of arm (left) 3.8 17.5 35.0 0.1 -5.9
Arm fat mass (right) 5.1 20.9 27.0 -3.8 5.2
Trunk predicted mass 1.5 8.8 16.0 -1.2 4.0
Standing height 0.2 2.3 4.6 0.3 -2.1
Length of working week for main job 0.2 0.2 0.4 -0.6 -0.0
Exposure to tobacco smoke at home 5.8 6.5 7.1 -2.4 2.7
Breastfed as a baby 0.2 0.2 0.4 0.6 -0.1
Tense / ‘highly strung’ 2.2 3.7 6.1 1.1 -2.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 1.7 -0.8 -1.3
Hair/balding pattern: Pattern 4 0.2 0.5 1.0 -0.1 -1.0
Birth weight of first child 0.7 1.2 1.7 -1.3 0.8
Peak expiratory flow (PEF) 1.5 3.6 3.7 1.9 -1.9
Pulse wave reflection index 0.8 1.0 1.4 0.8 1.2
Ever highly irritable/argumentative for 2 days 0.5 0.7 1.3 -1.1 0.0
Loud music exposure frequency 0.2 0.3 0.5 0.1 0.7
Qualifications: O levels/GCSEs or equivalent 1.6 2.6 5.2 2.3 -0.2
Mouth/teeth dental problems: Bleeding gums 1.5 1.9 3.1 -1.8 0.9
Blood clot in the leg (DVT) 3.4 4.4 5.2 -1.9 2.3
Medication: Paracetamol 0.9 1.5 3.0 -0.2 -1.7
Headache pain in last month 0.3 0.5 0.7 -0.5 -0.8
Medication for cholesterol, blood pressure or diabetes 1.5 2.4 2.7 1.4 -1.7
Glaucoma (self-reported) 0.3 0.3 0.4 0.5 -0.6
Gout (self-reported) 3.1 4.3 4.3 -2.1 2.1
Hypothyroidism/myxoedema (self-reported) 2.8 5.6 6.1 2.2 -2.5
Medication: Amlodipine 0.5 0.6 1.3 -1.1 0.2
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 -0.4 -0.1
Birth weight 0.3 0.6 1.1 0.4 1.0
Chronic bronchitis/emphysema (mother) 0.8 1.0 1.5 -1.2 0.7
High blood pressure (siblings) 1.2 1.7 2.8 -1.7 0.7
Forced vital capacity (FVC), Best measure 0.3 1.2 2.3 -0.4 -1.5
Body fat percentage 2.7 10.7 10.8 -3.3 3.3
Leg fat percentage (right) 2.9 10.5 14.9 -2.5 3.9
Arm fat-free mass (right) 2.4 12.4 22.2 -1.6 4.7
Exposure to tobacco smoke outside home 2.3 3.1 4.5 -2.1 1.3
Comparative body size at age 10 1.8 5.0 9.9 0.2 3.1
Number of full brothers 1.0 1.3 2.5 -1.6 -0.2
Worry too long after embarrassment 1.2 2.0 3.7 -0.5 -1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.7 -1.3 -0.1
Wheeze or whistling in the chest in last year 2.6 4.7 5.3 -2.0 2.3
Number of children fathered 1.5 1.7 2.8 -1.7 0.7
Reason for reducing amount of alcohol drunk: Health precaution 4.7 5.4 8.2 1.6 -2.9
Age at first live birth 1.4 2.5 3.2 1.3 -1.8
Pulse wave peak to peak time 0.1 0.1 0.2 0.1 -0.5
Health satisfaction 3.7 4.8 8.5 -2.9 1.0
Shortness of breath walking on level ground 1.2 1.4 2.8 -1.7 0.3
Qualifications: College or University degree 1.4 4.5 5.2 2.3 -2.0
Eye problems/disorders: None of the above 0.5 0.6 1.2 -0.1 1.1
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.4 -1.2 -0.2
Emphysema/chronic bronchitis 0.1 0.1 0.2 0.4 -0.3
Medication for pain relief, constipation, heartburn 1.3 2.2 3.2 1.1 1.8
Neck or shoulder pain in last month 0.4 0.5 0.8 0.6 -0.9
Medication: Blood pressure 1.1 1.9 3.0 -1.7 0.9
Angina (self-reported) 0.2 0.3 0.3 -0.5 0.5
Migraine (self-reported) 1.3 1.6 3.3 1.8 -0.0
Medication: Ibuprofen 0.3 0.3 0.4 -0.5 -0.6
Medication: Allopurinol 2.0 2.6 2.9 -1.7 1.5
Medication: Omeprazole 0.8 1.0 1.7 -1.3 -0.5
Medication: Seretide 50 evohaler 0.3 0.3 0.4 -0.5 0.7
Mean time to correctly identify matches 0.4 0.8 1.2 -1.1 -0.7
Heart disease (mother) 0.7 0.8 1.6 -0.2 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 6.3 7.5 7.6 2.8 -2.7
Whole body fat mass 3.2 13.4 16.1 -3.3 4.0
Leg fat mass (right) 4.6 17.9 26.5 -3.1 5.1
Arm predicted mass (right) 2.5 12.9 22.9 -1.7 4.8
Pulse rate, automated reading 0.3 0.8 1.7 -1.3 0.2
Alcohol intake frequency. 0.6 1.5 2.1 1.5 0.9
Comparative height size at age 10 0.2 1.3 1.7 1.3 -0.9
Number of full sisters 5.3 6.4 7.4 -2.3 2.7
Suffer from ‘nerves’ 1.9 2.9 4.1 -1.3 -2.0
Overall health rating 5.1 11.0 19.0 -4.4 1.7
Chest pain or discomfort 0.7 1.0 1.7 -0.4 -1.3
Had major operations 0.1 0.1 0.2 -0.5 -0.2
Age at last live birth 0.7 1.1 2.1 0.1 -1.5
Family relationship satisfaction 2.2 2.7 4.9 -0.8 -2.2
Leg pain on walking 2.9 3.6 4.1 -2.0 1.8
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.2 0.1 1.1
Commuting to job workplace: Car/motor vehicle 1.7 2.0 3.9 -0.1 -2.0
Illness, injury, bereavement, stress in last 2 years 2.2 2.7 4.4 2.1 1.0
Medication: Aspirin 0.9 1.2 1.3 -1.0 1.1
Supplements: Vitamin C 0.7 0.9 1.5 -1.2 0.4
Knee pain experienced in last month 2.4 3.8 6.1 -2.5 1.2
Hypertension (Self-reported) 2.0 5.7 5.9 -2.3 2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.4 0.1 0.6
Illnesses of father: Heart disease 0.8 1.1 1.2 1.1 -1.0
Illnesses of siblings: Diabetes 1.7 2.0 3.4 -0.8 1.9
Smoking status: Previous 1.3 1.9 2.7 -1.1 1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 0.9 -0.9 -0.3
Whole body fat-free mass 2.2 12.6 22.1 -1.8 4.7
Leg fat-free mass (right) 3.3 17.8 28.4 -2.7 5.3
Arm fat percentage (left) 4.2 16.8 18.0 -3.9 4.2
Average weekly red wine intake 1.0 1.5 2.6 -0.5 1.6
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.5 0.1 0.7
Mood swings 1.2 2.2 4.3 0.3 -2.1
Loneliness, isolation 0.1 0.1 0.2 -0.5 0.1
Long-standing illness, disability or infirmity 0.7 1.1 2.0 -1.4 -0.5
Ever had bowel cancer screening 2.4 2.8 5.3 2.3 -0.5
Diabetes diagnosed by doctor 2.6 4.3 7.0 -2.6 1.2
Ever had stillbirth, spontaneous miscarriage or termination 3.6 3.8 5.5 -2.3 1.4
Friendships satisfaction 0.8 1.0 2.0 -1.4 0.0
Qualifications: nursing, teaching 0.7 1.0 1.9 1.4 -0.4
Commuting to job workplace: Walk 1.0 1.1 1.3 1.2 1.0
Eye problems/disorders: Cataract 1.1 1.3 1.9 0.8 -1.4
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.4 1.2 -0.5
Medication for cholesterol 1.2 1.8 2.8 1.7 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.3 -0.1 -0.5
Back pain experienced in last month 3.7 5.4 10.3 -3.2 -0.7
Mineral and other dietary supplements 0.9 1.2 2.4 1.6 -0.2
Breast cancer (self-reported) 2.4 2.8 5.4 2.3 -0.6
Asthma (self-reported) 0.9 1.8 3.0 -0.8 1.7
Osteoporosis (self-reported) 2.2 2.7 4.2 1.1 -2.1
Osteoarthritis (self-reported) 1.5 1.9 3.1 -1.7 0.9
Medication: Aspirin 1.0 1.3 1.7 -0.9 1.3
Medication: Gliclazide 0.9 1.0 1.7 -1.3 0.6
Illnesses of father: None of the above (group 1) 0.4 0.5 1.0 -0.0 -1.0
Smoking status: Current 3.2 5.1 6.6 -1.9 2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.8 3.1 0.7 -1.8
Whole body water mass 2.3 13.0 22.7 -1.8 4.8
Leg predicted mass (right) 3.4 18.3 28.9 -2.8 5.4
Arm fat mass (left) 5.0 20.7 26.2 -3.9 5.1
Number of self-reported non-cancer illnesses 0.0 0.0 0.0 0.1 -0.1
Average weekly champagne plus white wine intake 0.4 0.6 1.1 0.1 1.1
Miserableness 2.7 4.7 9.3 -0.2 -3.0
Guilty feelings 0.8 1.2 2.4 -0.2 -1.5
Wears glasses or contact lenses 1.4 1.6 3.1 1.8 -0.2
Ever taken oral contraceptive pill 0.4 0.4 0.5 -0.6 -0.7
Hearing aid user 0.0 0.1 0.1 -0.0 0.3
Mother’s age at death 7.9 9.9 12.5 2.7 -3.5
Financial situation satisfaction 1.2 1.5 3.0 -1.7 0.0
Tinnitus: Yes, now most or all of the time 0.5 0.6 0.9 0.5 -0.9
Commuting to job workplace: Public transport 0.0 0.0 0.0 0.0 -0.0
Eye problems/disorders: Glaucoma 0.3 0.3 0.6 -0.8 -0.1
Medication: Blood pressure 1.1 2.1 2.5 -1.3 1.6
Pain type(s) experienced in last month: Hip pain 0.5 0.6 0.7 -0.7 0.8
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.0 -1.0 0.4
High cholesterol (Self-reported) 0.7 1.2 1.2 -1.1 -1.1
Medication: Bendroflumethiazide 1.3 1.9 2.8 -1.1 1.7
Medication: Paracetamol 0.3 0.4 0.7 -0.4 -0.9
Medication: Lisinopril 0.1 0.1 0.1 -0.3 -0.3
Medication: Atorvastatin 0.5 0.6 1.1 -1.1 0.4
Illnesses of father: High blood pressure 1.8 2.2 2.3 -1.5 1.5
Alcohol drinker status: Never 0.8 1.0 1.8 0.5 -1.3
Ever smoked 1.8 3.2 5.2 -1.0 2.3
Basal metabolic rate 2.8 15.2 24.4 -2.5 4.9
Leg fat percentage (left) 3.3 11.8 16.5 -2.7 4.1
Arm fat-free mass (left) 2.6 13.2 24.0 -1.6 4.9
Number of operations (self-reported) 0.6 0.8 1.7 -0.0 1.3
Average weekly beer plus cider intake 0.6 0.8 1.4 -0.5 -1.2
Irritability 4.5 7.7 11.9 1.9 -3.5
Risk taking 4.5 6.6 7.0 -2.5 2.6
Ever had prostate specific antigen (PSA) test 1.4 1.7 3.3 0.2 -1.8
Fractured/broken bones in last 5 years 2.5 3.2 4.9 1.3 -2.2
Age started oral contraceptive pill 1.6 2.1 3.0 1.7 -1.0
Diastolic blood pressure, automated reading 5.5 17.2 23.1 -3.4 4.8
Ever depressed for a whole week 2.6 3.2 6.0 0.6 -2.5
Unable to work because of sickness or disability 2.7 3.5 4.9 -2.2 1.5
Commuting to job workplace: Cycle 0.3 0.3 0.7 0.8 -0.0
Myopia 0.5 0.8 1.4 1.2 -0.3
Vascular/heart problems diagnosed by doctor 2.0 5.3 5.7 2.4 -2.2
Cholesterol lowering medication 0.6 0.9 1.8 -1.3 0.1
Medication: Omeprazole (e.g. Zanprol) 1.2 1.5 2.6 -1.6 -0.7
Pain experienced in last month 2.8 4.7 9.4 3.1 -0.4
Supplements: Calcium 3.2 3.5 6.5 0.8 -2.5
Basal cell carcinoma (self-reported) 1.1 1.4 1.9 -1.4 0.9
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.2 -0.4 0.2
Deep venous thrombosis (DVT) (self-reported) 3.4 4.4 4.8 -2.0 2.2
Heart disease (siblings) 0.5 0.7 1.3 -1.1 0.1
Alcohol drinker status: Previous 0.0 0.0 0.0 0.1 0.2
Pack years of smoking 0.0 0.0 0.0 0.0 0.1
Impedance of whole body 4.3 22.1 43.2 0.9 -6.6
Leg fat mass (left) 4.7 18.3 27.3 -3.0 5.2
Arm predicted mass (left) 2.8 14.4 25.3 -1.9 5.0