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chr17:27,200,734-30,884,028

Best TWAS P=3.18e-37 · Best GWAS P=2.04e-46 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	NF1	0.06	0.01	blup	410	0.04	1.1e-05	8.11	7.5	9.3e-14	-0.20	0.95	0.00	FALSE
2	GTEx	Adipose Visceral Omentum	TEFM	0.12	0.02	lasso	14	0.05	1.0e-03	1.90	-6.7	2.0e-11	0.21	0.08	0.09	FALSE
3	GTEx	Adipose Visceral Omentum	SUZ12P	0.08	0.07	enet	14	0.07	1.2e-04	3.16	-5.4	5.4e-08	0.38	0.67	0.19	FALSE
4	GTEx	Artery Aorta	ABHD15	0.20	0.03	enet	36	0.06	2.9e-04	-5.98	-8.3	7.1e-17	0.08	0.03	0.54	TRUE
5	GTEx	Artery Aorta	TEFM	0.13	0.02	enet	34	0.03	5.8e-03	1.91	-8.3	1.2e-16	0.57	0.15	0.78	FALSE
6	GTEx	Artery Aorta	CRLF3	0.12	0.03	enet	33	0.06	3.8e-04	1.96	-8.9	5.7e-19	0.53	0.25	0.70	TRUE
7	GTEx	Artery Tibial	RP11-848P1.7	0.54	0.00	lasso	10	0.02	7.3e-03	-7.81	-12.7	3.2e-37	0.47	0.02	0.06	TRUE
8	GTEx	Brain Caudate basal ganglia	TEFM	0.27	0.19	enet	41	0.20	2.7e-06	1.96	-5.2	2.4e-07	0.28	0.66	0.06	FALSE
9	GTEx	Brain Cerebellar Hemisphere	TEFM	0.31	0.28	lasso	6	0.29	3.6e-08	3.12	-5.4	8.4e-08	0.30	0.50	0.28	FALSE
10	GTEx	Brain Cerebellar Hemisphere	CRLF3	0.38	0.35	enet	26	0.35	6.0e-10	3.11	-6.9	6.8e-12	0.32	0.97	0.01	FALSE
11	GTEx	Brain Cerebellum	CRLF3	0.52	0.12	lasso	27	0.20	1.3e-06	-12.00	-10.8	3.0e-27	0.56	0.09	0.74	FALSE
12	GTEx	Breast Mammary Tissue	CRLF3	0.10	0.10	lasso	3	0.05	9.6e-04	3.70	-6.3	3.1e-10	0.31	0.09	0.62	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	EVI2A	0.13	0.03	lasso	4	0.01	1.5e-01	8.11	-8.3	7.2e-17	0.17	0.16	0.04	FALSE
14	GTEx	Cells Transformed fibroblasts	OMG	0.06	0.02	lasso	2	0.01	2.5e-02	8.09	8.1	7.7e-16	-0.22	0.14	0.07	FALSE
15	GTEx	Cells Transformed fibroblasts	TEFM	0.15	0.09	lasso	16	0.09	6.1e-07	1.90	-5.5	3.0e-08	0.45	0.96	0.04	FALSE
16	GTEx	Colon Transverse	CRLF3	0.16	0.07	lasso	6	0.05	1.5e-03	1.96	-6.4	1.5e-10	0.42	0.15	0.64	FALSE
17	GTEx	Esophagus Mucosa	ABHD15	0.21	0.13	lasso	1	0.10	1.7e-07	-5.98	-6.0	2.3e-09	0.00	0.94	0.05	FALSE
18	GTEx	Esophagus Muscularis	BLMH	0.15	0.02	lasso	8	0.01	1.0e-01	-3.88	6.4	1.9e-10	-0.13	0.04	0.46	TRUE
19	GTEx	Esophagus Muscularis	CRLF3	0.17	0.12	lasso	6	0.18	5.1e-11	3.16	-8.5	1.3e-17	0.46	0.94	0.05	FALSE
20	GTEx	Heart Atrial Appendage	ANKRD13B	0.14	0.09	enet	8	0.11	1.2e-05	-5.98	-5.7	1.6e-08	0.04	0.39	0.17	FALSE
21	GTEx	Muscle Skeletal	TP53I13	0.08	0.02	lasso	4	0.02	2.2e-03	-5.98	6.2	5.7e-10	-0.08	0.11	0.09	FALSE
22	GTEx	Nerve Tibial	TEFM	0.16	0.01	lasso	4	0.06	2.7e-05	1.96	-6.2	6.4e-10	0.43	0.26	0.59	FALSE
23	GTEx	Nerve Tibial	CRLF3	0.38	0.16	lasso	14	0.19	3.0e-13	3.30	-7.3	3.9e-13	0.38	1.00	0.00	FALSE
24	GTEx	Nerve Tibial	RP11-68I3.4	0.17	0.12	lasso	5	0.10	6.8e-08	-5.98	5.2	1.5e-07	0.02	0.97	0.03	FALSE
25	GTEx	Nerve Tibial	SUZ12P	0.25	0.34	enet	44	0.35	1.1e-25	3.32	-5.5	3.9e-08	0.29	1.00	0.00	FALSE
26	GTEx	Ovary	CRLF3	0.21	0.14	lasso	4	0.11	1.0e-03	3.16	-7.3	2.4e-13	0.40	0.06	0.58	FALSE
27	GTEx	Pituitary	SUZ12P	0.29	0.23	lasso	9	0.32	6.0e-09	3.11	-7.0	2.1e-12	0.40	0.86	0.07	FALSE
28	GTEx	Prostate	CRLF3	0.26	0.09	lasso	14	0.14	2.7e-04	3.73	-5.3	1.1e-07	0.32	0.16	0.46	FALSE
29	GTEx	Spleen	EVI2A	0.22	0.12	lasso	4	0.07	8.3e-03	7.75	-7.8	6.5e-15	0.17	0.11	0.05	FALSE
30	GTEx	Spleen	OMG	0.41	0.10	enet	26	0.08	4.5e-03	8.09	7.6	2.5e-14	-0.23	0.64	0.03	FALSE
31	GTEx	Testis	CRLF3	0.26	0.19	enet	23	0.17	3.8e-08	3.35	-6.6	4.8e-11	0.38	0.99	0.00	FALSE
32	GTEx	Thyroid	TP53I13	0.14	0.16	enet	7	0.14	6.0e-11	-5.98	5.5	4.5e-08	0.05	0.96	0.04	FALSE
33	GTEx	Thyroid	COPRS	0.17	0.00	enet	43	0.01	1.2e-01	1.21	-5.5	4.5e-08	0.13	0.04	0.18	FALSE
34	GTEx	Thyroid	CRLF3	0.10	0.04	enet	35	0.08	1.1e-06	3.30	-7.0	2.0e-12	0.38	0.91	0.05	FALSE
35	GTEx	Whole Blood	EVI2A	0.07	0.04	lasso	4	0.04	2.6e-04	7.71	-8.0	9.4e-16	0.14	0.89	0.00	FALSE
36	METSIM	Adipose	CTD-2349P21.5	0.02	0.00	bslmm	252	0.01	3.0e-03	-10.35	-8.5	2.6e-17	0.33	0.04	0.31	FALSE
37	METSIM	Adipose	NF1	0.04	0.00	blup	396	0.01	5.5e-03	8.29	8.4	4.6e-17	-0.30	0.80	0.02	FALSE
38	METSIM	Adipose	TEFM	0.08	0.06	blup	246	0.06	8.8e-10	-14.30	-9.0	2.7e-19	0.57	0.00	1.00	TRUE
39	METSIM	Adipose	TP53I13	0.05	0.02	enet	8	0.03	2.7e-05	-3.87	5.2	1.7e-07	-0.04	0.86	0.01	FALSE
40	YFS	Blood	EVI2A	0.03	0.05	lasso	4	0.04	1.0e-13	7.75	-7.8	7.5e-15	0.10	1.00	0.00	FALSE
41	YFS	Blood	EVI2B	0.01	0.00	blup	339	0.00	6.4e-02	0.12	7.9	3.1e-15	-0.26	0.07	0.02	FALSE
42	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EVI2A	0.03	0.03	blup	37	0.03	2.3e-03	7.72	-7.6	2.3e-14	0.10	0.06	0.42	FALSE
43	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	OMG	0.02	0.02	blup	31	0.02	3.2e-03	7.72	-8.3	9.1e-17	0.15	0.03	0.77	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	ABHD15	0.04	0.03	lasso	2	0.02	1.4e-05	-5.98	-6.2	7.8e-10	-0.01	0.46	0.03	TRUE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	EVI2A	0.03	0.03	blup	38	0.03	6.9e-07	7.61	-7.9	2.0e-15	0.12	0.18	0.82	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	GOSR1	0.02	0.01	enet	4	0.01	1.7e-02	-7.86	7.9	3.1e-15	-0.27	0.01	0.83	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	OMG	0.03	0.04	lasso	1	0.04	1.1e-08	8.27	-8.3	1.3e-16	0.23	0.01	0.99	FALSE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	LRRC37B2	0.09	0.00	enet	11	0.03	7.3e-03	3.16	-6.9	4.4e-12	0.47	0.01	0.26	FALSE
49	The Cancer Genome Atlas	Esophageal Carcinoma	OMG	0.09	0.09	blup	31	0.11	2.0e-04	8.36	-8.5	1.9e-17	0.18	0.02	0.92	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EVI2A	0.04	0.00	blup	37	0.01	1.1e-02	7.65	-5.7	1.3e-08	0.00	0.02	0.12	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	OMG	0.02	0.02	blup	31	0.03	6.9e-04	8.29	-8.4	4.9e-17	0.17	0.02	0.89	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	CRLF3	0.07	0.06	blup	37	0.08	2.8e-09	3.32	-5.7	1.2e-08	0.37	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	EVI2A	0.03	0.03	blup	38	0.04	3.0e-05	7.68	-8.4	6.0e-17	0.16	0.04	0.96	FALSE
54	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	NF1	0.04	0.03	blup	111	0.03	1.3e-02	8.34	8.4	4.1e-17	-0.19	0.05	0.68	FALSE
55	The Cancer Genome Atlas	Lung Adenocarcinoma	C17orf42	0.04	0.02	enet	5	0.04	5.4e-05	-1.38	-6.2	4.9e-10	0.46	0.17	0.46	FALSE
56	The Cancer Genome Atlas	Lung Adenocarcinoma	EVI2A	0.04	0.06	blup	38	0.06	3.0e-07	7.57	-8.2	1.7e-16	0.15	0.13	0.87	FALSE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	OMG	0.05	0.03	lasso	5	0.04	3.6e-05	7.59	-6.8	7.9e-12	0.10	0.09	0.80	FALSE
58	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EVI2A	0.03	0.03	lasso	1	0.02	2.4e-03	7.43	-7.4	1.0e-13	0.10	0.05	0.23	FALSE
59	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GOSR1	0.15	0.00	blup	56	0.04	1.1e-03	-3.14	7.1	1.4e-12	-0.35	0.04	0.18	FALSE
60	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	OMG	0.05	0.03	blup	32	0.03	5.6e-03	8.09	-7.9	2.6e-15	0.25	0.01	0.78	FALSE
61	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CRLF3	0.07	0.06	blup	40	0.06	2.0e-03	3.32	-5.6	2.1e-08	0.32	0.09	0.19	FALSE
62	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CRLF3	0.28	0.13	blup	40	0.11	3.1e-05	2.58	-5.9	3.7e-09	0.28	0.33	0.06	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	ATAD5	0.14	0.08	enet	11	0.09	4.1e-10	1.89	5.9	4.4e-09	-0.41	0.99	0.01	FALSE
64	The Cancer Genome Atlas	Prostate Adenocarcinoma	EVI2A	0.08	0.12	lasso	3	0.12	1.3e-12	8.29	-8.2	3.2e-16	0.12	0.16	0.84	FALSE
65	The Cancer Genome Atlas	Stomach Adenocarcinoma	EVI2A	0.05	0.03	enet	7	0.04	4.8e-04	4.61	-7.0	2.9e-12	0.13	0.04	0.63	FALSE
66	The Cancer Genome Atlas	Stomach Adenocarcinoma	SUZ12P	0.05	0.05	blup	29	0.04	5.1e-04	3.70	-6.5	6.1e-11	0.32	0.16	0.16	TRUE
67	The Cancer Genome Atlas	Thyroid Carcinoma	OMG	0.02	0.01	blup	32	0.02	4.8e-03	8.09	-8.4	3.2e-17	0.18	0.02	0.87	FALSE