Hub : Genes

ZCCHC8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0400	0.0200	0.0037	0.000	NA	0.003	NA	0.004	0.3600	NA	0.1600	NA	0.140
2	GTEx	Artery Tibial	0.0649	0.0331	0.0054	0.023	NA	0.014	NA	0.010	0.0056	NA	0.0250	NA	0.054
3	GTEx	Testis	0.1340	0.0570	0.0026	0.006	NA	0.038	NA	0.026	0.1600	NA	0.0085	NA	0.024

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.1	1.7	5.2	2.3	0.3	0.0
Bipolar Disorder or Schizophrenia	3.8	9.2	25.4	5.0	1.1	-1.0
Depressed Affect (Nagel 2018)	2.8	5.9	9.6	-1.7	-3.1	2.3
Depression (Nagel 2018)	0.4	0.5	1.5	0.4	-1.2	0.0
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.3	1.8	0.2	0.3
Neuroticism (Nagel 2018)	3.0	7.0	13.1	-1.0	-3.6	2.6
Schizophrenia (2018)	4.0	8.3	21.7	4.7	1.2	-1.4
Schizophrenia vs Biploar Disorder	2.3	3.0	5.0	2.2	1.1	-1.7
Worry (Nagel 2018)	0.8	1.7	5.1	-0.2	-2.3	-0.1
Alzheimer’s Disease (in mother)	1.0	1.1	3.3	0.3	-0.2	-1.8
Alzheimer’s Disease (in father)	1.7	1.9	5.0	0.6	0.4	-2.2
Alzheimer’s Disease (including proxy)	3.3	4.7	11.2	0.4	1.7	-3.4
Crohns Disease (2017)	2.5	5.4	12.6	1.1	1.5	-3.6
Irritable Bowel Disease (IBD)	2.2	5.3	11.3	0.5	2.1	-3.4
Ulcerative Colitis (UC)	1.1	2.1	3.6	-0.2	1.7	-1.9
Major Depression (MDD)	0.3	0.4	0.7	-0.8	-0.4	0.5
Reaction Time	1.7	3.3	6.0	-2.4	-1.3	1.4
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.8	1.7	0.7	-0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	1.3	1.8	3.9	-2.0	-0.1	1.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	4.9	7.2	15.3	3.9	1.7	-1.8
Bipolar Disorder (2011)	3.2	3.1	4.4	2.1	0.7	-2.1
Body Mass Index (BMI) (2010)	2.5	3.4	7.4	2.7	0.9	-1.4
Coronary Artery Disease (CAD)	1.6	1.9	2.3	1.2	1.4	-1.5
Crohns Disease (2012)	2.5	4.0	9.7	-0.1	1.5	-3.1
Mean Putamen Volume	1.2	1.4	1.5	1.2	-1.2	1.1
Fasting Glucose	0.9	1.0	1.8	-1.3	-1.0	0.5
HbA1C	0.4	0.4	0.6	0.4	0.8	-0.7
HDL Cholesterol	0.8	1.3	3.4	0.0	-0.6	1.8
LDL Cholesterol	2.8	4.5	8.6	-1.0	-2.9	2.0
Lupus	1.5	2.3	4.4	-2.1	-0.8	1.4
Neuroticism (2016)	4.5	6.5	10.7	-1.4	-3.3	2.6
Primary Biliary Cirrhosis	1.3	1.9	4.5	2.1	-1.1	-0.2
Rheumatoid Arthritis	0.4	0.5	0.9	-0.9	0.0	0.9
Schizophrenia (2014)	3.9	8.7	23.4	4.8	1.3	-0.9
Triglycerides	0.2	0.3	0.5	-0.7	-0.6	0.1
Type 2 Diabetes (T2D) (2012)	1.4	1.7	4.3	-2.1	0.7	0.4
Ulcerative Colitis	2.2	3.2	6.1	-0.4	1.8	-2.5
Blood Eosinophil Count	1.7	13.2	28.5	-5.3	-1.9	2.7
Blood Platelet Count	0.6	6.8	19.4	-4.4	0.2	0.9
Blood Red Count	0.7	7.2	19.9	-4.5	1.3	0.2
Blood White Count	0.2	1.6	2.2	-0.8	-1.5	1.4
Heel T-Score	3.6	28.9	61.9	-7.9	-2.3	4.4
BMI	3.8	21.8	41.0	6.4	3.9	-3.0
Height	8.0	154.1	337.2	18.4	8.8	-6.9
Waist Hip Ratio (WHR)	2.5	11.2	30.0	-5.5	-0.3	-1.9
Systolic Blood Pressure	0.7	3.7	10.0	-3.2	-0.8	-0.7
Smoking Status	0.4	0.9	2.4	0.6	1.5	-0.2
Allergy or Eczema	0.4	1.0	2.0	-1.0	-1.4	-0.1
Cardiovascular Disease	0.8	2.7	6.6	-0.1	-2.6	1.2
Hypothyroidism (self reported)	1.5	3.5	9.5	3.1	-0.5	0.8
Respiratory disease	0.7	1.6	2.1	-1.3	-1.0	1.4
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.6	0.0	-0.8	1.2
Lung FEV1/FVC ratio	1.1	5.6	8.3	-2.9	-1.8	2.3
Lung FVC	1.2	6.0	9.1	-3.0	2.9	-0.9
Neuroticism	4.0	9.6	20.4	-1.3	-4.5	2.6
Chronotype (morning person)	1.1	2.6	4.5	-1.6	-1.0	2.1
Hair Pigment	0.1	1.5	3.7	-1.9	-0.7	-0.7
Tanning	0.2	2.1	4.0	2.0	1.4	0.3
Hand grip strength (left)	2.4	6.3	11.5	0.7	3.4	-2.6
Number of treatments/medications taken	1.2	2.2	4.9	-0.4	-1.2	2.2
Average weekly spirits intake	1.3	1.6	3.0	-1.7	-1.1	0.8
Sensitivity / hurt feelings	3.3	5.6	9.7	-0.5	-3.1	2.6
Frequency of depressed mood in last 2 weeks	1.4	2.0	5.7	-0.5	-2.4	0.2
Hearing difficulty/problems: Yes	0.2	0.3	0.5	0.7	-0.2	-0.6
Relative age of first facial hair	1.1	2.3	6.6	-2.6	-0.5	0.2
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	6.6	2.6	0.7	-1.0
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.4	1.6	1.1	-0.5
Ever had hysterectomy (womb removed)	1.5	1.7	2.0	-1.4	-1.3	1.1
Systolic blood pressure, automated reading	0.3	0.8	2.2	-1.5	0.3	-0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.6	-0.0	0.1	-0.8
Angina	0.9	1.2	1.8	0.6	-1.3	1.1
Medication for hormone replacement therapy	0.4	0.5	1.3	0.1	0.3	1.2
Vitamin and mineral supplements	0.3	0.4	0.6	0.2	-0.8	-0.8
Supplements: Zinc	0.8	0.8	1.0	1.0	0.6	-1.0
Medication: Co-codamol	1.2	1.4	2.7	0.4	1.6	-1.2
Medication: Metformin	1.3	1.8	2.6	-1.2	-1.2	1.6
Diabetes (father)	0.1	0.2	0.3	-0.5	0.3	-0.3
Diabetes (mother)	1.9	2.4	5.7	-0.5	-2.4	1.0
Severe depression (siblings)	0.9	1.0	1.6	1.2	-0.3	-1.3
Pack years adult smoking proportion	0.6	1.0	1.9	-0.1	1.4	-1.0
Impedance of leg (right)	1.4	6.9	16.8	-4.1	-2.0	0.1
Leg fat-free mass (left)	8.6	45.6	94.5	9.7	5.2	-3.8
Trunk fat percentage	1.9	7.6	18.3	4.3	1.5	-1.6
Hand grip strength (right)	2.2	5.9	10.6	1.1	3.3	-2.4
Townsend deprivation index at recruitment	3.4	4.8	7.8	-1.4	-2.8	2.2
Current tobacco smoking	0.3	0.5	0.9	-0.6	-0.4	1.0
Average weekly fortified wine intake	0.6	0.7	2.1	0.2	-1.4	0.2
Maternal smoking around birth	0.9	1.3	2.8	-0.1	1.7	-1.0
Fed-up feelings	1.9	3.4	5.3	-2.3	-1.4	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.3	-0.2	-1.5	0.7
Relative age voice broke	2.0	3.0	6.2	-2.5	1.1	-1.3
Taking other prescription medications	1.2	1.9	4.5	-0.6	-0.9	2.1
Age when periods started (menarche)	1.3	3.1	7.8	-2.8	-1.2	0.3
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.3	-1.5	-0.1	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	3.5	-1.5	-0.3	1.9
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	4.7	-0.1	-1.5	2.2
Qualifications: CSEs or equivalent	2.1	2.7	5.2	-2.3	-1.4	1.0
Serious illness, injury or assault to yourself	1.5	1.9	5.1	2.3	0.6	0.3
High blood pressure	2.6	7.3	8.0	-2.8	-2.6	2.6
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.4	-0.5	-0.7	-0.4
Multivitamins +/- minerals	0.6	0.8	1.7	0.5	0.6	1.3
Stomach or abdominal pain in last month	0.8	1.0	1.9	-0.9	-1.4	0.6
Supplements: Glucosamine	1.0	1.3	2.9	0.2	1.7	-1.0
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	-0.1	-1.3	0.4
Medication: Atenolol	0.5	0.6	1.7	0.3	-0.1	1.3
Medication: Levothyroxine sodium	2.2	3.8	5.3	1.5	-2.0	2.3
Sitting height	9.0	64.0	148.8	12.2	5.1	-4.2
Chronic bronchitis/emphysema (father)	1.9	2.2	4.0	-0.2	-1.6	2.0
High blood pressure (mother)	1.4	2.0	2.8	-1.4	-1.1	1.7
Body mass index (BMI)	1.3	5.4	13.4	3.7	1.6	-0.1
Impedance of leg (left)	2.0	9.9	23.5	-4.9	-2.5	0.3
Leg predicted mass (left)	8.6	45.5	94.8	9.7	5.2	-3.8
Trunk fat mass	4.6	19.9	44.2	6.6	3.0	-2.6
Waist circumference	2.0	7.3	13.1	3.6	2.3	-1.9
Number of incorrect matches in round	0.5	0.8	1.9	-0.2	-0.7	1.4
Past tobacco smoking	0.6	1.1	3.1	-1.8	-0.6	-0.0
Alcohol usually taken with meals	1.6	2.6	3.2	1.6	-1.4	1.8
Nervous feelings	2.5	4.6	11.9	0.5	-3.4	1.3
Frequency of tenseness / restlessness in last 2 weeks	3.4	5.3	6.1	-2.4	-2.5	2.0
Hearing difficulty/problems with background noise	0.3	0.5	0.6	0.8	-0.8	0.6
Hair/balding pattern: Pattern 2	0.6	0.8	1.1	-1.1	1.0	-0.3
Had menopause	2.0	2.5	6.3	2.5	1.1	0.2
Had other major operations	0.8	0.9	2.3	0.5	-1.5	-0.4
Forced vital capacity (FVC)	2.9	11.1	12.8	2.8	3.5	-3.6
Heel bone mineral density (BMD) T-score, automated (right)	2.7	6.1	9.4	-2.6	-1.5	3.1
Ever unenthusiastic/disinterested for a whole week	4.0	4.9	10.9	-0.8	-3.3	1.8
Qualifications: None of the above	5.9	12.7	32.5	-5.7	-1.7	1.7
Financial difficulties in last 2 years	0.7	1.0	2.4	-1.6	-0.3	0.7
Mouth/teeth dental problems	2.5	3.9	5.9	2.4	2.0	-1.3
Heart attack	0.4	0.5	0.7	0.8	-0.5	0.8
Allergy	0.5	1.2	2.7	1.6	0.8	-0.4
Pain all over the body in last month	3.6	3.9	4.7	1.7	2.2	-2.0
Diabetes (self-reported)	0.6	0.9	1.9	0.2	-0.9	1.4
Hayfever/allergic rhinitis (self-reported)	3.0	4.0	4.9	-2.2	-1.9	1.9
Medication: Ramipril	0.3	0.4	0.8	0.2	-0.9	0.6
Medication: Simvastatin	1.7	2.5	3.9	0.4	-2.0	1.8
Fluid intelligence score	1.5	3.1	7.2	2.7	1.4	-0.5
Illnesses of siblings	0.6	0.9	1.5	-0.6	0.8	-1.2
Neuroticism score	4.0	8.4	16.4	-1.3	-4.1	2.7
Weight	7.2	35.6	78.8	8.9	4.4	-3.0
Impedance of arm (right)	0.2	1.0	1.2	-1.1	-0.9	-1.0
Arm fat percentage (right)	1.7	6.8	16.4	4.0	1.6	-1.3
Trunk fat-free mass	8.5	48.6	95.1	9.8	5.9	-4.0
Hip circumference	5.6	24.1	61.2	7.8	2.9	-1.6
Time employed in main current job	3.2	3.7	5.4	2.0	2.3	-1.3
Alcohol intake versus 10 years previously	1.3	2.0	4.0	-2.0	0.7	-1.3
Father’s age at death	0.1	0.1	0.1	0.3	-0.2	0.3
Worrier / anxious feelings	0.5	1.0	1.8	-1.0	-1.4	-0.1
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.5	7.9	-1.2	-2.8	1.0
Falls in the last year	1.4	1.9	3.2	0.7	-1.8	1.4
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.1	0.1	0.9
Number of live births	0.7	1.0	2.1	-1.4	-0.3	1.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	3.7	1.0	1.9	-1.7
Pulse rate	2.0	3.4	4.7	1.7	1.6	-2.2
Happiness	2.2	2.7	4.9	-0.8	-2.2	1.6
Noisy workplace	2.2	2.8	6.5	-2.5	0.7	1.1
Qualifications: A levels/AS levels or equivalent	3.8	8.4	23.9	4.9	-0.3	-1.1
Serious illness, injury or assault of a close relative in last 2 years	3.0	3.4	6.1	-0.6	-1.9	2.5
Mouth/teeth dental problems: Dentures	0.5	0.8	1.4	-1.2	-0.7	0.6
Asthma	0.9	1.7	2.3	-1.3	-1.0	1.5
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.6	-0.8	-0.4	1.3
Medication: Cholesterol lowering	1.9	3.0	5.7	2.4	-1.2	1.4
Depression (self-reported)	2.0	2.4	4.9	-2.2	-0.9	1.2
Medication: Lansoprazole	2.3	2.6	3.8	-1.5	2.0	-1.3
Prospective memory result	0.4	0.5	0.7	0.6	0.6	-0.8
Lung cancer (father)	0.4	0.4	1.0	1.0	0.2	-0.5
Illnesses of mother	0.0	0.1	0.1	0.1	-0.4	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.3	8.6	1.1	2.9	-1.7
Pulse wave Arterial Stiffness index	1.4	1.6	3.9	2.0	1.0	0.1
Impedance of arm (left)	0.5	2.1	3.2	-1.6	-1.8	-0.7
Arm fat mass (right)	4.1	16.9	37.8	6.1	2.9	-2.1
Trunk predicted mass	8.7	49.6	97.9	9.9	5.9	-4.0
Standing height	7.8	77.0	141.6	11.9	6.7	-6.7
Length of working week for main job	1.1	1.2	2.6	-0.4	1.6	-1.0
Exposure to tobacco smoke at home	0.8	0.9	2.1	1.4	0.4	-0.8
Breastfed as a baby	1.8	2.2	4.9	2.2	0.9	-0.9
Tense / ‘highly strung’	1.0	1.6	4.7	-0.2	-2.2	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.9	-0.6	-1.4	-0.3
Hair/balding pattern: Pattern 4	0.1	0.3	0.7	0.2	-0.1	-0.8
Birth weight of first child	0.8	1.4	3.1	1.8	0.9	-0.5
Peak expiratory flow (PEF)	0.4	0.9	1.8	0.1	-1.4	0.9
Pulse wave reflection index	0.3	0.4	0.5	0.3	-0.7	0.7
Ever highly irritable/argumentative for 2 days	2.1	2.5	3.6	-1.5	-1.9	1.2
Loud music exposure frequency	0.1	0.1	0.3	-0.1	-0.6	0.0
Qualifications: O levels/GCSEs or equivalent	2.8	4.4	13.0	3.6	-0.4	-0.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.5	0.4	-1.2	0.4
Blood clot in the leg (DVT)	2.1	2.7	4.1	-1.9	2.0	-0.5
Medication: Paracetamol	3.5	5.8	9.9	-3.1	-2.7	0.1
Headache pain in last month	2.1	3.6	5.3	-2.3	-2.3	0.5
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	2.0	-0.7	1.4	-1.3
Glaucoma (self-reported)	1.6	1.8	3.8	-1.3	1.9	-0.1
Gout (self-reported)	1.5	2.0	5.8	-2.4	0.4	-0.4
Hypothyroidism/myxoedema (self-reported)	1.8	3.5	5.7	2.4	-1.7	1.4
Medication: Amlodipine	1.0	1.4	3.1	-0.8	-0.7	1.8
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.4	-0.7	0.6	0.2
Birth weight	1.3	2.8	8.1	2.9	0.0	-0.4
Chronic bronchitis/emphysema (mother)	2.1	2.4	5.6	-1.2	-0.6	2.4
High blood pressure (siblings)	0.2	0.3	0.5	0.5	-0.5	0.7
Forced vital capacity (FVC), Best measure	2.9	10.7	16.2	2.7	4.0	-3.0
Body fat percentage	1.7	6.9	16.6	4.1	1.5	-1.4
Leg fat percentage (right)	0.7	2.5	6.7	2.6	0.9	-0.4
Arm fat-free mass (right)	6.9	35.6	73.5	8.6	4.7	-3.3
Exposure to tobacco smoke outside home	0.3	0.4	1.2	1.1	0.1	-0.0
Comparative body size at age 10	2.2	6.0	17.5	4.2	0.2	-0.7
Number of full brothers	2.3	2.9	4.7	-2.2	-2.0	0.4
Worry too long after embarrassment	1.2	2.1	3.7	-1.1	-1.9	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.5	-0.6	-0.7	-0.6
Wheeze or whistling in the chest in last year	2.4	4.3	6.3	-1.8	-2.5	1.8
Number of children fathered	1.0	1.1	2.6	1.6	0.5	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.3	1.0	1.1	-0.5
Age at first live birth	4.2	7.4	19.6	4.4	0.8	-1.4
Pulse wave peak to peak time	0.3	0.4	0.7	-0.8	-0.5	-0.4
Health satisfaction	0.5	0.7	1.2	1.1	-0.1	0.9
Shortness of breath walking on level ground	0.4	0.5	1.1	1.1	-0.6	0.2
Qualifications: College or University degree	3.5	10.9	28.5	5.3	1.0	-1.8
Eye problems/disorders: None of the above	2.0	2.4	3.3	1.8	0.9	-1.8
Mouth/teeth dental problems: Loose teeth	2.9	3.5	4.1	-2.0	-1.8	1.8
Emphysema/chronic bronchitis	0.5	0.6	1.7	0.2	-1.3	-0.2
Medication for pain relief, constipation, heartburn	2.7	4.7	7.9	2.8	2.3	-0.8
Neck or shoulder pain in last month	3.7	5.2	7.8	-1.4	-2.8	2.4
Medication: Blood pressure	0.0	0.1	0.2	-0.1	0.4	0.2
Angina (self-reported)	1.3	1.7	2.6	0.7	-1.6	1.4
Migraine (self-reported)	0.9	1.1	2.5	-1.6	-0.8	-0.3
Medication: Ibuprofen	0.5	0.6	1.5	0.2	-0.5	1.2
Medication: Allopurinol	1.1	1.5	4.5	-2.1	-0.2	0.0
Medication: Omeprazole	1.6	2.0	4.4	-0.9	-2.1	0.8
Medication: Seretide 50 evohaler	0.4	0.5	1.1	0.4	1.0	0.5
Mean time to correctly identify matches	1.1	2.2	2.8	-1.7	-1.1	1.6
Heart disease (mother)	0.9	1.1	3.0	1.7	0.6	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	2.0	-1.4	0.4	-1.1
Whole body fat mass	4.3	17.8	40.4	6.4	2.7	-2.3
Leg fat mass (right)	3.2	12.5	28.7	5.4	2.3	-1.8
Arm predicted mass (right)	6.7	34.3	71.8	8.5	4.6	-3.2
Pulse rate, automated reading	2.0	6.3	8.1	2.3	2.4	-2.8
Alcohol intake frequency.	1.1	2.5	7.1	-2.7	-0.6	-0.2
Comparative height size at age 10	8.3	45.5	106.1	10.3	3.4	-4.3
Number of full sisters	0.9	1.1	3.0	-1.7	0.5	0.2
Suffer from ‘nerves’	1.2	1.9	4.9	-0.9	-2.2	0.1
Overall health rating	0.7	1.5	2.7	-1.7	-0.7	1.2
Chest pain or discomfort	0.0	0.1	0.1	0.1	-0.4	0.0
Had major operations	1.0	1.2	3.3	0.1	-0.4	1.8
Age at last live birth	4.3	6.3	16.3	4.0	1.5	-0.6
Family relationship satisfaction	0.3	0.4	1.1	0.0	-0.3	1.0
Leg pain on walking	0.5	0.6	1.4	0.2	1.2	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.4	-0.6	-0.6	0.5
Commuting to job workplace: Car/motor vehicle	1.2	1.4	2.4	-0.4	1.2	-1.6
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.9	0.7	0.0	-0.9
Medication: Aspirin	0.2	0.2	0.5	0.2	-0.7	0.4
Supplements: Vitamin C	0.4	0.5	1.3	-1.2	-0.0	-0.3
Knee pain experienced in last month	0.7	1.0	2.3	-0.6	-1.5	0.7
Hypertension (Self-reported)	2.1	5.9	7.0	-2.2	-2.6	2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	3.9	-2.0	-0.5	-0.9
Illnesses of father: Heart disease	0.9	1.2	3.2	1.8	-0.3	0.5
Illnesses of siblings: Diabetes	1.6	2.0	3.4	-0.9	-1.9	1.3
Smoking status: Previous	1.5	2.2	3.3	1.8	1.6	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	7.3	15.2	19.0	3.6	3.7	-4.4
Whole body fat-free mass	8.5	48.7	98.0	9.9	5.7	-4.0
Leg fat-free mass (right)	7.9	42.5	88.7	9.4	5.0	-3.7
Arm fat percentage (left)	1.5	5.9	15.4	3.9	1.2	-1.0
Average weekly red wine intake	3.8	5.6	10.9	3.3	-1.8	1.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	0.1	0.3	-0.7
Mood swings	0.9	1.7	3.8	-0.8	-1.9	0.7
Loneliness, isolation	1.8	2.4	5.6	-0.6	-2.4	1.1
Long-standing illness, disability or infirmity	0.7	1.0	2.4	-0.6	-0.7	1.5
Ever had bowel cancer screening	0.1	0.1	0.2	0.4	0.3	-0.0
Diabetes diagnosed by doctor	0.9	1.5	2.4	-0.3	-1.5	1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.1	1.0	-0.7	0.9
Friendships satisfaction	1.2	1.4	2.2	0.9	-1.5	1.1
Qualifications: nursing, teaching	3.1	4.7	12.3	3.5	0.9	-1.1
Commuting to job workplace: Walk	4.5	4.8	6.9	-1.3	-2.4	2.6
Eye problems/disorders: Cataract	0.5	0.6	1.1	-0.8	-1.0	0.2
Mouth/teeth dental problems: Mouth ulcers	5.3	8.4	17.7	-4.2	-2.0	1.9
Medication for cholesterol	1.4	2.2	5.0	0.7	1.0	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.7	0.4	0.9	-0.4
Back pain experienced in last month	0.9	1.3	1.9	-1.4	-0.8	-1.2
Mineral and other dietary supplements	0.6	0.8	1.4	-0.3	-1.2	0.9
Breast cancer (self-reported)	0.1	0.1	0.3	0.5	-0.2	0.2
Asthma (self-reported)	1.0	1.9	2.7	-1.4	-1.1	1.6
Osteoporosis (self-reported)	1.9	2.4	4.1	-2.0	-1.0	1.4
Osteoarthritis (self-reported)	0.4	0.6	1.1	0.3	0.7	-1.0
Medication: Aspirin	0.3	0.3	1.0	1.0	-0.1	-0.1
Medication: Gliclazide	0.2	0.3	0.3	0.6	0.6	0.3
Illnesses of father: None of the above (group 1)	0.6	0.8	1.9	-1.4	-0.5	-0.5
Smoking status: Current	0.6	0.9	1.7	-0.7	-0.7	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	4.9	-1.3	2.2	-1.5
Whole body water mass	8.7	49.4	99.7	10.0	5.7	-4.1
Leg predicted mass (right)	7.9	42.2	88.4	9.4	5.0	-3.7
Arm fat mass (left)	3.9	16.0	38.4	6.2	2.5	-1.8
Number of self-reported non-cancer illnesses	2.1	3.6	5.6	-1.7	-1.5	2.4
Average weekly champagne plus white wine intake	1.6	2.2	6.1	2.5	0.3	0.6
Miserableness	6.6	11.4	13.0	-3.6	-3.4	3.1
Guilty feelings	2.1	3.2	4.7	0.5	-2.1	2.2
Wears glasses or contact lenses	0.9	1.0	2.6	1.6	0.7	0.1
Ever taken oral contraceptive pill	0.7	0.8	2.1	0.5	0.3	1.4
Hearing aid user	0.2	0.2	0.6	0.1	-0.8	-0.2
Mother’s age at death	0.3	0.4	0.8	0.5	0.3	0.9
Financial situation satisfaction	2.9	3.6	6.5	-1.3	-1.7	2.5
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.0	-1.7	-1.0	0.6
Commuting to job workplace: Public transport	0.9	1.0	2.9	1.7	0.4	-0.1
Eye problems/disorders: Glaucoma	1.1	1.2	2.4	-0.8	1.6	0.8
Medication: Blood pressure	2.8	5.3	7.5	-1.6	-2.7	2.4
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.9	1.4	-0.3	-0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.9	0.1	0.9	-0.8
High cholesterol (Self-reported)	2.9	5.2	8.3	-0.6	-2.6	2.9
Medication: Bendroflumethiazide	0.1	0.2	0.3	-0.2	0.4	0.6
Medication: Paracetamol	2.5	3.8	6.6	-2.2	-2.6	0.2
Medication: Lisinopril	0.1	0.2	0.5	-0.7	-0.2	0.2
Medication: Atorvastatin	1.9	2.3	3.2	0.9	-1.7	1.8
Illnesses of father: High blood pressure	0.6	0.7	1.0	-0.6	-1.0	0.9
Alcohol drinker status: Never	2.5	3.0	8.9	-3.0	0.2	-0.0
Ever smoked	0.5	1.0	2.7	1.6	-0.1	0.4
Basal metabolic rate	8.7	48.3	98.8	9.9	5.5	-4.0
Leg fat percentage (left)	0.5	2.0	4.9	2.2	0.8	-0.5
Arm fat-free mass (left)	7.7	39.1	83.2	9.1	4.9	-3.1
Number of operations (self-reported)	0.1	0.1	0.3	-0.0	-0.5	0.2
Average weekly beer plus cider intake	0.1	0.1	0.2	0.4	0.5	0.2
Irritability	2.9	4.8	7.9	-1.8	-2.8	1.9
Risk taking	0.2	0.2	0.5	0.3	-0.3	0.7
Ever had prostate specific antigen (PSA) test	4.3	5.0	13.1	3.6	0.5	-1.2
Fractured/broken bones in last 5 years	0.3	0.4	1.0	1.0	-0.1	0.3
Age started oral contraceptive pill	0.5	0.6	1.6	0.3	-1.3	-0.0
Diastolic blood pressure, automated reading	2.8	8.6	23.5	-4.8	-1.1	0.9
Ever depressed for a whole week	1.3	1.6	3.4	0.4	-1.9	1.1
Unable to work because of sickness or disability	0.6	0.8	1.5	-0.8	-1.2	0.6
Commuting to job workplace: Cycle	0.9	1.1	3.2	1.8	0.2	-0.0
Myopia	0.4	0.6	1.3	1.1	-0.4	0.6
Vascular/heart problems diagnosed by doctor	2.4	6.5	7.4	2.7	2.4	-2.5
Cholesterol lowering medication	3.6	5.4	7.3	-1.5	-2.6	2.7
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	6.8	-0.9	-2.6	0.6
Pain experienced in last month	0.2	0.3	0.6	0.8	0.4	-0.2
Supplements: Calcium	4.0	4.4	6.6	2.3	2.6	-1.1
Basal cell carcinoma (self-reported)	0.4	0.4	1.0	1.0	0.4	-0.3
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.1	1.1	-0.2	0.5
Deep venous thrombosis (DVT) (self-reported)	2.2	2.9	4.7	-1.9	2.2	-0.6
Heart disease (siblings)	0.1	0.1	0.3	-0.3	0.5	-0.2
Alcohol drinker status: Previous	4.6	5.2	9.5	0.4	-3.1	2.5
Pack years of smoking	0.5	0.7	1.3	-0.1	1.1	-0.9
Impedance of whole body	1.3	6.5	13.2	-3.6	-2.5	0.0
Leg fat mass (left)	3.2	12.5	28.7	5.4	2.3	-1.9
Arm predicted mass (left)	7.6	38.6	80.3	9.0	5.0	-3.3