TWAS hub - GFAP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0487	0.0192	2.1e-05	0.044	0.039	0.037	0.042	0.047	3.2e-07	1.3e-06	2.4e-06	5.5e-07	1.2e-07
2	TCGA	Thyroid Carcinoma	0.0860	0.0450	2.9e-04	0.052	0.031	0.032	NA	0.045	7.4e-06	4.5e-04	4.0e-04	NA	3.4e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hand grip strength (left)	9.7	25.6	36.9	3.8	-6.1
Forced vital capacity (FVC), Best measure	7.5	27.3	34.1	4.5	-5.8
Hand grip strength (right)	6.3	17.1	24.3	3.1	-4.9
Hair/balding pattern: Pattern 2	6.1	7.7	9.9	-2.3	3.1
Eye problems/disorders: None of the above	6.1	7.0	8.0	2.8	-2.5
Forced vital capacity (FVC)	5.9	22.6	28.8	4.0	-5.4
Forced expiratory volume in 1-second (FEV1), Best measure	5.9	18.8	23.8	3.7	-4.9
Number of full brothers	5.8	7.3	9.8	-3.1	2.2
Heart disease (siblings)	5.6	6.9	8.8	-2.2	3.0
Eye problems/disorders: Cataract	5.4	6.2	6.3	-2.5	2.5
Ever unenthusiastic/disinterested for a whole week	5.2	6.3	6.8	-2.4	2.6
LDL Cholesterol	5.0	8.0	14.5	-1.2	3.8
Lung FVC	4.9	25.0	31.9	4.2	-5.7
Guilty feelings	4.6	7.0	9.8	-3.1	2.0
Forced expiratory volume in 1-second (FEV1)	4.2	14.2	17.9	3.2	-4.2
Alzheimer’s Disease (in mother)	4.1	4.8	6.7	1.7	-2.6
Diverticular disease/diverticulitis (self-reported)	4.0	4.7	7.9	1.2	-2.8
Unable to work because of sickness or disability	3.5	4.5	5.9	1.8	-2.4
Age when periods started (menarche)	3.3	7.9	8.6	-2.7	2.9
Sitting height	3.3	23.7	40.1	2.7	-6.3
Chronotype (morning person)	3.2	7.4	7.7	2.7	-2.8
Frequency of depressed mood in last 2 weeks	3.1	4.4	5.8	-2.4	1.7
Hair/balding pattern: Pattern 3	3.1	4.7	5.2	2.0	-2.3
Commuting to job workplace: Walk	3.1	3.4	5.5	-2.4	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.1	6.5	9.3	1.9	-3.0
Trunk fat-free mass	2.9	16.5	27.5	2.3	-5.2
Trunk predicted mass	2.9	16.5	27.7	2.3	-5.3
Whole body fat-free mass	2.9	16.4	25.8	2.6	-5.1
Comparative height size at age 10	2.8	15.5	15.7	3.9	-4.0
Whole body water mass	2.8	15.9	24.8	2.6	-5.0
Arm predicted mass (left)	2.7	13.7	21.3	2.5	-4.6
Leg fat-free mass (right)	2.6	13.7	20.0	2.7	-4.5
Leg predicted mass (right)	2.5	13.5	19.8	2.7	-4.5
Miserableness	2.5	4.2	4.2	-2.1	2.1
Tinnitus: Yes, now most or all of the time	2.5	2.9	4.4	-2.1	1.2
Arm fat-free mass (left)	2.4	12.4	18.6	2.5	-4.3
Leg fat-free mass (left)	2.3	12.3	17.8	2.6	-4.2
Leg predicted mass (left)	2.3	12.4	18.0	2.6	-4.2
Arm fat-free mass (right)	2.3	11.6	17.3	2.4	-4.2
Basal metabolic rate	2.3	12.7	19.2	2.5	-4.4
Heart disease (mother)	2.2	2.7	4.8	-2.2	0.8
Supplements: Vitamin C	2.2	2.6	3.3	-1.4	1.8
Alzheimer’s Disease (including proxy)	2.1	3.0	4.2	1.3	-2.0
HbA1C	2.1	2.4	3.7	-1.0	1.9
Financial difficulties in last 2 years	2.1	2.8	3.9	1.3	-2.0
Pulse wave peak to peak time	2.1	2.5	3.0	1.7	-1.4
Migraine (self-reported)	2.1	2.7	3.5	1.9	-1.3
Arm predicted mass (right)	2.1	10.5	16.1	2.2	-4.0
Number of operations (self-reported)	2.1	3.1	5.3	-2.3	0.9
Age started oral contraceptive pill	2.1	2.6	3.7	-1.9	1.2
Commuting to job workplace: Cycle	2.1	2.6	4.5	0.8	-2.1
Bipolar Disorder (2018)	1.9	3.1	4.4	-1.3	2.1
Height	1.9	36.0	53.0	4.4	-7.3
Age at first live birth	1.9	3.3	5.3	-1.2	-2.3
Age at last live birth	1.9	2.7	5.4	-0.1	-2.3
Bipolar Disorder (2011)	1.8	1.7	1.9	-1.2	1.4
Triglycerides	1.8	2.9	4.7	-1.0	2.2
Other serious medical condition/disability diagnosed by doctor	1.8	2.4	2.6	-1.6	1.5
Pain all over the body in last month	1.8	1.9	2.3	-1.3	1.5
Illnesses of siblings	1.8	2.5	3.1	1.7	-1.4
Father’s age at death	1.8	2.4	4.7	-2.2	-0.3
Depression (self-reported)	1.8	2.1	3.9	-2.0	0.6
Pulse wave Arterial Stiffness index	1.8	2.1	2.9	-1.7	1.2
Standing height	1.8	17.8	27.8	2.8	-5.3
Shortness of breath walking on level ground	1.8	2.1	3.4	-0.9	1.9
Irritable Bowel Disease (IBD)	1.7	4.0	4.8	1.8	-2.2
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	3.0	-0.9	1.7
Angina	1.7	2.2	3.6	-0.9	1.9
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	3.8	-1.9	1.3
Pack years of smoking	1.7	2.6	2.7	-1.6	1.6
Ulcerative Colitis (UC)	1.6	3.0	3.3	1.8	-1.7
Heart attack	1.6	2.0	2.0	-1.4	1.4
Loud music exposure frequency	1.6	1.8	2.2	-1.5	1.1
Worry too long after embarrassment	1.6	2.7	3.8	-1.9	1.3
Number of full sisters	1.6	1.9	2.9	1.7	-0.9
Neuroticism score	1.5	3.2	3.8	-1.9	1.6
Number of live births	1.5	2.1	4.2	2.0	0.1
Qualifications: nursing, teaching	1.5	2.3	4.6	-0.3	-2.1
Pack years adult smoking proportion	1.4	2.1	2.3	-1.5	1.4
Impedance of leg (right)	1.4	6.6	11.4	-1.4	3.4
Serious illness, injury or assault to yourself	1.4	1.6	3.3	-1.8	0.1
Fluid intelligence score	1.4	2.9	4.1	1.3	-2.0
Exposure to tobacco smoke at home	1.4	1.6	3.1	-0.4	1.8
Medication: Seretide 50 evohaler	1.4	1.6	2.3	0.9	-1.5
Alcohol drinker status: Never	1.4	1.7	2.2	1.5	-1.1
Alcohol drinker status: Previous	1.4	1.6	2.9	1.7	-0.5
Intelligence (Savage-Jansen 2018)	1.3	4.1	8.1	0.0	-2.8
Sensitivity / hurt feelings	1.3	2.3	3.6	-1.0	1.9
Blood clot in the leg (DVT)	1.3	1.7	3.4	-0.3	1.8
Birth weight	1.3	2.8	4.7	-2.2	1.0
Mean time to correctly identify matches	1.3	2.4	4.6	-0.4	2.1
Had major operations	1.3	1.5	2.3	-1.5	0.8
Average weekly red wine intake	1.3	2.0	2.0	1.4	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.7	0.4	-1.6
Osteoarthritis (self-reported)	1.3	1.7	3.4	1.8	0.3
Eye problems/disorders: Glaucoma	1.3	1.6	1.8	-1.3	1.2
Impedance of whole body	1.3	6.4	11.8	-1.0	3.4
Supplements: Zinc	1.2	1.3	2.0	-1.4	0.8
Townsend deprivation index at recruitment	1.2	1.8	3.4	-0.4	1.8
Impedance of leg (left)	1.2	5.6	10.5	-0.9	3.2
Had menopause	1.2	1.6	2.5	-1.6	0.8
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.5	-1.6	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.2	-1.5	1.0
Qualifications: College or University degree	1.2	3.8	7.2	0.6	-2.7
Heart attack/myocardial infarction (self-reported)	1.2	1.5	1.7	-1.3	1.1
Blood Platelet Count	1.1	12.4	20.8	-2.0	4.6
Weight	1.1	5.2	5.6	2.2	-2.4
Falls in the last year	1.1	1.4	1.7	-1.1	1.3
Angina (self-reported)	1.1	1.4	2.3	-0.8	1.5
Leg pain on walking	1.1	1.4	1.8	1.0	-1.4
Mood swings	1.1	1.9	2.6	-1.1	1.6
Wears glasses or contact lenses	1.1	1.3	2.3	-1.5	0.5
Ever taken oral contraceptive pill	1.1	1.2	2.5	-1.6	0.1
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.9	-0.0	1.7
Depression (Nagel 2018)	1.0	1.5	1.7	-1.3	1.1
Taking other prescription medications	1.0	1.5	2.5	1.6	-0.7
Mouth/teeth dental problems: Dentures	1.0	1.7	3.1	1.8	-0.4
Illnesses of mother	1.0	1.2	2.3	-0.2	1.5
Medication: Amlodipine	1.0	1.3	2.7	1.6	-0.0
Osteoporosis (self-reported)	1.0	1.3	1.5	-1.1	1.2
Diastolic blood pressure, automated reading	1.0	3.1	4.6	1.3	-2.1
Neuroticism (Nagel 2018)	0.9	2.1	2.5	-1.3	1.6
Schizophrenia vs Biploar Disorder	0.9	1.1	2.0	1.4	-0.5
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.8	0.6	-2.0
HDL Cholesterol	0.9	1.5	1.9	1.0	-1.4
Ulcerative Colitis	0.9	1.3	1.4	1.1	-1.2
Time employed in main current job	0.9	1.1	1.9	1.4	-0.5
Impedance of arm (left)	0.9	4.2	8.2	-0.6	2.9
Medication: Blood pressure	0.9	1.5	2.4	1.6	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	3.4	0.3	-1.9
Mean Putamen Volume	0.8	0.9	1.6	0.4	-1.3
Neuroticism	0.8	1.9	2.1	-1.4	1.3
Qualifications: None of the above	0.8	1.8	3.1	0.7	1.8
Emphysema/chronic bronchitis	0.8	1.0	1.2	-0.9	1.1
Medication for pain relief, constipation, heartburn	0.8	1.3	1.5	-1.2	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.2	0.9	-1.1
Medication: Paracetamol	0.8	1.2	1.8	1.3	-0.8
Medication: Atorvastatin	0.8	1.0	1.2	1.1	-0.8
Irritability	0.8	1.4	2.6	-1.6	0.5
Relative age of first facial hair	0.7	1.4	1.5	-1.2	1.1
Noisy workplace	0.7	0.8	1.4	1.2	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.3	-0.5	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.8	0.2	-1.4
Medication: Cholesterol lowering	0.7	1.1	2.1	-0.1	1.4
Lung cancer (father)	0.7	0.8	1.0	0.7	1.0
Hair/balding pattern: Pattern 4	0.7	1.6	2.7	1.6	-0.8
Wheeze or whistling in the chest in last year	0.7	1.2	2.0	1.4	-0.7
Medication: Aspirin	0.7	0.9	1.2	1.1	-0.8
Financial situation satisfaction	0.7	0.9	1.3	1.1	-0.6
Average weekly beer plus cider intake	0.7	1.0	1.8	1.3	-0.4
Risk taking	0.7	1.1	2.0	0.4	-1.4
Cholesterol lowering medication	0.7	1.1	2.1	-0.3	1.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.2	0.8	-1.1
Ovarian Cancer	0.6	0.7	1.4	-1.2	0.2
Ever had hysterectomy (womb removed)	0.6	0.7	1.2	1.1	-0.4
Severe depression (siblings)	0.6	0.7	0.9	-0.9	0.7
Current tobacco smoking	0.6	0.9	1.5	-0.5	1.2
Number of incorrect matches in round	0.6	1.1	2.0	0.3	1.4
Impedance of arm (right)	0.6	2.6	5.0	-0.5	2.2
Peak expiratory flow (PEF)	0.6	1.4	2.3	0.7	-1.5
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.3	-1.1	-0.7
Gout (self-reported)	0.6	0.9	1.6	0.3	1.3
Exposure to tobacco smoke outside home	0.6	0.9	1.0	-0.8	1.0
Medication: Omeprazole	0.6	0.7	0.9	0.7	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.0	-1.0	-0.9
Mother’s age at death	0.6	0.8	1.6	-1.3	0.1
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.3	1.2	-0.3
Ever depressed for a whole week	0.6	0.7	1.3	-0.5	1.1
Crohns Disease (2017)	0.5	1.2	1.9	0.7	-1.4
Breast Cancer	0.5	1.1	1.7	-1.3	0.8
Age at First Birth	0.5	0.7	1.3	-0.2	-1.1
Fasting Glucose	0.5	0.5	1.0	1.0	-0.2
Neuroticism (2016)	0.5	0.8	1.1	-1.1	0.7
Hearing difficulty/problems: Yes	0.5	0.7	1.4	-0.3	-1.2
Medication for hormone replacement therapy	0.5	0.5	0.7	-0.8	-0.6
Medication: Co-codamol	0.5	0.6	1.2	1.1	-0.1
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.8	0.4	-1.4
Chronic bronchitis/emphysema (father)	0.5	0.5	0.8	-0.9	0.5
Alcohol usually taken with meals	0.5	0.7	0.7	-0.9	-0.9
Diabetes (self-reported)	0.5	0.7	1.1	0.5	-1.1
Medication: Simvastatin	0.5	0.7	1.4	0.0	1.2
Worrier / anxious feelings	0.5	1.0	1.6	-0.7	1.3
Happiness	0.5	0.6	0.7	-0.8	0.8
Medication: Ibuprofen	0.5	0.6	1.2	0.2	-1.1
Medication: Allopurinol	0.5	0.7	1.3	-0.2	1.2
Medication: Aspirin	0.5	0.6	0.8	0.9	-0.7
Friendships satisfaction	0.5	0.7	1.0	-0.5	1.0
Number of self-reported non-cancer illnesses	0.5	0.8	1.4	-0.4	1.2
High cholesterol (Self-reported)	0.5	0.8	1.5	0.4	1.2
Ever had prostate specific antigen (PSA) test	0.5	0.5	0.9	-0.3	-1.0
Depressed Affect (Nagel 2018)	0.4	0.9	1.5	-0.5	1.2
Alzheimer’s Disease (in father)	0.4	0.4	0.8	0.3	-0.9
Reaction Time	0.4	0.7	1.1	0.6	1.0
Coronary Artery Disease (CAD)	0.4	0.5	0.6	0.6	-0.8
Crohns Disease (2012)	0.4	0.7	0.8	0.7	-0.9
Blood White Count	0.4	2.6	4.9	2.2	0.5
Waist Hip Ratio (WHR)	0.4	1.8	2.4	-1.1	1.6
Tanning	0.4	4.7	6.5	2.6	-1.7
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.8	-0.9	0.5
Diabetes (father)	0.4	0.5	1.0	0.3	-1.0
Trunk fat percentage	0.4	1.6	2.1	1.1	1.4
Average weekly fortified wine intake	0.4	0.5	0.7	-0.5	0.8
High blood pressure	0.4	1.0	1.2	1.1	-0.9
Nervous feelings	0.4	0.8	1.2	-0.6	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.1	-1.0	0.4
Medication: Ramipril	0.4	0.5	0.9	-0.9	-0.4
Pulse rate	0.4	0.8	1.2	-0.6	-1.1
Asthma	0.4	0.8	0.8	0.9	-0.9
Medication: Lansoprazole	0.4	0.5	0.9	-0.3	0.9
Birth weight of first child	0.4	0.8	1.3	0.5	-1.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.3	-1.1	-0.0
Headache pain in last month	0.4	0.6	0.7	-0.8	-0.7
Leg fat percentage (right)	0.4	1.5	3.0	0.3	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.6	-0.8	0.6
Medication: Gliclazide	0.4	0.4	0.7	0.4	-0.8
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.6	0.7	0.6
Leg fat percentage (left)	0.4	1.4	2.2	0.8	1.5
Leg fat mass (left)	0.4	1.4	2.6	1.6	-0.4
Bipolar Disorder or Schizophrenia	0.3	0.8	1.5	-0.2	1.2
Major Depression (MDD)	0.3	0.4	0.6	0.3	-0.8
Primary Biliary Cirrhosis	0.3	0.4	0.7	0.9	-0.2
Heel T-Score	0.3	2.5	4.7	-0.6	-2.2
BMI	0.3	1.5	2.9	1.7	-0.3
Type 2 Diabetes (T2D) (2018)	0.3	0.6	0.9	1.0	-0.6
Lung FEV1/FVC ratio	0.3	1.4	2.0	-1.0	1.4
Number of treatments/medications taken	0.3	0.6	1.1	1.0	-0.3
Fed-up feelings	0.3	0.5	0.8	-0.4	0.9
Relative age voice broke	0.3	0.5	1.1	1.0	-0.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.4	0.6	-0.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	-0.8	0.3
Trunk fat mass	0.3	1.3	2.6	1.6	-0.1
Hearing difficulty/problems with background noise	0.3	0.4	0.8	-0.9	0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	-0.9	-0.2
Alcohol intake versus 10 years previously	0.3	0.4	0.4	-0.6	0.7
Prospective memory result	0.3	0.4	0.7	-0.3	0.9
Arm fat mass (right)	0.3	1.2	2.3	1.5	-0.4
Breastfed as a baby	0.3	0.3	0.6	0.1	-0.8
Pulse wave reflection index	0.3	0.3	0.5	0.7	-0.4
Medication: Paracetamol	0.3	0.5	0.9	1.0	-0.0
Body fat percentage	0.3	1.4	2.1	0.8	1.5
Whole body fat mass	0.3	1.3	2.6	1.6	-0.3
Leg fat mass (right)	0.3	1.1	2.1	1.5	-0.2
Alcohol intake frequency.	0.3	0.6	0.6	0.8	-0.8
Knee pain experienced in last month	0.3	0.5	0.9	0.9	-0.2
Hypertension (Self-reported)	0.3	0.8	0.9	0.9	-0.9
Smoking status: Previous	0.3	0.4	0.8	0.9	-0.1
Arm fat percentage (left)	0.3	1.2	2.0	0.6	1.4
Long-standing illness, disability or infirmity	0.3	0.5	0.6	0.6	-0.8
Asthma (self-reported)	0.3	0.6	0.7	0.7	-0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	0.8	0.2	0.9
Average weekly champagne plus white wine intake	0.3	0.4	0.6	0.3	-0.8
Myopia	0.3	0.4	0.8	0.9	0.0
Worry (Nagel 2018)	0.2	0.4	0.7	-0.8	0.4
Schizophrenia (2014)	0.2	0.6	0.8	0.9	0.6
Blood Eosinophil Count	0.2	1.2	2.3	1.5	-0.3
Smoking Status	0.2	0.4	0.8	0.1	0.9
Allergy or Eczema	0.2	0.5	1.1	-0.0	-1.0
Cardiovascular Disease	0.2	0.5	1.0	1.0	0.2
Average weekly spirits intake	0.2	0.2	0.3	-0.5	0.4
Systolic blood pressure, automated reading	0.2	0.6	1.1	-0.4	1.0
Medication: Metformin	0.2	0.3	0.5	0.7	-0.2
Diabetes (mother)	0.2	0.2	0.4	0.7	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.4	-0.6	0.4
Allergy	0.2	0.4	0.8	-0.1	0.9
Arm fat percentage (right)	0.2	1.0	1.5	0.7	1.2
Length of working week for main job	0.2	0.3	0.4	0.6	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.5	-0.7	0.1
Glaucoma (self-reported)	0.2	0.2	0.3	-0.4	0.5
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	0.6	-0.2
High blood pressure (siblings)	0.2	0.3	0.6	-0.7	0.2
Number of children fathered	0.2	0.2	0.4	-0.7	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.4	0.4	0.6
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.2	0.4	0.5
Neck or shoulder pain in last month	0.2	0.3	0.4	0.3	-0.6
Pulse rate, automated reading	0.2	0.5	1.0	0.1	-1.0
Chest pain or discomfort	0.2	0.4	0.7	0.8	0.0
Family relationship satisfaction	0.2	0.2	0.4	0.2	0.6
Illnesses of siblings: Diabetes	0.2	0.2	0.2	-0.4	0.5
Loneliness, isolation	0.2	0.3	0.4	-0.6	-0.6
Ever had bowel cancer screening	0.2	0.3	0.4	-0.6	0.4
Diabetes diagnosed by doctor	0.2	0.3	0.4	0.4	-0.7
Breast cancer (self-reported)	0.2	0.2	0.3	-0.2	0.6
Arm fat mass (left)	0.2	0.9	1.7	1.3	-0.4
Medication: Lisinopril	0.2	0.3	0.5	0.1	-0.7
Illnesses of father: High blood pressure	0.2	0.3	0.3	-0.6	-0.4
Fractured/broken bones in last 5 years	0.2	0.2	0.5	0.7	0.1
Schizophrenia (2018)	0.1	0.3	0.6	0.8	-0.1
Prostate Cancer	0.1	0.2	0.4	-0.6	0.1
Lupus	0.1	0.2	0.3	0.3	-0.5
Rheumatoid Arthritis	0.1	0.2	0.3	0.1	-0.6
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.2	0.3	0.5
Blood Red Count	0.1	0.6	0.9	-0.5	-0.9
Vitamin and mineral supplements	0.1	0.2	0.3	0.6	-0.3
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.5	0.2
Multivitamins +/- minerals	0.1	0.2	0.3	0.1	-0.6
Supplements: Glucosamine	0.1	0.1	0.2	0.3	-0.5
Medication: Atenolol	0.1	0.1	0.2	0.1	0.4
Medication: Levothyroxine sodium	0.1	0.2	0.4	0.0	0.7
Body mass index (BMI)	0.1	0.5	1.0	1.0	-0.0
Past tobacco smoking	0.1	0.3	0.4	-0.4	-0.6
Had other major operations	0.1	0.1	0.3	-0.1	-0.5
Hip circumference	0.1	0.3	0.5	0.7	-0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	-0.2	-0.6
Tense / ‘highly strung’	0.1	0.2	0.2	-0.3	0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.2	0.4	0.4
Comparative body size at age 10	0.1	0.2	0.3	-0.6	-0.0
Suffer from ‘nerves’	0.1	0.2	0.4	0.6	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.2	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	0.2	0.3
Illnesses of father: Heart disease	0.1	0.2	0.2	-0.4	-0.4
Medication for cholesterol	0.1	0.1	0.2	0.4	0.1
Back pain experienced in last month	0.1	0.1	0.2	-0.2	0.5
Smoking status: Current	0.1	0.2	0.3	-0.2	0.6
Medication: Bendroflumethiazide	0.1	0.1	0.1	-0.3	-0.4
Ever smoked	0.1	0.1	0.2	-0.0	0.4
Supplements: Calcium	0.1	0.2	0.2	-0.5	-0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	-0.3	-0.2
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.1	-0.2
Systolic Blood Pressure	0.0	0.0	0.0	0.1	0.1
Hypothyroidism (self reported)	0.0	0.0	0.0	-0.1	0.1
Respiratory disease	0.0	0.0	0.0	0.2	-0.0
Hair Pigment	0.0	0.9	1.7	1.3	0.0
Maternal smoking around birth	0.0	0.0	0.1	-0.1	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.1	0.2	0.4
Stomach or abdominal pain in last month	0.0	0.1	0.1	-0.3	0.1
High blood pressure (mother)	0.0	0.0	0.1	0.0	-0.3
Waist circumference	0.0	0.2	0.3	0.2	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	0.1	0.4
Mouth/teeth dental problems	0.0	0.0	0.1	0.2	0.1
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	0.1	0.0
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	0.1	0.2
Health satisfaction	0.0	0.0	0.0	0.2	-0.1
Overall health rating	0.0	0.0	0.1	0.2	0.2
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	-0.1	-0.1
Handedness (chirality/laterality): Left-handed	0.0	0.1	0.1	-0.2	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	-0.1	0.1
Mineral and other dietary supplements	0.0	0.1	0.1	-0.3	0.1
Hearing aid user	0.0	0.0	0.0	-0.0	0.1
Commuting to job workplace: Public transport	0.0	0.1	0.1	0.2	-0.3
Medication: Blood pressure	0.0	0.0	0.1	0.2	-0.3
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.1	-0.3	-0.3
Pain experienced in last month	0.0	0.0	0.0	-0.0	-0.1

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