[Hub]/) : Traits : Arm fat mass (right) :

chr7:73,425,238-78,122,616

Best TWAS P=8.45e-19 · Best GWAS P=1.93e-17 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex DTX2P1-UPK3BP1-PMS2P11 0.18 0.09 enet 21 0.12 6.1e-15 6.0 7.4 1.0e-13 -0.10 0.00 1.00 TRUE
2 CommonMind Brain Pre-frontal Cortex POM121C 0.08 0.05 lasso 2 0.04 1.1e-05 -8.5 -8.3 1.4e-16 0.99 0.00 1.00 FALSE
3 CommonMind Brain Pre-frontal Cortex RSBN1L 0.09 0.09 enet 9 0.09 2.0e-11 -5.0 -5.2 2.0e-07 0.04 0.14 0.86 FALSE
4 CommonMind Brain Pre-frontal Cortex STAG3L1 0.23 0.14 enet 13 0.17 1.0e-19 -8.5 -7.7 1.1e-14 0.91 0.00 1.00 FALSE
5 GTEx Adipose Subcutaneous PMS2P3 0.15 0.12 lasso 3 0.10 9.8e-09 -7.5 -7.8 8.1e-15 0.96 0.00 1.00 FALSE
6 GTEx Adipose Subcutaneous TMEM60 0.08 0.05 lasso 4 0.05 7.3e-05 -5.3 -5.1 3.1e-07 0.01 0.10 0.90 FALSE
7 GTEx Adipose Subcutaneous POM121C 0.20 0.11 enet 18 0.12 1.2e-09 -8.5 -7.0 1.8e-12 0.80 0.00 1.00 FALSE
8 GTEx Adipose Subcutaneous TRIM73 0.20 0.12 enet 26 0.12 2.0e-10 -8.5 -7.1 1.5e-12 0.82 0.00 1.00 FALSE
9 GTEx Adipose Subcutaneous STAG3L1 0.30 0.24 enet 24 0.27 2.4e-22 -8.5 -8.2 2.6e-16 0.92 0.00 1.00 FALSE
10 GTEx Adipose Visceral Omentum POM121C 0.16 0.10 lasso 5 0.12 7.2e-07 5.2 -6.7 2.5e-11 0.80 0.02 0.98 FALSE
11 GTEx Adipose Visceral Omentum TRIM73 0.17 0.19 lasso 3 0.22 1.4e-11 -7.5 -6.6 3.4e-11 0.92 0.00 1.00 FALSE
12 GTEx Adipose Visceral Omentum STAG3L1 0.20 0.19 lasso 3 0.17 2.3e-09 -8.5 -8.4 3.8e-17 1.00 0.00 1.00 FALSE
13 GTEx Artery Aorta GSAP 0.19 0.07 lasso 2 0.04 2.8e-03 5.4 -5.9 3.1e-09 -0.01 0.21 0.25 TRUE
14 GTEx Artery Aorta STAG3L1 0.18 0.03 lasso 4 0.08 3.9e-05 -8.5 -8.3 1.2e-16 1.00 0.00 1.00 FALSE
15 GTEx Artery Coronary PMS2P5 0.15 -0.01 enet 13 0.08 1.4e-03 4.3 -5.4 5.8e-08 0.20 0.01 0.68 FALSE
16 GTEx Artery Coronary STAG3L1 0.28 0.13 lasso 4 0.17 1.8e-06 -7.7 -7.8 4.7e-15 0.86 0.01 0.99 FALSE
17 GTEx Artery Tibial PMS2P5 0.21 0.08 lasso 5 0.07 1.9e-06 4.3 -5.2 2.2e-07 0.17 0.07 0.84 FALSE
18 GTEx Artery Tibial POM121C 0.12 0.10 lasso 1 0.10 6.8e-08 -8.5 -8.5 1.9e-17 1.00 0.00 1.00 FALSE
19 GTEx Artery Tibial TRIM73 0.10 0.00 lasso 7 0.02 5.5e-03 -8.5 -5.7 1.2e-08 0.82 0.00 0.96 FALSE
20 GTEx Artery Tibial STAG3L1 0.25 0.19 lasso 4 0.19 8.3e-15 -8.5 -8.5 1.5e-17 1.00 0.00 1.00 FALSE
21 GTEx Artery Tibial FAM185BP 0.11 0.02 enet 22 0.02 1.1e-02 5.5 6.1 1.4e-09 -0.04 0.06 0.46 FALSE
22 GTEx Brain Cerebellar Hemisphere POM121C 0.33 0.32 lasso 3 0.30 1.4e-08 -8.5 -8.4 5.1e-17 1.00 0.00 1.00 FALSE
23 GTEx Brain Cerebellar Hemisphere TRIM73 0.35 0.28 enet 25 0.25 3.6e-07 -8.5 -6.5 7.3e-11 0.84 0.00 1.00 FALSE
24 GTEx Brain Cerebellum POM121C 0.30 0.15 lasso 8 0.08 2.4e-03 -8.5 -7.6 3.3e-14 0.90 0.00 0.97 FALSE
25 GTEx Brain Cerebellum TRIM73 0.24 0.06 enet 12 0.14 8.2e-05 -7.5 -5.4 6.3e-08 0.83 0.00 0.98 FALSE
26 GTEx Brain Cerebellum GSAP 0.38 0.30 lasso 4 0.31 6.4e-10 5.5 -5.6 2.5e-08 -0.03 0.40 0.56 FALSE
27 GTEx Brain Cerebellum RSBN1L 0.14 0.12 lasso 2 0.13 1.3e-04 5.1 5.2 2.0e-07 0.00 0.06 0.88 FALSE
28 GTEx Brain Frontal Cortex BA9 POM121C 0.43 0.16 enet 24 0.17 3.4e-05 -8.5 -6.1 9.2e-10 0.81 0.00 0.98 FALSE
29 GTEx Brain Frontal Cortex BA9 GSAP 0.38 0.22 lasso 6 0.21 3.0e-06 5.5 -6.1 1.1e-09 -0.01 0.12 0.32 TRUE
30 GTEx Brain Hippocampus PMS2P5 0.37 0.03 enet 12 0.05 2.9e-02 4.7 -5.5 2.9e-08 0.13 0.01 0.45 FALSE
31 GTEx Brain Nucleus accumbens basal ganglia PMS2P5 0.27 0.00 enet 20 0.03 6.6e-02 4.3 -5.3 1.3e-07 0.18 0.02 0.30 FALSE
32 GTEx Brain Nucleus accumbens basal ganglia POM121C 0.33 0.27 enet 11 0.25 2.7e-07 5.2 -5.5 3.7e-08 0.59 0.04 0.86 FALSE
33 GTEx Brain Nucleus accumbens basal ganglia TRIM73 0.34 0.16 enet 11 0.29 1.5e-08 5.2 -7.0 2.6e-12 0.82 0.00 1.00 FALSE
34 GTEx Brain Nucleus accumbens basal ganglia STAG3L1 0.29 0.09 enet 13 0.18 1.9e-05 -8.5 -7.0 2.1e-12 0.79 0.00 0.97 FALSE
35 GTEx Brain Putamen basal ganglia PMS2P3 0.37 0.13 lasso 6 0.18 6.0e-05 -7.7 -6.8 1.5e-11 0.73 0.01 0.85 FALSE
36 GTEx Breast Mammary Tissue PMS2P3 0.19 0.14 lasso 4 0.19 3.5e-10 -7.5 -7.5 8.5e-14 0.88 0.00 1.00 FALSE
37 GTEx Breast Mammary Tissue STAG3L1 0.16 0.15 lasso 2 0.14 8.7e-08 -8.5 -8.5 2.3e-17 0.98 0.00 1.00 FALSE
38 GTEx Breast Mammary Tissue (Female) PMS2P3 0.31 0.05 enet 8 0.10 6.2e-04 -7.7 -6.0 2.2e-09 0.69 0.02 0.79 FALSE
39 GTEx Breast Mammary Tissue (Female) POM121C 0.17 -0.01 lasso 3 0.02 6.3e-02 -8.5 -7.8 5.4e-15 0.90 0.01 0.63 TRUE
40 GTEx Breast Mammary Tissue (Female) STAG3L1 0.04 0.12 lasso 1 0.04 2.9e-02 -8.5 -8.5 1.9e-17 1.00 0.00 0.96 FALSE
41 GTEx Cells EBV-transformed lymphocytes STAG3L1 0.43 0.21 enet 21 0.23 3.8e-08 -8.5 -8.0 1.2e-15 0.86 0.00 1.00 FALSE
42 GTEx Cells Transformed fibroblasts PMS2P5 0.31 0.16 lasso 5 0.18 2.1e-13 4.3 -5.2 2.2e-07 0.15 0.23 0.72 FALSE
43 GTEx Cells Transformed fibroblasts PMS2P3 0.23 0.15 lasso 6 0.15 1.4e-11 -7.5 -7.7 1.0e-14 0.94 0.00 1.00 FALSE
44 GTEx Cells Transformed fibroblasts TMEM60 0.25 0.20 lasso 4 0.20 1.5e-14 -5.4 -5.4 5.5e-08 0.02 0.04 0.96 FALSE
45 GTEx Cells Transformed fibroblasts POM121C 0.15 0.06 lasso 5 0.07 1.2e-05 -8.5 -8.6 1.1e-17 0.99 0.00 1.00 FALSE
46 GTEx Cells Transformed fibroblasts STAG3L1 0.22 0.17 lasso 4 0.18 2.6e-13 -8.5 -8.5 1.9e-17 0.96 0.00 1.00 FALSE
47 GTEx Colon Sigmoid STAG3L1 0.30 0.18 lasso 4 0.18 8.5e-07 -8.5 -8.2 3.8e-16 0.97 0.00 1.00 FALSE
48 GTEx Colon Transverse STAG3L1 0.22 0.18 lasso 1 0.16 4.0e-08 -8.5 -8.5 1.9e-17 1.00 0.00 1.00 FALSE
49 GTEx Esophagus Gastroesophageal Junction STAG3L1 0.36 0.16 lasso 5 0.16 1.7e-06 -8.5 -7.8 8.2e-15 0.93 0.00 1.00 FALSE
50 GTEx Esophagus Gastroesophageal Junction RSBN1L-AS1 0.38 0.41 lasso 12 0.44 1.2e-17 -5.4 -5.2 2.0e-07 0.02 0.08 0.92 FALSE
51 GTEx Esophagus Mucosa PMS2P3 0.14 0.15 lasso 2 0.14 9.7e-10 -8.5 -8.7 4.7e-18 1.00 0.00 1.00 FALSE
52 GTEx Esophagus Mucosa TMEM60 0.06 0.04 lasso 2 0.04 1.0e-03 -5.4 -5.4 7.9e-08 0.02 0.05 0.94 FALSE
53 GTEx Esophagus Mucosa POM121C 0.13 0.10 lasso 1 0.07 1.0e-05 -8.5 -8.5 1.9e-17 1.00 0.00 1.00 FALSE
54 GTEx Esophagus Mucosa STAG3L1 0.19 0.19 lasso 1 0.18 2.4e-12 -8.5 -8.5 1.9e-17 1.00 0.00 1.00 FALSE
55 GTEx Esophagus Muscularis STAG3L2 0.23 0.09 enet 33 0.15 1.9e-09 4.3 -5.4 6.9e-08 0.26 0.02 0.97 FALSE
56 GTEx Esophagus Muscularis TRIM73 0.12 0.07 lasso 2 0.05 3.5e-04 -7.5 -7.5 7.8e-14 0.96 0.00 0.98 FALSE
57 GTEx Esophagus Muscularis STAG3L1 0.30 0.15 lasso 4 0.16 4.3e-10 -8.5 -7.8 4.8e-15 0.94 0.00 1.00 FALSE
58 GTEx Heart Atrial Appendage STAG3L1 0.14 0.04 enet 12 0.04 5.0e-03 -7.5 -7.1 1.2e-12 0.76 0.00 0.95 FALSE
59 GTEx Heart Left Ventricle POM121C 0.13 0.12 lasso 1 0.09 2.2e-05 -8.5 -8.5 1.9e-17 1.00 0.00 1.00 FALSE
60 GTEx Lung POM121C 0.13 0.10 lasso 3 0.10 7.8e-08 -8.5 -8.6 1.2e-17 0.98 0.00 1.00 FALSE
61 GTEx Lung TRIM73 0.14 0.03 enet 8 0.06 2.9e-05 -7.5 -6.5 8.4e-11 0.79 0.00 0.99 FALSE
62 GTEx Lung STAG3L1 0.28 0.12 enet 35 0.16 3.3e-12 -8.5 -7.4 1.3e-13 0.79 0.00 1.00 FALSE
63 GTEx Muscle Skeletal PMS2P3 0.07 0.07 lasso 2 0.06 3.8e-06 -8.5 -8.5 2.3e-17 1.00 0.00 1.00 FALSE
64 GTEx Muscle Skeletal TMEM60 0.11 0.12 lasso 4 0.12 4.6e-12 -5.4 5.6 2.0e-08 -0.03 0.05 0.95 FALSE
65 GTEx Muscle Skeletal TRIM73 0.08 0.05 enet 11 0.06 3.4e-06 -8.5 -8.1 7.4e-16 0.88 0.00 1.00 FALSE
66 GTEx Muscle Skeletal GSAP 0.20 0.12 lasso 2 0.12 1.8e-11 5.5 -5.5 3.6e-08 -0.01 0.35 0.65 FALSE
67 GTEx Muscle Skeletal STAG3L1 0.16 0.10 enet 24 0.10 3.7e-10 -8.5 -7.0 2.1e-12 0.85 0.00 1.00 FALSE
68 GTEx Nerve Tibial PMS2P5 0.16 0.04 enet 34 0.08 3.5e-06 4.3 -5.7 1.4e-08 0.22 0.02 0.96 TRUE
69 GTEx Nerve Tibial PMS2P3 0.29 0.13 enet 4 0.18 1.1e-12 -7.7 -7.3 2.8e-13 0.87 0.03 0.97 FALSE
70 GTEx Nerve Tibial TMEM60 0.14 0.14 lasso 8 0.12 1.1e-08 -5.4 -5.4 5.4e-08 0.02 0.07 0.93 FALSE
71 GTEx Nerve Tibial POM121C 0.22 0.14 lasso 5 0.14 6.9e-10 -8.5 -8.4 4.2e-17 0.97 0.00 1.00 FALSE
72 GTEx Nerve Tibial STAG3L2 0.36 0.09 enet 13 0.24 9.5e-17 4.3 -6.0 2.6e-09 0.25 0.03 0.96 FALSE
73 GTEx Nerve Tibial TRIM73 0.19 0.20 enet 6 0.20 6.3e-14 -8.5 -7.4 1.0e-13 0.96 0.00 1.00 FALSE
74 GTEx Nerve Tibial STAG3L1 0.37 0.21 enet 34 0.22 1.2e-15 -8.5 -6.3 2.9e-10 0.83 0.00 1.00 TRUE
75 GTEx Ovary RHBDD2 0.55 0.00 enet 24 0.07 7.6e-03 -7.7 5.4 6.7e-08 -0.56 0.03 0.29 FALSE
76 GTEx Ovary GSAP 0.27 -0.01 lasso 7 0.02 1.3e-01 5.5 -5.2 2.0e-07 -0.01 0.05 0.13 FALSE
77 GTEx Pituitary TMEM60 0.19 0.06 lasso 6 0.04 2.8e-02 4.9 -5.4 6.7e-08 0.02 0.06 0.84 FALSE
78 GTEx Skin Not Sun Exposed Suprapubic PMS2P3 0.26 0.19 lasso 3 0.17 1.3e-09 -8.5 -8.4 4.3e-17 0.99 0.00 1.00 FALSE
79 GTEx Skin Not Sun Exposed Suprapubic STAG3L1 0.13 0.19 lasso 1 0.18 2.6e-10 -8.5 -8.5 1.9e-17 1.00 0.00 1.00 FALSE
80 GTEx Skin Sun Exposed Lower leg PMS2P3 0.38 0.30 lasso 3 0.29 1.9e-24 -8.5 -8.6 1.2e-17 1.00 0.00 1.00 FALSE
81 GTEx Skin Sun Exposed Lower leg TMEM60 0.10 0.10 lasso 3 0.09 1.4e-07 -5.4 -5.4 5.4e-08 0.03 0.04 0.96 FALSE
82 GTEx Skin Sun Exposed Lower leg STAG3L2 0.15 0.05 enet 8 0.08 2.8e-07 4.3 -5.7 1.3e-08 0.24 0.14 0.62 TRUE
83 GTEx Skin Sun Exposed Lower leg TRIM73 0.13 0.08 enet 10 0.14 1.6e-11 -7.5 -6.0 1.8e-09 0.85 0.01 0.99 FALSE
84 GTEx Skin Sun Exposed Lower leg STAG3L1 0.27 0.15 lasso 5 0.15 1.3e-12 -8.5 -8.6 1.2e-17 0.98 0.00 1.00 FALSE
85 GTEx Stomach PMS2P3 0.16 0.07 lasso 5 0.09 3.7e-05 -7.7 -7.9 3.6e-15 0.91 0.00 0.99 FALSE
86 GTEx Stomach TRIM73 0.23 0.09 lasso 5 0.09 3.2e-05 -8.5 -8.1 4.9e-16 0.96 0.00 0.99 FALSE
87 GTEx Stomach STAG3L1 0.35 0.20 lasso 5 0.18 4.2e-09 -7.7 -7.8 9.2e-15 0.86 0.01 0.99 FALSE
88 GTEx Testis TRIM73 0.20 0.21 lasso 2 0.19 6.2e-09 -8.5 -8.4 3.4e-17 1.00 0.00 1.00 FALSE
89 GTEx Testis STAG3L1 0.24 0.24 enet 14 0.27 1.4e-12 -8.5 -7.8 8.6e-15 0.88 0.00 1.00 FALSE
90 GTEx Thyroid POM121C 0.14 0.08 lasso 3 0.07 3.4e-06 -8.5 -8.3 1.0e-16 0.96 0.00 1.00 FALSE
91 GTEx Thyroid GTF2IRD2B 0.03 0.04 lasso 1 0.03 1.9e-03 5.1 5.1 3.1e-07 -0.17 0.01 0.84 FALSE
92 GTEx Thyroid TRIM73 0.21 0.17 lasso 4 0.18 1.6e-13 -8.5 -7.6 2.8e-14 0.97 0.00 1.00 FALSE
93 GTEx Thyroid GSAP 0.19 0.08 lasso 3 0.07 3.3e-06 5.4 -5.3 1.1e-07 -0.03 0.42 0.53 FALSE
94 GTEx Thyroid STAG3L1 0.36 0.24 enet 17 0.27 8.0e-21 -8.5 -7.9 3.4e-15 0.92 0.00 1.00 FALSE
95 GTEx Whole Blood TMEM60 0.05 0.04 enet 7 0.03 5.4e-04 -5.0 -5.1 3.0e-07 0.03 0.09 0.90 FALSE
96 GTEx Whole Blood STAG3L1 0.08 0.06 lasso 3 0.07 2.8e-07 -8.5 -8.5 2.1e-17 1.00 0.00 1.00 FALSE
97 METSIM Adipose NCF1 0.05 0.03 blup 130 0.04 3.9e-07 4.9 5.9 3.4e-09 -0.22 0.02 0.98 FALSE
98 METSIM Adipose POM121C 0.11 0.08 lasso 1 0.08 1.6e-11 -8.5 -8.5 1.9e-17 1.00 0.00 1.00 FALSE
99 METSIM Adipose TMEM60 0.10 0.07 enet 9 0.08 2.1e-12 5.5 -5.5 4.5e-08 0.00 0.02 0.98 FALSE
100 METSIM Adipose TRIM73 0.11 0.11 lasso 5 0.12 8.6e-18 -7.5 -7.4 1.8e-13 0.95 0.01 0.99 FALSE
101 ROSMAP Brain Pre-frontal Cortex PMS2P3 0.05 0.04 lasso 1 0.03 4.6e-05 -8.5 -8.5 1.9e-17 1.00 0.00 1.00 FALSE
102 ROSMAP Brain Pre-frontal Cortex POM121C 0.36 0.26 lasso 7 0.27 2.8e-34 -8.5 -8.4 3.1e-17 0.99 0.00 1.00 FALSE
103 ROSMAP Brain Pre-frontal Cortex PMS2P2 0.17 0.08 enet 8 0.08 6.0e-10 -8.5 -7.7 1.1e-14 0.90 0.00 1.00 FALSE
104 ROSMAP Brain Pre-frontal Cortex GSAP 0.36 0.27 lasso 7 0.28 1.5e-35 5.5 -5.5 3.5e-08 -0.04 0.35 0.65 TRUE
105 ROSMAP Brain Pre-frontal Cortex RSBN1L 0.09 0.07 enet 42 0.08 9.9e-11 -4.7 -7.0 2.4e-12 0.04 0.16 0.84 TRUE
106 ROSMAP Brain Pre-frontal Cortex STAG3L1 0.46 0.32 lasso 4 0.32 2.2e-42 -8.5 -8.5 1.8e-17 1.00 0.00 1.00 FALSE
107 ROSMAP Brain Pre-frontal Cortex GTF2IP1 0.09 0.06 lasso 3 0.05 1.7e-07 -8.5 -8.5 1.8e-17 1.00 0.00 1.00 FALSE
108 The Cancer Genome Atlas Breast Invasive Carcinoma POM121C 0.04 0.04 lasso 2 0.03 1.2e-07 -8.5 -8.5 2.4e-17 1.00 0.00 1.00 FALSE
109 The Cancer Genome Atlas Breast Invasive Carcinoma TMEM60 0.02 0.02 lasso 1 0.02 2.3e-05 5.4 -5.4 6.1e-08 0.02 0.01 0.98 FALSE
110 The Cancer Genome Atlas Brain Lower Grade Glioma PION 0.08 0.05 lasso 3 0.05 8.5e-07 5.4 -5.1 3.0e-07 0.01 0.00 1.00 TRUE
111 The Cancer Genome Atlas Brain Lower Grade Glioma RSBN1L 0.02 0.02 blup 58 0.02 3.4e-03 -5.4 5.7 1.1e-08 -0.03 0.02 0.85 FALSE
112 The Cancer Genome Atlas Pancreatic Adenocarcinoma POM121C 0.07 0.02 enet 3 0.04 5.8e-03 -8.5 -6.8 8.5e-12 0.85 0.00 0.67 FALSE
113 The Cancer Genome Atlas Soft Tissue Sarcoma PHTF2 0.06 0.04 blup 72 0.04 2.0e-03 5.0 -5.4 6.0e-08 0.03 0.03 0.78 FALSE
114 The Cancer Genome Atlas Thyroid Carcinoma POM121C 0.08 0.07 lasso 3 0.07 3.6e-07 -8.5 -8.5 2.0e-17 0.99 0.00 1.00 FALSE
115 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma PMS2L3 0.23 0.14 lasso 2 0.14 1.3e-04 -8.5 -8.8 8.5e-19 0.98 0.00 0.92 TRUE