Best TWAS P=3.18e-37 · Best GWAS P=2.04e-46 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | NF1 | 0.06 | 0.01 | blup | 410 | 0.04 | 1.1e-05 | 8.11 | 7.5 | 9.3e-14 | -0.20 | 0.95 | 0.00 | FALSE |
2 | GTEx | Adipose Visceral Omentum | TEFM | 0.12 | 0.02 | lasso | 14 | 0.05 | 1.0e-03 | 1.90 | -6.7 | 2.0e-11 | 0.21 | 0.08 | 0.09 | FALSE |
3 | GTEx | Adipose Visceral Omentum | SUZ12P | 0.08 | 0.07 | enet | 14 | 0.07 | 1.2e-04 | 3.16 | -5.4 | 5.4e-08 | 0.38 | 0.67 | 0.19 | FALSE |
4 | GTEx | Artery Aorta | ABHD15 | 0.20 | 0.03 | enet | 36 | 0.06 | 2.9e-04 | -5.98 | -8.3 | 7.1e-17 | 0.08 | 0.03 | 0.54 | TRUE |
5 | GTEx | Artery Aorta | TEFM | 0.13 | 0.02 | enet | 34 | 0.03 | 5.8e-03 | 1.91 | -8.3 | 1.2e-16 | 0.57 | 0.15 | 0.78 | FALSE |
6 | GTEx | Artery Aorta | CRLF3 | 0.12 | 0.03 | enet | 33 | 0.06 | 3.8e-04 | 1.96 | -8.9 | 5.7e-19 | 0.53 | 0.25 | 0.70 | TRUE |
7 | GTEx | Artery Tibial | RP11-848P1.7 | 0.54 | 0.00 | lasso | 10 | 0.02 | 7.3e-03 | -7.81 | -12.7 | 3.2e-37 | 0.47 | 0.02 | 0.06 | TRUE |
8 | GTEx | Brain Caudate basal ganglia | TEFM | 0.27 | 0.19 | enet | 41 | 0.20 | 2.7e-06 | 1.96 | -5.2 | 2.4e-07 | 0.28 | 0.66 | 0.06 | FALSE |
9 | GTEx | Brain Cerebellar Hemisphere | TEFM | 0.31 | 0.28 | lasso | 6 | 0.29 | 3.6e-08 | 3.12 | -5.4 | 8.4e-08 | 0.30 | 0.50 | 0.28 | FALSE |
10 | GTEx | Brain Cerebellar Hemisphere | CRLF3 | 0.38 | 0.35 | enet | 26 | 0.35 | 6.0e-10 | 3.11 | -6.9 | 6.8e-12 | 0.32 | 0.97 | 0.01 | FALSE |
11 | GTEx | Brain Cerebellum | CRLF3 | 0.52 | 0.12 | lasso | 27 | 0.20 | 1.3e-06 | -12.00 | -10.8 | 3.0e-27 | 0.56 | 0.09 | 0.74 | FALSE |
12 | GTEx | Breast Mammary Tissue | CRLF3 | 0.10 | 0.10 | lasso | 3 | 0.05 | 9.6e-04 | 3.70 | -6.3 | 3.1e-10 | 0.31 | 0.09 | 0.62 | FALSE |
13 | GTEx | Cells EBV-transformed lymphocytes | EVI2A | 0.13 | 0.03 | lasso | 4 | 0.01 | 1.5e-01 | 8.11 | -8.3 | 7.2e-17 | 0.17 | 0.16 | 0.04 | FALSE |
14 | GTEx | Cells Transformed fibroblasts | OMG | 0.06 | 0.02 | lasso | 2 | 0.01 | 2.5e-02 | 8.09 | 8.1 | 7.7e-16 | -0.22 | 0.14 | 0.07 | FALSE |
15 | GTEx | Cells Transformed fibroblasts | TEFM | 0.15 | 0.09 | lasso | 16 | 0.09 | 6.1e-07 | 1.90 | -5.5 | 3.0e-08 | 0.45 | 0.96 | 0.04 | FALSE |
16 | GTEx | Colon Transverse | CRLF3 | 0.16 | 0.07 | lasso | 6 | 0.05 | 1.5e-03 | 1.96 | -6.4 | 1.5e-10 | 0.42 | 0.15 | 0.64 | FALSE |
17 | GTEx | Esophagus Mucosa | ABHD15 | 0.21 | 0.13 | lasso | 1 | 0.10 | 1.7e-07 | -5.98 | -6.0 | 2.3e-09 | 0.00 | 0.94 | 0.05 | FALSE |
18 | GTEx | Esophagus Muscularis | BLMH | 0.15 | 0.02 | lasso | 8 | 0.01 | 1.0e-01 | -3.88 | 6.4 | 1.9e-10 | -0.13 | 0.04 | 0.46 | TRUE |
19 | GTEx | Esophagus Muscularis | CRLF3 | 0.17 | 0.12 | lasso | 6 | 0.18 | 5.1e-11 | 3.16 | -8.5 | 1.3e-17 | 0.46 | 0.94 | 0.05 | FALSE |
20 | GTEx | Heart Atrial Appendage | ANKRD13B | 0.14 | 0.09 | enet | 8 | 0.11 | 1.2e-05 | -5.98 | -5.7 | 1.6e-08 | 0.04 | 0.39 | 0.17 | FALSE |
21 | GTEx | Muscle Skeletal | TP53I13 | 0.08 | 0.02 | lasso | 4 | 0.02 | 2.2e-03 | -5.98 | 6.2 | 5.7e-10 | -0.08 | 0.11 | 0.09 | FALSE |
22 | GTEx | Nerve Tibial | TEFM | 0.16 | 0.01 | lasso | 4 | 0.06 | 2.7e-05 | 1.96 | -6.2 | 6.4e-10 | 0.43 | 0.26 | 0.59 | FALSE |
23 | GTEx | Nerve Tibial | CRLF3 | 0.38 | 0.16 | lasso | 14 | 0.19 | 3.0e-13 | 3.30 | -7.3 | 3.9e-13 | 0.38 | 1.00 | 0.00 | FALSE |
24 | GTEx | Nerve Tibial | RP11-68I3.4 | 0.17 | 0.12 | lasso | 5 | 0.10 | 6.8e-08 | -5.98 | 5.2 | 1.5e-07 | 0.02 | 0.97 | 0.03 | FALSE |
25 | GTEx | Nerve Tibial | SUZ12P | 0.25 | 0.34 | enet | 44 | 0.35 | 1.1e-25 | 3.32 | -5.5 | 3.9e-08 | 0.29 | 1.00 | 0.00 | FALSE |
26 | GTEx | Ovary | CRLF3 | 0.21 | 0.14 | lasso | 4 | 0.11 | 1.0e-03 | 3.16 | -7.3 | 2.4e-13 | 0.40 | 0.06 | 0.58 | FALSE |
27 | GTEx | Pituitary | SUZ12P | 0.29 | 0.23 | lasso | 9 | 0.32 | 6.0e-09 | 3.11 | -7.0 | 2.1e-12 | 0.40 | 0.86 | 0.07 | FALSE |
28 | GTEx | Prostate | CRLF3 | 0.26 | 0.09 | lasso | 14 | 0.14 | 2.7e-04 | 3.73 | -5.3 | 1.1e-07 | 0.32 | 0.16 | 0.46 | FALSE |
29 | GTEx | Spleen | EVI2A | 0.22 | 0.12 | lasso | 4 | 0.07 | 8.3e-03 | 7.75 | -7.8 | 6.5e-15 | 0.17 | 0.11 | 0.05 | FALSE |
30 | GTEx | Spleen | OMG | 0.41 | 0.10 | enet | 26 | 0.08 | 4.5e-03 | 8.09 | 7.6 | 2.5e-14 | -0.23 | 0.64 | 0.03 | FALSE |
31 | GTEx | Testis | CRLF3 | 0.26 | 0.19 | enet | 23 | 0.17 | 3.8e-08 | 3.35 | -6.6 | 4.8e-11 | 0.38 | 0.99 | 0.00 | FALSE |
32 | GTEx | Thyroid | TP53I13 | 0.14 | 0.16 | enet | 7 | 0.14 | 6.0e-11 | -5.98 | 5.5 | 4.5e-08 | 0.05 | 0.96 | 0.04 | FALSE |
33 | GTEx | Thyroid | COPRS | 0.17 | 0.00 | enet | 43 | 0.01 | 1.2e-01 | 1.21 | -5.5 | 4.5e-08 | 0.13 | 0.04 | 0.18 | FALSE |
34 | GTEx | Thyroid | CRLF3 | 0.10 | 0.04 | enet | 35 | 0.08 | 1.1e-06 | 3.30 | -7.0 | 2.0e-12 | 0.38 | 0.91 | 0.05 | FALSE |
35 | GTEx | Whole Blood | EVI2A | 0.07 | 0.04 | lasso | 4 | 0.04 | 2.6e-04 | 7.71 | -8.0 | 9.4e-16 | 0.14 | 0.89 | 0.00 | FALSE |
36 | METSIM | Adipose | CTD-2349P21.5 | 0.02 | 0.00 | bslmm | 252 | 0.01 | 3.0e-03 | -10.35 | -8.5 | 2.6e-17 | 0.33 | 0.04 | 0.31 | FALSE |
37 | METSIM | Adipose | NF1 | 0.04 | 0.00 | blup | 396 | 0.01 | 5.5e-03 | 8.29 | 8.4 | 4.6e-17 | -0.30 | 0.80 | 0.02 | FALSE |
38 | METSIM | Adipose | TEFM | 0.08 | 0.06 | blup | 246 | 0.06 | 8.8e-10 | -14.30 | -9.0 | 2.7e-19 | 0.57 | 0.00 | 1.00 | TRUE |
39 | METSIM | Adipose | TP53I13 | 0.05 | 0.02 | enet | 8 | 0.03 | 2.7e-05 | -3.87 | 5.2 | 1.7e-07 | -0.04 | 0.86 | 0.01 | FALSE |
40 | YFS | Blood | EVI2A | 0.03 | 0.05 | lasso | 4 | 0.04 | 1.0e-13 | 7.75 | -7.8 | 7.5e-15 | 0.10 | 1.00 | 0.00 | FALSE |
41 | YFS | Blood | EVI2B | 0.01 | 0.00 | blup | 339 | 0.00 | 6.4e-02 | 0.12 | 7.9 | 3.1e-15 | -0.26 | 0.07 | 0.02 | FALSE |
42 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | EVI2A | 0.03 | 0.03 | blup | 37 | 0.03 | 2.3e-03 | 7.72 | -7.6 | 2.3e-14 | 0.10 | 0.06 | 0.42 | FALSE |
43 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | OMG | 0.02 | 0.02 | blup | 31 | 0.02 | 3.2e-03 | 7.72 | -8.3 | 9.1e-17 | 0.15 | 0.03 | 0.77 | FALSE |
44 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ABHD15 | 0.04 | 0.03 | lasso | 2 | 0.02 | 1.4e-05 | -5.98 | -6.2 | 7.8e-10 | -0.01 | 0.46 | 0.03 | TRUE |
45 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EVI2A | 0.03 | 0.03 | blup | 38 | 0.03 | 6.9e-07 | 7.61 | -7.9 | 2.0e-15 | 0.12 | 0.18 | 0.82 | FALSE |
46 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GOSR1 | 0.02 | 0.01 | enet | 4 | 0.01 | 1.7e-02 | -7.86 | 7.9 | 3.1e-15 | -0.27 | 0.01 | 0.83 | FALSE |
47 | The Cancer Genome Atlas | Breast Invasive Carcinoma | OMG | 0.03 | 0.04 | lasso | 1 | 0.04 | 1.1e-08 | 8.27 | -8.3 | 1.3e-16 | 0.23 | 0.01 | 0.99 | FALSE |
48 | The Cancer Genome Atlas | Colon Adenocarcinoma | LRRC37B2 | 0.09 | 0.00 | enet | 11 | 0.03 | 7.3e-03 | 3.16 | -6.9 | 4.4e-12 | 0.47 | 0.01 | 0.26 | FALSE |
49 | The Cancer Genome Atlas | Esophageal Carcinoma | OMG | 0.09 | 0.09 | blup | 31 | 0.11 | 2.0e-04 | 8.36 | -8.5 | 1.9e-17 | 0.18 | 0.02 | 0.92 | FALSE |
50 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EVI2A | 0.04 | 0.00 | blup | 37 | 0.01 | 1.1e-02 | 7.65 | -5.7 | 1.3e-08 | 0.00 | 0.02 | 0.12 | FALSE |
51 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | OMG | 0.02 | 0.02 | blup | 31 | 0.03 | 6.9e-04 | 8.29 | -8.4 | 4.9e-17 | 0.17 | 0.02 | 0.89 | FALSE |
52 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CRLF3 | 0.07 | 0.06 | blup | 37 | 0.08 | 2.8e-09 | 3.32 | -5.7 | 1.2e-08 | 0.37 | 1.00 | 0.00 | FALSE |
53 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EVI2A | 0.03 | 0.03 | blup | 38 | 0.04 | 3.0e-05 | 7.68 | -8.4 | 6.0e-17 | 0.16 | 0.04 | 0.96 | FALSE |
54 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | NF1 | 0.04 | 0.03 | blup | 111 | 0.03 | 1.3e-02 | 8.34 | 8.4 | 4.1e-17 | -0.19 | 0.05 | 0.68 | FALSE |
55 | The Cancer Genome Atlas | Lung Adenocarcinoma | C17orf42 | 0.04 | 0.02 | enet | 5 | 0.04 | 5.4e-05 | -1.38 | -6.2 | 4.9e-10 | 0.46 | 0.17 | 0.46 | FALSE |
56 | The Cancer Genome Atlas | Lung Adenocarcinoma | EVI2A | 0.04 | 0.06 | blup | 38 | 0.06 | 3.0e-07 | 7.57 | -8.2 | 1.7e-16 | 0.15 | 0.13 | 0.87 | FALSE |
57 | The Cancer Genome Atlas | Lung Adenocarcinoma | OMG | 0.05 | 0.03 | lasso | 5 | 0.04 | 3.6e-05 | 7.59 | -6.8 | 7.9e-12 | 0.10 | 0.09 | 0.80 | FALSE |
58 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | EVI2A | 0.03 | 0.03 | lasso | 1 | 0.02 | 2.4e-03 | 7.43 | -7.4 | 1.0e-13 | 0.10 | 0.05 | 0.23 | FALSE |
59 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | GOSR1 | 0.15 | 0.00 | blup | 56 | 0.04 | 1.1e-03 | -3.14 | 7.1 | 1.4e-12 | -0.35 | 0.04 | 0.18 | FALSE |
60 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | OMG | 0.05 | 0.03 | blup | 32 | 0.03 | 5.6e-03 | 8.09 | -7.9 | 2.6e-15 | 0.25 | 0.01 | 0.78 | FALSE |
61 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CRLF3 | 0.07 | 0.06 | blup | 40 | 0.06 | 2.0e-03 | 3.32 | -5.6 | 2.1e-08 | 0.32 | 0.09 | 0.19 | FALSE |
62 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CRLF3 | 0.28 | 0.13 | blup | 40 | 0.11 | 3.1e-05 | 2.58 | -5.9 | 3.7e-09 | 0.28 | 0.33 | 0.06 | FALSE |
63 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ATAD5 | 0.14 | 0.08 | enet | 11 | 0.09 | 4.1e-10 | 1.89 | 5.9 | 4.4e-09 | -0.41 | 0.99 | 0.01 | FALSE |
64 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EVI2A | 0.08 | 0.12 | lasso | 3 | 0.12 | 1.3e-12 | 8.29 | -8.2 | 3.2e-16 | 0.12 | 0.16 | 0.84 | FALSE |
65 | The Cancer Genome Atlas | Stomach Adenocarcinoma | EVI2A | 0.05 | 0.03 | enet | 7 | 0.04 | 4.8e-04 | 4.61 | -7.0 | 2.9e-12 | 0.13 | 0.04 | 0.63 | FALSE |
66 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SUZ12P | 0.05 | 0.05 | blup | 29 | 0.04 | 5.1e-04 | 3.70 | -6.5 | 6.1e-11 | 0.32 | 0.16 | 0.16 | TRUE |
67 | The Cancer Genome Atlas | Thyroid Carcinoma | OMG | 0.02 | 0.01 | blup | 32 | 0.02 | 4.8e-03 | 8.09 | -8.4 | 3.2e-17 | 0.18 | 0.02 | 0.87 | FALSE |