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chr10:103,527,782-105,647,095

Best TWAS P=2.57e-17 · Best GWAS P=2.07e-15 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ACTR1A	0.03	0.01	blup	347	0.01	5.6e-02	4.852	7.2	6.5e-13	0.70	0.06	0.67	FALSE
2	GTEx	Adipose Subcutaneous	WBP1L	0.05	0.00	enet	8	0.00	5.3e-01	-5.752	5.7	1.5e-08	0.43	0.11	0.13	FALSE
3	GTEx	Adipose Subcutaneous	CYP17A1-AS1	0.05	0.02	enet	10	0.03	2.8e-03	4.331	7.3	2.1e-13	0.80	0.03	0.92	TRUE
4	GTEx	Adrenal Gland	TMEM180	0.19	0.15	enet	12	0.09	3.5e-04	-5.313	-7.2	4.2e-13	-0.53	0.27	0.62	FALSE
5	GTEx	Artery Aorta	NT5C2	0.08	0.02	lasso	7	0.01	1.2e-01	-4.186	-6.2	7.4e-10	-0.43	0.07	0.79	FALSE
6	GTEx	Artery Coronary	TMEM180	0.14	0.05	enet	13	0.04	2.4e-02	-5.244	-5.7	1.2e-08	-0.40	0.21	0.21	FALSE
7	GTEx	Artery Coronary	CYP17A1-AS1	0.20	-0.01	enet	21	0.04	2.3e-02	-0.013	5.2	2.5e-07	0.36	0.06	0.15	FALSE
8	GTEx	Artery Tibial	NT5C2	0.06	0.04	lasso	9	0.02	1.5e-02	6.995	-7.3	2.1e-13	-0.74	0.08	0.78	FALSE
9	GTEx	Artery Tibial	CYP17A1-AS1	0.08	0.08	lasso	8	0.06	2.8e-05	6.995	7.0	2.2e-12	0.75	0.32	0.64	FALSE
10	GTEx	Brain Cerebellar Hemisphere	TMEM180	0.23	0.23	lasso	10	0.10	1.3e-03	-5.333	-5.4	6.9e-08	-0.35	0.67	0.14	FALSE
11	GTEx	Brain Cerebellar Hemisphere	ARL3	0.15	0.02	enet	18	0.11	1.1e-03	-6.550	5.9	3.2e-09	0.53	0.10	0.25	FALSE
12	GTEx	Brain Cerebellum	TMEM180	0.25	0.29	enet	11	0.26	3.5e-08	-5.380	-5.8	5.0e-09	-0.38	0.87	0.11	FALSE
13	GTEx	Brain Cerebellum	ARL3	0.20	0.09	enet	32	0.07	3.7e-03	6.440	6.5	1.0e-10	0.66	0.07	0.83	FALSE
14	GTEx	Brain Cerebellum	TRIM8	0.34	-0.01	enet	25	0.07	4.7e-03	-0.926	-5.8	4.8e-09	-0.46	0.08	0.29	TRUE
15	GTEx	Brain Cortex	CYP17A1-AS1	0.15	0.13	lasso	7	0.14	1.3e-04	6.440	7.9	2.2e-15	0.83	0.08	0.77	FALSE
16	GTEx	Brain Hypothalamus	TMEM180	0.21	0.20	lasso	5	0.12	8.5e-04	-5.503	-5.5	4.2e-08	-0.33	0.28	0.07	FALSE
17	GTEx	Brain Hypothalamus	CYP17A1-AS1	0.34	0.10	lasso	10	0.05	2.6e-02	7.937	8.3	8.7e-17	0.93	0.02	0.84	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	CYP17A1-AS1	0.39	0.22	lasso	3	0.19	8.2e-06	6.382	6.2	4.8e-10	0.80	0.08	0.70	FALSE
19	GTEx	Breast Mammary Tissue	TMEM180	0.17	0.16	enet	9	0.17	3.6e-09	-5.503	-5.6	1.9e-08	-0.33	1.00	0.00	FALSE
20	GTEx	Breast Mammary Tissue	CYP17A1-AS1	0.10	-0.01	enet	28	0.00	2.4e-01	7.909	7.2	5.9e-13	0.75	0.05	0.74	FALSE
21	GTEx	Breast Mammary Tissue (Male)	CYP17A1-AS1	0.06	0.00	lasso	3	0.01	2.1e-01	-6.648	7.4	1.3e-13	0.73	0.03	0.18	FALSE
22	GTEx	Breast Mammary Tissue (Female)	TMEM180	0.18	0.06	lasso	4	0.07	4.5e-03	-5.769	-6.6	4.0e-11	-0.42	0.21	0.33	FALSE
23	GTEx	Breast Mammary Tissue (Female)	CYP17A1-AS1	0.14	0.01	lasso	11	0.00	4.7e-01	4.927	7.1	1.1e-12	0.54	0.06	0.21	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	ACTR1A	0.22	0.18	lasso	3	0.19	8.0e-07	-6.129	7.2	5.4e-13	0.70	0.36	0.38	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	RP11-18I14.11	0.17	0.08	lasso	8	0.09	8.7e-04	-7.149	7.5	7.7e-14	0.57	0.17	0.29	FALSE
26	GTEx	Cells Transformed fibroblasts	TMEM180	0.05	0.04	lasso	2	0.01	3.3e-02	-7.301	7.3	2.8e-13	0.56	0.19	0.42	FALSE
27	GTEx	Colon Sigmoid	TMEM180	0.32	0.41	lasso	3	0.38	1.5e-14	-5.380	-5.5	4.8e-08	-0.34	1.00	0.00	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	TMEM180	0.22	0.23	enet	11	0.27	3.0e-10	-5.503	-5.3	1.0e-07	-0.41	0.93	0.05	FALSE
29	GTEx	Esophagus Mucosa	SUFU	0.08	0.02	enet	18	0.01	4.2e-02	-2.761	-6.1	1.2e-09	-0.63	0.46	0.39	FALSE
30	GTEx	Esophagus Muscularis	SUFU	0.07	0.04	enet	18	0.03	5.2e-03	-5.503	-7.7	1.2e-14	-0.56	0.32	0.45	FALSE
31	GTEx	Esophagus Muscularis	TMEM180	0.23	0.22	enet	19	0.19	1.6e-11	-5.503	-5.3	1.1e-07	-0.33	1.00	0.00	FALSE
32	GTEx	Liver	ACTR1A	0.15	0.00	lasso	10	0.00	4.6e-01	-2.985	-6.7	2.7e-11	-0.39	0.05	0.36	FALSE
33	GTEx	Liver	TMEM180	0.28	0.17	enet	36	0.17	1.7e-05	-7.147	-8.5	2.6e-17	-0.62	0.32	0.61	TRUE
34	GTEx	Lung	CYP17A1-AS1	0.06	0.08	lasso	3	0.06	1.6e-05	6.382	6.9	4.8e-12	0.88	0.03	0.96	FALSE
35	GTEx	Muscle Skeletal	WBP1L	0.04	0.00	enet	26	0.02	1.8e-03	4.624	5.2	1.7e-07	0.36	0.09	0.18	FALSE
36	GTEx	Nerve Tibial	CYP17A1-AS1	0.14	0.08	lasso	6	0.06	7.2e-05	6.369	6.5	1.0e-10	0.81	0.43	0.32	FALSE
37	GTEx	Pituitary	NT5C2	0.19	-0.01	lasso	10	0.01	1.8e-01	-5.769	-6.5	1.0e-10	-0.29	0.07	0.06	TRUE
38	GTEx	Skin Sun Exposed Lower leg	SUFU	0.06	0.05	enet	12	0.06	8.4e-06	-7.147	7.2	4.5e-13	0.55	0.46	0.53	FALSE
39	GTEx	Skin Sun Exposed Lower leg	ACTR1A	0.08	0.06	enet	10	0.07	2.7e-06	-7.312	6.0	1.9e-09	0.52	0.39	0.58	FALSE
40	GTEx	Testis	TMEM180	0.19	0.05	enet	24	0.12	7.9e-06	-5.313	-5.2	2.2e-07	-0.43	0.60	0.33	FALSE
41	GTEx	Thyroid	SFXN2	0.28	0.06	enet	32	0.15	1.1e-11	-2.102	-5.2	2.1e-07	-0.74	0.03	0.97	TRUE
42	GTEx	Uterus	TMEM180	0.22	0.00	enet	23	0.00	2.6e-01	-5.244	-6.0	2.1e-09	-0.51	0.05	0.28	FALSE
43	NTR	Blood	ACTR1A	0.03	0.03	enet	19	0.03	1.4e-09	-5.503	7.4	1.2e-13	0.54	0.98	0.02	FALSE
44	NTR	Blood	TRIM8	0.02	0.01	enet	11	0.01	2.1e-03	-5.503	6.1	1.2e-09	0.58	0.40	0.50	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	CYP17A1-AS1	0.15	0.18	lasso	6	0.19	1.3e-23	6.440	6.7	1.9e-11	0.80	1.00	0.00	TRUE
46	YFS	Blood	ARL3	0.39	0.14	enet	30	0.20	7.0e-63	2.431	5.7	9.6e-09	0.56	1.00	0.00	FALSE
47	YFS	Blood	TRIM8	0.04	0.04	lasso	6	0.05	1.2e-15	-5.820	6.4	1.4e-10	0.51	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AS3MT	0.06	0.09	enet	6	0.07	1.3e-06	6.153	-6.5	7.4e-11	-0.62	0.20	0.79	FALSE
49	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C10orf32	0.06	0.06	blup	54	0.08	1.2e-07	3.714	-5.6	2.2e-08	-0.58	0.35	0.65	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	AS3MT	0.05	0.05	enet	10	0.05	4.7e-11	6.153	-5.7	1.2e-08	-0.59	0.90	0.10	FALSE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	C10orf26	0.03	0.02	enet	5	0.02	1.6e-04	-6.548	-6.4	1.9e-10	-0.58	0.87	0.05	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	SFXN2	0.12	0.09	lasso	4	0.10	4.4e-19	5.397	-5.4	5.2e-08	-0.52	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C10orf32	0.16	0.06	blup	54	0.10	1.3e-05	3.714	-5.5	3.6e-08	-0.55	0.04	0.94	FALSE
54	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM180	0.04	0.02	enet	9	0.05	4.2e-04	1.287	5.6	2.1e-08	0.38	0.02	0.82	FALSE
55	The Cancer Genome Atlas	Esophageal Carcinoma	SFXN2	0.26	0.02	blup	48	0.10	4.9e-04	5.397	-6.0	1.8e-09	-0.76	0.01	0.71	FALSE
56	The Cancer Genome Atlas	Glioblastoma Multiforme	AS3MT	0.15	0.05	blup	62	0.10	5.1e-04	3.714	-5.8	5.9e-09	-0.64	0.03	0.72	FALSE
57	The Cancer Genome Atlas	Glioblastoma Multiforme	C10orf32	0.27	0.09	lasso	8	0.17	7.3e-06	4.433	-5.2	1.7e-07	-0.60	0.09	0.69	FALSE
58	The Cancer Genome Atlas	Glioblastoma Multiforme	SFXN2	0.27	0.02	blup	47	0.11	3.1e-04	5.397	-5.3	9.5e-08	-0.70	0.02	0.55	FALSE
59	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ACTR1A	0.02	0.02	lasso	5	0.02	4.6e-03	-5.276	5.5	4.8e-08	0.34	0.02	0.80	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AS3MT	0.05	0.05	blup	62	0.06	1.1e-07	7.289	-5.8	6.8e-09	-0.65	0.16	0.84	FALSE
61	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM180	0.03	0.03	blup	52	0.04	3.9e-05	-7.289	5.8	7.3e-09	0.43	0.02	0.98	TRUE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AS3MT	0.04	0.05	enet	3	0.04	8.6e-06	6.153	-6.2	7.6e-10	-0.61	0.07	0.91	FALSE
63	The Cancer Genome Atlas	Brain Lower Grade Glioma	SUFU	0.03	0.03	lasso	1	0.03	2.0e-04	-5.373	-5.4	7.7e-08	-0.33	0.10	0.87	FALSE
64	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SFXN2	0.20	0.08	blup	48	0.13	9.3e-07	5.397	-5.8	4.8e-09	-0.67	0.13	0.82	TRUE
65	The Cancer Genome Atlas	Lung Adenocarcinoma	TMEM180	0.08	0.07	blup	52	0.09	1.9e-10	-7.149	6.3	2.9e-10	0.51	0.01	0.99	FALSE
66	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM180	0.05	0.02	blup	52	0.04	1.5e-05	-6.314	5.8	7.5e-09	0.48	0.02	0.94	FALSE
67	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SUFU	0.03	0.02	blup	90	0.02	1.5e-02	-7.301	-7.0	2.3e-12	-0.49	0.02	0.78	FALSE
68	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	AS3MT	0.13	0.14	blup	62	0.13	5.6e-06	6.995	-6.6	5.6e-11	-0.71	0.21	0.77	FALSE
69	The Cancer Genome Atlas	Prostate Adenocarcinoma	AS3MT	0.16	0.21	lasso	9	0.24	2.5e-24	6.148	-5.3	9.5e-08	-0.64	0.95	0.05	FALSE
70	The Cancer Genome Atlas	Prostate Adenocarcinoma	C10orf95	0.02	0.03	lasso	2	0.02	4.7e-03	-5.244	-5.3	9.3e-08	-0.33	0.03	0.83	FALSE
71	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM180	0.16	0.27	lasso	4	0.27	4.3e-28	-7.134	-7.1	9.6e-13	-0.54	0.02	0.98	FALSE
72	The Cancer Genome Atlas	Rectum Adenocarcinoma	C10orf32	0.17	0.14	blup	52	0.14	3.2e-04	6.995	-7.1	1.5e-12	-0.71	0.04	0.62	FALSE
73	The Cancer Genome Atlas	Thyroid Carcinoma	AS3MT	0.23	0.18	lasso	3	0.18	1.8e-17	6.148	-5.9	3.0e-09	-0.60	0.99	0.01	FALSE
74	The Cancer Genome Atlas	Thyroid Carcinoma	C10orf26	0.06	0.05	lasso	5	0.04	4.1e-05	6.719	-6.2	6.9e-10	-0.75	0.11	0.82	FALSE
75	The Cancer Genome Atlas	Thyroid Carcinoma	CYP17A1	0.04	0.02	lasso	1	0.02	3.9e-03	7.289	-7.3	3.1e-13	-0.66	0.03	0.70	FALSE