Hub : Genes

GFAP

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0487 0.0192 2.1e-05 0.044 0.039 0.037 0.042 0.047 3.2e-07 1.3e-06 2.4e-06 5.5e-07 1.2e-07
2 TCGA Thyroid Carcinoma 0.0860 0.0450 2.9e-04 0.052 0.031 0.032 NA 0.045 7.4e-06 4.5e-04 4.0e-04 NA 3.4e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.9 3.1 4.4 -1.3 2.1
Bipolar Disorder or Schizophrenia 0.3 0.8 1.5 -0.2 1.2
Depressed Affect (Nagel 2018) 0.4 0.9 1.5 -0.5 1.2
Depression (Nagel 2018) 1.0 1.5 1.7 -1.3 1.1
Intelligence (Savage-Jansen 2018) 1.3 4.1 8.1 0.0 -2.8
Neuroticism (Nagel 2018) 0.9 2.1 2.5 -1.3 1.6
Schizophrenia (2018) 0.1 0.3 0.6 0.8 -0.1
Schizophrenia vs Biploar Disorder 0.9 1.1 2.0 1.4 -0.5
Worry (Nagel 2018) 0.2 0.4 0.7 -0.8 0.4
Alzheimer’s Disease (in mother) 4.1 4.8 6.7 1.7 -2.6
Alzheimer’s Disease (in father) 0.4 0.4 0.8 0.3 -0.9
Alzheimer’s Disease (including proxy) 2.1 3.0 4.2 1.3 -2.0
Crohns Disease (2017) 0.5 1.2 1.9 0.7 -1.4
Irritable Bowel Disease (IBD) 1.7 4.0 4.8 1.8 -2.2
Ulcerative Colitis (UC) 1.6 3.0 3.3 1.8 -1.7
Major Depression (MDD) 0.3 0.4 0.6 0.3 -0.8
Reaction Time 0.4 0.7 1.1 0.6 1.0
Verbal and Numeric Reasoning (VNR) 0.9 2.1 3.8 0.6 -2.0
Breast Cancer 0.5 1.1 1.7 -1.3 0.8
Ovarian Cancer 0.6 0.7 1.4 -1.2 0.2
Prostate Cancer 0.1 0.2 0.4 -0.6 0.1
Age at First Birth 0.5 0.7 1.3 -0.2 -1.1
Bipolar Disorder (2011) 1.8 1.7 1.9 -1.2 1.4
Body Mass Index (BMI) (2010) 0.0 0.0 0.0 0.1 -0.2
Coronary Artery Disease (CAD) 0.4 0.5 0.6 0.6 -0.8
Crohns Disease (2012) 0.4 0.7 0.8 0.7 -0.9
Mean Putamen Volume 0.8 0.9 1.6 0.4 -1.3
Fasting Glucose 0.5 0.5 1.0 1.0 -0.2
HbA1C 2.1 2.4 3.7 -1.0 1.9
HDL Cholesterol 0.9 1.5 1.9 1.0 -1.4
LDL Cholesterol 5.0 8.0 14.5 -1.2 3.8
Lupus 0.1 0.2 0.3 0.3 -0.5
Neuroticism (2016) 0.5 0.8 1.1 -1.1 0.7
Primary Biliary Cirrhosis 0.3 0.4 0.7 0.9 -0.2
Rheumatoid Arthritis 0.1 0.2 0.3 0.1 -0.6
Schizophrenia (2014) 0.2 0.6 0.8 0.9 0.6
Triglycerides 1.8 2.9 4.7 -1.0 2.2
Type 2 Diabetes (T2D) (2012) 0.1 0.2 0.2 0.3 0.5
Ulcerative Colitis 0.9 1.3 1.4 1.1 -1.2
Blood Eosinophil Count 0.2 1.2 2.3 1.5 -0.3
Blood Platelet Count 1.1 12.4 20.8 -2.0 4.6
Blood Red Count 0.1 0.6 0.9 -0.5 -0.9
Blood White Count 0.4 2.6 4.9 2.2 0.5
Heel T-Score 0.3 2.5 4.7 -0.6 -2.2
BMI 0.3 1.5 2.9 1.7 -0.3
Height 1.9 36.0 53.0 4.4 -7.3
Waist Hip Ratio (WHR) 0.4 1.8 2.4 -1.1 1.6
Systolic Blood Pressure 0.0 0.0 0.0 0.1 0.1
Smoking Status 0.2 0.4 0.8 0.1 0.9
Allergy or Eczema 0.2 0.5 1.1 -0.0 -1.0
Cardiovascular Disease 0.2 0.5 1.0 1.0 0.2
Hypothyroidism (self reported) 0.0 0.0 0.0 -0.1 0.1
Respiratory disease 0.0 0.0 0.0 0.2 -0.0
Type 2 Diabetes (T2D) (2018) 0.3 0.6 0.9 1.0 -0.6
Lung FEV1/FVC ratio 0.3 1.4 2.0 -1.0 1.4
Lung FVC 4.9 25.0 31.9 4.2 -5.7
Neuroticism 0.8 1.9 2.1 -1.4 1.3
Chronotype (morning person) 3.2 7.4 7.7 2.7 -2.8
Hair Pigment 0.0 0.9 1.7 1.3 0.0
Tanning 0.4 4.7 6.5 2.6 -1.7
Hand grip strength (left) 9.7 25.6 36.9 3.8 -6.1
Number of treatments/medications taken 0.3 0.6 1.1 1.0 -0.3
Average weekly spirits intake 0.2 0.2 0.3 -0.5 0.4
Sensitivity / hurt feelings 1.3 2.3 3.6 -1.0 1.9
Frequency of depressed mood in last 2 weeks 3.1 4.4 5.8 -2.4 1.7
Hearing difficulty/problems: Yes 0.5 0.7 1.4 -0.3 -1.2
Relative age of first facial hair 0.7 1.4 1.5 -1.2 1.1
Other serious medical condition/disability diagnosed by doctor 1.8 2.4 2.6 -1.6 1.5
Ever used hormone-replacement therapy (HRT) 0.4 0.5 0.8 -0.9 0.5
Ever had hysterectomy (womb removed) 0.6 0.7 1.2 1.1 -0.4
Systolic blood pressure, automated reading 0.2 0.6 1.1 -0.4 1.0
Eye problems/disorders: Diabetes related eye disease 1.7 1.9 3.0 -0.9 1.7
Angina 1.7 2.2 3.6 -0.9 1.9
Medication for hormone replacement therapy 0.5 0.5 0.7 -0.8 -0.6
Vitamin and mineral supplements 0.1 0.2 0.3 0.6 -0.3
Supplements: Zinc 1.2 1.3 2.0 -1.4 0.8
Medication: Co-codamol 0.5 0.6 1.2 1.1 -0.1
Medication: Metformin 0.2 0.3 0.5 0.7 -0.2
Diabetes (father) 0.4 0.5 1.0 0.3 -1.0
Diabetes (mother) 0.2 0.2 0.4 0.7 0.0
Severe depression (siblings) 0.6 0.7 0.9 -0.9 0.7
Pack years adult smoking proportion 1.4 2.1 2.3 -1.5 1.4
Impedance of leg (right) 1.4 6.6 11.4 -1.4 3.4
Leg fat-free mass (left) 2.3 12.3 17.8 2.6 -4.2
Trunk fat percentage 0.4 1.6 2.1 1.1 1.4
Hand grip strength (right) 6.3 17.1 24.3 3.1 -4.9
Townsend deprivation index at recruitment 1.2 1.8 3.4 -0.4 1.8
Current tobacco smoking 0.6 0.9 1.5 -0.5 1.2
Average weekly fortified wine intake 0.4 0.5 0.7 -0.5 0.8
Maternal smoking around birth 0.0 0.0 0.1 -0.1 0.2
Fed-up feelings 0.3 0.5 0.8 -0.4 0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.4 -0.6 0.4
Relative age voice broke 0.3 0.5 1.1 1.0 -0.1
Taking other prescription medications 1.0 1.5 2.5 1.6 -0.7
Age when periods started (menarche) 3.3 7.9 8.6 -2.7 2.9
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.4 0.6 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.1 0.1 0.2 0.4
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.6 -0.8 0.3
Qualifications: CSEs or equivalent 0.1 0.1 0.2 0.5 0.2
Serious illness, injury or assault to yourself 1.4 1.6 3.3 -1.8 0.1
High blood pressure 0.4 1.0 1.2 1.1 -0.9
Hayfever, allergic rhinitis or eczema 0.5 1.0 1.8 0.4 -1.4
Multivitamins +/- minerals 0.1 0.2 0.3 0.1 -0.6
Stomach or abdominal pain in last month 0.0 0.1 0.1 -0.3 0.1
Supplements: Glucosamine 0.1 0.1 0.2 0.3 -0.5
Diverticular disease/diverticulitis (self-reported) 4.0 4.7 7.9 1.2 -2.8
Medication: Atenolol 0.1 0.1 0.2 0.1 0.4
Medication: Levothyroxine sodium 0.1 0.2 0.4 0.0 0.7
Sitting height 3.3 23.7 40.1 2.7 -6.3
Chronic bronchitis/emphysema (father) 0.5 0.5 0.8 -0.9 0.5
High blood pressure (mother) 0.0 0.0 0.1 0.0 -0.3
Body mass index (BMI) 0.1 0.5 1.0 1.0 -0.0
Impedance of leg (left) 1.2 5.6 10.5 -0.9 3.2
Leg predicted mass (left) 2.3 12.4 18.0 2.6 -4.2
Trunk fat mass 0.3 1.3 2.6 1.6 -0.1
Waist circumference 0.0 0.2 0.3 0.2 0.5
Number of incorrect matches in round 0.6 1.1 2.0 0.3 1.4
Past tobacco smoking 0.1 0.3 0.4 -0.4 -0.6
Alcohol usually taken with meals 0.5 0.7 0.7 -0.9 -0.9
Nervous feelings 0.4 0.8 1.2 -0.6 1.1
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.1 -1.0 0.4
Hearing difficulty/problems with background noise 0.3 0.4 0.8 -0.9 0.3
Hair/balding pattern: Pattern 2 6.1 7.7 9.9 -2.3 3.1
Had menopause 1.2 1.6 2.5 -1.6 0.8
Had other major operations 0.1 0.1 0.3 -0.1 -0.5
Forced vital capacity (FVC) 5.9 22.6 28.8 4.0 -5.4
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.2 0.1 0.4
Ever unenthusiastic/disinterested for a whole week 5.2 6.3 6.8 -2.4 2.6
Qualifications: None of the above 0.8 1.8 3.1 0.7 1.8
Financial difficulties in last 2 years 2.1 2.8 3.9 1.3 -2.0
Mouth/teeth dental problems 0.0 0.0 0.1 0.2 0.1
Heart attack 1.6 2.0 2.0 -1.4 1.4
Allergy 0.2 0.4 0.8 -0.1 0.9
Pain all over the body in last month 1.8 1.9 2.3 -1.3 1.5
Diabetes (self-reported) 0.5 0.7 1.1 0.5 -1.1
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.8 -0.9 -0.2
Medication: Ramipril 0.4 0.5 0.9 -0.9 -0.4
Medication: Simvastatin 0.5 0.7 1.4 0.0 1.2
Fluid intelligence score 1.4 2.9 4.1 1.3 -2.0
Illnesses of siblings 1.8 2.5 3.1 1.7 -1.4
Neuroticism score 1.5 3.2 3.8 -1.9 1.6
Weight 1.1 5.2 5.6 2.2 -2.4
Impedance of arm (right) 0.6 2.6 5.0 -0.5 2.2
Arm fat percentage (right) 0.2 1.0 1.5 0.7 1.2
Trunk fat-free mass 2.9 16.5 27.5 2.3 -5.2
Hip circumference 0.1 0.3 0.5 0.7 -0.3
Time employed in main current job 0.9 1.1 1.9 1.4 -0.5
Alcohol intake versus 10 years previously 0.3 0.4 0.4 -0.6 0.7
Father’s age at death 1.8 2.4 4.7 -2.2 -0.3
Worrier / anxious feelings 0.5 1.0 1.6 -0.7 1.3
Frequency of tiredness / lethargy in last 2 weeks 1.7 2.8 3.8 -1.9 1.3
Falls in the last year 1.1 1.4 1.7 -1.1 1.3
Hair/balding pattern: Pattern 3 3.1 4.7 5.2 2.0 -2.3
Number of live births 1.5 2.1 4.2 2.0 0.1
Forced expiratory volume in 1-second (FEV1) 4.2 14.2 17.9 3.2 -4.2
Pulse rate 0.4 0.8 1.2 -0.6 -1.1
Happiness 0.5 0.6 0.7 -0.8 0.8
Noisy workplace 0.7 0.8 1.4 1.2 -0.5
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.4 -0.2 -0.6
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.3 -0.5 1.1
Mouth/teeth dental problems: Dentures 1.0 1.7 3.1 1.8 -0.4
Asthma 0.4 0.8 0.8 0.9 -0.9
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.8 0.2 -1.4
Medication: Cholesterol lowering 0.7 1.1 2.1 -0.1 1.4
Depression (self-reported) 1.8 2.1 3.9 -2.0 0.6
Medication: Lansoprazole 0.4 0.5 0.9 -0.3 0.9
Prospective memory result 0.3 0.4 0.7 -0.3 0.9
Lung cancer (father) 0.7 0.8 1.0 0.7 1.0
Illnesses of mother 1.0 1.2 2.3 -0.2 1.5
Forced expiratory volume in 1-second (FEV1), Best measure 5.9 18.8 23.8 3.7 -4.9
Pulse wave Arterial Stiffness index 1.8 2.1 2.9 -1.7 1.2
Impedance of arm (left) 0.9 4.2 8.2 -0.6 2.9
Arm fat mass (right) 0.3 1.2 2.3 1.5 -0.4
Trunk predicted mass 2.9 16.5 27.7 2.3 -5.3
Standing height 1.8 17.8 27.8 2.8 -5.3
Length of working week for main job 0.2 0.3 0.4 0.6 0.4
Exposure to tobacco smoke at home 1.4 1.6 3.1 -0.4 1.8
Breastfed as a baby 0.3 0.3 0.6 0.1 -0.8
Tense / ‘highly strung’ 0.1 0.2 0.2 -0.3 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.5 -0.7 0.1
Hair/balding pattern: Pattern 4 0.7 1.6 2.7 1.6 -0.8
Birth weight of first child 0.4 0.8 1.3 0.5 -1.1
Peak expiratory flow (PEF) 0.6 1.4 2.3 0.7 -1.5
Pulse wave reflection index 0.3 0.3 0.5 0.7 -0.4
Ever highly irritable/argumentative for 2 days 0.0 0.0 0.0 0.1 0.0
Loud music exposure frequency 1.6 1.8 2.2 -1.5 1.1
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.3 -1.1 -0.0
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 2.5 -1.6 0.9
Blood clot in the leg (DVT) 1.3 1.7 3.4 -0.3 1.8
Medication: Paracetamol 0.3 0.5 0.9 1.0 -0.0
Headache pain in last month 0.4 0.6 0.7 -0.8 -0.7
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 1.3 -1.1 -0.7
Glaucoma (self-reported) 0.2 0.2 0.3 -0.4 0.5
Gout (self-reported) 0.6 0.9 1.6 0.3 1.3
Hypothyroidism/myxoedema (self-reported) 0.0 0.0 0.0 0.1 0.2
Medication: Amlodipine 1.0 1.3 2.7 1.6 -0.0
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.2 0.4 0.4
Birth weight 1.3 2.8 4.7 -2.2 1.0
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.4 0.6 -0.2
High blood pressure (siblings) 0.2 0.3 0.6 -0.7 0.2
Forced vital capacity (FVC), Best measure 7.5 27.3 34.1 4.5 -5.8
Body fat percentage 0.3 1.4 2.1 0.8 1.5
Leg fat percentage (right) 0.4 1.5 3.0 0.3 1.7
Arm fat-free mass (right) 2.3 11.6 17.3 2.4 -4.2
Exposure to tobacco smoke outside home 0.6 0.9 1.0 -0.8 1.0
Comparative body size at age 10 0.1 0.2 0.3 -0.6 -0.0
Number of full brothers 5.8 7.3 9.8 -3.1 2.2
Worry too long after embarrassment 1.6 2.7 3.8 -1.9 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 2.2 -1.5 1.0
Wheeze or whistling in the chest in last year 0.7 1.2 2.0 1.4 -0.7
Number of children fathered 0.2 0.2 0.4 -0.7 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.4 0.4 0.6
Age at first live birth 1.9 3.3 5.3 -1.2 -2.3
Pulse wave peak to peak time 2.1 2.5 3.0 1.7 -1.4
Health satisfaction 0.0 0.0 0.0 0.2 -0.1
Shortness of breath walking on level ground 1.8 2.1 3.4 -0.9 1.9
Qualifications: College or University degree 1.2 3.8 7.2 0.6 -2.7
Eye problems/disorders: None of the above 6.1 7.0 8.0 2.8 -2.5
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.2 0.4 0.5
Emphysema/chronic bronchitis 0.8 1.0 1.2 -0.9 1.1
Medication for pain relief, constipation, heartburn 0.8 1.3 1.5 -1.2 1.0
Neck or shoulder pain in last month 0.2 0.3 0.4 0.3 -0.6
Medication: Blood pressure 0.9 1.5 2.4 1.6 -0.8
Angina (self-reported) 1.1 1.4 2.3 -0.8 1.5
Migraine (self-reported) 2.1 2.7 3.5 1.9 -1.3
Medication: Ibuprofen 0.5 0.6 1.2 0.2 -1.1
Medication: Allopurinol 0.5 0.7 1.3 -0.2 1.2
Medication: Omeprazole 0.6 0.7 0.9 0.7 -1.0
Medication: Seretide 50 evohaler 1.4 1.6 2.3 0.9 -1.5
Mean time to correctly identify matches 1.3 2.4 4.6 -0.4 2.1
Heart disease (mother) 2.2 2.7 4.8 -2.2 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 1.2 0.9 -1.1
Whole body fat mass 0.3 1.3 2.6 1.6 -0.3
Leg fat mass (right) 0.3 1.1 2.1 1.5 -0.2
Arm predicted mass (right) 2.1 10.5 16.1 2.2 -4.0
Pulse rate, automated reading 0.2 0.5 1.0 0.1 -1.0
Alcohol intake frequency. 0.3 0.6 0.6 0.8 -0.8
Comparative height size at age 10 2.8 15.5 15.7 3.9 -4.0
Number of full sisters 1.6 1.9 2.9 1.7 -0.9
Suffer from ‘nerves’ 0.1 0.2 0.4 0.6 -0.3
Overall health rating 0.0 0.0 0.1 0.2 0.2
Chest pain or discomfort 0.2 0.4 0.7 0.8 0.0
Had major operations 1.3 1.5 2.3 -1.5 0.8
Age at last live birth 1.9 2.7 5.4 -0.1 -2.3
Family relationship satisfaction 0.2 0.2 0.4 0.2 0.6
Leg pain on walking 1.1 1.4 1.8 1.0 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 -0.2 0.4
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.1 0.2 0.3
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.0 -0.1 -0.1
Medication: Aspirin 0.5 0.6 0.8 0.9 -0.7
Supplements: Vitamin C 2.2 2.6 3.3 -1.4 1.8
Knee pain experienced in last month 0.3 0.5 0.9 0.9 -0.2
Hypertension (Self-reported) 0.3 0.8 0.9 0.9 -0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 0.6 -0.8 0.6
Illnesses of father: Heart disease 0.1 0.2 0.2 -0.4 -0.4
Illnesses of siblings: Diabetes 0.2 0.2 0.2 -0.4 0.5
Smoking status: Previous 0.3 0.4 0.8 0.9 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 3.4 0.3 -1.9
Whole body fat-free mass 2.9 16.4 25.8 2.6 -5.1
Leg fat-free mass (right) 2.6 13.7 20.0 2.7 -4.5
Arm fat percentage (left) 0.3 1.2 2.0 0.6 1.4
Average weekly red wine intake 1.3 2.0 2.0 1.4 -1.4
Handedness (chirality/laterality): Left-handed 0.0 0.1 0.1 -0.2 -0.3
Mood swings 1.1 1.9 2.6 -1.1 1.6
Loneliness, isolation 0.2 0.3 0.4 -0.6 -0.6
Long-standing illness, disability or infirmity 0.3 0.5 0.6 0.6 -0.8
Ever had bowel cancer screening 0.2 0.3 0.4 -0.6 0.4
Diabetes diagnosed by doctor 0.2 0.3 0.4 0.4 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 2.7 0.4 -1.6
Friendships satisfaction 0.5 0.7 1.0 -0.5 1.0
Qualifications: nursing, teaching 1.5 2.3 4.6 -0.3 -2.1
Commuting to job workplace: Walk 3.1 3.4 5.5 -2.4 1.1
Eye problems/disorders: Cataract 5.4 6.2 6.3 -2.5 2.5
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 1.0 -1.0 -0.9
Medication for cholesterol 0.1 0.1 0.2 0.4 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.0 0.0 -0.1 0.1
Back pain experienced in last month 0.1 0.1 0.2 -0.2 0.5
Mineral and other dietary supplements 0.0 0.1 0.1 -0.3 0.1
Breast cancer (self-reported) 0.2 0.2 0.3 -0.2 0.6
Asthma (self-reported) 0.3 0.6 0.7 0.7 -0.8
Osteoporosis (self-reported) 1.0 1.3 1.5 -1.1 1.2
Osteoarthritis (self-reported) 1.3 1.7 3.4 1.8 0.3
Medication: Aspirin 0.7 0.9 1.2 1.1 -0.8
Medication: Gliclazide 0.4 0.4 0.7 0.4 -0.8
Illnesses of father: None of the above (group 1) 0.3 0.4 0.8 0.2 0.9
Smoking status: Current 0.1 0.2 0.3 -0.2 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.1 6.5 9.3 1.9 -3.0
Whole body water mass 2.8 15.9 24.8 2.6 -5.0
Leg predicted mass (right) 2.5 13.5 19.8 2.7 -4.5
Arm fat mass (left) 0.2 0.9 1.7 1.3 -0.4
Number of self-reported non-cancer illnesses 0.5 0.8 1.4 -0.4 1.2
Average weekly champagne plus white wine intake 0.3 0.4 0.6 0.3 -0.8
Miserableness 2.5 4.2 4.2 -2.1 2.1
Guilty feelings 4.6 7.0 9.8 -3.1 2.0
Wears glasses or contact lenses 1.1 1.3 2.3 -1.5 0.5
Ever taken oral contraceptive pill 1.1 1.2 2.5 -1.6 0.1
Hearing aid user 0.0 0.0 0.0 -0.0 0.1
Mother’s age at death 0.6 0.8 1.6 -1.3 0.1
Financial situation satisfaction 0.7 0.9 1.3 1.1 -0.6
Tinnitus: Yes, now most or all of the time 2.5 2.9 4.4 -2.1 1.2
Commuting to job workplace: Public transport 0.0 0.1 0.1 0.2 -0.3
Eye problems/disorders: Glaucoma 1.3 1.6 1.8 -1.3 1.2
Medication: Blood pressure 0.0 0.0 0.1 0.2 -0.3
Pain type(s) experienced in last month: Hip pain 0.4 0.5 0.6 0.7 0.6
Supplements: Fish oil (including cod liver oil) 0.6 0.7 1.3 1.2 -0.3
High cholesterol (Self-reported) 0.5 0.8 1.5 0.4 1.2
Medication: Bendroflumethiazide 0.1 0.1 0.1 -0.3 -0.4
Medication: Paracetamol 0.8 1.2 1.8 1.3 -0.8
Medication: Lisinopril 0.2 0.3 0.5 0.1 -0.7
Medication: Atorvastatin 0.8 1.0 1.2 1.1 -0.8
Illnesses of father: High blood pressure 0.2 0.3 0.3 -0.6 -0.4
Alcohol drinker status: Never 1.4 1.7 2.2 1.5 -1.1
Ever smoked 0.1 0.1 0.2 -0.0 0.4
Basal metabolic rate 2.3 12.7 19.2 2.5 -4.4
Leg fat percentage (left) 0.4 1.4 2.2 0.8 1.5
Arm fat-free mass (left) 2.4 12.4 18.6 2.5 -4.3
Number of operations (self-reported) 2.1 3.1 5.3 -2.3 0.9
Average weekly beer plus cider intake 0.7 1.0 1.8 1.3 -0.4
Irritability 0.8 1.4 2.6 -1.6 0.5
Risk taking 0.7 1.1 2.0 0.4 -1.4
Ever had prostate specific antigen (PSA) test 0.5 0.5 0.9 -0.3 -1.0
Fractured/broken bones in last 5 years 0.2 0.2 0.5 0.7 0.1
Age started oral contraceptive pill 2.1 2.6 3.7 -1.9 1.2
Diastolic blood pressure, automated reading 1.0 3.1 4.6 1.3 -2.1
Ever depressed for a whole week 0.6 0.7 1.3 -0.5 1.1
Unable to work because of sickness or disability 3.5 4.5 5.9 1.8 -2.4
Commuting to job workplace: Cycle 2.1 2.6 4.5 0.8 -2.1
Myopia 0.3 0.4 0.8 0.9 0.0
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.1 -0.3 -0.3
Cholesterol lowering medication 0.7 1.1 2.1 -0.3 1.4
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 1.2 0.8 -1.1
Pain experienced in last month 0.0 0.0 0.0 -0.0 -0.1
Supplements: Calcium 0.1 0.2 0.2 -0.5 -0.3
Basal cell carcinoma (self-reported) 0.1 0.1 0.1 -0.3 -0.2
Heart attack/myocardial infarction (self-reported) 1.2 1.5 1.7 -1.3 1.1
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 2.9 -0.0 1.7
Heart disease (siblings) 5.6 6.9 8.8 -2.2 3.0
Alcohol drinker status: Previous 1.4 1.6 2.9 1.7 -0.5
Pack years of smoking 1.7 2.6 2.7 -1.6 1.6
Impedance of whole body 1.3 6.4 11.8 -1.0 3.4
Leg fat mass (left) 0.4 1.4 2.6 1.6 -0.4
Arm predicted mass (left) 2.7 13.7 21.3 2.5 -4.6