Best TWAS P=1.1e-18 · Best GWAS P=4.61e-15 conditioned to 0.371
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ATP6V0D1 | 0.10 | 0.12 | lasso | 8 | 0.11 | 2.4e-13 | -7.0 | 7.9 | 1.9e-15 | -0.84 | 0.07 | 0.93 | FALSE |
2 | GTEx | Adipose Subcutaneous | RANBP10 | 0.05 | 0.01 | lasso | 6 | 0.01 | 3.5e-02 | -6.2 | 7.1 | 1.7e-12 | -0.80 | 0.24 | 0.63 | FALSE |
3 | GTEx | Adipose Subcutaneous | C16orf86 | 0.11 | 0.04 | enet | 15 | 0.04 | 5.6e-04 | -6.1 | 5.5 | 3.7e-08 | -0.55 | 0.26 | 0.13 | FALSE |
4 | GTEx | Adipose Visceral Omentum | C16orf86 | 0.10 | 0.00 | enet | 20 | 0.00 | 1.7e-01 | -6.5 | 6.9 | 5.9e-12 | -0.60 | 0.10 | 0.08 | FALSE |
5 | GTEx | Artery Aorta | RANBP10 | 0.11 | 0.01 | enet | 11 | 0.04 | 2.0e-03 | 4.4 | 6.4 | 2.0e-10 | -0.47 | 0.10 | 0.17 | FALSE |
6 | GTEx | Artery Tibial | RANBP10 | 0.08 | 0.04 | lasso | 3 | 0.05 | 6.4e-05 | -7.6 | 7.2 | 6.5e-13 | -0.93 | 0.04 | 0.95 | FALSE |
7 | GTEx | Brain Nucleus accumbens basal ganglia | CTCF | 0.11 | 0.03 | lasso | 5 | 0.04 | 2.4e-02 | -6.3 | -6.0 | 2.1e-09 | 0.73 | 0.08 | 0.41 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | RANBP10 | 0.10 | 0.01 | enet | 29 | 0.03 | 2.8e-03 | -5.7 | 5.2 | 1.6e-07 | -0.63 | 0.05 | 0.27 | FALSE |
9 | GTEx | Esophagus Muscularis | RANBP10 | 0.13 | 0.05 | lasso | 4 | 0.02 | 2.3e-02 | -7.7 | 7.5 | 8.9e-14 | -0.90 | 0.04 | 0.93 | FALSE |
10 | GTEx | Muscle Skeletal | C16orf86 | 0.05 | 0.04 | lasso | 2 | 0.03 | 4.0e-04 | -6.1 | 6.4 | 1.5e-10 | -0.83 | 0.07 | 0.71 | FALSE |
11 | GTEx | Nerve Tibial | RANBP10 | 0.15 | 0.14 | lasso | 7 | 0.13 | 1.8e-09 | -5.9 | 6.9 | 4.7e-12 | -0.90 | 0.18 | 0.82 | FALSE |
12 | GTEx | Pituitary | ZDHHC1 | 0.23 | 0.13 | lasso | 4 | 0.08 | 4.0e-03 | -6.1 | -5.7 | 1.5e-08 | 0.75 | 0.05 | 0.44 | FALSE |
13 | GTEx | Skin Not Sun Exposed Suprapubic | CTRL | 0.13 | 0.04 | lasso | 9 | 0.08 | 2.7e-05 | -6.2 | -6.1 | 1.1e-09 | 0.67 | 0.61 | 0.26 | FALSE |
14 | GTEx | Skin Not Sun Exposed Suprapubic | ZDHHC1 | 0.10 | 0.00 | lasso | 7 | 0.00 | 5.1e-01 | -7.7 | 5.8 | 6.8e-09 | -0.86 | 0.02 | 0.73 | FALSE |
15 | GTEx | Spleen | ATP6V0D1 | 0.36 | 0.03 | enet | 9 | 0.07 | 6.0e-03 | -4.9 | 8.3 | 1.3e-16 | -0.83 | 0.03 | 0.37 | FALSE |
16 | GTEx | Thyroid | RANBP10 | 0.08 | 0.03 | lasso | 4 | 0.03 | 2.2e-03 | -6.5 | 7.0 | 1.9e-12 | -0.87 | 0.09 | 0.68 | FALSE |
17 | GTEx | Thyroid | ZDHHC1 | 0.07 | 0.03 | lasso | 6 | 0.02 | 1.6e-02 | -7.8 | -7.8 | 8.1e-15 | 1.00 | 0.02 | 0.96 | FALSE |
18 | GTEx | Thyroid | HSD11B2 | 0.15 | 0.07 | enet | 23 | 0.09 | 1.9e-07 | -6.6 | -7.0 | 3.4e-12 | 0.88 | 0.25 | 0.75 | FALSE |
19 | GTEx | Whole Blood | ATP6V0D1 | 0.08 | 0.00 | enet | 13 | 0.00 | 3.6e-01 | -7.0 | 7.9 | 2.2e-15 | -0.84 | 0.03 | 0.86 | FALSE |
20 | GTEx | Whole Blood | DUS2 | 0.12 | 0.04 | enet | 10 | 0.05 | 4.0e-05 | -6.1 | -6.4 | 1.4e-10 | 0.76 | 0.89 | 0.10 | FALSE |
21 | METSIM | Adipose | ATP6V0D1 | 0.13 | 0.03 | bslmm | 210 | 0.07 | 3.5e-11 | -7.0 | 6.1 | 1.0e-09 | -0.63 | 0.05 | 0.95 | FALSE |
22 | METSIM | Adipose | CTCF | 0.03 | 0.02 | bslmm | 222 | 0.01 | 3.4e-03 | -7.6 | -8.8 | 1.1e-18 | 0.91 | 0.02 | 0.91 | TRUE |
23 | METSIM | Adipose | LRRC36 | 0.10 | 0.07 | lasso | 24 | 0.10 | 1.6e-14 | -7.6 | -7.4 | 1.6e-13 | 0.95 | 0.02 | 0.98 | FALSE |
24 | METSIM | Adipose | RLTPR | 0.04 | 0.00 | bslmm | 211 | 0.00 | 1.1e-01 | -7.6 | -5.4 | 6.9e-08 | 0.84 | 0.03 | 0.80 | TRUE |
25 | NTR | Blood | ATP6V0D1 | 0.02 | 0.01 | bslmm | 220 | 0.01 | 1.6e-04 | -7.0 | 8.0 | 9.8e-16 | -0.75 | 0.14 | 0.74 | FALSE |
26 | YFS | Blood | ATP6V0D1 | 0.14 | 0.18 | lasso | 15 | 0.20 | 1.8e-63 | -7.5 | 7.7 | 1.0e-14 | -0.93 | 0.02 | 0.98 | FALSE |
27 | YFS | Blood | ZDHHC1 | 0.05 | 0.05 | enet | 26 | 0.05 | 1.8e-16 | -7.8 | -7.5 | 6.3e-14 | 0.86 | 0.02 | 0.98 | FALSE |
28 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ATP6V0D1 | 0.01 | 0.01 | blup | 33 | 0.01 | 7.1e-03 | -7.0 | 7.1 | 1.1e-12 | -0.67 | 0.02 | 0.18 | FALSE |
29 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZDHHC1 | 0.02 | 0.01 | lasso | 1 | 0.01 | 2.4e-03 | -7.7 | 7.7 | 1.5e-14 | -1.00 | 0.01 | 0.84 | FALSE |
30 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | C16orf86 | 0.09 | 0.00 | enet | 9 | 0.06 | 1.0e-03 | -5.5 | 5.2 | 1.9e-07 | -0.48 | 0.00 | 0.33 | FALSE |
31 | The Cancer Genome Atlas | Colon Adenocarcinoma | CENPT | 0.05 | 0.05 | enet | 8 | 0.04 | 3.0e-03 | -6.5 | -6.3 | 2.9e-10 | 0.72 | 0.01 | 0.91 | FALSE |
32 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GFOD2 | 0.03 | 0.03 | lasso | 1 | 0.03 | 3.6e-04 | -6.5 | 6.5 | 8.9e-11 | -0.77 | 0.00 | 0.99 | FALSE |
33 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ATP6V0D1 | 0.04 | 0.06 | lasso | 4 | 0.05 | 1.4e-06 | -7.0 | 7.3 | 3.9e-13 | -0.72 | 0.22 | 0.77 | FALSE |
34 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TPPP3 | 0.03 | 0.02 | blup | 31 | 0.04 | 2.1e-05 | -7.5 | 6.9 | 5.6e-12 | -0.93 | 0.02 | 0.97 | FALSE |
35 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RANBP10 | 0.04 | 0.03 | blup | 31 | 0.04 | 6.5e-05 | -6.2 | 6.3 | 2.6e-10 | -0.75 | 0.02 | 0.95 | FALSE |
36 | The Cancer Genome Atlas | Lung Adenocarcinoma | ATP6V0D1 | 0.04 | 0.02 | blup | 33 | 0.03 | 4.7e-04 | -7.0 | 8.3 | 7.5e-17 | -0.88 | 0.02 | 0.97 | FALSE |
37 | The Cancer Genome Atlas | Lung Adenocarcinoma | C16orf86 | 0.04 | 0.04 | lasso | 2 | 0.03 | 3.8e-04 | -6.3 | 6.4 | 1.5e-10 | -0.81 | 0.00 | 0.97 | FALSE |
38 | The Cancer Genome Atlas | Lung Adenocarcinoma | RLTPR | 0.03 | 0.02 | lasso | 3 | 0.02 | 1.8e-03 | -5.5 | 6.1 | 1.1e-09 | -0.80 | 0.00 | 0.90 | FALSE |
39 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ATP6V0D1 | 0.04 | 0.00 | enet | 6 | 0.00 | 9.3e-02 | -7.0 | 7.4 | 9.9e-14 | -0.70 | 0.01 | 0.51 | FALSE |
40 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | AGRP | 0.11 | 0.01 | enet | 6 | 0.07 | 2.5e-05 | 1.1 | -5.2 | 1.6e-07 | 0.65 | 0.01 | 0.61 | FALSE |
41 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C16orf86 | 0.05 | 0.05 | lasso | 1 | 0.04 | 2.9e-05 | -6.3 | 6.3 | 2.3e-10 | -0.81 | 0.00 | 0.99 | FALSE |
42 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CENPT | 0.02 | 0.01 | blup | 33 | 0.01 | 6.9e-02 | -6.5 | -6.3 | 3.4e-10 | 0.73 | 0.01 | 0.82 | FALSE |
43 | The Cancer Genome Atlas | Rectum Adenocarcinoma | LRRC36 | 0.13 | 0.12 | lasso | 14 | 0.11 | 1.4e-03 | -7.6 | -7.6 | 2.9e-14 | 0.99 | 0.01 | 0.67 | FALSE |
44 | The Cancer Genome Atlas | Stomach Adenocarcinoma | AGRP | 0.04 | 0.02 | blup | 23 | 0.03 | 3.0e-03 | -7.7 | -6.1 | 1.3e-09 | 0.88 | 0.01 | 0.74 | FALSE |
45 | The Cancer Genome Atlas | Thyroid Carcinoma | C16orf48 | 0.04 | 0.02 | blup | 17 | 0.04 | 8.5e-05 | -6.3 | 6.0 | 2.0e-09 | -0.70 | 0.00 | 0.76 | FALSE |
46 | The Cancer Genome Atlas | Thyroid Carcinoma | C16orf86 | 0.03 | 0.02 | blup | 17 | 0.03 | 5.3e-04 | -3.6 | 6.3 | 3.8e-10 | -0.70 | 0.01 | 0.95 | FALSE |
47 | The Cancer Genome Atlas | Thyroid Carcinoma | LRRC36 | 0.04 | 0.04 | lasso | 3 | 0.04 | 1.5e-04 | -7.8 | -7.8 | 5.2e-15 | 1.00 | 0.01 | 0.98 | FALSE |
48 | The Cancer Genome Atlas | Thyroid Carcinoma | ZDHHC1 | 0.07 | 0.06 | enet | 7 | 0.07 | 2.9e-07 | -7.8 | -7.0 | 2.5e-12 | 0.97 | 0.02 | 0.98 | FALSE |