[Hub]/) : Traits : Leg fat-free mass (left) :

chr1:154,238,383-155,910,830

Best TWAS P=2.7e-39 · Best GWAS P=1.04e-36 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex GBAP1 0.04 0.03 blup 337 0.03 8.6e-05 1.7 6.1 9.2e-10 0.05 0.88 0.00 FALSE
2 GTEx Adipose Subcutaneous RP11-307C12.11 0.09 0.02 lasso 3 0.02 1.2e-02 -4.4 5.2 2.0e-07 0.25 0.33 0.03 FALSE
3 GTEx Artery Aorta GBAP1 0.31 0.36 enet 22 0.39 1.0e-22 4.6 5.5 4.3e-08 0.05 1.00 0.00 TRUE
4 GTEx Brain Cerebellar Hemisphere DCST2 0.45 0.10 lasso 6 0.16 6.6e-05 -4.5 9.8 8.3e-23 0.75 0.01 0.96 FALSE
5 GTEx Brain Cerebellum THBS3 0.17 0.15 enet 6 0.16 2.0e-05 4.1 -5.7 1.3e-08 -0.09 0.49 0.03 FALSE
6 GTEx Brain Nucleus accumbens basal ganglia DCST2 0.28 0.04 lasso 5 0.13 2.0e-04 12.7 7.6 2.7e-14 0.69 0.02 0.90 TRUE
7 GTEx Brain Putamen basal ganglia DCST2 0.56 0.05 enet 11 0.10 2.8e-03 -4.5 5.4 6.4e-08 0.47 0.18 0.58 FALSE
8 GTEx Breast Mammary Tissue (Female) FAM189B 0.05 -0.01 lasso 2 0.00 4.8e-01 -6.6 6.6 3.9e-11 0.09 0.04 0.07 FALSE
9 GTEx Cells Transformed fibroblasts SLC50A1 0.08 0.07 lasso 6 0.07 3.9e-06 -4.1 -5.7 1.4e-08 -0.07 0.95 0.00 FALSE
10 GTEx Colon Sigmoid GBAP1 0.16 0.13 enet 8 0.14 8.4e-06 4.5 5.8 5.3e-09 0.09 0.65 0.04 FALSE
11 GTEx Esophagus Gastroesophageal Junction GBAP1 0.22 0.19 enet 6 0.17 6.8e-07 4.5 5.2 1.6e-07 0.08 0.90 0.01 TRUE
12 GTEx Esophagus Mucosa ADAM15 0.11 0.02 enet 16 0.04 1.5e-03 -5.9 -5.7 1.2e-08 -0.43 0.13 0.78 FALSE
13 GTEx Esophagus Mucosa MUC1 0.17 0.20 lasso 4 0.18 5.6e-12 -7.0 -6.9 7.1e-12 -0.12 1.00 0.00 FALSE
14 GTEx Pancreas THBS3 0.36 0.14 lasso 6 0.12 1.0e-05 4.1 -7.3 3.6e-13 -0.34 0.18 0.54 TRUE
15 GTEx Pancreas RP11-263K19.4 0.22 0.06 enet 23 0.05 3.1e-03 4.1 -9.6 6.0e-22 -0.43 0.06 0.49 FALSE
16 GTEx Skin Not Sun Exposed Suprapubic GBAP1 0.15 0.06 lasso 4 0.06 3.6e-04 -7.0 6.4 1.3e-10 0.11 0.54 0.04 FALSE
17 GTEx Skin Sun Exposed Lower leg ADAM15 0.14 0.09 lasso 4 0.08 6.1e-07 12.7 -13.1 2.7e-39 -0.96 0.00 1.00 TRUE
18 GTEx Small Intestine Terminal Ileum GBAP1 0.20 0.13 lasso 10 0.11 1.8e-03 -4.1 5.3 1.3e-07 0.03 0.16 0.07 FALSE
19 GTEx Spleen SHC1 0.22 0.14 lasso 2 0.08 4.0e-03 -6.1 -6.1 1.4e-09 -0.15 0.14 0.05 FALSE
20 GTEx Spleen GBAP1 0.33 0.23 enet 20 0.28 7.9e-08 4.5 5.3 1.3e-07 0.09 0.84 0.01 FALSE
21 GTEx Testis MUC1 0.20 0.02 lasso 7 0.07 7.5e-04 -7.0 -6.1 9.2e-10 -0.11 0.27 0.05 FALSE
22 GTEx Thyroid DCST2 0.16 0.12 lasso 2 0.11 6.4e-09 -4.5 6.5 7.8e-11 0.53 0.38 0.62 FALSE
23 GTEx Thyroid MUC1 0.11 0.02 enet 15 0.09 1.5e-07 5.9 6.8 8.5e-12 0.13 0.98 0.00 TRUE
24 GTEx Vagina GBAP1 0.27 0.08 lasso 7 0.17 1.3e-04 -6.1 6.3 2.8e-10 0.09 0.25 0.05 FALSE
25 METSIM Adipose DCST2 0.04 0.04 enet 12 0.04 4.3e-07 -4.5 6.2 5.4e-10 0.47 0.86 0.11 FALSE
26 NTR Blood ZBTB7B 0.02 0.02 lasso 1 0.01 5.4e-05 7.3 7.3 3.8e-13 0.67 0.87 0.03 FALSE
27 ROSMAP Brain Pre-frontal Cortex SLC50A1 0.06 0.02 bslmm 331 0.03 4.3e-05 -7.0 -7.9 3.4e-15 -0.27 0.65 0.04 FALSE
28 The Cancer Genome Atlas Bladder Urothelial Carcinoma TRIM46 0.03 0.00 blup 33 0.02 3.6e-03 -7.0 -7.2 8.9e-13 -0.11 0.01 0.66 TRUE
29 The Cancer Genome Atlas Breast Invasive Carcinoma LENEP 0.01 0.00 blup 37 0.01 1.6e-03 -4.2 6.6 3.9e-11 0.48 0.02 0.30 FALSE
30 The Cancer Genome Atlas Breast Invasive Carcinoma TRIM46 0.03 0.01 blup 32 0.01 4.9e-03 -6.9 -5.3 1.2e-07 -0.11 0.00 0.53 TRUE
31 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma GBAP1 0.10 0.06 enet 9 0.04 5.1e-03 4.5 5.2 2.0e-07 0.02 0.02 0.35 FALSE
32 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma DCST2 0.04 0.01 blup 50 0.03 2.0e-04 -4.1 -5.3 9.6e-08 -0.37 0.22 0.10 FALSE
33 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MUC1 0.04 0.01 enet 4 0.02 1.3e-03 -7.0 -6.2 5.8e-10 -0.15 0.00 0.84 FALSE
34 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma RAG1AP1 0.07 0.00 blup 76 0.00 2.9e-01 -2.7 -5.8 7.2e-09 -0.17 0.02 0.29 FALSE
35 The Cancer Genome Atlas Brain Lower Grade Glioma GBAP1 0.03 0.01 blup 26 0.02 1.9e-03 -4.1 5.7 1.3e-08 0.07 0.04 0.82 FALSE
36 The Cancer Genome Atlas Brain Lower Grade Glioma RAG1AP1 0.07 0.05 blup 77 0.05 3.8e-06 -6.8 -5.5 4.3e-08 -0.07 0.03 0.97 FALSE
37 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ZBTB7B 0.05 0.06 lasso 2 0.05 1.8e-06 12.7 -12.6 1.2e-36 -1.00 0.00 1.00 FALSE
38 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma GBAP1 0.05 0.04 blup 26 0.04 1.6e-03 4.5 5.3 1.1e-07 0.10 0.01 0.83 FALSE
39 The Cancer Genome Atlas Thyroid Carcinoma GBAP1 0.02 0.01 blup 24 0.02 3.0e-03 4.5 5.2 1.8e-07 0.06 0.01 0.65 FALSE