Best TWAS P=2.7e-39 · Best GWAS P=1.04e-36 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | GBAP1 | 0.04 | 0.03 | blup | 337 | 0.03 | 8.6e-05 | 1.7 | 6.1 | 9.2e-10 | 0.05 | 0.88 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RP11-307C12.11 | 0.09 | 0.02 | lasso | 3 | 0.02 | 1.2e-02 | -4.4 | 5.2 | 2.0e-07 | 0.25 | 0.33 | 0.03 | FALSE |
| 3 | GTEx | Artery Aorta | GBAP1 | 0.31 | 0.36 | enet | 22 | 0.39 | 1.0e-22 | 4.6 | 5.5 | 4.3e-08 | 0.05 | 1.00 | 0.00 | TRUE |
| 4 | GTEx | Brain Cerebellar Hemisphere | DCST2 | 0.45 | 0.10 | lasso | 6 | 0.16 | 6.6e-05 | -4.5 | 9.8 | 8.3e-23 | 0.75 | 0.01 | 0.96 | FALSE |
| 5 | GTEx | Brain Cerebellum | THBS3 | 0.17 | 0.15 | enet | 6 | 0.16 | 2.0e-05 | 4.1 | -5.7 | 1.3e-08 | -0.09 | 0.49 | 0.03 | FALSE |
| 6 | GTEx | Brain Nucleus accumbens basal ganglia | DCST2 | 0.28 | 0.04 | lasso | 5 | 0.13 | 2.0e-04 | 12.7 | 7.6 | 2.7e-14 | 0.69 | 0.02 | 0.90 | TRUE |
| 7 | GTEx | Brain Putamen basal ganglia | DCST2 | 0.56 | 0.05 | enet | 11 | 0.10 | 2.8e-03 | -4.5 | 5.4 | 6.4e-08 | 0.47 | 0.18 | 0.58 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Female) | FAM189B | 0.05 | -0.01 | lasso | 2 | 0.00 | 4.8e-01 | -6.6 | 6.6 | 3.9e-11 | 0.09 | 0.04 | 0.07 | FALSE |
| 9 | GTEx | Cells Transformed fibroblasts | SLC50A1 | 0.08 | 0.07 | lasso | 6 | 0.07 | 3.9e-06 | -4.1 | -5.7 | 1.4e-08 | -0.07 | 0.95 | 0.00 | FALSE |
| 10 | GTEx | Colon Sigmoid | GBAP1 | 0.16 | 0.13 | enet | 8 | 0.14 | 8.4e-06 | 4.5 | 5.8 | 5.3e-09 | 0.09 | 0.65 | 0.04 | FALSE |
| 11 | GTEx | Esophagus Gastroesophageal Junction | GBAP1 | 0.22 | 0.19 | enet | 6 | 0.17 | 6.8e-07 | 4.5 | 5.2 | 1.6e-07 | 0.08 | 0.90 | 0.01 | TRUE |
| 12 | GTEx | Esophagus Mucosa | ADAM15 | 0.11 | 0.02 | enet | 16 | 0.04 | 1.5e-03 | -5.9 | -5.7 | 1.2e-08 | -0.43 | 0.13 | 0.78 | FALSE |
| 13 | GTEx | Esophagus Mucosa | MUC1 | 0.17 | 0.20 | lasso | 4 | 0.18 | 5.6e-12 | -7.0 | -6.9 | 7.1e-12 | -0.12 | 1.00 | 0.00 | FALSE |
| 14 | GTEx | Pancreas | THBS3 | 0.36 | 0.14 | lasso | 6 | 0.12 | 1.0e-05 | 4.1 | -7.3 | 3.6e-13 | -0.34 | 0.18 | 0.54 | TRUE |
| 15 | GTEx | Pancreas | RP11-263K19.4 | 0.22 | 0.06 | enet | 23 | 0.05 | 3.1e-03 | 4.1 | -9.6 | 6.0e-22 | -0.43 | 0.06 | 0.49 | FALSE |
| 16 | GTEx | Skin Not Sun Exposed Suprapubic | GBAP1 | 0.15 | 0.06 | lasso | 4 | 0.06 | 3.6e-04 | -7.0 | 6.4 | 1.3e-10 | 0.11 | 0.54 | 0.04 | FALSE |
| 17 | GTEx | Skin Sun Exposed Lower leg | ADAM15 | 0.14 | 0.09 | lasso | 4 | 0.08 | 6.1e-07 | 12.7 | -13.1 | 2.7e-39 | -0.96 | 0.00 | 1.00 | TRUE |
| 18 | GTEx | Small Intestine Terminal Ileum | GBAP1 | 0.20 | 0.13 | lasso | 10 | 0.11 | 1.8e-03 | -4.1 | 5.3 | 1.3e-07 | 0.03 | 0.16 | 0.07 | FALSE |
| 19 | GTEx | Spleen | SHC1 | 0.22 | 0.14 | lasso | 2 | 0.08 | 4.0e-03 | -6.1 | -6.1 | 1.4e-09 | -0.15 | 0.14 | 0.05 | FALSE |
| 20 | GTEx | Spleen | GBAP1 | 0.33 | 0.23 | enet | 20 | 0.28 | 7.9e-08 | 4.5 | 5.3 | 1.3e-07 | 0.09 | 0.84 | 0.01 | FALSE |
| 21 | GTEx | Testis | MUC1 | 0.20 | 0.02 | lasso | 7 | 0.07 | 7.5e-04 | -7.0 | -6.1 | 9.2e-10 | -0.11 | 0.27 | 0.05 | FALSE |
| 22 | GTEx | Thyroid | DCST2 | 0.16 | 0.12 | lasso | 2 | 0.11 | 6.4e-09 | -4.5 | 6.5 | 7.8e-11 | 0.53 | 0.38 | 0.62 | FALSE |
| 23 | GTEx | Thyroid | MUC1 | 0.11 | 0.02 | enet | 15 | 0.09 | 1.5e-07 | 5.9 | 6.8 | 8.5e-12 | 0.13 | 0.98 | 0.00 | TRUE |
| 24 | GTEx | Vagina | GBAP1 | 0.27 | 0.08 | lasso | 7 | 0.17 | 1.3e-04 | -6.1 | 6.3 | 2.8e-10 | 0.09 | 0.25 | 0.05 | FALSE |
| 25 | METSIM | Adipose | DCST2 | 0.04 | 0.04 | enet | 12 | 0.04 | 4.3e-07 | -4.5 | 6.2 | 5.4e-10 | 0.47 | 0.86 | 0.11 | FALSE |
| 26 | NTR | Blood | ZBTB7B | 0.02 | 0.02 | lasso | 1 | 0.01 | 5.4e-05 | 7.3 | 7.3 | 3.8e-13 | 0.67 | 0.87 | 0.03 | FALSE |
| 27 | ROSMAP | Brain Pre-frontal Cortex | SLC50A1 | 0.06 | 0.02 | bslmm | 331 | 0.03 | 4.3e-05 | -7.0 | -7.9 | 3.4e-15 | -0.27 | 0.65 | 0.04 | FALSE |
| 28 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TRIM46 | 0.03 | 0.00 | blup | 33 | 0.02 | 3.6e-03 | -7.0 | -7.2 | 8.9e-13 | -0.11 | 0.01 | 0.66 | TRUE |
| 29 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LENEP | 0.01 | 0.00 | blup | 37 | 0.01 | 1.6e-03 | -4.2 | 6.6 | 3.9e-11 | 0.48 | 0.02 | 0.30 | FALSE |
| 30 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TRIM46 | 0.03 | 0.01 | blup | 32 | 0.01 | 4.9e-03 | -6.9 | -5.3 | 1.2e-07 | -0.11 | 0.00 | 0.53 | TRUE |
| 31 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | GBAP1 | 0.10 | 0.06 | enet | 9 | 0.04 | 5.1e-03 | 4.5 | 5.2 | 2.0e-07 | 0.02 | 0.02 | 0.35 | FALSE |
| 32 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DCST2 | 0.04 | 0.01 | blup | 50 | 0.03 | 2.0e-04 | -4.1 | -5.3 | 9.6e-08 | -0.37 | 0.22 | 0.10 | FALSE |
| 33 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MUC1 | 0.04 | 0.01 | enet | 4 | 0.02 | 1.3e-03 | -7.0 | -6.2 | 5.8e-10 | -0.15 | 0.00 | 0.84 | FALSE |
| 34 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RAG1AP1 | 0.07 | 0.00 | blup | 76 | 0.00 | 2.9e-01 | -2.7 | -5.8 | 7.2e-09 | -0.17 | 0.02 | 0.29 | FALSE |
| 35 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GBAP1 | 0.03 | 0.01 | blup | 26 | 0.02 | 1.9e-03 | -4.1 | 5.7 | 1.3e-08 | 0.07 | 0.04 | 0.82 | FALSE |
| 36 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RAG1AP1 | 0.07 | 0.05 | blup | 77 | 0.05 | 3.8e-06 | -6.8 | -5.5 | 4.3e-08 | -0.07 | 0.03 | 0.97 | FALSE |
| 37 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZBTB7B | 0.05 | 0.06 | lasso | 2 | 0.05 | 1.8e-06 | 12.7 | -12.6 | 1.2e-36 | -1.00 | 0.00 | 1.00 | FALSE |
| 38 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | GBAP1 | 0.05 | 0.04 | blup | 26 | 0.04 | 1.6e-03 | 4.5 | 5.3 | 1.1e-07 | 0.10 | 0.01 | 0.83 | FALSE |
| 39 | The Cancer Genome Atlas | Thyroid Carcinoma | GBAP1 | 0.02 | 0.01 | blup | 24 | 0.02 | 3.0e-03 | 4.5 | 5.2 | 1.8e-07 | 0.06 | 0.01 | 0.65 | FALSE |