Best TWAS P=4.35e-14 · Best GWAS P=9.1e-12 conditioned to 0.0894
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | EIF4E2 | 0.09 | 0.06 | lasso | 1 | 0.05 | 1.7e-04 | 5.2 | -5.2 | 2.0e-07 | 0.04 | 0.78 | 0.02 | FALSE |
2 | GTEx | Heart Atrial Appendage | COPS7B | 0.22 | 0.01 | lasso | 6 | 0.01 | 1.3e-01 | -5.2 | -5.8 | 6.5e-09 | 0.66 | 0.04 | 0.25 | FALSE |
3 | GTEx | Liver | PDE6D | 0.21 | 0.10 | lasso | 4 | 0.09 | 1.8e-03 | -6.8 | -6.8 | 7.9e-12 | 0.81 | 0.01 | 0.89 | TRUE |
4 | ROSMAP | Brain Pre-frontal Cortex | NCL | 0.16 | 0.05 | lasso | 6 | 0.08 | 6.1e-10 | 3.6 | 5.4 | 6.8e-08 | 0.06 | 0.06 | 0.94 | TRUE |
5 | YFS | Blood | EIF4E2 | 0.06 | 0.04 | enet | 27 | 0.04 | 2.8e-13 | 5.2 | 5.7 | 1.1e-08 | -0.04 | 0.99 | 0.01 | FALSE |
6 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | C2orf52 | 0.28 | 0.12 | lasso | 6 | 0.12 | 2.0e-06 | -5.3 | 5.4 | 5.3e-08 | -0.04 | 0.02 | 0.98 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | EFHD1 | 0.11 | 0.01 | blup | 70 | 0.03 | 1.0e-02 | 5.0 | 7.5 | 4.3e-14 | -0.03 | 0.01 | 0.76 | TRUE |
8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GIGYF2 | 0.02 | 0.01 | lasso | 3 | 0.01 | 5.3e-02 | -5.5 | -5.7 | 1.5e-08 | -0.02 | 0.03 | 0.88 | FALSE |
9 | The Cancer Genome Atlas | Lung Adenocarcinoma | CHRNG | 0.04 | 0.00 | blup | 58 | 0.00 | 1.3e-01 | 2.8 | -5.7 | 1.1e-08 | 0.12 | 0.01 | 0.31 | TRUE |
10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | KCNJ13 | 0.07 | 0.07 | blup | 36 | 0.06 | 2.4e-03 | -5.6 | 5.3 | 1.1e-07 | 0.02 | 0.01 | 0.87 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GIGYF2 | 0.04 | 0.00 | blup | 103 | 0.02 | 2.1e-03 | -4.2 | -5.2 | 2.5e-07 | 0.01 | 0.04 | 0.81 | FALSE |
12 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | C2orf52 | 0.21 | 0.20 | lasso | 1 | 0.18 | 1.4e-05 | -5.3 | 5.3 | 1.2e-07 | -0.02 | 0.01 | 0.82 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | KCNJ13 | 0.03 | 0.00 | blup | 35 | 0.01 | 4.3e-02 | 5.0 | -6.3 | 3.1e-10 | -0.02 | 0.01 | 0.56 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | NGEF | 0.04 | 0.03 | enet | 7 | 0.03 | 5.6e-04 | 5.1 | -6.0 | 2.4e-09 | 0.00 | 0.03 | 0.95 | FALSE |