[Hub]/) : Traits : Arm fat mass (left) : ← →

chr12:121,194,565-125,270,773

Best TWAS P=5.78e-20 · Best GWAS P=5.92e-22 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Adipose Visceral Omentum	CCDC92	0.19	0.02	lasso	8	0.09	3.3e-05	6.1	9.1	5.8e-20	-0.12	0.03	0.96	TRUE
7	GTEx	Adipose Visceral Omentum	RP11-380L11.3	0.15	0.03	lasso	5	0.01	1.4e-01	6.2	8.9	5.3e-19	-0.08	0.02	0.90	TRUE
51	The Cancer Genome Atlas	Stomach Adenocarcinoma	MLXIP	0.06	0.02	blup	68	0.04	1.2e-03	7.3	8.3	7.9e-17	-0.23	0.02	0.88	TRUE
34	METSIM	Adipose	ABCB9	0.04	0.03	enet	19	0.03	7.7e-05	-6.1	-7.6	4.1e-14	0.38	0.08	0.65	TRUE
31	GTEx	Thyroid	CCDC92	0.06	0.03	lasso	3	0.02	1.1e-02	6.1	7.5	6.9e-14	-0.08	0.16	0.72	TRUE
12	GTEx	Cells Transformed fibroblasts	BCL7A	0.06	0.01	lasso	4	0.01	3.1e-02	4.3	-7.4	1.7e-13	0.24	0.09	0.05	TRUE
42	The Cancer Genome Atlas	Colon Adenocarcinoma	MLXIP	0.06	0.04	lasso	7	0.02	2.7e-02	7.3	7.2	4.4e-13	-0.17	0.02	0.94	TRUE
26	GTEx	Nerve Tibial	CCDC92	0.16	0.01	enet	6	0.04	6.7e-04	5.2	7.2	6.9e-13	-0.10	0.11	0.47	TRUE
14	GTEx	Colon Transverse	MLXIP	0.20	0.18	enet	23	0.14	5.8e-07	7.4	7.2	7.4e-13	-0.17	1.00	0.00	TRUE
15	GTEx	Colon Transverse	SNRNP35	0.18	0.02	lasso	8	0.04	6.5e-03	-4.0	6.7	1.7e-11	-0.16	0.06	0.32	TRUE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	VPS33A	0.01	0.02	lasso	2	0.02	2.7e-04	6.2	-6.2	5.2e-10	0.14	0.22	0.51	TRUE
3	GTEx	Adipose Subcutaneous	ZCCHC8	0.04	0.00	lasso	7	0.00	1.4e-01	5.7	6.2	5.9e-10	-0.31	0.17	0.10	TRUE
39	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LRRC43	0.06	0.03	enet	6	0.03	8.7e-04	-5.0	-6.0	2.0e-09	0.10	0.13	0.23	TRUE
38	YFS	Blood	PSMD9	0.04	0.03	bslmm	324	0.05	8.2e-15	-5.3	5.5	4.1e-08	-0.08	1.00	0.00	TRUE
29	GTEx	Skin Sun Exposed Lower leg	WDR66	0.19	0.10	lasso	5	0.08	5.5e-07	3.5	5.2	1.7e-07	-0.11	0.99	0.00	TRUE
33	GTEx	Whole Blood	DDX55	0.13	0.04	enet	13	0.06	3.3e-06	-3.3	5.2	2.5e-07	-0.17	0.34	0.02	TRUE
1	CommonMind	Brain Pre-frontal Cortex	CCDC62	0.12	0.06	enet	21	0.06	3.3e-08	4.0	-5.1	3.1e-07	0.13	0.99	0.00	TRUE
5	GTEx	Adipose Subcutaneous	RP11-380L11.3	0.09	0.03	lasso	3	0.03	1.4e-03	6.0	8.2	1.9e-16	-0.07	0.07	0.90	FALSE
4	GTEx	Adipose Subcutaneous	CCDC92	0.23	0.04	enet	27	0.16	6.9e-13	-5.3	8.1	4.3e-16	-0.09	0.02	0.98	FALSE
35	METSIM	Adipose	CCDC92	0.10	0.01	bslmm	435	0.06	5.5e-10	-3.1	7.7	1.1e-14	-0.08	0.01	0.99	FALSE
18	GTEx	Esophagus Mucosa	HIP1R	0.21	0.05	lasso	5	0.07	1.5e-05	4.0	7.5	4.4e-14	-0.21	0.47	0.26	FALSE
23	GTEx	Lung	CCDC92	0.14	0.00	enet	10	0.01	1.1e-01	6.9	7.1	1.6e-12	-0.08	0.00	0.97	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	VPS33A	0.06	0.00	enet	8	0.03	9.6e-04	5.7	-7.1	1.8e-12	0.20	0.06	0.93	FALSE
50	The Cancer Genome Atlas	Rectum Adenocarcinoma	MLXIP	0.18	0.14	lasso	4	0.13	5.1e-04	6.6	7.0	2.7e-12	-0.16	0.02	0.89	FALSE
37	METSIM	Adipose	RP11-214K3.24	0.05	0.03	bslmm	444	0.02	2.7e-04	5.3	6.9	4.8e-12	-0.07	0.19	0.68	FALSE
21	GTEx	Heart Atrial Appendage	RP11-380L11.4	0.18	0.11	lasso	7	0.12	6.5e-06	6.1	6.9	5.1e-12	-0.07	0.16	0.81	FALSE
16	GTEx	Esophagus Mucosa	KDM2B	0.11	0.04	enet	22	0.10	4.1e-07	3.0	6.8	1.2e-11	-0.10	0.92	0.01	FALSE
27	GTEx	Nerve Tibial	KNTC1	0.12	0.05	lasso	5	0.05	1.9e-04	-6.1	-6.8	1.2e-11	0.31	0.53	0.03	FALSE
22	GTEx	Heart Left Ventricle	CCDC92	0.26	0.19	lasso	4	0.21	1.9e-11	5.3	6.7	1.9e-11	-0.06	0.37	0.63	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	DNAH10	0.11	0.03	blup	99	0.05	8.2e-11	5.3	6.4	2.0e-10	-0.05	0.03	0.97	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF664	0.06	0.05	enet	9	0.05	2.8e-05	6.0	-6.3	2.3e-10	0.08	0.16	0.83	FALSE
25	GTEx	Muscle Skeletal	RSRC2	0.06	0.03	enet	7	0.04	9.6e-05	-3.0	-6.3	4.0e-10	0.43	0.25	0.48	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DNAH10	0.07	0.03	lasso	3	0.05	7.4e-06	6.2	6.2	6.3e-10	-0.06	0.03	0.97	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	VPS33A	0.04	0.05	lasso	1	0.04	3.0e-05	6.2	-6.2	7.0e-10	0.13	0.34	0.65	FALSE
13	GTEx	Colon Sigmoid	RP11-380L11.4	0.21	0.12	lasso	3	0.08	1.1e-03	6.0	6.1	8.8e-10	-0.06	0.15	0.62	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRC43	0.03	0.03	enet	8	0.02	1.5e-03	-4.7	-6.1	1.3e-09	0.15	0.10	0.07	FALSE
19	GTEx	Esophagus Muscularis	RP11-380L11.4	0.27	0.29	lasso	8	0.27	1.0e-16	6.1	6.0	1.5e-09	-0.05	0.18	0.82	FALSE
24	GTEx	Lung	RP11-380L11.4	0.07	0.07	lasso	3	0.07	8.2e-06	6.2	6.0	1.5e-09	-0.06	0.17	0.82	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	LRRC43	0.04	0.00	blup	58	0.01	6.9e-02	6.8	-6.0	1.7e-09	0.12	0.02	0.20	FALSE
11	GTEx	Breast Mammary Tissue (Female)	C12orf65	0.06	0.00	enet	13	-0.01	6.5e-01	-3.8	-6.0	2.7e-09	0.27	0.04	0.13	FALSE
10	GTEx	Breast Mammary Tissue (Male)	CCDC92	0.06	-0.01	lasso	3	0.00	4.3e-01	5.2	5.9	3.2e-09	-0.07	0.04	0.08	FALSE
20	GTEx	Heart Atrial Appendage	CCDC92	0.12	0.11	enet	9	0.11	1.1e-05	4.6	5.9	4.0e-09	-0.05	0.26	0.64	FALSE
30	GTEx	Testis	ABCB9	0.14	0.05	lasso	3	0.06	8.0e-04	6.7	-5.9	4.1e-09	0.22	0.25	0.05	FALSE
32	GTEx	Thyroid	ZNF664	0.13	0.06	lasso	11	0.08	6.7e-07	5.1	-5.9	4.5e-09	0.04	0.25	0.75	FALSE
8	GTEx	Artery Tibial	RP11-380L11.4	0.14	0.12	lasso	4	0.12	2.2e-09	6.0	5.9	4.8e-09	-0.04	0.21	0.79	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	VPS33A	0.03	0.05	lasso	1	0.05	4.4e-06	5.8	-5.8	4.9e-09	0.13	0.54	0.44	FALSE
36	METSIM	Adipose	MORN3	0.06	0.02	lasso	10	0.04	8.7e-07	5.0	5.8	6.3e-09	-0.05	0.95	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	HIP1R	0.06	0.02	lasso	6	0.04	1.9e-05	-6.1	-5.8	7.5e-09	0.09	0.18	0.02	FALSE
9	GTEx	Brain Putamen basal ganglia	WDR66	0.25	0.01	enet	16	-0.01	5.6e-01	6.8	-5.7	1.3e-08	0.15	0.06	0.26	FALSE
43	The Cancer Genome Atlas	Glioblastoma Multiforme	CCDC92	0.07	0.02	blup	52	0.04	1.8e-02	5.1	5.6	2.2e-08	-0.05	0.06	0.29	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	DNAH10	0.04	0.03	lasso	5	0.02	4.6e-03	5.2	5.6	2.4e-08	-0.05	0.02	0.82	FALSE
17	GTEx	Esophagus Mucosa	CCDC92	0.11	0.02	lasso	4	0.02	1.9e-02	5.3	5.5	4.3e-08	-0.05	0.28	0.39	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	GPR81	0.07	0.02	blup	54	0.02	4.4e-03	5.5	5.2	1.7e-07	-0.13	0.04	0.20	FALSE
28	GTEx	Prostate	CCDC92	0.31	0.10	enet	42	0.11	9.0e-04	5.1	5.2	2.5e-07	-0.08	0.14	0.36	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	PSMD9	0.09	0.10	lasso	4	0.10	7.4e-10	-5.2	5.1	2.9e-07	-0.02	0.01	0.99	FALSE