[Hub]/) : Traits : Trunk predicted mass :

chr17:6,518,588-8,765,412

Best TWAS P=6.37e-21 · Best GWAS P=5.78e-21 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CHRNB1 0.09 0.06 lasso 2 0.08 9.8e-10 9.22 8.2 2.8e-16 0.16 0.01 0.99 FALSE
2 CommonMind Brain Pre-frontal Cortex EIF5A 0.20 0.12 bslmm 446 0.10 1.2e-12 -4.07 -6.7 2.5e-11 -0.05 1.00 0.00 TRUE
3 CommonMind Brain Pre-frontal Cortex POLR2A 0.08 0.07 lasso 4 0.07 1.9e-08 7.48 7.7 1.8e-14 0.18 1.00 0.00 FALSE
4 GTEx Adipose Subcutaneous CHRNB1 0.30 0.22 lasso 8 0.26 1.6e-21 -3.46 6.0 1.5e-09 0.06 1.00 0.00 FALSE
5 GTEx Adipose Visceral Omentum CHRNB1 0.29 0.14 lasso 5 0.14 1.0e-07 9.22 9.3 1.9e-20 0.27 0.02 0.98 FALSE
6 GTEx Artery Aorta CHRNB1 0.23 0.10 enet 7 0.13 1.3e-07 -3.40 6.5 7.5e-11 0.09 0.11 0.88 FALSE
7 GTEx Artery Coronary CHRNB1 0.26 0.08 enet 24 0.11 1.3e-04 7.48 5.6 2.3e-08 0.04 0.08 0.70 FALSE
8 GTEx Artery Tibial CHRNB1 0.27 0.20 lasso 5 0.22 8.1e-17 -3.43 6.3 3.7e-10 0.08 0.88 0.12 FALSE
9 GTEx Artery Tibial TNFSF12 0.11 0.06 lasso 2 0.05 1.2e-04 7.39 7.4 1.5e-13 0.52 0.29 0.62 FALSE
10 GTEx Breast Mammary Tissue (Male) CHRNB1 0.28 -0.01 lasso 6 0.02 9.6e-02 9.22 7.3 2.4e-13 0.20 0.03 0.54 TRUE
11 GTEx Cells Transformed fibroblasts CHRNB1 0.28 0.11 enet 25 0.18 2.9e-13 9.22 8.0 1.0e-15 0.46 0.02 0.98 FALSE
12 GTEx Cells Transformed fibroblasts TNFSF12 0.25 0.22 lasso 8 0.20 7.4e-15 -5.46 -5.3 1.0e-07 -0.30 1.00 0.00 FALSE
13 GTEx Colon Sigmoid CHRNB1 0.18 0.06 enet 18 0.11 1.3e-04 -3.43 5.7 1.5e-08 0.17 0.30 0.35 FALSE
14 GTEx Esophagus Mucosa SOX15 0.16 0.03 enet 9 0.07 2.3e-05 9.39 -5.3 1.3e-07 -0.74 0.00 0.98 TRUE
15 GTEx Esophagus Mucosa CHRNB1 0.19 0.11 lasso 2 0.13 7.3e-09 9.22 9.4 6.4e-21 0.29 0.02 0.98 TRUE
16 GTEx Esophagus Mucosa ZBTB4 0.12 0.10 lasso 2 0.08 8.0e-06 7.59 7.5 4.4e-14 0.26 0.94 0.02 TRUE
17 GTEx Esophagus Muscularis CHRNB1 0.35 0.19 lasso 7 0.28 1.9e-17 -3.40 6.0 1.9e-09 0.06 0.97 0.03 FALSE
18 GTEx Esophagus Muscularis ZBTB4 0.13 0.06 lasso 2 0.05 6.3e-04 7.60 7.6 3.7e-14 0.26 0.28 0.25 FALSE
19 GTEx Heart Left Ventricle CHRNB1 0.16 0.03 lasso 4 0.05 9.6e-04 -4.06 5.4 6.2e-08 0.23 0.11 0.22 FALSE
20 GTEx Lung CHRNB1 0.22 0.05 enet 17 0.14 7.5e-11 -2.24 6.3 3.6e-10 0.24 0.41 0.58 TRUE
21 GTEx Muscle Skeletal EIF5A 0.14 0.06 enet 35 0.05 4.2e-06 -3.64 -5.5 3.0e-08 -0.02 0.96 0.00 FALSE
22 GTEx Pancreas TRAPPC1 0.17 0.00 lasso 6 0.01 1.5e-01 7.60 6.2 4.3e-10 0.19 0.09 0.22 FALSE
23 GTEx Prostate RP11-104H15.8 0.54 0.01 enet 1 0.06 1.6e-02 -5.61 -5.6 2.0e-08 -0.17 0.07 0.09 FALSE
24 GTEx Skin Not Sun Exposed Suprapubic CHRNB1 0.17 0.15 lasso 3 0.16 7.4e-09 9.22 9.2 3.9e-20 0.29 0.03 0.97 FALSE
25 GTEx Skin Sun Exposed Lower leg CHRNB1 0.19 0.12 enet 13 0.12 3.0e-10 7.69 7.6 2.2e-14 0.22 0.83 0.17 FALSE
26 GTEx Small Intestine Terminal Ileum CHRNB1 0.43 -0.01 lasso 9 0.00 2.9e-01 0.91 5.3 1.2e-07 -0.03 0.05 0.11 FALSE
27 GTEx Stomach CHRNB1 0.28 0.19 lasso 4 0.23 2.0e-11 9.22 7.8 7.8e-15 0.15 0.02 0.98 FALSE
28 GTEx Whole Blood TNFSF12 0.09 0.03 enet 24 0.04 1.9e-04 -5.51 -7.0 1.9e-12 -0.43 0.47 0.38 TRUE
29 METSIM Adipose CNTROB 0.06 0.02 blup 497 0.03 1.3e-05 1.01 -5.2 2.0e-07 -0.08 0.89 0.00 FALSE
30 METSIM Adipose NEURL4 0.06 0.00 blup 454 0.01 8.2e-03 -0.62 -5.7 1.5e-08 -0.02 0.11 0.02 TRUE
31 ROSMAP Brain Pre-frontal Cortex FGF11 0.08 0.04 blup 454 0.04 1.2e-05 -4.06 5.2 1.5e-07 0.31 0.98 0.00 FALSE
32 ROSMAP Brain Pre-frontal Cortex CHRNB1 0.11 0.08 lasso 6 0.08 7.8e-11 9.22 8.7 3.1e-18 0.30 0.02 0.98 FALSE
33 YFS Blood CHRNB1 0.04 0.02 lasso 5 0.04 8.5e-12 9.23 9.0 2.7e-19 0.31 0.01 0.99 FALSE
34 YFS Blood TMEM107 0.17 0.17 lasso 5 0.19 2.0e-61 -5.95 -6.2 7.7e-10 -0.08 0.46 0.54 TRUE
35 The Cancer Genome Atlas Breast Invasive Carcinoma CHRNB1 0.06 0.06 enet 10 0.06 1.0e-11 9.23 8.4 3.1e-17 0.32 0.00 1.00 FALSE
36 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CHRNB1 0.07 0.04 blup 57 0.05 1.6e-03 9.22 8.3 8.0e-17 0.34 0.00 0.87 FALSE
37 The Cancer Genome Atlas Colon Adenocarcinoma TNFSF12-TNFSF13 0.07 0.05 lasso 3 0.02 1.9e-02 -5.40 -5.5 3.6e-08 -0.22 0.08 0.04 FALSE
38 The Cancer Genome Atlas Glioblastoma Multiforme AMAC1L3 0.14 0.12 lasso 3 0.12 1.8e-04 7.55 -7.7 1.1e-14 -0.25 0.01 0.85 TRUE
39 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ALOXE3 0.04 0.00 blup 77 0.01 3.4e-02 -5.86 -6.0 1.7e-09 0.00 0.01 0.60 FALSE
40 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C17orf68 0.05 0.00 blup 59 0.03 3.3e-04 -5.58 -5.4 6.7e-08 -0.08 0.00 0.94 FALSE
41 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CHRNB1 0.06 0.07 lasso 6 0.07 1.8e-08 5.55 6.9 4.6e-12 0.28 0.53 0.47 FALSE
42 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CHRNB1 0.04 0.03 blup 57 0.02 1.5e-03 -4.49 5.5 3.8e-08 0.34 0.06 0.29 FALSE
43 The Cancer Genome Atlas Brain Lower Grade Glioma CHRNB1 0.05 0.04 blup 57 0.04 6.1e-05 7.73 8.6 1.3e-17 0.23 0.00 1.00 FALSE
44 The Cancer Genome Atlas Brain Lower Grade Glioma TNFSF12 0.05 0.00 blup 56 0.01 1.2e-02 -4.94 -5.2 1.8e-07 0.00 0.14 0.05 FALSE
45 The Cancer Genome Atlas Brain Lower Grade Glioma TNFSF12-TNFSF13 0.07 0.01 enet 17 0.03 4.4e-04 -5.46 -6.0 1.4e-09 -0.08 0.03 0.08 FALSE
46 The Cancer Genome Atlas Lung Adenocarcinoma CHRNB1 0.03 0.02 blup 57 0.02 7.8e-04 9.23 7.9 2.9e-15 0.36 0.00 0.99 FALSE
47 The Cancer Genome Atlas Lung Squamous Cell Carcinoma EFNB3 0.07 0.04 blup 34 0.04 4.0e-05 -6.03 6.0 1.7e-09 0.34 0.16 0.07 TRUE
48 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TNFSF12-TNFSF13 0.06 0.00 blup 58 0.01 3.4e-02 3.42 -5.4 7.5e-08 0.05 0.01 0.06 FALSE
49 The Cancer Genome Atlas Prostate Adenocarcinoma CHRNB1 0.18 0.09 enet 10 0.10 4.9e-11 9.22 8.3 1.2e-16 0.30 0.00 1.00 FALSE
50 The Cancer Genome Atlas Prostate Adenocarcinoma EFNB3 0.06 0.03 lasso 4 0.05 1.0e-05 -6.03 5.4 6.3e-08 0.19 0.91 0.00 FALSE
51 The Cancer Genome Atlas Prostate Adenocarcinoma TNFSF12-TNFSF13 0.03 0.00 lasso 4 0.01 2.9e-02 -5.46 -8.4 5.5e-17 -0.45 0.01 0.66 FALSE
52 The Cancer Genome Atlas Stomach Adenocarcinoma CHRNB1 0.06 0.00 blup 57 0.03 4.5e-03 4.23 8.4 3.1e-17 0.34 0.00 0.76 FALSE
53 The Cancer Genome Atlas Thyroid Carcinoma CHRNB1 0.09 0.02 blup 57 0.05 2.6e-05 -4.06 7.6 2.4e-14 0.23 0.10 0.77 FALSE
54 The Cancer Genome Atlas Thyroid Carcinoma SENP3 0.07 0.04 enet 9 0.03 2.7e-04 4.90 7.9 3.5e-15 0.20 0.12 0.74 TRUE
55 The Cancer Genome Atlas Thyroid Carcinoma SHBG 0.04 0.00 blup 59 0.02 4.4e-03 -4.61 -8.3 1.1e-16 -0.46 0.04 0.08 FALSE