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chr7:149,577,591-151,668,435

Best TWAS P=2.68e-22 · Best GWAS P=2.33e-33 conditioned to 0.00557

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Brain Cerebellum	KCNH2	0.35	0.20	enet	24	0.28	4.8e-09	-11.4	-9.7	2.7e-22	0.83	0.00	1.00	TRUE
21	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TMEM176A	0.15	0.00	lasso	10	0.02	5.7e-02	8.7	7.3	3.1e-13	-0.24	0.01	0.31	TRUE
2	GTEx	Artery Coronary	RP11-148K1.12	0.31	-0.01	enet	16	0.00	2.2e-01	5.5	-6.7	2.0e-11	0.17	0.08	0.06	TRUE
5	GTEx	Colon Transverse	ABCB8	0.17	0.12	lasso	2	0.07	4.8e-04	6.0	5.8	5.7e-09	-0.10	0.36	0.03	TRUE
10	GTEx	Uterus	GIMAP4	0.32	-0.01	enet	42	0.02	1.4e-01	-1.6	-7.7	1.4e-14	0.48	0.05	0.20	FALSE
19	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ABP1	0.26	0.20	enet	10	0.17	1.4e-08	-5.6	-7.0	1.9e-12	0.39	0.95	0.05	FALSE
3	GTEx	Brain Cerebellar Hemisphere	KCNH2	0.34	0.09	lasso	5	0.12	5.0e-04	5.1	-6.8	1.1e-11	0.67	0.02	0.83	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM176A	0.19	0.05	lasso	6	0.13	2.6e-14	-5.9	6.5	1.0e-10	-0.11	0.06	0.94	FALSE
12	METSIM	Adipose	AOC1	0.17	0.08	enet	26	0.11	3.2e-16	5.7	6.5	1.1e-10	-0.30	1.00	0.00	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	TMEM176A	0.25	0.17	enet	19	0.20	1.5e-25	4.2	6.4	1.6e-10	-0.09	1.00	0.00	FALSE
6	GTEx	Esophagus Mucosa	SLC4A2	0.11	0.03	enet	8	0.06	5.1e-05	6.3	6.4	2.0e-10	-0.23	0.86	0.02	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TMEM176A	0.07	0.04	lasso	8	0.03	7.0e-05	6.0	6.3	2.7e-10	-0.18	0.68	0.03	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	TMUB1	0.05	0.01	bslmm	511	0.01	7.2e-03	5.5	-5.8	7.2e-09	0.31	0.09	0.06	FALSE
16	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TMEM176A	0.06	0.01	blup	60	0.03	1.0e-03	5.5	5.8	7.8e-09	-0.17	0.06	0.18	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	RP11-148K1.12	0.17	0.16	lasso	4	0.16	5.2e-20	5.5	5.7	9.6e-09	-0.26	1.00	0.00	FALSE
7	GTEx	Heart Atrial Appendage	TMEM176B	0.37	0.06	enet	15	0.23	1.1e-10	-1.5	-5.7	1.1e-08	0.34	0.55	0.10	FALSE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM176A	0.15	0.01	blup	60	0.04	6.1e-05	8.7	5.6	2.3e-08	-0.17	0.07	0.69	FALSE
11	GTEx	Whole Blood	AGAP3	0.09	0.04	lasso	4	0.03	1.3e-03	5.5	-5.6	2.5e-08	0.14	0.84	0.00	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ABP1	0.16	0.19	lasso	4	0.20	9.3e-22	-5.9	5.4	5.5e-08	-0.25	1.00	0.00	FALSE
8	GTEx	Muscle Skeletal	AGAP3	0.10	0.04	lasso	5	0.03	8.5e-04	5.9	-5.4	8.4e-08	0.13	0.66	0.03	FALSE
9	GTEx	Thyroid	SMARCD3	0.10	0.01	lasso	3	0.01	3.5e-02	5.5	5.3	1.4e-07	-0.13	0.23	0.03	FALSE