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chr19:46,923,752-51,224,297

Best TWAS P=1.87e-11 · Best GWAS P=1.92e-23 conditioned to 1.16e-09

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	METSIM	Adipose	SAE1	0.12	0.04	lasso	5	0.07	1.7e-10	-4.6	-6.7	1.9e-11	0.61	0.61	0.39	TRUE
10	GTEx	Testis	NTN5	0.16	0.02	enet	23	0.06	9.6e-04	-3.9	-6.4	1.8e-10	-0.02	0.03	0.77	TRUE
5	GTEx	Nerve Tibial	AP2A1	0.16	0.05	lasso	4	0.07	1.3e-05	-4.8	-6.0	1.8e-09	0.02	0.01	0.98	TRUE
18	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GRLF1	0.04	0.04	blup	51	0.03	7.0e-05	4.8	5.8	6.6e-09	-0.04	0.45	0.06	TRUE
7	GTEx	Skin Sun Exposed Lower leg	CCDC9	0.13	0.00	lasso	5	0.00	2.2e-01	2.6	-5.7	1.0e-08	0.23	0.11	0.21	TRUE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	LIN7B	0.02	0.00	enet	7	0.02	5.1e-05	4.7	-5.6	2.2e-08	-0.04	0.01	0.84	TRUE
2	GTEx	Cells EBV-transformed lymphocytes	SAE1	0.21	0.09	lasso	3	0.07	2.0e-03	-4.9	-6.5	1.1e-10	0.77	0.06	0.67	FALSE
12	YFS	Blood	SAE1	0.07	0.02	enet	18	0.05	3.6e-16	-8.1	-6.2	5.5e-10	0.56	0.99	0.01	FALSE
4	GTEx	Esophagus Mucosa	AP2A1	0.18	0.09	enet	8	0.13	7.7e-09	-4.5	-5.9	3.2e-09	-0.01	0.02	0.98	FALSE
6	GTEx	Skin Not Sun Exposed Suprapubic	RASIP1	0.15	0.04	lasso	6	0.08	2.9e-05	-5.0	-5.9	4.5e-09	0.03	0.31	0.49	FALSE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	SNRNP70	0.05	0.02	lasso	3	0.02	2.9e-02	4.8	-5.8	5.5e-09	-0.02	0.01	0.59	FALSE
8	GTEx	Skin Sun Exposed Lower leg	NTN5	0.11	0.09	enet	18	0.05	6.2e-05	-3.9	-5.5	3.4e-08	0.02	0.73	0.24	FALSE
17	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FUT2	0.10	0.01	blup	51	0.05	9.8e-04	-3.8	5.5	3.5e-08	-0.02	0.03	0.81	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	NTN5	0.02	0.01	enet	11	0.01	7.6e-04	-4.1	-5.4	5.6e-08	0.00	0.04	0.73	FALSE
13	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FUT2	0.05	0.01	blup	52	0.01	6.1e-02	-5.1	5.4	6.7e-08	0.01	0.02	0.53	FALSE
9	GTEx	Stomach	VRK3	0.10	-0.01	enet	10	-0.01	7.3e-01	3.3	5.4	7.2e-08	0.00	0.04	0.39	FALSE
3	GTEx	Cells Transformed fibroblasts	TBC1D17	0.11	0.03	enet	23	0.04	6.5e-04	-4.5	5.3	1.2e-07	-0.02	0.06	0.92	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FUT1	0.15	0.13	lasso	2	0.15	2.1e-17	5.4	-5.2	1.9e-07	-0.01	0.03	0.97	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	FUT1	0.04	0.03	lasso	3	0.03	2.7e-04	4.0	5.2	2.0e-07	0.01	0.03	0.81	FALSE