TWAS hub - CTRL

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.330	0.112	2.2e-03	-0.003	NA	-0.002	NA	-0.003	0.7400	NA	6.1e-01	NA	9.5e-01
2	GTEx	Adipose Visceral Omentum	0.358	0.089	3.6e-03	0.002	NA	0.018	NA	0.001	0.2500	NA	3.7e-02	NA	2.8e-01
3	GTEx	Brain Hypothalamus	0.135	0.080	9.2e-03	-0.012	NA	-0.008	NA	-0.007	0.8700	NA	5.4e-01	NA	5.1e-01
4	GTEx	Skin Not Sun Exposed Suprapubic	0.134	0.053	8.3e-06	0.040	NA	0.083	NA	0.083	0.0028	NA	2.7e-05	NA	2.7e-05
5	GTEx	Skin Sun Exposed Lower leg	0.054	0.029	2.1e-04	0.021	NA	0.029	NA	0.020	0.0063	NA	1.9e-03	NA	7.9e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	3	4	5
HDL Cholesterol	29.8	49.7	125.4	8.8	6.7	11.2
Lung FEV1/FVC ratio	9.7	49.3	120.1	8.4	11.0	7.5
Medication: Seretide 50 evohaler	8.0	9.3	20.0	-3.7	-3.6	-4.5
Blood Red Count	6.7	64.5	114.5	9.9	10.7	10.5
Ovarian Cancer	6.2	8.2	14.6	-3.7	-3.6	-3.8
Hypothyroidism (self reported)	5.3	12.1	35.8	2.6	6.0	4.3
Fasting Glucose	5.1	6.2	12.4	-3.1	-3.5	-3.0
Hypothyroidism/myxoedema (self-reported)	4.2	8.3	23.6	2.2	4.9	3.6
Bipolar Disorder or Schizophrenia	3.9	9.4	23.5	3.1	4.8	3.8
Schizophrenia (2014)	3.8	8.4	16.2	3.4	3.8	4.0
Hair/balding pattern: Pattern 4	3.8	9.2	37.1	-0.0	-6.1	-3.0
Bipolar Disorder (2011)	3.7	3.6	9.5	2.3	3.1	1.8
Deep venous thrombosis (DVT) (self-reported)	3.7	4.8	11.0	2.9	2.1	3.3
Schizophrenia (2018)	3.4	7.1	16.0	2.6	4.0	3.5
Birth weight	3.3	7.1	14.2	-3.8	-3.2	-3.3
Emphysema/chronic bronchitis	3.3	3.7	9.2	-3.0	-2.4	-1.9
Blood clot in the leg (DVT)	3.1	4.0	9.7	2.7	1.8	3.1
Average weekly spirits intake	3.0	3.7	7.4	-2.7	-2.4	-2.3
Falls in the last year	2.6	3.5	7.7	-2.3	-2.8	-2.2
Medication: Levothyroxine sodium	2.5	4.2	15.2	1.2	3.9	2.0
Schizophrenia vs Biploar Disorder	2.3	3.0	10.6	3.3	1.3	1.7
Fluid intelligence score	2.3	4.9	10.6	-2.1	-3.0	-3.3
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	6.0	2.4	1.4	2.2
Pulse wave peak to peak time	2.2	2.6	6.4	-2.1	-1.5	-2.5
Average weekly champagne plus white wine intake	2.2	3.0	7.2	2.7	2.0	1.9
Myopia	2.2	3.2	11.8	1.6	3.4	1.2
Qualifications: CSEs or equivalent	2.1	2.7	7.9	0.9	2.8	2.2
Prospective memory result	2.1	2.6	5.6	2.4	1.9	2.0
Primary Biliary Cirrhosis	2.0	2.9	6.8	2.5	1.0	2.6
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	8.3	1.7	2.1	2.9
Intelligence (Savage-Jansen 2018)	1.9	5.8	14.2	-2.3	-3.1	-3.8
Waist Hip Ratio (WHR)	1.9	8.4	29.0	-2.3	-5.4	-2.8
Forced vital capacity (FVC)	1.9	7.2	20.1	-1.8	-4.5	-3.6
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	6.2	-1.7	-2.5	-1.4
Pulse wave Arterial Stiffness index	1.9	2.3	5.4	2.3	0.8	2.3
Suffer from ‘nerves’	1.9	3.0	8.9	-0.3	2.5	3.0
Irritability	1.9	3.2	6.7	2.0	2.3	2.6
Alcohol usually taken with meals	1.8	3.0	8.8	1.9	3.0	1.6
Prostate Cancer	1.7	2.4	5.1	-2.2	-2.1	-1.7
Stomach or abdominal pain in last month	1.7	2.1	5.5	1.6	1.5	2.4
Comparative body size at age 10	1.7	4.7	22.3	4.7	0.2	1.1
Chest pain or discomfort	1.7	2.5	9.3	-3.1	-1.5	-1.0
Bipolar Disorder (2018)	1.6	2.5	7.4	1.6	2.7	1.6
Serious illness, injury or assault to yourself	1.6	2.0	6.8	-1.1	-2.6	-1.3
Illnesses of father: High blood pressure	1.6	2.0	4.3	1.3	1.9	2.1
Basal cell carcinoma (self-reported)	1.6	1.9	4.9	-1.6	-1.3	-2.2
Number of full brothers	1.5	1.9	3.9	-1.8	-1.6	-2.0
Pain type(s) experienced in last month: Hip pain	1.5	1.8	4.0	1.3	2.0	1.9
Lupus	1.4	2.1	6.0	1.6	1.4	2.4
Chronotype (morning person)	1.4	3.1	9.2	-0.5	-3.0	-2.5
Forced vital capacity (FVC), Best measure	1.4	5.0	13.1	-1.5	-3.6	-3.1
Mood swings	1.4	2.6	5.4	1.8	2.1	2.3
Allergy or Eczema	1.3	3.5	8.5	-2.9	-1.3	-2.7
Neck or shoulder pain in last month	1.3	1.9	3.5	1.7	1.7	1.9
Migraine (self-reported)	1.3	1.6	5.1	2.3	1.3	1.0
Osteoporosis (self-reported)	1.3	1.6	4.2	-1.6	-1.1	-2.1
Heart attack/myocardial infarction (self-reported)	1.3	1.6	5.3	0.8	1.5	2.3
Verbal and Numeric Reasoning (VNR)	1.2	2.9	5.9	-1.9	-2.2	-2.4
Lung FVC	1.2	6.3	12.8	-3.0	-3.1	-3.6
Supplements: Zinc	1.2	1.3	3.3	0.9	1.8	1.5
Diabetes (father)	1.2	1.4	3.4	1.9	0.6	1.8
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	5.3	-2.3	-1.3	-1.1
Qualifications: College or University degree	1.2	3.8	10.1	-0.2	-3.2	-3.0
Asthma (self-reported)	1.2	2.4	5.9	-2.3	-1.1	-2.4
Number of operations (self-reported)	1.2	1.7	6.5	1.1	1.0	2.5
Breast Cancer	1.1	2.6	5.3	-2.2	-1.8	-2.3
Diabetes (mother)	1.1	1.4	6.3	0.0	0.8	2.5
Supplements: Glucosamine	1.1	1.5	5.2	-1.1	-2.3	-0.9
Medication: Atenolol	1.1	1.4	3.8	1.9	-0.3	1.8
Had other major operations	1.1	1.4	3.4	1.0	1.6	1.8
Medication: Lisinopril	1.1	1.4	3.8	0.2	-1.9	-1.7
Pain experienced in last month	1.1	1.8	4.7	-2.2	-1.1	-1.8
Worry (Nagel 2018)	1.0	2.1	6.6	-0.1	2.0	2.6
Coronary Artery Disease (CAD)	1.0	1.2	4.1	-0.8	-1.2	-2.0
Medication: Co-codamol	1.0	1.2	2.0	1.4	1.4	1.4
Multivitamins +/- minerals	1.0	1.3	2.7	1.1	1.5	1.6
Nervous feelings	1.0	1.9	4.5	-0.9	2.1	2.1
Time employed in main current job	1.0	1.2	2.6	-0.8	1.6	1.6
Alcohol intake versus 10 years previously	1.0	1.5	6.4	0.3	-2.5	-0.9
Asthma	1.0	2.0	5.0	-2.2	-0.8	-2.1
Standing height	1.0	9.4	35.9	2.3	-6.0	-2.5
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	5.1	2.3	1.0	0.8
Eye problems/disorders: None of the above	1.0	1.2	3.2	-1.1	-1.2	-1.8
Average weekly red wine intake	1.0	1.5	4.9	-1.6	-0.4	-2.2
Medication: Blood pressure	1.0	1.9	5.1	2.3	0.4	2.0
Neuroticism (2016)	0.9	1.2	2.9	0.6	1.7	1.7
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	4.0	0.3	1.3	2.0
Heart attack	0.9	1.2	3.8	0.5	1.4	1.9
Father’s age at death	0.9	1.2	2.7	1.6	1.3	1.3
Happiness	0.9	1.0	3.0	0.4	-1.7	-1.4
Comparative height size at age 10	0.9	5.2	18.0	2.7	-4.2	-0.8
Eye problems/disorders: Cataract	0.9	1.0	2.2	1.0	1.4	1.5
Osteoarthritis (self-reported)	0.9	1.1	2.5	1.2	1.3	1.6
Crohns Disease (2017)	0.8	1.7	4.1	-1.6	-2.0	-1.3
Respiratory disease	0.8	1.7	4.3	-2.1	-1.0	-1.8
Number of live births	0.8	1.1	2.9	1.7	1.2	1.0
Medication: Cholesterol lowering	0.8	1.3	4.2	0.3	1.4	2.1
Wheeze or whistling in the chest in last year	0.8	1.5	5.2	-2.3	-0.8	-1.3
Smoking status: Previous	0.8	1.2	4.6	-0.4	2.1	1.1
Medication for cholesterol	0.8	1.2	4.4	-2.1	0.4	-1.2
Hearing aid user	0.8	0.8	2.3	-1.0	-0.9	-1.5
Mother’s age at death	0.8	1.0	2.9	1.7	0.6	1.2
High cholesterol (Self-reported)	0.8	1.5	3.2	1.5	1.4	1.8
Ever smoked	0.8	1.3	3.2	1.1	1.8	1.5
Average weekly beer plus cider intake	0.8	1.2	3.1	-1.8	-1.5	-0.8
Ever depressed for a whole week	0.8	1.0	3.9	1.0	0.5	2.0
Neuroticism (Nagel 2018)	0.7	1.7	4.8	0.6	1.9	2.2
Alzheimer’s Disease (in father)	0.7	0.7	3.1	-0.0	1.8	0.7
Height	0.7	13.1	41.0	3.4	-6.4	-3.6
Neuroticism	0.7	1.8	4.5	0.6	2.0	2.1
Number of treatments/medications taken	0.7	1.2	3.5	1.5	0.5	1.9
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.1	0.7	1.2	1.8
Hearing difficulty/problems: Yes	0.7	1.0	4.6	-2.1	-0.2	-0.8
Pack years adult smoking proportion	0.7	1.1	3.4	-0.8	-1.8	-1.2
Trunk fat percentage	0.7	2.8	9.6	3.1	-0.3	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.5	-0.4	0.9	1.9
High blood pressure (mother)	0.7	1.0	4.0	-0.4	0.9	2.0
Trunk fat mass	0.7	2.9	11.2	3.3	-1.4	1.1
Waist circumference	0.7	2.5	9.3	1.2	-3.0	-1.2
Medication: Simvastatin	0.7	1.0	3.8	1.1	-0.0	2.0
Neuroticism score	0.7	1.4	4.3	-0.3	1.7	2.1
Trunk fat-free mass	0.7	3.9	10.8	1.7	-3.3	-2.5
Hair/balding pattern: Pattern 3	0.7	1.1	3.7	-1.2	0.4	-1.9
Illnesses of mother	0.7	0.8	3.8	-0.6	-0.3	-1.9
Trunk predicted mass	0.7	4.0	11.2	1.6	-3.3	-2.5
Shortness of breath walking on level ground	0.7	0.8	2.0	-1.4	-1.3	-0.6
Alcohol intake frequency.	0.7	1.7	4.1	0.8	2.0	2.0
Family relationship satisfaction	0.7	0.8	3.1	0.3	-1.8	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.0	0.8	-1.4	-1.2
Supplements: Vitamin C	0.7	0.8	2.1	0.7	1.5	1.2
Back pain experienced in last month	0.7	1.0	3.4	1.2	0.4	1.9
Medication: Aspirin	0.7	0.9	3.1	1.1	0.4	1.8
Pack years of smoking	0.7	1.0	3.6	-0.6	-1.9	-1.0
Vitamin and mineral supplements	0.6	0.8	2.3	-0.8	-1.5	-1.0
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.8	-1.9	0.2	-1.6
Qualifications: A levels/AS levels or equivalent	0.6	1.4	4.3	-0.6	-1.5	-2.1
Tense / ‘highly strung’	0.6	1.0	3.6	0.6	0.9	1.9
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.5	0.5	-0.9	1.6
Body fat percentage	0.6	2.3	8.4	2.9	-0.3	1.8
Heart disease (mother)	0.6	0.7	2.7	1.7	0.2	0.8
Whole body fat mass	0.6	2.6	11.0	3.3	-1.0	1.1
Number of full sisters	0.6	0.7	2.4	-1.0	-1.5	-0.5
Had major operations	0.6	0.8	2.8	-0.8	-1.7	-0.7
Loneliness, isolation	0.6	0.8	2.1	0.5	1.2	1.4
Qualifications: nursing, teaching	0.6	0.9	2.6	0.9	1.6	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.4	-1.1	-1.0	-1.2
Medication: Gliclazide	0.6	0.7	2.9	0.4	1.7	0.8
Arm fat-free mass (left)	0.6	2.9	6.8	2.2	-2.6	-1.7
Alcohol drinker status: Previous	0.6	0.6	2.1	0.5	0.9	1.5
Leg fat mass (left)	0.6	2.4	10.4	3.2	-1.0	0.7
Depression (Nagel 2018)	0.5	0.8	3.0	0.4	0.9	1.7
Age at First Birth	0.5	0.7	2.5	-0.8	-0.7	-1.6
Crohns Disease (2012)	0.5	0.8	2.9	-0.7	-1.7	-0.7
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.4	-0.8	-1.2	-0.8
Heel T-Score	0.5	4.3	18.6	0.7	4.3	1.6
Current tobacco smoking	0.5	0.8	2.0	1.2	-1.4	-0.8
Weight	0.5	2.4	6.7	2.6	-2.2	-0.6
Arm fat percentage (right)	0.5	1.9	7.5	2.7	0.5	1.4
Arm fat mass (right)	0.5	2.1	9.7	3.1	-0.6	0.8
Peak expiratory flow (PEF)	0.5	1.1	3.5	1.9	1.1	0.8
Headache pain in last month	0.5	0.9	3.4	1.8	0.8	0.5
Gout (self-reported)	0.5	0.7	2.5	-1.6	1.0	0.1
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.3	-1.5	0.2	-1.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.9	-0.8	1.4	0.6
Medication: Blood pressure	0.5	0.9	2.5	-0.5	-1.4	-1.6
Leg fat mass (right)	0.5	2.0	8.4	2.9	-1.3	0.4
Arm predicted mass (right)	0.5	2.4	5.3	2.1	-2.3	-1.5
Leg pain on walking	0.5	0.6	2.0	-0.7	-1.4	-0.7
Knee pain experienced in last month	0.5	0.8	1.8	1.1	0.9	1.3
Whole body fat-free mass	0.5	2.6	6.7	1.8	-2.6	-1.8
Arm fat percentage (left)	0.5	1.9	7.1	2.7	0.3	1.5
Smoking status: Current	0.5	0.7	1.7	1.1	-1.3	-0.9
Arm fat mass (left)	0.5	2.1	9.4	3.1	-0.7	0.8
Ever taken oral contraceptive pill	0.5	0.5	2.5	-1.6	0.1	0.2
Medication: Bendroflumethiazide	0.5	0.7	2.3	1.0	-1.5	-0.6
Basal metabolic rate	0.5	2.7	7.1	2.0	-2.7	-1.6
Leg fat percentage (left)	0.5	1.6	6.4	2.5	-0.3	1.3
Diastolic blood pressure, automated reading	0.5	1.6	6.6	2.6	0.8	0.9
Arm predicted mass (left)	0.5	2.8	6.8	2.2	-2.6	-1.6
Ulcerative Colitis (UC)	0.4	0.8	3.2	0.6	0.5	1.8
Mean Putamen Volume	0.4	0.4	1.5	-1.2	0.8	-0.1
Triglycerides	0.4	0.7	2.1	-0.8	-0.8	-1.5
Sensitivity / hurt feelings	0.4	0.7	2.6	0.7	-0.4	1.6
Townsend deprivation index at recruitment	0.4	0.6	2.5	-1.6	-0.4	-0.5
Hair/balding pattern: Pattern 2	0.4	0.6	1.9	1.4	0.4	0.9
Financial difficulties in last 2 years	0.4	0.5	2.2	1.5	-0.4	0.1
Medication: Lansoprazole	0.4	0.5	2.0	1.4	0.2	0.5
Pulse wave reflection index	0.4	0.5	1.4	0.6	0.8	1.2
Arm fat-free mass (right)	0.4	2.3	6.0	1.7	-2.5	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	2.1	-0.2	1.4	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.3	-0.6	-1.2	-0.9
Illnesses of siblings: Diabetes	0.4	0.5	2.4	-1.6	-0.0	-0.2
Friendships satisfaction	0.4	0.5	1.5	0.2	-1.0	-1.2
Whole body water mass	0.4	2.4	5.7	1.9	-2.4	-1.7
Financial situation satisfaction	0.4	0.5	2.0	-0.4	-1.4	-0.4
Commuting to job workplace: Public transport	0.4	0.5	1.2	-0.2	-1.1	-1.1
Cholesterol lowering medication	0.4	0.6	2.0	1.4	-0.1	1.1
Major Depression (MDD)	0.3	0.3	0.9	0.7	0.9	0.5
Rheumatoid Arthritis	0.3	0.3	1.2	-1.1	-0.3	-0.7
Blood White Count	0.3	2.2	8.4	-0.5	-2.9	-1.6
BMI	0.3	1.8	6.5	2.5	1.3	1.1
Hair Pigment	0.3	7.8	18.4	2.5	4.3	3.8
Ever had hysterectomy (womb removed)	0.3	0.3	1.7	1.3	0.1	0.0
Leg fat-free mass (left)	0.3	1.3	3.1	1.6	-1.8	-1.1
Average weekly fortified wine intake	0.3	0.3	1.4	-0.5	0.0	-1.2
Taking other prescription medications	0.3	0.5	1.9	-0.3	0.7	1.4
Leg predicted mass (left)	0.3	1.3	3.2	1.6	-1.8	-1.1
Allergy	0.3	0.7	2.5	1.6	-0.6	0.9
Illnesses of siblings	0.3	0.4	1.0	0.7	1.0	0.6
Mouth/teeth dental problems: Dentures	0.3	0.5	2.7	-1.6	-0.2	0.1
Lung cancer (father)	0.3	0.4	1.2	0.7	1.1	0.5
Birth weight of first child	0.3	0.6	2.5	-1.6	0.6	-0.4
Medication: Amlodipine	0.3	0.4	1.3	-1.1	0.9	0.0
Leg fat percentage (right)	0.3	1.0	3.9	2.0	-0.7	0.7
Worry too long after embarrassment	0.3	0.4	1.4	-0.3	0.8	1.2
Number of children fathered	0.3	0.4	0.9	-0.6	-0.8	-0.9
Medication: Ibuprofen	0.3	0.3	1.2	-0.1	0.6	1.1
Medication: Allopurinol	0.3	0.4	2.0	-1.4	0.2	-0.4
Medication: Aspirin	0.3	0.4	1.6	0.7	0.0	1.3
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.0	-0.3	-0.7	-1.0
Mineral and other dietary supplements	0.3	0.4	1.3	0.2	0.9	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.7	0.7	1.0	1.3
Risk taking	0.3	0.5	0.9	0.8	-0.9	-0.9
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.5	-1.2	0.6	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.7	1.3	-0.4	0.2
Supplements: Calcium	0.3	0.3	1.6	-1.3	0.3	0.1
Depressed Affect (Nagel 2018)	0.2	0.5	1.2	0.6	1.1	1.0
Irritable Bowel Disease (IBD)	0.2	0.4	1.1	-0.8	-1.1	0.2
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	0.7	0.7	0.6
Blood Platelet Count	0.2	2.0	4.9	2.2	-2.1	-0.8
Smoking Status	0.2	0.5	1.5	1.2	0.9	0.5
Cardiovascular Disease	0.2	0.7	3.6	1.9	-0.4	0.2
Impedance of leg (right)	0.2	0.9	4.1	0.1	-2.0	0.4
Fed-up feelings	0.2	0.4	1.0	0.1	0.9	1.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.7	-0.2	0.7	0.8
Sitting height	0.2	1.7	6.0	2.5	-1.5	-0.5
Body mass index (BMI)	0.2	0.8	3.5	1.9	0.5	0.7
Impedance of leg (left)	0.2	0.8	2.1	0.9	-1.4	1.1
Number of incorrect matches in round	0.2	0.4	1.2	1.1	0.0	0.8
Past tobacco smoking	0.2	0.4	1.4	0.1	-1.2	-0.7
Hearing difficulty/problems with background noise	0.2	0.3	1.3	-1.1	-0.1	0.2
Qualifications: None of the above	0.2	0.4	1.1	-1.1	-0.7	0.6
Mouth/teeth dental problems	0.2	0.3	0.8	0.7	-0.9	0.5
Impedance of arm (right)	0.2	0.9	3.4	0.9	-0.1	1.9
Depression (self-reported)	0.2	0.2	0.6	-0.8	-0.3	0.6
Impedance of arm (left)	0.2	0.8	3.7	0.4	-0.1	1.9
Medication: Paracetamol	0.2	0.4	1.7	0.2	-1.3	-0.4
Glaucoma (self-reported)	0.2	0.3	1.4	-0.1	-1.2	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.8	-0.9	-0.5	-0.3
Health satisfaction	0.2	0.2	0.9	-0.4	-0.9	0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.8	-0.5	0.9	-0.2
Medication: Omeprazole	0.2	0.2	0.6	0.8	-0.5	0.4
Overall health rating	0.2	0.5	1.5	-0.4	-0.8	1.2
Age at last live birth	0.2	0.3	1.4	1.2	-0.5	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.9	0.8	-0.9	-0.9
Leg fat-free mass (right)	0.2	1.1	2.3	1.5	-1.5	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.7	0.8	-0.5	0.2
Breast cancer (self-reported)	0.2	0.2	0.6	-0.7	0.8	0.1
Illnesses of father: None of the above (group 1)	0.2	0.3	1.2	-0.2	0.1	-1.1
Leg predicted mass (right)	0.2	1.1	2.3	1.5	-1.5	-0.9
Number of self-reported non-cancer illnesses	0.2	0.3	0.9	-0.9	-0.7	0.5
Wears glasses or contact lenses	0.2	0.3	0.7	0.8	0.1	0.8
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.7	-0.8	0.6	0.5
Eye problems/disorders: Glaucoma	0.2	0.2	0.7	-0.1	-0.8	0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.6	-0.7	0.3	-0.8
Alcohol drinker status: Never	0.2	0.3	0.8	-0.6	0.9	0.5
Fractured/broken bones in last 5 years	0.2	0.3	0.8	0.6	-0.9	-0.4
Unable to work because of sickness or disability	0.2	0.3	1.0	-1.0	-0.1	-0.7
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	0.4	-0.4	0.2
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.0	0.4	0.5
Reaction Time	0.1	0.2	0.8	0.9	-0.2	-0.6
HbA1C	0.1	0.1	0.4	-0.6	-0.2	-0.4
LDL Cholesterol	0.1	0.2	0.4	-0.7	0.4	0.6
Ulcerative Colitis	0.1	0.1	0.7	-0.2	0.1	0.8
Blood Eosinophil Count	0.1	0.8	2.3	1.5	0.5	1.1
Systolic Blood Pressure	0.1	0.3	0.9	0.6	0.1	-0.9
Tanning	0.1	0.7	3.1	1.8	-0.1	0.7
Relative age of first facial hair	0.1	0.2	0.8	-0.0	-0.5	-0.9
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.6	0.2	-0.8	0.0
Systolic blood pressure, automated reading	0.1	0.3	1.2	0.6	0.1	-1.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.2	-0.1	-0.6
Medication for hormone replacement therapy	0.1	0.1	0.4	0.6	-0.4	0.1
Severe depression (siblings)	0.1	0.1	0.4	0.3	0.6	0.1
Hand grip strength (right)	0.1	0.1	0.5	0.4	0.2	0.7
Maternal smoking around birth	0.1	0.2	0.8	0.3	-0.9	-0.2
Age when periods started (menarche)	0.1	0.1	0.6	0.0	0.2	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.5	0.4	0.7	0.1
High blood pressure	0.1	0.3	0.7	0.8	-0.9	0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	-0.7	0.2	-0.4
Chronic bronchitis/emphysema (father)	0.1	0.1	0.4	0.1	-0.7	-0.2
Pain all over the body in last month	0.1	0.1	0.2	0.3	0.5	0.5
Medication: Ramipril	0.1	0.1	0.3	-0.5	-0.3	0.1
Hip circumference	0.1	0.6	1.8	1.4	-1.0	-0.2
Worrier / anxious feelings	0.1	0.2	0.4	-0.6	0.5	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	1.0	-1.0	-0.0	0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.9	0.9	-0.6	-0.4
Pulse rate	0.1	0.2	0.6	0.7	-0.6	0.3
Noisy workplace	0.1	0.2	0.5	-0.5	0.2	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.7	-0.2	-0.3	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.4	0.6	-0.6	-0.6
Exposure to tobacco smoke at home	0.1	0.2	0.4	-0.6	0.2	-0.6
Breastfed as a baby	0.1	0.2	0.8	0.1	0.9	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.8	0.1	0.3	0.9
High blood pressure (siblings)	0.1	0.1	0.3	0.5	-0.4	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.6	0.1	-0.0	-0.8
Age at first live birth	0.1	0.1	0.4	-0.1	-0.5	-0.6
Medication for pain relief, constipation, heartburn	0.1	0.1	0.4	-0.7	0.2	-0.3
Mean time to correctly identify matches	0.1	0.2	0.7	0.8	0.5	-0.0
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.5	-0.7	-0.5	-0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	-0.5	0.4	-0.6
Hypertension (Self-reported)	0.1	0.3	0.9	0.9	-0.5	0.5
Illnesses of father: Heart disease	0.1	0.1	0.6	-0.2	-0.8	0.0
Ever had bowel cancer screening	0.1	0.1	0.3	-0.2	-0.4	-0.6
Commuting to job workplace: Walk	0.1	0.1	0.4	0.6	-0.0	-0.5
Guilty feelings	0.1	0.1	0.3	-0.6	-0.2	-0.1
Medication: Paracetamol	0.1	0.1	0.3	0.0	-0.5	-0.5
Age started oral contraceptive pill	0.1	0.1	0.2	-0.4	0.4	-0.5
Commuting to job workplace: Cycle	0.1	0.1	0.4	0.5	0.6	0.1
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.8	-0.9	0.5	-0.8
Heart disease (siblings)	0.1	0.1	0.4	-0.7	-0.5	-0.0
Impedance of whole body	0.1	0.7	2.6	0.3	-0.9	1.6
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.3	-0.3	-0.6	-0.1
Hand grip strength (left)	0.0	0.0	0.1	-0.1	-0.3	0.3
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.2	-0.1	-0.4	-0.0
Angina	0.0	0.1	0.2	-0.4	-0.2	0.2
Medication: Metformin	0.0	0.0	0.1	-0.3	0.4	0.1
Relative age voice broke	0.0	0.0	0.1	-0.1	0.0	-0.3
Had menopause	0.0	0.0	0.0	0.1	0.0	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.3	-0.4	0.5	0.1
Diabetes (self-reported)	0.0	0.0	0.1	0.3	-0.1	0.1
Length of working week for main job	0.0	0.0	0.1	0.4	-0.2	0.1
Loud music exposure frequency	0.0	0.0	0.1	-0.1	-0.3	0.0
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.2	0.2	0.3	-0.4
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.0	0.1	-0.1	-0.1
Exposure to tobacco smoke outside home	0.0	0.1	0.2	-0.4	0.3	0.1
Angina (self-reported)	0.0	0.1	0.2	-0.5	-0.1	0.3
Pulse rate, automated reading	0.0	0.1	0.2	-0.4	-0.4	0.2
Long-standing illness, disability or infirmity	0.0	0.1	0.1	-0.3	-0.2	-0.4
Diabetes diagnosed by doctor	0.0	0.1	0.3	0.2	-0.1	0.6
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.2	0.2	0.5	0.2
Miserableness	0.0	0.1	0.2	-0.3	0.4	0.3
Medication: Atorvastatin	0.0	0.0	0.1	0.0	-0.3	0.2

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