[Hub]/) : Traits : Arm fat-free mass (left) :

chr22:38,787,166-43,226,599

Best TWAS P=3.64e-11 · Best GWAS P=5.86e-15 conditioned to 6.48e-06

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CBX7 0.09 0.07 bslmm 416 0.06 2.7e-07 3.7 5.2 2.5e-07 -0.04 0.97 0.01 FALSE
2 GTEx Adipose Subcutaneous CYP2D6 0.26 0.10 enet 34 0.20 1.2e-16 -3.7 -5.7 1.4e-08 0.45 1.00 0.00 FALSE
3 GTEx Adipose Subcutaneous MGAT3 0.08 0.04 lasso 4 0.04 4.3e-04 -5.5 5.4 7.7e-08 -0.07 0.02 0.98 FALSE
4 GTEx Artery Aorta APOBEC3G 0.40 0.40 lasso 3 0.39 6.3e-23 4.8 5.2 2.2e-07 0.07 0.30 0.70 FALSE
5 GTEx Brain Frontal Cortex BA9 SLC25A17 0.11 -0.01 lasso 5 0.00 3.5e-01 -4.2 -5.2 1.6e-07 0.22 0.08 0.18 FALSE
6 GTEx Breast Mammary Tissue (Male) CYP2D6 0.34 -0.01 lasso 6 0.00 3.2e-01 4.6 -5.2 1.7e-07 0.36 0.11 0.10 FALSE
7 GTEx Breast Mammary Tissue (Female) POLR3H 0.09 -0.01 lasso 6 -0.01 6.4e-01 -5.3 5.4 8.5e-08 -0.46 0.04 0.06 FALSE
8 GTEx Breast Mammary Tissue (Female) DESI1 0.14 0.07 lasso 4 0.11 4.2e-04 -5.3 5.2 2.0e-07 -0.45 0.08 0.12 FALSE
9 GTEx Colon Sigmoid DESI1 0.21 0.08 enet 6 0.11 1.2e-04 -5.3 5.2 2.5e-07 -0.47 0.40 0.05 FALSE
10 GTEx Heart Atrial Appendage MGAT3 0.14 0.14 lasso 2 0.12 3.5e-06 -5.7 5.7 1.5e-08 -0.07 0.01 0.99 TRUE
11 GTEx Lung RP5-821D11.7 0.08 0.02 enet 21 0.04 6.6e-04 3.6 5.8 6.7e-09 -0.40 0.53 0.04 FALSE
12 GTEx Nerve Tibial SYNGR1 0.26 0.18 enet 27 0.21 3.6e-15 -4.8 -5.5 5.1e-08 0.05 0.08 0.92 FALSE
13 GTEx Pituitary APOBEC3G 0.34 0.04 enet 11 0.11 1.2e-03 4.9 5.6 1.8e-08 0.03 0.13 0.22 TRUE
14 GTEx Skin Sun Exposed Lower leg MGAT3 0.13 0.05 lasso 3 0.02 4.7e-03 -5.7 5.7 1.6e-08 -0.08 0.01 0.98 FALSE
15 GTEx Skin Sun Exposed Lower leg APOBEC3G 0.10 0.09 lasso 3 0.06 7.5e-06 4.8 5.2 2.3e-07 0.07 0.31 0.68 FALSE
16 GTEx Spleen CCDC134 0.23 0.00 enet 14 0.09 2.7e-03 -5.3 5.4 6.3e-08 -0.40 0.07 0.07 FALSE
17 GTEx Testis SREBF2 0.25 0.03 lasso 12 0.04 4.6e-03 4.2 5.2 2.6e-07 -0.41 0.62 0.04 FALSE
18 GTEx Vagina APOBEC3G 0.23 0.07 lasso 5 0.06 1.8e-02 4.7 5.3 1.1e-07 0.05 0.10 0.12 FALSE
19 NTR Blood SYNGR1 0.03 0.03 enet 6 0.03 1.0e-10 4.9 5.2 2.1e-07 0.08 0.30 0.70 FALSE
20 The Cancer Genome Atlas Breast Invasive Carcinoma TNRC6B 0.02 0.01 blup 92 0.01 2.7e-03 -5.6 -6.1 9.9e-10 0.12 0.02 0.79 FALSE
21 The Cancer Genome Atlas Colon Adenocarcinoma MKL1 0.05 0.03 blup 105 0.04 3.9e-03 -5.3 -5.2 2.3e-07 0.11 0.02 0.55 FALSE
22 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma WBP2NL 0.06 0.04 blup 140 0.03 9.6e-05 -5.3 5.8 5.0e-09 -0.53 0.58 0.24 TRUE
23 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ADSL 0.04 0.03 enet 6 0.03 1.6e-04 -6.7 -5.5 3.0e-08 0.02 0.00 0.94 FALSE
24 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma WBP2NL 0.10 0.04 blup 140 0.05 1.8e-06 -3.7 5.7 1.3e-08 -0.40 0.98 0.00 FALSE
25 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ADSL 0.07 0.02 blup 33 0.05 5.2e-04 -3.2 -5.3 1.1e-07 0.10 0.07 0.49 FALSE
26 The Cancer Genome Atlas Lung Adenocarcinoma ADSL 0.03 0.00 blup 33 0.01 8.9e-03 -6.4 -5.9 3.7e-09 0.06 0.01 0.60 FALSE
27 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma ADSL 0.06 0.02 lasso 2 0.03 6.6e-03 -6.5 -6.5 9.3e-11 0.05 0.00 0.80 FALSE
28 The Cancer Genome Atlas Pancreatic Adenocarcinoma ADSL 0.09 0.03 lasso 3 0.01 7.7e-02 -6.7 -6.6 3.6e-11 0.11 0.00 0.76 TRUE