Hub : Genes

ABP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Kidney Renal Clear Cell Carcinoma 0.163 0.0407 5.6e-17 0.191 0.185 0.182 NA 0.197 4.5e-21 2.5e-20 4.7e-20 NA 9.3e-22
2 TCGA Kidney Renal Papillary Cell Carcinoma 0.149 0.0620 7.0e-05 0.084 0.098 0.105 NA 0.131 1.6e-05 2.9e-06 1.4e-06 NA 6.0e-08
3 TCGA Liver Hepatocellular Carcinoma 0.258 0.0740 6.4e-08 0.195 0.161 0.174 NA 0.171 1.6e-09 5.2e-08 1.4e-08 NA 1.9e-08
4 TCGA Pancreatic Adenocarcinoma 0.127 0.0630 2.0e-03 0.027 0.048 0.043 NA 0.022 2.5e-02 4.4e-03 6.5e-03 NA 4.1e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.4 0.6 1.0 1.0 0.9 -0.8 -0.0
Bipolar Disorder or Schizophrenia 0.2 0.4 1.5 0.2 -0.2 0.5 -1.2
Depressed Affect (Nagel 2018) 0.4 0.8 1.1 -0.7 -1.0 1.0 -0.8
Depression (Nagel 2018) 0.2 0.3 0.7 -0.3 -0.9 0.0 -0.7
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.8 0.6 1.4 -0.2 0.2
Neuroticism (Nagel 2018) 1.3 3.1 4.7 -1.5 -1.8 1.5 -2.2
Schizophrenia (2018) 0.6 1.3 2.4 -0.6 -1.0 1.2 -1.6
Schizophrenia vs Biploar Disorder 0.4 0.5 1.9 -0.2 -0.4 0.2 -1.4
Worry (Nagel 2018) 2.0 4.1 6.1 -1.7 -2.3 1.4 -2.5
Alzheimer’s Disease (in mother) 0.2 0.2 0.6 -0.2 -0.0 0.4 0.8
Alzheimer’s Disease (in father) 1.5 1.6 4.4 0.7 -0.2 -1.2 -2.1
Alzheimer’s Disease (including proxy) 0.1 0.1 0.3 -0.0 -0.0 -0.3 -0.5
Crohns Disease (2017) 0.6 1.2 2.2 1.1 1.2 -1.5 -0.2
Irritable Bowel Disease (IBD) 0.1 0.3 1.2 0.0 -0.1 -0.2 -1.1
Ulcerative Colitis (UC) 0.8 1.5 2.4 -1.4 -1.1 1.6 -0.6
Major Depression (MDD) 0.2 0.2 0.3 0.5 0.5 -0.5 0.2
Reaction Time 1.2 2.3 4.5 -2.1 -1.4 1.6 -0.4
Verbal and Numeric Reasoning (VNR) 0.2 0.6 1.2 1.1 1.1 0.1 -0.2
Breast Cancer 2.0 4.8 10.2 3.2 1.8 -2.4 0.4
Ovarian Cancer 1.0 1.4 4.9 -0.5 -0.6 -0.2 2.2
Prostate Cancer 0.6 0.8 1.2 1.0 1.1 -0.8 0.8
Age at First Birth 0.4 0.6 0.9 -0.8 -0.7 0.9 0.7
Bipolar Disorder (2011) 0.8 0.7 1.4 1.2 1.1 -0.1 0.6
Body Mass Index (BMI) (2010) 0.8 1.1 2.6 0.8 0.9 -1.6 -0.7
Coronary Artery Disease (CAD) 3.1 3.7 8.7 -3.0 -2.1 1.3 -0.4
Crohns Disease (2012) 1.1 1.7 2.5 0.9 1.6 -1.2 -1.4
Mean Putamen Volume 0.2 0.3 0.6 0.0 -0.5 0.8 -0.5
Fasting Glucose 0.4 0.4 1.4 0.5 -0.2 0.3 -1.2
HbA1C 0.1 0.1 0.3 -0.2 -0.3 -0.6 -0.2
HDL Cholesterol 2.2 3.7 8.8 -2.0 -1.2 3.0 0.8
LDL Cholesterol 0.1 0.1 0.1 -0.2 0.3 0.3 -0.3
Lupus 1.0 1.6 3.7 0.9 1.1 -0.7 1.9
Neuroticism (2016) 1.3 1.8 3.0 -1.7 -1.2 1.7 -0.1
Primary Biliary Cirrhosis 0.6 0.9 2.9 0.8 1.7 -0.2 -0.4
Rheumatoid Arthritis 0.5 0.6 1.1 0.6 1.0 -0.3 1.0
Schizophrenia (2014) 0.7 1.5 5.3 0.1 -0.5 0.6 -2.3
Triglycerides 0.9 1.4 3.1 1.3 0.6 -1.8 -0.7
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.3 0.0 0.5 -0.2 0.5
Ulcerative Colitis 0.4 0.5 1.6 -0.4 -0.1 0.6 -1.3
Blood Eosinophil Count 0.2 1.2 2.7 -0.5 -1.0 -0.9 -1.6
Blood Platelet Count 1.0 11.3 15.4 3.9 3.9 -3.9 -0.0
Blood Red Count 0.2 2.0 5.7 -0.3 -1.4 0.2 -2.4
Blood White Count 0.2 1.5 4.5 1.1 0.5 -2.1 -0.2
Heel T-Score 0.7 5.7 15.8 0.3 -2.6 -0.2 -4.0
BMI 0.2 1.1 2.7 -1.1 -0.6 -0.5 1.6
Height 4.9 93.6 146.4 12.1 4.8 -11.9 -7.9
Waist Hip Ratio (WHR) 0.3 1.2 2.5 -0.7 -1.1 0.8 -1.6
Systolic Blood Pressure 0.1 0.6 1.9 -0.4 -0.3 -0.6 1.4
Smoking Status 0.3 0.7 1.8 -0.4 -0.7 -1.3 -0.6
Allergy or Eczema 0.7 1.7 3.5 -1.2 -1.9 1.3 -0.4
Cardiovascular Disease 0.6 2.0 5.1 0.0 -0.2 -1.7 -2.3
Hypothyroidism (self reported) 0.9 2.1 2.8 1.2 1.6 -1.7 1.3
Respiratory disease 0.1 0.3 0.6 -0.4 -0.8 -0.0 -0.4
Type 2 Diabetes (T2D) (2018) 5.2 9.7 15.7 3.0 2.2 -3.1 -4.0
Lung FEV1/FVC ratio 0.1 0.7 1.1 -1.1 -0.7 1.0 0.5
Lung FVC 1.8 9.1 16.8 4.1 2.0 -3.4 -2.0
Neuroticism 0.7 1.7 5.4 -0.3 -1.0 0.2 -2.3
Chronotype (morning person) 1.2 2.8 5.4 2.0 1.3 -2.3 -0.6
Hair Pigment 0.1 1.8 2.7 1.4 1.5 -1.6 -0.6
Tanning 0.0 0.5 0.8 0.9 0.5 -0.8 -0.6
Hand grip strength (left) 6.0 15.8 21.8 4.7 2.4 -4.6 -3.8
Number of treatments/medications taken 0.8 1.5 3.1 -1.8 -1.6 0.2 0.1
Average weekly spirits intake 0.8 1.0 1.6 1.3 0.9 -1.0 0.8
Sensitivity / hurt feelings 0.7 1.2 3.1 -0.8 -1.0 0.3 -1.8
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.4 -0.7 -0.5 0.1 -0.6
Hearing difficulty/problems: Yes 0.4 0.7 1.9 -0.6 -0.1 0.6 1.4
Relative age of first facial hair 0.8 1.7 4.7 1.4 2.2 -0.6 0.1
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 2.4 1.2 0.1 -1.5 -0.7
Ever used hormone-replacement therapy (HRT) 0.6 0.7 2.4 0.7 0.0 -1.6 -0.1
Ever had hysterectomy (womb removed) 2.5 2.8 3.8 -1.9 -2.0 1.9 -0.1
Systolic blood pressure, automated reading 0.7 2.1 8.1 -0.2 -0.0 0.3 2.8
Eye problems/disorders: Diabetes related eye disease 1.7 1.8 6.5 -0.5 -0.3 -0.7 -2.5
Angina 1.2 1.5 4.1 0.2 -0.0 -1.4 -2.0
Medication for hormone replacement therapy 0.1 0.2 0.4 -0.4 -0.6 0.3 0.2
Vitamin and mineral supplements 0.2 0.2 0.4 -0.4 -0.2 0.4 0.7
Supplements: Zinc 1.0 1.1 4.3 -0.1 -0.1 -0.2 -2.1
Medication: Co-codamol 0.6 0.7 1.7 -1.3 -0.5 0.6 0.6
Medication: Metformin 1.3 1.8 6.0 0.8 0.1 -0.8 -2.4
Diabetes (father) 1.4 1.7 3.6 -1.2 -1.9 1.3 -0.2
Diabetes (mother) 1.9 2.5 4.3 1.2 0.8 -1.8 -2.1
Severe depression (siblings) 0.8 0.9 1.2 -1.1 -0.9 0.9 0.8
Pack years adult smoking proportion 0.4 0.7 1.3 -1.1 -0.7 1.0 0.1
Impedance of leg (right) 4.7 22.6 38.0 -4.7 -2.1 6.2 5.0
Leg fat-free mass (left) 4.1 22.0 44.9 5.1 2.3 -6.7 -3.5
Trunk fat percentage 2.0 8.0 18.7 -2.8 -1.4 1.8 4.3
Hand grip strength (right) 3.6 9.7 15.0 3.3 1.4 -3.3 -3.9
Townsend deprivation index at recruitment 0.2 0.2 0.6 -0.8 -0.2 -0.2 0.4
Current tobacco smoking 0.5 0.8 1.8 -0.8 -0.1 -1.3 -0.9
Average weekly fortified wine intake 1.4 1.7 2.8 -1.3 -1.7 1.4 -0.6
Maternal smoking around birth 0.2 0.3 0.6 0.5 0.5 -0.8 0.5
Fed-up feelings 0.1 0.2 0.6 -0.2 0.2 -0.8 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.4 -0.0 0.6 -0.4 -0.6
Relative age voice broke 0.2 0.2 0.3 0.5 0.3 -0.5 -0.6
Taking other prescription medications 1.0 1.5 2.9 1.1 1.7 -1.4 -0.3
Age when periods started (menarche) 1.1 2.7 7.0 -0.9 -0.2 1.7 2.6
Bilateral oophorectomy (both ovaries removed) 1.6 1.9 3.0 -1.4 -1.5 0.4 -1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.7 2.6 -1.6 -1.6 0.8 -1.1
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.4 0.6 0.6 -1.2 0.7
Qualifications: CSEs or equivalent 1.3 1.8 3.5 -1.9 -1.3 1.3 0.4
Serious illness, injury or assault to yourself 0.1 0.2 0.2 -0.3 -0.4 -0.4 -0.4
High blood pressure 1.1 3.2 7.5 1.3 0.5 -2.7 -1.8
Hayfever, allergic rhinitis or eczema 1.2 2.6 4.2 -1.8 -1.5 2.0 0.7
Multivitamins +/- minerals 0.1 0.1 0.3 -0.1 -0.2 -0.1 -0.6
Stomach or abdominal pain in last month 1.0 1.2 2.4 0.3 1.3 -1.5 0.7
Supplements: Glucosamine 0.7 0.9 1.5 -1.1 -1.2 0.8 -0.4
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.4 0.6 0.3 -0.3 0.1
Medication: Atenolol 1.4 1.7 3.3 1.1 0.6 -1.8 -1.4
Medication: Levothyroxine sodium 2.4 4.1 6.4 2.1 2.5 -2.0 1.3
Sitting height 6.2 43.7 73.1 7.3 3.0 -8.6 -6.2
Chronic bronchitis/emphysema (father) 0.4 0.4 1.7 -0.1 -1.3 0.2 0.1
High blood pressure (mother) 3.1 4.4 6.7 1.8 1.2 -2.6 -2.4
Body mass index (BMI) 0.4 1.6 3.8 0.3 0.3 -2.0 1.6
Impedance of leg (left) 4.9 24.0 39.9 -5.1 -2.5 6.3 4.9
Leg predicted mass (left) 4.2 22.2 45.4 5.1 2.3 -6.7 -3.5
Trunk fat mass 0.4 1.7 5.9 -0.4 -0.2 -1.0 2.4
Waist circumference 1.0 3.7 10.6 1.8 0.9 -3.2 -0.0
Number of incorrect matches in round 0.7 1.2 1.6 1.0 0.9 -1.1 -1.2
Past tobacco smoking 0.4 0.8 2.6 -0.5 0.0 1.6 0.7
Alcohol usually taken with meals 0.6 0.9 1.6 -1.1 -0.9 1.3 -0.1
Nervous feelings 1.6 3.0 4.0 -1.9 -2.0 1.9 -1.1
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 4.1 -0.4 -0.1 -0.1 -2.0
Hearing difficulty/problems with background noise 0.2 0.4 0.8 -0.8 -0.9 0.1 0.2
Hair/balding pattern: Pattern 2 2.4 3.1 4.4 -2.1 -1.9 2.0 0.6
Had menopause 0.4 0.4 1.0 0.5 -0.5 0.6 1.0
Had other major operations 2.9 3.6 5.5 2.3 1.2 -1.7 -2.1
Forced vital capacity (FVC) 3.2 12.2 20.8 4.6 2.1 -4.0 -2.8
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 2.8 -0.6 -1.1 0.5 -1.7
Ever unenthusiastic/disinterested for a whole week 1.3 1.6 2.6 -1.4 -1.6 1.3 0.1
Qualifications: None of the above 0.1 0.3 0.5 -0.7 -0.6 -0.1 -0.4
Financial difficulties in last 2 years 0.7 0.9 2.4 -1.0 -0.5 -0.0 -1.5
Mouth/teeth dental problems 0.3 0.5 1.0 1.0 0.3 0.6 0.9
Heart attack 0.8 1.0 1.6 -0.6 -0.9 -1.3 -1.0
Allergy 0.8 1.8 3.0 1.7 1.2 -1.5 -0.5
Pain all over the body in last month 1.3 1.4 2.6 -1.4 -1.1 1.6 0.1
Diabetes (self-reported) 5.7 8.8 15.9 2.7 2.0 -2.9 -4.0
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 1.7 -1.2 -0.0 1.1 1.3
Medication: Ramipril 0.6 0.7 2.0 -0.4 -0.3 -0.8 -1.4
Medication: Simvastatin 1.8 2.7 6.6 1.2 0.7 -1.5 -2.6
Fluid intelligence score 0.7 1.5 4.6 1.2 2.1 -0.0 -0.1
Illnesses of siblings 2.8 4.0 10.3 -2.0 -0.8 3.2 1.0
Neuroticism score 0.3 0.7 2.1 -0.5 -0.7 0.2 -1.4
Weight 1.9 9.5 24.9 3.2 1.5 -5.0 -0.8
Impedance of arm (right) 5.0 23.3 42.8 -4.9 -2.4 6.5 4.5
Arm fat percentage (right) 1.2 4.6 14.9 -1.8 -0.3 0.6 3.9
Trunk fat-free mass 8.4 48.5 88.4 7.9 3.9 -9.4 -5.3
Hip circumference 1.3 5.6 15.7 2.1 1.4 -4.0 -0.1
Time employed in main current job 0.5 0.6 2.3 -0.3 0.2 -0.2 1.5
Alcohol intake versus 10 years previously 1.0 1.6 5.2 0.3 -0.4 -0.9 -2.3
Father’s age at death 0.5 0.7 1.3 -0.9 -0.8 1.2 0.3
Worrier / anxious feelings 0.2 0.4 1.5 0.3 -0.1 -0.0 -1.2
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 1.9 -1.1 -1.2 -0.2 -1.4
Falls in the last year 0.4 0.6 1.4 -1.2 -0.6 0.3 0.7
Hair/balding pattern: Pattern 3 0.2 0.3 0.9 0.2 0.3 0.4 -0.9
Number of live births 0.2 0.2 0.6 0.1 0.0 -0.6 -0.8
Forced expiratory volume in 1-second (FEV1) 2.3 7.8 13.0 3.6 1.6 -3.2 -2.3
Pulse rate 1.6 2.7 6.2 -2.5 -1.4 1.6 0.3
Happiness 0.0 0.0 0.1 -0.2 -0.0 -0.2 0.3
Noisy workplace 0.1 0.1 0.3 0.2 -0.1 0.2 0.6
Qualifications: A levels/AS levels or equivalent 1.2 2.7 5.2 2.3 1.5 -0.4 1.8
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.7 -0.4 -0.9 -0.0 -0.8
Mouth/teeth dental problems: Dentures 0.2 0.4 0.9 -0.8 0.0 -1.0 -0.4
Asthma 0.0 0.1 0.3 -0.2 -0.5 0.2 0.0
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.7 -0.3 0.0 1.3 -0.3
Medication: Cholesterol lowering 0.8 1.2 4.2 -0.0 -0.5 -0.6 -2.1
Depression (self-reported) 3.4 4.1 7.0 -2.4 -1.8 2.7 0.3
Medication: Lansoprazole 0.9 1.0 1.9 0.8 0.9 -0.8 1.4
Prospective memory result 0.6 0.7 1.9 -0.7 -1.4 0.1 0.7
Lung cancer (father) 0.2 0.2 0.4 -0.2 -0.6 -0.3 0.5
Illnesses of mother 1.4 1.7 5.7 0.2 0.7 0.7 2.4
Forced expiratory volume in 1-second (FEV1), Best measure 1.4 4.5 8.6 2.9 1.0 -2.4 -1.5
Pulse wave Arterial Stiffness index 0.6 0.7 1.4 -0.7 -0.3 0.8 1.2
Impedance of arm (left) 5.9 27.2 50.6 -5.6 -2.9 7.1 4.3
Arm fat mass (right) 0.5 2.1 4.4 0.6 0.8 -2.1 1.7
Trunk predicted mass 8.4 48.1 87.2 7.9 3.9 -9.3 -5.2
Standing height 3.2 31.9 49.6 6.8 2.6 -7.0 -5.0
Length of working week for main job 0.5 0.6 1.1 -0.1 0.5 -1.0 1.0
Exposure to tobacco smoke at home 0.1 0.1 0.4 -0.3 0.1 -0.6 -0.3
Breastfed as a baby 0.3 0.4 1.1 0.4 -0.4 -0.6 -1.0
Tense / ‘highly strung’ 1.2 2.0 6.9 -0.8 -0.6 0.5 -2.6
Seen doctor (GP) for nerves, anxiety, tension or depression 2.1 3.2 3.6 -1.9 -1.9 1.8 -1.5
Hair/balding pattern: Pattern 4 3.9 9.4 19.0 3.2 2.8 -4.4 -0.9
Birth weight of first child 0.4 0.8 1.3 -0.3 1.1 0.7 1.1
Peak expiratory flow (PEF) 1.1 2.4 4.5 1.9 1.1 -2.1 -0.6
Pulse wave reflection index 0.1 0.2 0.4 0.2 0.7 -0.2 0.3
Ever highly irritable/argumentative for 2 days 1.6 2.0 5.9 -0.5 -0.9 1.0 -2.4
Loud music exposure frequency 1.7 1.9 3.3 -1.8 -1.6 0.9 -0.9
Qualifications: O levels/GCSEs or equivalent 1.1 1.8 4.2 2.1 1.4 -0.6 0.8
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.5 -0.0 1.1 -0.5 -1.2
Blood clot in the leg (DVT) 1.4 1.8 3.3 -1.8 -1.6 0.6 -1.1
Medication: Paracetamol 1.7 2.9 4.3 -2.1 -1.3 1.5 1.8
Headache pain in last month 0.4 0.6 1.2 -1.1 -0.6 0.8 -0.6
Medication for cholesterol, blood pressure or diabetes 0.3 0.6 1.8 0.4 0.2 0.5 1.4
Glaucoma (self-reported) 2.0 2.4 3.9 2.0 1.8 -1.6 -0.1
Gout (self-reported) 0.4 0.6 1.5 0.2 -0.4 -0.7 -1.2
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 2.1 1.2 1.4 -1.5 1.4
Medication: Amlodipine 1.3 1.8 3.5 0.8 0.5 -1.9 -1.6
Medication: Ventolin 100micrograms inhaler 0.0 0.0 0.1 0.3 -0.1 -0.1 0.0
Birth weight 0.5 1.0 1.7 -0.7 -1.3 1.3 -0.2
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.1 -1.5 -0.7 0.6 0.6
High blood pressure (siblings) 3.2 4.6 11.8 2.2 1.3 -3.4 -0.3
Forced vital capacity (FVC), Best measure 1.4 5.2 9.7 3.1 0.7 -2.5 -2.1
Body fat percentage 2.1 8.4 21.0 -2.9 -1.3 1.7 4.6
Leg fat percentage (right) 2.1 7.7 23.6 -2.4 -0.6 1.1 4.9
Arm fat-free mass (right) 6.2 32.0 63.7 6.2 2.8 -8.0 -4.2
Exposure to tobacco smoke outside home 0.4 0.6 1.1 0.3 0.9 -1.1 -0.6
Comparative body size at age 10 0.8 2.3 5.6 -2.4 -1.8 0.7 0.4
Number of full brothers 1.5 1.8 3.9 -1.6 -2.0 0.8 -0.0
Worry too long after embarrassment 1.0 1.7 3.9 1.0 0.3 -1.3 -2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 2.9 3.8 4.3 -2.1 -1.8 2.1 -1.9
Wheeze or whistling in the chest in last year 1.5 2.7 5.3 -2.3 -1.4 1.3 1.4
Number of children fathered 0.3 0.3 0.6 -0.8 -0.7 0.5 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.3 0.4 -0.5 -0.0 0.1
Age at first live birth 0.1 0.1 0.2 -0.4 -0.3 0.4 0.4
Pulse wave peak to peak time 1.5 1.8 2.6 1.3 0.7 -1.6 -1.6
Health satisfaction 0.2 0.2 0.3 -0.6 -0.4 -0.4 -0.5
Shortness of breath walking on level ground 0.5 0.6 1.3 -0.1 -1.1 -0.5 0.8
Qualifications: College or University degree 0.2 0.8 2.4 0.5 0.4 0.5 -1.5
Eye problems/disorders: None of the above 1.7 2.0 3.8 -1.5 -0.7 1.2 2.0
Mouth/teeth dental problems: Loose teeth 1.0 1.2 1.9 -1.4 -1.1 1.0 0.7
Emphysema/chronic bronchitis 0.6 0.7 1.5 -1.2 -0.9 0.4 -0.3
Medication for pain relief, constipation, heartburn 0.1 0.2 0.4 0.7 0.5 0.2 0.2
Neck or shoulder pain in last month 0.3 0.4 1.1 -1.1 -0.7 -0.3 -0.2
Medication: Blood pressure 0.4 0.7 1.6 -0.1 0.1 -1.2 -1.0
Angina (self-reported) 1.4 1.9 5.9 0.1 -0.3 -1.2 -2.4
Migraine (self-reported) 0.4 0.5 1.2 -0.7 -1.1 0.5 0.4
Medication: Ibuprofen 0.3 0.4 1.3 0.2 0.1 1.1 0.3
Medication: Allopurinol 1.0 1.3 2.8 -0.6 -1.5 -0.2 -1.7
Medication: Omeprazole 0.9 1.1 2.5 1.0 0.7 -1.6 0.3
Medication: Seretide 50 evohaler 0.4 0.4 1.0 -1.0 -0.6 0.4 -0.5
Mean time to correctly identify matches 0.5 0.9 1.7 -1.3 -0.9 1.0 0.1
Heart disease (mother) 0.6 0.7 1.9 -0.7 -1.4 -0.0 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 2.0 0.6 1.4 -0.7 1.0
Whole body fat mass 0.5 2.2 5.8 0.2 0.4 -1.7 2.4
Leg fat mass (right) 0.6 2.3 6.7 -0.0 0.4 -1.6 2.6
Arm predicted mass (right) 5.7 29.1 57.5 5.9 2.7 -7.6 -4.1
Pulse rate, automated reading 1.6 5.1 12.5 -3.5 -1.5 2.2 0.9
Alcohol intake frequency. 0.3 0.7 1.6 0.6 0.7 -1.3 -0.2
Comparative height size at age 10 2.4 13.3 22.3 4.0 1.1 -4.7 -3.7
Number of full sisters 0.5 0.6 1.1 1.0 0.7 -0.8 -0.0
Suffer from ‘nerves’ 2.8 4.5 7.1 -2.4 -2.7 2.2 0.4
Overall health rating 0.8 1.7 3.5 -1.9 -1.7 0.1 -0.3
Chest pain or discomfort 0.3 0.5 1.0 -0.9 -0.2 -0.2 -1.0
Had major operations 0.5 0.6 2.0 -0.1 0.4 -0.3 -1.4
Age at last live birth 1.1 1.7 2.9 -1.2 -0.1 1.7 1.6
Family relationship satisfaction 0.9 1.1 1.3 -0.9 -1.0 1.2 -1.0
Leg pain on walking 1.1 1.3 2.4 -1.4 -0.8 -0.7 1.5
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 2.5 -0.5 -1.6 0.5 -0.1
Commuting to job workplace: Car/motor vehicle 0.7 0.7 1.2 -0.2 -1.1 0.8 -1.1
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 2.9 1.7 1.7 -0.8 0.1
Medication: Aspirin 1.3 1.7 3.3 -0.4 -1.1 -1.4 -1.8
Supplements: Vitamin C 1.6 1.8 4.9 -1.2 -0.2 2.2 1.0
Knee pain experienced in last month 2.4 3.7 6.7 -2.6 -2.0 1.7 1.0
Hypertension (Self-reported) 1.0 2.8 6.9 1.2 0.4 -2.6 -1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.4 0.8 0.8 -0.4 1.2
Illnesses of father: Heart disease 0.0 0.1 0.1 -0.3 0.1 0.2 0.3
Illnesses of siblings: Diabetes 0.9 1.1 1.8 1.2 0.2 -1.4 -1.0
Smoking status: Previous 0.2 0.2 0.5 -0.1 -0.7 -0.4 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 3.0 6.2 10.3 3.0 1.5 -3.2 -1.8
Whole body fat-free mass 6.7 38.5 72.9 6.9 3.2 -8.5 -4.8
Leg fat-free mass (right) 4.8 25.5 49.6 5.4 2.3 -7.0 -4.2
Arm fat percentage (left) 1.4 5.5 14.7 -2.4 -0.8 1.0 3.8
Average weekly red wine intake 1.3 1.9 3.2 -1.6 -1.8 1.3 0.0
Handedness (chirality/laterality): Left-handed 0.1 0.2 0.6 0.1 0.1 -0.2 0.8
Mood swings 0.1 0.1 0.2 -0.4 -0.4 0.1 0.1
Loneliness, isolation 0.3 0.4 0.9 0.1 -0.1 -0.9 -0.9
Long-standing illness, disability or infirmity 0.1 0.2 0.5 0.0 -0.3 -0.4 -0.7
Ever had bowel cancer screening 1.4 1.6 2.9 1.7 1.2 -1.3 0.7
Diabetes diagnosed by doctor 4.9 8.1 14.6 2.5 1.8 -2.8 -3.8
Ever had stillbirth, spontaneous miscarriage or termination 1.9 2.0 4.3 -1.3 -2.1 1.2 -0.7
Friendships satisfaction 1.6 2.0 3.9 -0.6 -1.7 0.9 -2.0
Qualifications: nursing, teaching 0.4 0.6 0.9 0.9 0.9 0.7 -0.4
Commuting to job workplace: Walk 0.5 0.5 1.0 -0.8 0.0 0.7 1.0
Eye problems/disorders: Cataract 1.1 1.3 4.5 0.6 -0.2 -0.5 -2.1
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.5 0.8 0.8 -1.2 0.3
Medication for cholesterol 1.2 1.9 5.7 0.1 0.9 0.9 2.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.8 0.3 -0.1 -1.4 -0.2
Back pain experienced in last month 0.7 1.0 1.8 -0.3 0.6 -1.3 1.3
Mineral and other dietary supplements 0.3 0.5 1.0 0.5 0.5 -0.5 -1.0
Breast cancer (self-reported) 2.0 2.4 2.9 1.6 1.7 -1.5 1.4
Asthma (self-reported) 0.0 0.0 0.1 0.2 -0.1 -0.2 -0.0
Osteoporosis (self-reported) 0.4 0.4 0.9 0.8 0.2 -1.0 0.4
Osteoarthritis (self-reported) 2.6 3.4 7.4 -1.5 -1.1 1.6 2.7
Medication: Aspirin 1.1 1.4 2.4 -0.3 -0.9 -1.5 -1.6
Medication: Gliclazide 0.2 0.3 1.0 0.1 1.0 -0.2 0.2
Illnesses of father: None of the above (group 1) 0.5 0.7 2.3 0.5 1.5 -0.1 0.3
Smoking status: Current 0.4 0.7 1.4 -0.8 -0.1 -1.2 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 3.0 1.7 1.4 -0.6 1.3
Whole body water mass 7.1 40.2 76.0 7.0 3.3 -8.7 -5.0
Leg predicted mass (right) 4.7 25.1 48.7 5.4 2.2 -7.0 -4.2
Arm fat mass (left) 0.5 2.2 5.2 0.6 0.8 -2.3 1.6
Number of self-reported non-cancer illnesses 1.1 1.9 3.5 1.3 0.0 -1.5 -1.9
Average weekly champagne plus white wine intake 0.9 1.3 3.0 -1.1 -0.8 1.7 0.4
Miserableness 0.4 0.7 2.1 -0.7 -0.4 1.4 -0.3
Guilty feelings 0.6 0.9 3.3 0.2 -0.5 0.0 -1.8
Wears glasses or contact lenses 0.5 0.6 1.3 0.4 -1.1 -0.6 -0.7
Ever taken oral contraceptive pill 0.5 0.5 0.9 0.2 -0.5 1.0 -0.9
Hearing aid user 1.3 1.5 5.6 -0.5 -0.2 0.5 2.4
Mother’s age at death 0.5 0.7 2.3 0.4 -0.4 -0.1 -1.5
Financial situation satisfaction 0.5 0.6 1.0 -0.5 -1.0 -0.6 -0.9
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.7 -0.3 -1.6 0.4 -0.8
Commuting to job workplace: Public transport 0.2 0.2 0.4 -0.3 -0.6 -0.2 -0.5
Eye problems/disorders: Glaucoma 1.0 1.2 1.6 1.3 1.2 -1.0 0.8
Medication: Blood pressure 1.1 2.0 4.4 0.5 -0.2 -1.8 -2.1
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.6 -0.0 0.2 -0.8 1.3
Supplements: Fish oil (including cod liver oil) 0.0 0.0 0.1 -0.0 -0.3 0.3 0.0
High cholesterol (Self-reported) 1.0 1.7 4.3 -0.8 -1.2 0.6 -2.1
Medication: Bendroflumethiazide 2.1 3.1 5.5 1.7 1.4 -2.4 -1.5
Medication: Paracetamol 2.3 3.5 4.9 -2.2 -1.6 1.6 2.0
Medication: Lisinopril 1.7 2.2 3.6 1.3 1.0 -1.6 -1.9
Medication: Atorvastatin 0.5 0.7 1.4 -1.0 -0.5 1.2 0.1
Illnesses of father: High blood pressure 0.4 0.4 1.1 0.1 -0.7 -0.4 -1.0
Alcohol drinker status: Never 2.9 3.5 6.1 2.0 2.5 -1.8 0.7
Ever smoked 0.8 1.4 4.0 0.7 0.2 -2.0 -1.0
Basal metabolic rate 5.6 30.9 62.3 6.1 3.0 -7.9 -3.9
Leg fat percentage (left) 2.0 7.1 20.7 -2.4 -0.8 1.1 4.6
Arm fat-free mass (left) 6.6 33.6 66.6 6.5 3.4 -8.2 -3.7
Number of operations (self-reported) 1.5 2.2 3.3 1.6 0.3 -1.8 -1.6
Average weekly beer plus cider intake 0.3 0.5 0.7 0.8 0.4 -0.6 -0.8
Irritability 0.4 0.6 1.7 0.3 0.7 -0.5 -1.3
Risk taking 0.3 0.4 0.8 -0.8 -0.9 0.3 -0.4
Ever had prostate specific antigen (PSA) test 2.5 2.9 5.4 2.3 0.6 -1.6 -1.8
Fractured/broken bones in last 5 years 1.8 2.3 4.5 -1.8 -0.6 2.1 1.2
Age started oral contraceptive pill 0.3 0.3 0.7 -0.4 -0.2 0.7 0.8
Diastolic blood pressure, automated reading 1.1 3.4 10.8 -1.5 -0.3 0.6 3.3
Ever depressed for a whole week 0.6 0.7 1.7 0.1 -1.0 -0.3 -1.3
Unable to work because of sickness or disability 1.3 1.7 3.5 -1.9 -1.2 1.4 0.2
Commuting to job workplace: Cycle 0.1 0.1 0.4 -0.3 -0.1 -0.1 0.6
Myopia 0.9 1.4 2.7 1.6 0.3 -1.4 -0.9
Vascular/heart problems diagnosed by doctor 1.0 2.8 6.8 -0.8 -0.1 2.6 2.0
Cholesterol lowering medication 0.5 0.8 2.8 0.1 0.3 -0.6 -1.7
Medication: Omeprazole (e.g. Zanprol) 1.6 1.9 3.8 1.3 1.1 -1.9 1.0
Pain experienced in last month 0.8 1.3 3.7 1.9 0.4 -0.5 -1.1
Supplements: Calcium 0.4 0.4 0.6 0.8 0.5 -0.7 0.5
Basal cell carcinoma (self-reported) 1.9 2.2 3.6 1.8 1.9 -1.4 0.2
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.0 -0.6 -1.1 -1.4 -1.2
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 3.4 -1.9 -1.6 0.8 -0.7
Heart disease (siblings) 0.6 0.8 1.9 -1.0 -1.4 0.3 -0.2
Alcohol drinker status: Previous 0.3 0.3 0.8 -0.0 0.7 0.1 0.9
Pack years of smoking 0.4 0.6 0.9 -0.9 -0.6 1.0 0.2
Impedance of whole body 5.9 30.1 54.3 -5.7 -3.0 7.4 4.9
Leg fat mass (left) 0.5 2.1 5.7 -0.1 0.3 -1.6 2.4
Arm predicted mass (left) 6.3 31.9 63.7 6.3 3.2 -8.0 -3.8