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chr16:68,523,336-71,093,625

Best TWAS P=4.73e-16 · Best GWAS P=2.16e-25 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	COG4	0.19	0.23	enet	28	0.27	4.3e-33	-4.4	5.8	5.8e-09	-0.25	0.85	0.14	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NOB1	0.04	0.05	enet	12	0.04	7.2e-06	-5.7	6.0	1.9e-09	-0.43	0.93	0.05	FALSE
3	GTEx	Adipose Subcutaneous	NFAT5	0.09	0.02	enet	19	0.05	8.2e-05	-2.2	-7.0	3.3e-12	0.38	0.12	0.44	TRUE
4	GTEx	Adipose Subcutaneous	COG4	0.29	0.06	lasso	5	0.05	2.9e-05	5.4	5.4	6.7e-08	-0.21	0.01	0.96	FALSE
5	GTEx	Brain Nucleus accumbens basal ganglia	PDXDC2P	0.26	0.17	lasso	5	0.13	2.2e-04	5.6	5.3	1.2e-07	-0.35	0.34	0.04	FALSE
6	GTEx	Breast Mammary Tissue (Female)	PDF	0.07	-0.01	lasso	2	0.00	3.0e-01	3.8	5.3	1.4e-07	-0.31	0.03	0.11	FALSE
7	GTEx	Cells Transformed fibroblasts	COG4	0.23	0.18	lasso	5	0.20	1.3e-14	-4.4	5.8	8.0e-09	-0.24	0.85	0.14	FALSE
8	GTEx	Esophagus Mucosa	COG4	0.14	0.06	lasso	4	0.08	7.8e-06	-4.4	5.6	1.9e-08	-0.22	0.32	0.64	FALSE
9	GTEx	Esophagus Muscularis	TMED6	0.08	0.04	enet	5	0.06	1.2e-04	-4.8	-5.7	1.4e-08	0.11	0.32	0.06	TRUE
10	GTEx	Lung	SNTB2	0.08	0.05	enet	12	0.04	2.8e-04	-2.8	5.1	2.8e-07	-0.25	0.59	0.17	FALSE
11	GTEx	Skin Sun Exposed Lower leg	CYB5B	0.12	0.00	enet	18	0.02	5.4e-03	-1.5	-5.8	7.7e-09	0.48	0.36	0.32	FALSE
12	GTEx	Testis	WWP2	0.30	0.10	lasso	5	0.16	9.2e-08	-5.8	-8.0	1.8e-15	0.68	0.55	0.19	FALSE
13	GTEx	Thyroid	NOB1	0.03	0.01	enet	6	0.02	7.7e-03	-7.5	8.1	4.7e-16	-0.76	0.16	0.50	TRUE
14	GTEx	Thyroid	CTD-2033A16.3	0.03	0.02	enet	7	0.02	6.7e-03	-5.0	7.4	1.1e-13	-0.72	0.17	0.42	FALSE
15	METSIM	Adipose	NOB1	0.03	0.03	lasso	2	0.03	2.8e-05	-5.5	6.8	7.4e-12	-0.57	0.18	0.79	FALSE
16	METSIM	Adipose	WWP2	0.08	0.04	enet	19	0.07	2.7e-10	6.8	7.0	2.3e-12	-0.51	0.68	0.32	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	NFAT5	0.02	0.01	enet	5	0.01	6.6e-04	-4.0	-7.7	1.3e-14	0.76	0.02	0.49	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	NQO1	0.02	0.01	blup	39	0.01	4.3e-03	-5.1	-5.8	6.1e-09	0.73	0.06	0.16	FALSE
19	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CLEC18A	0.10	0.06	lasso	2	0.04	6.3e-03	5.6	5.6	2.6e-08	-0.43	0.04	0.17	FALSE
20	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PDXDC2	0.20	0.02	blup	26	0.07	1.8e-04	5.6	6.1	8.1e-10	-0.35	0.01	0.83	TRUE
21	The Cancer Genome Atlas	Colon Adenocarcinoma	CLEC18A	0.14	0.18	lasso	5	0.15	4.5e-09	5.6	5.8	7.6e-09	-0.45	0.94	0.06	FALSE
22	The Cancer Genome Atlas	Glioblastoma Multiforme	PDXDC2	0.10	0.12	lasso	3	0.10	4.7e-04	5.6	5.6	2.6e-08	-0.43	0.01	0.76	FALSE
23	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	COG4	0.10	0.07	enet	7	0.08	1.9e-09	-4.3	5.7	1.2e-08	-0.20	0.64	0.35	FALSE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PDXDC2	0.14	0.05	enet	6	0.05	3.2e-06	5.6	5.7	9.1e-09	-0.42	0.01	0.98	FALSE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CLEC18C	0.06	0.05	lasso	1	0.04	3.8e-05	5.6	5.6	2.1e-08	-0.36	0.72	0.02	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDXDC2	0.03	0.04	enet	4	0.04	4.0e-05	5.6	5.6	2.5e-08	-0.36	0.02	0.98	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	COG4	0.08	0.08	lasso	3	0.09	1.0e-10	-3.7	5.3	1.2e-07	-0.17	0.79	0.20	FALSE
28	The Cancer Genome Atlas	Lung Adenocarcinoma	COG4	0.03	0.00	blup	30	0.01	9.7e-03	-4.3	5.5	3.7e-08	-0.19	0.07	0.20	TRUE
29	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CLEC18A	0.06	0.10	lasso	1	0.09	6.9e-11	5.6	5.6	2.6e-08	-0.42	1.00	0.00	FALSE
30	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PDXDC2	0.09	0.01	blup	26	0.06	4.7e-05	5.6	5.5	4.8e-08	-0.48	0.01	0.90	TRUE
31	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	COG4	0.11	0.04	lasso	3	0.06	2.3e-03	-4.4	5.6	2.4e-08	-0.23	0.22	0.36	FALSE
32	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PDXDC2	0.26	0.19	lasso	3	0.23	1.3e-09	5.5	5.2	1.6e-07	-0.37	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Rectum Adenocarcinoma	CLEC18A	0.15	0.03	blup	23	0.09	4.3e-03	5.5	6.3	2.4e-10	-0.57	0.01	0.22	FALSE
34	The Cancer Genome Atlas	Soft Tissue Sarcoma	CLEC18A	0.12	0.11	lasso	2	0.11	3.4e-07	5.6	5.6	2.1e-08	-0.46	0.94	0.03	FALSE
35	The Cancer Genome Atlas	Soft Tissue Sarcoma	PDXDC2	0.05	0.01	blup	26	0.03	9.5e-03	5.5	6.3	2.6e-10	-0.40	0.01	0.69	TRUE
36	The Cancer Genome Atlas	Skin Cutaneous Melanoma	CLEC18A	0.17	0.09	enet	8	0.11	8.5e-04	5.5	6.6	3.9e-11	-0.52	0.04	0.25	FALSE
37	The Cancer Genome Atlas	Skin Cutaneous Melanoma	COG4	0.26	-0.01	blup	30	0.02	1.1e-01	-3.1	5.3	1.2e-07	-0.27	0.02	0.27	TRUE
38	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CLEC18A	0.20	0.09	lasso	5	0.08	8.8e-04	6.8	6.8	1.3e-11	-0.59	0.05	0.36	TRUE
39	The Cancer Genome Atlas	Thyroid Carcinoma	PDXDC2	0.12	0.16	blup	26	0.15	1.1e-14	5.6	5.3	8.9e-08	-0.42	0.01	0.99	FALSE