[Hub]/) : Traits : Leg fat-free mass (right) :

chr7:149,577,591-151,668,435

Best TWAS P=2.68e-22 · Best GWAS P=2.33e-33 conditioned to 0.00557

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex TMEM176A 0.07 0.04 lasso 8 0.03 7.0e-05 6.0 6.3 2.7e-10 -0.18 0.68 0.03 FALSE
2 GTEx Artery Coronary RP11-148K1.12 0.31 -0.01 enet 16 0.00 2.2e-01 5.5 -6.7 2.0e-11 0.17 0.08 0.06 TRUE
3 GTEx Brain Cerebellar Hemisphere KCNH2 0.34 0.09 lasso 5 0.12 5.0e-04 5.1 -6.8 1.1e-11 0.67 0.02 0.83 FALSE
4 GTEx Brain Cerebellum KCNH2 0.35 0.20 enet 24 0.28 4.8e-09 -11.4 -9.7 2.7e-22 0.83 0.00 1.00 TRUE
5 GTEx Colon Transverse ABCB8 0.17 0.12 lasso 2 0.07 4.8e-04 6.0 5.8 5.7e-09 -0.10 0.36 0.03 TRUE
6 GTEx Esophagus Mucosa SLC4A2 0.11 0.03 enet 8 0.06 5.1e-05 6.3 6.4 2.0e-10 -0.23 0.86 0.02 FALSE
7 GTEx Heart Atrial Appendage TMEM176B 0.37 0.06 enet 15 0.23 1.1e-10 -1.5 -5.7 1.1e-08 0.34 0.55 0.10 FALSE
8 GTEx Muscle Skeletal AGAP3 0.10 0.04 lasso 5 0.03 8.5e-04 5.9 -5.4 8.4e-08 0.13 0.66 0.03 FALSE
9 GTEx Thyroid SMARCD3 0.10 0.01 lasso 3 0.01 3.5e-02 5.5 5.3 1.4e-07 -0.13 0.23 0.03 FALSE
10 GTEx Uterus GIMAP4 0.32 -0.01 enet 42 0.02 1.4e-01 -1.6 -7.7 1.4e-14 0.48 0.05 0.20 FALSE
11 GTEx Whole Blood AGAP3 0.09 0.04 lasso 4 0.03 1.3e-03 5.5 -5.6 2.5e-08 0.14 0.84 0.00 FALSE
12 METSIM Adipose AOC1 0.17 0.08 enet 26 0.11 3.2e-16 5.7 6.5 1.1e-10 -0.30 1.00 0.00 FALSE
13 ROSMAP Brain Pre-frontal Cortex TMEM176A 0.25 0.17 enet 19 0.20 1.5e-25 4.2 6.4 1.6e-10 -0.09 1.00 0.00 FALSE
14 ROSMAP Brain Pre-frontal Cortex TMUB1 0.05 0.01 bslmm 511 0.01 7.2e-03 5.5 -5.8 7.2e-09 0.31 0.09 0.06 FALSE
15 ROSMAP Brain Pre-frontal Cortex RP11-148K1.12 0.17 0.16 lasso 4 0.16 5.2e-20 5.5 5.7 9.6e-09 -0.26 1.00 0.00 FALSE
16 The Cancer Genome Atlas Bladder Urothelial Carcinoma TMEM176A 0.06 0.01 blup 60 0.03 1.0e-03 5.5 5.8 7.8e-09 -0.17 0.06 0.18 FALSE
17 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ABP1 0.16 0.19 lasso 4 0.20 9.3e-22 -5.9 5.4 5.5e-08 -0.25 1.00 0.00 FALSE
18 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TMEM176A 0.19 0.05 lasso 6 0.13 2.6e-14 -5.9 6.5 1.0e-10 -0.11 0.06 0.94 FALSE
19 The Cancer Genome Atlas Liver Hepatocellular Carcinoma ABP1 0.26 0.20 enet 10 0.17 1.4e-08 -5.6 -7.0 1.9e-12 0.39 0.95 0.05 FALSE
20 The Cancer Genome Atlas Prostate Adenocarcinoma TMEM176A 0.15 0.01 blup 60 0.04 6.1e-05 8.7 5.6 2.3e-08 -0.17 0.07 0.69 FALSE
21 The Cancer Genome Atlas Testicular Germ Cell Tumors TMEM176A 0.15 0.00 lasso 10 0.02 5.7e-02 8.7 7.3 3.1e-13 -0.24 0.01 0.31 TRUE