Hub : Genes

ABP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.163	0.0407	5.6e-17	0.191	0.185	0.182	NA	0.197	4.5e-21	2.5e-20	4.7e-20	NA	9.3e-22
2	TCGA	Kidney Renal Papillary Cell Carcinoma	0.149	0.0620	7.0e-05	0.084	0.098	0.105	NA	0.131	1.6e-05	2.9e-06	1.4e-06	NA	6.0e-08
3	TCGA	Liver Hepatocellular Carcinoma	0.258	0.0740	6.4e-08	0.195	0.161	0.174	NA	0.171	1.6e-09	5.2e-08	1.4e-08	NA	1.9e-08
4	TCGA	Pancreatic Adenocarcinoma	0.127	0.0630	2.0e-03	0.027	0.048	0.043	NA	0.022	2.5e-02	4.4e-03	6.5e-03	NA	4.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.4	0.6	1.0	1.0	0.9	-0.8	-0.0
Bipolar Disorder or Schizophrenia	0.2	0.4	1.5	0.2	-0.2	0.5	-1.2
Depressed Affect (Nagel 2018)	0.4	0.8	1.1	-0.7	-1.0	1.0	-0.8
Depression (Nagel 2018)	0.2	0.3	0.7	-0.3	-0.9	0.0	-0.7
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.8	0.6	1.4	-0.2	0.2
Neuroticism (Nagel 2018)	1.3	3.1	4.7	-1.5	-1.8	1.5	-2.2
Schizophrenia (2018)	0.6	1.3	2.4	-0.6	-1.0	1.2	-1.6
Schizophrenia vs Biploar Disorder	0.4	0.5	1.9	-0.2	-0.4	0.2	-1.4
Worry (Nagel 2018)	2.0	4.1	6.1	-1.7	-2.3	1.4	-2.5
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	-0.2	-0.0	0.4	0.8
Alzheimer’s Disease (in father)	1.5	1.6	4.4	0.7	-0.2	-1.2	-2.1
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	-0.0	-0.0	-0.3	-0.5
Crohns Disease (2017)	0.6	1.2	2.2	1.1	1.2	-1.5	-0.2
Irritable Bowel Disease (IBD)	0.1	0.3	1.2	0.0	-0.1	-0.2	-1.1
Ulcerative Colitis (UC)	0.8	1.5	2.4	-1.4	-1.1	1.6	-0.6
Major Depression (MDD)	0.2	0.2	0.3	0.5	0.5	-0.5	0.2
Reaction Time	1.2	2.3	4.5	-2.1	-1.4	1.6	-0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.2	1.1	1.1	0.1	-0.2
Breast Cancer	2.0	4.8	10.2	3.2	1.8	-2.4	0.4
Ovarian Cancer	1.0	1.4	4.9	-0.5	-0.6	-0.2	2.2
Prostate Cancer	0.6	0.8	1.2	1.0	1.1	-0.8	0.8
Age at First Birth	0.4	0.6	0.9	-0.8	-0.7	0.9	0.7
Bipolar Disorder (2011)	0.8	0.7	1.4	1.2	1.1	-0.1	0.6
Body Mass Index (BMI) (2010)	0.8	1.1	2.6	0.8	0.9	-1.6	-0.7
Coronary Artery Disease (CAD)	3.1	3.7	8.7	-3.0	-2.1	1.3	-0.4
Crohns Disease (2012)	1.1	1.7	2.5	0.9	1.6	-1.2	-1.4
Mean Putamen Volume	0.2	0.3	0.6	0.0	-0.5	0.8	-0.5
Fasting Glucose	0.4	0.4	1.4	0.5	-0.2	0.3	-1.2
HbA1C	0.1	0.1	0.3	-0.2	-0.3	-0.6	-0.2
HDL Cholesterol	2.2	3.7	8.8	-2.0	-1.2	3.0	0.8
LDL Cholesterol	0.1	0.1	0.1	-0.2	0.3	0.3	-0.3
Lupus	1.0	1.6	3.7	0.9	1.1	-0.7	1.9
Neuroticism (2016)	1.3	1.8	3.0	-1.7	-1.2	1.7	-0.1
Primary Biliary Cirrhosis	0.6	0.9	2.9	0.8	1.7	-0.2	-0.4
Rheumatoid Arthritis	0.5	0.6	1.1	0.6	1.0	-0.3	1.0
Schizophrenia (2014)	0.7	1.5	5.3	0.1	-0.5	0.6	-2.3
Triglycerides	0.9	1.4	3.1	1.3	0.6	-1.8	-0.7
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.0	0.5	-0.2	0.5
Ulcerative Colitis	0.4	0.5	1.6	-0.4	-0.1	0.6	-1.3
Blood Eosinophil Count	0.2	1.2	2.7	-0.5	-1.0	-0.9	-1.6
Blood Platelet Count	1.0	11.3	15.4	3.9	3.9	-3.9	-0.0
Blood Red Count	0.2	2.0	5.7	-0.3	-1.4	0.2	-2.4
Blood White Count	0.2	1.5	4.5	1.1	0.5	-2.1	-0.2
Heel T-Score	0.7	5.7	15.8	0.3	-2.6	-0.2	-4.0
BMI	0.2	1.1	2.7	-1.1	-0.6	-0.5	1.6
Height	4.9	93.6	146.4	12.1	4.8	-11.9	-7.9
Waist Hip Ratio (WHR)	0.3	1.2	2.5	-0.7	-1.1	0.8	-1.6
Systolic Blood Pressure	0.1	0.6	1.9	-0.4	-0.3	-0.6	1.4
Smoking Status	0.3	0.7	1.8	-0.4	-0.7	-1.3	-0.6
Allergy or Eczema	0.7	1.7	3.5	-1.2	-1.9	1.3	-0.4
Cardiovascular Disease	0.6	2.0	5.1	0.0	-0.2	-1.7	-2.3
Hypothyroidism (self reported)	0.9	2.1	2.8	1.2	1.6	-1.7	1.3
Respiratory disease	0.1	0.3	0.6	-0.4	-0.8	-0.0	-0.4
Type 2 Diabetes (T2D) (2018)	5.2	9.7	15.7	3.0	2.2	-3.1	-4.0
Lung FEV1/FVC ratio	0.1	0.7	1.1	-1.1	-0.7	1.0	0.5
Lung FVC	1.8	9.1	16.8	4.1	2.0	-3.4	-2.0
Neuroticism	0.7	1.7	5.4	-0.3	-1.0	0.2	-2.3
Chronotype (morning person)	1.2	2.8	5.4	2.0	1.3	-2.3	-0.6
Hair Pigment	0.1	1.8	2.7	1.4	1.5	-1.6	-0.6
Tanning	0.0	0.5	0.8	0.9	0.5	-0.8	-0.6
Hand grip strength (left)	6.0	15.8	21.8	4.7	2.4	-4.6	-3.8
Number of treatments/medications taken	0.8	1.5	3.1	-1.8	-1.6	0.2	0.1
Average weekly spirits intake	0.8	1.0	1.6	1.3	0.9	-1.0	0.8
Sensitivity / hurt feelings	0.7	1.2	3.1	-0.8	-1.0	0.3	-1.8
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.4	-0.7	-0.5	0.1	-0.6
Hearing difficulty/problems: Yes	0.4	0.7	1.9	-0.6	-0.1	0.6	1.4
Relative age of first facial hair	0.8	1.7	4.7	1.4	2.2	-0.6	0.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.4	1.2	0.1	-1.5	-0.7
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.4	0.7	0.0	-1.6	-0.1
Ever had hysterectomy (womb removed)	2.5	2.8	3.8	-1.9	-2.0	1.9	-0.1
Systolic blood pressure, automated reading	0.7	2.1	8.1	-0.2	-0.0	0.3	2.8
Eye problems/disorders: Diabetes related eye disease	1.7	1.8	6.5	-0.5	-0.3	-0.7	-2.5
Angina	1.2	1.5	4.1	0.2	-0.0	-1.4	-2.0
Medication for hormone replacement therapy	0.1	0.2	0.4	-0.4	-0.6	0.3	0.2
Vitamin and mineral supplements	0.2	0.2	0.4	-0.4	-0.2	0.4	0.7
Supplements: Zinc	1.0	1.1	4.3	-0.1	-0.1	-0.2	-2.1
Medication: Co-codamol	0.6	0.7	1.7	-1.3	-0.5	0.6	0.6
Medication: Metformin	1.3	1.8	6.0	0.8	0.1	-0.8	-2.4
Diabetes (father)	1.4	1.7	3.6	-1.2	-1.9	1.3	-0.2
Diabetes (mother)	1.9	2.5	4.3	1.2	0.8	-1.8	-2.1
Severe depression (siblings)	0.8	0.9	1.2	-1.1	-0.9	0.9	0.8
Pack years adult smoking proportion	0.4	0.7	1.3	-1.1	-0.7	1.0	0.1
Impedance of leg (right)	4.7	22.6	38.0	-4.7	-2.1	6.2	5.0
Leg fat-free mass (left)	4.1	22.0	44.9	5.1	2.3	-6.7	-3.5
Trunk fat percentage	2.0	8.0	18.7	-2.8	-1.4	1.8	4.3
Hand grip strength (right)	3.6	9.7	15.0	3.3	1.4	-3.3	-3.9
Townsend deprivation index at recruitment	0.2	0.2	0.6	-0.8	-0.2	-0.2	0.4
Current tobacco smoking	0.5	0.8	1.8	-0.8	-0.1	-1.3	-0.9
Average weekly fortified wine intake	1.4	1.7	2.8	-1.3	-1.7	1.4	-0.6
Maternal smoking around birth	0.2	0.3	0.6	0.5	0.5	-0.8	0.5
Fed-up feelings	0.1	0.2	0.6	-0.2	0.2	-0.8	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.4	-0.0	0.6	-0.4	-0.6
Relative age voice broke	0.2	0.2	0.3	0.5	0.3	-0.5	-0.6
Taking other prescription medications	1.0	1.5	2.9	1.1	1.7	-1.4	-0.3
Age when periods started (menarche)	1.1	2.7	7.0	-0.9	-0.2	1.7	2.6
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	3.0	-1.4	-1.5	0.4	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	2.6	-1.6	-1.6	0.8	-1.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.4	0.6	0.6	-1.2	0.7
Qualifications: CSEs or equivalent	1.3	1.8	3.5	-1.9	-1.3	1.3	0.4
Serious illness, injury or assault to yourself	0.1	0.2	0.2	-0.3	-0.4	-0.4	-0.4
High blood pressure	1.1	3.2	7.5	1.3	0.5	-2.7	-1.8
Hayfever, allergic rhinitis or eczema	1.2	2.6	4.2	-1.8	-1.5	2.0	0.7
Multivitamins +/- minerals	0.1	0.1	0.3	-0.1	-0.2	-0.1	-0.6
Stomach or abdominal pain in last month	1.0	1.2	2.4	0.3	1.3	-1.5	0.7
Supplements: Glucosamine	0.7	0.9	1.5	-1.1	-1.2	0.8	-0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	0.6	0.3	-0.3	0.1
Medication: Atenolol	1.4	1.7	3.3	1.1	0.6	-1.8	-1.4
Medication: Levothyroxine sodium	2.4	4.1	6.4	2.1	2.5	-2.0	1.3
Sitting height	6.2	43.7	73.1	7.3	3.0	-8.6	-6.2
Chronic bronchitis/emphysema (father)	0.4	0.4	1.7	-0.1	-1.3	0.2	0.1
High blood pressure (mother)	3.1	4.4	6.7	1.8	1.2	-2.6	-2.4
Body mass index (BMI)	0.4	1.6	3.8	0.3	0.3	-2.0	1.6
Impedance of leg (left)	4.9	24.0	39.9	-5.1	-2.5	6.3	4.9
Leg predicted mass (left)	4.2	22.2	45.4	5.1	2.3	-6.7	-3.5
Trunk fat mass	0.4	1.7	5.9	-0.4	-0.2	-1.0	2.4
Waist circumference	1.0	3.7	10.6	1.8	0.9	-3.2	-0.0
Number of incorrect matches in round	0.7	1.2	1.6	1.0	0.9	-1.1	-1.2
Past tobacco smoking	0.4	0.8	2.6	-0.5	0.0	1.6	0.7
Alcohol usually taken with meals	0.6	0.9	1.6	-1.1	-0.9	1.3	-0.1
Nervous feelings	1.6	3.0	4.0	-1.9	-2.0	1.9	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	4.1	-0.4	-0.1	-0.1	-2.0
Hearing difficulty/problems with background noise	0.2	0.4	0.8	-0.8	-0.9	0.1	0.2
Hair/balding pattern: Pattern 2	2.4	3.1	4.4	-2.1	-1.9	2.0	0.6
Had menopause	0.4	0.4	1.0	0.5	-0.5	0.6	1.0
Had other major operations	2.9	3.6	5.5	2.3	1.2	-1.7	-2.1
Forced vital capacity (FVC)	3.2	12.2	20.8	4.6	2.1	-4.0	-2.8
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.8	-0.6	-1.1	0.5	-1.7
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	2.6	-1.4	-1.6	1.3	0.1
Qualifications: None of the above	0.1	0.3	0.5	-0.7	-0.6	-0.1	-0.4
Financial difficulties in last 2 years	0.7	0.9	2.4	-1.0	-0.5	-0.0	-1.5
Mouth/teeth dental problems	0.3	0.5	1.0	1.0	0.3	0.6	0.9
Heart attack	0.8	1.0	1.6	-0.6	-0.9	-1.3	-1.0
Allergy	0.8	1.8	3.0	1.7	1.2	-1.5	-0.5
Pain all over the body in last month	1.3	1.4	2.6	-1.4	-1.1	1.6	0.1
Diabetes (self-reported)	5.7	8.8	15.9	2.7	2.0	-2.9	-4.0
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.7	-1.2	-0.0	1.1	1.3
Medication: Ramipril	0.6	0.7	2.0	-0.4	-0.3	-0.8	-1.4
Medication: Simvastatin	1.8	2.7	6.6	1.2	0.7	-1.5	-2.6
Fluid intelligence score	0.7	1.5	4.6	1.2	2.1	-0.0	-0.1
Illnesses of siblings	2.8	4.0	10.3	-2.0	-0.8	3.2	1.0
Neuroticism score	0.3	0.7	2.1	-0.5	-0.7	0.2	-1.4
Weight	1.9	9.5	24.9	3.2	1.5	-5.0	-0.8
Impedance of arm (right)	5.0	23.3	42.8	-4.9	-2.4	6.5	4.5
Arm fat percentage (right)	1.2	4.6	14.9	-1.8	-0.3	0.6	3.9
Trunk fat-free mass	8.4	48.5	88.4	7.9	3.9	-9.4	-5.3
Hip circumference	1.3	5.6	15.7	2.1	1.4	-4.0	-0.1
Time employed in main current job	0.5	0.6	2.3	-0.3	0.2	-0.2	1.5
Alcohol intake versus 10 years previously	1.0	1.6	5.2	0.3	-0.4	-0.9	-2.3
Father’s age at death	0.5	0.7	1.3	-0.9	-0.8	1.2	0.3
Worrier / anxious feelings	0.2	0.4	1.5	0.3	-0.1	-0.0	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	1.9	-1.1	-1.2	-0.2	-1.4
Falls in the last year	0.4	0.6	1.4	-1.2	-0.6	0.3	0.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.9	0.2	0.3	0.4	-0.9
Number of live births	0.2	0.2	0.6	0.1	0.0	-0.6	-0.8
Forced expiratory volume in 1-second (FEV1)	2.3	7.8	13.0	3.6	1.6	-3.2	-2.3
Pulse rate	1.6	2.7	6.2	-2.5	-1.4	1.6	0.3
Happiness	0.0	0.0	0.1	-0.2	-0.0	-0.2	0.3
Noisy workplace	0.1	0.1	0.3	0.2	-0.1	0.2	0.6
Qualifications: A levels/AS levels or equivalent	1.2	2.7	5.2	2.3	1.5	-0.4	1.8
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.7	-0.4	-0.9	-0.0	-0.8
Mouth/teeth dental problems: Dentures	0.2	0.4	0.9	-0.8	0.0	-1.0	-0.4
Asthma	0.0	0.1	0.3	-0.2	-0.5	0.2	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.7	-0.3	0.0	1.3	-0.3
Medication: Cholesterol lowering	0.8	1.2	4.2	-0.0	-0.5	-0.6	-2.1
Depression (self-reported)	3.4	4.1	7.0	-2.4	-1.8	2.7	0.3
Medication: Lansoprazole	0.9	1.0	1.9	0.8	0.9	-0.8	1.4
Prospective memory result	0.6	0.7	1.9	-0.7	-1.4	0.1	0.7
Lung cancer (father)	0.2	0.2	0.4	-0.2	-0.6	-0.3	0.5
Illnesses of mother	1.4	1.7	5.7	0.2	0.7	0.7	2.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.5	8.6	2.9	1.0	-2.4	-1.5
Pulse wave Arterial Stiffness index	0.6	0.7	1.4	-0.7	-0.3	0.8	1.2
Impedance of arm (left)	5.9	27.2	50.6	-5.6	-2.9	7.1	4.3
Arm fat mass (right)	0.5	2.1	4.4	0.6	0.8	-2.1	1.7
Trunk predicted mass	8.4	48.1	87.2	7.9	3.9	-9.3	-5.2
Standing height	3.2	31.9	49.6	6.8	2.6	-7.0	-5.0
Length of working week for main job	0.5	0.6	1.1	-0.1	0.5	-1.0	1.0
Exposure to tobacco smoke at home	0.1	0.1	0.4	-0.3	0.1	-0.6	-0.3
Breastfed as a baby	0.3	0.4	1.1	0.4	-0.4	-0.6	-1.0
Tense / ‘highly strung’	1.2	2.0	6.9	-0.8	-0.6	0.5	-2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	3.6	-1.9	-1.9	1.8	-1.5
Hair/balding pattern: Pattern 4	3.9	9.4	19.0	3.2	2.8	-4.4	-0.9
Birth weight of first child	0.4	0.8	1.3	-0.3	1.1	0.7	1.1
Peak expiratory flow (PEF)	1.1	2.4	4.5	1.9	1.1	-2.1	-0.6
Pulse wave reflection index	0.1	0.2	0.4	0.2	0.7	-0.2	0.3
Ever highly irritable/argumentative for 2 days	1.6	2.0	5.9	-0.5	-0.9	1.0	-2.4
Loud music exposure frequency	1.7	1.9	3.3	-1.8	-1.6	0.9	-0.9
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	4.2	2.1	1.4	-0.6	0.8
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.5	-0.0	1.1	-0.5	-1.2
Blood clot in the leg (DVT)	1.4	1.8	3.3	-1.8	-1.6	0.6	-1.1
Medication: Paracetamol	1.7	2.9	4.3	-2.1	-1.3	1.5	1.8
Headache pain in last month	0.4	0.6	1.2	-1.1	-0.6	0.8	-0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.8	0.4	0.2	0.5	1.4
Glaucoma (self-reported)	2.0	2.4	3.9	2.0	1.8	-1.6	-0.1
Gout (self-reported)	0.4	0.6	1.5	0.2	-0.4	-0.7	-1.2
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	2.1	1.2	1.4	-1.5	1.4
Medication: Amlodipine	1.3	1.8	3.5	0.8	0.5	-1.9	-1.6
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	0.3	-0.1	-0.1	0.0
Birth weight	0.5	1.0	1.7	-0.7	-1.3	1.3	-0.2
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.1	-1.5	-0.7	0.6	0.6
High blood pressure (siblings)	3.2	4.6	11.8	2.2	1.3	-3.4	-0.3
Forced vital capacity (FVC), Best measure	1.4	5.2	9.7	3.1	0.7	-2.5	-2.1
Body fat percentage	2.1	8.4	21.0	-2.9	-1.3	1.7	4.6
Leg fat percentage (right)	2.1	7.7	23.6	-2.4	-0.6	1.1	4.9
Arm fat-free mass (right)	6.2	32.0	63.7	6.2	2.8	-8.0	-4.2
Exposure to tobacco smoke outside home	0.4	0.6	1.1	0.3	0.9	-1.1	-0.6
Comparative body size at age 10	0.8	2.3	5.6	-2.4	-1.8	0.7	0.4
Number of full brothers	1.5	1.8	3.9	-1.6	-2.0	0.8	-0.0
Worry too long after embarrassment	1.0	1.7	3.9	1.0	0.3	-1.3	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.9	3.8	4.3	-2.1	-1.8	2.1	-1.9
Wheeze or whistling in the chest in last year	1.5	2.7	5.3	-2.3	-1.4	1.3	1.4
Number of children fathered	0.3	0.3	0.6	-0.8	-0.7	0.5	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	0.4	-0.5	-0.0	0.1
Age at first live birth	0.1	0.1	0.2	-0.4	-0.3	0.4	0.4
Pulse wave peak to peak time	1.5	1.8	2.6	1.3	0.7	-1.6	-1.6
Health satisfaction	0.2	0.2	0.3	-0.6	-0.4	-0.4	-0.5
Shortness of breath walking on level ground	0.5	0.6	1.3	-0.1	-1.1	-0.5	0.8
Qualifications: College or University degree	0.2	0.8	2.4	0.5	0.4	0.5	-1.5
Eye problems/disorders: None of the above	1.7	2.0	3.8	-1.5	-0.7	1.2	2.0
Mouth/teeth dental problems: Loose teeth	1.0	1.2	1.9	-1.4	-1.1	1.0	0.7
Emphysema/chronic bronchitis	0.6	0.7	1.5	-1.2	-0.9	0.4	-0.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	0.7	0.5	0.2	0.2
Neck or shoulder pain in last month	0.3	0.4	1.1	-1.1	-0.7	-0.3	-0.2
Medication: Blood pressure	0.4	0.7	1.6	-0.1	0.1	-1.2	-1.0
Angina (self-reported)	1.4	1.9	5.9	0.1	-0.3	-1.2	-2.4
Migraine (self-reported)	0.4	0.5	1.2	-0.7	-1.1	0.5	0.4
Medication: Ibuprofen	0.3	0.4	1.3	0.2	0.1	1.1	0.3
Medication: Allopurinol	1.0	1.3	2.8	-0.6	-1.5	-0.2	-1.7
Medication: Omeprazole	0.9	1.1	2.5	1.0	0.7	-1.6	0.3
Medication: Seretide 50 evohaler	0.4	0.4	1.0	-1.0	-0.6	0.4	-0.5
Mean time to correctly identify matches	0.5	0.9	1.7	-1.3	-0.9	1.0	0.1
Heart disease (mother)	0.6	0.7	1.9	-0.7	-1.4	-0.0	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.0	0.6	1.4	-0.7	1.0
Whole body fat mass	0.5	2.2	5.8	0.2	0.4	-1.7	2.4
Leg fat mass (right)	0.6	2.3	6.7	-0.0	0.4	-1.6	2.6
Arm predicted mass (right)	5.7	29.1	57.5	5.9	2.7	-7.6	-4.1
Pulse rate, automated reading	1.6	5.1	12.5	-3.5	-1.5	2.2	0.9
Alcohol intake frequency.	0.3	0.7	1.6	0.6	0.7	-1.3	-0.2
Comparative height size at age 10	2.4	13.3	22.3	4.0	1.1	-4.7	-3.7
Number of full sisters	0.5	0.6	1.1	1.0	0.7	-0.8	-0.0
Suffer from ‘nerves’	2.8	4.5	7.1	-2.4	-2.7	2.2	0.4
Overall health rating	0.8	1.7	3.5	-1.9	-1.7	0.1	-0.3
Chest pain or discomfort	0.3	0.5	1.0	-0.9	-0.2	-0.2	-1.0
Had major operations	0.5	0.6	2.0	-0.1	0.4	-0.3	-1.4
Age at last live birth	1.1	1.7	2.9	-1.2	-0.1	1.7	1.6
Family relationship satisfaction	0.9	1.1	1.3	-0.9	-1.0	1.2	-1.0
Leg pain on walking	1.1	1.3	2.4	-1.4	-0.8	-0.7	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.5	-0.5	-1.6	0.5	-0.1
Commuting to job workplace: Car/motor vehicle	0.7	0.7	1.2	-0.2	-1.1	0.8	-1.1
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.9	1.7	1.7	-0.8	0.1
Medication: Aspirin	1.3	1.7	3.3	-0.4	-1.1	-1.4	-1.8
Supplements: Vitamin C	1.6	1.8	4.9	-1.2	-0.2	2.2	1.0
Knee pain experienced in last month	2.4	3.7	6.7	-2.6	-2.0	1.7	1.0
Hypertension (Self-reported)	1.0	2.8	6.9	1.2	0.4	-2.6	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.4	0.8	0.8	-0.4	1.2
Illnesses of father: Heart disease	0.0	0.1	0.1	-0.3	0.1	0.2	0.3
Illnesses of siblings: Diabetes	0.9	1.1	1.8	1.2	0.2	-1.4	-1.0
Smoking status: Previous	0.2	0.2	0.5	-0.1	-0.7	-0.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	3.0	6.2	10.3	3.0	1.5	-3.2	-1.8
Whole body fat-free mass	6.7	38.5	72.9	6.9	3.2	-8.5	-4.8
Leg fat-free mass (right)	4.8	25.5	49.6	5.4	2.3	-7.0	-4.2
Arm fat percentage (left)	1.4	5.5	14.7	-2.4	-0.8	1.0	3.8
Average weekly red wine intake	1.3	1.9	3.2	-1.6	-1.8	1.3	0.0
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.6	0.1	0.1	-0.2	0.8
Mood swings	0.1	0.1	0.2	-0.4	-0.4	0.1	0.1
Loneliness, isolation	0.3	0.4	0.9	0.1	-0.1	-0.9	-0.9
Long-standing illness, disability or infirmity	0.1	0.2	0.5	0.0	-0.3	-0.4	-0.7
Ever had bowel cancer screening	1.4	1.6	2.9	1.7	1.2	-1.3	0.7
Diabetes diagnosed by doctor	4.9	8.1	14.6	2.5	1.8	-2.8	-3.8
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	4.3	-1.3	-2.1	1.2	-0.7
Friendships satisfaction	1.6	2.0	3.9	-0.6	-1.7	0.9	-2.0
Qualifications: nursing, teaching	0.4	0.6	0.9	0.9	0.9	0.7	-0.4
Commuting to job workplace: Walk	0.5	0.5	1.0	-0.8	0.0	0.7	1.0
Eye problems/disorders: Cataract	1.1	1.3	4.5	0.6	-0.2	-0.5	-2.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.5	0.8	0.8	-1.2	0.3
Medication for cholesterol	1.2	1.9	5.7	0.1	0.9	0.9	2.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.8	0.3	-0.1	-1.4	-0.2
Back pain experienced in last month	0.7	1.0	1.8	-0.3	0.6	-1.3	1.3
Mineral and other dietary supplements	0.3	0.5	1.0	0.5	0.5	-0.5	-1.0
Breast cancer (self-reported)	2.0	2.4	2.9	1.6	1.7	-1.5	1.4
Asthma (self-reported)	0.0	0.0	0.1	0.2	-0.1	-0.2	-0.0
Osteoporosis (self-reported)	0.4	0.4	0.9	0.8	0.2	-1.0	0.4
Osteoarthritis (self-reported)	2.6	3.4	7.4	-1.5	-1.1	1.6	2.7
Medication: Aspirin	1.1	1.4	2.4	-0.3	-0.9	-1.5	-1.6
Medication: Gliclazide	0.2	0.3	1.0	0.1	1.0	-0.2	0.2
Illnesses of father: None of the above (group 1)	0.5	0.7	2.3	0.5	1.5	-0.1	0.3
Smoking status: Current	0.4	0.7	1.4	-0.8	-0.1	-1.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	3.0	1.7	1.4	-0.6	1.3
Whole body water mass	7.1	40.2	76.0	7.0	3.3	-8.7	-5.0
Leg predicted mass (right)	4.7	25.1	48.7	5.4	2.2	-7.0	-4.2
Arm fat mass (left)	0.5	2.2	5.2	0.6	0.8	-2.3	1.6
Number of self-reported non-cancer illnesses	1.1	1.9	3.5	1.3	0.0	-1.5	-1.9
Average weekly champagne plus white wine intake	0.9	1.3	3.0	-1.1	-0.8	1.7	0.4
Miserableness	0.4	0.7	2.1	-0.7	-0.4	1.4	-0.3
Guilty feelings	0.6	0.9	3.3	0.2	-0.5	0.0	-1.8
Wears glasses or contact lenses	0.5	0.6	1.3	0.4	-1.1	-0.6	-0.7
Ever taken oral contraceptive pill	0.5	0.5	0.9	0.2	-0.5	1.0	-0.9
Hearing aid user	1.3	1.5	5.6	-0.5	-0.2	0.5	2.4
Mother’s age at death	0.5	0.7	2.3	0.4	-0.4	-0.1	-1.5
Financial situation satisfaction	0.5	0.6	1.0	-0.5	-1.0	-0.6	-0.9
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.7	-0.3	-1.6	0.4	-0.8
Commuting to job workplace: Public transport	0.2	0.2	0.4	-0.3	-0.6	-0.2	-0.5
Eye problems/disorders: Glaucoma	1.0	1.2	1.6	1.3	1.2	-1.0	0.8
Medication: Blood pressure	1.1	2.0	4.4	0.5	-0.2	-1.8	-2.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.6	-0.0	0.2	-0.8	1.3
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.1	-0.0	-0.3	0.3	0.0
High cholesterol (Self-reported)	1.0	1.7	4.3	-0.8	-1.2	0.6	-2.1
Medication: Bendroflumethiazide	2.1	3.1	5.5	1.7	1.4	-2.4	-1.5
Medication: Paracetamol	2.3	3.5	4.9	-2.2	-1.6	1.6	2.0
Medication: Lisinopril	1.7	2.2	3.6	1.3	1.0	-1.6	-1.9
Medication: Atorvastatin	0.5	0.7	1.4	-1.0	-0.5	1.2	0.1
Illnesses of father: High blood pressure	0.4	0.4	1.1	0.1	-0.7	-0.4	-1.0
Alcohol drinker status: Never	2.9	3.5	6.1	2.0	2.5	-1.8	0.7
Ever smoked	0.8	1.4	4.0	0.7	0.2	-2.0	-1.0
Basal metabolic rate	5.6	30.9	62.3	6.1	3.0	-7.9	-3.9
Leg fat percentage (left)	2.0	7.1	20.7	-2.4	-0.8	1.1	4.6
Arm fat-free mass (left)	6.6	33.6	66.6	6.5	3.4	-8.2	-3.7
Number of operations (self-reported)	1.5	2.2	3.3	1.6	0.3	-1.8	-1.6
Average weekly beer plus cider intake	0.3	0.5	0.7	0.8	0.4	-0.6	-0.8
Irritability	0.4	0.6	1.7	0.3	0.7	-0.5	-1.3
Risk taking	0.3	0.4	0.8	-0.8	-0.9	0.3	-0.4
Ever had prostate specific antigen (PSA) test	2.5	2.9	5.4	2.3	0.6	-1.6	-1.8
Fractured/broken bones in last 5 years	1.8	2.3	4.5	-1.8	-0.6	2.1	1.2
Age started oral contraceptive pill	0.3	0.3	0.7	-0.4	-0.2	0.7	0.8
Diastolic blood pressure, automated reading	1.1	3.4	10.8	-1.5	-0.3	0.6	3.3
Ever depressed for a whole week	0.6	0.7	1.7	0.1	-1.0	-0.3	-1.3
Unable to work because of sickness or disability	1.3	1.7	3.5	-1.9	-1.2	1.4	0.2
Commuting to job workplace: Cycle	0.1	0.1	0.4	-0.3	-0.1	-0.1	0.6
Myopia	0.9	1.4	2.7	1.6	0.3	-1.4	-0.9
Vascular/heart problems diagnosed by doctor	1.0	2.8	6.8	-0.8	-0.1	2.6	2.0
Cholesterol lowering medication	0.5	0.8	2.8	0.1	0.3	-0.6	-1.7
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	3.8	1.3	1.1	-1.9	1.0
Pain experienced in last month	0.8	1.3	3.7	1.9	0.4	-0.5	-1.1
Supplements: Calcium	0.4	0.4	0.6	0.8	0.5	-0.7	0.5
Basal cell carcinoma (self-reported)	1.9	2.2	3.6	1.8	1.9	-1.4	0.2
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.0	-0.6	-1.1	-1.4	-1.2
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	3.4	-1.9	-1.6	0.8	-0.7
Heart disease (siblings)	0.6	0.8	1.9	-1.0	-1.4	0.3	-0.2
Alcohol drinker status: Previous	0.3	0.3	0.8	-0.0	0.7	0.1	0.9
Pack years of smoking	0.4	0.6	0.9	-0.9	-0.6	1.0	0.2
Impedance of whole body	5.9	30.1	54.3	-5.7	-3.0	7.4	4.9
Leg fat mass (left)	0.5	2.1	5.7	-0.1	0.3	-1.6	2.4
Arm predicted mass (left)	6.3	31.9	63.7	6.3	3.2	-8.0	-3.8